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OMB No 0925-0001 and 0925-0002 (Rev 10/15 Approved Through 10/31/2018) __________________________________________________________________________________ BIOGRAPHICAL SKETCH NAME POSITION TITLE Associate Dean for Research and Graduate Marcia F. McInerney___________________ Studies (protected time for research) Distinguished University Professor eRA commons user name Medicinal and Biological Chemistry mmciner College of Pharmacy and Pharmaceutical Sciences University of Toledo EDUCATION/TRAINING INSTITUTION AND LOCATION YEAR(s) FIELD OF DEGREE STUDY University of Michigan Ph.D. 1989 Microbiology & Immunology Yale University School of Med. Postdoc 1989-1991 Immunobiology- Dr. Charles A Janeway Jr, Mentor Joslin Diabetes Center/Harvard School of Visiting Prof 1998-1999 Diabetes/ Medicine of Medicine/ Endocrinology Iacocca Fellow University of Michigan Visiting Prof 2008 Metabolism, of Internal Endocrinology, Medicine and Diabetes A. Personal Statement I have been involved for over 25 years in research on the autoimmune aspects of type 1 diabetes (T1D) and inflammation in type 2 diabetes (T2D). While in the Janeway Laboratory for my postdoctoral we were the first lab to show that islets in nonobese diabetic (NOD) mice did not express MHC class II molecules, but that expression of MHC class I increased significantly during the development of diabetes. Therefore, we established that beta cells were not presenting antigen to CD4 T cells (last publication listed). I have worked actively on autoimmunity in type 1 diabetes as evidenced by publications on autoantigens (insulin, glutamic acid decarboxylase), autoantibodies (anti-insulin receptor), T cells (CD8 and CD4), T cell clones and hybridomas (anti-insulin, antiGAD), humanized transgenic mice expressing the diabetes susceptibility DQ8 molecule that turned out to be an autoimmune model of human myocarditis, and the role of the insulin receptor in diabetes development which was supported by NIH. -
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Boston Children’s Hospital and the Bold Ideas that Change the World 3 For the children, families, healers and scientists of Boston Children’s Hospital. Together, they break through the impossible to create healthier futures for all. Break Through: Boston Children’s Hospital and the Bold Ideas that Change the World Copyright © 2019 by Boston Children’s Hospital All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without written permission from the publisher. Editor and writer: Laurie Beckelman Designer: Mary Ann Guillette Contributing writer: Nicole Davis Published 2019 Second Edition 2019 Printed in Canada WITH GRATITUDE Generous donations from the following physician foundations, hospital departments and philanthropic funds fully supported publication of Break Through: Boston Children’s Hospital and the Bold Ideas that Change the World. Boston Children’s Heart Foundation Boston Children’s Hospital Department of Dentistry Boston Children’s Hospital Trust Boston Pediatric Neurosurgical Foundation Boston Plastic & Oral Surgery Foundation Children’s Hospital Department of Psychiatry Children’s Hospital Neurology Foundation Children’s Hospital Ophthalmology Foundation Children’s Hospital Pathology Foundation Children’s Hospital Pediatrics Associates Children’s Hospital Radiology Foundation Children’s Orthopaedic Surgery Foundation Children’s Sports Medicine Foundation Children’s Urological Foundation CHMC Anesthesia Foundation CHMC Cardiovascular Surgical Foundation CHMC Otolaryngologic Foundation -
In This Issue…
AAI Councillors Visit Capitol Hill, Extol Value of NIH Research See page 3 N FASEB Celebrates Its Centennial 12 AAI Looks Back—The 1918–1919 In This Issue… on Capitol Hill Influenza Pandemic 2 2012 AAI Election Results N NCATS Forms Industry Partnership 14 2012 AAI Annual Meeting Highlights N Does Your Degree Impact Your ™ 3 Focus on Public Affairs: 22 IMMUNOLOGY 2012 Sponsors NIH Funding Prospects? N AAI Holds Special Session on 24 Grant & Award Deadlines N New Dual Use Research Policy NIH Peer Review 28 Meetings Calendar N NIH Director Collins on TV N AAI Research Advocacy Program Engages 5 Key Partners 7 2012 AAI Advanced Immunology Cover Image: Course Program N FY 2013 NIH Funding Bill Clears Galacidalacidesoxiribunucleicacid Senate Committee 8 Members in the News See page 3 for details. 2012 AAI Election Results AAI congratulates the following members on their election to offices and committees for terms commencing July 1, 2012, and extends a sincere thanks to all candidates for their willingness to run and serve if elected. President (2012–2013) Nominating Committee The American Association Gail A. Bishop, Ph.D. (2012–2013) of Immunologists Carver College of Medicine Pamela S. Ohashi, Ph.D., F.R.S.C., Chair 9650 Rockville Pike Distinguished Professor of Microbiology Senior Scientist and Director Bethesda, MD 20814-3994 and Internal Medicine and Holden Immune Therapy Program Tel: 301-634-7178 Chair of Cancer Biology Ontario Cancer Institute Fax: 301-634-7887 University of Iowa Michael Croft, Ph.D. E-mail: [email protected] www.aai.org Vice-President (2012–2013) Professor and Head, Division of Marc K. -
Bridging Innate and Adaptive Immunity
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Leading Edge BenchMark Bridging Innate and Adaptive Immunity William E. Paul1,* 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA *Correspondence: [email protected] DOI 10.1016/j.cell.2011.11.036 The Nobel Prize in Physiology or Medicine for 2011 to Jules Hoffmann, Bruce Beutler, and the late Ralph Steinman recognizes accomplishments in understanding and unifying the two strands of immunology, the evolutionarily ancient innate immune response and modern adaptive immunity. Among the 15 Nobel prizes given for siveness. The celebration of immunolo- the eponymous complete Freund’s adju- discoveries in immunology, including the gists everywhere in response to this vant, consisting of killed Mycobacteria very first, the 2011 prize can be best well-deserved prize is tempered with tuberculosis organisms in a water-in-oil compared to the 1908 prize, shared by sadness, with Ralph Steinman having emulsion. two giants of modern science, Paul died on the Friday preceding the Monday Although this need to use adjuvants to Ehrlich and Ilya Metchnikoff. In awarding announcement of the award. obtain a robust immune response to that prize, the Nobel committee attemp- protein antigens was widely appreciated, ted to grapple with the divide that had Exploring Immunology’s ‘‘Dirty it was papered over as immunologists’ already arisen in the then infant -
Harvard University History of Named Chairs
HARVARDUNIVERSITY HISTORYOF NAMEDCHAIRS Sketches of Donors and Donations PROFESSORSHIPS OF THE FACULTIES OF MEDICINE AND PUBLIC HEALTH 1721 – 1992 CAMBRIDGE, MASSACHUSETTS 2005 Copyright © 2005 President and Fellows of Harvard College For additional copies, contact Harvard University Alumni Affairs and Development, at 1-800-VERITAS. Contents Foreword . vii Professorships of the Faculty of Medicine Harriet Ryan Albee Professorship . 3 American Cancer Society Research Professorships . 4 John Emory Andrus Professorship of Genetics . 6 Julia Dyckman Andrus Professorship of Pediatric Surgery . 7 William Applebaum Professorship . 10 Edith M. Ashley Professorship . 13 K. Frank Austen Professorship in Medicine . 15 W. H. Baker Professorship of Gynecology . 17 Theodore Bevier Bayles Professorship of Medicine . 20 Baruj Benacerraf Professorship in Pathology . 22 Helen Andrus Benedict Professorship of Surgery . 26 William Berenberg Professorship in Pediatrics . 27 George Packer Berry Professorship . 30 Herrman Ludwig Blumgart Professorship of Medicine . 33 John B. and Buckminster Brown Professorship of Orthopedic Surgery . 36 Bullard Professorship of Neuroanatomy . 39 Bullard Professorship of Neuropathology . 41 Bullard Professorship of Psychiatry . 44 Paul C. Cabot Professorship of Medicine . 46 William Bosworth Castle Professorship of Medicine . 50 Benjamin Castleman Professorship . 53 William Ellery Channing Professorship of Medicine . 56 William F. Chatlos Professorship of Ophthalmology . 58 Cheever Professorship of Surgery . 60 Edward D. Churchill Professorship of Surgery . 63 Stanley Cobb Professorship of Psychiatry and Psychobiology . 65 David G. Cogan Professorship of Ophthalmology . 69 Elliott Carr Cutler Professorship of Surgery . 73 Herman Dana Professorship of Medicine . 77 Julieanne Dorn Professorship of Neurology . 80 A. Werk Cook Professorship . 83 Philip H. Cook Professorship of Radiology . 85 Bronson Crothers Professorship of Neurology . -
Printed in U.S.A
0031-3998/04/5602-0169 PEDIATRIC RESEARCH Vol. 56, No. 2, 2004 Copyright © 2004 International Pediatric Research Foundation, Inc. Printed in U.S.A. Acceptance of the 2003 John Howland Award: A Journey in Clinical Research DAVID G. NATHAN Thank you, Fred, for that fulsome description of my efforts discovery of sulfanilamide and penicillin. By the end of World to meet the standards of Charles A Janeway, a Howland War II, the biomedical revolution had begun and my grandfa- awardee, whom we both served with such admiration and ther’s view of medicine was on its way to obsolescence. respect. Of course, no one knows more than you about the Academic medicine was to become a bastion of biomedical leadership of Children’s Hospital in Boston. You have been the science. This change is important to us today at this celebration right arm of no less than five chiefs of our Department. You because John Howland was part of the Osler tradition. William have been best described by Gary Fleisher, our present chief, of Osler had no interest in laboratory-based or high-tech medical what you, Bill Berenberg, Fred Rosen, and I have always research. He believed that physicians should make an academic called Dr. Janeway’s department. Gary’s first act as chair was contribution by careful annotation of even more careful patient to reappoint you as vice-chair of the department. Shortly observations. Osler’s view notwithstanding, Vannevar Bush’s thereafter, Gary called me to tell me that he had made a 1945 white paper entitled “Science the Endless Frontier” (2) discovery. -
Charles A. Janeway, Jr. February 5, 1943− April 12, 2003 Richard W
Charles A. Janeway, Jr. February 5, 1943− April 12, 2003 Richard W. Dutton and M. Michele Hogan This information is current as J Immunol 2003; 171:6314-6315; ; of September 25, 2021. doi: 10.4049/jimmunol.171.12.6314 http://www.jimmunol.org/content/171/12/6314 Downloaded from Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists http://www.jimmunol.org/ • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription by guest on September 25, 2021 Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2003 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. THE JOURNAL OF IMMUNOLOGY IN MEMORIAM Charles A. Janeway, Jr. February 5, 1943–April 12, 2003 harles (Charlie) A. Janeway, Jr., died on April 12, 2003 at age 60 following a long illness. At the time of his C death, Janeway was Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale Uni- versity School of Medicine. Janeway was also an Investigator of the Howard Hughes Medical Institute. Scientist, teacher, and author, Janeway was an astounding in- tellect and a Renaissance man of immunology. -
Yale Medicine Magazine
yale medicine spring 2002 on t he cover Ro b e rt U d e l s m a n’s arrival at Yale last June as chair has foc u s e d major attention on the Depart- ment of Surgery. Recruited from Johns Hopkins, where he helped develop new techniques for thyroid and parathyroid surgery and made laparoscopic adrena- lectomy standard,Udelsman has sethis sights on making the department one of the world’s leaders. Page 16 Cover photograph by Sean Kernan s p r ing ya l e me d i c i n e 2 0 0CO 2 NTE NTS This season on the We b 2 L E T TE RS info.med.yale.edu/ymm 4 CHRO NI CL E Ex p l o re the fo l l owing topics in 8 RO UND S g re ater depth by visiting our 10 F IND IN G S website and selecting ext r as : 12 BOO KS –Surf the Janeway and 13 ON CAM P U S Medzhitov lab websites and 14 learn more aboutinnate CA PS UL E immunity. Pay a virtual visit to the Howard Hughes Medical Institute. 16 RE IN V E NTI NG SURG E RY – Visitthe ayam and learn Ro b e rt Udelsman left one of the busiest medical ce nters on the about Reunion 2002 (and view p l a n e t to lead Ya l e ’s Depart m e nt of Surge ry out of its doldrums and photos from 2001 reunions). i nto national pro m i n e n ce.