The NIH Record U.S. Department November 13 National of Health, 1979 lnstltut" Education, and Vol. XXXI of Welfare No.23 Health

Gilbert To Give Dr. Roth Wins First Hazen Award NIH Lecture For Outstanding Clinical Research

On Genes Dr. Jesse Roth, chief of the Diabetes Branch Dr. Walter Gilbert, professor of molecular of the National Institute of Arthritis, Metabo­ biology at Harvard University, will deliver the lism, and Digestive Diseases, has been named NIH lecture on Wednesday, Nov. 28, at 8:15 the winner of the first annual Lita Annenberg p.m. in the Masur Auditorium. Hazen Award for outstanding achievement in Dr. Gilbert, who will speak on The Struc­ clinical research. The $100,000 award was ture and Evolution of Genes, has been a leader presented to him on Nov. 1 at a dinner held in developing our understanding of the in his honor at the St. Regis Hotel in New molecular basis of cellular regulation. York City. Early in his career, Dr. Gilbert's attention The award, administered by the Mount was drawn to a problem which would be the Sinai School of Medicine, was established by basis of his research for many years: the noted philanthropist Mrs. Lita Annenberg molecular basis of the control of gene expres­ Hazen to encourage young physicians to sion in bacteria. Working with a cluster of pursue careers in clinical research. Mrs. genes associated with lactose metabolism, Dr. Hazen, in consultation with a committee of Gilbert transformed ideas about the nature of some of the country's leading scientists, gene expression, drawn from genetic analysis, designed the award program to promote into molecular mechanisms. clinical research for young researchers in In a series of innovative studies, he showed training. that all genetic phenomena could be ex­ Or. Roth, who joined NIAMDD in 1963, wu Half of the tax-free $100,000 prize goes to plained in terms of chemical interactions chosen for the Hazen award from ;among the winner, and the other half will be used to which could be precisely measured. This was nominations which included the world's fore­ support young physician researchers chosen the first elucidation of a molecular mechanism most medical researchers. by the winner to work with him. (See NIH LECTURE, Page 10) In his keynote speech at the award presen­ tation, NIH Director Dr. Donald S. Fredrickson dwelt on the significance of clinical research, and of Dr. Roth's contributions to such research. He paid particular tribute to Dr. Roth's understanding and sensitivity. "He merits this prize and our highest praise and congratula­ tions," he said. Dr. Fredrickson noted that this prize brings double joy to NIH. "The Hazen award is most unusual in providing an equal sum to the institution so that research fellows may be supported in the laboratory of the winner." In this way, he said, it provided for the "continu­ ity of recognized work" and honored "scientists in a fully productive phase of their careers." "For the past 25 years," he commented, "the Clinical Center's output of skilled scien­ tist clinicians has been unrivaled. Conse­ quently, we felt it was highly probable that the Hazen award would go to at least an alumnus. But for the first to be made to an incumbent scientist is, to us, a most gratifying confirmation of the Center's current contribu­ tion to clinical research." Dr. Roth was chosen for his achievements Dr. Gilbert looks at an ex;ample of the new method he developed for sequencing DNA. (See DR. ROTH, Page 7) The NIH Record Published biweekly al Bethesda, Md., by the Editorial Operations Br•nch, Division of Public lnlorm•tlon, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welf•re, and circulated by request to writers and to researchers In biomedical and related fields. The content Is rcprlntable without permission. Pictures may be available on request. The NIH Record reserves the right to make corrections, changes, or deletions in submitted copy in conformity with the policies of the paper and HEW.

NIH Racord 0ftlce Bldg. 31, Room 28--03, Phone 4%-2125

Editor fr•nces W. Davis Stall Wrllere William B. Relnckens Susan Johnson

Stall Correspondents ADA, Judy Fouche; CC, Susan Gerhold; DCRT, Mary Hodges; DRG, Sue Me.-.dows; DRR, Barbara Menick; DRS, Anhur F. Recently NIH Director" Dr. Donald S. Fredrickson addressed the newly promoted officers of the NIH Moore; FIC, Toby P. Levin; NCI, Dr. Robert M. Hadsell; police department. He praised the department and gave credit to the officers for their past performance. NEI, Ma,sha Corbett; NHLBI, BIii Sanders; NIA, Ann Dief­ fenbach; NIAID, Jeanne Winnick; NIAMDD, Linda Cross; The officers are shown at the promotion ceremony with their new badges and shoulder patches that NICHD, Pamela Driscoll; NIDR, Sally Wilberding; NIEHS, mark their transition from NIH Special Police to regular police. Standing (I to r): Officer Patrick Hugh J. Lee; NIGMS, Wanda Warddell; NIMH, Betty Wilson, Dr. Fredrickson, and Officers Edward Toms, James Frye, Francis Coleman, Harry Levine, and Zubovic; NINCDS, Doris Parker; NLM, Roger L. Gilkeson. Gerald Watson. (Seated I to r): Officers Ronald Hutchinson, James Koerber, John Spivey, Asa Langford, and Kenneth McOermon. Missing from the photo is Officer Oze lemons. Stride, Nursing Career Development Applicants Conflict Study Group To Brief Employees on Data Results Need Up-to-Date Transcripts The Employee Conflict and Cooperation Study Group will hold four meetings to brief Up to 20 new training positions for the NIH • Being in a nonprofessional position (one employees on the study results. Stride Program are expected to be announced grade promotions); These briefings are open to all NIH in January 1980. The program combines on­ • Working full-time or willing to accept a employees. There will be an opportunity to the-job training with academic study to full-time position; ask questions and offer interpretation of C1e prepare participants for professional positions • Having a high school diploma or GED data results. at NIH. certification, but not having a bachelor's The scheduled times are: degree; and Employees who anticipate applying for one Westwood Bldg., Conf. Rm. D, Thursday, or more of these positions should obtain Announcement on Bulletin Boards Nov. 15, at 2 p.m. up-to-date transcripts of completed college­ • Being in a GS 4 through GS 9 or wage Bldg. 31, Conf. Rm. 10, Monday, Nov. 26, level course work. Unofficial (student) copies grade equivalent position. (Those persons at at 9 a.m. must be used in this application process. the GS 9, 81 or in some cases 7, who are Bldg. 31, Cont. Rm. 10, Monday, Nov. 26, Those who do not have college credits selected will be required to request a down­ at 1 p.m. should obtain a copy of their high school grade to the highest grade announced for a Bldg. 1, Wilson Hall, Tuesday, Nov. 27, transcript or GED certificate. If employees are training position, but their pay rate will be at 1 p.m. unable to obtain a transcript, they should saved for a period not to exceed 2 years.) For more information, call Patricia prepare an OPM Form 226, List of College Please hold transcripts until the program is Scandrett, 496-1811 . Courses and Certificate of Scholastic officially announced in the Merit Promotion Achievement. Plan Vacancy Listing, posted on NIH bulletin Dec. 7 Deadline for Changes Forms Available in Personnel boards. In Health Benefits Plans Also, plans are being finalized to announce The Federal Employee's Health Benefits These forms are available in the Personnel 10 positions in the new 4-year Nursing Career Program offers eligible employees an "Open Staffing Branch, Bldg. 31, Rm. B3C-15. Em­ Development Program (formerly Stride Nurs­ Season"-now through Dec. ?-during which ployees without a transcript or Form 226 will ing Program) in early 1980. Unofficial they may enroll in 1 of 17 different plans, be ineligible to compete for a position. transcripts will also be needed to apply for change options or types of enrollment, or any Other requirements include: this program. Eligibility requirements and combination of these. • Being employed in a career or career­ information on how to apply will be conditional position at NIH for at least 1 year announced at a later date. A booklet, titled Open Season Instructions, immediately prior to the closing date of the Please call the Career Development Branch, BRI 41-117, will soon be distributed in a announcement; DPM, 496-6211, for additional information. packet to all employees. Brochures on the major plans and premium rates for all plans will be included. Registration assistants, listed on official Export of Nuclear Power Blood Bank Needs Donors bulletin boards, are now available to answer questions on the program and help employees Topic of Talk Supplies of life-sustaining blood are short, complete forms. The Export of Nuclear Power to the Third and the Clinical Center Blood Bank is asking World will be the topic of a speech to be for donors. Various Federal health plan representatives will answer individual questions concerning given at the Masur Auditorium, on Thursday, Please set aside the half hour it takes to coverage under their plans at a session to be Nov. 15, at noon by Jacob Scheer, Staff donate blood at the Blood Bank in Bldg. 10, held on Wednesday, Nov. 28, in B!dg. 1, Attorney for the Natural Resources Defense Rm 1E-33, from 8:30 a.m. to 5 p.m., Monday Wilson Hall, from 1 :30 to 4:30 p.m. Council, Washington, D.C. through Friday. Call the Blood Bank, 496-1048 Alt employees are invited, but permission Mr. Scherr's presentation is sponsored by or 496-1049. the NIH Solar Transition Committee. to attend should be cleared with supervisors.

Page2 The NIH Record November 13, 1979 Parking Permit Sales Going Smoothly; NIH'ers Take Their Case Against Enforcement of Regulations To Begin Soon Paid Parking to the White House

NIH Parking Office officials say they are An estimated 500 Federal employees, most " more than pleased" with the way sales of of them NIH'ers from the Westwood Bldg. parking permits have been going. The biggest and the main campus, gathered at the White problem they've encountered has been House Oct. 26 to protest paid parking. occasional long lines waiting to purchase the Two petitions, one signed by Westwood permits. employees and one signed by other NIH The lines are caused largely by customers employees, were presented to an aide to asking questions and by people not having Anne Wexler, assistant to President Carter. their receipts and checks filled out before­ hand, say officials. To alleviate this problem, The Westwood petition; which contained they recommend that employees take their 1,000 signatures, asked the President to questions to their B/I/D parking coordinators exempt Westwood employees from paid and that they have their receipts and checks parking on the basis that there is no public ready when they get to the counter. tlf'ansportation to the building. Enforcement of parking regulations is The other petition, which contained more scheduled to begin Nov. 19, Owners of cars than 3,000 signatures, asked him to rescind parked on campus without permits will be the Executive Order requiring Federal em­ ticketed, say officials. ployees to pay for parking until the effects of Also on Nov. 19, the Parking Office will a parking fee on employees can be studied. begin selling permits for the month of The Westwood employees have also asked December. Starting with the December sale, NIH Director Dr. Donald S. Fredrickson to employees will be asked to purchase permits request a special exemption for them. On according to an alphabetical schedule. This Nov. 2, representatives met with NIH Deputy schedule and the permanent locations for Director Dr. Thomas Malone to discuss the buying permits will be listed in a desk-to-desk lack of public transportation to the Westwood memorandum. Bldg. and the fact that there are no paid B/I/D parking coordinators will begin dis­ A T-shirt worn by Cheryl Arnatucci, chief of the public parking lots nearby on which to base a Parking Office, speaks for itself. tributing permits to employees who are fee. exempt from paid parking during the week of A total of 9,000 parking permits can be sold Currently, Westwood employees are Nov. 12. Persons who are not sure whether on the NIH campus, say Parking Office required to pay $10 per month for parking, they are exempt should check with their officials. As of Nov. 2, almost 3,000 had been and employees on the main NIH campus coordinators. sold. must pay $12. Office Temperatures Will Be Lower This Winter

Employees may want to bring a warm sweater to work this winter because, as of Nov. 1, office temperatures at NIH have been set at 65° F. Turning down the thermostat this winter is the result of national energy legislation enacted in July. Although the law is more stringent than pre­ viously, it contains exceptions for hos­ pital patient areas and some research spaces. The Emergency Building Temperature Re­ strictions Regulations place temporary restric­ tions on temperatures for heating, cooling, and hot water for industrial, commercial, and nonresidential buildings until next April. Employees in Bldg. 31 purchase their parking permits. To speed up the process, Parking Office These regulations require that thermostats be officials recommend that people fill out their receipts and checks ahead of time. set no higher than 65 ° F for heating, no lower than 78° F for cooling, and no higher than Course in Basic MARK IV Offered on Nov. 27 105°F for hot water to wash your hands. On Tuesday, Nov. 27, the Software Support NIH Computer Utility. The Data Management Some Fluctuations Possible Section of the Division of Computer Research Branch provides support and programmer and Technology's Data Management Branch assistance for MARK IV. "The employees may experience some will teach a course in Basic MARK IV. This Interested programmers can still register fluctuations in heat," says John Bartgis, Main­ system is for programmers and systems for the Basic MARK IV course. For details, tenance Engineering Branch, Division of analysts involved in file management, infor­ consult the Computer Training Courses and Engineering Services, who has been busy mation retrieval, and reporting functions. Seminars Catalog or the DCRT Technical checking each NIH building to determine its The MARK IV Data Management System is Information Office, Bldg. 12A, Rm. 1017, (See TEMPERATURES, Page B) a computer software system available on the 496-5431 .

November 13, 1979 The NIH Record Pages Dr. Druker To Give Lecture Consensus Conferees To Examine Pros, Cons At TM Club Meeting on Laws Of Consciousness, Nature Of Removing Wisdom Teeth Dr. Steven M. Druker will speak on Laws of Consciousness and Laws of Nature: A Scien­ The advantages and disadvantages of second day of the conference to explore five tific Basis for Developing the Full Potential of removing wisdom teeth (third molars) will be separate topics: the effects of third molar the Individual and Society, on Friday, Nov. 16, examined at a consensus development confer­ removal on growth and development, the at noon, in the Masur Auditoril•-:1. ence sponsored by the National Institute of timing and technical considerations for Dr. Druker is Dental Research Nov. 28-30. surgery, implications for gum disease and professor of law The removal of wisdom teeth in young prosthetic devices, complications associated and government at adults has become an extremely common with extraction, and the advantages and the Maharishi Inter­ procedure and represents a significant portion disadvantages of extraction. national University, of the $10 billion Americans spend every year Oh the third day, the experts will try to Fairfield, Iowa, and on dental care. arrive at consensus on when and under what director of the The conference will begin Wednesday, Nov. circumstances extraction is advised, and to Institute for Law, 28, at 9 a.m., in the Masur Auditorium. At this identify areas where further research is Consciousness, and general session, practicing dentists, research­ needed. the Science of e rs, academicians, and members of the public Co-chairmen of the conference are Dr. Creative Intelligence will hear reports on the indications and Walter C. Guralnik, professor and chairman of in Washington, D.C. contraindications of third molar removal. the department of oral surgery, Harvard In his lecture he Dr. Druker One of the topics to be discussed will be School of Dental Medicine, and Dr. Daniel M. will examine major the influence of third molars on surrounding Laskin, professor and head of the department discoveries about the principles and dynamics structures such as tooth alignment, gum of o ral maxillofacial surgery, College of of consciousness and their intimate relation to tissue, and the supporting bone. Participants Dentistry, University of Illinois. NIDR coordi­ all other natural phenomena, as brought to will discuss the relationship of wisdom teeth nator is Dr. Richard L. Christiansen, chief, light through a comprehensive new science of to general health, with an emphasis on both Craniofacial Anomalies Program. consciousness-the science of creative localized problems and systemic diseases. The NI H sponsors periodic consensus develop­ intelligence developed by Maharishi Mahesh possible consequences of surgical removal ment conferences to bring together biomedi­ Yogi. such as postoperative infection and nerve cal research scientists, practicing clinicians, Professor Druker, whose talk is being damage will be examined. Also to be consid­ allied health care providers, consumers, and presented by the R&W-sponsored TM Club, ered will be the role of wisdom teeth others to assess the safety and effectiveness of has lectured extensively throughout North retention for future prosthetic rehabilitation. selected medical and dental technologies and and South America. Individual workshops will convene the procedures.

NLM Associates Begin Year of Training Ors. Childs and Yen Five new National Library of Medicine Join NICHD Council Associates were welcomed at a reception at Dr. Barton Childs, a pediatrician and spe­ the Library on Oct. 17. Alf are recent library cialist in human genetics, and Dr. Samuel Yen, school graduates who are beginning a year of an obstetrician specializing in reproductive intensive training at NLM. endocrinology, have been appointed to the The NLM Associate Program offers post­ National Advisory Child Health and Human graduates a unique training opportunity in Development Council. modern medical librarianship, automated Dr. Childs is professor of pediatrics and handling of biomedical information, and biology at Johns Hopkins University School advanced large scale information storage and of Medicine. retrieval techniques. The author of numerous articles concerning Five Associates Named genetics and child development, Dr. Childs has received many honors for his scientific Samuel Dove has an M.L.S. degree from achievements, including the E. Mead Johnson Pratt lnstitute's Graduate School of Library Award in 1958 and the William Allan Award and Information Science. His work experience from the American Society of Human Genetics includes service at the New York Public in 1973. library, Montrose VA Hospital, and Ramapo Dr. Yen is professor and chairman of the College of New Jersey. department of reproductive medicine, Uni­ Under the name Mwalimu Amani, he versity of California, San Diego. published a National Library Plan for Tanza­ nia. He also teaches SERLINE at NLM. Received Many Honors Gale Dutcher's M.L.S. degree is from He has written more than 200 articles C. W. Post College, Long Island University. concerning neuroendocrine regulation of For the past 4 years, she supervised an reproductive cycles, biological rhythms in immunology research laboratory in the NlM Associates (clockwise from center) are: Gale reproduction, and pregnancy-induced altera­ pathology department, Health Sciences Center Dutcher, Eileen Koff, James Marcetich, Sam tions in metabolism. at Stony Brook. She also has an M.S. degree in Dove, and Beth Weil. Among Dr. Yen's many honors for scientific zoology, which involved the study of the University of Wisconsin at Madison, has achievement are: the Upjohn Award from the effects of pesticides on spider behavior. worked as the information specialist of the American Fertility Society in 1975; the Ortho Eileen Koff's M.L.S. degree is from the Lithium Information Center at the University Award from the Society of Obstetricians and University of Illinois. Ms. Koff worked as a of Wisconsin's department of psychiatry. Gynecologists of Canada in 1979; and, most graduate assistant at the University of Illinois Beth Weil's M.L.S. is from the University of recently, the Green-Armytage Award from the library. Prior to this, she worked in the infor­ California at Berkeley. While there she Royal College of Obstetricians and Gynecolo­ mation center of a management consulting worked at the main library in the General gists, London, England, for basic and clinical firm. Reference Service section. She has also worked research in the neuroendocrine regulation of James Marcetich, with an M.L.S. from the at the Shields Library at Stanford. reproductive cycles and infertility.

Page4 The NIH Record November 13, 1979 Dr. Barondes Visits NIH as Fogarty Scholar Because the nervous system is very compli­ action of cell surface carbohydrates and cated, scientists study simpler eukaryotic proteins, called lectins, that bind specifically systems to learn the general mechanisms of to these carbohydrates. cellular associations, explains Dr. Barondes. The lectins have more than one carbohy­ The biological system used in many of drate binding site, he explains, and can these studies is cellular slime molds. These therefore bridge cells together by binding organisms are particularly interesting because, their surface sugars. Whether or not these in the absence of food, they congregate to molecules are specific enough to control form fruiting bodies containing two types of selective cell type or spe_cies associations is cells: those that form the stalk of the fruiting not yet known, he says. body and those that form the spores. Dr. Barondes uses chicken embryos as a When the food supply is again plentiful, model system for studying cellular associations the spores are transformed into one-celled in higher organisms. A major advantage of amoebae that do not associate with one chick embryos is the vast background knowl­ another until the food supply is once more edge about their development. He has found depleted; this is known as the vegetative several lectins in these embryos, but says their state. function is not yet known. Three biological properties of cellular slime Through studies on cellular associations, molds make them a good system for studying says Dr. Barondes, researchers hope to dis­ Dr. Barondes, whose research area is neuro­ cellular associations, according to Dr. cover how cells form patterns and segregate biology, studies cellular slime molds and chicken Barondes: into organs and tissues. They also hope to embryos to learn the general mechanisms of • They exist in forms where they associate gain an understanding of congenital abnor­ cellular associations. (in the fruiting body) and where they do not malities and of disorders such as metastatic associate (in the vegetative state). cancer which may be caused by impairment Visiting NIH through December as a • They are cell type specific. Some cells of cellular associations. Fogarty Scholar-in-Residence is Dr. Samuel form the stalk of the fruiting body, while Dr. Barondes arrived at NIH Oct. 1. While Barondes, professor of psychiatry at the School others form spores. here, he is working with Dr. Ira Pastan in the of Medicine, University of California, San • They are species specific. There are many Laboratory of Molecular Biology, National Diego. species of cellular slime molds, but if you Cancer Institute, and with Dr. Victor Ginsburg Dr. Barondes, whose general research area combine several species and deprive them of in the laboratory of Biochemical Pharmacol­ is neurobiology, is ultimately interested in food, the fruiting bodies formed will each ogy, National Institute of Arthritis, Metabo­ how neurons interact to form pathways of contain only one species. lism, and Digestive Diseases. He says his cells. He is especially concerned with specific "We're interested in the code that deter­ discussions with NIH scientists have been molecules on cell surfaces that might mediate mines which cells bind to which cells," says "enormously helpful." cellular recognition, the process by which Dr. Barondes. His work with cellular slime Dr. Barondes plans to return to NIH cells form specific associations with only molds suggests that certain forms of cellular annually during the next 3 years for 3-month certain other cells. association may be mediated by the inter- periods to complete his Fogarty Scholarship.

Dr. Cornblath Named JFK Mem. Lecturer Dr. Marvin Cornblath, special assistant to the scientific director of NICHD, has been named this year's John Fitzgerald Kennedy Memorial lecturer of the Georgetown Uni­ versity Medical Center, department of pediatrics. Dr. Cornblath will speak on Neo­ natal Hypoglycemia- What's New on Its 20th Anniversary, on Nov. 16, at Gorman Audi­ torium, G.U. Medical Center. Early in his medical career, Dr. Cornblath became interested in endocrine and metabolic disturbances of children, especially in car­ bohydrate disorders in the newborn. Much of his research was focused on the special problems of these high-risk infants, including those born to diabetic mothers. Dr. Cornblath is coauthor with Dr. Robert Schwartz of a monograph, Disorders of Carbohydrate Metabolism in Infancy, which has become a classic reference for neo­ natologists. At NICHD, he coordinates the intramural research programs in the mechanisms, diag­ nosis, and treatment of certain metabolic disorders in infants and children. They also include endocrine disorders and inborn errors of metabolism, as well as the effects of such maternal conditions as diabetes and drug Reassurance is an important asped of the pediatric examination as Dr. Cornblath prepares lo addiction on the developing fetus. examine Dale Witzenberg, an NICHD patient, on Ward 9D of the Clinical Center.

November 13, 1979 The NIH Record Pages VISITING SCIENTIST CC Interpreters Make Unique PROGRAM Contribution to Patient Care PARTICIPANTS 10/9-Dr. Thorild Ericson, Sweden, National Caries Program. Sponsor: Dr. William Bowen, NIDR, Westwood Bg., Rm. 532. 10/9-Dr. Engin Gozukara, Turkey, Labora­ tory of Molecular Carcinogenesis. Sponsor: Dr. Harry Gelboin, NCI, Bg. 37, Rm. 3E24. 10/9-Dr. Jan S. Olsson, Sweden, Caries Prevention and Research Branch. Sponsor: Dr. William Bowen, NI DR, Park Bg. 5, Rm. 451-E. 10/9-Dr. Samuel Salzberg, Israel, Labora­ tory of Cell ular and Molecular Biology. Sponsor: Dr. Stuart Aaronson, NCI, Bg. 37, Rm. 1A07. 10/9-Dr. Yoshihiro Shidoji, Japan, Labora­ tory of Experimental Pathology. Sponsor: Dr. Luigi De Luca, NCI, Bg. 37, Rm. 2B26. 10/9-Dr. John W. Steele, Canada, Labora­ tory of Pharmacology. Sponsor: Dr. John R. Bend, NIEHS, Research Triangle Park, N.C. 10/9-Dr. Takashi Tsuchiya, Japan, Labora- tory of Molecular Biology. Sponsor: Dr. Terrell Hill, NIAMDD, Bg. 2, Rm. 317. 10/9-Dr. Pieter Van Jaarsveld, South Africa, Clinical Endocrinology Branch. Sponsor: Dr. Jacob Robbins, NIAMDD, Bg. 10, Rm. 8N315. 10/10--Dr. Stephen J. Karlik, Canada, Laboratory of Cellular and Molecular Biology. Sponsor: Dr. Gunther Eichhorn, NIA, Geron­ tology Research Center, Baltimore. 10/11-Dr. Sung K. Chang, Korea, Labora­ Mrs. Shepard explains a consent form to Maria de Souza, a CC patient from Brazil. tory of Biochemistry. Sponsor: Dr. S. I. Chung, NIDR, Bg. ~o, Rm. 114. They are not doctors, nurses, researchers, Patricia "Tish" Shepard is a Red Cross 10/11-Dr. Hiroshi Hamada, Japan, Labora­ or counselors. They are three women whose volunteer who has worked twice a week for 7 tory of Molecular Carcinogenesis. Sponsor: age and experience have led them to volun- years in the Cancer Surgery Clinic. In addition, Dr. Takeo Kakunaga, NCI, Bg. 37, Rm. 3E08. teer their services to "speak" for non-English- she has been on call as an interpreter when- 10/11-Dr. Seiichi Takasaki, Japan, Labora­ speaking Clinical Center patients. ever and wherever her services are needed. tory of Biochemical Pharmacology. Sponsor: The women are interpreters who work at She speaks Spanish, Portuguese, and French, Dr. Loretta Leive, NIAMDD, Bg. 4, Rm. 111. the CC. Every day their ability to quickly and all languages learned while living in Brazil, 10/12- Dr. Samuel Caplan, U.S., Laboratory accurately communicate medical instructions France, and Belgium as the wife of a U.S. of Theoretical Biology. Sponsor: Dr. Mones and basic human emotions is tested. From the Foreign Service Officer. Berman, NCI, Bg. 10, Rm. 4B58. time a non-English-speaking patient arrives at Mrs. Shepard's interest in volunteer hospital 10/12-Dr. Ryuichi Hasegawa, Japan, Labo­ the CC, it is the interpreters' role to help make work dates back to when she organized ratory of Biochemistry and Metabolism. the patient's transition to hospital routine as hospital volunteers in Brazil and Belgium.'She Sponsor: Dr. Frank Eisenberg, NIAMDD, Bg. easy as possible. says that it was "a sense of respect I have for 10, Rm. 9B07. Questions Often Difficult medicine and all aspects of it'' that prompted 10/15- Dr. Bakul Dalal, India, Laboratory of her to apply as an interpreter at the CC, and Toxicology. Sponsor: Dr. A. M. Guarino, NCI, Sometimes patients' questions are difficult, she also wanted to keep up her language Bg. 37, Rm. 5B22. particularly when there are no immediate or facility. 10/15-Dr. Arifa S. Khan, Pakistan, DNA satisfactory answers. Usually, upon their Recombinant Research Unit. Sponsor: Dr. arrival, patients want to know what their new A Rewarding Experience Malcolm Martin, NIAID, Bg. 5, Rm. 329. doctors are going to do for them and the 10/15- Dr. Stefano Ruggieri, Italy, Experi­ purpose of each test. Under the best of "I don't answer medical questions, but I mental Therapeutics Branch. Sponsor: Dr. circumstances, even when a patient and a refer them to the right source," says Mrs. Thomas Chase, NINCDS, Bg. 36, Rm . SA05. physician speak the same language, these Shepard when questioned about how she 10/15-Dr. Kamlesh Vyas, India, Laboratory questions are not easy. deals w ith patients. Sometimes being an of Bioorganic Chemistry. Sponsor: Dr. Donald As with other volunteer assignments, a interpreter can be physically taxing, as was the Jerina, NIAMDD, Bg. 4, Rm. 214. description of the job of "patient relations case when Mrs. Shepard went 5 hours without interpreter" outlines duties and requirements, a break, interpreting back and forth between but the work goes beyond what is normally a doctor and a patient during the recording required of someone who speaks a foreign of a family medical history. language. It fails to list the communicative Perhaps the most rewarding experience for skills needed to deal with people in a complex Tish Shepard came when she was call ed in research hospital environment. from home to interpret for a Spanish-speaking A CC interpreter must possess diplomacy patient who was undergoing hyperthermia for and stamina, and care for other people. The treatment of cancer. For 12 hours Mrs. Hliiiil interpreters have demonstrated these qualities. Shepard translated the medical staff's ques- (Continued on Page 7)

Page 6 The NIH Record November 13, 1979 (Continued from Page 6) they receive here." She points out that a good tions and the woman's answers. "It was an translator must be able to determine the level DR.ROTH honor to be with that team," she said. of sophistication of a patient and that this (Continued from Page 1) Last month the volunteer interpreters assessment helps to determine how she as a teacher of young scientists as well as a responded to a variety of patients from should relate to them and which level of researcher of world renown. The list of young Puerto Rico, Peru, Colombia, Ecuador, Barba­ vocabulary to use. investigators he has sponsored, all of whom dos, France, Quebec, and Italy, and nine Sometimes concern for patients even have gone on to productive and often out­ non-English-speaking American patients. extends to their off-duty hours for Mrs. Lerdau standing research careers, includes Ors. Gerald "We are never sure exactly when there and Mrs. Berkes. They have been known to Levey, David Taunton, Robert Lefkowitz, Gary might be a need for a particular language," exchange information about patient needs Robertson, Barry Sherman, Ira Goldfine, says Betty Schwering, director of volunteers over the telephone, so that whoever is work­ Pierre Freychet, James Gavin, Pierre De Meyts, and patient representatives, who keeps on file ing the next day can take care of them. Juanita Archer, C. Ronald Kahn, Andrew $QI!, a list of NIH employees and others who speak Robert Bar, Barry Ginsberg, Michele Muggeo, foreign languages and are available to help Encourages Cooperation and others. - interpret when a particular need arises for a "Every time I learn something new from the Dr. Roth's career began in the laboratories specific language. "Right now we need people patients and the doctors," says Mrs. Berkes of Ors. Solomon A. Berson and Rosalyn S. who can speak Rumanian and Farci (Persian)," about her experiences. She views her role as Yalow in New York City, where t,e and Dr. she says. helping the patients by "talking with them to Seymour M. Glick used various radioimmuno­ make them believe" that through their coop­ assay techniques to study human growth Patients' Families· Helped eration it w il l be easier to determine what is hormone. Her two regular interpreters, Lily Berkes making them ill. In 1966, Dr. Roth, in collaboration with Dr. and Barbara Lerdau, both of whom give 2 Mrs. Berkes, originally from Yugoslavia, Ira Pastan, published a pioneer work which days a week, are able to deal with tense speaks seven languages-French, German, pointed out some of the fundamental rules situations and help relatives understand a Hungarian, Italian, Serbo-Croatian, and that govern the interaction of insulin with its patient's condition. Spanish. Until 2 years ago, she lived in specific receptors on cells. "There's more need sometimes to talk with Madrid. the family than the patient . .. sometimes The facility to communicate in more than Method Measures Binding we are the only relief they have," says Mrs. one language has allowed these women to In 1969-70, Dr. Roth, in collaboration with Lerdau, who learned her English in school in make a unique contribution to medicine. Robert Lefkowitz, William Pricer, and Ira Germany before fleeing when the Nazi's took "These patients understand that there is a Pastan, introduced the first method to meas­ control. She went to Peru, where she raised generous spirit in this house, and that it is ure directly the binding of a hormone to its a family and later worked in an international translated into care and consideration," says specific receptors on the cell surface. This travel agency. Mrs. Lerdau, summing up her feelings and method has been applied widely, initially to Most of the patients she has dealt with at those of the other interpreters about why hormones, including insul in binding to its the CC are "extremely grateful for the care they volunteer to help CC patients. recepto rs, and subsequently to other biolog­ ically active materials that have eel I su rface receptors, such as lectins, toxins, neuro­ transmitters, lipoproteins, and microbial agents. In 1972, the first disease involving a cell surface receptor was identified by Dr. C. Ronald Kahn in collaboration with Ors. Roth, David M. Neville, Jr. (NIMH), and Pierre Freychet. Further, the investigators showed that cell surface receptors are highly regulated by many biologically important signals from both inside and outside the cell. From these early findings, Drs. Roth and Kahn, in collaboration with Dr. Phillip Gorden and others in the Diabetes Branch, progressed to the study and characterization of insulin receptor defects in human diseases, including obesity, diabetes, acromegaly, anorexia nervosa, lipoatrophic diabetes, and in other rarer disorders of insulin resistance. Since then, numerous diseases associated with defects in other cell surface receptors have been identified by other investigators in many laboratories.

Awards Recognize Research Mrs. Lerdau stressed the significance of tilking Mrs. Berkes, originally from Yugoslavia, Dr. Roth's position in diabetes-related with a patient's family. is fluent in seven languages. research has been recognized by numerous special lectureships and awards, including the Ernst Oppenheimer Memorial Award of the Endocrine Society and the Eli Lilly Award of Polypeptide Hormone Receptor Workshop Starts Today the American Diabetes Association. In 1977, he won the Juvenile Diabetes NCl's Breast Cancer Task Force Committee receptors, including hormone binding assays, Foundation's David Rumbough Memorial is sponsoring a 2-day Workshop on Polypep­ receptor interactions, action of hormones, Award for outstanding scientific achievement. tide Hormone Receptors in Normal and and clinical implications relating to breast In 1979, he shared with colleagues the Neoplastic Mammary Tissues in Bldg. 31, cancer in animals and humans. Berson-Yalow Award of the Society of Nuclear Conf. Rm. 10, starting at 9 a.m. today · All interested scientists and the public are Medicine and the Diaz-Cristobal Prize (Tuesday, Nov. 13). welcome. For more information, contact Dr. presented at the triennial meeting of the Speakers will discuss prolactin and insulin D. Jane Taylor, 496-6718. International Diabetes Federation in Vienna.

November 13, 1979 The NIH Record Page 7 TEMPERATURES Dr. Doszkocs Receives (Continued from Page 3) NLM Regents Award energy needs and heating systems. Contained in the law are automatic exemp­ For Tech. Achievement tions: hospital patient areas and examining rooms, computer areas, animal rooms, and Dr. Tamas E. Doszkocs has received the printing areas. Most administrative office areas National Library of Medicine's Regents Award will not be exempt. for Technical Achievement. The award, given Last year's average NIH office temperature in recognition of Dr. Doszkocs' technical was held between 68-70°F. Even with these creativity in developing two experimental warmer temperatures, some employees used on line bibliographic search tools, was portable electric heaters in their offices. presented at the Oct. 4 meeting of the Board Under the new legislation, use of portable of Regents. He is presently head of the electric heaters is prohibited. Library's Technical Services Division. Even though the new law lowers office While in NLM's Division of Specialized temperatures, it does not mean that all offices Information Services, Dr. Doszkocs developed will automatically have 65°F temperatures. an online dictionary that automatically gen­ Some offices will be over that limit, says erates and displays related terms, synonyms, Arthur E. Bonnet, Jr., chief, Maintenance Engi­ and other semantic associations for given Dr. Nicholas E. Davies (I), acting chairman of the NLM Board of Regents, joins the audience in neering Branch. "There are numerous factors search concepts. applause after presenting the NLM Regents such as internal heat load and system design This innovative searching tool-termed AID Award for TechnicaJ Achievement to that will influence an office's temperature, for Associative Interactive Dictionary-has Dr. Doszkocs. and perhaps result in temperatures over 65°F proven to be valuable in formulating search at times," he says. strategy for TOXLINE and several other data A D.O.E. Certificate of Building Compliance bases. in English), promises to help physicians, has been placed in the lobby of each NIH Dr. Doszkocs also developed a prototype researchers, and general users to search building. system for searching MEDLINE. This system, MED LINE and other data bases directly, using Employees who have questions about the known as CITE (Current Information Transfer their own terminology. new temperature restrictions can call: in Bldg. 10, 496-5862; buildings north of South Drive, 496-5083; buildings south of South Drive, Dr. Herman, DRS Microbiologist for 21 Years, Retires 496-6484; National Library of Medicine, 496-5441; and the Animal Ce11ter, Poolesville, Dr. Lloyd G. Herman, an environmental 496-9040. microbiologist with the Division of Research Services since 1958, retired recently. While at NIH, Dr. Herman developed OMS Offers Program on Aging techniques for sampling Clinical Center air The Later Years, a program on aging, will and surfaces for microorganisms, particularly be presented by OMS counselor Rachelle Staphylococcus and Pseudomonas, and iso­ Selzer on the following dates: lated and identified organisms in humidifying Tuesday, Nov. 13, 11 a.m., Bldg. 10, Masur units that were causing infections in heart­ lung surgical patients. Auditorium. He also developed techniques for isolating Wednesday, Nov. 14, 11 :30 a.m., West­ slow-growing pigmented water bacteria from wood Bldg., Conf. Rm. D. drinking fountains, dental rinse units, water Thursday, Nov. 15, 12:15 p.m., Federal baths, high-humidity incubators, and sur~ical Bldg., Rm. 8119. scrub sinks. Monday, Nov. 19, 11 :30 a.m. and 12:15 Dr. Herman, who was born in Canada, p.m., Bldg. 1, Wilson Hall. received a B.S.A. in agriculture from tlie University of Toronto and a Ph.D. in micro­ biology from McGill University in Montreal. Before coming to NIH, he worked as a microbiologist for the D.C. Health Depart­ ment and as a bacteriologist for two private Dr. Herman has lectured extensively in this firms, one in Chicago and one in New York. country and abroad, and has published more than Dr. Herman is one of the founders and a 30 papers on sanitation problems. charter member of the NIH Toastmasters.

History of Medicine Society To Meet Nov. 15 at NLM Two speakers, Dr. Frank Portugal and J. S. Cohen, co-author of the book, A Century Alexander Adler, will be featured at the next of DNA (Massachusetts Institute of Tech­ meeting of the Washington Society for the nology Press, 1977). History of Medicine on Thursday, Nov. 15, at Mr. Adler will speak on U.S. Naval 8 p.m. in the Billings Auditorium, National Hospital Ships; Selected Historirnl Vignettes. Library of Medicine. He is special assistant for Extramural Affairs, ., Dr. Portugal will discuss From Man to Office of the Administrator, Health Resources Silkworm: the History of the Department of Administrator. Mr. Adler has a special interest Arlene V. Simms, chief of the Inventory Manage­ Embryology at the Carnegie Institution of in U.S. naval history. ment Section, Supply Operations Branch, Materiel Management, DAS, retired recently after more than Washington. Parking is available at the side of the NLM 36 years of government service, 28 of them with He is presently on the Carnegie staff to Bldg. and also across Center Drive. the Supply Operations Branch. Traveling is part of prepare a history of that institution. Author The next meeting will be held Jan. 24, 1980. her future retirement plans. of some dozen research papers, he is, with For more information, call 496-5961.

Pages The NIH Record November 13, 1979 Books on Diseases of Liver, Other Reports Available at FIC Two recently published books on d iseases in development and marketing of medicinal of the liver and other publications of interest agents, and categorizes industrial or occupa­ to professionals are available at the Fogarty tional environments in relation to the use of International Center. hepatotoxic materials. Neonatal Hepatitis and Biliary Atresia is the This book, in conjunction with an earlier proceedings of an international workshop Fogarty publication, Diseases of the Liver and sponsored by NIAMDD and FIC. Biliary Tract: Standardization of Nomencla­ Dr. Norman B. Javitt edited the 459-page ture, Diagnostic Criteria, and Diagnostic volume, which summarizes existing knowl­ Methodology, provides a common language edge concerning the causes, recognition, and and standards that can be used throughout management of these diseases. Recommended the world by investigators and regulatory nomenclature and criteria for diagnosis are agencies concerned with liver damage result­ presented in the appendixes. ing from administration of drugs or from Guidelines for Detection of Hepatotoxicity exposure to environmental and industrial Due to Drugs and Chemicals reports a con­ chemicals. ference sponsored by the International Limited Proteolysis in Microorganisms, a Association for the Study of the Liver; Bureau report on biological function and its use in of Drugs, FDA; N IOSH; NIAMDD; NIEHS; protein structural and functional studies, and FIC. edited by two Fogarty scholars, D rs. Georges Edited by Drs. Charles S. Davidson, Carrol N. Cohen and Helmut Molzer, was published M. Leevy, and Earl C. Chamberlayne, the last summer. Dr. Louis Sokoloff, chief of the laboratory of 143-page book presents criteria for classifying These books are available to professionals Cerebral Metabolism, National Institute of Mental hepatotoxicity as one of two types, designates from the Fogarty Publications Office, Bldg. Health, recently delivered the Foster Elting Bennett four phases for evaluation of hepatotoxicity 16A, Rm. 205. Memorial Lecture at the 1979 meeting of the American Neurological Association in St. Louis. Dr. Sokoloff spoke o n the metabolic mapping of Career Education Center Offers Graduate Courses local functional activity in the central nervous system. In addition to his pioneering research, he In Administration on Campus has been guest lecturer in many countries abroad, including tl1e Royal College of Physicians in The NIH Career Education Center is for training as described in the NIH Training London, England. expanding the scope of the former Upward Policy (NIH Manual Issuance 2300-410-1). Mobili ty College, offering graduate courses Applications are being accepted from now in administration on campus. until Dec. 3. Each applicant must submit an Dental Care for PHS These fully accredited graduate level approved HEW Form 350 to the 8/1/D per­ Officers Available courses-Public Administration, Financial sonnel office, which will review these in Management, Computer Science, Adminis­ accordance with the NIH training policy, All active duty PHS commissioned officers tration of Science, and Personnel Administra­ determine priorities, and forward the stationed at NIH or the Parklawn Bldg. in tion- will be staffed and taught by full-time nominations list in rank order to the Career Rockville are eligible to receive comprehen­ faculty of American University Development Branch. That Branch will ensure sive dental care at the Commissioned Officers Twenty slots are available for each course, equitable distribution of training among Dental Clinic, Bldg. 31, Rm. B2B-34. which meets once a week for 2½ hours. B/I/D's. Information regarding appointments for Spring courses begin the week of Jan. 28 and Spring semester courses will be: Public examinations and dental care can be obtained end the week of May 5. Management, Public Personnel Administra­ by calling 496-2944/2484, Monday through To be eligible for nomination, an employee tion, Public Program Evaluation, Politics and Friday from 8:30 a.m. to 4 p.m. must have a career or career-conditional Contemporary Health Issues, and Computer appointment, have 12 months' continuous Applications. For additional information, con­ Federal service. possess a bachelor's degree tact your personnel office or the Career ASPA Will Hold and meet the job-related requi rements Development Branch, 496-6211. Annual Conference Dec. 6, 7 Genetic Diseases Topic of Tonight's Lecture The National Capital Area Chapter of the American Society for Public Administration will hold its 10th annual conference on In Medicine for Layman Series Dec. 6 and 7 at the Capital Hilton Hotel in The Medicine for the Layman lecture On Tuesday, Nov. 27, Dr. Arthur Nienhuis, Washington, D.C. tonight (Tuesday, Nov. 13) on Control and NHLBI, will discuss Sickle Cell Anemia and The theme of the conference will be Hold­ Therapy of Genetic Diseases will be pre­ Thalassemia. His lecture will cover these two ing Federal Administrators Accountable­ sented by Dr. Roscoe Brady, chief, Develop­ genetic disorders that affect red blood cells, Policies and Processes. Elmer Staats, Comp­ mental and Metabolic Neurology Branch, and current research and new therapies. troller General of the U.S., and Senator Charles McC. Mathias, Jr., (R-Md.) will be the NINCDS. His talk is based on research that he At the final Medicine for the layman keynote speakers. has conducted on a group of genetic disorders lecture, on Dec. 4, Dr. Robert Chanock, The registration fee-which includes called lipid storage diseases. His discoveries NIAID, will discuss Viruses. Dr. Chanock, lunch- is $75 for members, $90 for non­ in this area have lead to the experimental chief, NIAID's Laboratory of Infectious Dis­ members, and $30 for full-time students. management of some of these disorders eases, will speak on viral diseases and their through enzyme replacement. For further information call George impact on populations of the world. He will Bickerton, (301) 436-8051. On the following Tuesday, Nov. 20, Dr. focus on respiratory and gastrointestinal Marvin Cornblath, National Institute of Child diseases and viral hepatitis. Health and Human Development, will discuss Nutrition: Infancy Through Adolescence. All lectures are at 8 p.m. in the Masur C0'181NED Dr. Cornblath's research centers on special Auditorium, and are open to the public. FEDERAL problems caused by carbohydrate disorders For further information, please contact the CA'1PAIGN in infants. His talk will touch on how people's Office of Clinical Reports and Inquiries at HHiiil 0FnEN.<11101W.CN'IIN.- nutritional values change as they mature. 496-2563.

November 13, 1979 The NIH Record Page 9 NIH Golf League Winds Up Its 1979 Season Grocery Groups Crop Up In Midwest Robert Seward; Low Gross, C Flight, Hazel Several reincarnations of the Grocery Hinds; Low Net, A Flight, Tina Chisena; Low Group-NI H's singing, dancing, nutrition Net, B Flight, Bernice Kraker; and Low Net, message that first appeared at HEalthWorks C Flight, Bertha Lecompte. on the Mall this summer-were spotted re­ Winning Teams- A Flight, Aber, Chicchiri­ cently in the midwestern United States. chi, Chisena, Hamilton, Jenson, Jones, Nylen, In response to three congressional requests, Percy, Sears; B Flight, Aud, Bailey, Boak, Tom Flavin, the NIH News Branch editor who Duggan, Kraker, Reed, Sweitzer, Wilson; and conceived and organized the group, took the C Flight, Caruso, Evans, Hinds, Lecompte, Grocery Group costumes and script to St. Sanslone, Walson. Louis; Milwaukee; and East Chicago, Ind., Captains Receive Awards where he recruited and directed volunteers to perform in health fairs. Officers' Recognition Awards-president, "In each city, I had to find 18 mildly insane Constance Percy; secretary, Marie Nylen; people to get into the costumes and teach treasurer, Anne Proctor; and scorer, Toni them the lyrics and choreography," he said. Dunlap. In Milwaukee, he recruited the singing fruits Captains' Awards-Ann Horn, Alice San­ and vegetables from a hospital, mostly the Recognition awards were presented at the Coif slone, Fran Boak, Rose Shreiber, Jean Russell, League banquet to 1979 officers. L to r are: emergency room staff; the St. Louis group was and Mary Sears. selected from the Webster College drama Constance Percy, Anne Proctor, Toni Dunlap, and Special Achievement Prizes- Aber, Browne, Marie Nylen. department; and the East Chicago performers Duggan, Gill, LeCompte, J. Russell. were members of a parish theater group. The NIH Golf League (formerly the NIH During a short business meeting, the Mr. Flavin even recruited three actresses Women's Golf Association) closed the 1979 members approved amendments to the while shopping in a St. Louis health food season last month with an awards banquet. constitution and bylaws, and election results store. "I was talking to the two young Lois Duggan, who chaired the Awards for 1980 officers were announced: president, daughters of the owner, and they told me Committee, presented the following: Nancy Cahill; secretary, Ann Horn; treasurer, they had been in a school play recently and Trophy Winners-Low Gross, A Flight, Jean Russell; and scorer, Mary Sears. had a beet costume and a cucumber cos­ Dave Chicchirichi; Low Gross, B Flight, The 1980 season of the R&W-sponsored tume," he recalled. "So I worked them into Golf Leagu e will open with an organizational the Grocery Group. They made a cherry meeting early in the year. costume for a third sister, and she joined, NIH LECTURE too." (Continued from Page 1) for the control of gene expression. In the course of this work, D r. Gilbert developed several ingenious new methods for probing in detail the structure of DNA-protein complexes, including a new technique for determining DNA sequence. The DNA sequencing methods available at the time Dr. Gilbert first analyzed DNA were laborious. By combining his knowledge of chemical modification of DNA with novel methods for separating DNA fragments, Dr. Gilbert devised a method for DNA sequence determination that was much faster and easier than earlier techniques. Total DNA Sequence Determined This method made it possible to determine the total sequence of large DNA molecules. Previously it had been a major task to deter­ .(f mine a sequence 30 bases long. It is now almost routine to learn the entire DNA • ..i.l_ --- sequence of a virus or plasmid containing Grocery Croup "Tomato" Margie Riffenbark, a. Webster College drama student, sings about good 5,000 base pai rs. This revolutionary develop­ nutrition to patients at the St. Louis Shriner's Hospital. ment has enabled scientists to think about the multiple functions of DNA molecules with a richness of detail undreamed of before. Hear Tapes on Personnel Topics Columbia Commuter Bus Service May Expand Dr. Gilbert received an A.B. degree from CALL 496-4608 to hear recorded telephone Harvard College in chemistry and physics, an tapes on personnel topics. The schedule is: A.M. degree from Harvard University in The Columbia, Md. Route 29 to physics, and a Ph.D. degree from Cambridge Date Topic NIH/Bethesda commuter bus service, now in University in mathematics. After completing a Nov. 12-18 Probationary Period for First­ the fifth year of operation, may be expanded National Science Foundation postdoctoral Time Managers and Super- to include a second bus to arrive at NIH fellowship in physics at Harvard in 1958, he visors before 8 a.m. and depart about 4:30 p.m. The taught physics, biophysics, and biochemistry Nov. 19-25 Injured on the Job present bus arrives at 8:15 a.m. and departs there until 1972, when he was named the Nov. 26-Dec. 2 Graduate Courses in Admin­ at 5 p.m. American Cancer Society Professor of istration In order to determine the need and Molecular Biology. Dec. 3-9 Appointments and Appoint­ advantage of a second bus, all who are Dr. Gilbert has won numerous awards, ment Authorities interested should call: Dick West, 496-3113, fellowships, and lectureships. Dec. 10-1 6 Stride or Ann Dieffenbach, 496-1752.

Page 10 The NIH Record November 13, 1979 Dr. Sharon Johnson Joins Research Allowing Scientists To View Brain Grants Associates Program In Action Funded Through NINCDS Dr. Sharon L. Johnson, formerly associate professor of chemistry with the Polytechnic Institute of New York, has joined the Grants The National Institute of Neurological and technique at this early stage of development Associates Program for a year of training Communicative Disorders and Stroke has because it is too expensive and complicated. in health science administration. awarded $5.7 million to expand research on a "But it is going to allow us to do extraordinary Dr. Johnson was new technique using a radioisotope and a things in research, things we have never been principal investi­ scanning device that allows neuroscientists to able to do before," he added. gator on three watch the human brain in action. The technique is significantly different from research grants sup­ The technique is called positron emission the computerized axial tomography (CAT) ported by the Na­ transverse tomography (PETT). scanners now well known in d iagnostic medi­ tional Institute of A patient being studied by PETT is injected cine. The CAT scan takes a still picture of the General Medical with or inhales a biochemical such as glucose, structure of an organ, allowing physicians to Sciences. She also ammonia, o r oxygen that has been tagged see abnormalities. PETT displays chemical has received re­ with a short-lived radioisotope. The radio­ activity within the brain as the activity occurs. active tag emits positrons, charged particles search support from "What CAT scans have done for our ability detectable by a computerized imaging device. the National Sci­ to visualize the anatomy and structural pathol­ A scanning detector then follows the tagged ence Foundation. ogy of the intact brain, PETT promises to do Or. Johnson She has served as compound's progress through brain tissue. Chemical activity is displayed on a TV screen w ith respect to brain metabolism and func­ a referee for the tion," said Dr. Tower. Journal of the American Chemical Society, as a grid of color patterns, much like a The institutions and principal investigators the Journal of Organic Chemistry, and the patchwork quilt. who received the grant awards are: Canadian Journal of Chemistry; as a con­ " PETT will allow researchers to observe patterns of chemical activity that take place in • Dr. Martin Reivich sultant to Ebon Research Systems, Inc., on University of Pennsylvania prepared reports for the Environmental the brain during speaking, hearing, and • Dr. Henry Wagner, Jr. Protection Agency; and as a member of an thinking; to evaluate changes in brain chem­ The Jo h ns Hopkins University istry before, during, and after a stroke; and to • Dr. Alfred Wolf NIH ad hoc study section. Brookhaven National Laboratories determine the response of a brain tumor to • Or. Alan Lockwood Education Noted drug treatment," said Dr. Donald B. Tower, University of Miami School of Medicine • Dr. David Kuhl Dr. Johnson received a B.S. degree from NINCDS Director. "With PETT we will also be University of Cal ifornia, Los Angeles Iowa State University in 1955 and the Ph.D. able to see the process of formation of brain • Dr. Jerome Posner degree in physical organic chemistry in 1959 lesions in multiple sclerosis and probe for Sloan-Kettering Institute of Cancer Research from the Massachusetts Institute of Tech­ biochemical abnormalities in disorders such Earlier studies supported by NINCDS grants nology. From 1959 to 1965, she was an as Huntington's disease or Alzheimer's are already under way at Washington Univer­ independent fellow in fundamental research disease." sity in St. Louis and at Massachusetts General at Mellon Institute. Dr. Tower said that PETT is not a diagnostic Hospital in Boston. Dr. Johnson then became associate professor at Vassar College until 1966 when Deadline for STEP Module she joined Westinghouse's Research and Development laboratories as a senior chem­ Extended to Dec. 11 ist. The following year, she served as assistant The deadline for applying for the 1-day professor of biochemistry at the University of STEP module, Program Evaluation for Rational Pittsburgh School of Medicine, then, in Choices, has been extended to Dec. 11. 1978, joined the faculty of the Polytechnic The course, which will be held Feb. 12 at Institute of New York. NIH, will introduce participants to the process of evaluating scientific programs in order to Booklet Gives Useful Tips set priorities and make the best use of resources. On Stretching Gas Dollar Dr. John T. Kalberer, Jr., assistant director Have gas lines and gas shortages tempted of the Office for Medical Applications of you to fill up a gas can and store it in your Research, will direct the module, which is car trunk/ Don't. One gallon of gas stored in designed for persons who manage and plan the trunk of your car has the explosive power scientific programs. of 14 sticks of dynamite. Application forms (NIH-2245) should be How can this happen? According to the sent to the Special Programs Office, Bldg. 1, U.S. Consumer Product Safety Commission, Rm. 211. Fo r further information, call Arlene the danger is in the fumes. Bowles, 496-5358. Drastic temperature changes in the trunk of your car can cause the gasoline to expand, Reminder: Tickets Available which in turn causes pressure in the can and For R&W Events leaking fu mes. Then a mere spark from a short in a tail light or a rear end collision could Tickets are still available for events spon­ cause the explosion. Believe it or not, these sored by the NIH R&W Association. vapors, which are invisible to the naked eye, Chinese acrobats from Taiwan will perform can travel up to 30 feet from the source-and at the Warner Theater on Wednesday, Nov. this can happen in your car trunk, your home, Prevent Fires-Save Lives!! 21. Orchestra seats are $9.90. or at the gas station. "Daisy Mayme," starri ng Jean Stapleton, The CPSC reports over 569 fatalities from will be at the Kennedy Center Nov. 28. igniting gasoline si nce 1973, and more than tips on stretching the gasoline dollar, send Orchestra seats are $13.50. 4,300 injuries from gasoline-re lated burns in for the free Department of Energy booklet, Noel Coward's "Design for livi ng" will be 1977. Tips for Motorists, by writing to the Con­ at the Arena Stage on Wednesday, Dec. 5. The best way to store gas is in the tank of sumer Information Center, Dept. 519G, Bus transportation is included in the ticket your car- by using less of it. For some useful Pueblo, Colo. 81009. price of $12.50.

November 13, 1979 The NIH Record Page 11 Dr. Sever Wins Kimble Methodology Award Dr. Billingham To Deliver Dr. John Sever, chief of the Infectious Next Kinyoun Lecture Diseases Branch, National Institute of Neuro­ Dr. Rupert E. Billingham will deliver the logica l and Communicative Disorders and fourth in a series of Kinyoun Lectures, spon­ Stroke, has received the 28th Kimble sored by the National Institute of Allergy and Methodology Award. Infectious D iseases, on Tuesday, Nov. 27, at The $1,000 award recognizes Dr. Sever's 4 p.m. in Bldg. 1, Wilson Hall. work in developing a micro method to study He will speak on Transplantation Experi­ blood and blood components, and his devel­ ments in Nature and Their Biological opment of diagnostic procedures and viral Significance. reagents now used worldwide. Dr. Billingham, professor and chairman oi Dr. Sever's micro technique reduces the the department of cell biology at the Uni­ amount of fluid scientists need to measure versity of Texas Health Science Center at concentrations of various substances, and Dallas, is a pioneer in the study of transplan­ enables laboratories to run up to 96 tests, tation immunology. previously requiring one test tube each, on The series honors Dr. Joseph J. Kinyoun, a single 4"x6" plastic plate. who established the infectious disease The award, made jointly by the Conference research laboratory that evolved into NIH. of Public Health Laboratory Directors and the Dr. Sever was honored for his development of a Kimble Products Division of Owens-Illinois, micro method for studying blood and blood Inc., was presented to Dr. Sever at a banquet components. held in New York City Nov. 4. Public Gets 60 More Days To Comment On Ethics Advisory Board Report HEW will give the public an additional 60 reached two major conclusions: first, that days to comment on the report of the Ethics HEW " . . . should consider support of care­ Advisory Board concerning Department fully designed research involving in vitro support of research involving human in vitro fertilization and embryo transfer in animals, fertilization and embryo transfer. including non-human primates, in order to The Report and Recommendations were obtain a better understanding of the process published in the Federal Register on June 18, of fertilization, implantation, and embryo 1979. development, to assess the risks to both The additional comment period allows the mother and offspring associated with such public an opportunity to review an appendix, procedures, and to improve the efficacy of not available through the U.S. Government the procedure ..." and second, providing Printing Office until after the first comment that several conditiqns are met, as discussed period ended Aug. 17. The appendix contains in detail in the report, that it is " ... accepta­ papers p repared for the Board by scholars ble from an ethical standpoint for the in the fields of reproductive science, ethics, Department to support or conduct research Dr. Billingham's interests are in mammalian theology, law, statistics, and social policy. involving human in vitro fer.tilization and reproductio n as a form of successful natural The additional comment period, which embryo transfer ..." transplantation. begins with publication of a notice in the Since all previous comments are on file, Nov. 9, 1979, Federal Register, ends on Jan. only new or amended comments need be Volunteers Needed for Trials 8, 1980. HEW Secretary Patricia Roberts submitted. On Potency of Hepatitis B Harris will then consider all public comments before deciding whether HEW should, in Written comments should be sent to the Virus Vaccine Office for Protection from Research Risks, fact, support research on in vitro fertilization Volunteers are needed for ongoing potency NIH, 5333 Westbard Ave., Rm. 3A-18, involving humans. trials of an inactivated hepatitis B virus vaccine. Bethesda, Md. 20205, on or before the Jan. Based on its extensive study of the medical, Safety tests of this hepatitis B vaccine lot have ethical, legal, and social implications of in 8, 1980, deadline posted in the Federal been completed in chimpanzees and humans, vitro fertilization, the Ethics Advisory Board Register in order to receive full consideration. and tests of the potency of sublots of the vaccine are now under way. The vaccines are safe and considerably more Combined Federal Campaign potent than other hepatitis B vaccines Still Accepting currently being tested elsewhere. Antibody to hepatitis B surface antigen Donations elicited by vaccines of this type has been shown to protect against type B hepatitis in When the Combined Federal Campaign extensive studies in chimpanzees. Efficacy begins each fall, we are all asked to think trials of similar vaccines are currently in prog­ beyond our personal problems and consider ress elsewhere in individuals who are at high those less fortunate than we. risk of natural exposure to hepatitis virus. Four weeks after the kickoff, many em­ A more extensive evaluation of the potency ployees have yet to make their pledge-­ of the NIH hepatitis B vaccine is about to either through a one-time cash contribution begin. Anyone interested in participating in or through a payroll deduction. Please tell this study is invited to call Dr. Vincent your keyworker that you wish to make a McAuliffe or Dr. Robert Purcell, 496-6227. contribution. BE A GOOD NEIGHBOR

OPEN YOUR HEART AND GIVE -tc{J.S. GOVERNMENT PRINTING OFFICE: 1979-311-203/ 5

Page 12 The NIH Record November 13, 1979