Mentalization and psychosis
Citation for published version (APA):
Weijers, J. (2020). Mentalization and psychosis: trying to understand the un-understandable. Ridderprint. https://doi.org/10.26481/dis.20201208jw
Document status and date: Published: 01/01/2020
DOI: 10.26481/dis.20201208jw
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Download date: 02 Oct. 2021
Mentalization and psychosis Trying to understand the “un-understandable”
Jonas Gijs Weijers
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Mentalization and Psychosis: trying to understand the “un-understandable”
ͻͺǦͻͶǦͶͳǦʹͳͷǦͺ
̹ ǡʹͲʹͲǡ Ǥ ǡǤ ǣȁǤǤ
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Mentalization and psychosis Trying to understand the “un-understandable”
ǡ ǡǤǤǤ ǡ ͺ ʹͲʹͲͳͲǤͲͲ ͺͳͻͺ
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Promotores
ǤǤ ǤǦǤǤ Ǥ ǤǤǤ ǤǤǦȋȌ Copromotor ǤǤǤ Beoordelingscommissie
ǤǤǤǤ ǤȋȌ ǤǤǤǤ ǤǤǤǤ Ǥ ǤǤǤȋǡ´Ȍ ǤǤǤǤȋȌ ȋ Ȍǡ ǡ Ǥ
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Table of contents
PART I Theoretical outline 7
ͻ ǣ ʹͷ PART II Childhood abuse and psychosis Ǧ 47 ǣ Ͷͻ ͻ ǣ ͺ PART III Mentalization based treatment for psychotic disorder 107 Ǧ ǣ ͳͲͻ ǣ Ǧ ͳ͵͵ PART IV ǡConclusion Ǧ ǡ Ǥ 157 Addendum ͳͷͻ185 ͳͺ ʹͳʹ ʹͳ ʹͳͺ ʹʹ͵
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PART I:
THEORETICAL
OUTLINE
Part I Part
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Chapter One:
GENERAL INTRODUCTION
1
J.G. Weijers
Chapter Chapter
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Psychosis and non-affective psychotic disorder
Ǧ Mentalization and psychosis: trying to understand the Ǧ“un - ȋunderstandable” ȌǤ – – ǡ Ǥ . ǡ ǡǤǤǡ ǡǤǤ Ǥ term ‘unǦunderstandability’ was first introduced in 1910 by psychiatrist and philosopher Karl Ǧ Ǥ ǡǦ others “rationally or emotionally as arising from the situation of the patient and due to the situation and his emotions” (Fish Ƭ ǡͳͻͺͶȌǤǡ ȋ Ƭ ǡͳͻͺͶȌǦwhat today would be referred to as ‘aberrant experience’ – Ǥ ǡ ǡ Ǥ Ψ Ǧ ǡ Ǥ ǡ ǡ ǡǤ Ǧͷȋ ǡʹͲͳ͵Ȍǡ ǣǡ ǡ ȋ as ‘positive symptoms’), grossly disorganized or abnormal motor behavior, and negative symptoms, Ǥ ǡ ǡ manic or depressive episodes, and the so called ‘nonǦaffective psychotic disorders’ (Ȍǡ Ǧ Ǥ Ǧͷ ǡ ǡ ǡ ǡ ǡ Ǥ Ǥ
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Social functioning and social cognition in NAPD
ǡ ǡ Ǧ ǡǡ Ǥǡ ǡ 1 ȋ ǡ ƬǡʹͲͳͷȌǤ ǡ ȋ ǡ ǡǡǡƬ ǡ2011). Social cognition is the multifaceted domain of “the mental processes ns” (Fett et al., 2011). It entails the capacity to perceive, interpret, and ȋƬǡʹͲͳͶȌǤ Ǥǡ ǡ ȋǡ ƬǦ ǡʹͲͳȌǤ ǡ Ǥ ǡ Ǥ ǡ Ǥ Ǥ ǡ Ǥ Social cognition according to mentalization theory
ǡ Ǥ ǡǡǡǤ to “put ourselves in another situation and feel ourselves into another’s shoes” (Fish Ƭ ǡ ͳͻͺͶȌǤ mentalisation French psychoanalytic term ‘ ’ and the empirical term ‘theory of mind’, which relates to
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ȋƬǡʹͲͳͶȌǤ ǡ of the concept’s theoretical underpinnings,mentalisation while also diminishing its conceptual depth and clinical Ǥ Ǧ ǡ ǡmentalisation Ǥ ǡ used to mean ‘to make mental’ or ‘to sym’ (see Ƭ ǡͳͻͻ). As such, “understandability” also applies to the activity of mentalizing, meaning ‘to understandmentalisation that which has not yet been understood’. ǡ ȋͳͻͻͳȌ ǡ Ǥ Ǧ ǡ –– Ǥ for ǡ ǡ Ǥ ǡ Ǥ ǡ ǡ ǡ Ǥ ǡ responsive, sensitive and slightly exaggerated or ‘marked’ feedback to the infant’s sensoryǦ ǡ‘motherese’ (see chapter 2). Providing feedback that accurately reflects the child’s sensoryǦ ǡ Ǥ ǡ ǡ ǡǤ allows the child to come into contact with another’s view of its inner experiences, which constitutes Ǥ ǡ ǡ ǦȋǦǡǡ ǡƬ ǡʹͲͲ͵ȌǤ ǡ Ǣ Ǧ ǡǤǤ ǡ Ǥ ǡ ȋǤǤǡǡ ƬǡʹͲͲȌǤ
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ǡ ȋ ƬǡʹͲͲǢǤǡʹͲͳ͵ȌǤ Childhood abuse, mentalizing and psychosis
ǡ ǡǡ ǡ 1 Ǥ ǡ inappropriate responses to a child’s affective states, which may communicate that such states are Ǥ Ǥ ǡ“unǦunderstandability” Ǥǡ ǡͶǤͷΨȋǤǡʹͲͳͳȌ ͺͷΨȋǤǡʹͲͳͷǢǤǡʹͲͳ͵Ȍǡ ȋǤǤǡǡƬǡʹͲͲǢ ǡǡǡ ǡƬ ǡʹͲͳ͵ȌǤ ȋǤǡʹͲͳʹȌǤ Ǧ ȋƬǡʹͲͳʹȌǡ ǡ ȋǤǡʹͲͳͲǢ ǤǡʹͲͳͲǡǤǡʹͲͳͳǢǤǡʹͲͳ͵ȌǤ ǡ ǡȋǡǡǡƬǡ ʹͲͳͷǢ ǡǡǡǡȋʹͲͲͷȌǢǡǡǡ Ƭ ǡʹͲͲǢǤǡʹͲͳͷȌ ȋǤǡʹͲͳͷǢ ǤǡʹͲͳ͵ȌǤ ȋǡǡǡƬǡʹͲͲͷǢ ƬǡʹͲͳͶȌǡ Ǥ ǡ Ǥ ǡǤǤ ǡ ȋ ͵ȌǤ expectations of others’ abilities to help coǦǡ
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Ǥ Ǧǡ ȋ ͶȌǤǡ ȋ ͷȌǤ ǡǤ ǡ uncaring caregiver’s mind may be so overwhelmingly painful for a child, that it instills ȋ ͷȌǤ Operationalization of mentalization
Ǥ “ungainly” and “allǦencompassing” (ChoiǦƬ ǡʹͲͲͺȌ Ǥ ȋʹͲͲͻȌ ǣ ǡ ǡ ǡǤǡ ǡ ǡ ǡǡƬ (2012a) introduced a fifth polarity by introducing the term ‘embodied mentalizing’. Ǧ mentalizing. Implicit mentalizing involves reflexive and intuitive ‘snap’ judgments about internal or Ǥ ǡ process of reflection on one’s own and someone else’s mental states (Fonagy ƬǡʹͲͲͻȌǤ ǡ Ǥ ǡ capacity to detect and process signals on an affective basis, i.e. ‘to feel for someone’. ǦǦ Ǣ people are able to reflect on their own or others’ mental states. Here the two must not be seen as discrete polarities but as dynamically interacting domains. Reflecting on one’s own feelings can ǡ Ǥ clearly distinguish between one’s own mental state and those of others. Ȁ Ǥ ǡ Ǥ
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ǡ ȋʹͲͳʹȌ “the ability to experience the body as the seat of emotions’’. Specifically, embodied mentalizing pertains to the degree of certainty that is attributed to one’s cognitive beliefs or one’s sensoryǦ ȋ ʹȌǤ Measurement of mentalization 1 Ǥ Ǧ ǡ understand one’s mentalizing deficits. Furthermore, the field of ǤǦǦ ǡ ȋ ǡʹͲͲͺǢ Ƭ ǡʹͲͳͻȌǤ ǡ Ǥ Ǧ Hinting Task ȋ Ȍ ȋǤǡʹͲͳ͵ȌǤ another’s wishes from indirect speech, i.e. the cognitive, otherǦ ‘theory of mind’. ǡ Ǥ ǡ Ǥ Ǧǡ ǡ Ǥ ǡǡ ȋǤǡʹͲͳ͵ȌǤ Ǣ ȋǤǤǡƬǡʹͲͲͻȌǤ Ǧ ȋǢǡ ͳͻͶ͵ȌǤ Ǥ ȋǤǡʹͲͳ͵Ǣ ǡƬ ʹͲͳͻȌǤǡ Ǧ Ǥ ǦǦ Ǥǡ Ǥ
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ǡ ȋǢǡͳͻͻͳȌǡ Ǥ ǣ ǡ the respondents’ ability to differentiate between their own and another’s point of view; understanding of social causality, representing respondents’ ability to give a logical and Ǧminded explanation for another’s beǢ Ǧǡ Ǣ ǡ Ǥ ǡ ȋʹͲͳʹȌǡ ǡ ȋ Ȍ ȋ ȌǤ ǡ ǡ ȋǡʹͲͲͶȌǡ ȋ ǡ Ƭ ǡʹͲͲͳȌ ȋ ǤǡʹͲͲͳȌ ȋǡʹͲͲͶȌ ǦǤ Mentalization based treatment
ǡ ȋǤǤƬǡʹͲͲʹȌǤ to be known as the ‘dodo effect’ of psychotherapy, in which ‘every therapy wins’. Bateman and Ǧ ǡǤǤ common to all forms of psychotherapeutic approaches. They argued that ‘bonafide’ ǡ Ǥ ǡǡ e the patient’s ability to reflect on and Ǧ ǡǤǤǤ Ǥʹ Ǥ ȋƬ ǡͳͻͻͻǢʹͲͲͳǢʹͲͲͺȌ ǡ
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ǡ ȋǤǡʹͲͳ͵Ȍǡ ȋǤǡʹͲͳ͵Ȍǡ ǦȋƬ ǡʹͲͳʹȌǡ ȋǡ ǡǡǡƬ ǡʹͲͳʹȌǡȋǡ ǡƬ ǡʹͲͳͶǢǡǤǡʹͲͳȌȋ±ǤǡʹͲͳȌǤ ǡ ȋMalda‐Castillo, Browne, & Perez‐AlgortaǡʹͲͳͺȌǤ 1 Ǥ Aims and outline of this thesis
AIM I: To outline how mentalization theory may contribute to understanding and treatment of NAPD. Ǥ ǡ ǡ ǡǡ Ǥǡ Ǥ AIM II: o test several hypotheses which have been proposed to explain the relationship between childhood abuse and the severity of symptoms in adult patients with NAPD.
ǡǡ ǡǣǡ Ǥ ǡ ǡ Ǥ Ǥ Ǥ AIM III: To test whether mentalization based treatment for psychotic disorder (MBTp) is an effective
addition to treatment as usual regarding social dysfunction and impaired mentalizing.
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ǡ Ǧ Ǥ Ǥ ȋ Ȍ ȋ ȌǤ References
ǡǤǡ ǡǤǡǡǤǤǡ ǦǡǤǡǡǤǤǡƬǡǤȋʹͲͳͷȌǤ ǣ Psychological medicine, 45 Ǥ ȋͳ͵ȌǡʹʹǦʹ͵Ǥ ǡǤ ǤǡǡǤǡ±ǡǤǡ ǡǤǡǡ ǤǡƬǡ ǤǤȋʹͲͳͳȌǤ The Journal of nervous Ǥand mental disease 199 ǡ ȋ͵ȌǡͳͷǦͳͳǤDiagnostic and statistical manual of mental disorders ǤȋʹͲͳ͵ȌǤ(DSM-5®) Ǥ Ǥ ǡǤǡǡǤǡ ǡ ǤǤǡ ǡ ǤǡǡǤǤǡƬǡǤȋʹͲͳͳȌǤ ̵American ǣ Journal of Psychiatry 168 Ǥ ǡ ȋͳȌǡͷǦʹǤ ǡǤǡƬ ǡǤȋͳͻͻͻȌǤ American journal of Psychiatry,ǣ 156 Ǥ ȋͳͲȌǡͳͷ͵ǦͳͷͻǤ ǡǤǡƬ ǡǤȋʹͲͲͳȌǤAmerican ǣͳͺJournal of psychiatry, 158 ǦǦǤ ȋͳȌǡ͵MentalizingǦͶʹǤ and borderline personality disorder. Handbook of ǡǤǡƬ ǡǤȋʹͲͲȌǤmentalization based treatment ǡͳͺͷǦʹͲͲǤ ǡǤǡƬ ǡǤȋʹͲͲͺȌǤͺǦǦAmerican Journal of ǣPsychiatry, 165 ǦǤ ȋͷȌǡ͵ͳǦ͵ͺǤ ǡǤǡǡǤǡƬ ǡǤȋʹͲͳ͵ȌǤ ǣFocus, 11 Ǥ ȋʹȌǡͳͺǦͳͺǤ ǡǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡǡ ǤǤǡǤǤǤƬǡǤ (2010).Acta Experience Psychiatrica of trauma Scandinavica and conversion121 to psychosis in an ultra‐high‐risk (prodromal) Ǥ ǡ ȋͷȌǡ͵Ǧ͵ͺͶǤ
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ǡǤǡ ǡǤǡƬǡǤȋʹͲͲͺȌǤ ǣBehaviour research Ǥand therapy 46 ǡ ȋͳʹȌǡͳʹͷǦͳʹͺʹǤ ǡǤǤǡ ǡǤ ǤǡƬǡǤǤȋʹͲͳͶȌǤǦ ǣ Ǧ The Israel journal of psychiatry and Ǥrelated sciences, 51 1 ȋͳȌǡͳǤ ǦǡǤǤǡƬ ǡ Ǥ ǤȋʹͲͲͺȌǤǣǡǡ . American Journal of Psychiatry, 165 ȋͻȌǡ ͳͳʹǦͳͳ͵ͷǤ ǡǤǤǡǡǤǤǡǡ ǤǤǡǡǤǤǡǡǤǤǡƬǡ ǤȋʹͲͳͲȌǤ Child abuse Ͷ͵Ǥ & neglect 34 ǡ ȋͳͳȌǡͺͳ͵ǦͺʹʹǤ ±ǡǤǡǡ Ǥǡǡ ǤǡǦǡǤǡǡǤǡ ǡǤǡƬǡǤ ȋʹͲͳȌǤJournalǦ of Contemporary PsychotherapyǦ ǣ46 Ǥ ǡ ȋͶȌǡʹͳǦʹʹͷǤ ǡ ǤǡƬǡǤ ǤȋʹͲͳͷȌǤ Journal of Clinical Psychology 71 Ǥ ǡ ȋʹȌǡͳͳǦ ͳʹͶǤ ǡǤǡǡǤǡǡǤǡ ǡǤǡǡǤǡǡ ǤǡǤǤǤƬ ǡ ǤȋʹͲͳͷȌǤ Australian & New Zealand Journal of Psychiatry, Ǥ 49 ȋȌǡͷͳǦͷͻǤ ǡǤǤ Ǥǡ ǡǤǡǡǤǤǡǡ ǤǡƬǡǤȋʹͲͳͳȌǤ ǣNeuroscience & Biobehavioral Reviews 35 ǦǤ Fish's schizophrenia. ǡ ȋ͵Ȍǡͷ͵ǦͷͺͺǤ ǡ Ǥ ǤǡƬ ǡǤȋͳͻͺͶȌǤ ǡǡǤ ǡǤȋͳͻͻͳȌǤǣ International Journal of Psycho-Analysis, 72, Ǥ ͵ͻǦͷǤ ǡǤǡƬǡǤȋʹͲͲͻȌǤǡǦ Development and psychopathology,Ǥ 21 ȋͶȌǡͳ͵ͷͷǦͳ͵ͺͳǤ Comprehensive ǡǤǡƬǡǤǤȋʹͲͳȌǤǡ ǡǤpsychiatry 64 ǡ ǡͷͻǦǤ
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ǡǤ ǤǡǡǤǤǡǡǤǡǡǤǤǡ ǡǤǡ ǡǤǤǡǤǤǤƬ ǡǤȋʹͲͲͺȌǤ ǣ ǡǡSchizophrenia bulletin, 34 Ǥ ȋȌǡͳʹͳͳǦͳʹʹͲǤ Nature Reviews ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͷȌǤ ǤNeuroscience, 16 ȋͳͲȌǡʹͲǤ ǡǤǡ ǡǤǡƬ ǡ ǤȋʹͲͲͳȌǤ Journal of Personality Assessment, 77 Ǥ ȋ͵Ȍǡ ͶͲͺ–ͶͳͻǤ ǡǤǤǡƬ ǡǤ ǤȋʹͲͳͻȌǤ ǣSchizophrenia research, 203 Ǥ ǡ͵ǦͳͳǤ ǡǤǤǡƬǡǤǤȋʹͲͳͶȌǤ ǣ The Lancet 383 ǦǦ Ǥ ǡ ȋͻͻʹͻȌǡͳǦͳͺǤ ǡ Ǥǡǡ Ǥǡ ǡǤǡǡ ǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͳ͵ȌǤ ǣ ǡ ǡAmerican Journal of Psychiatry 170 Ǥ ǡ ȋȌǡ͵ͶǦͶͳǤ ǡǤǡǡǤǤǡǡǤǡÞǡ Ǥ ǤǡǡǤǡǡǤǤǡǤǤǤƬǡ ǤȋʹͲͳ͵ȌǤ Comprehensive Psychiatry 54 Ǥ ǡ ȋʹȌǡͳʹ͵ǦͳʹǤ ǡ Ǥǡ ǡǤǡ ǡǤǡǦǡ ǤȋʹͲͳȌǤ ǣ ǤSchizophrenia treatment. Ǥ ǡǤǡƬ ǡǤǤȋͳͻͻȌǤǣ International Journal of Psycho-Analysis, 78 Ǥ ǡͺͷͷǦͺͷǤ ǡǤǡǡǤǡƬǡ ǤȋʹͲͳȌǤ ǣEpidemiology and psychiatric sciences, 25 ǫ ȋͶȌǡ͵ͶͻǦ͵ͷͻǤ ǡǤǡ ǡǤǡǡǤǡǡǤǡƬ ǡǤȋʹͲͳʹȌǤǦ ǤPsychoanalytic Psychotherapy, 26 ȋʹȌǡͳʹͳǦͳͶͲǤ Ǥǡ Ǥǡ ǤǡǤȋʹͲͳʹȌǤHandbook of mentalizing in mentalǤ Ƭ health practice, ȋʹͲͳʹȌǤ Ͷ͵–ͷǤǡǣ Ǥ
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ǦǡǤǡǡǤǡ ǡǤǡƬǡ ǤȋʹͲͲ͵ȌǤ Attachment & Human Development, Ǧ Ǥ ͷȋͶȌǡ͵͵ͲǦ͵ͷʹǤ ǡ ǤǤǡǡǤǡǡǤǡ ǡǤǡƬǡǤ ǤȋʹͲͳ͵ȌǤ ǣ Child Abuse & Neglect, 37 Ǥ ȋͳȌǡͳͶǦʹͳǤ 1 Malda‐Castillo, J., Browne, C., & Perez‐Algorta, G. (2018). Mentalization‐basedPsychology and Psychotherapy: treatment and Theory, its evidence‐baseResearch and Practice status: A systematic literature review. Ǥ ǡǤǤǡƬǡǤǤȋʹͲͲʹȌǤ̵ ǣ Clinical psychology: Science and practice, 9 Ǥ ȋͳȌǡʹͳǦʹͷǤ ǡ Ǥ ǤȋʹͲͲͶȌǤ ȋȌ Comprehensive handbook ǣ of psychological assessment, 2, Ǥ ͵ͳͷǦ͵ͶʹǤ Thematic Apperception Test, ǡ ǤǤȋͳͻͶ͵ȌǤ ǡǡǤ ǡǤǡǡǤǤǡ ǡǤǡ ǡǤǡǡǤǤǡƬǡǤǤȋʹͲͳ͵ȌǤ Frontiers in Human Neuroscience 7 Ǧ Ǥ ǡ ǡͺͳǤ ǡǤǤǡǡǤǤǡ ǡǤ Ǥǡ ǡǤǡ ǡǤǡƬ ǡǤǤȋʹͲͳ͵ȌǤ ǣǤSchizophrenia bulletin, 40 ȋͶȌǡͺͳ͵Ǧͺʹ͵Ǥ ǡ Ǥǡǡ ǤǡǡǤǤǡƬǡǤǤȋʹͲͲͷȌǤǡ Acta ǣPsychiatrica Scandinavica, Ǥ 112 ȋͷȌǡ͵͵ͲǦ͵ͷͲǤ ǡǤǤǡƬǡǤǤȋʹͲͲͻȌǤ ȋ ȌPsychiatry research, 166 ǣǤ ȋʹǦ͵ȌǡͳͶͳǦͳͶǤ ǡǤǡ ǡ ǤǡǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͳȌǤ Ǧ ȋǦȌ ȋTrials,ǦȌ Ǥ17 ȋͳȌǡͷͶͻǤ
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ǡǤ ǤǡƬ ǡǤȋʹͲͳʹȌǤJournal of theǦ American Academy of ChildǦ & Adolescent ǣ Psychiatry, 51 Ǥ ȋͳʹȌǡͳ͵ͲͶǦͳ͵ͳ͵Ǥ ǡǤǤǡǡǤǤǡǡǤǡƬǡǤǤȋʹͲͲͷȌǤ ǣSchizophrenia ǡǡ research, 76 Ǥ ȋʹǦ͵Ȍǡʹ͵ǦʹͺǤ ǡ ǤǡǡǤǡǡǤǡ ǡ ǤǤǡƬǡ ǤȋʹͲͲȌǤ The British Journal of Psychiatry, 188 ǣ Ǥ ȋȌǡͷʹǦͷ͵͵Ǥ ǡǤǤǡǡ ǤǡǡǤǡƬǡǤȋʹͲͲȌǤǦ ǣChild abuse & neglect 31 Ǧ Ǥ ǡ ȋͷȌǡͷͳǦͷ͵ͲǤ ǡ Ǥ ǤǡÞ ǡǤǡ ǡǤǤǡ ǡ Ǥǡ ǡ ǤǤǡǡ ǤǡǤǤǤƬǡǤǤ ȋʹͲͳ͵ȌǤ Schizophrenia bulletin, 40 Ǧ Ǥ ȋȌǡͳͶͻͳǦͳͶͻͺǤ ǡǤǡƬǡǤǤȋʹͲͳʹȌǤ Schizophrenia bulletin, 38 Ǥ ȋͶȌǡʹǦͷǤ ǡǤǤǡǡǤǡ ǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬ Ǧ ǡ ǤȋʹͲͳͷȌǤ Psychological Medicine, 45 Ǥ ȋȌǡ ͳ͵͵Ǧͳ͵Ǥ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳʹȌǤ ǣSchizophreniaǦ bulletin 38 Ǧ ǡ Ǧ Ǧ Ǥ ǡ ȋͶȌǡͳǦ ͳǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬǡ ǤǤȋʹͲͳȌǤBMC psychiatry,Ǧ ǣ 16 Ǥ ȋͳȌǡͳͻͳǤ . Journal of personality ǡǤȋͳͻͻͳȌǤ assessment, 56 ȋͳȌǡͷǦͶǤ
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Chapter Two:
ǣ JournalMENTALIZATION of Contemporary Psychotherapy (2020) AND Ǧ J. G. Weijers1,2*, C. ten Kate1,2, M. Debbané, A.W. Bateman, S. de Jong, J.-P.C.J Selten1,2, E.H.M. Eurelings- BontekoePSYCHOSIS: A RATIONALE
FOR THE USE OF MENTALIZATION THEORY TO UNDERSTAND AND TREAT NON-AFFECTIVE PSYCHOTIC DISORDER 2
1
ǡǤ ʹ ǡ ǡǤ ͵ ± ̵2 ǡ± °ǡ Ͷ J. ǡǡ G. Weijers, C. ten Kate, M. Debbané, A.W. Bateman, ͷ ǡ ǡǡǡ S. de Jong,ȗ J.-P.C.J Selten, E.H.M. Eurelings-Bontekoe Ǥ ǣ ǡǤ̷ǤǤ
Journal of Contemporary Psychotherapy (2020) Chapter Chapter
146807_JonasWeijers_BNW_def.indd 25 28-10-2020 15:08 Chapter Two
Abstract
Ǧ ȋȌǤ Ǥ ǡ Ǥ Ǥ ǡ ǡ Ǥ Ǥ ǡ Ǥ Keywords: ǡ ǡ ǡǡ ǡ Part I: A mentalization based model of psychosis pathogenesis
Introduction.
ǡ ȋ ƬǡʹͲͳͶȌ ǡ ǡǡ ǡ ––ǡ ȋǤǤǡǦ ȌǤ ȋǤǤǡȌ Ǥǡ Ǥ ǡ ȋƬÞǡʹͲͲͺȌǤǡ Ǧ ȋǤǤǡǡǡǡƬǦ ǡʹͲͳ͵ȌǤ ǡ ȋ ƬǡʹͲͳͶȌ ǡ ǡ psychotic or “positive” symptoms, such as delusions or hallucinations. However, nonǦ
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ͳ ȋ Ȍ ǡ ǡ ȋ ǡ ƬǡʹͲͳͻȌǡ Ǥ ǡ Social dysfunction and social cognition in NAPD. Ǥ ȋǤǤǤǡ ʹͲͲͻǢǤǡʹͲͳͲǢǤǡʹͲͳͷȌǤ 2 ǡ ȋǡǡƬ ǡʹͲͲ͵Ȍǡ isȋǤǤǡ ǤǡʹͲͳ͵ȌǤ ǡ ǡ ͳͶΨͷ͵ΨȋǤsocial ǡʹͲͳȌǤ ǡ ȋǡǡƬǡʹͲͳʹǢ ƬǡʹͲͲͻȌ ȋǡǡ Ƭ ǡʹͲͳ͵Ǣ ǡǡǡƬǡʹͲͳȌ Ǥǡ ǡ ȋǤǤǡ ǤǡʹͲͲȌǤ Ǥ ȋ ǡ ǡǡƬǡʹͲͳͳȌǡ Ǥ specific aspects of social cognition such as facial affect recognition or “theory of mind,” i.e., the ȋ ǤǡʹͲͳͻȌǤ ǡ Ǧ Ǥ that ǡ why ǡ Ǥ lines of research have therefore taken a more ‘holistic’ approach, proposing that underlying social ȋǤǡʹͲͲ͵Ȍ ȋ ǡͳͻͺͻȌ ȋǤǡʹͲͲͷȌǤ
ͳ Ǧ ȋȌǡ Ǥ
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ǡ ǡ ǤSocial cognition, mentalization and metacognition. ǡ Ǥ ǡ ȋƬ ǡʹͲͲȌǤ others through the simulation of others’ experiences, through mirror neurons and shared sensoryǦ ȋ ǡʹͲͲͷȌǤ implicitly, through shared feeling. ‘Theory’ on the other hand, holds that we come to understand others through the cognitive inference of “rules” from observed social situations, thus ȋǤǤǦǡƬ ǡͳͻͺȌǤ Ǥ ǡ Ǥ—defined as a form of “imaginative mental activity through which behavior is interpreted in terms of mental states like needs, feelings, beliefs and goals” (Bateman & ǡʹͲͲͶȌ— ǡǡ Ǧ ǡ ǡ Ǧ Ǥ “spectrum of mental activities by which persons form integrated ideas about their own minds and those of others” (LysakerƬʹͲͳͶȌǤ Ǥ e do not just experience another’s mental state — ȋ ǡʹͲͲͷȌ— Ǧ Ǥ ǡ ǡ ǡǡ parent’s capacity to reflect on the mind of Ǥ ǡ ͳ Mentalizing impairments and NAPD. Ǥ Ǥ ȋ
ͳ ǡ ǡǤȋʹͲͳȌǤ
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ǡƬ ǡʹͲͲͷǢǡ ǡǡ ǡƬǡʹͲͲȌ stand others’ emotional expressions (O’Driscoll, Laing & Mason, 2014). They also tend to have Ǧ ȋǤǡʹͲͲȌ ȋ±ǡʹͲͲȌǤ ȋͳͻͻʹȌ Ǥ ǡ ǡ ǡ Ǥǡ ǡǡ ǡ 2 ȋ ǡͳͻͻʹȌǤ ǡ Ǥ Ǥ ǡ ȋǤǤ Ǧǡ ǡǦǡ ǡǡʹͲͳͺǢ ǡ ǡ ǡ ƬǡʹͲͳͶȌ ȋ ǤǡImpaired embodiedʹͲͳͶǢǤǡʹͲͳͺȌǤ mentalizing in NAPD. ±ǤȋʹͲͳȌ Frith’s hypothesis by suggesting that patients with NAPD suffer specifically from problems with ‘embodied’ mentalizing. Embodied mentalizing Ǧaffective signals coming from one’s body and to critically think about them. Indeed, Ǧǡ ‘sourcemonitoring errors’ (see Brookwell, Bentall & Varese, 2013 for an overview). Problems in detecting and accurately representing one’s own sensoryǦ ȋƬǡʹͲͲͻǢǡ ǡǡƬ ǡ ʹͲͳͶȌǤ ǡ one’s sensoryǦ Ǥ ǡ Ǥ ǡ EpistemicǦ Ǥ mistrust and cognitive biases in NAPD. Ǧ to others’ viewpoints. Psychosis ofte (‘common’ sense in its literal meaning) and ‘epistemic trust’ (e.g. Pereira & Debbané, 2018).
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Epistemic trust is defined as the “willingness to consider new knowledge from another person as ǡgeneralizable, and relevant to the self” (Fonagy et al., 2015). According to the ǡ ǣ ǡ Ǧȋ ǡǡƬǡʹͲͳȌǤ ǡ ǡ Ǥ ǡ Ǥǡ ǡ similar ways. Customs and values often have opaque functions but are nonetheless important to “ in”. Contributors to impaired mentalizing and psychosis. ǡ Ǥ ǡ Ǥ ȋǤǡʹͲͳʹǢǡ ǡǡƬǡʹͲͳͶ ȌǤǦ ͺΨȋǤǡʹͲͳͷȌǡ ȋǤǤǤǡʹͲͳ͵ȌǤ ȋ ǤǡʹͲͳ Ȍ ȋǤǡʹͲͳͺȌǤ ǡ ȋǤǤǡǡʹͲͳͷȌǤ Such relationships are characterized by a genuine interest in the child’s mental state that is through ostensive cues (e.g., eye contact) and ‘marked mirroring,’ wherein emotions are imitated in a slightly exaggerated fashion, sometimes referred to as ‘motherese’ (Kim, 2015). In this way, a child has his emotions “reǦpresented” back to him, which p ȋ ƬǡʹͲͳͶȌǡ ǦǤ
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ǡ ǡ Ǧreflectivity is fostered by ‘intersubjectivity’, a communicative process ȋǤǡ ʹͲͲͷȌǤ of mentalizing in children (Kim, 2015) “to protect themselves from acknowledging their caregiver’s wishes to harm them” (Fonagy, 1989). Inhibiting me ͳ Ǥ 2 Ǥ Ǥ ǡ ȋǡͳͻͺͲȌǤ ǡ ǡ Ǥ ǡ ǡ Ǥ Ǧregulated called ‘attachment styles’ (e.g., Berry, ƬǡʹͲͲͺȌǤ ǡ ǤͲΨͺͻΨȋ Ȍ ȋǤǤǡ ǡǡ Ƭ ǡʹͲͳͶȌǤ ʹͲΨʹͷΨ ȋǡǡƬǡͳͻͺǢ ǡƬǡͳͻͻȌͳʹΨͳͷΨ ȋǤǤǡ ƬͳͻͻͲȌǤǡ ȋǡ ƬǡʹͲͳ͵ȌǤ ȋǤǡʹͲͳ͵ȌǤ Here, it is important to note that mentalizing is viewed as a complex ‘higherǦ
ͳ ǡ to the days of the “schizophrenogenic” mother ȋ ǡͳͻͻȌǤ ȋǡƬǡʹͲͲǢǡʹͲͲͷȌ ȋ ƬʹͲͳʹȌǤǡ – ȋǡ ǡƬǦ ǡʹͲͳ͵ȌǤ ȋ ǤǡʹͲͳȌǤ
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process’ in which functions of the prefrontal cortex, such as working memory and the direction of ǡ ǡǡ ͳ ȋ ƬǡʹͲͳȌǤ When overly stressed, the orchestration of the brain’s ǡ ǡ ǡȋǡʹͲͲͻȌ ǤInsecure attachment and epistemic mistrust. ȋʹͲͳͶȌ ǡ ǡ Ǥ When a child finds himself accurately represented by a caregiver “as a thinking and feeling intentional being”, this is thought to engender the secure feeling that the caregiver’s in ǡ Ǥ ǡ ȋƬ ǡʹͲͳͷȌǤ ǡ ǡ develop a chronic mistrust regarding others’ messages. Indeed, both insecure attachment styles and ǦȋƬ ǡʹͲͲ͵Ȍ ȋǤǤǡ ǡͳͻͻȌǤͳ Ǥ
ͳ Similarly, synthetic metacognition is thought to be the process combining “atoms of experience” into larger, ȋ ǦǤǡʹͲͳͺȌǤ
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2
Fig.1 A heuristic, mentalization based model of psychosis pathogenesis.
ǡ ǡ Ǥ ǦǤ ǡǡ Ǥ Ǥ ǡ Ǥ Ǧ ǡ ǤǡǦ ǡǤ
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Part II: Implementation of mentalization based treatment for NAPD
ǡ ȋ ƬǡʹͲͳͶȌǤ ǡ ǡ ǤPrinciples of Mentalization Based Treatment. ȋȌ ȋƬ ǡͳͻͻͻȌ mistrust (Fonagy & Allison, 2014), through four main principles: a ‘notǦknowing’ therapeutic ǡǡ ǡ patient’sǤ Firstly, MBT emphasizes that therapists adopt a ‘notǦknowing stance,’ which entails that the therapist actively questions the patient and cultivates a genuine interest in the patient’s current Ǥ ǡ therapist communicates that she is trying to interpret the patient’s actions in line with her own ȋ±Ǥǡ 2016; Fonagy et al., 2017). Feeling “mentalized about” in therapy is thought to make the patient feel ȋ ƬǡʹͲͳͶȌǡ tructuring of the “organization of thinking into less rigid, delusional and pervasive patterns of reality testing” (Pereira & Debbané, 2018). Becoming more flexible in one’s cognitive beliefs, opens up the opportunity to again learn from experience and er perspectives, which is thought to lead to an improvement of understanding one’s self and the Ǥ ǡ Ǧ Ǥ ȋʹͲͲȌ ǡ “psychotherapists of many orientations often attempt to provide mentalistic understandings for inaccessible.” Therefore, MBT deǦemphasizes the exploration of ‘deep’ ǡ ǡ Ǥ ǡ and therapist should be on the patient’s current affective Ǥ ǡ Ǧ ȋƬ±ǡʹͲͳͺȌǦ
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ǡ ǡ ȋǤǤǡƬ ǡʹͲͳͺȌǤ ǡǡǡ ǡ Ǥ ǡ Ǥ ǡ much arousal will reduce a patient’s ability to mentalize. At this level only supportive interventions ǤMentalization based treatment in contrast to other psychotherapies. 2 ǤǡȋȌ ǡ Ǥ ǡ Ǥ ȋǤǤÚƬ ǡʹͲͲȌǤ ǡ ǡ ǡ Ǥ ǡ ǡ ǡ Ǧ Ǥǡ ǡ relationship than CBT. Lastly, CBT takes a less ‘holistic’ approach to treatmenǡ Ǥ More akin to MBT, are the so called ‘third wave’ cognitive behavioral therapies. Whereas ǡ ǡǡ ȋǡ Ƭwhat how ǦǡʹͲͳȌǤ ǡ ȋÚƬ ǡʹͲͲȌǤ Ǧǡ ǡ ȋǤǡʹͲͳ ȌǤ ǡǡ Ǥ ǡ Ǧ Ǥ ȋ Ǣ ǤǡʹͲͳͺȌǤǤȋʹͲͳͻȌ Ǥ ǡǡ
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ǡ ǡǡ Ǥ ǡ rocessing by engaging the patient’s ability to Ǥ ǡ searching for the patient’s narrative rather than ‘the truth’. Lastly, both emphasize that therapeutic tions should be adjusted towards the patient’s level of metacognition. ǡǡ ǤȋʹͲͳͻȌǤ Ǧ Ǧ Ǥ ȋ±ǤǡʹͲͳȌǤ ǡǦ ǡ ǦȋǡʹͲͲͻǢ±ǤǡʹͲͳȌǤ ǡ icitly on the patient’s agency, by explicitly making the ǤǡǦ ǡ ǤMentalization based treatment for psychotic disorder. ȋǢƬ ǡͳͻͻͻȌǡ ǡǤ ȋƬ ǡʹͲͳͶǢǤǡʹͲͳǢ±ǤǡʹͲͳȌ ȋǤǡ ʹͲͳȌǤ ǡǦ Ǥ ǡ Ǧ Ǧ Ǥ Ǥ ǡ ǡ Ǥ ǡ Ǥ ǡ ǡ ǡ
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Ǥ ǡ nd it relatively easy to drop out of treatment. Keeping patients ‘in mind’ through ǡǤ Third, we concur with Gumley and Liotti’s (2008) observation that a more severe Ǥ ǡ Ǧ Ǥ 2 Ǥ ǡ Ǥ ǡ Ǥ Clinical Vignette. Ǥ ǡ Ǥ Hi, how are you feeling? ǣ: Yeah, I’m good; I’ve been onȋ holiday with ǤȌ my girlfriend, which was mostly good. Mostly good? ǣ Yeah, we had fun,ȋ but I also had a falling-outǦ Ȍ with her, which is still bothering me. I tried to talk to ǣher about my views on the world. I really wanted her to see my point of view. In what way is this still bothering you?
ǣ I have experiences like this all the time, ȋǡ ǤȌwith friends, for example. I sometimes just feel that if they ǣsaw it my way, they would agree with me. (Here, the patient is focused on the ‘then and there,’ but is ǤȌ How does that make you feel now? ǣ ȋ ǤȌ I have put a lot ǣof researchȋ ǡǤȌ into how the world works. We are being deceived; the evidence is there. ȋ Ǣ ǡ Ǥ Ǥ ǤȌ
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Hey, I see you are getting a bit agitated. This must be difficult for you!
ǣ ȋ ǡ reduce the levelIt’s no of use stress talking by validating about this the stuff, patient’s because feelings.) you people simply adhere to what we have been ǣȋȌfed by the media, like sheep. I get the feeling that you are all against me, but I am used to it. ȋ ǡ Ǥ individuals, lumping everyone in one category, he is now likely unable to consider therapist’s I’m veryǤȌ sorry to hear that you perceive everyone is against you. That must be so difficult to bear, ǣthat perception that everyone is against you. ȋ ǡ ǡ Ǥ like ‘perceive’ and ‘perception’ the therapist also addresses the fact that the patient’s view is ǡ ǤȌ I don’t necessarily think are against me, but many people are. ǣ ȋȌ ȋ ǡǤȌ Hey, it seems to me that you got a little worked up there, but that now you have also calmed down a ǣbit. Could you help me understand what happened there? ȋ ǡ ǤȌ I get worked up about this stuff, and then I get angry with people for no reason. ǣ: Shall we look at what happened there then? It seems like you lumped me together with people you dislike ȋ ǡ ǤȌ I react to people too quickly because I don’t like it when people do not agree with me. I think I get ǣupset, when I have the feeling people do not take me seriously. ȋ ǡ ǡ ǤȌ Concluding Remarks
ǡ ǡ ǤǦ ǡǦ Ǥ
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Acknowledgments
Ǥ Funding
ǡ ǡ ǦǦ Ǥ Compliance with Ethical standards 2 ǤȋǡǤǡʹͲͳȌ ȋͳ͵Ǧ͵ǦͲǤͷȀȌǤ ǡ Ǥ Conflicts of interest
Ǥ References
Patterns of attachment: A
ǡǤǤǤǡǡǤǤǡǡǤǡƬpsychological study of the strange situation.ǡǤǤȋͳͻͺȌǤ Hallucinations: The scienceǡǣ Ǥ of idiosyncratic perception ǡǤǡƬÞǡ ǤȋʹͲͲͺȌǤ Ǥ Ǥ ǡǤ ǤȋʹͲͲͻȌǤNature Reviews Neuroscience 10 Ǥ ǡ ȋȌǡͶͳͲǤ ǡǤǡ ǡǤǡǡǤǡǡǤǤǡ ǡǤǤǡòǡǤǡƬǡPsychiatryǤ ǤȋʹͲͳȌǤ research Ǥ ǡʹͶͷǡ ͳͷǦʹͳǤ ǦǡǤǡǡǤǤǡƬ ǡǤȋͳͻͺȌǤ ǡBritish Journal of Developmental Psychology, 4, Ǥ ͳͳ͵–ͳʹͷǤ
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ǡǤǡƬ ǡǤȋͳͻͻͻȌǤ American Journal of ǣ ǤPsychiatry 156 ǡ ȋͳͲȌǡͳͷ͵ǦͳͷͻǤ Journal of personality ǡǤǤǡƬ ǡǤȋʹͲͲͶȌǤdisorders, 18 ǦǤ ȋͳȌǡ͵ǦͷͳǤ ǡǤǡƬ ǡǤȋʹͲͲȌǤǤ ǡ Ǥ ǤƬThe handbook of mentalization-based treatment ǡǤȋǤȌǡ ȋǤͳͺͷǦʹͲͲȌǤ ǡ ǣ Ƭ Ǥ ǡǤǤǡƬ ǡǤȋʹͲͲ͵ȌǤ ǣǡPsychology and Psychotherapy: Theory, Research and ǤPractice 76 ǡ ȋʹȌǡͳ͵ǦͳͳǤ ǡǤǡ ǡǤǡƬǡǤȋʹͲͲͺȌǤ ǣBehaviour research Ǥand therapy 46 ǡ ȋͳʹȌǡͳʹͷǦͳʹͺʹǤ ǡǤǡǡǤǡǡ ǤǡǡǤǡ ǡǤǡǡǤǡǤǤǤƬǡǤ ȋʹͲͳ͵ȌǤ ǣ The British Journal of Psychiatry 203 Ǥ ǡ ȋͳȌǡͷͺǦͶǤ ÚǡǤǡƬ ǡ ǤȋʹͲͲȌǤǤ AttachmentǦǡͳͷ and loss. ǦͳͲǤ ǡ ǤȋͳͻͺͲȌǤ ȋǤͳȌǤ ǡǣ JournalǤ of Brent, B.clinical (2009). psychology, Mentalization‐based 65 psychodynamic psychotherapy for psychosis. ȋͺȌǡͺͲ͵ǦͺͳͶǤ ǡǤǤǡƬ ǡǤȋʹͲͳͶȌǤǦSocial cognition and metacognition in Ǥ schizophrenia ȋǤʹͶͷǦʹͷͻȌǤǡǣ Ǥ ǡǤǤǡǡǤǤǡƬǡ ǤȋʹͲͳ͵ȌǤ PsychologicalǦǡ Medicine Ǧ43 ǣǦ Ǥ ǡ ȋͳʹȌǡʹͶͷǦʹͶͷǤ ǡ Ǥǡ̵ǡǤǡǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͲȌǤ ǣǫSchizophrenia Research 89 ǡ ȋͳǦ͵ȌǡʹͺǦʹͻʹǤ ǡǤǡǡǤ ǤǡƬǡSocial cognitive and affectiveǤȋʹͲͲȌǤ neuroscience 1 Ǥ ǡ ȋ͵ȌǡͳͷǦͳͶǤ
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±ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳȌǤ ǡǡ ǤFrontiers in human neuroscience 10 ǡ ǡͶͲǤ ǡǤǡǡǤ ǤǤǡǡǤǤǡ ǡǤǡǡǤǡǡ ǤǡǤǤǤ Ƭǡ Ǥ ǤǤȋʹͲͳͻȌǤ ȋ ȌPsychological Medicine, 49 Ǥ ȋʹȌǡ͵Ͳ͵Ǧ͵ͳ͵Ǥ ǡǤǡǡǤǤǡǡǤ ǤǡƬǡǤǤȋʹͲͳʹȌǤEarly intervention in psychiatry, 6(4) first‐ Ǥ ǡͶǦͶͺͲǤ 2 ǡǤǤ Ǥǡ ǡǤǡǡǤǤǡǡ ǤǡƬǡǤȋʹͲͳͳȌǤ Neuroscience & Biobehavioral Reviews 35 ǣ ǦǤ ǡ ȋ͵Ȍǡͷ͵ǦͷͺͺǤ Bulletin of ǡǤȋͳͻͺͻȌǤǤǤAnna Freud Centre, 12 ǡͻͳǦͳͳͷǤ ǡǤǡǡǤǡƬǡǤȋʹͲͳͷȌǤ ǣ Journal of personality disorders, 29 Ǥ ȋͷȌǡͷͷǦͲͻǤ The ǡǤǡƬǡǤȋʹͲͲȌǤBritish Journal of Psychiatry, 188 Ǥ ȋͳȌǡͳǦ͵Ǥ ǡǤǡƬǡǤȋʹͲͳͶȌǤ Psychotherapy 51 Ǥ ǡ ȋ͵Ȍǡ͵ʹǤ Comprehensive ǡǤǡƬǡǤǤpsychiatry 64 ȋʹͲͳȌǤǡ ǡǤ ǡ ǡͷͻǦǤ ǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͳȌǤ ǤBorderline personality disorder and Ǥ emotion dysregulation, 4 The cognitive neuropsycȋͳȌǡͳͳǤhology of schizophrenia ǡǤǤȋͳͻͻʹȌǤ Ǥǡǣ Ǥ Phenomenology ǡǤȋʹͲͲͷȌǤǣ Ǥand the cognitive sciences 4 ǡ ȋͳȌǡʹ͵ǦͶͺǤ ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͻȌǤ World Psychiatry, ǣ 18(2) Ǥ ǡͳͶǦͳͳǤ ǡǤǡƬǡ ǤȋʹͲͲͺȌǤ ǣ ǡ ǡǤ ǡǤǡ ¡ǡ Ǥ
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Psychosis, Trauma and Dissociation. Evolving Perspectives on Severe
Psychopathologyǡ ǤƬǡǤ Ǥǡ ǤǣͻǦͳͳǤ ǡǤ Ǥǡǡ ǤǤ Ǥǡ ǡǤǡƬ ǡǤȋʹͲͳͶȌǤ Acta Psychiatrica ǣǡ ǤScandinavica 129 ǡ ȋͶȌǡʹͷǦʹͶǤ ǡǤǡǡǤǡƬ ǡ ǤȋʹͲͲͷȌǤ ǣ ǤCognitive neuropsychiatry 10 ǡ ȋͶȌǡʹͶǤ Psychiatry ǡǤǤȋͳͻͻȌǤ Ǥ59 ǡ ȋ͵ȌǡʹͶǦʹͻǤ Ǧǡ Ǥǡ ǡ ǤǡǦǡǤǡǡǤǡǡǤ ǤȋʹͲͳͺȌǤ ǡSchizophrenia Research, ǡ Ǥ 202 ǡʹͲǦʹǤ ǡǤǡ ǡǤǤǡǡǤǤȋʹͲͲͻȌǤ ǡ Journal Behavioral Healthǡ Service Research, 36(3) ǣǤ ǡ͵ʹͲǦ ͵ʹͻǤ ǡǤǤǡǡǤǡǡǤǡǡǤǤǡǡǤǤǡ ǡǤ Ǥǡ ǡ Ǥ ǤȋʹͲͲȌǤ Psychiatry Research, 149, Ǧ Ǥ ͳ–ͺͲǤ ǡǤǤǡƬǡǤǤȋʹͲͳͶȌǤ ǣ The Lancet 383 ǦǦ Ǥ ǡ ȋͻͻʹͻȌǡͳǦͳͺǤ ǡ ǤǤǡ ǡǤ ǤǡǡǤ Ǥǡǡ ǤǡƬ ǡǤǤȋʹͲͳͶȌǤͷΨ ǣ Psychological medicine 44 Ǥ ǡ ȋͳȌǡʹͷǦ͵Ǥ ǡ Ǥǡǡ Ǥǡ ǡǤǡǡ ǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͳ͵ȌǤ ǣ ǡ ǡAmerican Journal of Psychiatry 170 Ǥ ǡ ȋȌǡ͵ͶǦͶͳǤ ǡǤǡƬ ǡǤȋʹͲͲȌǤ ǣ Trends in cognitive sciences 11 Ǥ ǡ ȋͷȌǡͳͻͶǦͳͻǤ ǡǤȋʹͲͳͷȌǤǣ ǤPersonality Disorders: Theory, Research, and Treatment 6 ǡ ȋͶȌǡ͵ͷǤ
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ǡǤǡǡǤǡǡ Ǥǡ ǡǤǡƬ ǡǤȋʹͲͳͷȌǤ Schizophrenia research, 161(2Ǧ ǣ-3) ǦǤ ǡͳͶ͵ǦͳͶͻǤ ǡ Ǥǡ ǡǤǡ ǡǤǡǦǡ ǤȋʹͲͳȌǤ Schizophrenia treatment.ǣ Ǥ Ǥ Lane, J. D., & Harris, P. L.Child (2015). development The roles of86 intuition and informants’ expertise in children's Ǥ ǡ ȋ͵ȌǡͻͳͻǦͻʹǤ 2 ǡǤǤǡ ǡǤǡ ǡ ǤǤǡǡǤǡ Ǧǡ Ǥǡ ǡ Ǥ ǤǡƬǡǤ Ǥ ȋʹͲͳȌǤ ǣ Expert Review of Neurotherapeutics, 17(11) Ǥ ǡͳͳͳǦͳͳ͵ͲǤ ǡǤǤǡƬǡǤǤȋʹͲͲͻȌǤ ǡJournalǦ ǡ of Autism and Developmental ǦǦ ǤDisorders 39 ǡ ȋͻȌǡͳʹ͵ͳǤ ǡǤ Ǥǡ ǡǤǤǡ ǡǤǤǡǡ Ǥǡ ǡǤǡ Ǧǡ ǤǡǤȋʹͲͲͷȌǤ Ǥ ǡͶ͵ȋʹȌǡ͵–ʹǤ ǡǤ ǤǡƬǡ ǤȋʹͲͳͶȌǤ ǣSchizophrenia Bulletin 40 Ǥ ǡ ȋ͵ȌǡͶͺǦͶͻͳǤ ǡǤǡƬǡ ǤȋͳͻͻͲȌǤ Attachment in the preschoolȀ years: Theory, research, Ǥand intervention 1 ǡ ǡͳʹͳǦͳͲǤ ǡ Ǥ Ǥǡ ǡǤ Ǥǡ ǡǤǡ ǡǤǡǡǤ ǤȋʹͲͳͶȌǤ ͳʹ Ǥ ǡͷͶȋͳȌǡͳͲͻ–ͳͳͷǤ ǡǤǤǡǡǤǤǡƬǡǤǤȋͳͻͻȌǤ Journal of personality and social psychology 73 Ǥ ǡ ȋͷȌǡͳͲͻʹǤ ǡǤȋͳͻͻȌǤ ǣ Journal of personality and social psychology 72 Ǥ ǡ ȋͷȌǡͳʹͳǤWorld ǡǤǡƬǡǤǤȋPsychiatry 11 ʹͲͳʹȌǤ Ǥ ǡ ȋͳȌǡͳͳǦͳͷǤ
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ǡǤǡǡǤǤǡ ǡǤǡ ǡǤǡǡǤǤǡƬǡǤǤȋʹͲͳ͵ȌǤ Frontiers in Human Neuroscience 7 Ǧ Ǥ ǡ ǡͺͳǤ ǡǤǤǡǡǤǡ ǡ ǤǡƬ ǡǤȋʹͲͳ͵ȌǤ Early intervention in psychiatry, 7(3) Ǥ ǡʹͺǦʹͺͶǤ ̵ ǡǤǡǡ ǤǡƬǡǤȋʹͲͳͶȌǤǡClinical Psychology Review 34 ǡǦǤ ǡ ȋȌǡ ͶͺʹǦͶͻͷǤ ǡǤǤǡ ǡ ǤǡƬǡǤȋʹͲͳ͵ȌǤClinical psychology & ǣ Ǥpsychotherapy 20 ǡ ȋȌǡͷʹ͵Ǧͷ͵ͲǤ ǡ Ǥ ǤǡƬ±ǡǤȋʹͲͳͺȌǤ Ǧ ǣ Schizophrenia and CommonǦ Ǥ ǡ Ǥǡ ǡ Ǥǡ Sense ǡ ǤȋǤȌ ȋǤͳͻ͵ǦʹͲȌǤǡǣ Ǥ ǡǤǤǡǡǤǤǡǡǤǤǡƬǡ ǤȋʹͲͲ͵ȌǤ American Journal of Psychiatry 160 Ǥ ǡ ȋͷȌǡͺͳͷǦ ͺʹͶǤ ǡ Ǥǡ ǡǤǡǡǤǡƬǡǤȋʹͲͳͶNeuropsychiatry 4 ȌǤ Ǥ ǡ ȋͳȌǡͷǤ ǡ ǤǡǡǤǡƬ ǡ ǤǤȋʹͲͳͻȌǤ Journal of Contemporary Psychotherapy, 49 Ǥ ȋʹȌǡͻǦͺͷǤ ǡ ǤǤǡǡǤǡǡǤǤǡƬSchizophrenia bulletinǦ ǡǤȋʹͲͳ͵ȌǤ39 ǣǤ ǡ ȋȌǡͳͳͺͲǦͳͳͺǤ Ǥǡ Ǥǡ Ǥǡ Ǥǡ Ö Ǥǡ ǤǡǤȋʹͲͲ͵ȌǤ ǫ Clinical Psychological Psychotherapy, 10(4), Ǥ ʹ͵ͺ–ͳǤ ǡǤǡ ǡǤǡǡǤǡ ǡ ǤǡƬǡ ǤȋʹͲͲȌǤThe British Journal of Psychiatry191 ǣǦǤ ǡ ȋͳȌǡͷǦͳ͵Ǥ ǡǤǤȋʹͲͲͷȌǤ ǣ ǡAttachment & human development 7 Ǥ ǡ ȋͶȌǡ͵ͶͻǦ͵Ǥ
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ǡǤǤǡǡǤ Ǥ ǤǡǡǤ ǤǡƬ ǡǤǤȋʹͲͳͷȌǤ Psychiatric rehabilitation Ǥjournal, 38(4) ǡ͵ʹͲǤ ǡǤǤǡǡǤǡǡǤǡƬǡǤǤȋʹͲͳȌǤǦ Psychiatric Ǥrehabilitation journal, 39(4) ǡ͵ͷʹǤ ǡ ǤǤǡƬǡǤǤȋʹͲͳͺȌǤǣ Emotion Review 10 Ǥ ǡ ȋʹȌǡͳͳǦͳʹͶǤ Dialogues in clinical neuroscience 2 ±ǡ ǤȋʹͲͲȌǤ Ǥ8 ǡ ȋͳȌǡͷͻǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳʹȌǤ ǣSchizophreniaǦ bulletin 38 Ǧ ǡ Ǧ Ǧ Ǥ ǡ ȋͶȌǡͳǦ ͳǤ ǡǤǡǡǤ ǤǡǡǤǡ ǡ Ǥǡ ǡǤǡǡǤǤǡǤǤǤ. The British JournalƬ ǡǤ of ȋʹͲͳͲȌǤ Psychiatry, 197 ȋͶȌǡʹͺǦʹͺͶǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬǡ ǤǤȋʹͲͳȌǤBMC psychiaǦ ǣ try 16 Ǥ ǡ ȋͳȌǡͳͻͳǤ ǡ Ǥǡ ǡǤǡǦǡǤǡǡ Ǥǡ ǡǤǡƬǡ ǤǤ ȋʹͲͳͺȌǤ Psychiatry research, 259, Ǥ Ͷ͵ǦͶͻǤ Ǥǡ Ǥǡ ǤǡǤǡǤǡǤȋʹͲͲͻȌǤ ͳͲPsychological Medicine, 39 Ǧ Ǧ Ǥ ǡͳͶͶǦͳͶͷǤ
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146807_JonasWeijers_BNW_def.indd 46 28-10-2020 15:08
PART II:
CHILDHOOD ABUSE
AND PSYCHOSIS
Part II Part
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Chapter Three: REPORTED CHILDHOOD ǣ FrontiersABUSE in Psychiatry AND(2018) STRESS JonasREACTIVITY Weijers1,2*, Wolfgang Viechtbauer 2, Elisabeth IN Eurelings -Bontekoe 3,, Jean-Paul Selten 1,2 PSYCHOSIS: A CONCEPTUAL REPLICATION AND AN EXPLORATION OF STATISTICAL APPROACHES 3
ͳ ǡǤ ʹ ǡ ǡǤ ͵ ǡ ǡǡǤ ȗJ.G. ǣ Weijers, W.V. Viechtbauer,ǡ E.H.Mͳͻǡ ʹ͵͵͵ǡȋ͵ͲͺȌǤ ǣEurelings-Bontekoe,Ǥ̷Ǥ J.-P.C.J.Ȁ̷Ǥ Selten
Frontiers in Psychiatry (2018) Chapter Chapter
146807_JonasWeijers_BNW_def.indd 49 28-10-2020 15:08 Chapter Three
Abstract
Ǧ Ǥ ǡ ǤͳȌ ʹȌ Ǥ ǦǦ ǡ ǡǦ ǤǦ ǡǦ Ǥ Ǥ Ǥ Keywords:
ǡ ǡ ǡ ǡǦ
Ǥ Introduction
Ǧ ȋǢǡǡ ǡƬǡʹͲͳ͵Ǣ ǤǡʹͲͳʹǢƬ ǡʹͲͲǢǤǡʹͲͳͷȌǤ ȋǦ ƬǡʹͲͲǢǡǦ ƬǡʹͲͲͺǢǡǡǦǡƬ ǡʹͲͳȌǤ this view, cumulative exposure to traumatic experiences during childhood results in ‘be sensitization’, a mechanism whereby previous exposure to adversity or stress renders individuals ǡ ȋǡǡǡƬǦ ǡʹͲͳ͵ǢǤǡʹͲͳǢǦ ǡ ƬǡʹͲͲͷȌ. Indeed, using the ‘experience sampling method’ (ESM), it was shown ȋǤǡʹͲͳ͵ȌǤ ǡ Ǥ ǡ Ǥ
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ȋȌ ȋ ǡ ǡƬǦ ǡʹͲͲǢ×ǦǤǡʹͲͳǢǤǡʹͲͳͺǢ ǡǡǡǡƬǦ ǡʹͲͳ͵ǢǤǡʹͲͳȌǤ ȋ ǤǡʹͲͲǢ×ǦǡʹͲͳǢǤǡʹͲͳͺȌǡ ȋǡǡǡǡƬǦ ǡʹͲͳͳȌ Ǧ ȋǤǤǡȌ ǦȋǤǤǡ activity’s difficulty exceeds one’s capability). SimǤ
ȋʹͲͳȌǡǡ ȋǤǤǡ 3 the participant’s current social situation) and areaǦȋǤǤǡ rticipant’s current neighborhood). Contrary to Lardinois et al. (ʹͲͳͳȌǡǡ ǤȋʹͲͳȌ Ǥ ǡ Ǥ ǡ Ǧ ǡȋʹͲͳȌȋʹͲͳͳȌ ǤǡǤȋʹͲͳͳȌ Ǧ Ǥ ǡǡ ȋ ǡʹͲͳʹȌǤǡǡ Ǧ Ǥ ǡ ȋǤǤǡ Ȍ ǦȋǡƬǡʹͲͳȌǡ ȋ ȌǤ ǡǦ ȋǡƬǡʹͲͳȌǤ ǤȋʹͲͳͳȌ Ǥ ǡ ǣǦǡ ǡ
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Ǥ ǡǦ ǡǦ ǡǦǤ Ǧ ǡ ǤǦǤ ȋʹͲͳȌ ‘Childhood xperience of Care and Abuse’ (Ȍ Ǥǡ ǦȋǤǤǡǤǡʹͲͳͺǡ ǤǡʹͲͳͳǢǤǡʹͲͳȌǤ ǡ ǡǡ ǡȋ Ƭ ǡʹͲͲ͵ǢǡƬ ǡʹͲͲǢƬ ǡʹͲͲͷȌǤ ǡȋǡǡ ǡ Ƭ ǡʹͲͲʹȌ ǦǦ ǡ Ǥ ǡǣͳȌ ǦǦ ʹȌ ǦǦ Ǥ Materials and methods Sample and procedure . ȋǤǡʹͲͳȌ ȋ ǡǡǡ ȌǤ ǡ ǡ ǡ ǡǡ Ǥ ȋ Ǣǡ Ƭǡ ͳͻͻʹȌǤ ǡ Ǥ ǡ Ǥ ǡ Ǧ ȋǤǤ Ǧ Ȍ
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Ǥ ȋ ̵ αͲǤͳ͵ȌǤ ǣͳȌͳͺǡʹȌ ǡ͵Ȍ ͳͲǤ ͳȌ ǡʹȌ ǡ͵Ȍ Ǥ Ǥ Measures. Ǧ Ǥ ǤǤȋʹͲͳͳȌǡ
ȋȌǤ 3 ȋǤǡʹͲͳͳȌǤ from the previous one by using an electronic diary device (called the ‘PsyMate’) to ȋ ȌǤ ȋǤǤǡ ǤǡʹͲͲǢǤǡʹͲͳͳȌǡ ǣ Ǥ Ǧ Ǥ ǡ (“I am not skilled to do this activity”), how difficult their current activity was (“This activity is difficult”), and to what they would rather engage in some other activity (“I would rather do something else”). The ǦǤǦ ǡ . Ǧ͵ȋȌ͵ȋȌ Ǥ ǣ ǡǡǡǡǤ ǣǡǡ ǡǡ ǡ ǡ experiencing that one’s thoughts are being influenced by others.Ǧ Ǥ ȋ͵Ȍǡ ȋͷȌǡ psychotic experiences (7 items), we computed Cronbach’s alpha values for the personǦ Ǧ ȋ
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p level). For activity stress, this yielded values of α=.71 and α=.46 for the person and beep levels, respectively. For negative affect, we found α=.93 and α=.69, respectively. Finally, for psychotic experiences, we obtained α=.91 and α=.70. The ‘ChildhoodExperience of Care and Abuse’ (CECA) instrument was used to assess RCA. ǡǦ Ͳ–16 years based on patients’ accounts. The CECA has been ȋ ǡƬ ǡͳͻͻͶȌǤ CECA by comparing sisters’ accounts of parental abuse, finding overall strong agreement between ǡ ȋǡ ǡ ǡ Ƭ ǡʹͲͲȌǤ ǣ ǡ ǡǡ Ǥ ǡ ǡǡǤ least bruising. Sexual abuse was defined as the participant’s report of any unwanted sexual ǡ Ǥ Ȁ Ǥ Ǥ ǦǦ ǣͲȋȌǡͳȋǣ Ȍǡʹ ȋ ǣǡȌǡ͵ȋǣȌǡͶ ȋǣȌǤ Ǧ ǣͲȋȌǡͳ ȋȌǡʹȋȌǡ͵ȋȌǡ ǡ Ǧ Ͷȋ ȌǤ Ǥ ǡͲͷʹǡ Ǥ ǡ ͷ Ǥ ǡǦ ͷData analysis. Ǧ Ǥ ǡ ǣ ȋͳȌ ȋʹȌǤ ǡ Ǥ ȋ ǤǡʹͲͲǢ ǡͳͻͻͺȌǤǦ ȋȌ Ǧ Ǧ Ǥ ǡ Ǧ
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Ǥǡ ǡǡ Ǥ ǡ ȋʹͲͳͳȌǤ ȋ Ǣ ȌǤ ȋ ǡƬǡʹͲͳͳǢ Ƭ ǡʹͲͲͺȌǤ ǡ ǡ
ȋǤǤǡ 3 εͳȌǤ ǦǦ ȋǤǤǡƬǡʹͲͲͳȌǤ ȋǤǤǡ ȌͲȋǤǤǡα –ͳȌǡ Ǧ Ǥ Ȁ ȋǤǤǡεͲǤαͲȌǦ Ȁ Ȁ ȋǤǤǡεͲȌǤǦ Ǧ ȋͷȌǤ ǡ ȋǤǤǡ Ȍ ǤǦ ǣ ȋ Ȍ Ȁ ȋ Ȍ Ȁ Ǥp ͻͷΨ ȋ Ȍ ǦǤ Ǧ Ǧ in AIC values. Analyses were carried out with SPSS 23, R 3.4.0 using the ‘nlme’ ȋ ƬǡʹͲͲʹȌand `lme4’ ȋǡ ǡƬǡʹͲͳͶȌ ǡȀ software 9.2, using the ‘proc glimmix’ and ‘proc nlmixed’ procedures. ǡ Ǧ ǡ Ǥ ǡ ǤǦ
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ǤȋʹͲͳͳȌǡ Ǧ ǡ ȋ ȌǤ Ǧ ǡ ȋǡ ȌǤǡǦǡ ǡ Ǥ ǡ Ǥ ǡ ȋȌǤ Ǧ Ǥ ǤʹǤͶʹǡ ǡ Ǥ
Results Sample characteristics
ǤͻͲǡ Ǥ ǤǡʹͳʹͲ ȋǤǡʹͲͳͳǡǤǡʹͲͳȌ Ǥ ͷͻ ǡSD ͳͻʹȋǡ͵ʹǤ Ǣ αͺǤǢǣʹͲǦͷͺȌǤ ͳǤPrimary analyses. Main effects. b p b
ȋp αͲǤͳͶǡͻͷΨ ȏͲǤͲͺǡͲǤʹͲȐǡ δͲǤͲͲͳȌȋ αͲǤͲͺǡͻͷΨ ȏͲǤͲ͵ǡͲǤͳʹȐǡb αͲǤͲͲͳȌ p Ǥ ȋ αͲǤͳͲǡͻͷΨ ȏͲǤͲǡͲǤͳͶȐǡ δͲǤͲͲͳȌ b ǡ ȋp αͲǤͲ͵ǡͻͷΨ ȏǦͲǤͲͲǡ ͲǤͲͷȐǡ ReportedαͲǤͲȌǤ childhood abuse and emotional stress reactivity. Ǥ ǡǡ ǡ Ǥ Ǥ
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b p
ȋ αͲǤͲ͵ǡͻͷΨ ȏͲǤͲͳǡͲǤͲȐǡb αͲǤͲʹȌǡp ȋReported childhood abuseαͲǤͲʹǡͻͷΨ ȏͲǤͲͲǡͲǤͲ͵Ȑǡ and psychotic stress reactivity.αͲǤͲȌǤ Ǥ b p ȋb αͲǤͲʹǡͻͷΨ ȏͲǤͲͲǡͲǤͲͶȐǡpαͲǤͲ͵Ȍǡ ȋ αͲǤͲͳǡͻͷΨ ȏͲǤͲͲǡͲǤͲʹȐǡ αͲǤͲ͵ȌǤ
3
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Table 1. Demographic and clinical characteristics of 59 patients with non-affective psychotic disorder who completed electronic diaries and reported on stress reactivity.
ȏȋȌǡȐ ͵ͳǤͺ͵ȋͻǤͶͲȌǡͳͻǦͷ ȏȀ ȋΨȌȐ ͵ͶȀʹͷȋͷǤΨȀͶʹǤͶΨȌ Ǧ ȏȋΨȌȐ ͵ͶȋͷǤΨȌ ͳͲȋͳǤͻΨȌ ͳͲȋͳǤͻΨȌ SD ͵ȋͷǤͳΨȌ ʹȋ͵ǤͶΨȌ ȋ Ȍǡ ESM Variables: ͷǤͳȋͶǤͲȌǡͳ SD , Ǧʹʹ ( nonmissing) observations ͳͲǤͳȋͳͳǤ͵ȌǡͲǦͶ͵ ȋ Ȍ
ʹǤͳȋͳǤͳȌǡͳǦ ͳͻͲͺ ͳǤͺʹȋͳǤͲͲȌǡͳǦ ͳͺͻ͵ Ǧ ͵ǤʹͷȋͳǤͶ͵ȌǡͳǦ ͳͺͺ Ǧ ʹǤͺͲȋͳǤʹͷȌǡͳǦ Note ͳͺͻͳ ǣ α Ǣα Ǣα Ǣα Secondary analyses.
Ǧ ȋǤǤǡ ͲȌǢ p ȋ ’s ≥ 0.20; see Table 2 for full results). However,b ȋp α ͲǤ͵ͻǡͻͷΨ ȏͲǤͲͻǡͲǤͲȐǡ αͲǤͲͳȌǤ ǡ ȋp ’s ≥ 0.12; see Table 3 for full results). ǡ p ȋ ’s ≤ 0.01; see Table 2 for ȌǤ ǡ Ȁp’ Ȁ ȋ s ≥ 0.22; see Table 2 for full results).
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146807_JonasWeijers_BNW_def.indd 58 28-10-2020 15:08 Reported childhood abuse and stress reactivity in psychosis
ǡǦ Ǧ Ǥ ͺǡ Ͷ Table 2. ResultsǦǤ of the two-part analysis of main and interaction effects on negative affect and psychotic experiences. Independent Dependent variable Estimate CI (95%) P- variable value or interaction
ȋǤǤαͲǤεͲȌ ͲǤͲ ǦͲǤ͵͵–ͳǤͷ͵ ͲǤʹͲ ȋǤǤαͲǤεͲȌ ǦͲǤͲͲ ǦͲǤʹͷ–ͲǤʹͶ ͲǤͻͺ
ȋǤǤαͲǤ ͲǤ͵ͻ ͲǤͲͻ–ͲǤͲ ͲǤͲͳ 3 εͲȌ ȋǤǤαͲǤ ǦͲǤͲͳ ǦͲǤʹͲ–ͲǤͳͻ ͲǤͻͷ εͲȌ ͲǤͳʹ ͲǤͲ–ͲǤͳ δͲǤͲͳ ȋǤǤεͲȌ ͲǤͲ ͲǤͲ͵–ͲǤͳͲ δͲǤͲͳ ȋǤǤεͲȌ ͲǤͳʹ ͲǤͲ–ͲǤͳͺ δͲǤͲͳ ȋǤǤεͲȌ ͲǤͲ ͲǤͲʹ–ͲǤͳʹ ͲǤͲͳ ȋǤǤεͲȌ ȗ ȋǤǤαͲǤεͲȌ ͲǤͳͶ ǦͲǤͲ͵–ͲǤ͵Ͳ ͲǤͳʹ ȗ ȋǤǤαͲǤεͲȌ ͲǤͲͶ ǦͲǤͲͻ–ͲǤͳ ͲǤͷ ȗ ȋǤǤαͲǤ ͲǤͲ ǦͲǤͲͶ–ͲǤͳͻ ͲǤʹͳ εͲȌ ȗ ȋǤǤαͲǤ ͲǤͲͲ ǦͲǤͲ–ͲǤͲ ͲǤͺͻ εͲȌ ȗ ͲǤͲʹ ǦͲǤͲͳ–ͲǤͲͶ ͲǤʹʹ ȋǤǤεͲȌ ȗ ͲǤͲͳ ǦͲǤͲͳ–ͲǤͲ͵ ͲǤ͵ ȋǤǤεͲȌ ȗ ͲǤͲͳ ǦͲǤͲʹ–ͲǤͲ͵ ͲǤͷͻ ȋǤǤεͲȌ ȗ ͲǤͲͲ ǦͲǤͲͳ–ͲǤͲʹ ͲǤͳ Note ȋǤǤεͲȌ ǣα
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Discussion
ȋʹͲͳͳȌ ǦǦǤ ǡǡ Ǥ Ǥǡ ǡ – –Ǧ Ǥ Ǧ ǡ Ǧ ǦǤ Ǥ ǡ ǡ Ǧǡ ǡǤ Ǥǡ Ǥ Ǥ n n ȋ αʹͳȌǡ ȋ α͵ȌǤ ǣ ǡ ȋ ǤʹͲͳȌǤ Ǧ ǡ Ǥ ǡǦ p ȋǡ Ƭ ǡͳͻͺȌ ȋ ’s > .18). ǡ Ǧ ǦǤ Ǥ ȋ ǡ ¡¡¡ǡǡƬǡʹͲͳȌǡ Ǥǡ Ǥ ǡ Ǣ ǤȋʹͲͳͳȌ heterogeneity of both studies is fairly similar. Patients in Lardinois et al.’s ȋʹͲͳͳȌ ͳͳͲǡͳͶͷ
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Ǥ ͳͲǡ ͳͻͷǤ ǡ Ǥ Ǧ ǡǤ ǡ Ǧ Ǧ absence Ǧ Ǧ Ǥ ǡ presence Ǧ Ǧ
3 Ǥ ǡ Ǧ ǡ Ǧ Ǥ ǡ Ǧ ǡ Ǥ ǡ Ǥǡ Ǥ Ǥ ǡ Ǥ Ǥ ǡ ȋǡ ƬǦ ǡʹͲͲͺȌǡȋƬǦ ǡʹͲͳͶȌǡ ȋǡǡǡƬǡʹͲͳͶȌ Ǥ ǡ ȋǤǡʹͲͳͳǢ ǤǡʹͲͳȌǤ ǡ ȋǤǡʹͲͳͳȌ Ǥ ǡ ͳǤͺͲͳǤͷͳ ͳ –Ǧ–Ǧ Ǥ ǡǡ Ǥ
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ȋǡƬ ǡʹͲͳȌ Ǥ ǡ Ǥ ȋʹͲͳͳȌǤ Ȁ ȋȌǡ Ǥ ǡ Ǥ Ǥ ȋ×ǦǤǡʹͲͳǢǤǡʹͲͳͺǢǤǡʹͲͳȌǤ ǡ ǡ Ǥ Ǥ ǡ ǡȋǡʹͲͲͻȌǤ ǡ Ǥ Ǥǡ Ǥ ǡ ǤǦ ǦǤǡ Ǥ Ethics statement
Ǥ ȋ ͳ͵Ǧ͵ǦͲǤͷȀȌǤ Ǥ Author’s contributions
Ǥ Ǥ Ǥǡǡ Ǥ Ǥ
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Conflicts of interest
Ǥ Funding
Ǧǡ Ǥ Acknowledgments
Ǥ 3 References
ǡǤǤǡ ǡǤǡƬǡǤȋͳͻͻʹȌǤArchives of general psychiatry, ȋ Ȍǣ 49 Ǥ ȋͺȌǡͳͷǦʹ͵Ǥ ǡǤǡǡ ǤǤǡƬ ǡǤǤȋͳͻͻͶȌǤJournal of Child Psychology and Psychiatry, 35ȋȌǣ Ǥ ȋͺȌǡ ͳͶͳͻǦ ͳͶ͵ͷǤ ǡǤǡ¡ ǡǤǡǡǤǡJournal of Statistical Software,ƬǡǤȋʹͲͳͶȌǤ Ǧ ͶǤ ǣͳͶͲǤͷͺʹ͵Ǥ Journal of clinical Brent, B.psychology, (2009). Mentalization‐based 65 psychodynamic psychotherapy for psychosis. ȋͺȌǡͺͲ͵ǦͺͳͶǤ ǡ ǤǤǡǡǤǤǡ ǡǤǤǡ ǡǤǤǡƬ ǡǤǤȋʹͲͲȌǤ Journal of affective ȋȌ disorders, 103 — Ǧ —ʹǤ ȋͳǦ͵ȌǡʹͳǦʹʹͶǤ ×Ǧǡ Ǥǡ ǡ Ǥǡ Àǡ Ǥǡ ǡ Ǥǡ Ǧ ǡ Ǥǡ ǡ ǤǤǡ Ƭ Ǧǡ Ǥ ȋʹͲͳȌǤ Focus , 14 Ǧ Ǥ ȋ͵Ȍǡ͵ͺǦ͵ͻͷǤ ǡ ǤǦǤǡǡ ǤǡǡǤ ǤǡƬǦ ǡ ǤȋʹͲͲȌǤJournal of psychosomatic Ǥ research, 6 ͳȋʹȌǡʹʹͻǦʹ͵Ǥ
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ǡǤ ǤǡǡǤ ǤǡStatistics inƬ medicine,ǡǤǤȋʹͲͳͳȌǤ 30 Ǥ ȋʹʹȌǡ ʹͻǦʹͲǤ ǡ Ǥǡ Ǧ ǡ Ǥǡ ǡ Ǥ (2008). Does the concept of “sensitization” provideSchizophren a plausibleia mechanism bulletin, 34 for the putative ǫClassification, data analysis, andȋʹȌ dataǡʹʹͲ highways.ǦʹʹͷǤ ǡ ǤȋͳͻͻͺȌǤǣǤ ǣǤ ǡ Ǥǡ ¡¡¡ǡǤǡǡ ǤǡƬǡ ǤȋʹͲͳȌǤEarly intervention in psychiatry, 11 izophrenia: A systematic review and meta‐analysis. ȋȌǡ Ͷͷ͵ǦͶͲǤ ǡ ǤǤǡƬ ǡ Ǥ ǤȋʹͲͲ͵ȌǤ Journal of Marketing Research, 40 Ǥ ȋ͵Ȍǡ͵Ǧ͵ͳǤ ǡǤǡǡǤǡǡǤǡǡ ǤǡActaƬ PsychiatricaǦ ǡ ǤȋʹͲͳͳȌǤ Scandinavica, 123 Ǥ ȋͳȌǡʹͺǦ͵ͷǤ ǡ Ǥǡ ǡ Ǥǡ ǡ Ǥǡ ǡ ǡ Ƭ Ǧ ǡ Ǥ ȋʹͲͳ͵ȌǤ ǣPsychological Medicine, 43 Ǥ ȋȌǡͳ͵ͺͻǦͳͶͲͲǤ ǡ ǤǤǡ ǡ ǤǡSchizophrenia ǡ ǤǤ ȋͳͻͺȌǤ bulletin, 13 ȋȌ Ǥ ȋʹȌǡʹͳǦʹǤ ǡǤǤǡǡǤǤǡ ǡǤǤǡPsychologicalǡǤǤǡƬ medicineǡǤ ǤȋʹͲͳ͵ȌǤ, 43 ǣ ǦǤ ȋʹȌǡʹʹͷǦʹ͵ͺǤ ǡ Ǥǡ Ƭ ǡ Ǥ ȋʹͲͲȌǤ ǣSchizophrenia bulletin 33 ǣ — Ǥ ǡ ȋͳȌǡ͵ǦͳͲǤ Ǧ ǡ ǤǡǡǤǡPsychological medicine,Ƭǡ ǤȋʹͲͲͷȌǤ 35 Ǥ ȋͷȌǡ͵͵ǦͶͳǤ Ǧ ǡ ǤǡƬǡ ǤȋʹͲͲȌǤClinical psychology review,Ǧ ǣ 27 Ǥ ȋͶȌǡͶͲͻǦͶʹͶǤ ǡǤǤǡƬJourn ǡ ǤǤȋʹͲͲͳȌǤal of the American StatisticalǦ Association,Ǧ 96 Ǥ ȋͶͷͶȌǡ͵ͲǦͶͷǤ Ǥ ȋʹͲͳʹȌǤ ǡPerspectives Ǧ ǡ on Psychological Science, 7 Ǥ ȋȌǡͷMixedǦͲǤ- ǡ ǤǤǡeffectsƬ modelsǡǤǤȋʹͲͲʹȌǤ in S and S-Plus Ǧ ǣ Ǥ ǤǣǤ
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ǡǤǡǡǤ ǤǡǡǤǡǡǤǤǡ ǡǤǡǡǤǡǤǤǤǡ ƬǡǤ ȋʹͲͳȌǤǡ ǡ ǣSchizophrenia bulletin, 42 Ǥ ȋ͵ȌǡͳʹǦʹʹǤ ǡǤǡǡǤ ǤǡƬǡǤȋʹͲͲȌǤ Statistics in medicine, 25 ǣǤ ȋͳȌǡͳʹǦͳͶͳǤ ǡ ǤǤǡActaƬ PsychiatricaǦ ǡǤȋʹͲͳͶȌǤ Ǥ Scandinavica, 129 ȋȌǡͶͻǦͶͺͲǤ ǡ Ǥǡ Ƭ ǡBehavioral Ǥ ȋEcology,ʹͲͲͺȌǤ 20 ǣ Ǥ ȋʹȌǡͶͳǦͶʹͲǤ ǡǤǡǡǤǤǡǡǤǡƬǡǤȋʹͲͳͶȌǤ
ǣPsychiatry research, 217 3 Ǥ ȋ͵ȌǡʹͲʹǦʹͲͻǤ ǡǤǤǡǡǤǡ ǡ ǤǤǡ ǡ ǤǤǡBritish Medical Jorunal, 324Ƭ ǡǤǤȋʹͲͲʹȌǤǦ Ǥ ȋ͵ͶȌǡͳͳͻ͵ǦͳͳͻͶǤ ǡǤǡǡǤǤǡƬǡ ǤǤȋʹͲͳȌǤ ǣPloS one, 11 Ǥ ȋͳͳȌǤ ǡǤǡǡǤǡ ǡ ǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡ ǤȋʹͲͳȌǤ European Psychiatry, 45 ǫ ǡͳǦͳ͵Ǥ ǡǤǤǡǡǤǡ ǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬǦ ǡ ǤȋʹͲͳͷȌǤ Psychological Medicine 4 Ǥ ǡ ͷȋȌǡͳ͵͵Ǧͳ͵Ǥ ǡǤǡ ǡǤǡǦ ǡ ǤǡǡǤǡ ǡǤǡ ǡǤǡǡǤǡǡǤǡ ǡ ǤǡƬǡǤȋʹͲͳͺȌǤ Psychiatry research, 1 ǡǡ Ǥ ȋʹͲȌǡͶͷͳǦ ͶͷǤ ǡǤǡǡǤǤǡƬǦ ǡ ǤȋʹͲͲͺȌǤ Ǥ Schizophrenia bulletin, 34 Ǧ Ǥ ȋȌǡͳͲͻͷǦͳͳͲͷǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡǤǤȋʹͲͳʹȌǤ ǣSchizophrenia bulletinǦ, 38 Ǧ ǡ Ǧ Ǧ Ǥ ȋͶȌǡͳǦͳǤ
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ǡ Ǥǡ ǡ Ǥǡ Ǧǡ Ǥǡ ǡ Ǥǡ Ƭ ǡ Ǥ ȋʹͲͳPsychologicalȌǤ medicine, ǡ 46 ǣǤ ȋͳȌǡ͵͵͵ͻǦͶͺǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬǡ ǤǦǤȋʹͲͳȌǤBMC psychiatryǦ ǣ , 16 Ǥ ȋͳͻͳȌǤ ǡ ǤǤǡ Ƭ ǡ Ǥ Ǥ ȋʹͲͲͷȌǤJournal ǡ of Family ǡ Psychology, 19 Ǥ ȋͳȌǡͳͳͳǦͳʹͲǤ
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146807_JonasWeijers_BNW_def.indd 67 28-10-2020 15:08
146807_JonasWeijers_BNW_def.indd 68 28-10-2020 15:08
Chapter Four: THE RELATIONSHIP Schizophrenia Research (2019)ǣ
LisaBETWEEN Steenkamp1,2,3,4*, Jonas Weijers 1 ,5CHILDHOOD, Jorinde Gerrmann1,2,6,7, Elisabeth Eurelings -Bontekoe2, & Jean- PaulABUSE Selten1,5 AND SEVERITY OF PSYCHOSIS IS MEDIATED BY LONELINESS: AN EXPERIENCE SAMPLING STUDY
1 4
ǡ ʹ ǡǡ ͵ Ȁ ǡ Ǧhildren’s ǡǡǤ Ͷ ǡ ǡǡǤ ͷ ǡ ǡǤ ̵ͶͷǡǤ L. ǡ ǡ Steenkamp, J.G. Weijers, J. Gerrmann, Ǥ ȗ E.H.M Eurelings-Bontekoe,ǣǡ J.-P.C.J.Ǥ Selten ͶͲǡ͵Ͳͳͷ Ǥ ǣǤ̷ Ǥ
Schizophrenia Research (2019) Chapter Chapter
146807_JonasWeijers_BNW_def.indd 69 28-10-2020 15:08 Chapter Four
Abstract Background.
ȋȌ ǢȋȌ Ǧ ǤMethods. ǦǦ ǡǡ ȋ ȌǤ ‘Childhood Experience of Care and Abuse’ interview. ǡ ǤResults. ǡ b = p ȋ ͲǤͲͺǡͻͷΨ ȏͲǤͲʹǡͲǤͳ͵Ȑǡ αͲǤͲͲͷȌǤ ǡ b p b Ǧ = ȋ αͲǤͲͶǡͻͷΨ ȏͲǤͲʹǡͲǤͲȐǡ δͲǤͲͲͳȌȋ αͲǤͲʹǡͻͷΨ ȏͲǤͲͳǡͲǤͲ͵Ȑb = ǡ ͲǤͲͲʹȌǤȋp ͲǤͲʹǡͻͷΨ ȏͲǤͲͲǡ ͲǤͲͶȐǡConclusionsαͲǤͲʹȌǤ. Ǥ Keywords: Ǣ Ǣ ǢǢǢǦ Ǥ Introduction
ȋǤǡʹͲͳͳǢǡ ǡ ǡƬ ǡʹͲͲͺǢǡǡ ǡǡƬǡʹͲͳ͵Ǣ ǤǡʹͲͳʹȌǤ Ǧǡ ȋƬǡʹͲͲͺǢ ǡǡƬǡʹͲͳȌ ǡ ǡ ǡǡǡƬǡʹͲͲͷǢǤǡʹͲͳͶȌǤ ȋƬǦ ǡʹͲͲͷǢǡǡǡƬǦ ǡʹͲͳ͵ȌǤ ǡ Ǧ
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ȋǤǡʹͲͳǢǤǡ ʹͲͳͶȌǤ ȋǡ ƬǡʹͲͳͷǢǤǡ ʹͲͳͶȌǤ ȋ Ƭ ǡͳͻͻǢƬ ǡʹͲͳ͵ǢǡǡǡƬ ǡ ʹͲͳ͵Ȍ Ǧ ȋǤǡʹͲͳ͵ȌǤ ǡ Ǧ ȋ ǡ ǡƬ ǡʹͲͳȌǤ ǡ
ȋ ǦƬǡʹͲͳ͵Ǣ ǤǡʹͲͳǢǡ 4 ǡǡƬǡʹͲͳͲȌǤ ȋ ǡʹͲͲȌ ȋƬǡͳͻͺͺǢǤǡ ʹͲͲͺȌǤ ǡ ǡ ǡ Ǥ Ǥ ǡ ȋǤǡʹͲͳͷȌǤ Ǧ ǡ ȋƬ ǡ ʹͲͳͷȌǤ ǡ ȋ ǡ ǡǡ ǡƬ ǡʹͲͳǢòǡ ǡǡǡƬǡʹͲͳͶȌǤ ȋ ǡ ǡƬ ǡʹͲͳͲǢ ǡ ǡǡ ǡƬǤʹͲͲǢǤǡʹͲͳ͵Ǣǡ ǡǡƬ ǡʹͲͳȌ ȋǡǡƬǡʹͲͲʹǢ ǤǡʹͲͳͳǢ ǤǡʹͲͲͷǢ ¡ǤǡʹͲͲͷǢǤǡʹͲͳͶǢǡ ǡƬ ǡʹͲͲȌǤ
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ǡȋȌǦ Ǣ ȋȌ Ǧ Ǥ ǡǡǦ Ǧ Ǥ ȋȌǡǦ ȋ ǡ ǡƬǡʹͲͲǢǦ ǡǡƬǡʹͲͲͷȌǤ Material and Methods Subjects.
ǡǤǡʹͲͳ ͻͲ Ǧ ȋȌ ȋǡǡǡȌǤ Ǥ ǡ ǡ ǡ ǡǡ ȋȌǤ ȋǡ ƬǡͳͻͻʹȌǤ ͳͺ Ǥ ͳͲǤ ȋͳȌ ǡȋʹȌ ǡȋ͵Ȍ ǤDesign. ǡ Ǥ ȋ ‘PsyMate’) Ǥ ȋ ȌǤ ǡǡ ȋǡ ǡƬMaterialsǡʹͲͲʹǢ. ǤǡʹͲͲǢǤǡʹͲͳͳȌǤ Childhood Experience of Care and Abuse (CECA):
We used the ‘Childhood Experience of Care and Abuse’ (CECA) interview to measure childhood abuse retrospectively ȋ ǡǡƬ ǡ ͳͻͻͶȌǤǦ
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ͳǤ ǣ ǡ ǡǡ Ǥ Ǥ ǦǦ ǣȋͲȌǡȋͳȌǡ ȋʹȌǡ ȋ͵ȌǡȋͶȌǤ Ǧ ǣȋͲȌǡȋͳȌǡ ȋʹȌǡȋ͵Ȍǡ ǡ Ǧ ȋͶȌǤ Ǥ ͲͷʹǤ ǡ ǡ Ͳͳʹ ͲͳǤ ǡ Ǥ ǡǦ Ǧ ǤESM measures:
Ǧ Ǥ 4 ȋ ǡǡ ǡ ǡ that others want to hurt him/her, feeling disliked, and thinking that one’s ȌǤsingle items “I feel down” and “I feel anxious”. Loneliness was assessed by the single item “I feel lonely”, which is a ȋƬ ǡʹͲͳͷǢǡͳͻͺǢò ǤǡʹͲͳͶȌ ȋ ǡǡǡƬ ǡʹͲͳȌǤ ͳStatistical Analyses. ǦǤ ȋͺȌǤ ʹǦαǤͲͷǤ ǣ ȋͳȌ ȋʹȌǤʹ ͳȋȌǤ ǡ ǡ Ǥ ǡ ȋȌȋ ǡǡƬǡʹͲͳͲȌǤ ǦǦ ǡ ǡ Ǥ
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ȋ Ȍ Ǥ Ǧ ǤʹǦͳǦͳȋ ǤǡʹͲͳͲȌ ȋ ͳȌǤǡͳǦͳǦͳȋ ǤǡʹͲͳͲȌ Ǥ ǦǦ ͳȋ ȌǤǦ Ǧ Ǥ ͳǦȋͳǦͳȌǦͳȋ ǤǡʹͲͳͲȌȋ ʹȌ Ǥ
Figure 1.
Level 2: Subjects Childhood abuse X c’
Level 1: ESM observations a
b w Positive Loneliness M symptoms Y bb
Figure 1.
ʹǦͳǦͳ ǤαǡαǡαǢαǦ Ǣc’αǦ Ǣ αǦ Ǣ αǦ Ǥ Figure 2
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146807_JonasWeijers_BNW_def.indd 74 28-10-2020 15:08 The relationship between childhood abuse, psychosis and loneliness
Level 2: Subjects Level 1: ESM observations Feeling down ab M bb a b w c ’ w w Positive Loneliness X c ’ symptoms Y a b b w w ab Feeling bb anxious M
Figure 2.
ͳǦȋͳǦͳȌǦͳ X M Y Ǥab a cb’ αǡ αǡcw’ α bw b bb b
Ǣ αǦ Ǣ αǦ Ǣ αǦ 4 ǢResults αǦ Ǣ αǦ Ǥ Sample.
ͻͲ ǡͻ ʹͳ ʹͲǡȋ ǡǡƬǦ ǡʹͲͲǢǡǡǡƬǦ ǡʹͲͳͳȌǤ ǡ Ǥǡ ͷͻ Ǥ ȋʹͲǢͳǤͲΨȌǡ ȋʹͻǢͳǤͷΨȌǡȋͳͺǢͲǤͻΨȌǡȋ͵ͳǢ ͳǤΨȌǤ Ǥ ͵ͳǡ ͳͺͻȋͳͻʹ–͵ͳαͳͺͻȌ Ǥ ͳ Ǥ ǡͶ͵ ȋʹǤͻΨȌ Ǣ͵Ͷ ȋͷǤΨȌ ǡͳͷ ȋʹͷǤͶΨȌ ǡͳͷ ȋʹͷǤͶΨȌ ǡ subjects (11.9%) experienced sexual abuse. Table 2 depicts the means, standard deviations, ICC’s, Ǥ Table 1.
ȋαͷͻȌǤ
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M SD n ǡ ȋ Ȍǡ n ͵ͳǤͺȋͻǤͶȌǡͳͻǦͷ ǡ ȋΨȌ ͵ͶȋͷǤΨȌ Ǧ ǡ ȋΨȌ ͵ͶȋͷǤΨȌ ͳͲȋͳǤͻΨȌ ͳͲȋͳǤͻΨȌ M SD ͵ȋͷǤͳΨȌ M SD ʹȋ͵ǤͶΨȌ ǡ ȋ Ȍǡ ͷǤȋͶǤͳȌǡͳǦʹʹ ǡ ȋ Ȍǡ ͳͲǤͳȋͳͳǤ͵ȌǡͲǦͶ͵ ͷǤͶȋͷǤͻȌǡͲǦͳ ͳǤȋ͵ǤͷȌǡͲǦͳʹ Note. ͳǤͻȋ͵ǤȌǡͲǦͳʹ ͲǤ͵ȋͲǤͺȌǡͲǦ͵ ǣͲǦͷʹǡ ͲǦͳǡ ͲǦͳʹǡ ͲǦͳʹǡͲǦͳʹǤ Table 2. ǡ ǡ
Ǥ ȋȌǡ Ȁ ʹǤͲͳȋʹǤʹͶȌǡͲǦͺǤ ͲǤ͵ʹ ͲǤʹͺ ͲǤͶͲ ͲǤʹ ͲǤͶ ʹǤ͵ȋͳǤͷͻȌǡͳǦ Ǧ ͲǤͳ ͲǤ ͲǤ ͳ ͲǤ ͳǤͺʹȋͲǤͻͻȌǡͳǦǤ͵ ͲǤʹʹ Ǧ ͲǤͺ ͲǤ͵ ͲǤͷ ʹǤͶͳȋͳǤͷȌǡͳǦ ͲǤ͵͵ ͲǤ͵ Ǧ ͲǤͺͳ Ͳ ͲǤͷ Note. ͳǤͻͳȋͳǤ͵͵ȌǡͳNǦ ͲǤʹͶ ͲǤ͵Ͳ ͲǤ͵ʹ Ǧ N = ʹ Ǧ ȋ αͳͺͻȌǤǦ ȋ ͷͻȌǤ α Ǥ ͷ Ǥ ͲǦͳͲǤͶǢͳǦǤ
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The mediating role of loneliness.
Ǥ͵Ψ Ǧ ǡʹǦͳǦͳǦ Ǥa p ȋ αͲǤͳͷǡͻͷΨ ȏͲǤͲͷǡͲǤʹͶȐǡ αͲǤͲͲʹȌǤbb ǡ p ȋ αͲǤͷͶǡͻͷΨ ȏͲǤ͵ǡͲǤʹȐǡ δ ͲǤͲͲͳȌǤǡbw Ǧ p ȋ αͲǤͲͺǡͻͷΨ ȏͲǤͲͷǡͲǤͳʹȐǡ δͲǤͲͲͳȌǤ ab = p ȋ ͲǤͲͺǡͻͷΨ ȏͲǤͲʹǡͲǤͳ͵Ȑǡ αͲǤͲͲͷȌǤ c’ ǡ p ȋ αǦͲǤͲͳǡͻͷΨ ȏǦͲǤͳͳǡͲǤͲͻȐǡ αͲǤͺʹͶȌǤThe mediating role of depressive and anxious symptomatology. ͵Ǥ 4 ͶͳǤʹΨ Ǧ ͷͺǤͺΨǦ ǡ ͳǦͳǦͳǦ Table 3.Ǧ Ǥ
Ǥ SE SE ͻͷΨ ͻͷΨ Within-subject level aw bw cw’ ͲǤ͵Ͳȗȗȗ ͲǤͲͶ ͲǤʹʹǡͲǤ͵ ͲǤͳͻȗȗȗ ͲǤͲ͵ ͲǤͳʹǡͲǤʹ abw ͲǤͳ͵ȗȗȗ ͲǤͲʹ ͲǤͳͲǡͲǤͳ ͲǤͳʹȗȗȗ ͲǤͲ͵ ͲǤͲǡͲǤͳ ͲǤͲͶȗȗ ͲǤͲʹ ͲǤͲͳǡͲǤͲ ͲǤͲȗȗȗ ͲǤͲʹ ͲǤͲ͵ǡͲǤͳͲ
abw1/w2ȋα ͲǤͲͶȗȗȗ ͲǤͲͳ ͲǤͲʹǡͲǤͲ ͲǤͲʹȗȗ ͲǤͲͳ ͲǤͲͳǡͲǤͲ͵ Ȍ ͳǦȋͳǦͳȌǦ ͲǤͲͶȗȗȗ ͲǤͲͳ ͲǤͲʹǡͲǤͲͷ ͲǤͲʹȗ ͲǤͲͳ ͲǤͲͲǡͲǤͲ͵ Betweenͳ-subject level ab bb ͲǤͺͳȗȗȗ ͲǤͳʹ ͲǤͷǡͳǤͲͷ ͲǤʹȗȗȗ ͲǤͳͳͺ ͲǤ͵ͻǡͲǤͺͷ cb’ ͲǤͳͷ ͲǤͳͻ ǦͲǤʹʹǡ ͲǤ͵ͺ ͲǤʹ ǦͲǤͳǡͲǤͻʹ abb ͲǤͷ ͲǤ͵Ͳȗ ͲǤͳ͵ ͲǤͲͷǡͲǤͷͷ ͲǤʹ ͲǤͳͷͶ ǦͲǤͲͶǡͲǤͷ
abb1/b2ȋα ͲǤͳʹ ͲǤͳ ǦͲǤͳͻǡ ͲǤʹ͵ ͲǤͳͺͳ ǦͲǤͳʹǡͲǤͷͻ Ȍ ͲǤͶͶ Note. ȋα ͲǤͲʹ ͲǤͳʹ ǦͲǤʹʹǡ ab a w ͲǤͳͷ ͲǤͳʹͳ→ ǦͲǤͲͻǡͲǤ͵ͻbb bw ȌͳǦȋͳ→ǦͳȌǦͳ cb’ cw’ ͲǤʹ → p p p Ǣ Ȁ α Ǣ Ȁ α Ǣ Ȁ α Ǥ ȗ δǤͲͷǤȗȗ δǤͲͳǤ ȗȗȗ δǤͲͲͳǤ
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Within-subject effects.
p aw ȋ δͲǤͲͲͳǢ͵ǡ ȌǤ ǡp bw ȋ δͲǤͲͲͳǡ͵ǡ ȌǤ abw Ǧ p abw ȋp αͲǤͲͶǡͻͷΨ ȏͲǤͲʹǡͲǤͲȐǡ δͲǤͲͲͳȌǡȋ αͲǤͲʹǡ ’ ͻͷΨ ȏͲǤͲͳǡͲǤͲ͵Ȑǡ αͲǤͲͲʹȌǤǦ cw ’ ȋp cw p αͲǤͲͶǡ ͻͷΨ ȏͲǤͲͳǡͲǤͲȐǡ αͲǤͲͲͷȌȋ αͲǤͲǡͻͷΨ ȏͲǤͲ͵ǡͲǤͳͲȐǡ δͲǤͲͲͳȌǤ abw1 p abw2 ȋ αͲǤͲͶǡͻͷΨ ȏͲǤͲʹǡͲǤͲͷȐǡp δͲǤͲͲͳȌȋ α ͲǤͲʹǡͻͷΨ ȏͲǤͲͲǡͲǤͲ͵Ȑǡ αͲǤͲͳʹȌabw1 abw2 Ǥȋp Ǧ αͲǤͲʹǡͻͷΨ ȏͲǤͲͲǡͲǤͲͶȐǡBetween-subject effects.αͲǤͲʹȌǤ ǡ p ab ȋ δͲǤͲͲͳǢ͵ǡ ȌǤ ǡ ǡp bb ȋ εͲǤͲͷǢ͵ǡ ȌǤ Ǧ p abb ȋ εͲǤͲͷǢ͵ǡ ȌǤ Discussion
Ǥ Ǥǡ Ǥ ǡǡǦ Ǥ ǡ ǡ ȋǦ ȌǤ Ǥ ǡ ȋComparison to previous findings. Ǧ ȌǤ
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ȋǤǡʹͲͳͷȌǦ ȋƬ ǡʹͲͳͷȌǤ ȋǤǡʹͲͳͳǢǤǡ ʹͲͲͺǢǡǡ ǡǡƬǡʹͲͳ͵ǢǤǡʹͲͳʹȌ ȋ Ƭ ǡͳͻͻǢƬ ǡʹͲͳ͵ǢǤǡ ʹͲͳ͵Ȍǡ ȋ ǤǡʹͲͳȌǤ ǡ Ǥ ȋ ǤǡʹͲͳǢòǤǡʹͲͳͶȌǤ ǡ Ǧǡ Ǥ Ǧ ǡǦ ǡȋƬ 4 ǡʹͲͲͻȌǤǦ ǡ Ǥ ǡ Ǧ ǡ ȋǡʹͲͲǢƬǡʹͲͳͳǢ ǡʹͲͳʹǢǡʹͲͲͶȌrelative ǤǦ ǡ – ed to feel more lonely than their “baseline” – Ǧ Ǥ ȋǤǡ ʹͲͳ͵ȌǤ ǡ ǡ ȋǤǡ ʹͲͳȌǡȋ ǤǡʹͲͳͶȌǡȋǤǡʹͲͳȌ Ǥǡ ǡ Strengths and limitations. ȋ ƬǡʹͲͳͶȌǤ Ǥ ȋǦ ǤǡʹͲͲͻȌǤǡ ǦǦǦȋ ǤǡʹͲͳͲȌǤ ǦǦ Ǥ Ǧ
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Ǧ Ǥ Ǥ ǡ ǡ ȋǤǡ ʹͲͳͺȌǤ ǡ ȋƬǡʹͲͳʹȌǤ ǡ ȋǤǡʹͲͳͲǢ ǤǡʹͲͳ͵ǢƬGayer‐Anderson, 2016; Varese et al., 2012)Ǥ ǡ Ǧ Ǥ ǡǡ Ǥǡ Ǧreport instruments. Their validity depends upon the patients’ Ǥ Ǧ ȋǡ ǡ ǡ ǡConclusion.ƬǡʹͲͲȌ Ǥ ȋȌ ǢȋȌ Ǧ Ǥ References
ǡǤǤǡ ǡǤǡƬǡǤȋͳͻͻʹȌǤ ȋ Ȍǣ ǤArchives of general psychiatry, 49 ȋͺȌǡͳͷǦʹ͵Ǥ ǡǤǤǡƬǡǤȋͳͻͺͺEuropeanȌǤ Archives of Psychiatry and Clinical Neuroscience , Ǥ238 ȋͳȌǡͶǦͷͶǤ ǡǤǡǡǤǡ ǡ ǤǤǡ ǡ ǤǡǡǤǤǡƬǡǤȋʹͲͳͳȌǤ ̵ American Journal of Psychiatryǣ , 168 Ǥ ȋͳȌǡͷǦʹǤ ǡǤǡ ǡ Ǥǡ ǡǤǡǡǤǡƬǡ ǤȋʹͲͲȌǤǦ ǫPsychiatry research, 151 ǦǤ ȋͳȌǡ͵ǦͶǤ ǡǤǡ ǡ Ǥ Ǥǡ ǡǤǤǡƬ ǡǤǤȋʹͲͲͺȌǤ Schizophrenia bulletin, 34 ǣ ǡ Ǥ ȋ͵Ȍǡ ͷͺǦͷͻǤ
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ǡǤǡǡ ǤǤǡƬ ǡǤǤȋͳͻͻͶJournalȌǤ ȋȌǣ of Child Psychology and Psychiatry, 35 Ǥ ȋͺȌǡ ͳͶͳͻǦͳͶ͵ͷǤ ǡǤǡƬ ǡǤȋʹͲͳͷPsychiatryȌǤ research, 226 Ǧ Ǥ ȋͳȌǡ͵Ǧ͵ͺʹǤ ǡ ǤǤǡ ǡǤǤǡƬǡǤǤȋʹͲͳͲȌǤ ǣͷǦ Ǧ ǡǡ Ǥ ʹͷȋʹȌǡͶͷ͵Ǥ ǡ ǤǤǡ ǡǤǤǡǡǤ Ǥǡ ǡǤǤƬǡǤǤȋʹͲͲȌǤ Psychology and aging, 21 ǣ Ǧ Ǥ ȋͳȌǡͳͶͲǤ ǡǤǤȋʹͲͲȌǤǣ ǡ ǡ Ǥ ǡͷǡͷͲͷǦͷʹͺǤ ǡǤ ǤǡƬǡǤ ǤȋʹͲͳͳȌǤAnnual reviewǦ of psychology, 62 Ǧ 4 Ǥ ǡͷͺ͵ǦͳͻǤ ǡǤǤǡǡǤǤǡǡ ǤǤǡǡǤǤǡǡǤǤǡƬǡ ǤȋʹͲͳͲȌǤ ǤArchives of general psychiatry, 67 ȋͳͳȌǡͳͳͳͶǦͳͳͳͻǤ ǡǤǡǡǤǡƬǡ ǤSocialȋʹͲͲʹ psychiatryȌǤ and psychiatric epidemiology, 37 Ǥ ȋ͵ȌǡͻǦͳͲͶǤ ǡǤǡ ǡǤǤǡ ǡǤǡ ǡǤǡǡǤǤǡǡǤǤǡǡ ǤǦ Ǥǡ ǡǤǤǡǡǤǡƬ ǡǤȋʹͲͳȌǤ ǣ ǤSchizophrenia bulletin 43 ȋʹȌǡʹͻ͵Ǧ͵ͲͳǤ ǡǤǡǡǤǤǡ ǡǤǤǡǡ Ǥǡ ǡǤǤǡǡǤǡǦǡǤǤǡ ǡǤǤǡ ǡǤǡƬ ǡ ǤȋʹͲͳSchizophreniaȌǤ research, 176 Ǥ ȋʹȌǡͳͳǦ ͳǤ ǡǤǡ ǡ Ǥǡ ǡǤǡ ǡǤǡǡǤǡǡ ǤǡǡǤǡƬǡ ǤǤȋʹͲͳͳȌǤ ǡǡǣSchizophrenia bulletin Ǥ ǡͲͳͻǤ ǡǤǡ ǡǤǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡ ǡǤǡ ǡ Ǥǡ ǡǤǡƬǡ ǤȋʹͲͲͷThe JournalȌǤ ǣ of nervous and mental disease, 193 Ǥ ȋͷȌǡ͵ͲͻǦ͵ͳͷǤ ǦǡǤǡƬǡǤȋEpidemiologyʹͲͳ͵Ȍ Ǥ ǡ ǣand Psychiatric Sciences, 22 Ǥ ȋͲʹȌǡͳ͵ͳǦͳͶǤ
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ǡǤǡǡ ǤǡǡǤǡ ǡǤǡǡ ǤǡƬǡ ǤǦǤȋʹͲͳͶȌǤ JAMA psychiatry, 71 Ǥ ȋͳʹȌǡ ͳ͵ͶǦͳ͵ʹǤ ǡǤǤǡƬ ǡǤǤȋChildͳͻͻ AbuseȌǤ & Neglect, 20 Ǥ ȋͳͳȌǡͳͲͺǦͳͲͻ͵Ǥ ǡ ǤǦǤǡǡ ǤǡǡǤ ǤǡƬǦ ǡ ǤȋʹͲͲȌǤ Journal of psychosomatic research, 61 Ǥ ȋʹȌǡʹʹͻǦʹ͵Ǥ ¡ǡ ǤǡǡǤǡǡ Ǥǡ ǡǤǡ ǡǤǡƬÚ ǡǤȋʹͲͲͷȌǤ ǣ Schizophrenia — ǡ Ǥresearch, 77 ȋͳȌǡͳͳǦʹͶǤ ǡǤȋHandbookʹͲͳʹ ofȌ. Whyresearch researchers methods shouldfor studying think daily“within lifeǦon”: A paradigmatic rationale. ExperienceǡͶ͵ǦͳǤ sampling method: ǡ ǤǤǡ ǡ ǤǤǡMeasuring the qualityƬ ǡǤȋof everyday life. ʹͲͲȌǤ ǡǣ Ǥ ǡSchizophreniaǤǤȋʹͲͲȌǤ Ǥ bulletin, 33 ȋͷȌǡͳͲǦͳͲͲǤ ǡǤǤǡƬTheǡǤǤ Lancet, 383ȋʹͲͳͶȌǤ ǣ Ǧ Ǥ ȋͻͻʹͻȌǡͳǦͳͺǤ ǡǤǤǡ ǡǤǤǡǡǤǤǡ ǡǤǡƬ ǡǤǤCognitiveȋʹͲͳ TherapyȌǤ and Research, ǣǤ ͳǦͳͳǤ ǡ Ǥǡǡ Ǥǡ ǡǤǡǡ ǤǡǡǤǡǡǤǡ ǡǤǡ ǡ ǤǡǡǤǡƬǡǤȋʹͲͳ͵ȌǤ American Journal of ǣ ǡ ǡPsychiatry, 170 Ǥ ȋȌǡ͵ͶǦͶͳǤ ǡǤǡǡǤǡ ǡǤǡǡ ǤǡǡǤǡƬǡǤȋʹͲͲȌǤ ȋ ȌǣJournal of psychiatric research, 40 Ǥ ȋ͵ȌǡʹʹͳǦʹ͵ͲǤ ǡ ǤǡǡǤ Ǥǡǡ ǤǤǡǡǤǡ ǡǤǡǡǤǡǡǤǡǡ ǤǡǦ ǡ ǤǡƬ ǡǤȋʹͲͳ͵ȌǤǦǦǦ Schizophrenia ǣ bulletin, 40 Ǥ ȋʹȌǡʹͺǦʹͺǤ
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ǡ ǤǡǡǤ Ǥǡǡ ǤǤǡǡǤǡ ǡǤǡǡǤǡǡǤǡǡ ǤǡǦ ǡ ǤǡƬ ǡǤȋʹͲͳͶȌǤǦǦǦ Schizophrenia bulletinǣ Ǥ, 40 ȋʹȌǡʹͺǦʹͺǤ ǡǤǡǡǤǡǡǤǡǡ ǤǡƬActa PsychiatrǦ ǡ Ǥȋica ScandʹͲͳͳinavica,ȌǤ 123 Ǥ ȋͳȌǡʹͺǦ ͵ͷǤ ǡǤǡƬǡ ǤȋJournalʹͲͲͺȌǤ ǣ ǡǡ of postgraduate medicine, 54 Ǥ ȋͶȌǡʹͺǤ ǡǤ ǤǡǡǤǤǡǡǤ ǤǡJournal of abnormalƬ ǡ Ǥ Ǥ psychologyȋʹͲͳ, Ȍ125Ǥǣ Ǥ ȋͷȌǡʹͲǤ ǡǤǡǡǤǡEpidemiologyƬǡ ǤȋʹͲͳ and psychiatricȌǤ ǣ sciences, 25 ǫ ȋͲͶȌǡ͵ͶͻǦ͵ͷͻǤ ǡǤǡǡǤǡ ǡǤǡǡǤǡPsychologicalƬǡǤȋ ʹͲͳ͵medicineȌǤ, 43 4 ǣ ǦǤ ȋʹȌǡʹʹͷǤ ǡ ǤǡǡǤǡǡǤǤǡ ǡǤǡ ǡǤǡSocial PsychiatryƬǡǤǤȋ and PsychiatricʹͲͳ͵ȌǤ ǤEpidemiology, 48 ȋͳȌǡͷǦͳ͵Ǥ ǡǤǦǤǡƬ ǡǤȋʹͲͳ͵ȌǤ Ǥ Advances in life course research, 18 Ǥ ȋ͵ȌǡʹͳʹǦʹʹʹǤ ǡǤǤǤǡǡǤǡǡǤǡSchizophrenia Ƭbulletin. ǡǤȋ ʹͲͳȌǤ ǣ Ǧ Ǥ ǡǤǤȋʹͲͲͶȌǤ ǣMeasurement, 2 ǡǤ ȋͶȌǡʹͲͳǦʹͳͺǤ ǡǤǤǡCurrentƬ directiǡǤ Ǥȋons in psychologicalʹͲͲͻȌǤ science, 18 Ǧ Ǥ ȋʹȌǡͳͳʹǦͳͳǤ ǡǤǡƬ ‐ǡǤWorldȋʹͲͳ PsychiatryȌǤ ǣ ǡ, 15 ǡ Ǥ ȋʹȌǡͻ͵ǦͳͲʹǤ ǡ ǤǡǡǤǡǡ ǤǡƬ ǡ ǤǤȋʹͲͳ͵ȌǤ ǣ Psychosis, 5 Ǥ ȋͳȌǡ͵ǦͶǤ Ǧ ǡ ǤǡǡǤǡCurrentƬǡ Ǥ Opinionȋ inʹͲͲ͵ Psychiatry,ȌǤ 16 Ǥ ǡ͵͵Ǧ͵ͺǤ Ǧ ǡ Ǥǡ ǡǤǡǡǤǡǡ ǤǡǡǤǡƬǡ ǤȋʹͲͲͻȌǤ ǣ ǤPsychological medicine, 39 ȋͻȌǡͳͷ͵͵Ǥ
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ǡ ǤǤǡǡǤǡǡǤǤǡǡǤǡǡǤǡǡ ǤǤǡƬ ǡ ǤǤ ȋʹͲͳͺȌǤ Ǧ ǣJournal of psychiatric research, 96 Ǧ ǦǤ ǡͷǦͶǤ ǡǤǤǡǡ ǤǤǡǡ ǤǡǡǤ ǤǡǡǤǡƬ ǡ ǤǤȋʹͲͳͶȌǤ Psychopharmacology, 231 Ǥ ȋͳʹȌǡʹͶͳǦʹͶ͵͵Ǥ ǡǤ ǤǡǡǤ ǤǡƬǡǤȋPsychologicalʹͲͳͲȌǤ methods, 15 Ǥ ȋ͵ȌǡʹͲͻǤ ǡ Ǥǡǡ ǤǡǡǤǤǡƬǡǤǤȋʹͲͲͷȌǤǡ Acta ǣ ǤPsychiatrica Scandinavica, 112 ȋͷȌǡ͵͵ͲǦ͵ͷͲǤ ǡǤǤȋͳͻͺȌǤ ǣ ǡǡJournal of personality and social psychology, 52 Ǥ ȋȌǡͳͳ͵ʹǤThe British ǡ ǤJournalǦǤǡƬ of PsychiatryǦ ǡǤȋ, 187ʹͲͲͷȌǤ ǣ ǫ ȋʹȌǡͳͲͳǦͳͲʹǤ ǡ ǤǦǤǡǡǤǡǡǤǤǡSchizophreniaƬǦ ǡǤȋ bulletin, 39ʹͲͳ͵ȌǤ ǣǤ ȋȌǡͳͳͺͲǦͳͳͺǤ ǡǤǡ ǡǤǡƬǡ ǤȋʹͲͳͷȌǤ ǣ Social psychiatry and psychiatric epidemiology, 50 Ǥ ȋͶȌǡͷͻͳǦͲͳǤ ǡ Ǥǡ ǡǤǡƬ ǡǤǤȋʹͲͲȌǤ Behaviour ǣ Ǥresearch and therapy, 45 ȋ͵Ȍǡͷʹ͵Ǧͷ͵Ǥ òǡǤǡǡ Ǥǡǡ ǤǡǡǤǡƬǡǤȋʹͲͳͶȌǤ Social psychiatry and psychiatricǦ ǣǤ epidemiology, 49 ȋ͵Ȍǡ͵ͷͻǦ͵Ǥ ǡǤǡƬǡǤǤȋSchizophreniaʹͲͳʹȌǤ bulletin, 38 Ǥ ȋͶȌǡʹǦͷǤ ǡǤǡǡǤǤǡ ǡǤǡ ǡǤǤǡǡǤǡǡ ǤǡƬǦ ǡ Ǥ BrȋʹͲͳͳitishȌ ǤJournalǡ of ClinicalǦǡ Psychology, 50 ǣ Ǥ ȋʹȌǡͳͺǦͳͻͷǤ ǡǤǡǡǤǡǡǤǡƬǡ ǤȋʹͲͳͲȌǤ Schizophrenia research, 122 Ǥ ȋͳȌǡͳͻ͵ǦͳͻͺǤ
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ǡǤǡǡǤǡǡ Ǥǡ ǡǤǡǡǤǡ ǡǤǡ ǡǤǡ ǡǤǡǡǤǡƬǦ ǡ ǤȋʹͲͳͶȌǤ ǣSchizophrenia bulletin, 40 ǡǦǤ ȋʹȌǡͳʹ͵Ǧͳ͵ͲǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǡ Ǥǡǡ ǤǡƬ ǡǤǤȋʹͲͳʹȌǤ ǣǦ Schizophrenia bulletin,Ǧ ǡ Ǧ Ǧ Ǥ ͲͷͲǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬ ǡ ǤǦǤȋʹͲͳȌǤBMC Ǧpsychiatry ǣ , 16 Ǥ ȋͳȌǡͳͻͳǤ ǡǤǤǡǡǤǡǡǤǡ ǡǤǤǡǡǤǡǡǤǡǡǤǡǡǤ ǤǡƬ ǡ ǤȋʹͲͲͺȌǤ BMC psychiatry, 8 – Ǧ Ǥ 4 ȋͳȌǡͷǤ
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146807_JonasWeijers_BNW_def.indd 86 28-10-2020 15:08
Chapter Five:
Psychiatry Research (2018) Ǥ J.G.MENTALIZING Weijers1,2,*, P. Fonagy3, E. Eurelings-Bontekoe 4, F. Termorshuizen1, W. Viechtbauer2, J.P. Selten1,2. IMPAIRMENT AS A
MEDIATOR BETWEEN REPORTED CHILDHOOD ABUSE AND OUTCOME IN NONAFFECTIVE PSYCHOTIC DISORDER 5
J.G. Weijers, P. Fonagy, E.H.M. Eurelings-Bontekoe, ͳ F. Termorshuizen,ʹ ǡǤ W.V. Viechtbauer, J.-P.C.J. Selten ͵ ǡ ǡǤ ǡ ǡ ǡ ͶǡǤ ǡ ǡ ǡǡ PsychiatryǤ Research (2018) Chapter Chapter ȗǣ ǡǣǤ̷Ǥ
146807_JonasWeijers_BNW_def.indd 87 28-10-2020 15:08 Chapter Five
Abstract
Ǧ Ǥ Ǥ ǡǡ Ǥ ǦǦ Ǥ Ǥǡ Ǥ Ǥ ǡ Ǥ Ǥ ǡ Ǥ ͶͲΨ ǡ Ǥ Ǥ Keywords.
Ǣ ǢǢǢ Ǥ Introduction
Ǧ Ǧ ȋǤǡʹͲͳʹȌǤǡ ȋǡǡƬǡʹͲͳͷǢ ǡǡǡƬǡʹͲͲͷǢǡ ǡǡ ƬǡʹͲͲǢǤǡʹͲͳͷȌǡ ȋǤǡʹͲͳͷǢǤǡʹͲͳ͵ȌǤ ǡ Ǥ ǡ ȋǤǡʹͲͳͲȌǤ been defined as the capacity to understand one’s own and others’ behaviour in terms of mental ǡ ǡǡǡȋƬ ǡʹͲͳʹȌǤ Ǧ dimensions of mentalizing, such as ‘theory of mind’ (i.e. the ability to infer mental states from other’s behavior; ǡ ǡǡ ǡƬǡʹͲͲȌǡ describing their own emotional states (O’Driscoll, Laing ƬǡʹͲͳͶȌrecognizing others’ ȋ±ǡʹͲͲȌǤ
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Ǧ ǡ Ǥ ȋ ǡ ǡǡǡ Ƭ ǡʹͲͲ͵ǢƬ ǡʹͲͲͷǢǤǡʹͲͳͷȌ ȋ ǡ ƬǡͳͻͻͷǢǡ ǦǡƬǡ ͳͻͻǢƬǡͳͻͻͻǢǤǡʹͲͲͲǢǡƬǡʹͲͲͷȌǤ ǡ ǦǦ ȋ ǡ ǡƬ ǡʹͲͲͶȌ. By labelling the child’s mental stǡ ȀȋǡʹͲͳͷȌǡ ȋòǡʹͲͲͷȌǤ ǡ ǡ ȋǡʹͲͳͷȌǤǡ ǡ 5 mentalizing, because reflecting on a caregiver’s malevolent or uncaring mental states is ȋƬ ǡʹͲͳͶȌǤ Ǧ ȋ ǡʹͲͲͶȌǤ ǡone’s own intentions may contribute to the experience that one’s actions are caused or influenced by an outside force (i.e., ȌǤǡ incorrect representation of one’s own thoughts. D persecution and reference, by definition, involve the misrepresentation of another person’s Ǥ ǡǡǡ ǡ Ǥǡǡ ǡ – ed to as ‘flattened affect’ – Ǥ Lastly, failing to identify one’s own goals may contribute to avolition. ȋǡ Úǡ ǡ ǡ ƬǡͳͻͻͺǢ ǡǡƬǡʹͲͲͶǢǤǡʹͲͲȌ ȋ ǤǡʹͲͲǢ ǤǡʹͲͳͳȌǤ ǡ Ǥ
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ȋ ǡ ǡƬ ǡͳͻͻͷǢ Ƭ ǡͳͻͻȌǡ ȋ Ƭ ǡͳͻͻͻȌǤ Ǥ ǡ ȋǡǡǡƬǦ ǡǤ ʹͲͳ͵Ȍǡ ȋƬ ǡʹͲͳͲȌǡȋ ǡ ǡƬ ǡʹͲͳȌǡ ȋǡǡǡ ǡ& Myin‐Germeys, ʹͲͳͳȌǡ ȋ Ƭ ǡʹͲͲͻȌǤ Ǥ ǡ ȋ Ǥǡ ʹͲͳͳȌǤ Ǧ ȋǤǡʹͲͳ͵ȌǤ ǡȏͳȐ ǢȏʹȐ Ǣȏ͵Ȑ ǡǡ ǢȏͶȐ Ǥ Methods Participants and procedure.
Ǧ ȋ ǡǡ ǡ ȌǤ Ǥ Ǧ ǤͳͺǡǦ ǡͳͲ ǤǦ ȋǡ ƬǡͳͻͻʹȌǤ ǡ ǡ Ǥ Ǥ ȋȌ Ǥ
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Measures . The Childhood Experienceȋͳ͵Ǧ͵ǦͲǤͷȀ of Care andȌǤ Abuse ȋǢ ǡǡƬ ǡ ͳͻͻͶȌǡǦ ǡ ȋͲ–ͳȌǤ ǣ ǡ ǡ ǡ Ǥǡ ȋƬ ǡʹͲͳͶǢǡʹͲͳͷȌǤǡ Ǥ ǡ ǡǡ Ǥ Ǥ participant’s Ǥ Ȁ Ǥ Ǥ Ǧ ǣͲȋȌǡͳȋȌǡʹȋȌǡ͵ȋȌǡ ǡ Ǧ Ͷȋ ȌǤ ǦǦ ǣͲȋȌǡͳȋǣ Ȍǡʹ 5 ȋ ǣǡȌǡ͵ȋǣȌǡͶ ȋǣȌǤ Ǥ ǡͲͷʹǡ The ability to mentalize Ǥ Ǥ ȋ Ǣ ǡ ǡƬ ǡͳͻͻͷȌǡ Ǥ ǡ Ǥ ǡcharacter’sǤ ǡʹ Ǥ ǡ ͳǤ ǡͲ ǤͳͲǡ ʹͲ Ǥ ǡ The Positive andǤ Negative Syndrome Scale ȋǢǡ ǡƬǡͳͻͺȌǡ Ǧǡ ʹ Ǥ ǡ ǡ ǡ ǡǡ ǡ ǡǦ Ǥ ǡǡǡ ǡ
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ǡ ǡǤ ͶͻǤ ǡ ǤSocial dysfunctionǦȋ αǤͻͳȌǤ ȋ ȌǡǦ ȋ ǡǡ ǡǡƬǡͳͻͻͲȌǤ ȋ ǡ ǡ ȋ Ȍǡ ȋ Ȍǡ ǡ ǡ Ȍǡǡǡ ȋ ǤǡͳͻͻͲȌǤ ǡͷͻǤͳ͵ͶǤͻǤǡ Statistical analyses ǡ. Ǥ ǡ ȋǡǡ Ȍǡ Ǥ n 22 combined with Hayes’s PROCESS macro ȋ Ƭ ǡʹͲͳ͵Ȍ Ǥ Ǧ ǡ ȋ ȌǤ ͳͲͲͲͲ Ǥ ͲǤa b ȋ Ȍȋ ȌȋȌ ȋǡǡ Ȍ ȋǤǤǡ ͲȌ c’ c ȋ Ȍ ȋ Ȍ ȋͳȌǤ
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1) Positive symptoms RCA c 2) Negative symptoms
ȋ Ȍ 3) Social dysfunction
Mentalizing impairment
a b
ȋ Ȍȋ Ȍ 1) Positive symptoms
2) Negative symptoms RCA c’ 3) Social dysfunction
ȋ Ȍ
Figure 1:
ȋȌǡ ǡǡǡ
5 Ǥ Results Sample characteristics.
ǡ Ǥ Ǥn ͺǤ ǡ͵ǤͺΨȋn α͵ʹȌ ǡ͵ǤʹΨȋn αͷͷȌ ǡ͵Ǥͻ Ψȋ α͵͵Ȍ Ǥ ͳǤ
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Table 1.
ȋαͺȌǤ Mean SD
ά ȋȌ ͵ͳǤάͺǤʹ ͳͻ–ͷ ͷǤάͶǤͲ ͳ–ʹʹ ͺǤάͳͲǤ͵ Ͳ–Ͷ͵ ͷǤͷάͷǤͺ Ͳ–ͳ ͳǤʹάʹǤ Ͳ–ͳʹ ͳǤͺά͵Ǥͻ Ͳ–ͳʹ n ͲǤͳάͲǤ Ͳ– ͷ ͶǤͶ Ǧ ͷͷ ͵Ǥʹ ͳͶ ͳǤͳ ͳʹ ͳ͵Ǥͺ Ͷ ͶǤ ʹ ʹǤ͵ Main effects.
b p ȋb αͲǤͳͳǡͻͷΨ ȏͲǤͲʹǡͲǤʹͲȐǡp αͲǤͲͳͶȌ ȋ bαͲǤͳǡͻͷΨ ȏͲǤͲǡͲǤʹͺȐǡ αͲǤͲͲͶȌǡ p ȋ αͲǤͲͷǡͻͷΨ ȏǦͲǤͳͲǡͲǤʹͲȐǡb αͲǤͷͳȌǤ ǡ p ȋ αͲǤͲǡͻͷΨ ȏͲǤͲͳǡͲǤͳͳȐǡb αͲǤͲʹȌǤ p ȋ αͲǤͳͷǡͻͷΨ ȏb ǦͲǤʹͲǡͲǤͷͲȐǡ αͲǤ͵ͻͷȌǡ p ȋ αͳǤʹͲǡͻͷΨ ȏͲǤͺʹǡͳǤͷͺȐǡ δͲǤͲͲͳȌǡ ǡ b p ȋ αͲǤͷͷǡͻͷΨ ȏǦͲǤͲͷǡͳǤͳͶȐǡ αͲǤͲ͵ȌǤ ǤMediation. ǡ– ǡǡ– Ǥ b ǡp ͳȋ αͲǤͲǡͻͷΨ ȏͲǤͲͲʹǡͲǤͳȐǡ αͲǤͲ͵ͻȌǡ Ǥ b p ͳȋ αͲǤͳǡͻͷΨ ȏͲǤͲǡͲǤʹͺȐǡ αͲǤͲͲͶȌ
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b out 40% when mentalizing impairmentp was accounted for, path c’ in figure 1 ȋ αͲǤͳͲǡͻͷΨ ȏͲǤͲͲ͵ǡͲǤʹͲȐǡSensitivity analysis. αͲǤͲͶ͵Ȍǡ Ǥ ǡ R p ʹ ȋR p αͲǤͳͺͲǡ δ ʹ ǤͲͲͳȌǡȋ αͲǤͲͻͷǡ αǤͲͲͶȌǤ R p ʹ ȋR p αͲǤͲͺʹǡ αͲǤͲʹȌǡ ʹ ȋ αͲǤͲͷǡ αǤͲʹȌǤ Ǥ ǡ ǡ ǡǤ ǡ Ǥ ǡ ȋ ƬPreacher, 2010). “Instantaneous indirect effects” were generated at different levels of reported childhood abuse (one standard 5 Ȍ Ƭ ȋʹͲͳͲȌǤ ǡthe subgroup reporting relatively high childhood abuse (CECA ≥ 19), there ȋR pθαͲǤͲͻǡͻͷΨ ȏͲǤͲͳǡ ʹ ͲǤʹʹȐȌǤ ͶͲΨȋ αͲǤ͵ͻͶǡ δǤͲͲͳȌ Ǥ Discussion Discussion of the results.
Ǧ ǤǦ Ǥ ǡ Ǥǡǡ ǡ Ǥǡ ǡ ͶͲΨ Ǥǡ ǡ ǡ Ǥ
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Comparison to previous findings.
ȋ ǡǡ ǡƬǡʹͲͲͷǢǡǡǡ ƬǡʹͲͲǢǡ ǡƬǡʹͲͳͷǢǤǡʹͲͳͷȌ ȋƬ ǡʹͲͳͶǢǡʹͲͳͷȌǤ ǡ ǡ ȋ Ƭ ǡͳͻͻͻǢǤǡͳͻͻͺǢ ǤǡͳͻͻͺǢ ǤǡʹͲͲͶǢǤǡ ʹͲͲȌǤ ǡ rather a tendency to excessively do so, or to ‘hypermentalize’ȋǦƬǡʹͲͲͲǢ ǤǡʹͲͳȌǤ Ǧǡ ȋǤǡʹͲͲͲǢǡʹͲͲ͵Ȍǡ ȋ Ƭ ǡͳͻͻͻȌǤ ǡ ǡȋ ǡ ǡƬ ǡʹͲͳȌǤ ǦȋǤǤǤǡʹͲͲͷȌǡ ȋǤǡʹͲͳ͵ȌǤ ǡ ǡ ȋʹͲͳͶȌǤ ǡ ȋǤǡʹͲͲͶǢǤǡʹͲͳ͵Ǣ ǤǡʹͲͳͷȌǤ Ǥ ȋ ǤǡʹͲͲǢǤǡʹͲͳ͵ȌǡȋǤǡʹͲͳ͵ǢǤǡʹͲͳͷȌ Ǥ ǡǡ ͷǤ ͷ Ǣ ǡ ǡȋ ǡǡƬ ǡͳͻͻͺȌǤ ǡ ǡ Ǥǡ Ǥ ǡǤȋʹͲͳͶȌ ǡǤȋʹͲͲͶȌ Ǥ
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ǡ ǡ ǡ Ǥ ǡ ǡȋʹͲͲȌǤClinical implications. Ǧ Ǥ ǡ Ǧ Ǥ ǡȋǡ Ƭ ǡʹͲͳͶǢǤǡʹͲͳȌ ȋǤǡʹͲͳͶȌ Ǥǡ ȋ±ǤǡʹͲͳȌǤ ǡ 5 ǡ ȋƬLimitationsCantor‐Graae, and 2014) conclusionsǤ . ǡǤ ǡ Ǥ ǡ ȋƬ ǡʹͲͳ͵ȌǤ ǡ ǡ ǡȋǡǡǡǡǡƬǡʹͲͲͷ ȌǤ ǡ ȋǤǡʹͲͳͲȌǤ ǡ ǡ ǦǤ ǡǡ ǡ ȋǤǡʹͲͳͶȌǤ ǡ ȋǡƬ ǡʹͲͳͳȌǤ Ǥ ǡ Ǥ ǡǡ ǡǦ Ǥ
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ǡ – ǡ – ǡ–ȋ ƬǡʹͲͳʹȌǤ ǡ ȋ±ǤǡʹͲͳȌǤ ǡ ǦȋǤǤ ǦǢǤǤǤǡʹͲͲȌǤ Ǥ ǣ Ǧ ȋ ǡ ʹͲͳͶȌ ȋ ǤǡʹͲͲͶȌǤ Ǧ ǡ Ǥ ǡ Ǥ ǡ Ǧ Ǥ Funding
ǡ ǡ ǦǦ Ǥ ȋ Ȍ ȋ Ȍ ȋǤ Ǧ ǦͲͷͳͶǦͳͲͳͷȌǤȋȌ ǡ Ǥ
Contributors
Ǥ Ǥ ǡ Ǥ Abbreviations.
ǣ Ǣ ǣ Ǣ ǣ Ǣǣ
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Disclosure of interest
Ǥ Acknowledgements
References Psychological medicine, 30
ǦǡǤǡƬǡǤǤȋʹͲͲͲȌǤǤ ȋ͵Ȍǡ͵ͷǦ͵ͺǤ ǡ Ǥǡǡ ǤǡƬǡǤȋʹͲͲȌǤ ǣSchizophrenia research, 85 ǫ ȋͳȌǡͳͶʹǦͳͷͲǤ ǡǤǡ ǡǤǡǡǤǡ ǦǡǤǡǡǤǡƬǡǤȋʹͲͳͷȌǤ . Psychologicalǣ medicine, 45 ȋͳ͵ȌǡʹʹǦʹ͵Ǥ ǡǤǤǡ ǡǤǡƬǡǤȋͳͻͻʹȌǤ Archives ȋ Ȍǣ of general psychiatry, 49 Ǥ HandbookȋͺȌǡͳͷ ofǦ mentalizingʹ͵Ǥ in mental health practice. 5 ǡǤǤǡƬ ǡǤȋʹͲͳʹȌǤ ǡǣ ǡ Ǥ ǡǤǤǡǡǤǡǡ Ǥǡ ǡǤǡǡǤǡ ǡǤǡƬǡ ǤȋʹͲͳͶȌǤ ǣ Social Psychiatry and Psychiatric Epidemiology, 49 Ǥ ȋȌǡͳͲͳͳ–ͳͲʹʹǤ ǡǤǡǡ ǤǤǡƬ ǡǤǤȋͳͻͻͶ. JournalȌǤ ȋȌǣ of Child Psychology and Psychiatry, 35 ȋͺȌǡ ͳͶͳͻǦͳͶ͵ͷǤ ǡǤǡǡ Ǥǡ ǡǤǡǡǤǡƬǡǤȋͳͻͻͲȌǤ Ǥ The British Journal of ǤPsychiatry, 157 ȋȌǡͺͷ͵ǦͺͷͻǤ ǡǤǡǡǤǡInternationalƬ ǡǤȋ Clinicalͳͻͻͺ PsychopharmacologyȌǤ ǣ , 13 Ǧ Ǥ ǡ͵ͳǦͶͲǤ ǡǤǦǤǡǡǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǡǤǡǡ Ǥǡ ǡǤǡƬǡǤȋʹͲͳͶȌǤ Schizophrenia bulletin, 40 Ǥ ȋȌǡͳ͵ͷǦͳ͵ͷǤ ǡǤǤǡ ǡǤ ǤǡǡǤǤǡǡǤ ǤǡƬ ǡǤȋʹͲͳͶȌǤǦ ǣ Ǧ
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The Israeli
Journal of Psychiatry and Related Sciences, 51 Ǥ ȋͳȌǡͳǦʹͶǤ Schizophrenia òǡǤȋbulletinʹͲͲͷ, Ȍ. “Theory of mind” in schizophrenia: a review of the literature. ͵ͳȋͳȌǡʹͳǦͶʹǤ ǡ Ǥǡ̵ǡǤǡǡǤǡǡǤǡǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͲȌǤ ǣSchizophrenia research, 89 ǫ ȋͳȌǡʹͺǦʹͻʹǤ ǡǤǤǡ ǦǡǤǡƬǡǤǤȋͳͻͻȌǤ ǣ ǤEmotional development in atypical children ǤƬǤǤȋǤȌǡ ȋǤʹͲ͵Ǧ ʹʹͷȌǤ ǡ ǣ Ǥ ǡǤ ǤȋʹͲͲ͵ȌǤThe social brain—Evolution and pathology. ǣ Ǥ ǡǣ ƬǤ ǡǤǡƬ ǡǤȋʹͲͳͶȌǤ ǡPersonality and mental health, 8 Ǥ ȋͳȌǡͷʹǦǤ ǡǤǡ ǡ ǤǤǡǡǤǡǡǤǤǡDevelopment and psychopathology,Ƭ ǡ ǤȋʹͲͲ͵ 15ȌǤ Ǥ ȋͶȌǡͳͲǦͳͲͻͳǤ ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǡ§ǡǤǡǡǤǤǡǦ ǡǤǡǡǤǡƬ ǡǤȋʹͲͳȌǤ Psychological medicine, 46Ǧ ǦǦ – Ǥ ȋͳȌǡ ͺǦͳͲͳǤ ǡǤǡ ǡ ǤǡƬ ǡǤǤȋͳͻͻͷȌǤ ǡ Schizophrenia inference:research, 17 investigating “theory of mind” in people with schizophrenia. ȋͳȌǡͷǦͳ͵Ǥ ǡǤǤǡǡǤǤǡƬǡǤǤSchizophreniaȋʹͲͲȌ bulletinǤ , 32 ǣǤ ȋͳȌǡͶͶǦ͵Ǥ ǡǤǤǡǡǤǤǡǡ ǤǤǡǡǤǤǡǡǤǤǡƬǡ ǤȋʹͲͳͲȌǤ Ͷ͵ǤChild abuse & neglect, 34 ȋͳͳȌǡͺͳ͵ǦͺʹʹǤ ±ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡ ǡǤǡƬǡ FrontiersǤǤȋʹͲͳ inȌǤ ǡǡ Ǥ Human Neuroscience, 10 ȋͶͲȌǡͳǦʹʹǤ ǡ Ǥǡ ÚǡǤǡ ǡǤǡ ǡǤǡPsychological medicine, 28 ƬǡǤǤȋͳͻͻͺȌǤ Ǥ ȋʹȌǡ͵ͻǦͶͲͷǤ
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ǡǤǡǡǤǡƬǡǤȋʹͲͲͷȌǤ ǣChild maltreatment, Ǥ 10 ȋ͵Ȍǡʹͻ͵Ǧ͵ͲͶǤ ǡǤǡǡǤǡǡǤǡ ǡǤǡǡǤǡƬǡǤȋʹͲͳͷȌǤ ǣBritish Journal of Developmental ǤPsychology, 33 ȋʹȌǡʹͲ͵ǦʹͳǤ ǡǤǦǤ ǤǡǡǤǡƬ ǤȋʹͲͳͳȌǤ Schizophrenia bulletin, 35 ǣ ǫ ǡͷ͵ǦͷͺͺǤ ǡǤǡ ǡ ǤǡƬ ǡǤǤȋʹͲͲͶȌǤ ǡ Ǥǡǣ ǡǤǡƬǡǤȋʹͲͳʹȌǤ From the Couch to the Ǥ ǣLab: Trends in Psychodynamic Neuroscience The cognitive neuropsychology ofǤ schizophrenia.ǡǣǤ ǡǤǤȋʹͲͳͶȌǤ ǡǣ ǡǤ ǡǤǤǡPsychologicalƬ ǡǤȋ medicineͳͻͻ, 26Ȍ. Exploring ‘theory of mind’ Ǥ 5 ȋ͵ȌǡͷʹͳǦͷ͵ͲǤ ǡǤǤǡƬ ǡǤȋͳͻͻͻBritishȌǤ ǣ journal of clinical psychology, 38 Ǥ ȋʹȌǡͳͳ͵ǦͳͷͶǤ ǡǤǤǡƬ ǡǤǤȋʹͲͲͻȌǤ Schizophrenia Bulletin,ǡ 35 ǡ Ǥ ȋͶȌǡ ͻͺ–ͺͲǤ ǡǤǤǡǡ Ǥ ǤǡƬǡǤǤȋʹͲͲͶȌǤ ǣThe Journal of nervous and mental ǡǡ Ǥ disease, 192 ȋͳȌǡͳʹǦͳͺǤ ǡǤ ǤǡƬ ǡǤ ǤȋʹͲͳͲȌǤ Multivariate behavioral research, 45 Ǥ ȋͶȌǡʹǦͲǤ ǡǤ ǤǡƬ ǡǤ ǤȋʹͲͳ͵ȌǤ ǣ Structural equation modeling: A Ǥ ǣsecond course ǡʹͳǦʹͶǤ ǡǤǤǡ ǡǤǡ ǡƬǤǤSchizophreniaȋʹͲͳȌǤ ǣ bulletin, 43 Ǥ ȋ͵ȌǡͷͷǦͷͷǤ ǡǤǤǡ ǡǤǡƬǡǤǤȋ. Schizophreniaͳͻͺ bulletinȌǤ ȋ, 13 Ȍ ȋʹȌǡʹͳǦʹǤ
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ǡǤȋʹͲͳͷȌǤǣ Personality Disorders: Theory, Research, and Treatment, 6 Ǥ ȋͶȌǡ͵ͷǦ͵ͷǤ ǡǤǡǡǤǡǡǤǡǡ Ǥǡ& Myin‐Germeys,Acta Psychiatrica I. (Scandinavica,ʹͲͳͳȌǤ 123 Ǥ ȋͳȌǡʹͺǦ ͵ͷǤ ǡǤǤǡǡǤǡƬ ǡǤǤȋʹͲͳȌǤ ǣ European Psychiatry, 42 Ǥ ǡͳͳͳǦͳͳͻǤ ǡǤǡǡǤǡEpidemiologyƬǡ ǤȋʹͲͳͷ and psychiatricȌǤ ǣ sciences, 25 ǫ ǡ͵ͶͻǦ͵ͷͻǤ ǡǤ ǤǡǡǤǤǡ ǡǤǤǡƬǡǤǤȋʹͲͲͶȌǤ Journal of traumatic stress, 17 Ǥ ȋͷȌǡͶ͵ͷǦͶ͵ͺǤ ǡǤǡ ǡǤǡ ǡǤǡƬ ǡǤȋʹͲͳͳȌǤ ǡPsychology and Psychotherapy:mentalization, and Theory, their Research correlates and in Practice, a first‐episode 84 psychosis sample. ȋͳȌǡͶʹǦͷǤ ǡǤǤǡǡǤǤǡƬ ǡǤǤȋʹͲͳͳȌǤ Ǧ Multivariate ǣ ǤBehavioral Research, 46 ȋͷȌǡͺͳǦͺͶͳǤ ǡǤ Ǥǡǡ Ǥǡ ǡ ǤǤǡǡǤǤǡ. Cognitive NeuropsychiatryƬǡǤ, 3 ǤȋͳͻͻͺȌǤ ȋʹȌǡͳʹǦͳ͵ͺǤ ǡǤǡǡǤǤǡ ǡǤǤǡ ǡǤǡǡǤǡƬǡǤǤȋʹͲͳ͵ȌǤ Frontiers in human neuroscience, 7 Ǧ Ǥ ȋͺͳȌǡͳǦͳʹǤ ̵ ǡǤǡǡ ǤǡƬǡǤȋʹͲͳͶȌǤǡClinical psychology ǡreview, 34 ǦǤ ȋȌǡͶͺʹǦͶͻͷǤ ǡǤǤǡ ǡǤǡ ǡǤǡƬǡǤȋʹͲͲͲȌǤ Developmental psychology, ǣ 36 Ǥ ȋͷȌǡͻǤ ǡǤǡƬ ǡǤǤȋʹͲͲͷȌǤǡ ǡ JournalǦ ǣ of Developmental & Behavioral Pediatrics, 26 Ǥ ȋʹȌǡͳͳʹǦͳʹʹǤ ǡ Ǥǡǡ ǤǡǡǤǤǡƬǡǤǤȋʹͲͲͷȌǤǡ Acta ǣ ǤPsychiatrica Scandinavica, 112 ȋͷȌǡ͵͵ͲǦ͵ͷͲǤ
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ǡ ǤǡƬ ǡǤȋʹͲͳͲȌǤ Telling stories Ǥ ǡͷͳǦͻͶǤ ǡǤǡƬǡǤȋSchizophreniaʹͲͲͶȌǤǡ research, 68 Ǧ Ǥ ȋʹȌǡͳͶͻǦͳͷͺǤ ǡ ǤǤǡ ǡǤǡƬǡ ǤǤȋͳͻͻͷȌǤ Development and psychopathology, 7 Ǥ ȋͶȌǡͷͻͳǦͲͻǤ ǡǤǤǡǡǤǤǡǡǤǡƬǡǤǤȋʹͲͲͷȌǤ ǣ ǡSchizophrenia research, 76 ǡ Ǥ ȋʹȌǡʹ͵ǦʹͺǤ ǡ ǤǤǡǡǤǡǡǤǤǡSchizophreniaƬǦ ǡǤȋ bulletin, 39ʹͲͳ͵ȌǤ ǣǤ ȋȌǡͳͳͺͲǦͳͳͺǤ ǡ ǤǤǡ& Cantor‐Graae,Acta Psychiatrica E. (ʹͲͳͶ ScandinavicaȌǤ , 129 Ǥ ȋȌǡͶͻǦͶͺͲǤ ǡǤ ǤǡǡǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡǡǤǤǡƬ ǡǤ Ǥ ȋʹͲͲȌǤ ǣSchizophrenia research, 90 5 Ǥ ȋͳȌǡ͵ͳǦ͵ʹͶǤ ǡǤǤǡƬǡ ǤȋͳͻͻͻȌǤǣ Journal of Clinical Child Psychology, 28 Ǧ Ǥ ȋ͵ȌǡͶͲǦͶͳǤ ǡ ǤǡǡǤǡǡǤǡ ǡ ǤǦǤǡƬǡ ǤȋʹͲͲȌǤ ǣThe British Journal of Psychiatry, 188 Ǥ ȋȌǡͷʹǦͷ͵͵Ǥ ǡǤǡ ǡǤǡǡǤǡ ǡ ǤǡThe British JournalƬ ofǡ Ǥȋ Psychiatry, 191 ʹͲͲȌǤ Ǥ ȋͳȌǡͷǦͳ͵Ǥ ǡ Ǥ ǤǡÞ ǡǤǡ ǡǤǤǡ ǡ Ǥǡ ǡ ǤǤǡǡ ǤǡǡǤǡƬ ǡǤǤȋʹͲͳ͵ȌǤ Schizophrenia bulletin, 40 Ǧ Ǥ ǡͳͶͻͳǦͳͶͻͺǤ ǡǤǡǡǤǤSchizophreniaȋʹͲͳʹȌǤ bulletin, 38 Ǥ ȋͶȌǡʹǦͷǤ ǡǤǡǡǤǡ ǡǤǡǡǤǡ¡ǡǤǡ ǡ ǤǡƬǡǤǤ ȋʹͲͳ͵ȌǤEarl y intervention in psychiatry, 7 Ǥ ȋͳȌǡͷͳǦ ͷǤ Dialogues in clinical ±ǡ Ǥneuroscience,ȋʹͲͲȌǤ Ǥ 8 ȋͳȌǡͷͻǦͲǤ
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ǡǤǡǡǤǡ ǡǤǡǡǤǡǡǤǡǡǤǡǡ Ǥǡ ǡǤǡǡǤǡƬǡǤȋʹͲͳͷȌǤ ǤPsychological medicine, 45 ȋȌǡͳ͵͵Ǧͳ͵Ǥ ǡǤ Ǥǡ ǡǤǡ ǡǤǡǡǤǡǡǤ ǤǡǡǤǡƬ ǡ Ǥ ǤǤȋʹͲͳͶȌǤǦ BMC psychiatry, 14 ǣ Ǧ Ǥ ȋͳȌǡͳͶNatureǦʹǤ , ǡ Ǥǡǡ Ǥǡ468 ƬǡǤǤ ǤȋʹͲͳͲȌǤ Ǥ ȋ͵ʹͳȌǡʹͲ͵ǦʹͳʹǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǡ Ǥǡǡ ǤǡƬ ǡǤǤȋʹͲͳʹȌǤ ǣǦ Schizophrenia bulletinǦ ǡ , 38 Ǧ Ǧ Ǥ ȋͶȌǡͳǦͳǤ ǡǤǡò ǡǤǡǡǤǡƬǡǤǤȋʹͲͲͶȌǤ ǫPsychiatry research, 128 ȋʹȌǡͳͷͷǦͳͷǤ ǡ ǤǡǡǤǤǡƬǡǤ ǤȋʹͲͲͲCognitiveȌ. “Theory Neuropsychiatry, of mind”, persecutory 5 Ǥ ȋ͵ȌǡͳͳǦͳͶǤ ǡǤǡǡǤǤǡǡǤǤǡƬǡǤǤȋʹͲͲͷȌǤ ǡǡǡJournal of ǣ ǤCounseling Psychology, 52 ȋͶȌǡͷͻͳǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬ ǡ ǤǦǤȋʹͲͳȌǤBMC Ǧpsychiatry, ǣ 16 Ǥ ȋͳȌǡͳͻͳǤ
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PART III:
MENTALIZATION
BASED TREATMENT
FOR PSYCHOTIC
DISORDER
III Part
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Chapter Six:
Ǧ ǣ BMC Psychiatry (2016) Ǥ JonasMENTALIZATION- Weijers1, 2,*, Coriene ten Kate1, Elisabeth Eurelings-Bontekoe3, Wolfgang Viechtbauer2, Rutger Rampaart1, Anthony Bateman4,5 and Jean-Paul Selten1,2 BASED TREATMENT
FOR PSYCHOTIC DISORDER: PROTOCOL OF A RANDOMIZED CONTROLLED TRIAL 6
ͳ ǡǤ ʹ J.G. Weijers, C. ten Kate, E.H.M. Eurelings-Bontekoe,ǡ ǡǤ ͵ W.V. ǡ ǡǡǡ Viechtbauer, L.J.A. Rampaart, Ǥ ͶA.W. Bateman, J.-P.C.J. Selten ǡ ǡǤ ͷ ǡǡ ȗ ǣǤ̷Ǥ BMC Psychiatry (2016) Chapter Chapter
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Abstract
Background: Ǧ ǤǡǦ ǡ ǡ Ǥ ǡ Ǥ ǡ ǡ ǡ Methods/design:ǡǡ Ǥ Ǧ Ǥ ͳͺ Ǧ Ǥ ǡǡͳͺͷͷ Ǧ Ǥ ǡ ǡ Ǥ ʹʹǤǦ Ͳͳͷ Ǥǡ Discussion: Ǥ Ǧ ǡ Trial registration:Ǥ Keywords: ǣͶͶǤͲͺǦͳͻǦʹͲͳͶǤ ǡǡ ǡ ǡ ǡ ǡ Background and rationale
Ǧ ȋȌ ǡ ǡ ȋǡ ƬǡʹͲͲͺȌǤ Ǥ ȋ ǡǡƬ ǡʹͲͲʹȌǡ ǦȋǡƬ ǡʹͲͲȌǤ ȋǡǡ ǡƬǡʹͲͲͻȌȋ ǡǡƬǡͳͻͻʹȌǤ ǡǡ Ǥ –ed as “the ability to construct ǡsocial behavior”
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ȋǡʹͲͲͳȌ ȋòǡʹͲͲͷȌǤ ȋǡǡǡ ƬǡʹͲͳͲȌǡ ȋƬǡʹͲͲͻȌǡother person’s perspective ȋǡ ǡƬ ǡ ʹͲͲȌ ȋǡǡǡƬǡʹͲͲȌǤ ǡ Ȁ ȋƬǡʹͲͲǢƬǡʹͲͲͻǢǤǡʹͲͲȌǡ Ǥǡǡ ȋƬǡʹͲͲͻǢ ǤǡʹͲͲǢ Ƭ×ǡʹͲͳ͵ȌǤ Ǧ ȋȌ ȋǢƬ ǡʹͲͲȌǤ ȋǤǡʹͲͲǢǤǡʹͲͳʹȌǡ Ǥǡ ȋǤǡʹͲͳͶȌ– ȋƬ ǡ ʹͲͳͶȌ– ȋǡ Ƭǡ ʹͲͲȌǤǦ 6 e process called ‘mentalizing’. ȋʹͲͲʹȌ “the process by whi intentional mental states”. ǣȋȌ ǢȋȌ ǢȋȌ ǢȋȌ ǢȋȌ ǡ ȋƬ ǡʹͲͲȌǤ ǡ ȋƬ ǡͳͻͻͻȌǤ ǡ ȋǤǤǡͳͻͺȌ Ǥ ǡ Ǥ ǡ ǡ ǡǡ ȋǡǡ ǡƬǡʹͲͲȌǤ ǡͳΨ
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ȋǡ ǡǡ ǡƬǡʹͲͳͲȌǤǡ ǡ or to “hypermentalize”ȋǤǡʹͲͳͶǢǤǡʹͲͳͳǢǦƬǡʹͲͲͲȌǤ ǡ ǦǦ ȋ ƬǡͳͻͻȌǤǡ ȋǤʹͲͳʹȌǤ ǡȋƬ ǡʹͲͳͶǢǡʹͲͲͻȌǡ Ǥ Research aims and hypotheses Primary research aim.
Ǧ ȋȌǦ Ǥ ȋȌǤ Ǧ ǦǤSecondary research aims. Ǥ ȋʹͲͲȌ, MBT’s mechanism change is improving patients’ mentalizing capacities. ǡ ǡ Ǥ ǡǡ ȋͳͻͻͻȌ Ǥ Ǥ ǡ Ǥǡ ȋ ǤǡʹͲͳͶȌǡ Ǥ ǡ ȋʹͲͲȌ ǡǤǤǡ ǡǤǡ Ǥ patients’ ǡ ǡ ȋǦ ƬǡʹͲͲȌǤǡ ǡ ȋ ǡ Ƭ ǡͳͻͻͷǢ ǡƬǡʹͲͲͶǢǤǡ ʹͲͲȌǤ
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Covariates.
Ǥ ǡ ǡ ǡ ȋǡƬ ǡͳͻͻȌǤ ǡ ȋȌ ȋǤǡʹͲͳʹȌ ȋǦǡǡƬǡ ʹͲͲͻȌǤ ȋȌǡ impulse inhibition or ‘control’: ȋ ǡǦ ȌǢȋ ǡ ȌǢ ȋ ǡ ȌǢ ȋ ǡ ȌǢ ȋ ǡ ȌǤǡ ȋǡǡǡ ƬǡʹͲͳ͵Ȍǡ ȋ ǡͳͻͻȌǤ ȋȌ ǡ “somatization”. ȋȌ Ǥ ǡ ǡ Ǥ ǡ 6 ǡ Ǥǡ Ǥ ǡǡ Ǣǡ ǡ Ǥ Methods/design
Trial design/setting . Ǧǡ Ǥ ȋȌǤ Ǧ Ǧ ȋǤǤǡǡ ȌǤ ǡ Ǥ ȋͲȌȋʹȌ ǤParticipants. Ǥ ȋǦ ȋǡ ʹͲͲͲȌȌǣ ǡ ǡ ȋʹͻͷǤȌǡ ȋʹͻǤͳȌǡ ȋʹͻͺǤͺȌǡ ȋʹͻͺǤͻȌǤͺͲ Ǥ
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ǣ –Ǥ –ͳͲǤ –ͳͺͷͷǤ ǣ – Ȁ Ǥ – Ǥ – Ǥ Ǥ Ǥ Sample size calculation.
Ǥ ȋƬ ǡ d ͳͻͻͻȌ ȋd α ͲǤͻͷǢͻͷΨǢ ǣͲǤͷͻ–ͳǤ͵ͲȌ ȋ αͲǤʹǢͻͷΨ ͲǤ͵–ͳǤͲȌǤ ȋ Ȍ–(d d – αͳǤȌ ȋ αͳǤͷȌ ȋƬ ǡʹͲͲͻȌǤǡd cognition (i.e., a Cohen’s ͲǤȌǤ ǡ ȗ ȋ ǡ ǤǡǡǤǡ ǡǤǡƬǡǤǡʹͲͲͻȌǤ ǤͺͲǦȋ Ǥ αǤͲͷȌǡͺ Ǥ ǡ ȋ ǦȌ –Ǧ –ǤȋƬǡ ʹͲͳ͵Ȍ ǣ Ǧ αȋͳǦρ2)* ; where ρ is the testǦ Ǥ Ǧ half years is ρ = .40 ȋƬǡʹͲͲͲȌǤǣȋͳǦ0.42)*68 ≈ 58 ͺͲΨ Ǥ ǦǤ ǡ ǡǦͳͳͲΨǤ ǡǦ Ǥǡǡ ͶͲȋȌΪͶͲȋȌαͺͲ
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ǤʹͷΨȋǤǤǡʹͲȌǡͲ Ǥ ǡ ͶͲ Ǥ Procedure
ǡ ǡ Ǥ ǡ Ǥ Ȁ Ǥ ǡ Ǥǡ Ǥ Measurements and instruments. Ǥ ʹǤ Ǥ ǡ ͻȋȌǡͳͺȋ ȌǡʹͶȋȌǤͳ Diagnosis. Ǥ Ǧ ȋǡʹͲͲͲȌ 6 Ǥ ǡ ȋ ȌǤ ǡǡ ǡ Ǥ ǡSocial functioningǦ. ȋǡ ƬǡͳͻͻʹȌǤ ȋ ȌǡǦǤ ǡǡǡ ȋ ǡǡ ǡƬǡͳͻͻͲȌǤ Ǥǣ ǡ ǡ ȋ Ȍǡ ȋ Ȍǡ ǡ ǡSocial cognitive or ‘mentalizing’Ǥ capacity . ǡ ȋǤǡʹͲͳͶȌǤ ǡ ǣ ȋȌȋ ȌǤȋǡͳͻͶ͵Ȍǡ ȋǢǡͳͻͻͳȌǡ
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ǣ ǡ ǡ Ǧ ǡ Ǥ ͷǦ ǡ Ǥ Ǥ Ǥǡǡ ȋǡʹͲͲͶǢ ǡ Ƭ ǡʹͲͲͳȌǤ ȋǡ ǡ ƬǡʹͲͳʹȌǡ The HT ǡ Ǥ ȋ ǡ Ƭ ǡͳͻͻͷȌ intentions from others, or ‘Theory of Mind’ (ToM). Ǥ ǡ Ǥ ǡ ͳǤ ǡͲ Ǥ Ǥ ȋǡǡ Ƭ ǡʹͲͳͷȌǦǡ ǡ ǡ Social stress reactivity. Ǥ with an electronic diary using the ‘ExperienceSampling Method’ (ESM; MyinǦ Ǥǡ ʹͲͲȌǤǦ Ǥ ǡ Ǥ ǡȋȌ Ǥ Ǥǡ Ȁ Ǥ items such as: “I would rather ” and “I like the present company” (reverse coded). items “anxious”, “lonely”, “insecure”, “”, “down”, “guilty”, and“gloomy”. Positive affect will “happy”, “satisfied”, “cheerful”, “relaxed”, and “enthusiastic”. Ǧ ǤQuality of life. ȋǢǡ ǡƬǡͳͻͻͻȌǡ Ǥ ͳǦǡǦ ǦǤ
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Psychotic symptom severity.
ȋȌȋǡ ƬǤͳͻͺȌȋ Ȍǡȋ Ȍǡ ȋ ʹȌǡȋ ͶȌǤ͵ͲǦǡǦǦ Ǥ ȋǡƬ ǡʹͲͲͲȌǤ ǡ Ǥ used: ‘I feel suspicious’, ‘I am afraid of losing control’, ‘ that others don’t like me’, ‘I feel that others want tohurt me’, ‘My thoughts are influenced by other people’, ‘I unreal’, and ‘I hear voices’.Ǥȋ ͳʹȌ Substance abuse. Ǥ Ǥ ǡ ǣȋͳȌ ǡȋʹȌ ǡȋ͵Ȍ ǡȋͶȌ ǡȋͷȌ ǡ ȋȌǡPersonalityȋ organization/somatizationȌǤ of psychopathology. ȋ ǢƬǡͳͻͺͷȌǡͺ͵Ǧ ǦǤ ͷ ǣǡ 6 ǡǡǡǤ ȋǦƬǡʹͲͲǢǦǡǡ ǡƬǡʹͲͳͲǢǦǡǡƬǡ ʹͲͳͲǢǦǡǡǡƬǡʹͲͳʹǢǦǡ ǡǡƬǡʹͲͳͶȌǡȋȌ ǣ ǡǡ ǡ Ǥ, the DSFM “Somatization” subscale (20 ȌǤ ǡ ǡ ǡǤ ȋǦǤǡʹͲͳͶȌ ǤChildhood trauma. ȋǢ ǡ Ƭ ǡͳͻͻͶȌǦ Ǧ Ǥ ȋ ǡȌǡ ǡ ǡ Drug treatment: Ǥ patient’s medical record is consulted to Ͳǡͳǡʹǡ͵Ǥ
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Adherence to the prescribed medication
ȋǢǡ ǡAdherence to the MBT-model. ƬͳͻͺȌǤ ȋǡ ǤǡʹͲͳ͵ȌǡǤͳ ǤDuration of illness . General demographics. ǡ Ǥ ȋ Ȍ Ǥ ǡ Ǧ ǡ ǡ Ǥ
Treatment. TAU.
‘F’ (FACT) model. FACT teams consist ǡǡ ǡ Ǥ ǡ Ǧǡ ǡ ȋȌǤ ʹͲ ȋ ǡǡƬǡʹͲͲͷǢ ǡƬǡʹͲͳ͵ȌǤ ǡ ǡ Ǥ ǡ Ǥ
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ǡǡ ǡ Ǥ ͵Ͳʹǡͳ͵Ͳ ǡͳͺǤ ͵ͲȋͳͷȌǤ registeringMBTp patients’. Ǥ Ǥǡ ǡȋƬ ǡʹͲͲȌǤ MBT is characterized by the ‘not knowing stance’ Ǥ Ǥ being ‘keptin mind’ by ǡInterventions. Ǥ ǡ Ǥ ǦǡǤǡ Ǥ of the patient’s Ǥ the patient’sǤ 6 or rewinds the patient’s narrative to Ǥ Ǥ ǡ ǡǤǡ ‘mentalized affectivity’, which is the activity of ǡ Ǥ Ǥ ȋ ȌǦ Ǥǡ Ǥ ǡ Ǥǡ ǤDuration and dose. ǡǡ ǣͳͺǤ ǡ Ǥ ǡǡ ǡȋƬǡʹͲͲ͵ȌǤ ǡǡ ͳǦǡ
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ǦǤ ǦͳͲΨ ǤPsycho -education. Ǧ ǡ ǡ IndividualǤ therapy . Ǥ Ǥ ǡ ǣ ǡ ǡ Ȁǡ ǡ Group Ǥ therapy. ǡ Ǧ Ǥ Ǥ Therapists. Ǧ Ǥ Ǥ ȋ ǡ Ȍ Ǥ ͳǡ Ǥ Statistical analysis Main effect.
Ǥ ǡ Ǧ ǡ ǡ Ǥ ǡǡ ǡ ǡ ǡ ǦǤ ȋ ǡǡ ǡǡǡ ȌǤ Ǧǡ Ǧ ȋǤǡʹͲͲȌǤ ǡ ǡ Ǥ ȋʹͲͲͻȌǡwill therefore be conducted on the basis of ‘intention ’ (ITT), meaning that they will include all ǡ
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Ǥ ȋ Ǣ ǡͳͻͻͻȌǤ Ǥ Ǧǡ ǤȋǡƬǡʹͲͲ͵Ȍ ǡ ǡǡǡǡǡ Ǥǡ ǡ Ǥǡ ǡ Ǥ ǡͷ ȋȌ ǡ ȋ Ƭ ǡʹͲͳ͵MediationȌǤ . Ǥ ǡ Ǧȋ Ƭ ǡʹͲͲͶȌǤ ǡǣ ǡ ǡ Ǧǡ ȋ ǤͳȌǤ 6
Multilevel analysis. Ǥ Ǥ ǡǤ ȋǤǤǡ Ȍ ǤǦ ȋʹͲͲͳȌǡ Ǧ ǡ ǡ ǡ
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Ǥ ǡ Ǥ Discussion
ǡǡ ȋǤǤƬ ǡͳͻͻͻǢƬ ǡʹͲͲͻȌ ǦȋƬ ǡʹͲͲͳȌǤ ǡ ȋƬ ǡʹͲͳͶǢǡʹͲͲͻȌǤ ǡ Ǥ Acknowledgement
Ͷ Ǥ ͺͲ ǡǡ Ǧ Ǥ ǡǡǡ Ǥ ǦǤ Availability of data and materials
Ǥ Authors’ contributions
Ǥ ǡǡǡǡǡ Ǥ Ǥ Ǥ ǡ Ǥ Competing interests
Ǥ
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Consent for publication
ͳͷ Ǥ Ǥ ȋǡ ƬǡʹͲͲͳȌǤ Ethics approval and consent to participate
ȋȌ ǡͶʹ͵ͲͺȀͳ͵ǦͲ͵ǦͲǤ Ǥ ǡ ǦǤ ǣ ͶǡǣͲʹǦͲǦʹͲͳǣ ǡǤ ǣ D. Op ‘tǡǤǤͳȋ ͳȌǡʹͲͲ Ϊ͵ͳͶ͵͵ͺͺ͵ͺͻǤ ǣ ǡǡͳͻǡʹ͵͵͵ Ǥǣ ǣ ͶͶǣͲͺ ǦͳͻǦʹͲͳͶ Abbreviations 6 (Z)MLK, Abbreviation for the Dutch term ‘(zeer) moeilijk lerende kinderen’ meaning: children ȋȌǢǡǢ ǡ Ǣǡ Ǣǡ Ǣ ǡ Ǣǡ Ǣ ǡ Ǣ ǡǢ ǡ Ǣǡ Ǣǡ ǢǡǦ ȋȌǢǡ Ǣǡ Ǣ ǡǢǡ ǢȀǡ ȋȌǢ ǣ ȋȌǢǡ Ǣǡ ǢǡǢǡ Ǣ ǡ Ǣǡ Ǣǡ Ǥ References
ǦǡǤǡPsychologicalƬǡǤǤȋʹͲͲͲȌǤǤ Medicine, 30 ǡ͵ͷ–͵ͺǤ
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ǡ ǤǡƬǡǤȋʹͲͲͲȌǤ ǣSchizophrenia research, 44 ʹǤͷǦǤ ȋͳȌǡͶǦͷǤ ǡ Ǥǡǡ ǤǡƬǡǤȋʹͲͲȌǤ British Journal of Psychiatry,189 Ǥ ǡ͵͵–͵ͺǤ Current Opinion in Neurobiology,11 ǡǤȋʹͲͲͳȌǤ Ǥ ǡ ʹ͵ͳ–ͻǤǡǤǡƬ ǡǤȋʹͲͲͻȌǤ ǡ American Journal of Psychiatry, 166 Ǥ . Diagnostic and statistical Manualǡͳ͵ͷͷ of M–ͳ͵ͶǤental disorders ǡȋͶ ǤȌǤȋʹͲͲͲȌǤǡǣ Ǥ ǡǤǤǡ ǡǤǡƬǡǤȋͳͻͻʹȌǤ. ȋ Ȍǣ Archives of General Psychiatry, 49 ȋͺȌǡͳͷ–ʹ͵Ǥ Open ǡǤ ǤȋʹͲͲͻȌǤ ǣǤMedicine, 3 ȋʹȌǡͷͳ–ͷ͵Ǥ ǡ ǤǤǡƬǡǤ ǤȋͳͻͻȌǤPsychoanalyticalǦ ǣ Psychology, 13 ǦǤ ȋ͵ȌǡʹͻǤ ǡǤǡƬ ǡǤȋͳͻͻͻȌǤ American Journal of Psychiatry, 156ǣ Ǥ ǡͳͷ͵–ͳͷͻǤ ǡǤǡƬ ǡǤȋʹͲͲͳȌǤAmerican ǣͳͺJournal of Psychiatry, 158 ǦǦǤ ǡʹͶͶMentalisation–ʹͷͳǤ based treatment: a practical guide. ǡǤǡƬ ǡǤȋʹͲͲȌǤ ǣ Ǥ Handbook of mentalizing in mental health practice. ǡǤǡƬ ǡǤȋʹͲͳʹȌǤ ǣ ǡ Ǥ ǡǤǡǡ ǤǤǡ ǡǤǤǡƬǡ Ǥ ǤȋʹͲͲͻȌǤ ǡ ǡSchizophrenia ǡ ǤBulletin, 35 ȋͶȌǡ͵ͺ–ͶǤ ǡǤǤǡǡǤǡǡ ǤǤǡBritish Journal ofƬ Psychiatry,ǡǤȋͳͻͻͲȌǤ 156 Ǥ ǡͺͲͻ–ͺͳͺǤ ǡǤǡǡ ǤǤǡƬ ǡǤǤȋͳͻͻͶȌǤ ȋȌǣJournal of Child Psychology and Psychiatry, 35 Ǥ ǡͳͶͳͻ– ͳͶ͵ͷǤ
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ǡǤǡǡ Ǥǡ ǡǤǡǡǤǡƬǡǤȋͳͻͻͲȌǤ Ǥ British Journal of ǤPsychiatry, 157 ȋȌǡͺͷ͵–ͺͷͻǤ ǡǤǤǤǡSchizophreniaƬǡǤȋʹͲͲͻȌǤǡ Researc, 109 ǣǦǤ ȋͳȌǡͳ–ͻǤ ǡǤǦǤǡǡǤǡǡǤǡǡǤǡǡǤǡƬ ǡǤǡǤȋʹͲͳͶȌǤ Schizophrenia Bulletin, 40 Ǥ ȋȌǡͳ͵ͷ–ͳ͵ͷǤ Journal of ǡǤȋʹͲͲͻȌǤClinical Psychology, 65 Ǧ Ǥ ȋͺȌǡͺͲ͵–ͺͳͶǤ ǡǤǤǡƬ ǡǤȋʹͲͳͶȌǤSocial cognitionǦ and metacognition in schizophrenia Ǥ Ǥ ǣ ǡǤʹͶͷ–ʹͷǤ Schizophrenia Brüne, M.Bulletin, (2005). 31 “Theory of mind” in schizophrenia: a review of the liǤ ȋͳȌǡʹͳ–ͶʹǤ ǡǤǡǡ ǤǡǡǤǤǡ§ǡǤǡǦ ǡǤǤǡǦǡPLoS 6 One,ǤǤǡǤ 9 ȋʹͲͳͶȌǤ ǦǦǦ Ǥ ȋͳͳȌǡͳͳ͵ͲͺʹǤ ǡǤǤǡǡǤǤǡǡǤǤǡǡǤǡǡ ǤǡƬǡǤȋʹͲͲȌǤ ȋ Ȍ ǣSchizophrenia Research, 91 Ǥ ȋͳȌǡͳͳʹ–ͳͳǤ ǡǤǡ ǡ ǤǡƬ ǡǤǤȋͳͻͻͷȌǤ ǡ Schizophrenia inference:Research, 17 Investigating “theory of mind” in people with schizophrenia. ǡͷ–ͳ͵Ǥ ǡǤ ǤǤǡ ǡǤǡ ǡǤǡǡǤǡǡǤ ǤǡǡǤǡǤ ȋʹͲͳͶȌǤǦ ǣBMC Psychiatry, 14 Ǧ Ǥ ǡʹǤ ǦǡǤ ǤǤǡƬǡ ǤǤȋʹͲͲȌǤǦ ǣTijdschrift Klinische Psychologie. ȋȌ Ǥ37 ȋʹȌǡͳͲ–ͳʹʹǤ ǦǡǤ ǤǤǡǡǤǡƬǡǤǤȋʹͲͲͻȌǤ
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Journal of Personality Assessment, 91
ȋȌǤ ǡͳͷͷ– ͷǤ ǦǡǤ ǤǤǡǡǤǡ ǡǤǡǡǤǡƬǡ ǤǤȋʹͲͳͲȌǤ Relationship between personalityPersonality organizationand Individual and Differences, Young’s cognitive 49 model of Ǥ ǡͳͻͺ–ʹͲ͵Ǥ ǦǡǤ ǤǤǡǡǤǡǡǤǡƬǡ ǤǤȋʹͲͳͲȌǤ . Journal of Personality Assessment, 92Ǧ ȋȌǡͷͻͻ–ͲͻǤ ǦǡǤ ǤǤǡǡ ǤǡǡǤǡǡǤǡƬǡ ǤȋʹͲͳʹȌǤ ǡ . JournalǦ of Personality Assessment, 94 ǣ Ǧ ȋͶȌǡ͵ͺͲ–͵ͻʹǤ ǦǡǤǡǡ ǤǡǡǤǡǡǤǡƬǡ ǤȋʹͲͳͶȌǤ Journal of Sleep Disorders:ǡǡ Treatment and Ǥ Care, ͵͵Ǥ ǡ ǤǡǡǤǡ ǡǤǡƬǡǤȋʹͲͲͻȌǤ ȗBehavior Research Methods, 41 ͵Ǥͳǣ Ǥ ȋͶȌǡ ͳͳͶͻǦͳͳͲǤ ǡǤǡƬJournalǡǤȋʹͲͲȌǤ of Clinical Psychology, 62 Ǧ Ǥ ǡͶͳͳ–Ͷ͵ͲǤAffect regulation, mentalization, and the ǡ Ǥǡ ǡǤǡ ǡǤǡdevelopment of the self. ƬǡǤȋʹͲͲʹȌǤ ǣ Ǥ ǡǤ ǤȋͳͻͻȌǤ American Journal Psychiatry, 153 ǫ ǡ͵ʹͳ–͵ͲǤ ǡǤǤǡǡ Ǥ ǤǡƬǡǤǤȋʹͲͲͶȌǤ ǣJournal of Nervous Mental Disease, ǡ 192 ǡ Ǥ ȋͳȌǡͳʹ–ͳͺǤ Psychosomatics, 36 ǡǤǤȋͳͻͻͷȌǤ ǣ Ǥ ȋ͵Ȍǡ ʹ–ͷǤ ǡǤǡ ǡǤǡƬ ǡ ǤȋʹͲͲͳȌǤ Journal of Personality ǤAssessment, 77 ȋ͵ȌǡͶͲͺ–ͶͳͻǤ
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ǡǤǤǡ ǡǤ ǤǡǦǡǤǡ ǡǤ Ǥǡ ǡ ǤǤǡƬǡǤ ȋʹͲͲȌǤ ǣ Biological Psychiatry, 59 Ǥ ǡͳͲͲͳ–ͳͲͲͷǤ ǡǤǡǡ ǤǡǡǤǡ ǡǤǤǡ ǡǤǤǡ òǡǤǡǤȋʹͲͳ͵ȌǤ Psychotherapy Research, ȋ 23 ǦȌǣǡ Ǥ ȋȌǡͲͷ–ͳǤ ǡǤǤǡ ǡǤǡƬǡǤǤȋͳͻͺȌǤ ȋȌSchizophrenia Bulletin, 13 Ǥ ȋʹȌǡʹͳǤ Essential papers on ǤǤȋͳͻͺȌǤǤ ǣ Ǥborderline disorders: One hundred years at the border. ǣǤ ǡǤ Ǥǡ ǡǤǡǡǤǡ ǡǤǡǡǤǡƬǡǤǡǤȋʹͲͳͲȌǤ ǣ Journal of Nervous ǡǡ Ǥ and Mental Disease, 198(6 Ȍǡ͵ͻͻ–ͶͲ͵Ǥ ǡ ǤǤǡǡǤǡǦǡǤ ǤǡǡǤǡǡǤǡ ǡǤǡǤȋʹͲͳʹȌǤ ǣ Psychiatry, 75 Ǥ ȋͶȌǡ͵ͷͷ–ͶǤ ǡǤ Ǥǡǡ ǤǤǡǡǤǤǡ ǡǤǤǡƬǡǤ ǤȋʹͲͳͲȌǤ Schizophrenia Bulletin, 36 6 ǣǦ Ǥ ȋͷȌǡͳͲͻ– ͳͳͻǤ ǡ ǤǡǡǤǡǡǤǡǡǤǡǡǤǡǡ ǤǤǡǤȋʹͲͳͶȌǤ ǤSchizophrenia Research, 152 NVM, ȋͳȌǡʹͳNederlandse–ʹʹʹǤ Verkorte MMPI, handleiding, herziene versie ǡ ǤǡƬǡǤǤȋͳͻͺͷȌǤ Ǥ ǣƬǤ Handbook ǡǤǡ ǡǤǡ ǡǤǡof mentalizing in mental healthƬǡǤȋʹͲͳʹȌǤ practice Ǥ ǤǤͶ͵–ͷǤ ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͲȌǤ ͵ʹ ǣ ǤPsychotherapy Research, 17 ȋȌǡͳ͵–ʹͲǤThe global burden of disease: 2004 update. ǡǤǡ ǡǤǤǡƬǡ ǤǤȋʹͲͲͺǤȌ ǣ Ǥ ǡ Ǥ ǤȋʹͲͲͶȌǤ ȋȌ ǣComprehensive handbook of psychological assessment. Ǥ ǡ ǣǡǤ͵ͳͷ–͵ͶʹǤ
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ǡ ǤǡƬǡǤȋʹͲͲ͵ȌǤ Journal of Trauma Practice, 2 Ǥ ȋʹȌǡͳͻ–͵ͷǤ ǡǤǡǡǤǡǡǤǡǡǤǤǡPsychologicalƬǡǤȋʹͲͲȌǤ Medicine, 37 Ǥ ǡͷͻͷ–ͲͳǤ ǡǤǡ ǡǤ ǤǡƬǡǤ ǤȋʹͲͲͳȌǤǣ BMC Medical Research and Methodology, 1 Ǥ ȋͳȌǡʹǤ ǡǤǡ ǡǤǡǡǤƬ ǡ ǤȋʹͲͲȌǤǡSchizophrenia Research, 92 Ǧ Ǥ ǡͺͷ–ͺͻǤ ǡǤǤǡƬǡǤǤȋʹͲͳ͵ȌǤAnnals of biometrics & biostatistics, 1 Ǥ ȋͳȌǤ ǡǤǡƬǡǤǤȋʹͲͲȌǤ ǣ Current Opinion in Psychiatry, 20 Ǥ ȋȌǡ ͳͻ–ʹͷǤ ǡǤǤǡ ǡǤǤǡƬǡǤǤȋͳͻͺȌǤ Medical Care, 24 Ǧ ǤThematic Apperception Test. ȋͳȌǡ–ͶǤ ǡ ǤǤȋͳͻͶ͵ȌǤ ǡǣ Ǥ Ǧ ǡ ǤǡƬǡ Ǥǡ ǡ ǤǤǡǡǤǤǡǡǤǤȋʹͲArchives General Psychiatry,ͲͳȌǤ 58 Ǥ ǡͳͳ͵–ͳͳͶͶǤ Ǧ ǡ ǤǡƬǡ ǤȋʹͲͲȌǤClinical PsychologyǦ ǣ Review, 27 Ǥ ǡͶͲͻ–ͶʹͶǤ Ǧ ǡ Ǥǡ ǡǤǡǡǤǡǡ ǤǡǡǤǡƬǡ ǤȋʹͲͲͻȌǤ ǣ ǤPsychological Medicine, 39 ȋͲͻȌǡͳͷ͵͵–ͳͷͶǤ ǡǤǡǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͳ͵ȌǤ ǣ Journal of Personality Ǥ Disorders, 27 ȋͷȌǡͳ–ʹͶǤ ±ǡǤǡǡǤǡƬǡǤȋʹͲͲ͵ȌǤ Psychological Medicine, 33 ǫ Ǥ ȋͲȌǡͳͳͶͻ– ͳͳͲǤ ǡǤǡǡǤǡǡǤǡƬǡ ǤȋͳͻͻʹȌǤǡ Schizophrenia Research, 6, Ǧ Ǥ ʹͷ–ͷǤ ǡǤǤǡǡǤǤǡ ǡǤ ǤǡƬ ǡǤǤȋʹͲͳͷȌǤ Schizophrenia Bulletin ǣ Ǥ ǡǣ ͳͲǤͳͲͻ͵Ȁ ȀͲͷǤ
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ǡǤ ǤǡƬ ǡǤ ǤȋʹͲͲͶȌǤ Behavior Research Methods, Instruments and Computers, 36 Ǥ ȋͶȌǡ ͳ–͵ͳǤ ǡǤǡƬ ǡǤȋʹͲͳ͵ȌǤ ǡǡ ǣǦ Ǥǣ Ǣ ǡǤǡ ǡǤǡǡǤǡƬǡǤȋͳͻͻͻȌǤ ). International Journal of Social Psychiatry, 45 ȋ ȋͳȌǡ–ͳʹǤ ǡǤǤǡƬǡǤǤȋʹͲͲͻȌǤ ȋ ȌPsychiatry Research, 166 ǣǤ ǡͳͶͳ–ͳͶǤ ǡǤǤǡƬ×ǡǤȋʹͲͳ͵ȌǤ ȋȌSchizophrenia Research, 150 ǣ Ǥ ȋͳȌǡͶ–ͺǤ ǡǤǡǡǤǡ ǡǤǡǡǤǡÞǡǤǡǡǤǡǤȋʹͲͲȌǤ Ǧ ǣWorld Psychiatry,Ǧ 5 Ǥ ȋʹȌǡͳͲͲ–ͳͲ͵Ǥ ǡǤǡ ǡǤǡǡǤǡÞǡǤǡǡǤǡǡǤǡǤȋʹͲͳʹȌǤ Psychiatry, 75 Ǧ ǣǦ Ǥ StatiȋͶȌǡ͵͵ͳstical– ͵ͶͳǤMethods in Medical Research, 8 6 ǡ ǤǤȋͳͻͻͻȌǤǣǤ ȋͳȌǡ ͵–ͳͷǤ ǡǤ ǤǡǡǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡǤȋʹͲͲȌǤ ǣ ǤSchizophrenia Research, 90 ȋͳȌǡ͵ͳ–ʹͶǤ ǡǤǡǡ Ǥǡ ǡǤǡǡǤǡǡǤǤǡǡ ǤǡǤȋʹͲͳͳȌǤJournal of the ǣ ǤAmerican Academy of Child and Adolescent Psychiatry, 50 ȋȌǡͷ͵Gedachten–ͷͶǤ uitpluizen: ǡǤǡVaardigheden oefenboek.ǡǤǤǡǡǤǤǡ Cognitieve gedragstherapieƬǡǤ ǤȋʹͲͲͷȌǤ bij achterdocht en stemmen. ǣ Ǥ CBT for Those at Risk of a First Episode ǡǤǡǡǤǡPsychosis: Evidence-basedƬǡǤȋʹͲͳ͵ȌǤ Psychotherapy for People with an ' at Risk Mental State. ǣǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤȋʹͲͳʹȌǤ ǣSchizophreniaǦ Bulletin, 38 Ǧ ǡ Ǧ Ǧ Ǥ ǡͳ–ͳǤ
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Journal of Personality
ǡǤȋͳͻͻͳȌǤ ǤAssessment, 56 ǡͷ–ͶǤ ǡ ǤǤǡǡǤǤǡƬ ǡǤ ǤȋʹͲͲͲȌǤ ȋȌ Psychopharmacology, 150 Ǥ ǡ͵ͻͻ–ͶͲ͵Ǥ ǡǤǡǡǤ Ǥǡ ǡǤǡǡǤǤǡComprehensiveƬǡ ǤȋʹͲͲͷȌǤ Psychiatry, 46 Ǥ ȋʹȌǡͳͶ–ͳͷͶǤ
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Chapter Seven:
ǣ Psychological Medicine (2020) ǦǡǦ ǡ Ǥ J.MENTALIZATION Weijers 1,2**; C. ten Kate1; W. Viechtbauer2; L.J.A. Rampaart BASED1; E.H.M. Eurelings3*; J.P. Selten1,2
TREATMENT FOR PSYCHOTIC DISORDER: A RATER-BLINDED, MULTI-CENTER, RANDOMIZED CONTROLLED TRIAL 7
ͳ ǡ ʹ ǡ ǡǤ ͵ J. ǡ ǡ G. Weijers, C. ten Kate, W.V. Viechtbauer, ǡ ǡǤ ȗȗL.J.A. Rampaart, E.H.M. Eurelings-Bontekoe, J.-P. C.J. Selten ǣ ǤǣǤ̷ǤǤ Psychological Medicine (2020) Chapter Chapter
146807_JonasWeijers_BNW_def.indd 133 28-10-2020 15:08 Chapter Seven
Abstract Background.
–̵ ̵– Ǧ ȋȌǤ ȋȌȋȌ ǤMethods. ǡǦǡ ǤǦ Ǥ ͳͺ ǡ Ǥ Ǥ Ǧ Results.ǦǤ p ǦǦ p Ǧ ȋ αǤ͵ͳȌǦǦȋ αǤͲ͵ȌǤ ǡp ȋ αǤͲȌǤǡp ȋ αǤͲͶͻȌ ǡ ǤConclusion. ǡ Ǥ Introduction
Ǧ ȋȌ ǡ Ǥ ǡ ȋƬ ǡʹͲͲͶȌ– Ǥ ǡ ability to infer others’ mental states, i.e. ‘Theory of Mind’ (Sprong et al., 2007; Bechi et al., 2020), identify and describe one’s own and others’ emotional states (O’Driscoll, Laing & Mason, ʹͲͳͶǢ±ǡʹͲͲǢǡǡǡ ǡǡʹͲͳͲȌǤ ȋ ǤʹͲͳͳȌǡ ǡ ǡ ȋǤǤǡǦʹͲͳǢ ǤǡʹͲͳͻǢÚ Ǥǡ ʹͲʹͲȌǡ Ǧ Ǧ Ǧ ȋòǡǡʹͲͳͳȌǤ
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ȋȌ Ǧ ȋƬ ǡͳͻͻͻȌǡ Ǧ ǡ Ǧ ǡ Ǥ ǡ ȋʹͲͲͳǢʹͲͲͺȌ ͳͺ Ǥ ȋǤʹͲͳʹǢǤǡʹͲͳͺȌǤ ȋƬ ǡʹͲͳͶǢǤǡʹͲͳǢǤǡʹͲʹͲȌ ȋ±ǤǡʹͲͳȌǤ ǡ ȋȌ ȋȌǤ ǡ Ǥǡ ǣǢǡǡǡǢ ǢǢ Ǣ Ǣ Ǣ ȋǤǤǡ ȌǤ Methods
ȋ ǣͶͷͺͺȌǡ 7 ǤǤet al. Participants and procedure.ȋʹͲͳȌǤ ȋ Ȍ Ǥ ǣǡ ͳͲǢͳͺͷͷǤ ǣ Ȁ Ǣ Ǣ Ǥn ȋ αͳʹȌ Ǥǡ Ǥ ǡ Ǥ ǡ Ǥ ǡ ǡ
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another investigator blind to the patient’s treatment allocation. In three cases blindness was Ǥ Ǧ ȋǡʹͲͲͲȌ Ǥ Randomization, ȋ ǢǤǡͳͻͺʹǤȌ treatment allocation and rater blindness: Ǥ ǡ Ǥ ǡ ǤǤ Ǧ allocation, they were not informed of the participants’ allocation and participants were Ǥ ǡ ǡ Ǥ ǤTherapy. Treatment as usual.
et al Ǧ ȋ ǤʹͲͳʹȌ Ǧ ‘F Assertive Community Treatment’ (FACT) model. FACTǦ ǡ ǡ ǤMBTp. Ǥ ǡ ǡǡ ȋ ƬǡʹͲͲȌǤ ǡ ǡ ǡ interventions and stress, and adopting a ‘notǦknowing’ therapeutic stance. T –ͳͺ– ǡ ǦǦ Ǥǡ Ǥ ǣ ǡ ǡ ǡ Ȁ ǡ ǤMBT therapists. ǡ ȋα͵Ȍǡ ȋαʹȌǡȋα͵Ȍ Ǥ
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ȋαͳȌȋαͳͳȌǤ ǦǦ ȋȌǤ ǡ Ǥǡ – Ǧ– ǡ Ǥ Ǧǡ ȋǤǡʹͲͳ͵Ȍ, and found nthe therapist’s competence and adherence to the MBT model to be ‘good enough’ (4), ‘good’ (5, =2) and ‘very good’ (6). Note that in Karterud et al.’s (2013) Ǥ ǡ Ǥ Assessment. ǣ ȋͲȌǡͳͺǡǦȋʹȌǡǦ Ǧ ȋ͵ȌǤDiagnosis. ȋȌͻȋͳȌǤ ͳǦ ǦȋǡʹͲͲͲȌ Ǥ et al. ȋ Ǣ ͳͻͻʹȌǡ Ǥ ǡ Ǧ ǡ ȋ̵ 7 κ = 0.6).Primary outcome. Social functioning.
et al. ȋ Ǣ ͳͻͻͲȌǡ ǣ ǡȀ ǡ Ǧ ǡ Ǧ ǡ ǡǦ ǡ Ȁ Ǥ ǡ ȋǣͷͻǤͳ͵ͶǤͻȌǤ The SFS is often referred to as ‘behaviorally anchored’ because it uses ȋǤǤǡȌ Ǥ ǡet al. ǡ Secondary outcomes. ȋ ͳͻͻͲȌǤ Mentalizing ability
ȋǢǡ ͳͻ͵ͺȌ ȋǢǡͳͻͻͳȌǤ
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ǣ ȋǤǤǡ the ability to distinguish between one’s own and another’s perspective), understanding of social ȋǤǤǡ of others’ Ȍǡ ȋǤǤǡ Ȍǡ ȋǤǤǡ ȌǤ Ǧ ǡ Ǥ et al. ȋ ͳͻͻͷȌǡ ʹͲǦ ǡPositive symptoms Ǥ / Negative symptoms / Depression / Anxiety / Lack of insight et al ȋ et al. ǤʹͲͲͲȌ ȋǢ ͳͻͺȌet al.Ǧ Ǥ ȋQuality of life ʹͲͳȌǤ et al. ȋExperiencͳͻͻͻȌǤe sampling variables. –the ‘PsyMate’ – ǡǤǤǡ ȋȌǤ Ͳǡͳǡʹǡ͵ǡǡ Ǥ ǡ positive affect (an average score of “happy”, “satisfied”, “cheerful”, “relaxed”, and “enthusiastic”), negative affect (“anxious”, “lonely”, “insecure”, “irritated”, “down”, “guilty”, and “gloomy”), psychotic symptoms (‘I feel suspicious’, ‘I am afraid of losing control’, ‘I feel that others don’t like me’, ‘I feel that others want to hurt me’, ‘My thoughts are influenced by other people’, ‘I f unreal’, and ‘I hear voices’), and social stress (“I would rather be alone” and “I like the present company” (reverse coded)) they experienced. All items were rated on 7Ǧ Ǥ ǡ ǡ ͲͳȋȌǤModerators. Personality organization and somatization of psychopathology.
et al. ȋǦ ǡʹͲͳʹȌ ȋ ǢƬǡͳͻͺͷȌǤ ȋȌ ǣ ǡǡ ǡ Ǥ ǡ
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Ǥ ȋChildhoodǦƬǡʹͲͲȌǤ trauma. et al. ȋǢ ͳͻͻͶȌǦ Ǧ Ǥ ȋ ǡȌǡ ǡ ǡ ǤAdherence to pharmacological treatment. et al. ȋǢDuration of illness. ͳͻͺȌǤ ǤStatistical analyses. Main analyses
Ǥ ǡǦǦ – Ͳʹ͵– Ǥ ǡ ǡ– Ǧ ǡ ʹ͵–ǡ Ǥ ȋʹͲͳȌǡ Ǥ ǡǡ – Handling– Ǥ of missing data. 7 carried out with imputed data, allowing for the use of a proper ‘intentionǦǦtreat’ analysis. ȋ ǡͳͻͻͻȌ Ǧǣ ǡǡǡǡ ǡǡ et al. ǡ Ͳȋ ʹͲͲ͵ȌǤ ǡͷ ȋȌ Ǥ Mediation analyses.were combined using Rubin’s rules. ǡ ǡ affected by treatment condition. SPSS version 22 combined with Hayes’s PROCESS macro ȋ Ƭ ǡʹͲͲͶȌǤ Ǧ ǡ ȋ ȌǤ
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ͷͲͲͲǤ ͲǤ ǡ ʹ͵ ǡʹ͵ Moderation analyses. et al. Ǥ ȋʹͲͳȌǡ ǡ ǣ ǡ ȋȌǡ ǡ ǡǡ Ǥ ǡ ǡ Ͳ ǡ ʹ͵Ǥ ǡǦ ȋ ǡǡ ǡ ȌǤǡ ͷȋ Ƭ ǡͳͻͻ͵Ȍ ȋ Ƭet al. ǡͳͻͻ͵Ǣ ʹͲͳͲȌǡ ȋδαͷεͷ ȌǤ ȋ Ȍ ȋ ȌǤMultilevel analyses. ǡ ǡ Ǥ ǡ ǡͲ ʹͶͲǤ et al. Ǥ ǡ ȋǤǤǡ ʹͲͳȌǡ ʹͲǤ ǦǤ ȋǤǤǡ Ȍ ǡ ǡ ǡ Ǧ Ǥ Ǧ Ǥ ǡ ȋ Ͳ͵Ͳ͵ǡ Ȍǡ ǡ ǡ ǡ ǡ ǡ Ǥ ȋǤǤǡ ǫȌǤ
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ȋ Ȍ ǡ ǡ ȋ ȌǤ ǡǡ ǡ ǦǦ ǡ ǡ ǡ Ǥ Ǥ ǡ Ǧ ȋǤǤǡ ǫȌǤComparison of medication type and dosage. ǡ ȋ ͳȌǡ ȋ ʹȌ ȋ ͵ȌǤ Ͳǡʹ ͵Ǥ ȋͳͲͲȌ ǡ ǤȋʹͲͳͲȌǤǡ ȋͲǡʹǡ͵ȌȋȌ Ǥ ʹ͵ǡͲ Ǥ Results Demographics and patient characteristics.
7 ͻͲ Ǥ ǡ Ǥ ǣ ǡ ȋͷȌǤ Ǥ ǡǦǦ ͺͶǤ p ǡ ȋ αǤͲͶͻȌǡ ǤʹǤ ʹͳbefore ȋȌ ǡʹ͵during Ǥ ǡ Ǥ p p p ȋ ’s > .31), type (all ’s > .27) or dosage (all ’s εǤʹͷȌͲǡʹ͵Ǥ
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Table 1. Demographics and clinical characteristics of patients at baseline participating in a randomized trial to test the effectiveness of mentalization-based treatment for psychotic disorder. Variable TAU, mean (SD) N MBT-P, mean (SD) N p*
͵ͳǤͺͺȋͻǤͶ͵Ȍ Ͷʹ ͵ͳǤʹͳȋǤͺͲȌ Ͷʹ Ǥ͵ ʹǤͳȋͻǤͳͳȌ Ͷʹ ʹͷǤȋǤͷͳȌ Ͷʹ ǤͲ ͷǤͳȋ͵Ǥ͵ʹȌ Ͷʹ ͷǤͶͷȋ͵ǤͷͶȌ Ͷʹ ǤͲ Ǥͳʹ ǡ͓ ͵Ͳ ʹ͵ ǡ͓ ͳʹ ͳͻ ȋǦ ǦȌ Ǥ ʹͺ ʹ Ͷ ǤǤǤ ʹ ʹ ʹ Ͳ Ǥͷ Ͷ ʹ ʹͷ ʹͺ ͳͲ ͵ ͷ ȗ Ǧ Ǧ Ǥ Drop-out and non-compliance.
ͳǤ ʹͻǤͻȋǣͲǦͺȌͺǤ ȋǣͲǦʹͲȌǤ
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7
Figure 1. Ǥ
Safety. Ǧ ǡ Ǥ ǡ Ǥ
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Ǥ ǡ ǤMain Analyses. Primary outcome.
F ǦǦ 2 p ȋ ȋͳǡͶͳȌαʹͳǤͷʹǡηp αǤ͵Ͷǡ F δǤͲͲͳȌ p 2 ʹȋ ȋͳǡͶͳȌαǤͶǡηpαǤͳͷǡ αǤͲͳȌǤ ȋͳͻͺͺǢǤͲͳαǢǤͲαǡǤͳͶαȌǡ Ǥ͵ǡF p 2 ǡ ȋF ȋͳǡͶͳȌαʹǤʹͷǡηpαǤͲͷǡp α 2 ǤͳͶȌǡ ȋ ȋͳǡͶͳȌαʹͲǤͻͻǡηpαǤ͵Ͷǡ δ ǤͲͲͳȌǤǦǦ ʹt p t 2 2 pȋ ȋͺͲȌαͳǤͲͳǡηpαǤͲ͵ǡ αǤ͵ʹȌǡ ͵ȋ ȋͺͲȌαʹǤͳǡηpαǤͲǡ αǤͲ͵ȌǤSecondary outcomes. ʹ Ǥ
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Table 2. Results of the intention-to-treat ANCOVAs* comparing the effectiveness of mentalization-based treatment for psychotic disorder (MBT-p) with treatment as usual (TAU). 7
ȗǦǦ Ǥ
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Mediation analyses.
Ǧȋ͵Ȍ Ǥǡ Ǥ ͵Ǥ b p ͵ b pȋ αͲǤͻǡ αǤͲͶȌǡ ȋ αͲǤ͵ͻǡ αǤʹͷȌǤǡ ǡ b p ȋ αͳǤͷͳǡ αǤʹȌǡ Ǥ ǡ ͲȋͻͷΨ ȏǦ ͲǤͲͲʹǡͲǤ͵͵ȐȌǤModeration analyses. ǡ ǡǡǡp ʹ͵ȋ ’s > .07). However,F duration of illnessp cantlyR moderated the treatmentp effect on social functioning at T3 (Δ ȋͳǡͷͺȌαͶǤͲͷǡ α .049, Δ ʹαǤͲͷȌǡʹȋ αǤ͵ͺȌǤ ȋδαͷȌF p 2 ȋ M SD ȋͳǡ͵͵ȌαͳͲǤͷͲǡηp αǤͳǡ αǤͲʹȌ͵Mȋ αͳͳǤͷͺǡSD αǤͳȌ ȋεͷȌ M ȋSD αͳͲͻǤͻͷǡF αǤͲͶȌ ȋp α 2 ͳͳͳǤͶͲǡMultilevelαǤͳǢ analysis.ȋͳǡ͵ͶȌαǤͶͺǡ ηp αǤͳǡ αǤͲʹȌǤ ǡ ǡ b p ȋ αǦͲǤ͵ʹǡͻͷΨ ȏǦͲǤͷͺǡǦͲǤͲͷͻȐǡ αǤͲʹȌǤ ǡ ǡ ǡ ȋp ’s > .06). The interaction ǡǡ p ǡ ǡ ȋ ’s > .12), Ǥ Discussion Main findings.
Ǥ ǦǦ ǡ ǦǤ Ǥ ǡ
ǡ ǦǦǤǡ
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Ǧǡ ǤInterpretation and comparison to previous findings. ǡ Ǧǡ Ǧǡ Ǧ Ǥ et al ȋ ǤʹͲͳ͵ȌǤ – Ǧ et al et al – ȋ ǤʹͲͳʹǢ ǤʹͲͳͻȌǤǡ appeared to be more robust in the MBTp group, which may be attributed to the ‘sleeper effect’ Ǧ Ǥ ȋʹͲͲͳȌ Ǥ ǡ Ǧ ǦǤ ǡ ȋαȌ ǦǦ ȋαͳȌǤ ǦǤ Ǧ ȋǤʹͲͳͺȌǡ Ǧn Ǧ Ǥ ǡ n Ǧȋ αͷȌȋ αͲȌǡ Ǧ 7 ǦǤ Interestingly, while the evidence for MBT’s p et al. – – ȋ ʹͲͳʹȌǡ ǡ ǡ ǡ Ǥ Ǥ ǡdrove Ǥ ǡ Ǥ ǡ Ǥ et al symptoms atet baselineal. were similar to those for remitted patients (Češková ǤʹͲͲͷǢ ʹͲͳͺȌǤ Ǥ ǡ Ǥ ʹͲΨ
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ǡ Ǥ ǡ Ǥ M ǡ ȋM M αͳͳǤͷͺȌ ȋ αͳͲͺǤͲȌ ȋ αͳʹ͵Ǥ͵Ȍǡ ȋʹͲͲͺȌǤ et al. et al. ȋ ʹͲͳ͵Ǣ ʹͲͳͶȌ et al. ȋ Ƭ ǡͳͻͻ͵Ǣ ʹͲͳͲȌǤ et al. ǡ et ȋ al. ʹͲͳͳȌ ȋ ʹͲͳͶȌǤǡ ǡet al ȋ± Ǥ ʹͲͳȌǤ Strength and limitations. ǣ ǡ ǡǤ ǡ ȋƬ ǡ ʹͲͳʹǡȌǤǡ Ǥ ǡǤ ǡ ǡ Ǥ Ǥǡ Ǥ ǡǦʹͲΨǡ Ǥǡ underpowered. Fourth, except for the ‘complexity of representations’ dimension, we Ǧǡ Ǥ ǡ Ǥ Ǥǡ Ǥ Ǥǡ ǡ ǦǡͳͺǤ ǡ ǡ
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ȋǤǤǡƬǡʹͲͲͻȌǡ Ǥ Conclusion
Ǥ Acknowledgements
Ǥ Financial support
ǡ ǦǦ Ǥ Conflict of interest
Ǥ Ethical standards
ͳͻͷǡʹͲͲͺǤ 7 References Schizophrenia
research,ǡ Ǥǡǡ ǤȋʹͲͲͺȌǤ Ǥ ͻͻȋͳǦ͵ȌǡͳǦͳͺͳǤ Diagnostic and statistical manual of mental disorders (4th ed., Text Revision) ǤȋʹͲͲͲȌǤ ǤǡǣǤ ǡǤǤǡ ǡǤǡƬǤȋͳͻͻʹȌǤArchives of ȋ Ȍǣ ǤGeneral Psychiatry ǡͶͻȋͺȌǡͳͷǦʹ͵Ǥ ǡǤǤǡǡǤǡǡǤǡǡǤǡ ǡǤǤȋʹͲͳͲȌǤ Biological psychiatry,Ǧǣ Ǥ ȋ͵ȌǡʹͷͷǦʹʹǤ ǦǡǤǡ Ǧǡ ǤǡǡǤǡǦǡǤǡǡǤ ǤȋʹͲͳȌǤ European Psychiatry ǣǦǤ ǡͶǡ͵͵ǦͶͳǤ
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ǡǤǤǡƬ ǡǤȋͳͻͻͻȌǤ American Journal of Psychiatryǣ Ǥ156 ǡ ȋͳͲȌǡͳͷ͵ǦͳͷͻǤ ǡǤǤǡƬ ǡǤȋʹͲͲͳȌǤAmerican ǣͳͺJournal of Psychiatry ǦǦǤ ǡͳͷͺȋͳȌǡ͵ǦͶʹǤ Journal of PersonalityǡǤǤǡƬ DisordersǡǤȋʹͲͲͶȌǤǦǤ ǡͳͺȋͳȌǡ͵ǦͷͳǤ ǡǤǤǡƬ ǡǤȋʹͲͲͺȌǤͺǦǦ ǣAmerican Journal of PsychiatryǦ Ǥ ǡͳͷȋͷȌǡ͵ͳǦ͵ͺǤ ǡǤǡǡǤǡ ǡǤǡǡ Ǥǡǡ ǤǡǡǤǤǡǤǤǤǡǤ ȋʹͲͳͻȌǤ Psychiatric rehabilitation ǣ journal. ǦǤ
ǡǤǡǡ ǤǤǡƬ ǡǤǤȋͳͻͻͶȌǤ Journal of Childhood Psychology and Psychiatry,ȋȌǣ Ǥ ͵ͷǡ ͳͶͳͻ–͵ͷǤ ǡǤǡǡ ǤǤǡ ǡǤǡǡǤǡƬǡ ǤȋͳͻͻͲȌǤ ǣ The British ǤJournal of Psychiatry 157 ǡ ȋȌǡͺͷ͵ǦͺͷͻǤ Australian and New ZealandǡǤǡƬ Journal of Psychiatryǡ Ǥȋͳͻͻ͵ȌǤ Ǥ ǡʹȋ͵Ȍǡ͵ͶǦ͵ͺǤ ǡǤǤǡƬ ǡǤȋʹͲͳͶȌǤǦ Social cognition and metacognition in Ǥ schizophrenia: Psychopathology and treatment approaches , ȋǤǤ Ǥǡ Ǥ ǡƬǤòȌ ǤʹͶͷǦʹͷͻǤǣ Ú ǡǤǤǡǡǤǡǡ Ǥǡ ǡǤǡǡ Ǥǡ ǡ ǤǡǤǤǤƬǡǤȋʹͲʹͲȌǤ Ǧ ǣ Frontiers in Psychology, Ǥ ͳͳǡʹͻǤ òǡǤǡǡ ǤǡǡǤȋʹͲͳͳȌǤ Current ǣ ǡ ǤPsychiatry Reviews ǡȋ͵Ȍǡʹ͵ͻǦʹͶǤ
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ČeškováǡǤ, PřikrylǡǤ, KašpárekǡǤǡƬOndrušovǡǤȋʹͲͲͷȌǤ Neuropsychiatric Disease and Treatment 1 Ǧ Ǥ ǡ ȋʹȌǡͳͻǤ Statistical Power Analysis for the Behavioral Sciences ǡ (2ǤȋͳͻͺͺȌǤ ǣǤ ǣnd ed.), ǤʹͺͶǦʹͺͺǤ ǣ ǡǤ ǡǤǡ ǡ ǤǡƬ ǡǤǤȋͳͻͻͷȌǤ ǡ Schizophrenia inference:Research 17 Investigating “theory of mind” in people with schizophrenia. ǡ ȋͳȌǡͷǦͳ͵Ǥ ±ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǡǡǤǤǤǤǡƬǡǤǤ ȋʹͲͳȌǤ ǡǡ ǤFrontiers in Human Neuroscience, 10 ǡͶͲǤ ǡǤǡǡǤǡǡǤǡ ǡǤȋʹͲͳͺȌǤ ǣPersonality Disorders: Theory, Research, Ǥand Treatment ǡͻȋͳȌǡʹʹǤ ǡǤǡǡǤǡǡǤǡǡ ǤȋʹͲͳ͵ȌǤ ǣ ǢǤClinical Practice & Epidemiology in Mental Health ǡͻǡʹͲʹ–ʹͲͻǤ ǦǡǤ Ǥǡǡ ǤǡǡǤǡǡǤǡƬǡ ǤȋʹͲͳʹȌǤ ǡ 7 JournalǦ ǣ of Personality Assessment 94 ǦǤ ǡ ȋͶȌǡ͵ͺͲ–ͻʹǤ ǦǡǤ ǤǤǡƬǡ ǤǤȋʹͲͲȌǤǦ ǣTijdschrift Klinische Psychologie, ȋȌ Ǥ 37 ȋʹȌǡͳͲGuideline–ʹʹǤ on multiplicity issues in clinical trials. ȋʹͲͳȌǤ ǣȀȀǤǤǤȀȀ ǦǦ Ǧǡ ͳͲʹͲͳͻǤ ǡǤǤ Ǥǡ ǡǤǡǡǤǤǡǡ ǤǡƬǡǤȋʹͲͳͳȌǤ Neuroscience & Biobehavioral Reviews 35 ǣǦǤ ǡ ȋ͵Ȍǡͷ͵ǦͷͺͺǤ ǡǤǡƬJournal ofǡ ClinicalǤǤȋʹͲͲȌǤ Psychology 62 Ǥ ǡ ȋͶȌǡͶͳͳǦͶ͵ͲǤ
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ǡǤǤǡǡǤǤǡ ǡ ǤǡǡǤǤǡƬǡǤ ǤȋʹͲͳͻȌǤ Journal of Experimental Psychopathology ǣ Ǥ ǡͳͲȋͳȌǡͳǦͳͳǤ ǡ Ǥǡ ¡ ǡǤǡ ǡǤǡǡActaǤȋʹͲͳʹȌǤ Psychiatrica Scandinavica Ǥ ǡͳʹͷȋʹȌǡͳͷǦͳǤ ǡǤǡǡ ǤǡǡǤǡ ǡǤǤǡ ǡǤǤǡ òǡǤǡǤȋʹͲͳ͵ȌǤ ȋǦȌǣǡ Ǥ ǡʹ͵ȋȌǡͲͷ–ͳǤ ǡǤǤǡ ǡǤǡƬSchizophreniaǡǤǤȋͳͻͺȌǤ ȋȌ Bulletin 13 Ǥ ǡ ȋʹȌǡʹͳǦʹǤ ǡǤ Ǥǡǡ ǤǤǡǡǤǤǡ ǡǤǤǡǡSchizophreniaǤ ǤȋʹͲͳͲȌǤ Bulletin, ǣǦ Ǥ ͵ȋͷȌǡͳͲͻ–ͳͳͻǤ ǡǤǤǡǡǤǡǡǤǤǤȋʹͲͳͺȌǤ BMC PsychologyǦ ǡǣǦǤ ǡȋ͵ʹȌǡͳǦͳͲǤ ǡ ǤǤǡǡǤǤǡƬ ǡ Ǥ ǤȋʹͲͳ͵ȌǤJAMA 310 ǣ Ǥ ǡ ȋȌǡͺͻǦͻͲǤ ǡǤǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡ ǡǤǡƬǡǤȋʹͲͳͶȌǤ ǡǫ Psychiatry Research, 216 Ǥ NVM, Nederlandse ȋʹȌǡͳͻͺVerkorteǦʹͲͷǤ MMPI, handleiding, herziene ǡversie. Ǥǡ ǡǤǤȋͳͻͺͷȌǤ ǡǣƬǤ ǡǤǤǡǡǤǡ ǡǤǡƬǡǤǤȋʹͲͳͲȌǤ ǣ The Canadian Journal of Psychiatry 55 Ǥ ǡ ȋͺȌǡͶͺǦͶͻǤ ǡǤǤǡ ǡǤǤǡǡǤǤȋͳͻͺȌǤ Medical Care, 24 Ǧ ǤExplorations in personality. ȋͳȌǡ–ͶǤ ǡ ǤǤȋͳͻ͵ͺȌǤ ǡǣǤ ±ǡǤǡǡǤǡ ǡǤǡƬǡǤȋʹͲͲ͵ȌǤ The British Journal of Psychiatry 183 Ǧ ǣǦǤ ǡ ȋ͵ȌǡͳͻǦ ʹͲǤ ̵ ǡǤǡǡ ǤǡƬǡǤȋʹͲͳͶȌǤǡClinical Psychology Review, 34 ǡǦǤ ȋȌǡͶͺʹǦͶͻͷǤ
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ǡǤǡǡǤǡǡǤǡǡǤǡ ǡ Ǥǡ ǡ ǤǤǡǤǤǤƬǡǤȋʹͲͳͺȌǤ ʹͶ Schizophrenia research , 206, Ǥ ͵ͻͶǦ͵ͻͻǤ ǡǤǡ ǡǤǡǡ ǤǡǡǤ ǤǡǡǤǤǡ ǡǤǡǤǤǤ ǡ ǤȋʹͲͳͻȌǤ Journal of consulting and clinicalǦ ǣ psychology Ǥ ǡͺȋʹȌǡͳͷͳǤ ǡǤ ǤǡƬ ǡǤ ǤȋʹͲͲͶȌǤ Behavior Research Methods, Instruments, & Computers 36 Ǥ ǡ ǡ ͳǦ͵ͳǤ ǡǤǡ ǡǤǡǡǤǡƬǡǤȋͳͻͻͻȌǤ International Journal of Social ȋȌǤPsychiatry 45 ǡ ȋͳȌǡǦͳʹǤ ǡǤǤǡǡǤǤȋʹͲͲͻȌǤ ȋ ȌPsychiatry Research ǣǤ ǡͳǡͳͶͳ–ͳͶǤ ǡǤ ǤǡƬ ǡǤȋʹͲͳʹȌǤJournal of theǦ American Academy of ǦChild ǣ & Adolescent ǤPsychiatry 51 ǡ ȋͳʹȌǡͳ͵ͲͶǦͳ͵ͳ͵Ǥ Statistical methods in medical research 8 ǡ ǤǤȋͳͻͻͻȌǤǣǤ ǡ ȋͳȌǡ ͵ǦͳͷǤ ǡǤǡ ǡǤǡ ǡǤǡǡǤǡ ǡǤǡƬ ǡǤȋʹͲͳȌǤ ǣScientific Reports 7 Ǥ ǡǡͶͷʹ͵Ǥ ǡǤǡ ǡǤǡǡǤǡ ǡThe ǤǡƬ British Journal ǡof PsychiatryǤȋʹͲͲȌǤ191 ǣǦǤ ǡ ȋͳȌǡͷǦͳ͵Ǥ MultidisciplinaireǡǤǡ richtlijnǡǤǡ schizofrenieǡǤǡǡǤǡǡ ǤǡƬǡǤȋʹͲͳʹȌǤ Ǥ ǡǣǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǤǡƬ ǡ ǤǤȋʹͲͳȌǤBMCǦ ǣ Psychiatry 16 Ǥ ǡ ȋͳȌǡͳͻͳǤ ǡ Ǥ ǤǡǡǤǡ±ǡǤǡǡǤǤǡ ǡǤǡǡ ǤǤǡǦ ǡǤ ǤǤȋʹͲʹͲȌǤ ǣ Journal of Contemporary Psychotherapy Ǧ Ǥ ǡͳǦͳͲǤ Journal of Personality ǡAssessmentǤȋͳͻͻͳȌǤ Ǥ 56 ǡ ȋͳȌǡͷǦͶǤ
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ǡ ǤǤǤǡǡǤǤǤ Ǥǡ ǡǤ ǤǡǡǤ Ǥǡǡ Ǥǡ ǡ ǤǤǤǡǤǤǤƬ ǡǤȋʹͲͲͲȌǤ ȋȌ Psychopharmacology 150 Ǧ Ǥ ǡ ȋͶȌǡ͵ͻͻǦͶͲ͵Ǥ ǡǤǡ ǡǤǡǡǤǡ ǡǤǤǡƬǡǤȋʹͲͳͳȌǤAmericanǦ Journal of ǣ ǤPsychiatry 168 ǡ ȋͷȌǡͶʹǦͶͺͷǤ
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PART IV:
CONCLUSION
IV Part
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Chapter Eight:
SUMMARY AND GENERAL DISCUSSION 8
J.G. Weijers
Chapter
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Introduction.
ǣ ǡ Ǥ Ǥ ȋǡʹͲͳʹǢ ǤǡʹͲͳ͵Ȍ ȋǦ ƬǡʹͲͲǢǦ ǤǡʹͲͳȌȋǡǡǡƬǡʹͲͲͷǢǡ ǡǡ ǡƬǡʹͲͲȌ Ǥ ȋǤǤƬ ǡʹͲͳͶǢ±ǤʹͲͳȌǤ holds that the level of security in a child’s rearing environment determines how well the ability Ǥǡ Ǥ Ǥ ǡ ȋ ǡͳͻͻʹȌǤǡ ǡ ȋ ǡͳͻͻʹȌǤ ǡ ǡ ȋȌ Ǥ Ǥ Summary of Findings Aim I: To outline how mentalization theory may contribute to understanding and treatment of NAPD.
ʹ – ǡȀ – ǡ Ǥ ǡ ǡ Ǥ ǡ Ǥ ǦǤ
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responsive to their child’ǡǦǡ ȋǡͳͻ͵ȌǤ ǡ ǦǤǡ ǡ Ǥ mentalizing ability. Imagining one’s parent’s hostile or uncaring mindǦ Ǥ ǡǦ ǡ Ǥǡ ǡ Ǥ Ǥǡ ǡ ǡ Ǥ Ǥ Ǧ ǡ Ǥ ǡǤ ǡ Ǧ Ǥ ǡ aware of one’s suspiciousness, one will fail to notice how thisar mentale state influences the
ǡ ǦǤ 8 ǡ Ǥ ǡ Ǥ ǡ –ǤǤ Ǧȋ ǤǡʹͲͳȌ– Ǥ Ǥ ǦǤǡ ǡ ȋ ǡǡƬǡʹͲͳȌǤ ǡ Ǧ Ǥǡ ǡ ǡ ȋ ƬǡʹͲͳͶȌǤ
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ǡǡȋʹͲͳȌ Ǥ ǡ Ǧ Ǥ caregiver’s intentions are benign, which helps the child more readily accept shared informatio Ǥ ǡ regarding others’ messages. Given the high degree of social adversity ȋǤǤǤǡʹͲͳʹȌǡ Ǥ ǡ ǡ Ǥoften show a ‘rigidity’ visǦǦǡ ǡǡǤ ǡ ǡ ǡ ȋǤǤƬ±ǡʹͲͳͺȌǤ ʹ ǡ Ǥ Ǥ Aim II: To test several proposed hypotheses that may explain the relationship between childhood abuse and the severity of symptoms in adult patients with NAPD.
Ǥ ǡǣ ǡ Ǥ Ǥ ǡ ȋǡǡMengelers, Van Os, & Myin‐Germeys, ʹͲͳͳǢǦǤǡʹͲͳͺȌǡ Ǥ Ǥ
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Ǥ ͵ǤʹΨ Ǥ adulthood, and with an impaired ability to infer others’ mental states. Additionally, we observed that an impaired ability to infer others’ mental states may constitute a mechanism by which Ǥ ǡ ǡ ȋȌǤ Aim III: To test whether mentalization based treatment for psychotic disorder (MBTp) is an effective addition to treatment as usual regarding social dysfunction and impaired mentalizing.
ǡ ȋȌ ȋ Ȍǡ ǡ Ǥ ǡ ǡ Ǥ
Ǥ 8 ǡ Ǧ Ǥǡ ǡ causality (i.e. the ability to construct a logical and psychologically minded explanation of others’ ȌǡȋǤǤȌǡ representations (i.e. the ability to distinguish between one’s own and another’s perspective), ̵ȋǤǤ need for treatment). They also showed a greater decrease in social stress (i.e. disliking one’s ȌǤ ǡ ǣǡǡǡ ǡǡ Ǧǡ ǡ ǡǡ Ǥ
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Comparison to previous studies Mentalization, psychosis and childhood abuse.
how ȋǤǤǤǡʹͲͳʹȌǤ Ǥ ǡǡ ǡ Ǥ ȋǤǤǡǦ ƬǡʹͲͲǢǦǤǡʹͲͳȌǤ ǡ ǡǡ ǡǤǡ ǡ ǡ Ǥ ǡ ǡǦ Ǥ ǡ ȋǤǡ ʹͲͳȌǡ ȋǡǡǡƬ ÚǡʹͲͳȌǡ ȋƬ ǡʹͲͳͶȌǡ ȋ ǤǡʹͲͳȌǡ ȋ ǤǡʹͲͳ͵Ȍ ȋǡ ǡ Ǧǡ ±ǡƬǡʹͲͳͻȌǤ ǡ ȋ±ǤǡʹͲͳȌ ǡ ȋ ǤǡʹͲͳͻȌǡ ȋǤǡʹͲͳȌǤ ǡ ȋ ǡ ǡƬ ǡͳͻͻͷǢwas Bartels‐Velthuis, Blijd‐Hoogewys, & Van Os, ʹͲͳͳǢǡǤǡʹͲͳȌǤ ȋ Ƭ ǡͳͻͻͻ ǢǤǡʹͲͳȌǤ ǡ ǡ ǡ ǡǦǤ Ǧǡ mentalizing, or the ability to detect and critically reflect upon one’s sensoryǦ experiences sometimes referred to as ‘embodied mentalizing’ (Debbané & Toffel, 2019)ǡ Ǥ ǡǦ
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ȋǤǤMentalizationǡƬǡʹͲͳ͵ based treatment for psychoticȌǤ disorder. Ǥ ǡ Ǥ Ǥ Ǧ ǡ ǡ ȋ Ȍ Ǧ ǡ Ǥ ȋǤǤǡ ǡǡƬǡʹͲͳ͵Ȍǡ ȋǡǡǡ ǡƬǡʹͲͲȌǤǡ ȋǤǡʹͲͲȌǡ Ǥǡ – – ȋ ǡ ¡ ǡ ǡƬǡʹͲͳʹǢǤǡʹͲͳͻȌǤ ǡ ǡ
ǤǦ 8 ǡ Ǥ ǡ after termination of treatment, sometimes referred to as the ‘sleeper effect’. Several metaǦ ȋǡ ǡ ǡƬǡʹͲͲͻǢǡʹͲͳͲǢƬǡʹͲͳͳǢǡǤǡʹͲͳʹǢ Ƭ ǡʹͲͳͶǢǡƬǡʹͲͳͶǢ ǤǡʹͲͳͷȌǡ ȋǡǡƬ ǡʹͲͲͷǢǡǡ ǡƬ ǡʹͲͲȌǤ ȋȌǡ Ǧ ǡ Ǧ ǡ Ǥ ǡ
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ȋʹͲͲͳǢʹͲͲͺȌ ͳͺ Ǥͳ͵Ψ ǡ ͺΨǤ ǡ ǡ Ǥ ǡ ǤǡǤ ǡ Ǥ ǣ ǡǦ patient and therapist; the identification of recurring pathological patterns in a patient’s Ǣ a patient’s affects in relation to their past; pointing out and helpi Ǣ Ǥ ǡ ǡ ȋƬ ǡʹͲͲͲȌǤ ǡ ǡ ional ways to deal with life’s challenges. Compared to more symptom ǡ ǡ –or ‘unconscious’ –reactions to life’s stresses that are deemed dysfunctional (Shedlerǡ ʹͲͳͲȌǤ Ǥǡ ǡ ǡ ȋǡʹͲͳͺȌǤ ǡ ǡ ǡ ǡ ǦǦǡ ȋǤǡʹͲͲͺȌǤ ǡ ǡ ȋ ƬǡʹͲͲȌǤǦ ȋƬ ǡʹͲͲͳȌǤ ǡ ȋʹͲͳʹȌǤ ȋʹͲͳͺȌ Ǥ ǡ
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ǡ ǦǤ ǡ Ǥ Ǥ ǡ Ǧǡ ǡ ǤN ȋǤǤǤǤǡʹͲͳͺǢ αͳͷȌ Ǥp ȋ αǤͲȌ Ǥǡ ǡ Ǥ Ǥ somewhat diminished the centrality of mentalizing’s hypothetical role as a d Ǥ ǡ±ƬȋʹͲͳͻȌ ǡ Ǥ ǡ ǡ ǡ ȋ±ǤǡʹͲͳȌǤ ǡ ȋǦ ǡǦ ƬǡʹͲͳͳȌǤ
Furthermore, in a recent reconceptualization of MBT’s mechanisms of ǡ ǡ 8 ȋʹͲͳȌ Ǥ ǡǡ contingently to the patient’s emotions with mǡ Ǥǡ Ǧ ǡ Ǥ perspectives about one’s self in relation to his social world. as a tool to reinstate the patient’s trust that others are wellǦǡ ǡ ǦǤ Ǥ ǡ ǡ Ǧ Ǥ
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Ǧ ǡ ȋǤǡʹͲͳʹȌ ȋǡǡǡ ǡƬ ǡʹͲͳȌǤ ǡ ȋƬ ǡͳͻͻͻǢʹͲͲͳǢʹͲͲͺǢ ǡ ʹͲͳ͵ǢǤǡʹͲʹͲȌ ȋǤǡʹͲʹͲȌǤ Ǥ ǡ patient’s ability to relate to others, participate in society and benefit from treatment Ǥ Ǥ ǡ ǡ ǡ Ǥ ȋ Ƭ ǡͳͻͻ͵Ȍ ǡǡǡ ǡ ȋȌ Ǧ ȋƬ±ǡʹͲͳͺȌǤin between ǡ Ǥ ǡȋʹͲͳͶȌ ǡ Ǥ Ǥ ǡ have smaller, more fragile social networks, and as a consequence may find themselves with ‘less to work with’. ȋ ǤʹͲͳͶȌ ȋǡƬ ǡʹͲͳ͵Ǣ ǤʹͲͳͶȌǤ n that the first years after onset comprise a ‘critical period’ for intervention ȋǤǤ Ƭ ǡͳͻͻ͵Ǣ ǡǡ ǡƬǡʹͲͳͲȌǡ MBTp in the therapeutic landscape. ȋ±ǤǡʹͲͳȌǤ ǡ Ǥ ǤȋȌǡǡ ǤCBT for psychosis (CBTp), aims to increase a patient’s
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Ǥ ȋǡ ǡǡƬǡʹͲͲͷ ȌǡǦȋǤǡʹͲͳͷǢƬǡʹͲͳǢǡ ǡǡǡƬǡǤǡʹͲͳͺȌǡȋ ǡǡƬ ǡ ʹͲͳͻȌǡ ȋ ǤǡʹͲͳͷȌǤǡ Ǧ ȋ ǡǡƬ ǡʹͲͳare ȌǤ ǡ ǡ Ǥ ǡ Ǥ Ǧ ȋ ǡʹͲͳͶȌǤǡ Ǧ ǡ Ǧ ȋǡǡǡƬǡʹͲͲͺǢ ǤǡʹͲͳͶȌǤ ǡ ȋ ǡƬ ǡʹͲͳͻȌǤǡ ǡ ȋǡǡǡ ǡƬ ʹͲͳͺ ȌǦȋ ǤǡʹͲͳʹȌǤ ǡǡ deemed unfair, as CBT was never developed to take a ‘holistic’ approach to patient treatment, Ǥ More akin process to MBT, are the so called ‘third wave’contents cognitive behavioral therapies, which
ǡ 8 ȋǢƬǡʹͲͲȌǡǦ ȋǢǤǤǡ ǡƬǡʹͲͲͶȌǡ ȋ Ƭ ǡʹͲͳͻ Ȍǡ ȋ Ǣ ǤǡʹͲͳͺȌǤ Ǧǡ ǡ Ǥ Ǥ Ǥ Ǧǡǡ ǡ ǡǡ Ǥ ȋ ǤǡʹͲͳͷȌǤ Ǥ
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MBCT aims to help patients develop ‘mindfulness’, defined as the ability to be the here and now and to be aware of one’s thoughts and emotions without judgment. Embracing –– ȋ ǡǡƬǡʹͲͲͷȌǤ ǡ ȋǡǡ ǡƬ ǡǤʹͲͳʹȌǡ ȋ ǤǡʹͲͲͷȌ ȋǡ ǡ ǡƬǡʹͲͳ͵Ȍ ȋ ǤǡʹͲͳȌǤ ǡ order cognitive processing, or ‘metacognition’ in the case of MERIT. MERIT focuses on the ȋ Ȍ Ǥǡ ǡ Ǥ ǡ Ǧȋ ǤǡʹͲͳͺȌǤ ǡ ȋǦ Ȍ Ǧǡ Ǥ ǡ ǡ ǡ Ǥ ǡ psychotic symptoms, including theory of mind (i.e. the ability to infer other people’s mental Ȍǡ ǡ ȋǤǤ Ȍǡ ȋǤǤ ȌǡȋǤǤ ǢǤȋʹͲͳȌȌǤ ǡ ǦǦǡ Ǥ ǣ ǦǦ Ǧ ǡ Ǥ ǡ
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ǡ ȋis Ƭ ǡʹͲͳͻȌǡ ȋ ǤǡʹͲͳͻȌǤ Clinical implications
Ǥ ǡ ǡ Ǥ Ǥ Ǧ ǡ ȋǤǡʹͲͳͷȌǤ ǡ ǡ Ǥ ǡǡǦǡ to reach. At the same time, within such an ‘earned secure relationship’, dysfunctional beliefs can Ǥ ǡ Ǥ ǡ
8 Ǥ ǡ and countertransference and holds that early childhood experiences play a role in a patients’ ȋǡǤʹͲͳʹȌǤǡ ǡ ǡ Ǧǡ Ǥ ǡǡǤ ǡ Ǥ ǡ Ǥ ȋǤǡʹͲͲͷǢ ǤʹͲͳͺǢǤǡʹͲͳͻǢ Ƭ ǡʹͲͳͻȌǡ ȋƬǡʹͲͳͶȌǡ
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ȋ ǤǡʹͲͳ͵ȌǤ ȋǡƬǡʹͲͲȌǡ ǡǡ Ǥ ǡ ȋ Ȍǡ Ǥ ǡ Ǥ ǡM ȋM αͳͳǤͷͺǢȌM ȋ αͳͲͺǤͲȌ ȋ α ͳ ͳʹ͵Ǥ͵ȌǡȋʹͲͲͺȌ Ǥ Ǥ ǡ ȋƬǡʹͲͳͶȌǡ ȋ Ǧ ǤǡʹͲͳͲȌǤ Suggestions for future research
Future research should investigate whether the loneliness contributing to psychosis is ‘in the eye quantityof the beholder’ or Ǥ ǡ quali Ǥ ȋƬ ǦGraae, 2005) than actual ‘aloneness’. Furthermore, investigating loneliness in the ǡ ȋ ƬǡʹͲͳͶȌǤǡ ǡ ȋǡǡǡƬ ǡʹͲͳͺȌǤ ǡ ǡ ǡ ȋǡʹͲͳͺȌǡ ȋ±ǤǡʹͲͳȌǡ Ǥ ǡǦ ǡ Ǥ Ǧ Ǧ
ͳ Ǥ ǡ Ǧ ǡ Ǧ Ǥ
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ȋƬǡʹͲͳ͵ȌǤ ǡ Ǥ Ǥ ǡǡ ǡȋǤǡʹͲͲͶȌǡ ȋ ǤǡʹͲͳͺȌǤǡ Ǥ ǡ ǡ enhancing techniques will be of little value “…if the patient is not helped to mentalize at the time when intense emotional states are evoked in attachment relationships” (Allen, et al., 2008). In ǡ ǡǤ ǡȋ Ƭǡ ʹͲͲͻȌǡ ȋ ǤǡʹͲͳʹȌ ȋƬǡ ʹͲͲ͵ȌǤ ǡǦ ǡ Ǥ ǡǦǡ Ǥ General strengths and limitations
Ǥ ǡ Ǥ ǡ
8 ǡ ǡ ǡ ǡ Ǥ Ǥ ǡ Ǥǡ ǡ Ǥ ǡ Ǥ ǡ ȋ ǤǡʹͲͳͷȌǤ Ǥ Ǥ ȋ Ȍǡ Ǥ ǡ ǡ
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ǡ ǡǤ
Concluding remarks
The inherent “unǦunderstandability” of psychotic expe Ǥ ǡǡ ǡ Ǥ owever, we also argued that having one’s personal experiences ǡ Ǥ s, and thus improve people’s capacity to communicate with and learn from others. A Ǥ ǡ ǦǤ ǡ ǡ ǡ Ǥ ǡ ǡ Ǥ References
ǡ ǤǡƬǡǤȋʹͲͲͺȌǤ Schizophrenia research 99 Ǥ ǡ ȋͳǦMentalizing͵ȌǡͳǦͳͺͳǤ in clinical practice ǡ Ǥ Ǥǡ ǡǤǡƬǡǤǤȋʹͲͲͺȌǤ Ǥ ǡǡǤ Bartels‐Velthuis, A. A., Blijd‐HoogewysǡǤǤǡƬǡ ǤȋʹͲͳͳȌǤBetter theory‐of‐mindActa skills in ǤPsychiatrica Scandinavica, 124 ȋ͵Ȍǡͳͻ͵ǦͳͻǤ ǡǤǡƬ ǡǤȋͳͻͻͻȌǤ American journal of ǣ ǤPsychiatry, 156 ȋͳͲȌǡͳͷ͵ǦͳͷͻǤ ǡǤǡƬ ǡǤȋʹͲͲͳȌǤAmerican Journal of psychiatry, 158 ǣͳͺǦǦǤ ȋͳȌǡ͵ǦͶʹǤ
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ǡǤǡƬ ǡǤȋʹͲͲȌǤǤ Ǥ ǤThe handbook of mentalization-based treatment ƬǤ ȋǤȌǡ ȋǤͳͺͷ–ʹͲͲȌǤ ǡ ǣ Ƭ Ǥ ǡǤǡƬ ǡǤȋʹͲͲͺȌǤͺǦǦAmerican Journal of ǣPsychiatry, 16 ǦǤ ͷȋͷȌǡ͵ͳǦ͵ͺǤ ǡǤǡǡǤǡ ǡǤǡǡ Ǥǡǡ ǤǡǡǤǤǡǤǤǤƬǡǤ ȋʹͲͳͻȌǤ Psychiatric rehabilitation journal. ǣ ǦǤ
ǡǤǡǡǤǡ Ǧǡ Ǥǡ ±ǡǤǡƬǡǤȋʹͲͳͻȌǤ ǣ ǡChild Abuse & Neglect 95 Ǥ Australian andǡ NewǤ ǡǤǡZealandƬ Journal ǡ Ǥȋͳͻͻ͵ȌǤ Ǥ of Psychiatry ǡʹȋ͵Ȍǡ͵ͶǦ͵ͺǤ ǡǤǡǡǤǡǡ ǤǡǡǤǡ ǡǤǡǡǤǡǤǤǤƬǡǤ ȋʹͲͳ͵ȌǤ ǣ The British Journal of Psychiatry 203 Ǥ ǡ ȋͳȌǡͷͺǦͶǤ ǡǤǤǡƬ ǡǤ ǤȋʹͲͲͲȌǤ ‐ ‐ ǣ Clinical psychology: Science and practice 7 ǤAttachment and loss, vol. II: Separation ǡ ȋʹȌǡͳǦͳͺͺǤ ǡ Ǥȋͳͻ͵ȌǤ Ǥ ǡǡǤ
ǡǤǤǡ ǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͳͺȌǤǦ 8 ǫ Schizophrenia research 195 ǦǤ ǡ ǡͳ͵ǦʹʹǤ ǡǤǤǡƬ ǡǤȋʹͲͳͶȌǤǦ Ǥ Ǥ Ǥǡ ǤǡǤò Social cognition and metacognition in schizophrenia: Psychopathology and treatmentȋǤȌǡ approaches, ʹͶͷǦʹͷͻǤ ǡǡǤ ǡǤǤǡǡǤǤǡƬǡ ǤȋʹͲͳ͵ȌǤ ǦǡPsychological medicineǦ ǣ43 Ǧ Ǥ ǡ ȋͳʹȌǡʹͶͷǦʹͶͷǤ ǡǤǡƬǡǤǤȋʹͲͳͶȌǤ Dialogues in clinical neuroscience 16 Ǥ ǡ ȋͶȌǡͷͲͷǤ
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ǡǤǡǡǤǡǡǤǤǡǡ ǤǡǡǤǤǡƬ ǡǤǤȋʹͲͲͷȌǤSchizophrenia ȋȌ ǤResearch, 74 ȋʹǦ͵ȌǡʹͲͳǦʹͲͻǤ ǡǤǡǡǤǤǡƬǡǤȋʹͲͲͷȌǤBehavioural and Cognitive Psychotherapy33 Ǥ ǡ ȋ͵Ȍǡ͵ͷͳǦ͵ͷͻǤ ǡǤǡǡǤǡ ǡǤǤǡǡǤǡǡǤǡǡǤǡƬ ǡǤȋʹͲͳȌǤ SchizophreniaǦ Research, 175 ǣ Ǥ ȋͳǦ͵ȌǡͳͺǦͳ͵Ǥ ǡǤǡƬ ǡǤȋʹͲͳͶȌǤ ǡPersonality and mental health, 8 Ǥ ȋͳȌǡͷʹǦǤ ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǡ§ǡǤǡǡǤǤǡǦ ǡǤǡǡǤǡƬ ǡǤȋʹͲͳȌǤ Psychological medicine, 46Ǧ ǦǦ – Ǥ ȋͳȌǡ ͺǦͳͲͳǤ ǡǤǤǡǡǤǤǡƬǡǤǤȋʹͲͲȌǤ Schizophrenia bulletin 32 ǣǤ ǡ ȋͳȌǡͶͶǦ͵Ǥ ǡǤǡ ǡ Ǥǡ ǡǤǤǡͳͻͻͷǤ ǡ ǣSchizophrenia research, investigating17 “theory of mind” in people with schizophrenia. ȋͳȌǡͷǦͳ͵Ǥ ×ǦǡǤǡǡǤǡÀǡǤǡǡǤǡǦ ǡ ǤǡǡǤǤǡ ǦǡǤȋʹͲͳȌǤ Focus, 14 Ǧ Ǥ ȋ͵Ȍǡ ͵ͺǦ͵ͻͷǤ ±ǡǤǡǡ Ǥǡǡ ǤǡǦǡǤǡǡǤǡ ǡǤǡƬǡ ǤȋʹͲͳȌǤJournalǦ of Contemporary PsychotherapyǦ ǣ46 Ǥ ǡ ȋͶȌǡʹͳǦʹʹͷǤ ±ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳȌǤ ǡǡ ǤFrontiers in human neuroscience, 10 ǡͶͲǤ ±ǡǤǡƬǡǤȋʹͲͳͻȌǤThe Neurobiology-Psychotherapy -Pharmacology Intervention Triangle: The Ǥneed for common sense in 21st century mental health ǡͳͶͳǤ ǡǤǡǡǤ ǤǤǡǡǤǤǡ ǡǤǡǡǤǡǡ ǤǡǤǤǤƬǡ Ǥ ǤǤȋʹͲͳͻȌǤ ȋ ȌPsychological Medicine 49 Ǥ ǡ ȋʹȌǡ͵Ͳ͵Ǧ͵ͳ͵Ǥ
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ǡǤǤǡǡ Ǥǡ ǡǤǤƬ ǡ ǤȋʹͲͲȌǤ ǣEuropean Psychiatry, 22 ǦǤ ȋͳȌǡͳ–ͺǤ ǡǤǤǡ ǡ Ǥǡ ǡǤƬǡ ǤȋʹͲͲͻȌ Harvard ReviewǦ of ǣPsychiatry 17 Ǥ ǡ ȋͳȌǣͳ–ʹ͵Ǥ ǡǤǡǡǤǡǡǤǡƬ ǡǤȋʹͲͳͺȌǤ Personality Disorders: Theory, Research,ǣ Ǥand Treatment 9 ǡ ȋͳȌǡʹʹǤ ǡǤǡǡǤǡǡǤǡƬǡǤǤȋʹͲͳͺȌǤ Psychiatry Research, 269 Ǥ ǡͷǦ͵Ǥ ǡǤǡǡǤǡǡǤǤǤǡǡǤǤǡ ǡ Ǥǡǡ Ǥ ǤǤȋʹͲͳͲȌǤ Clinical PsychologicalǦ ǣ Review, 30 ǦǤ ǡʹͷ–͵Ǥ ǡǤǡǡǤǡǡǤǡƬǡ ǤȋʹͲͳ͵ȌǤ ǣ Clinical Ǣ Practice & Epidemiology in Mental Health, 9 Ǥ ǡʹͲʹ–ʹͲͻǤ ǡǤǤǡǡ ǤǤǡǡǤ ǤȋʹͲͲͷȌǤǦ Health Technology Assessment, 9 ȋȌ Ǥ ǡͳ–ͳͶǤ ǡǤǡǡǤǡǡǤǡ ǡǤǡǡǤǡƬǡǤȋʹͲͳͷȌǤ ǣBritish Journal of Developmental
ǤPsychology 33 8 ǡ ȋʹȌǡʹͲ͵ǦʹͳǤ ǡǤǡƬǡǤǤȋʹͲͲȌǤ Journal of clinical psychology 62 ‐ Ǥ ǡ ȋͶȌǡͶͳͳǦͶ͵ͲǤ ǡǤǡƬǡǤȋʹͲͲͻȌǤǡǦ Development and psychopathology 21 Ǥ ǡ ȋͶȌǡͳ͵ͷͷǦͳ͵ͺͳǤ ǡǤǡƬǡǤȋʹͲͳͶȌǤ Psychotherapy 51 Ǥ ǡ ȋ͵Ȍǡ͵ʹǤ ǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͳȌǤ ǣʹǤǡ Borderline personality disorder and emotion Ǥdysregulation 4 ǡ ȋͳȌǡͻǤ
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ǡǤǡǡ Ǥǡǡ ǤǡǡǤǡǡǤǡ ǡ ǤǡǤǤǤƬ ǡǤȋʹͲͳͷȌǤ ȋȌǣ ǡThe Lancet Psychiatry 2 Ǧǡ The cognitive neuropsychologyǤ of schizophreniaǡ ȋͳͳȌǡͻͷǦͻͺ͵Ǥ ǡǤǤȋͳͻͻʹȌǤ Ǥǡǣ Ǥ ǦǡǤǡǡǤǡǡǤǡǡ ǤǡǡǤǡ ǡǤǡǤǤǤƬ ǤȋʹͲͳͲȌǤ Journal of psychiatric research 44 Ǧ Ǥ ǡ ȋͷȌǡʹͻͶǦ͵ͲͳǤ ǡǤǤǡƬ ǡǤȋͳͻͻͻȌǤ ǣ British journal of clinical psychology 38 Ǥ ǡ ȋʹȌǡͳͳ͵ǦͳͷͶǤ ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͻȌǤ ǣWorld Psychiatry 18 Ǥ ǡ ȋʹȌǡͳͶǦͳͳǤ ǡǤǡǡǤǡƬ ǡ ǤȋʹͲͳͻȌǤPsychosis 11 ǣ ǦǤ ǡ ȋ͵Ȍǡʹʹ͵Ǧʹ͵Ǥ ǡǤǡ×ǡǤǡǡǤǡ ǦǡǤǡǡ ǤǡƬ ǡǤȋʹͲͳͷȌǤ Personality Disorders: Theory, ǤResearch, and Treatment 6 ǡ ȋͳȌǡͺͳǤ ǡ Ǥǡ ¡ ǡǤǡ ǡǤǡƬǡǤActa PsychiatricaȋʹͲͳʹȌǤ Scandinavica 125 Ǥ ǡ ȋʹȌǡͳͷǦͳǤ ǡǤǤǡƬǡǤǤȋʹͲͳͶȌǤ ǣ The Lancet 383 Ǧ Ǥ ǡ ȋͻͻʹͻȌǡͳǦͳͺǤ ǡǤǡ ǡǤ Ǥǡǡ Ǥǡ ǡǤǡǡǤǡƬǡǤǤȋʹͲͳͶȌǤ– ǣ The British Journal of Psychiatry 204 Ǧ Ǥ ǡ ȋͳȌǡʹͲǦ ʹͻǤ ǡǤǡǡǤǤǡƬ ǡǤ ǤȋʹͲͳͻȌǤ ǣ Psychological medicine 49 Ǥ ǡ ȋͺȌǡͳʹ͵͵Ǧͳʹ͵Ǥ ÞǡǤǤǡ ǡǤǡÞǡǤǡ ǡ ǤǡǡǤǡƬÞǡǤȋʹͲͳ͵ȌǤ ‐ Acta Psychiatrica Scandinavica 127 ǣǤ ǡ ȋͶȌǡ͵ͲͷǦ ͵ͳǤ ǡ Ǥǡǡ Ǥǡ ǡǤǡǡ ǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͳ͵ȌǤ ǣ ǡ ǡAmerican Journal of Psychiatry, 170 Ǥ ȋȌǡ͵ͶǦͶͳǤ
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ǡǤǡ ǡǤǡ ǡǤǤǡƬǡǤȋʹͲͳ͵ȌǤSchizophrenia research 150 ǣǦǤ ǡ ȋͳȌǡͳǦͳͺͶǤ ǡ ǤǡǡǤǡǡǤǡ ǡǤǡǡ ǤǡǡǤǡƬǡǤȋʹͲͲȌǤ ǣ British Medical Journal, 332 Ǥ ǡͺͳͷ–ͺʹͲǤ ǡǤǡǡǤǡ ¡¡ǡǤǡ¡ǡǤǡǡǤǡǡǤǤǡǤǤǤƬ ǤȋʹͲͲͺȌǤ Ǧ Ǧ Psychological medicineǦ 38 ͵ǦǦǤ ǡ ȋͷȌǡͺͻǦͲ͵Ǥ ǡ Ǥ ǤǡǡǤ Ǥǡ ǡǤǡƬ ǡǤȋʹͲͳʹȌǤBehavioural and Cognitive Psychotherapy ǣ Ǥ40 ǡ ȋͳȌǡͳͲͷǦͳͲͻǤ Lardinois, M., Lataster, T., Mengelers, R., Van Os, J., & Myin‐Germeys,Acta Psychiatrica I. (2011).Scandinavica, Childhood 123 trauma Ǥ ȋͳȌǡʹͺǦ ͵ͷǤ ǡǤǤǡǡǤǡǡǤǤǡ ǡǤ ǤǡƬ ǡǤȋʹͲͳͺȌǤ BMC psychology 6Ǧ ǡ ǣǦǤ ǡ ȋͳȌǡ͵ʹǤ ǡ ǤǡǡǤǡ ǡǤ ǤǡǡǤǡǡ ǤǤǡǡ ǤǤǡǤǤǤƬǡǤ ȋʹͲͳͷȌǤ The Lancet Psychiatry 2 Ǧ ǣ Ǥ ǡ ȋȌǡͶͺǦͲǤ ǡǤǡǡǤǡ ǡǤǤǡ ǡǤǤǡǡ Ǥǡ ǡ ǤǡƬǡ
ǤȋʹͲͳͶȌǤ Psychiatry research 220 8 Ǥ ǡ ȋ͵ȌǡͺʹͷǦͺ͵͵Ǥ ǡ ǤǤǡǡǤǤǡƬ ǡ Ǥ ǤȋʹͲͳ͵ȌǤ JAMA 310 ǣ Ǥ ǡ ȋȌǡͺͻǦͻͲǤ ǡǤǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡ ǡǤǡǡǤȋʹͲͳͶȌǤ ǡǫ Psychiatry Research 216 Ǥ ǡ ȋʹȌǡͳͻͺǦʹͲͷǤ ǡ ǤǤȋʹͲͳ͵ȌǤ Psihologija 46 ǣ Ǥ ǡ ȋʹȌǡͳͻ͵ǦʹͳʹǤ ǡǤǤǡǡǤǤǡǡ ǤǤǡǡǤǡǡǤǡƬǡǤȋʹͲͳʹȌǤPsychiatry Research: ǡ ǡ ǤNeuroimaging 201 ǡ ȋ͵Ȍǡʹ͵͵Ǧʹ͵ͻǤ
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ǡǤǤȋʹͲͳͲȌǤǡ ǣ Schizophrenia Research 120 Ǥ ǡ ȋͳǦ͵ȌǡͶͻǦ ͷ͵Ǥ Minding the child: Mentalization-based interventions with ǡǤǡƬǡ ǤȋǤȌǤȋʹͲͳ͵children, young people and theirȌǤ families ǤǡǡǤ ǡǤǡƬǡǤǤȋʹͲͲȌǤ ǣ Current opinion in psychiatry 20 Ǥ ǡ ȋȌǡ ͳͻǦʹͷǤ Ǧ ǡƬ ǤȋʹͲͲȌǤClinical psychologyǦ ǣ review, Ǥ ʹȋͶȌǡͶͲͻǦͶʹͶǤ
±ǡǤǡǡǤǡƬǡǤȋʹͲͳʹȌǤ ȋClinicalȌ ǣ practice and epidemiology in mental health: CP & EMH, 8 ǦǤ ǡͳͶͶǤ
ǡǤǤǡǡ Ǥǡ¡ǡǤǡǡǤǡƬǡǤȋʹͲͳȌǤ ȋ Ȍǣ Community mental health journal, 52 Ǥ ȋͺȌǡͺͻͺǦͻͲǤ
ǡ Ǥ ǤǡƬ±ǡǤȋʹͲͳͺȌǤ Ǧ ǣ Schizophrenia and CommonǦ Ǥ ×ǡ Ǥǡ ǡ Ǥǡ Sense ǡ Ǥ ǤȋǤȌǡ ǡͳͻ͵ǦʹͲǤǡǣ Ǥ ǡǤǡ ǡǤǡǡ ǤǡǡǤ ǤǡǡǤǤǡ ǡǤǡǤǤǤƬ ǡ Ǥ ȋʹͲͳͻȌǤ Journal of consulting and clinical psychologyǦ ǣ87 Ǥ ǡ ȋʹȌǡͳͷͳǤ ±ǡǤǡǡǤ ǤǡǡǤǡ ǡǤǡǡ ǤǡǡǤ ǤǡƬ ǡǤ ǤȋʹͲͳȌǤ Ǧ Schizophrenia research 189 ǦǦ Ǥ ǡ ǡͳʹǦͳͺǤ ǡ Ǥǡǡ ǤǡǡǤǤǡƬǡǤǤȋʹͲͲͷȌǤǡ Acta ǣ ǤPsychiatrica Scandinavica 112 ǡ ȋͷȌǡ͵͵ͲǦ͵ͷͲǤ ǡǤ ǤǡƬ ǡǤȋʹͲͳʹȌǤJournal of theǦ American Academy of CǦ ǣhild & Adolescent Psychiatry 51 Ǥ Technicalǡ ȋͳʹȌǡͳ͵ͲͶ adaptationsǦͳ͵ͳ͵Ǥ from MBT to Schizophrenic Psychosis. Working on the Self ǡǤȋʹͲͳͺȌǤBoundaries ǡ ǡǡǤ
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Schizophrenia Bulletin,
ǡǤǤǡƬǡ ǤȋʹͲͲ͵ȌǤ ǡ ǡǤ29 ǡͶʹ–ͶͶͶǤ ǡǤȋʹͲͳȌǤ ǣPsychoanalytic Psychology 34 Ǥ ǡ ȋͳȌǡͻǤ ǡǤǤǡǡ ǤǤǡƬǡ ǤǤ ǤȋʹͲͲͶȌǤǦǣ Ǥ ǡǤǤǡ ǡǤǤǡƬǡǤMindfulness and acceptance: Expanding the cognitive-behavioral tradition ǤȋǤȌǡ ǡͶͷ– ͷǤǡǣ Ǥ The British ǡ ǤǤǡƬJournal of PsychiatryǦ ǡǤ187ȋʹͲͲͷȌǤ ǣ ǫ ǡ ȋʹȌǡͳͲͳǦͳͲʹǤ American psychologist 65 ǡ ǤȋʹͲͳͲȌǤ Ǥ ǡ ȋʹȌǡ ͻͺǤ ǡ ǤǡƬǡǤȋʹͲͳȌǤ Psychosis 9 ǣ ǦǤ ǡ ȋͳȌǡǦͺͳǤ ǡǤǤȋʹͲͳͺȌǤ Frontiers in behavioral neuroscience 12 Ǥ ǡ ǡʹͻͶǤ ǡǤǡ ǡǤǡǡǤǡ ǡ ǤǡƬǡ ǤȋʹͲͲȌǤThe British Journal of Psychiatry 191 ǣǦǤ ǡ ȋͳȌǡͷǦͳ͵Ǥ ǡǤǡǡǤǡǡǤǡ ǡ ǤǡƬ ǡ ǤȋʹͲͳȌǤ ǣ ǫAmerican Journal of Psychiatry 174 Ǧ Ǥ ǡ ȋͳͲȌǡͻͶ͵Ǧͻͷ͵Ǥ ǡǤǡǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͲȌǤActa
ǣ ǤPsychiatrica Scandinavica, 116 8 ǡͳͲͷ–ͳͳʹǤ ǡǤǡǡǤǡǡǤǡƬ ÚǡǤȋʹͲͳȌǤ Psychopathology 49 Ǥ ǡ ȋͶȌǡʹ͵ǦʹͶǤ ǡ ǤǤǡǡǤ ǤǡǡǤǡ ǡ ǤǡǡǤǡƬǡǤȋʹͲͳʹȌǤǦ ǣPsychotherapy 49 Ǧ Ǥ ǡ ȋ͵ȌǡʹǤ ǡǤǤǡ ǡǤǡ ǡ ǤǤǡǡǤǤǡǡ Ǥ ǤǤǡǡǤ ǤǡǤǤǤƬ ǡǤȋʹͲͳȌǤ PsychiatryǦ research 238 Ǥ ǡ ǡͳͶǦʹ͵Ǥ ǡǤǤǡǡǤǤǡǡǤǤǡǡǤǡ ǡǤǡǡǤǡ Ƭ ǡǤȋʹͲͳͷȌǤ
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JAMA psychiatry 72 ǣ Ǥ ǡ ȋ͵ȌǡʹͷͻǦʹǤ ǡǤǡǡǤ Ǥǡǡ ǤǡǡǤǡ ǡ ǤǤǡǡǤǤǡǤǤǤƬǡǤ ǤȋʹͲͳʹȌǤ Schizophrenia bulletin 38 ǣ Ǥ ǡ ȋȌǡͳͳͺͲǦ ͳͳͺͺǤ ǡǤǡǡǤǡƬ ǡ ǤȋʹͲͳȌǤ ǣSchizophrenia research, Ǥ ͺͺǦͻ͵Ǥ ǡǤǡǡ ǤǡǡǤǡǡǤǡǡǤǤǤǡƬ ǡǤ ȋʹͲͳȌǤ ǣPsychological medicine 46 Ǧ Ǥ ǡ ȋͳȌǡͶǦͷǤ ǡǤ ǤǡƬ ǡǤǤȋʹͲͳͶȌǤǣBrain imaging and Ǧ behavior, 8 Ǧ Ǥ ȋͳȌǡʹͶǦ͵ͺǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳʹȌǤ ǣSchizophreniaǦ bulletin 38 Ǧ ǡ Ǧ Ǧ Ǥ ǡ ȋͶȌǡ ͳǦͳǤ ǡ Ǥ ǤǡǡǤǡ ǡǤǤǡǡǤ ǤǤǡǦǡǤ ǤǤǡƬ ǡ ǤǤȋʹͲʹͲȌǤǦ ǣPsychological Medicine. Ǧ ǡǦ ǡ Ǥ ǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͲͺȌǤSchizophrenia ǣ ǡ ǡ Ǥbulletin 34 ǡ ȋ͵Ȍǡͷʹ͵Ǧͷ͵Ǥ
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Addendum
SUMMARY IN DUTCH
VALORIZATION
LIST OF PUBLICATIONS AND INVITED LECTURES
ACKNOWLEDGEMENTS
CURRICULUM VITAE
Appendices
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Nederlandse samenvatting
Inleiding
´ Ǥ Ǥ ǡ onjuiste interpretaties van de werkelijkheid, ook wel ‘wanen’ genoemd, en de perceptie van dingen die niet echt aanwezig zijn, ‘hallucinaties’ genoemd. Ongeveer 6% van de ±± ǡ Ǥ ´ Ǥ ǡ ǡ̵Ǧ ̵ȋȌǡ ǦͷǦ ´ ǡ Ǧ ǡ Ǥ ´ ȋ ǡʹͲͳ͵Ȍǡ ̵̵Ǥ Ǥ Ǥ ǡ ǡ´ ǡ Ǥ ǡ ȋǤ ǡ ǡƬ ǡʹͲͳͻȌǡ Ǥ ȋǤǡʹͲͲ͵Ȍǡ ´ ȋǤ ǤǡʹͲͳ͵ȌǤ ǡͳͲͲ ´ȋ ǡ ƬǡʹͲͳͷȌǤǡ
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ȋǡƬǡʹͲͲȌ ȋ Ǧ ǤǡʹͲͳͲȌǡ mogelijk ǡ ǡ ȋǤǡʹͲͳȌǤ ǡ –ȋǡǡǡƬǤʹͲͳʹȌ ȋǡǡ Ƭ ǡʹͲͳ͵Ǣǡ ǡǡƬǡʹͲͳȌ– Ǥ Ǧ ǡ ȋǤ Ǥǡ ʹͲͲȌǤ ȋ Ƭ ǡʹͲͳͻ Ȍǡ±±ǡ ȋ ǤǡʹͲͳͻȌǤ Mentaliseren en sociaal functioneren
ociaal cognitief of ‘mentaliserend’ vermogen een ´ȋǤ ǡ ǡǡƬǡʹͲͳͳȌǤ ǡǡ Ǥ van iemands binnenwereld. Vervolgens kan zo’n voorstelling gebruikt worden om het gedrag ȋȌǡ Ǥ ǡ
Ǥ A ´ǡ ȋǡǡ ǡǡ ǡƬ ǡʹͲͲȌǡȋ̵ ǡƬǡʹͲͳͶȌǡ ȋǤǡʹͲͲȌ ȋ±ǡʹͲͲȌǤ ±± Ǥ´ ȋǤǡʹͲͳʹȌǤ ȋǡǡ ǡǡƬǡʹͲͳ͵ǢǤǡ ʹͲͳʹǢƬ ǡʹͲͲǢǤǡʹͲͳͷȌǤ‘’
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Ǥ Ǥ ǡ ǡ Ǥ ȋ±ƬǡʹͲͳͻȌǤ Ǧ ȋ ǡͳͻͻʹȌǤ ǡ ǡ ǡ ȋ ǡͳͻͻʹȌǤ Doelen van dit proefschrift ǡ Ǥ ȋȌ ´Ǥ ǤDoel I: Schetsen hoe mentalisatietheorie kan bijdragen aan het begrijpen en behandelen van NAPS. Ǥ ͳ Ǥ Ǥ ǡ ǡ ǡ ǡ een gebrek aan ‘epistemisch vertrouwen’ en verminderd mentaliseren met elkaar samenhangen Ǥ ´Ǥ Doel II: Het toetsen van verschillende hypothesen die de relatie tussen kindermishandeling en de ernst van symptomen bij volwassen patiënten met NAPS kunnen verklaren.
ǡ Ǥ In hoofdstuk drie onderzochten we of een verhoogde ‘stressreactiviteit’ het verband ǡ
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ȋǦ ƬǡʹͲͲǢǡǡǦǡ Ƭ ǡʹͲͳȌǤ Ǥ ǡ ȋ ǡǡƬǦ ǡʹͲͲǢ ×ǦǤǡʹͲͳǢǤǡʹͲͳͺǢǡǡǡǡƬ Ǧ ǡʹͲͳ͵ǢǤǡʹͲͳȌǤ ȋ ǤǡʹͲͲǢ×ǦǡʹͲͳǢǤǡʹͲͳͺǡǤ ʹͲͳͳȌǡ ǦǤ ǣͳȌ ´ǢʹȌ ͵Ȍ Ǧ ǡǤ Ǥ Ǥ ´ǤDoel III: Testen of Mentaliseren Bevorderende Therapie voor psychotische stoornis (MBTp)
een effectieve aanvulling is op de gebruikelijke behandeling met betrekking tot sociaal A disfunctioneren en beperkt mentaliserend vermogen.
Treatment as Usual ȋȌ ȋȌǤ Belangrijkste meetinstrumenten van het proefschrift Sociaal functioneren. Social Functioning Scale
ȋ ȌǡǦȋ ǡǡ ǡƬǡͳͻͻͲȌ ǡǣ ǡ ǡ ǡ
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ǡ ǡ Ǥ ȋ Ȍ Ǥ ȋ ǤǡͳͻͻͲȌǤ Ǥ Meting van mentaliserend vermogen
Ǥ Ǥ ǡ ǤǦ Ǥ ȋ ǡʹͲͲͺǢ Ƭ ǡ ʹͲͳͻȌǤ ǡ Ǥ Hinting Task ǡ ȋ Ǣ ǡ ǡƬ ǡ1995) als een van de weinige instrumenten ‘goed genoeg’ ȋǤǡʹͲͳ͵ȌǤ ǡ ÃǤ Ǥ ǡ Ǥǣ Ǥ ertellen over een aantal zakelijke ontwikkelingen. Peter onderbreekt Annet met een: “Tjonge, jonge, dat was me een lange zware reis”. Wat bedoelde Peter werkelijk toen hij dit zei? ȋ ǡ ǡƬ ǡͳͻͻͷȌǤ
Theory of Mind ǡ ook wel ‘ ’ genoemd. In feite gaat het hier om een cognitief, op anderen ´ Ǥ Ǧǡ ǡ
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´ ȋ ǤǡʹͲͳ͵ȌǤ ǡ leiden tot ‘plafondeffecten’ (bijv. Roberts & Penn,Theory 2009). of MindDe HT wordt gescoord op een 20Ǧ ǡ Ǥ Social Cognition and Object-Relations Scale ȋȌǡ ´Ǥ ǦȋǢǡͳͻͶ͵ȌǤ ‘projectieve’ taak die bestaat uit zwartǦ̵ǡ Ǥ Ǥ ǡ ǡ Ǥ ÃǤ´ Ǥ ontleed worden in welke mate patiënten een ‘psychoǦlogisch’ verhaal kunnen vertellen over de Ǥ ǣ gedrag te kunnen geven (ook wel ‘begrip van sociale causaliteit genoemd’); het vermogen ȋ ‘complexiteit van representaties’); de mate waarin sociale interactie als goedaardig gezien wordt (de ‘affectǦelaties’) en in hoeverre er sprake is van morele standaarden waarbij
de ander gezien wordt als een doel op zich en niet als een middel (het ‘vermogen tot emotioneel A investeren’). Deze vier dimensies van mentaliserend vermogen werden gescoord op een Ǧ ǡ Ǥ ȋǤ ǤǡʹͲͳ͵Ǣ ǡƬ ʹͲͳͻȌǤ Ǥ ȋǡʹͲͲͶȌ ȋ ǡ Ƭ ǡʹͲͲͳȌȋ Ǥǡ ʹͲͲͳȌȋǡʹͲͲͶȌǤ ǡ ǡ ȋʹͲͳʹȌ
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ǡ ȋ Ȍ ȋ Ǧ ȌǤ Mishandeling in de kindertijd Childhood Experience of Care and Abuse
ȋǢ ǡƬ ǡͳͻͻͶȌ ǡǦ ͲǦͳǤ ǡǡ Ǥ Ǥ Ǥ ȋ ȌǤ ǡǡǤ Ǥ ǣͲȋȌǡͳȋǣ±± Ȍǡʹȋ ǣǡȌǡ͵ȋǣ ȌͶȋǣȌǤ ǣͲȋȌǡͳȋȌǡʹȋȌ͵ȋȌǡ ǡ ͶȋȌ Ǥ ǡͲͷʹǡ Ǥ ȋ ǡƬ ǡͳͻͻͶȌǤ Klinische symptomen en ziekte-inzicht Positive and Negative Syndrome Scale
ȋǢǡ ǡƬǡͳͻͺȌ Ǧ Ǥ Ǧ ǡȋƬǡͳͻͻͶȌǤ ǡǡǡǦ in kaart te brengen. In dit instrument bevatten de dimensies ‘positieve symptomen’ en ‘negatieve symptomen’ elk zeven items (zie Weijers et al. 2016 voor meer informatie). Angst, Ǧ ±±Ǥ ǡͳ
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Ǥ ȋǡƬ ǡʹͲͲͲȌǤ Experience Sampling: psychotische ervaringen, negatief en positief affect, eenzaamheid, middelengebruik, verscheidene types stress en stressreactiviteit.
Experience Sampling Method ǡ ‘ ’ (ESM). Gevoelens en psychiatrische symptomen zoals ǡǡ ǡ Ǥ ǡ̵̵ Ǥǡ´ Ǥ ȋȌǤ Ǥ ȋǡǡƬǡʹͲͲʹǢǤǡʹͲͲǢ ǤǡʹͲͳͳȌǤ ǡ Ǥ komen in dit proefschrift. Alle vragen of stelling, voortaan ‘items’ genoemd, werden gemeten op ȋͳαǡαPsychotische ervaringen. ȌǡǤ ǣ̵
̵ǡ̵ ̵ǡ̵ ̵ǡ A ̵ ̵ǡ̵ Ã ̵ǡ̵ ̵̵ ̵Ǥ Depressieve en angstige Ǥ gevoelens. Ǥ ̵ ̵̵ ̵ǤEenzaamheid Ǥ̵ ̵ǤMiddelengebruik. ǡǣȋͳȌ ÃǡȋʹȌ ǡȋ͵Ȍ ǡȋͶȌ ǡȋͷȌ ǡȋȌǡȋȌǤ
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Sociale stress.
Ǥ ǣ̵ ̵̵ Activiteit-gerelateerde̵ȋ ȌǤ stress. Ǧ Ǥ ȋ̵ ̵Ȍǡ ȋ̵ ̵Ȍǡ ȋ̵ ̵ȌǤ Gebeurtenis-gerelateerde stress. Ǧ Ǥ Ǧ Ǥ NegatiefǦǤ affect. ǣ̵ ̵ǡ̵ ̵ǡ̵ ̵ǡ̵ Ã̵ǡ̵ ̵ǡ̵ ̵̵ ̵ǤPositief affect. ǣ̵ ̵ǡ̵ ̵ǡ̵ ̵ǡ̵ Stressreactiviteit.̵̵ ̵Ǥ ȋ ǦǡǦ Ȍ Ǥ Bevindingen Deel I, Hoofdstuk 2.
ʹǡ Ǧ ȋǤ ƬǡʹͲͳͶȌǡ Ǥ ÃǤ ǡ ǡ
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Ǥ ǡ Ǥ ǡ Ãǡzijn, ervaart Ǥ ǡ Ǥ Ǥ Ǥ ´Ǥ Als ‘hoger cognitief proces’ wordt mentaliseren ondermijnd doorǤ Ǥ ǡ ǡ Ǥ Ǥ Ǥ Ǥ –´– Ǥ ȋ
ȌǤ A ǡ ȋǡʹͲͳͷȌǤ Ten slotte hebben we betoogd dat een gebrek aan ‘epistemisch vertrouwen’ – ǡ ȋ ǡǡƬǡʹͲͳȌ– sociaal leervermogen en interpersoonlijke betekenisgeving. Fonagy en collega’s (2017) ǡ Ǥ ǡ´ ǡǡ soms aangeduid als ‘epistemische hypervigilantie’. Zulk wantrouwen snijdt mensen af va ǡ
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(2014). Daardoor ontwikkelen zij een ‘rigiditeit’ ten opzichte van het perspectief van anderen. ǡ Ǥ ǡ ȋƬ±ǡʹͲͳͺȌǤ Deel II, Hoofdstuk 3.
ǡȋǤǡ Lataster, Mengelers, Van Os, & Myin‐Germeys, ʹͲͳͳȌǡ Ǥ ȋǤǤǡʹͲͳͳǢǦǤǡʹͲͳͺȌ´ ǡ Ǥ Ǥ Ǥ ǦǤ ȋȌǤ Ǥ Deel II, Hoofdstuk 4.
´ ÃǤ Ǥ ȋ ǡʹͲͳ͵ǢǡǡǡƬ ǡʹͲͳ͵Ȍ ȋǤǡ ʹͲͳʹȌǤ ȋSocial ǡ Defeat ǡǡƬ ǡʹͲͳȌ en biedt verdere ondersteuning voor de ‘ ’ theorie van psychoseǦǡ
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ǦȋǡǡǡƬǦ ǡʹͲͳ͵ȌǤ ȋƬ ǡʹͲͳͷȌ ȋ ǡ ǡǡ ǡƬ ǡʹͲͳǢ òǡǡǡǡƬǡʹͲͳͶȌǤ Deel II, Hoofdstuk 5.
Ǥ ´ ǡǤ ǡ Ǥ ͶͲΨ Ǥ Deel III, Hoofdstuk 6.
ȋȌǤ Ǥ ǡ Ǥ treatment as usual
ǣ A ȋȌ ȋȌǫ Ǥ Participanten. ´ ȋǦ Ǧ ǢǡʹͲͲͲȌǡ ǡ ȋʹͻͷǤȌǡȋʹͻǤͳȌǡ ȋʹͻͺǤͺȌ ȋʹͻͺǤͻȌǤ ǣǦ ǡǡͳͲǢͳͺͷͷ Ǥ ǣȀǢ Ǣ ´ȋ
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´Ǥ´ Randomisatie.ǦȌǤ Ǧ ȋǦ Ȍ ȋȌǡ Ǥ ´ǡ Ǥ´ Ǥǡ Ǥ ǡ Ǥ Ú Treatment as Usual ȋȌǦ Ǧ Ǥ ǡ Ǥ Therapie.
TAU. ´ Ǧ Ǥ´ Flexible ȋǤʹͲͳʹȌAssertive Community Treatment’ behandelteams werkten volgens het zogenaamde ‘ ȋ ȌǦô ǡ Ǥ Ǧ ǡ ǡ Ǧ ǡ ǡ ȋ ȌǤ Ǧ ´ ǡ ǡ Individual Placement and Support (IPS) ǡ Ǧ ´ ǦTAU plu MBT. Ǥ ´Ǧ ǡǤ ǦȋƬ ǡʹͲͲȌ Ǥ Ǧ gekenmerkt door de ‘niet wetende houding’ waarbij de therapeut actief vragen stelt en een ´ Ǥ´
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ǡ ´Ǥ ´Ǥ ǡ´ Ǥǡ ǡ Ǥ ´ ǡǤ ´ ǡȋȌǤ Interventies. Ǥ Ǧǡǡ Ǥ ´Ǥ ´Ǥ ǡǡ ´Ǥ ´ Ǥ ´ǡ´Ãǡ doen. Dit leidt vervolgens tot de volgende fase, die ook wel ‘gementaliseerde emotionaliteit’ Ǥ ´ ǡǦǦǤ ǡ ´ǡ
ǡ Ǥ A ´Ǥ ´ ÃǤDuur en frequentie. ǣͳͺǤ Ǥ Ǧ ´ Ǥ ǡ ͳǡ Ǥ
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Groepstherapie.
´ ǡ Ǥ ǡǤ ´±±Ǧ Ǧ ǤIndividuele therapie. ´Ǥ Metingen. Ǥ ʹǤȋͲȌǤ ǡǡǤͳͺ ȋ ´ȌʹͶȋ ´ȌǤ ǡ ǡȋͲȌ ȋʹȌ ȋ͵ȌǤ Deel III, Hoofdstuk 7.
´ Ǧ Ǧ Ǥ ´ Ǥ Ǧ ´ ǡ Ǧ Ǥ ǡ ȋǤǡǡǡƬǡʹͲͳ͵Ȍǡ ȋǡǡǡǡƬǡʹͲͲȌǤ ǡ ȋ ǡ ¡ ǡ ƬǡʹͲͳʹǢ ǤǡʹͲͳͻȌǤ ȋαȌ ȋαͳȌǡ Ǧ Ǥ ǤǦ Ǥ
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ȋʹͲͲͳȌ ´ǡ ´ ȋƬ ǡʹͲͲͺȌǤ ǡ´ Ǥ ǡ ǦǦ ȋƬ ǡʹͲͳʹǢǡǡǡƬ ǡ ʹͲͳͺȌǡ´Ǧ Ǥ´ ǡ dimensies ‘begrip van sociale causaliteit’ en ‘complexiteit van representaties’ van de SCORS, en Ǧ ǤǦ Ǥ Ǧ´ ǡȋ ǤʹͲͳͶȌǤ ȋ Ƭ ǡͳͻͻ͵Ǣ ǡǡ ǡƬǡʹͲͳͲȌǤ ͷ ȋ Ƭ ǡͳͻͻ͵ȌÃ ȋǡǡƬ ǡʹͲͳ͵ȌǤ
ǡ ȋǡ ǡǡ A ǡƬǡʹͲͳͳȌ ȋ ǤʹͲͳͶȌǤ ȋ ǡ ǡ ǡƬǡʹͲͳͲȌǤ ´ Ǥ ȋȌǢ Ǧ ȋȌǢǡ ǡ ȋȌǢǡ ǡȋȌǤ ´
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Ǥ ȋȌ´ȋČešková, Přikryl, Kašpárek, & Ondrušova, ʹͲͲͷǢǤʹͲͳͺȌǤ recruitment bias ǡ´Ǥ ´Ǥ ʹͲΨ ´ ǡ ´ Ǥ Implicaties voor de klinische praktijk
Ǥ ǡ Ǥ ´ Ǥ ´Ǥ ǡ Ǥ ǡ ǡǦ Ǥ ȋǤǡʹͲͲͷǢǡǡ ǡ ǡƬ ǡʹͲͳͺǢ Ƭ ǡʹͲͳͻȌǤ ȋǡƬǡʹͲͲȌǡ ǡǡ Ǥ ´ ȋȌǡ Ǥ ǡ ´Ǥ ´ ǡ ȋαͳͳǤͷͺǢ
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Ȍ ´ȋαͳͲͺǤͲȌ ȋαͳʹ͵Ǥ͵ȌǡȋʹͲͲͺȌǤ ´ Ã Maatschappelijke implicaties en toekomstig onderzoek
ǡͷͳͲͲͲ ȋǦòǡǡƬǡʹͲͳͺȌǤǡ ȋd Nations Population Division), wereldwijd naar schatting zo’n ͷͺ Ǥ ´ ǡ ´ ǡ´ǡȋǡ Ƭ ǡʹͲͲͺȌǤ Ǥ ȋ ǡ ƬǡʹͲͳͻǢǡǡǡ ǡ Ƭ ǡʹͲͳͺȌǤ Ǥevidence based ǡ Ǥ Ãǡ ǡ
´ȋǡʹͲͳͺȌǡ A Ãȋ±ǤǡʹͲͳȌǤ ǡ ǡ ȋǡǡƬʹͲͲͶȌ ȋ ǤǡʹͲͳͺȌǡ Ǥ Ǥ ´ǡ ´Ǥ
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Algemene sterke punten en beperkingen
Ǥ Ǥ Ǥ Ǥ ´ Ǥ Ǥ ȋ ǤǡʹͲͳͷȌǤ Ǥǡ Ǥ ȋȌǡ ÃǤ steekproef, de aanwezigheid van zogenaamde ‘type 1’ fouten. Met elke toetsing be ͷΨ ǡ Ǥ Ǧ Ǥǡ ǡ ´ǡǤ Referenties
ǡ ǤǡƬǡǤȋʹͲͲͺȌǤ Schizophrenia research 99 Ǥ ǡ ȋͳǦ͵ȌǡͳǦͳͺͳǤ ǡǤǡƬ ǡǤȋʹͲͲͳȌǤAmerican ǣͳͺJournal of psychiatry, 158 ǦǦǤ ȋͳȌǡ͵MentalisationǦͶʹǤ based treatment: a practical guide. ǡǤǡƬ ǡǤȋʹͲͲȌǤ ǣ Ǥ ǡǤǡƬ ǡǤȋʹͲͲͺȌǤͺǦǦAmerican Journal of ǣPsychiatry, 165 ǦǤ ȋͷȌǡ͵ͳǦ͵ͺǤ
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ǡǤǡǡǤǡ ǡǤǡǡ Ǥǡǡ ǤǡǡǤǤǡǤǤǤƬǡǤ ȋʹͲͳͻȌǤ Psychiatric rehabilitation ǣ journal. ǦǤ
ǡǤǡǡ ǤǤǡƬ ǡǤǤȋͳͻͻͶȌǤ ȋJournal of Child Psychology and Psychiatry, 35 Ȍǣ Ǥ ȋͺȌǡ ͳͶͳͻǦͳͶ͵ͷǤ ǡǤǡǡ Ǥǡ ǡǤǡǡǤǡƬǡǤȋͳͻͻͲȌǤ Ǥ The British Journal of ǤPsychiatry, 157 ȋȌǡͺͷ͵ǦͺͷͻǤ Australian and New ǡǤǡƬ ǡ Ǥȋͳͻͻ͵ȌǤ ǤZealand Journal of Psychiatry ǡʹȋ͵Ȍǡ͵ͶǦ͵ͺǤ ǡǤǡǡǤǡǡ ǤǡǡǤǡ ǡǤǡǡǤǡǤǤǤƬǡǤ ȋʹͲͳ͵ȌǤ ǣ The British Journal of Psychiatry 203 Ǥ ǡ ȋͳȌǡͷͺǦͶǤ ǡ Ǥȋͳͻ͵ȌǤ ǡǤ ǣǤǡǣ Ǥ ǡǤǡƬ ǡǤȋʹͲͳͷȌǤ Psychiatry research, 226 Ǧ Ǥ ȋͳȌǡ͵Ǧ͵ͺʹǤ ǡǤǤǡƬ ǡǤȋʹͲͳͶȌǤǦ Ǥ Ǥ Ǥǡ ǤǡǤòSocial cognition and metacognition in schizophrenia: Psychopathology and treatmentȋǤȌǡ approaches ǡʹͶͷǦʹͷͻǤǡǣ Ǥ ǡ Ǥǡ̵ǡǤǡǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͲȌǤ
Schizophrenia ǣ Research 89 ǫ A ǡ ȋͳǦ͵ȌǡʹͺǦʹͻʹǤ Češková, E., Přikryl, R., Kašpárek, T., & Ondrušova, M. (2005). PsychopathologyNeuropsychiatric and treatment Disease and Treatment 1 Ǧ Ǥ ǡ ȋʹȌǡͳͻǤ ǡǤǡ ǡ ǤǡƬ ǡǤǤȋͳͻͻͷȌǤ ǡ Schizophrenia inference:research, 17 investigating “theory of mind” in people with schizophrenia. ȋͳȌǡͷǦͳ͵Ǥ ǡǤǤǡǡǤǤǡƬǡǤǤȋʹͲͲȌǤ Schizophrenia bulletin, 32 ǣǤ ȋͳȌǡͶͶǦ͵Ǥ ×ǦǡǤǡǡǤǡÀǡǤǡǡǤǡǦ ǡ ǤǡǡǤǤǡƬ ǦǡǤȋʹͲͳȌǤ Ǧ
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. Focus, 14
ȋ͵Ȍǡ ͵ͺǦ͵ͻͷǤ ǡǤǡǡǤ ǤǤǡǡǤǤǡ ǡǤǡǡǤǡǡ ǤǡǤǤǤƬǡ Ǥ ǤǤȋʹͲͳͻȌǤ ȋ ȌPsychological Medicine 49 Ǥ ǡ ȋʹȌǡ͵Ͳ͵Ǧ͵ͳ͵Ǥ ǡǤǡǡǤǡǡǤǡƬ ǡǤȋʹͲͳͺȌǤ ǣPersonality Disorders: Theory, Research, Ǥand Treatment 9 ǡ ȋͳȌǡʹʹǤ ±ǡǤǡǡ Ǥǡǡ ǤǡǦǡǤǡǡǤǡ ǡǤǡƬǡ ǤȋʹͲͳȌǤJournalǦ of Contemporary Psychotherapy,Ǧ ǣ 4 Ǥ ȋͶȌǡʹͳǦʹʹͷǤ ±ǡǤǡƬǡǤȋʹͲͳͻȌǤ The Neurobiology-Psychotherapy-Pharmacology Intervention Triangle: The Ǥneed for common sense in 21st century mental health ǡͳͶͳǤ ǡǤǡǡǤǡƬǡ ǤȋʹͲͲʹȌǤSocial psychiatry and psychiatric epidemiology, 37 Ǥ ȋ͵ȌǡͻǦͳͲͶǤ ǡǤǡǡǤǡǡǤǡƬǡ ǤȋʹͲͳ͵ȌǤ ǣ ǢǤClinical Practice & Epidemiology in Mental Health, 9 ǡʹͲʹ–ʹͲͻǤ ǡǤǡǡǤǤǡEarlyǡǤ ǤǡƬǡǤǤȋʹͲͳʹȌǤ intervention in psychiatry, 6(4) first‐episode psychosis. ǡͶǦͶͺͲǤ ǡ ǤǦǤǡǡ ǤǡǡǤ ǤǡƬǦ ǡ ǤȋʹͲͲȌǤ Journal of psychosomatic research, 61 Ǥ ȋʹȌǡʹʹͻǦʹ͵Ǥ ǡǤ ǤǡǡǤǤǡǡǤǡǡǤǤǡ ǡǤǡ ǡǤǤǡǤǤǤƬ ǡǤ ȋʹͲͲͺȌǤ ǣ ǡSchizophrenia bulletin, 34 ǡ Ǥ ȋȌǡͳʹͳͳǦͳʹʹͲǤ ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͷȌǤ Ǥ ǡͳȋͳͲȌǡʹͲǤ ǡǤǡƬǡǤȋʹͲͳͶȌǤPsychotherapy, 51 Ǥ ȋ͵Ȍǡ͵ʹǤ ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͻȌǤ ǣWorld Psychiatry 18 Ǥ ǡ ȋʹȌǡͳͶǦͳͳǤ ǡǤǤ Ǥǡ ǡǤǡǡǤǤǡǡ ǤǡƬǡǤȋʹͲͳͳȌǤ ǣNeuroscience & Biobehavioral Reviews 35 ǦǤ ǡ ȋ͵Ȍǡͷ͵ǦͷͺͺǤ
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ǡǤǡƬǡǤȋʹͲͳͶȌǤ Psychotherapy 51 Ǥ ǡ ȋ͵Ȍǡ͵ʹǤ ǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͳȌǤ ǣͳƬʹǤǡ Borderline personality disorder and Ǥemotion dysregulation, 4 The cognitiveȋͳȌǡͻǤ neuropsychology of schizophrenia. ǡǤǤȋͳͻͻʹȌǤ ǡǣ Ǥ ǦǡǤǡǡǤǡǡǤǡǡ ǤǡǡǤǡ ǡǤǡǤǤǤƬ ǤȋʹͲͳͲȌǤ Journal of psychiatric research 44 Ǧ Ǥ ǡ ȋͷȌǡʹͻͶǦ͵ͲͳǤ ǡǤǡ ǡǤǡƬ ǡ ǤȋʹͲͲͳȌǤ Journal of Personality ǤAssessment, 77 ȋ͵ȌǡͶͲͺ–ͶͳͻǤ ǡǤǡ×ǡǤǡǡǤǡ ǦǡǤǡǡ ǤǡƬ ǡǤȋʹͲͳͷȌǤ Personality Disorders: Theory, ǤResearch, and Treatment 6 ǡ ȋͳȌǡͺͳǤ ǡ Ǥǡ ¡ ǡǤǡ ǡǤǡƬǡActaǤȋʹͲͳʹȌǤ Psychiatrica Scandinavica 125 Ǥ ǡ ȋʹȌǡͳͷǦͳǤ ǡǤǤǡǡǤǡǡǤǡǡǤǤǡǡǤǤǡ ǡǤ Ǥǡ ǡǤ ǤȋʹͲͲȌǤ Psychiatry Research, 149, Ǧ Ǥ ͳ–ͺͲǤ ǡǤǤǡƬ ǡǤ ǤȋʹͲͳͻȌǤ ǣSchizophrenia research, 203
Ǥ ǡ͵ǦͳͳǤ A ǡǤǤǡƬǡǤǤȋʹͲͳͶȌǤ ǣ The Lancet 383 Ǧ Ǥ ǡ ȋͻͻʹͻȌǡͳǦͳͺǤ ǡǤǤǡ ǡǤǤǡǡǤǤǡ ǡǤǡƬ ǡǤǤȋʹͲͳȌǤCognitive Therapy and Research, ǣǤ ͳǦͳͳǤ ǡǤǤǡ ǡǤǡǡǤǤȋͳͻͺȌǤ ȋȌSchizophrenia bulletin, 13 Ǥ ȋʹȌǡʹͳǦʹǤ ǡ Ǥǡǡ Ǥǡ ǡǤǡǡ ǤǡǡǤǡǡǤǡǤǤǤƬǡǤȋʹͲͳ͵ȌǤ American Journal ǣ ǡ ǡ of Psychiatry, 170 Ǥ ȋȌǡ͵ͶǦͶͳǤ
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ǡǤȋʹͲͳͷȌǤǣ Personality Disorders: Theory, Research, and Treatment 6 Ǥ ǡ ȋͶȌǡ͵ͷǤ ǡǤǡǡǤǡ ǡǤǡǡ ǤǡǡǤǡƬǡǤȋʹͲͲȌǤ ȋ ȌǣJournal of psychiatric research, 40 Ǥ ȋ͵ȌǡʹʹͳǦʹ͵ͲǤ ǡǤǡǡǤǡǡǤǡǡ ǤǡƬActa PsychiatricaǦ ǡ Ǥȋ Scandinavica,ʹͲͳͳȌǤ 123 Ǥ ȋͳȌǡʹͺǦ ͵ͷǤ ǡǤǤǡǡǤǡǡǤǤǡ ǡǤ ǤǡƬ ǡǤȋʹͲͳͺȌǤ BMC psychology 6Ǧ ǡ ǣǦǤ ǡ ȋͳȌǡ͵ʹǤ ǡǤǤǡ ǡǤǡ ǡ ǤǤǡǡǤǡ Ǧǡ Ǥǡ ǡ Ǥ ǤǡƬǡǤ Ǥ ȋʹͲͳȌǤ ǣExpert Review of Neurotherapeutics, 17(11) Ǥ ǡͳͳͳǦͳͳ͵ͲǤ ǡ ǤǤǡǡǤǤǡƬ ǡ Ǥ ǤȋʹͲͳ͵ȌǤ JAMA 310 ǣ Ǥ ǡ ȋȌǡͺͻǦͻͲǤ ǡǤǤǡǡǤǡǡǤǡǡǤǡǡǤǤǡ ǡǤǡǡǤȋʹͲͳͶȌǤ ǡǫ Psychiatry Research 216 Ǥ ǡ ȋʹȌǡͳͻͺǦʹͲͷǤ Ǥǡ Ǥǡ ǤǡǤȋʹͲͳʹȌǤǤ ƬHandbook of mentalizing in mental health practice, ȋʹͲͳʹȌǤ Ͷ͵–ͷǤǡ ǣ Ǥ The global burden of disease: 2004 update. ǡǤǡ ǡǤǤǡƬǡ ǤǤȋʹͲͲͺǤȌ ǣ Ǥ ǡǤǤǡǡǤǤǡƬ ǡǤǤȋʹͲͳͻȌǤ —Ǥ ǡͳǦͳͲǤǦ ǡƬ ǤȋʹͲͲȌǤClinical psychologyǦ review, 2 ǣ Ǥ ȋͶȌǡͶͲͻǦ ͶʹͶǤ ǡǤǤȋʹͲͳͲȌǤǡ ǣ Schizophrenia Research 120 Ǥ ǡ ȋͳǦ͵ȌǡͶͻǦ ͷ͵Ǥ ǡǤǦǤǡƬ ǡǤȋʹͲͳ͵ȌǤ Ǥ Advances in life course research, 18 Ǥ ȋ͵ȌǡʹͳʹǦʹʹʹǤ ǡ Ǥ ǤȋʹͲͲͶȌǤ ȋȌ ǣ
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Comprehensive handbook of psychological assessment,
Ǥ2, ͵ͳͷǦ͵ͶʹǤ ǡǤǤǤǡǡǤǡǡǤǡSchizophrenia Ƭbulletin. ǡǤȋʹͲͳȌǤ ǣ Ǧ Ǥ Ǧòǡ Ǥǡ ǡ Ǥǡ Ƭ ǡ Ǥ ȋʹͲͳͺȌǤ Ǥ ǦǤǡ ͳ͵ȋͶȌǤ ǡ Ǥǡ Ƭ ǡ Ǥ ȋʹͲͲȌǤ ǣSchizophrenia bulletin 33 ǣ — Ǥ ǡ ȋͳȌǡ͵ǦͳͲǤ ǡ ǤǡǡǤǡǡ ǤǡƬ ǡ ǤǤȋʹͲͳ͵ȌǤ ǣ Psychosis, 5 Ǥ ThematicȋͳȌǡ͵ ApperceptǦͶǤion Test. ǡ ǤǤȋͳͻͶ͵ȌǤ ǡǣ Ǥ Ǧ ǡƬ ǤȋʹͲͲȌǤClinical psychologyǦ ǣ review, Ǥ ʹȋͶȌǡͶͲͻǦͶʹͶǤ
±ǡǤǡǡǤǡƬǡǤȋʹͲͳʹȌǤ ȋȌ ǣǦǤ ǣƬ ǡͺǡͳͶͶǤ ǡǤǤǡǡǤǡ ǡ ǤǡƬ ǡǤȋʹͲͳ͵ȌǤ Early intervention in psychiatry, 7(3) Ǥ ǡ ʹͺǦʹͺͶǤ ̵ Ǥǡǡ ǤǡƬǡǤȋʹͲͳͶȌǤǡClinical Psychology Review, 34 ǡǦǤ ȋȌǡͶͺʹǦͶͻͷǤ A ǡǤǡƬǡǤ ǤȋͳͻͻͶȌǤ Psychiatry research, 53 ȋȌ Ǥ ȋͳȌǡ͵ͳǦͶͲǤ ǡ Ǥ ǤǡƬ±ǡǤȋʹͲͳͺȌǤ Ǧ ǣ Schizophrenia and CommonǦ Ǥ ×ǡ Ǥǡ ǡ Ǥǡ Sense ǡ Ǥ ǤȋǤȌǡ ǡͳͻ͵ǦʹͲǤǡǣ Ǥ ǡǤǡǡǤǡǡǤǡǡǤǡ ǡ Ǥǡ ǡ ǤǤǡǤǤǤƬǡǤȋʹͲͳͺȌǤ ʹͶ Schizophrenia research , 206, Ǥ ͵ͻͶǦ͵ͻͻǤ
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ǡǤǤǡǡǤǤǡ ǡǤ Ǥǡ ǡǤǡ ǡǤǡƬ ǡǤǤȋʹͲͳ͵ȌǤ ǣǤSchizophrenia bulletin, 40 ȋͶȌǡͺͳ͵Ǧͺʹ͵Ǥ ǡǤǡ ǡǤǡǡ ǤǡǡǤ ǤǡǡǤǤǡ ǡǤǡǤǤǤƬ ǡ Ǥ ȋʹͲͳͻȌǤ Journal of consulting and clinical psychǦology ǣ87 Ǥ ǡ ȋʹȌǡͳͷͳǤ ǡ Ǥǡǡ ǤǡǡǤǤǡƬǡǤǤȋʹͲͲͷȌǤǡ Acta ǣ ǤPsychiatrica Scandinavica, 112 ȋͷȌǡ͵͵ͲǦ͵ͷͲǤ ǡǤǡǡǤ ǤǡǡǤǡǡǤǤǡ ǡǤǡǡǤǡǤǤǤǡƬǡǤ ȋʹͲͳȌǤǡ ǡ ǣSchizophrenia bulletin, 42 Ǥ ȋ͵ȌǡͳʹǦʹʹǤ ǡǤǤǡƬǡǤǤȋʹͲͲͻȌǤ ȋ ȌPsychiatry research, 166 ǣǤ ȋʹǦ͵ȌǡͳͶͳǦ ͳͶǤ ǡǤ ǤǡƬ ǡǤȋʹͲͳʹȌǤJournal of theǦ American Academy of ǦChild ǣ & Adolescent Psychiatry 51 Ǥ Technicalǡ ȋͳʹȌǡͳ͵ͲͶ adaptationsǦͳ͵ͳ͵Ǥ from MBT to Schizophrenic Psychosis. Working on the Self ǡǤȋʹͲͳͺȌǤBoundaries ǡ ǡǡǤ ǡǤǤǡǡ ǤǤǡƬǡ ǤǤ ǤȋʹͲͲͶȌǤǦǣ Ǥ ǡǤǤǡ ǡǤǤǡƬǡǤMindfulness and acceptance: Expanding the cognitive-behavioral tradition ǤȋǤȌǡ ǡͶͷ– ͷǤǡǣ Ǥ ǡ ǤǦǤǡǡǤǡǡǤǤǡSchizophreniaƬǦ ǡǤȋʹͲͳ͵ȌǤ bulletin, 39 ǣǤ ȋȌǡͳͳͺͲǦͳͳͺǤ ǡǤǡ ǡǤǡǡǤǡ ǡ ǤǡƬǡ ǤȋʹͲͲȌǤThe British Journal of Psychiatry, 191 ǣǦǤ ȋͳȌǡͷǦͳ͵Ǥ òǡǤǡǡ Ǥǡǡ ǤǡǡǤǡƬǡǤȋʹͲͳͶȌǤ Social psychiatry and psychiatricǦ ǣǤ epidemiology, 49 ȋ͵Ȍǡ͵ͷͻǦ͵Ǥ ǡǤǡǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͲȌǤActa ǣ ǤPsychiatrica Scandinavica, 116 ǡͳͲͷ–ͳͳʹǤ
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ǡǤǡǡǤǤǡ ǡǤǡ ǡǤǤǡǡǤǡǡ ǤǡƬǦ ǡ Ǥ BritishȋʹͲͳͳȌǤǡ Journal of ClinicalǦ Psychology,ǡǣ Ǥ 50 ȋʹȌǡͳͺǦͳͻͷǤ ǡǤǤǡǡǤǡǡǤǡƬǡǤǤȋʹͲͳȌǤǦ Psychiatric rehabilitation journal, 39(4) Ǥ ǡ͵ͷʹǤ Dialogues in clinical ±ǡ ǤȋʹͲͲȌǤ Ǥneuroscience 8 ǡ ȋͳȌǡͷͻǤ ǡǤǤǡǡǤǡ ǡǤǡǡǤǡǡǤǡǡǤǡǤǤǤƬ Ǧ ǡ ǤȋʹͲͳͷȌǤ Psychological Medicine 4 Ǥ ǡ ͷȋȌǡ ͳ͵͵Ǧͳ͵Ǥ ǡǤǡ ǡǤǡǦ ǡ ǤǡǡǤǡ ǡǤǡ ǡǤǡǡǤǡǡ Ǥǡǡ ǤǡƬǡǤȋʹͲͳͺȌǤ Psychiatry research, 1 ǡ ǡ Ǥ ȋʹͲȌǡͶͷͳǦͶͷǤ World Population Prospects: the 2019 revision ȋʹͲͳͻȌǡ Ǥ ǣȀȀǤǤȀǦȀ ʹ ʹͲʹͲǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳʹȌǤ ǣSchizophreniaǦ´ bulletin, 38 Ǧ ǡ Ǧ Ǧ Ǥ ȋͶȌǡ ͳǦͳǤ ǡǤǡǡ ǤǡǦǡǤǡǡ ǤǡƬ ǡǤȋʹͲͳȌǤǡPsychological
medicine, 46 ǣ Ǥ A ȋͳȌǡ͵͵͵ͻǦͶͺǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬ ǡ ǤǦǤȋʹͲͳȌǤBMC Ǧpsychiatry, ǣ 16 Ǥ ȋͳȌǡͳͻͳǤ ǡ ǤǤǡǡǤǤǡƬ ǡǤ ǤȋʹͲͲͲȌǤ ȋȌ Psychopharmacology, 150 Ǥ ǡ͵ͻͻ–ͶͲ͵Ǥ ǡǤǡǡǤǡǡǤǡƬǡǤȋʹͲͲͺȌǤSchizophrenia ǣ ǡ ǡ Ǥbulletin 34 ǡ ȋ͵Ȍǡͷʹ͵Ǧͷ͵Ǥ
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Valorization
Ǥ transference of knowledge is sometimes referred to as ‘valorization’, defined as “the process of ǡ ǡ ǡ new businesses” (Knowledge Transfer Office, Maastricht University). Ǥ ǤͷͳͲͲͲ ȋòǤǡʹͲͳͺȌͷͺ ǡ ȋȌǤ ȋǡ ƬǡʹͲͲͺȌǡ Ǥ ǡ ǡ Ǥ ǡ ȋǡƬǡʹͲͲȌǤǡͳͲͲ ȋ ǡ ƬǡʹͲͳͷȌǡ ȋǤǡʹͲͲͷǢ ǤʹͲͳͺǢǤǡʹͲͳͻȌ ȋƬǡʹͲͳͶȌǤ ǡ ‘mentalizing’, impairments in NAPD (see Lana et al., 2017 for an overview), evidence that social ȋ ǡ ƬǡʹͲͳͻȌ ȋǡ ǡǡ ǡƬ ǡʹͲͳͺȌ ǡ ȋ ǤǡʹͲͳͻȌǤ ǡ ȋȌ ǡ Ǥ– referred to as the ‘sleeper effect’ – ȋǡ ǡ ǡƬǡʹͲͲͻǢǡǤǡʹͲͳʹǢ ǤǡʹͲͳͷȌ ȋƬ ǡʹͲͲͳǢʹͲͲͺȌǤǡ
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ǡ Ǥ ǡ ǡ Ǥ ǡǦ Ǥ ǡ Ǥ ǦP’s effects and the best way to implement it. Future research should establish whether Ǧ Ǥ Ǥ ǡ Ǥ ǡ Ǥǡ Ǥ ǡ ǡ Ǥǡ Ǥ Ǥ Ǧ ǡ ȋǤǡʹͲͳʹȌ ȋǤǡʹͲͳͷǢǡ ǡǡƬǡ ʹͲͲͷȌǡ ǦȋǡʹͲͳͻȌǤ ǡ ǡ
ǡ Ǥ A ǡ ǡ ȋǤǡʹͲͳȌǤ References
ǡǤǡƬ ǡǤȋʹͲͲͳȌǤAmerican ǣͳͺJournal of psychiatry, 158 ǦǦǤ ȋͳȌǡ͵ǦͶʹǤ ǡǤǡƬ ǡǤȋʹͲͲͺȌǤͺǦǦAmerican Journal of ǣPsychiatry, 165 ǦǤ ȋͷȌǡ͵ͳǦ͵ͺǤ
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ǡǤǡǡǤǡ ǡǤǡǡ Ǥǡǡ ǤǡǡǤǤǡǤǤǤƬǡǤ ȋʹͲͳͻȌǤ Psychiatric rehabilitation ǣ journal. ǦǤ
ǡǤǡƬǡǤǤȋʹͲͳͶȌǤ Dialogues in clinical neuroscience 16 Ǥ ǡ ȋͶȌǡͷͲͷǤ ǡǤǡǡǤǡǡǤǤǡǡ ǤǡǡǤǤǡƬ ǡǤǤȋʹͲͲͷȌǤSchizophrenia ȋȌ ǤResearch, 74 ȋʹǦ͵ȌǡʹͲͳǦʹͲͻǤ ǡǤǤǡǡǤǤǡƬǡǤǤSchizophreniaȋʹͲͲȌǤ bulletin 32 ǣǤ ǡ ȋͳȌǡͶͶǦ͵Ǥ ǡǤǡǡǤ ǤǤǡǡǤǤǡ ǡǤǡǡǤǡǡ ǤǡǤǤǤƬǡ Ǥ ǤǤȋʹͲͳͻPsychologicalȌǤ ȋ Ȍ Medicine 49 Ǥ ǡ ȋʹȌǡ͵Ͳ͵Ǧ͵ͳ͵Ǥ ǡǤǤǡ ǡ Ǥǡ ǡǤƬǡ ǤȋʹͲͲͻȌ Harvard ReviewǦ of ǣPsychiatry 17 Ǥ ǡ ȋͳȌǣͳ–ʹ͵Ǥ Nature Reviews ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͷȌǤ ǤNeuroscience, 16 ȋͳͲȌǡʹͲǤ ǡǤ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͻȌǤ ǣWorld Psychiatry 18 Ǥ Knowledgeǡ ȋʹȌǡͳͶ TransferǦͳͳǤ Office. ǡ ǤȋʹͲͳȌǤ ʹͲͳͻǡ ͳʹǣȀȀǤ ǤȀǦȀǦ ȀǦǦ Ǥ ǡ Ǥǡ ǡǤǡ ǡǤǡǦǡ ǤȋʹͲͳȌǤ ǣ Schizophrenia treatment. Ǥ Ǥ ǡǤǤǡǡǤǡǡǤǤǡ ǡǤ ǤǡƬ ǡǤȋʹͲͳͺȌǤ BMC psychology 6Ǧ ǡ ǣǦǤ ǡ ȋͳȌǡ͵ʹǤ ǡ ǤǡǡǤǡ ǡǤ ǤǡǡǤǡǡ ǤǤǡǡ ǤǤǡǤǤǤƬǡǤ ȋʹͲͳͷȌǤ The Lancet Psychiatry 2 Ǧ ǣ Ǥ The globalǡ ȋȌǡͶͺburden ǦoͲǤf disease: 2004 update. ǡǤǡ ǡǤǤǡƬǡ ǤǤȋʹͲͲͺǤȌ ǣ Ǥ
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ǦòǡǤǡǡǤǡƬǡǤȋʹͲͳͺȌǤ Ǥ ǦǤ ǡͳ͵ȋͶȌǡͲͳͻͷͺǤ ǡǤǡ ǡǤǡǡ ǤǡǡǤ ǤǡǡǤǤǡ ǡǤǡǤǤǤƬ ǡ Ǥ ȋʹͲͳͻȌǤ Journal of consulting and clinical psychologyǦ ǣ87 Ǥ ǡ ȋʹȌǡͳͷͳǤ ǡǤǡǡ Ǥ ǤǡƬǡǤȋʹͲͳȌǤPsyXpert Ǧ Ǥ ǡͶʹǦͷͲǤ ǡǤȋʹͲͳͻǡ͵ͳȌǤ´ Ǥ ǡǤͳǤ ǡ ǤǤǡǡǤ ǤǡǡǤǡ ǡ ǤǡǡǤǡƬǡǤȋʹͲͳʹȌǤǦ ǣ Psychotherapy 49 Ǧ Ǥ ǡ ȋ͵ȌǡʹǤ ǡǤǤǡǡǤǤǡǡǤǤǡǡǤǡ ǡǤǡǡǤǡ Ƭ ǡǤȋʹͲͳͷȌǤ JAMA psychiatry 72 ǣ Ǥ ǡ ȋ͵ȌǡʹͷͻǦʹǤ ǡ Ǥǡǡ ǤǡǡǤǡǡǤǡǡǤǡ ǡǤǡǤǤǤƬǡǤǤ ȋʹͲͳʹȌǤ ǣSchizophreniaǦ bulletin 38 Ǧ ǡ Ǧ Ǧ Ǥ ǡ ȋͶȌǡ ͳǦͳǤ ǡ Ǥǡ ǡ ǤǡǡǤ ǤǡƬǡǤȋʹͲͲͷȌǤ ǣSchizophrenia research 77 Ǧ Ǥ ǡ ȋͳȌǡͳWorldǦͻǤ Population Prospects: the 2019 revision
ȋʹͲͳͻȌǡ Ǥ A ǣȀȀǤǤȀǦȀ ʹ ʹͲʹͲǤ
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List of publications and invited lectures
Peer-reviewed journal articles
ǡǤǤǡǡ Ǥ ǤǡǡǤǤǡ ǡ ǤǡƬǡǤȋʹͲͳͶȌǤ ǣ European Journal of Socialunconsciously Psycholo activatedgy, 44 behaviour that violates one’s standards. ǡʹͷͷǦʹǤ ǡ ǤǡǡǤǡǦǡǤǡ ǡǤǡǡǤǡǡǤǡƬ ǡ ǤǤȋʹͲͳȌǤBMCǦ psychiatry, ǣ 16 Ǥ ȋͳȌǡͳͻͳǤ ǡǤǤǡǡ ǤǤǡǡ Ǥǡ ǡǤǤǡƬǡ ǤȋʹͲͳͺȌǤEuropean Journal of Social Psychology, 48 Ǥ ȋͳȌǡͳͷǦʹͶǤ ǡ Ǥǡ ǡǤǡǦǡǤǡǡ Ǥǡ ǡǤǡƬǡ ǤǤ ȋʹͲͳͺȌǤ Psychiatry research, 259 Ǥ ǡͶ͵ǦͶͻǤ ǡ Ǥǡ ǡǤǡǦǡǤǡƬǡ ǤǤȋʹͲͳͺȌǤ ǣ Frontiers in psychiatry, 9 Ǥ Ǥ ǡǤǡǡ Ǥǡ ǡ ǤǡǦǡǤǡƬǡ ǤǤȋʹͲͳͻȌǤ Schizophrenia research. ǣ Ǥ ǡ Ǥ ǤǡǡǤ±ǡǤǡǡǤǤǡǡ ǤǦǤǤ ǡƬǦǡ Ǥ ǤǤȋʹͲʹͲȌǤ ǣJournal of Contemporary Psychotherapy, . Ǧ Ǥ ͳǦͳͲ ǡ Ǥ ǤǡǡǤǡ ǡǤǤǡǡǤ ǤǤǡǡǤ ǤǤǡƬǡ ǤǤ ȋʹͲʹͲȌǤǦ ǣPsychological Medicine. ǦǡǦ ǡ Ǥ Trade journal article
ǡǤǡǡ Ǥ ǤǡǡǤȋʹͲͳȌǤPsyXpert Ǧ Ǥ ǡͶʹǦͷͲǤ
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Invited lectures
ǡ Ǥ Ǥǡ ǡǤǡMentalizing impairmentǦǡǤǡǡ Ǥǡ ǡǡ as mediator between reported childhood abuseƬ andǡ ǤǤ ȋʹͲͳȌǤoutcome in nonaffective disorder. ǣ ǡǡǤAttachment processes in the development of psychosis: childhood trauma, ǡ Ǥ ǤȋʹͲͳͺȌǤmentalizing and loneliness Ǥǣ ǡ ǡǤChildhood abuse, loneliness and mentalization in non-affective psychotic ǡ Ǥ ǤȋʹͲͳͺȌǤdisorder ǡǣ ǡǡǤ Mentaliseren bevorderende therapie bij ǡ Ǥ ǤǡǡǤǡƬ ǡ ǤȋʹͲͳͻȌǤpsychotische stoornissen. ǡ ǡǤ
A
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Dankwoord
Lotte
Ǥ ǡǤ Ǥ ±±ǣǡǨ Ǥ Pap en mam Ǥ ǡ ǡǤ ǤòǡPap Ǥ ǡ ǡ ǤMam , van jou ‘erfde’ ik de liefde voor de psychodynamische benadǡǡ transparantie en begrip voorop staan. Jesse en Nina, wat een geluk heb ik met zo’n lieve broer Ǥ ǡDaan en Sanne ǤǡȋȌǨ ǡ Ǩ Ǥ Jos en Coby Ǥ ǡ Ǥ ǡ ǨAlle deelnemende patiënten Ǣ Ǥ Ǥ ȋǨȌ Ǥ ǡǡCoriene ten Kate Ǥ ǡǡǤ Ǥ Ã Ǥ ǡ ǡ ǤProf. J.P. Selten, beste Jean-Paul ǡ Ǥ Ǥ Ǥ± ǡ
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Ǥ Ǣ̶̶Ǥ Ǥ ǡ ǡǤ ‘zondigde’ hardnekkig door, ook al was dat toen niet modieus. Gelukkig heb je met je visie en ǡProf. Dr. Elisabeth Eurelings-Bontekoe, beste Liesbeth Ǥ ǡ ǡ Ǥ ǡ Ǥ ǡ Ǥ zware tijden kon je er oprecht zijn voor mij. Dat vind ik zó’n mooie eigenschap. Jouw klinische Ǥǡ ǡǤ ǡ Ǥ Ǥ ǤDr. Viechtbauer dear Wolfgang ǡ ǡ Ǥǡ ǡ ǤDear Martin Debbané, Anthony Bateman Peter Fonagy, Ǥ ǡǡǡ Ǥ ǡǤ
ǡ A ǤMBT- gedreven,team in Voorhout consciëntieuze collega’s heb mogen werken.Rutger Rampaart, Allereerst Irma natuurlijk Siecker, dank Rosa aan Klaver, het Yvonne Noij, Andrea Landman, Iliana Borisova, Mary Boes, Heidi Geutjes . VIP-team Leiden ǡLeon Jansen Willem Ǥ Jan van Utrecht ǡAnneke Duijn Ǥ Ǥ ǡǡWijkteam Zoetermeer Ǥ Ester Schellingerhout,Ǣ Ǩ
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Nandl Lokhorst, Maaike van Hooff en Karin Schoenmaker FACT-team
Altrecht Zeist PeterǤ van Beek, Yolanda Licher, Erik Smid, Sonja Knecht enǡ Sabine Werr Ǥ Els Ǥ Ǥ Ǥ Ǥ Fabian Ǥ ǡ Ǩ ǡ ǡ ǤYvonne ǫ ǡ ǡ Jori, ǡ Ǥ Ǥ ǡǨ Rik, Ǥ ǡǤ ǡCarmen ǡ JP Ǥ ǡ ǡǨ ǢǦȌǤ ǡǤ Hanneke van der Werf, Latifa si AmerValentein Hol Ǥ Floor van den Berge ǡǡ Patrick Imanse ǨǤ ǡ Ǩ ǡǤJorinde Gerrmann Lisa Steenkamp ´Ǥ ǡ ǡ Ǥ Marleen van Pelt Emma Deckers ǡ ǦǤ ǡ Ǩǡ ȋEsther van Zoen ȌǤ ǡ Ǥ Ǥ ǦǤ Ǥ
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GZ19B
ǤǡǦFleur van Ierschot ±Ǥ ǡ Ǧ ǤǡMieke de Jong, Yvonne Verburg, Michael Holwerda, Koert Velders, Daan Jonkerǣ Ǥ Wijkteam Gouda makenWest en datPolikliniek is goed gelukt! Gouda Daarnaast moet ik absoluut ook mijn collega’s van noemen. Dank dat jullie mij zo’n prettige tijd hebben gegeven! ǤSchool of Mental Health and Neuroscience Debora op ‘t Eijnde Truda Driesen Ǥ Ǥ ͶǨ lifeline Ǥ Ǥ directie van GGZ Rivierduinen ´ Ǥlast but not least Eddie, ǡǡǡ Ǥ ±±ǫ ǡ Ǥ ǤǣǨ ǡǤǦ Sjoerd Ǥ Ǥ ǡǡ ǡ te beroerd om iets voor een ander te doen. Je bent zo’n fijne maat en toffe vent. Heel gaaf (en
Ȍ A Ǥ Ǥ Roel Ǥ ǡ JeroenǤ ǡ Ǥ ǡ Ǥ Ǩ ǤǫRalf, ǫ ǡ Ǥ laat je niet leiden door algemene verwachtingen of ‘hoe het hoort’, Rickm ǤǤ ǡ Ǥ ǡ
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Reinier
ǤǤ ǡ Ǥ Ǥ ǡǡ ǡǤJaapiooooo, Ǥ × ǫ ȋ iskey om 11 uur ‘s ochtends)! Wat begon als een jazzband (hoeStefan heetten we ook alweer?!) is Ǥ ǡ Ǩ Ǥ ǡǤ ´creepy Martin ǡ Ǥ ǡ Ǥ ȋƬǨȌWijnand ȋȌǡǨ ǡ Ǥ Mieke, Ǥ Ǥ ǡ Ǥ Ǥ Steven Ǥ ǡ Ǥ Ǧ Ǩǡ ǤǤ Ǥ ǤGijs en Femke! ǡ ȋ ǫȌǤ ± Ǥ ǡǤ
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Curriculum Vitae
ͺǡͳͻͺǡǤ Stedelijk Gymnasium ͳͻͻͺʹͲͲͶǡ ǡ Philosophy. He obtained his bachelor’s degree in 2009. Having discovered both a passion for Social and He–alth Psychology Clinical Psychology – master’s programsSelf at RegulationUtrecht University. Lab After university he started working as a juniorAltrecht Mental Health Institute Ǥ RivierduinenʹͲͳ͵ Mental Health Institute Maastricht UniversityǦ ǡ Ǥ ʹͲͳͻǡǦǦmaster’s program to become Ǧ ǡ Ǥ A
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