Nippon Kayaku Co., Ltd. Corporate Information

NIPPON KAYAKU BUSINESS STYLE Nippon Kayaku Co., Ltd. Corporate Information

Web site

Nippon Kayaku Co., Ltd.／Meiji Yasuda Seimei Building 19th and 20th Floors, 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 100-0005, Japan Web site: https://www.nipponkayaku.co.jp/english/ 2020.10 Message from the President

For more than 100 years since its establishment in 1916, Nippon Kayaku has developed products to meet the needs of the time by utilizing, combining and transforming our core technologies in the company’s main areas, explosives, dyes, pharmaceuticals and resins.

We aim to prove worthy of the trust of all our stakeholders by implementing CSR management with the goal of realizing our corporate vision, the KAYAKU spirit, "Continuously providing society with the best products through ceaseless progress and the combined forces of our consciences." At the same time, we will contribute to the realization of a sustainable society through our four businesses, functional chemicals, pharmaceuticals, safety systems and agrochemicals.

Going forward, we aim to tackle new challenges by working as one and employing our global "sukima" ideas. Our goal is to create a prosperous and more enjoyable future! So expect NipponFrom Kayaku“Sukima” to continue to the toWorld provide and the Future the best products and services going forward.

Our technologies, born from

“global‘Sukima’ ideas,” may not always

get a lot of attention.

However, these technologies support today’s “Global‘sukima’ ideas” is Nippon Kayaku’s lifestyles and various industries and are laying Corporate Slogan. The term“sukima” is Japanese for “niche,” meaning a place whose value is still a path to the future. undiscovered and unexploited. At Nippon Kayaku, our

Count on the Nippon Kayaku Group to continue aim is to be No. 1 globally in niche markets, not by virtue of scale, but by using our original technology to bringing forth supporting technologies fromPresident“sukima” provide high added-value products that the world needs. to contribute to the world and the future.

2101 NIPPON KAYAKU BUSINESS STYLE Message from the President Corporate Vision

For more than 100 years since its establishment in 1916, The KAYAKU spirit represents Nippon Kayaku Group's corporate Nippon Kayaku has developed products to meet the needs of the time by utilizing, vision - the ultimate goal of all its corporate activities. combining and transforming our core technologies in the company’s main areas, We fulfill our social responsibilities as part of our corporate efforts to realize explosives, dyes, pharmaceuticals and resins. the KAYAKU spirit. These efforts are based on the standards of conduct articulated in the Group Action Guidelines and in the Nippon Kayaku Group We aim to prove worthy of the trust of all our stakeholders by implementing CSR Charter of Conduct and Code of Conduct. management with the goal of realizing our corporate vision, the KAYAKU spirit, "Continuously providing society with the best products through ceaseless progress and the combined forces of our consciences." At the same time, KAYAKU spirit CSR Management Group ACTION Guidelines we will contribute to the realization of a sustainable society through our four businesses, “Continuously providing For the Nippon Kayaku Group, At Nippon Kayaku Group, we functional chemicals, pharmaceuticals, safety systems and agrochemicals. society with the best products CSR-based management believe in doing more than through ceaseless progress means aiming to realize the just going through the and the combined forces of KAYAKU spirit and being a motions of our work. When we Going forward, we aim to tackle new challenges by working as one and our consciences.” is the “good and strong company” to act, our aim is to think about Nippon Kayaku Group’s fulfill our social, economic and the value we each individually employing our global "sukima" ideas. KAYAKU spirit. environmental responsibility. contribute. Our goal is to create a prosperous and more enjoyable future! So expect NipponFrom Kayaku“Sukima” to continue to the toWorld provide and the Future the best products and services going forward. Corporate Vision KAYAKU Goal of corporate spirit activities Continuously providing society with the best products through ceaseless progress and Our technologies, born from Corporate vision the combined forces of our consciences.

“global‘Sukima’ ideas,” may not always Corporate activities

Business plans and get a lot of attention. business activities, CSR management action plans, However, these technologies support today’s activities that contribute to Corporate activities to society and local communities, realize the KAYAKU spirit activities that reduce lifestyles and various industries and are laying environmental impact a path to the future. Nippon Kayaku Group Charter of Standards of Conduct and Code of Conduct conduct Group Action Guidelines Count on the Nippon Kayaku Group to continue Policy on attitude and conduct bringing forth supporting technologies fromPresident“sukima” to contribute to the world and the future.

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会社案内英語_本文_2020.indd 2 2020/09/16 10:0 Supporting Everything from As we seek to be No. 1 globally in niche markets, Nippon Kayaku

sees functional chemicals, pharmaceuticals and safety systems as

People’s Lifestyles to Industries. growth industries and runs its business with “global ‘sukima’ ideas.”

Functional Chemicals Safety Systems Business Business Nippon Kayaku has a long history in With the combined efforts of our the development and manufactur- Group companies, we aim to con- Pharmaceuticals Business ing of explosives and pyrotechnic tribute to the creation of a "Super devices, together with a wide range Smart Society" and achieving We specialize in cancer-related of technologies. By applying these "SDGs" through the application and products, putting our many years of technologies, we have developed integration of our resin, colorant, development and manufacturing original automobile airbag inflators, Agrochemicals Business catalyst and optical processing know-how to work to handle prod- micro gas generators that tighten and Other technologies in order to globally ucts from new pharmaceuticals to seatbelts in the event of a collision, provide distinctive functional generics and provide medical insti- and ignition devices called squibs Nippon Kayaku runs agrochemical chemicals to areas including infor- tutions with the reliable informa- that are a key component of these. and real estate businesses. Sup- mation and communication, digital tion they need about anti-cancer We contribute to enhancing safety porting agricultural development printing, energy and resource con- drugs. Moving forward, "Speciality, in automobile societies by providing and production of high-quality servation and sensing. Biosimilar & Generic" will continue such products to the global market. food.Nippon Kayaku has been to be a key domain. We aim to developing, manufacturing, and contribute to society through selling the agrochemicals chemicals improved medical care by promot- (pesticides, herbicides, and soil ing innovations in our proprietary fumigants) that are essential for technologies and by providing a maintaining a stable supply of stable supply of and information food, the pesticides for killing about high-quality pharmaceutical insanitary insects, etc. products.

03 NIPPON KAYAKU BUSINESS STYLE NIPPON KAYAKU BUSINESS STYLE 04

会社案内英語_本文_2020.indd 2020/09/16 10:0 Supporting Everything from As we seek to be No. 1 globally in niche markets, Nippon Kayaku

sees functional chemicals, pharmaceuticals and safety systems as

People’s Lifestyles to Industries. growth industries and runs its business with “global ‘sukima’ ideas.”

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会社案内英語_本文_2020.indd 2020/09/16 10:0 Functional Chemicals Business ■Functional Materials Business

Epoxy resins and hardeners for encapsulation of semiconductor device Epoxy resins and hardeners for printed circuit board UV-curing resin for solder mask

In our functional materials business, we provide materials with various functions, such as epoxy resins that serve as an insulating material for semiconductor encapsulation, UV-curable resins used in various fields such as color resists, solder masks and hard coat- ings, and maleimide resins, with high heat resistance and low trans- mission loss, used in circuit boards for “5G” next generation mobile Supporting Society and Industry communication systems. Epoxy resin In addition, we also develop high value added products for use in a Within our functional chemicals business we handle functional materials, color wide range of fields. These products include formulated resin com- materials, catalysts and Polatechno products. Functional materials cover a va- posites such as Sealants for LCD, Sealants for LED, Photoresists and riety of functions especially for the electronics field, including epoxy resins, Insulating materials for micro electro mechanical systems (MEMS) UV-curable resins and other resin materials. Color materials include dyes for that combine our proprietary resins with structuring technologies, various optical films for light control and management. In addition, textiles and paper, color materials with high added-value, such as colorants we also offer a line-up of cleaning agents and chemicals (develop- for inkjet printer inks. Products from our catalyst business are used for the ing solutions, bulk removers and residue removers) used for pro- Sealants for LCD panels production of acrylic acid and methacrylic acid. Polatechno products include ducing LCD panels (color filters) and semiconductors. polarizing films, inorganic polarizers and components for X-ray analyzers. With this blending of new and long-established technologies, we create products designed to contribute to the creation of a "Super Smart Society" and achieve- “Sukima” of tomorrow: Maleimide resins ment of "SDGs." Maleimide resins, newly developed by our Functional Chemicals R&D Laboratories, are Rediscovering our roots: 1916 highly heat resistant and able to reduce trans- mission loss, which allow them to contribute Since the launch of the first full-color inkjet printers in the to the realization of the "5G" high speed, high early1990s, many types of dyes and pigments have found use as capacity mobile communication system. Cur- inkcolorants. With our lineup of numerous products and our colo- rently, maleimide resins are used more and rant synthesizing technology (backed by over 100 years of history more in the main circuit boards for next-gen- since Teikoku Senryo Seizo Co., Ltd. was founded in1916), we have eration smartphones and server, base stations. developed outstanding colorfast water-soluble dyestuff for inkjet photo printing and developed pigment slurry using new dispersion technology as we continue to advance inkjet technology.

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会社案内英語_本文_2020.indd 5 2020/09/16 10:0 Functional Chemicals Business ■Functional Materials Business

Epoxy resins and hardeners for encapsulation of semiconductor device Epoxy resins and hardeners for printed circuit board UV-curing resin for solder mask

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会社案内英語_本文_2020.indd 6 2020/09/18 22:50 ■Color Materials Business ■Polatechno products

Nippon Kayaku is pursuing the possibilities of dyes. As Japan’s largest We manufacture and market polarizing films used in LCD displays, touch dye manufacturer, we are always at the forefront of the industry. To panels and LCD projectors, along with retardation films, inorganic polarizers, meet the needs of customers, which change with time, we develop and components used in portable characteristic and unique dyes, including those that are vivid in color, X-ray analyzers. those that do not fade (colorfast) and those that are easy to handle. We The dye-type polarizing films are deliver a wide range of products to market, including textiles, paper, ideal for niche markets that demand resin coloring, and inkjet printers. a great deal of durability, such as Components for LCD projectors The company is committed to the creation of materials with features automobiles and LCD projectors. Polarizing ﬁlm that can contribute to society in a variety of areas. This is done by utiliz- ■Nippon Kayaku in your life ing Nippon Kayaku's printing and optical evaluation technologies, Dyes for papers including resisting, dispersion, and synthesis technologies developed over many years in its colorant business. These consist of various functional coloring materials such as infrared absorbing agents, color resists

for image sensors, pigment derivatives (synergists), Materials for ther- Curtains

mal paper such as overcoat agents, and developer. Printers

Projectors Dyes for Textiles Cell phones

Digital cameras Colorants for inkjet printers PCs

■Catalysts Business Stick-on notes Nippon Kayaku has been developing, manufacturing, and selling catalysts for the production of acrylic acid and methacrylic acid (by direct oxidation method). These products have been highly rated by our customers. Acrylic acid finds use as raw material in the production of SAPs (super absorbent poly- PCs Cell phones Printers Digital cameras Semiconductor encapsulator When liquid crystals are Durable dyes are used to Resist inks, which are mers) used in disposable diapers, etc., acrylic paints for automobiles, and adhesives. epoxy resin is used to protect, injected between sheets of color the ink for color UV-curing resins, are used in Methacrylic acid is used in FPDs, light-guide plate and other insulate and keep moisture glass, sealants for LCD panels inkjet printers. digital camera image sen- away from the semiconduc- are used as adhesive holding sors. optical applications, as well as in products such as transpar- tors of PCs and other elec- the glass together. ent plastics used for giant aquarium tank, automotive parts, tronic and information equipment. and artical marble. Projectors Stick-on notes Curtains Aquarium tank Substances like iodine and dyestuffs are caused to adsorb and Our dyes are used to make Dyestuffs are used that make orient themselves in polyvinyl alcohol. The resulting polarizing colorful paper. fibers, resins and other mate- film is used to allow light of only a certain direction to pass. rials colorful.

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会社案内英語_本文_2020.indd 2020/09/16 10:0 ■Color Materials Business ■Polatechno products

Projectors Dyes for Textiles Cell phones

Digital cameras Colorants for inkjet printers PCs

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会社案内英語_本文_2020.indd 8 2020/09/16 10:0 Pharmaceuticals Business ■Principal pharmaceutical fields

●Ethical drugs for Japanese use

Nippon Kayaku’s efforts towards cancer treatment have provided numerous products since the launch of BLEO™. A large lineup of cancer-related products and accumulation of information as well as know-how are our strong points. In the cancer-related field, we aim to contribute to society through improved medical care by promoting innovations in our proprietary technologies and by providing a stable supply of and information about high-quality pharmaceutical products. We do this by sta- tioning cancer-specialist medical representatives throughout Japan, setting up Medical Information Service Centers, where we respond to inquiries from medical professionals and others, and preparing a framework that can Supporting modern medical care deliver information to medical institutions about correct drug use for assisting in medical treatment.

Nippon Kayaku's history in the anti-cancer field started with the launch of BLEO™ in 1969, and currently has many anti-cancer line-up. On the basis of Nippon Kay- aku's network of cancer-specialist medical representatives, highly reliable informa- ●Biosimilars tion can be rapidly provided to physicians, pharmacists and nurses at clinical institu- Nippon Kayaku aims to make further contributions to tions. In recent years, we have been furthering our efforts into the areas of patients, their families, and healthcare professionals biosimilar products, generic anti-cancer drugs, as well as interventional radiology through the rapid commercialization of biosimilar pharmaceuticals, which are playing a major role in the treat- (IVR) so that we can continue to provide highly necessary pharmaceuticals and ment of cancer and Autoimmune disease. By providing a medical equipment for patients along with exceptionally reliable information to the wide range of biosimilars, the company hopes to help realize a society where everyone has access to high quali- medical institutions. ty medical care, at any place and time. Moving forward, "Speciality, Biosimilar & Generic" will continue to be a key domain. We aim to contribute to society through improved medical care by promoting innovations in our proprietary technologies and by providing a stable supply of and information about high-quality pharmaceutical products.

Rediscovering our roots: 1931

Yamakawa Seiyaku Co., Ltd. was founded in 1931 for the purpose of aspirin manufacture, and became an important company. At that time, aspirin was imported, but the Japanese government urged domestic manufacture of a number of important drugs, among which demand was greatest for aspirin. In 1933, Yamakawa Seiyaku Co., Ltd. succeeded with domestic manufacture, and Yamakawa aspirin tablets were launched. In 1943, Yamakawa Seiyaku Co., Ltd. merged with Nippon Kayaku Seizo Co., Ltd. to form Nippon Kayaku Co., Ltd.

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会社案内英語_本文_2020.indd 9 2020/09/16 10:0 Pharmaceuticals Business ■Principal pharmaceutical fields

●Ethical drugs for Japanese use

Rediscovering our roots: 1931

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会社案内英語_本文_2020.indd 10 2020/09/16 10:0 ■Principal pharmaceutical fields

“Sukima” of tomorrow: Polymeric micelle anti-cancer drugs

●Active Pharmaceutical Ingredients (API) and Export Business Polymeric micelle anti-cancer drugs have been developed with the aim of achieving suffi- cient efficacy and reducing adverce events by selectively concentrating in cancer tissues. We are conducting contracted manufacturing of pharmaceutical API and inter- It is a novel nanomedicine drug-delivery system (DDS) . mediates, using manufacturing techniques for high potency substances that were developed through fermentation technology and anti-cancer drugs as our API business. In addition, we are exporting anti-cancer drugs, including BLEO™ to over the world globally in regions such as Europe, Russia and CIS countries as well as Asia. Polymeric micelle anti-cancer drugs

Core: Anti-cancer drug 20 to 100 to nm 20 ●Diagnostic drugs

Nippon Kayaku provides diagnostics pertaining to tumor markers, which are useful for diagnosing cancer and judging the therapeutic effects and prognoses in the pharmaceuticals business. Nippon Kayaku also produces and sells blood sugar control markers (GlycoMark) used for diabetes. This product has been Amphipathic approved by the U.S. Food and Drug Administration (FDA) and are used in Shell: Amphiphilic foreign countries. block copolymer Nippon Kayaku has been deploying its business all over the world.

Sequence in drug-delivery system

food quality, which curb the growth of mold and microbes, cleaning disinfec- Escape from blood vessel tants, which sanitize food manufacturing environments, and raw materials for health food products. We are aiming to contribute to the society with our products and services for food safety and health that utilize advanced bacterial control-related technologies we have developed over the years. Q: What are polymeric micelle anti-cancer drugs? A: Polymeric micelle anti-cancer drugs are nanoparticles 20 to 100 nm in diameter, in which a low-molecular-weight anti-cancer drug is entirely enclosed and separated from the external environment by string-like large polymers. Each large polymer is constructed with a hydrophilic moiety, polyethylene glycol, at the external end, and a hydrophobic moiety at the internal end. Each “string” has a molecular weight of tens of thousand units, and their aggregation results in weights of millions of units.

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会社案内英語_本文_2020.indd 11 2020/09/16 10:0 ■Principal pharmaceutical fields

“Sukima” of tomorrow: Polymeric micelle anti-cancer drugs

Core: Anti-cancer drug 20 to 100 to nm 20 ●Diagnostic drugs

Sequence in drug-delivery system

Hydrophilic Blood ●Food-related activities vessel Hydrophobic At Nippon Kayaku Food Techno Co., Ltd., our consolidated subsidiary, we are engaged in the manufacture and sales of ethanol preparations, which reduce Anti-cancer drug release food waste by improving the shelf life of food products, and preservatives for food quality, which curb the growth of mold and microbes, cleaning disinfec- Escape from blood vessel tants, which sanitize food manufacturing environments, and raw materials for health food products. We are aiming to contribute to the society with our products and services for food safety and health that utilize advanced bacterial control-related technologies we have developed over the years. Q: What are polymeric micelle anti-cancer drugs? A: Polymeric micelle anti-cancer drugs are nanoparticles 20 to 100 nm in diameter, in which a low-molecular-weight anti-cancer drug is entirely enclosed and separated from the external environment by string-like large polymers. Each large polymer is constructed with a hydrophilic moiety, polyethylene glycol, at the external end, and a hydrophobic moiety at the internal end. Each “string” has a molecular weight of tens of thousand units, and their aggregation results in weights of millions of units.

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会社案内英語_本文_2020.indd 12 2020/09/16 10:0 Safety Systems Business ■Main products

Before collision Airbag (including inflator) Airbag diagnostic ●Airbag inflators device Collision sensor An inflator is a gas generator that inflates the air bag. Nippon Kayaku started with inflators for driver's seat and passenger seat applications, and later expanded our scope to add inflators for side air bags, curtain air bags, and knee air bags to our portfolio. We continue to develop new products, to enhance the safety of vehicles. Seatbelt pretensioner (including micro gas generator)

1 The Collision sensor is a device embedded ●Squibs in the front portion of the vehicle, Supporting Driver’s Safety which detects collisions. A squib is an ignition part embedded in inflators and 2 The Diagnostic device determines whether micro gas generators. When the sensor detects a colli- a collision is caused by an accident or not. Our modern automobile society sometimes has to balance safety with sion, an electric current is sent to the squib, and then the 3 When determined as an accident, an electrical signal is relayed to the squib. other concerns. For example, the amount of traffic is increasing, and heat that is generated ignites the agent inside the squib, leading to its activation. Upon activation, the ignition 4 The squib's explosive agent is ignited automobiles are being made lighter to enhance fuel efficiency. These by the relayed electrical signal. and heat from the squib is transferred to the gas generat- make it all the more important to ensure and improve automobile 5 Gas generating agent is ignited, ing agent of the inflator or micro gas generator which and gas is generated. generates the gas used to propel the device. user’s safety. Our Safety Systems Business helps advance user’s 6 When the "airbag" is inflated, the "seatbelt pretensioner" retracts the seatbelt, absorbing safety and evolution of the automobile society by developing, manu- the shock received by the passenger. facturing and selling airbag inflators and micro gas generators, which *This process from 1 to 6 is completed in about 0.05 seconds. are essential components of airbags and seatbelt pretensioners that support passenger’s safety. ● Micro Gas Generators for seatbelt pretensioner After collision Airbag deploys

A micro gas generator is a device that acts to retract the Electrical signal seatbelt (seatbelt pretensioner) in the event of a collision. Sensor detects is analyzed The retraction of the seatbelt fixes the body to the ideal collision Rediscovering our roots: 1916 position in relation to the inflated airbag. This increases Nippon Kayaku has a long history of developing, the effectiveness of the airbag, maximizing the safety for manufacturing and selling dynamite and electric the passenger. As a safety device during an accident, its detonators since our start as the first Japanese industrial additional usages are being put in place, such as the shift- explosives manufacturer in 1916. We have made full use ing of the headrests or seats, or a system where the front hood is popped up to protect pedestrians. of our technologies and know-how in a unique blending Seatbelt pretensioner retracts of mechanics and chemistry (especially explosives) to seatbelt design, develop and manufacture airbag inflators and other automotive safety devices.

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会社案内英語_本文_2020.indd 1 2020/09/16 10:0 Safety Systems Business ■Main products

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会社案内英語_本文_2020.indd 1 2020/09/16 10:0 Agrochemicals Business ■Agrochemical Business products

●Agricultural chemicals We offer agricultural chemicals that bring together our production technology and know-how and meet the needs of the times.

Insecticide:“FINESAVE”

Since June 2018, we have offered FINESAVE, a new insecticide particularly effective for hard to control crop pests such as thrips.

Insecticide blocking spiracles, antimicrobial, spreading agent:“FUHMON”

We have offered FUHMON as an agrochemical suitable for integrated pest management that does not rely on chemical pesticides alone. Beside insecticidal efficacy, the product functions as an antimicrobial and spreading agent. We have also worked to develop products such as“CHLOPIC FLOW,” an easy Supporting Food and Agriculture to handle product to obtain stable effects, and“WIDE COAT,” a new spreading agent that combines spreading and sticking functions. Without food, there would be no life. The farm is where food is produced. The world’s population is rising rapidly and demand for food is growing ●Insecticides for public health globally. Thus our world needs a safe and stable supply of food we can We offer chemicals to protect from hygiene pests like cockroaches, count on into the future. This requires agrochemicals that are good for the bed bugs and ticks. environment and suited for today’s agricultural patterns, which include Insecticide PROPETAMPHOS CS“ SAFROTIN MC” older farmers and people working side jobs. Using our fine chemicals exper- Safrotin, which has long been used to protect form hygiene pests, now comes in microcapsule form. It has long-lasting effectiveness and is highly safe. It is particularly effective against cock- tise, we develop, manufacture and sell insecticides, fungicides, herbicides, roaches, since the capsules break down the special structure of their digestive tracts. soil fumigants and insecticides for public health, among others. By supplying chemicals that meet the needs of the times, we support people’s lifestyles. ●Other chemicals Animal repellent R-731

This animal repellent contains microcapsules of capsaicin, the sharp-tasting component of chili peppers. Kneaded into cables and other goods, it prevents rats from chewing and harming those goods. Rediscovering our roots: 1934

The roots of our Agrochemicals Business go back to 1934, when we started manufacturing the fumigant chloropicrin. In 1956, we “Sukima” of tomorrow: microcapsule Polymeric Active formed a technical tie-up with the Swiss firm J.R. Geigy Ltd. (now membrane ingredient Syngenta AG) and began domestic production of the insecticide chemical technology diazinon at our Oji Pharmaceutical Plant. It was reported that a line Our microcapsule chemical technology is a first for agri- of trucks formed around the plant to get the product. These two cultural chemicals in Japan. Controlling the capsule size chemicals were the basis for a variety of products designed for and strength and the rate at which chemicals leach out different uses and are still used on farms today. Dozens of nm makes it possible to tailor agents to be epidemic prevention insecticide or animal repellent.

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会社案内英語_本文_2020.indd 15 2020/09/16 10:0 Agrochemicals Business ■Agrochemical Business products

●Agricultural chemicals We offer agricultural chemicals that bring together our production technology and know-how and meet the needs of the times.

Insecticide:“FINESAVE”

Since June 2018, we have offered FINESAVE, a new insecticide particularly effective for hard to control crop pests such as thrips.

Insecticide blocking spiracles, antimicrobial, spreading agent:“FUHMON”

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会社案内英語_本文_2020.indd 16 2020/09/16 10:0 Research and Our Core Technologies Development System

Our vast accumulation of technologies holds There is no “sukima,” our current business. between our research centers.

At Nippon Kayaku's core are technologies of fine chemicals, which we have built up in the Each division of R&D work together as one with the business groups and divisions to strengthen fields of explosives, dyes and pharmaceuticals (all of which derived from our original prod- the vertical threads of our system of product development so that it captures market needs accu- ucts) along with resins (a field we entered later), among others. With these core technolo- rately. As the group in charge of strengthening the horizontal threads of R&D that cross organiza- gies, and new technologies created through their fusions, we have been conceiving new tional boundaries, the Research and Development Group is responsible for overall R&D activities products and businesses. We will continue to strengthen, expand and fuse our core tech- such as integration of intellectual property and management of corporate research. nologies to create new products that meet the needs of the times. We will continue working to create the best products through the fusion of knowledge and technologies based on this strong organization, woven together by these vertical and horizontal threads.

Vertical threads (strengthen the vertical threads) Explosive Pharmaceutical Put each research laboratory under each business group and division Structure in which accurately ascertaining market needs, technologies technologies the business groups and division, the manufacturing divisions, and the R&D divisions will work together as one to implement R&D that is focused on outcomes

Functional Safety Pharmaceuticals Agrochemicals Chemicals Systems Business Business Business groups and division New type Business Business Outside Polymeric micelle gas-generating technologies anti-cancer drugs agent Intellectual Property Division Horizontal threads (clearly delineate the horizontal threads) Creating the best products Strengthen cross-organizational R&D through the fusion of Creation and provision of knowledge and technologies intellectual added value Dye Resin Catalyst R&D Planning Division Advancement of company-wide R&D technologies technologies technologies Center for Innovative by integrating internal and Polarizing films Research external technologies

Optical functional films Research & Development Group Functional Pharmaceuticals Safety Systems UV-curable resin Chemicals Agrochemicals Organic semiconductors Research Development R&D Laboratories Laboratories Laboratories R&D divisions Colorants for inkjet printers Laboratories

Open innovation with external partners

○Explosives technology ○Dyestuff technology ○Functional Chemicals R&D Laboratories ○Pharmaceuticals Research Laboratories

Using technologies learned from years of Our accumulated technology, which has As the research and development depart- The Pharmaceuticals Research Laborato- explosives and detonator manufacturing, changed based on needs of the times, ment of the Functional Chemicals Group, ries specialize in research and develop- we are undertaking the challenge of devel- has evolved to a high level and is now the Functional Chemicals R&D Laboratories ment of anti-cancer drugs as well as in oping new technologies. Based on those used in colorants for inkjet printer inks, are involved in a variety of research and peripheral areas, such as polymeric micelle technologies, we have developed automo- and for the color filters of digital camer- development areas, including resins, colo- anti-cancer drugs using nanotechnology, tive safety devices that require timing con- as and other products. rants, films, catalysts and new materials that biosimilar and development of generic trol at the millisecond level. derive from these. anti-cancer drugs.

○Pharmaceutical technology ○Resin technology ○Safety Systems Development Laboratories ○Agrochemicals Laboratories

By fusing our low-molecular synthesis By combining our Dye technology with The Safety Systems Development Labora- In order to contribute to an abundant technology developed in the pharmaceu- technology built up through the develop- tories develop automotive safety devices and safe food supply we can rely on, the tical field with our high polymer technol- ment of various resins, we have created a such as airbag inflators that instantly Agrochemicals Laboratories conduct ogy established through the development number of new products such as polariz- inflate airbags and micro gas generators R&D on environmentally friendly of resins, we have created new "Polymeric ing films and optical functional films. that create force to retract seatbelts chemical pesticides and new functional micelle anti-cancer drugs," which are automatically. agrochemical preparations. currently undergoing clinical trials.

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会社案内英語_本文_2020.indd 1 2020/09/16 10:0 Research and Our Core Technologies Development System

Our vast accumulation of technologies holds There is no “sukima,” our current business. between our research centers.

Open innovation with external partners

○Explosives technology ○Dyestuff technology ○Functional Chemicals R&D Laboratories ○Pharmaceuticals Research Laboratories

○Pharmaceutical technology ○Resin technology ○Safety Systems Development Laboratories ○Agrochemicals Laboratories

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会社案内英語_本文_2020.indd 18 2020/09/16 10:0 History

Kayaku Supports.

Nippon Kayaku is a chemicals manufacturer with a long history. Founded in 1916 as Japan's first joint-stock corporation manufacturing industrial explosives, it has since launched various technologies and diverse products. The technologies we bring out may change in form, but they continue to support convenience, comfort, confidence and safety for people’s lives. At their root is the ideal of“serving society with products that enhance human happiness.” Moving into the future, Nippon Kayaku continues to embrace this ideal. Capital investment in INTED SAFETY SYSTEMS a.s. (currently Kayaku Safety Systems Europe a.s.) in Czech Republic. 1969 Launched sales of an anti-cancer drug, BLEO™ Acquired MicroChem Corp. (currently KAYAKU Advanced Materials, Inc.) in the USA

Established Kayapola Co., Ltd. 2011 "KAYAKUMA" created Established acrylic acid manufacturing company (sold off in 1983) with Showa Denko Acquired LCD and semiconductor cleaner business of Henkel AG & Co. KGaA 1932 Yamakawa Aspirin Acquired Nippon Kayaku Fukuyama Co., Ltd. and Tokyo Co., Ltd. Received the Deming Prize(given to organizations making advancements in overall quality control). Established Kayaku Safety Systems de Mexico, S.A. C.V. in Mexico 1916 Founded Nippon Kayaku Seizo Co., Ltd. Established Kayaku Safety Systems Malaysia Sdn. Bhd. in ： "KAYAKUMA" the Nippon Kayaku Group’s original mascot created. 1963 Awarded Deming Application Prize for families and caregivers of seriously ill children undergoing treatment.

Polarizing plate technology Kasei Chemicals Corporation to establish Kayaku Japan Co., Ltd. Established Kayaku Safety Systems (Huzhou) Co., Ltd. in China

Ltd. Co., Seiyaku Yamakawa and Ltd. Co., Seizo Senryo Teikoku Acquired industrial explosives manufacturer in Japan Made Polatechno Co.,Ltd a wholly owned subsidiary Merged our industrial explosives business with that of Asahi Technical tie-up with Geigy AG, Switzerland and the production of diazinon,

Established KAYAKU CHEMICAL (WUXI) CO., LTD. in China.

(currently Wuxi Advanced Kayaku Chemical Co., Ltd.), in China. Established Teikoku Senryo Seizo Co., Ltd. Established a joint venture, Wuxi Advanced Chemical Co., Ltd. marketing Aspirin the following year The corporate slogan, adopted. Completed "Asunaro House," an accommodation facility Launched the Research & Development Group. Launched BLEO (anti-cancer drug) Established a subsidiary company in food business, Began as Nippon Kayaku Seizo Co., Ltd., the first Established Yamakawa Seiyaku Co., Ltd. and began Established the Safety Systems Group. Changed company name to Nippon Kayaku Co., Ltd. (Later established POLATECHNO CO., LTD. in 1991) Began selling airbag inflators 100th anniversary of founding an insecticide, started NIPPON KAYAKU FOOD TECHNO CO., LTD. Began selling epoxy resin Completed the training center "Hishou."

Listed on the Tokyo Stock Exchange. ：： MEMS technology .

： Pharmaceutical technology. Explosives technology. ：

： Agrochemical technology. Dyestuff technology ：： entry into cancer field. ： Inflator technology Catalyst technology ： Resin technology 2020 2019 2018 2016 2011 2012 2007 2007 2008 2009 . 2002 2005 2006 2008 1998 1999 1916 1996 1916 1992 1995 1931 1943 1992 1945 1949 1956 1963 1969 1970 1971 1985

19 NIPPON KAYAKU BUSINESS STYLE NIPPON KAYAKU BUSINESS STYLE 20

会社案内英語_本文_2020.indd 19 2020/09/16 10:0 History

Kayaku Supports.

Polarizing plate technology Kasei Chemicals Corporation to establish Kayaku Japan Co., Ltd. Established Kayaku Safety Systems (Huzhou) Co., Ltd. in China

Established KAYAKU CHEMICAL (WUXI) CO., LTD. in China.

Listed on the Tokyo Stock Exchange. ：： MEMS technology .

： Pharmaceutical technology. Explosives technology. ：

19 NIPPON KAYAKU BUSINESS STYLE NIPPON KAYAKU BUSINESS STYLE 20

会社案内英語_本文_2020.indd 20 2020/09/16 10:0 Organization(as of August 1, 2021)

Corporate Planning Division Shareholders Meeting Strategic CSR Dept. Corporate Planning Group Public Relations & Investor Relations Division Secretarial Division

Board of Research & R&D Planning Division Directors Development Group Intellectual Property Division

Planning & Coordination Division

Quality Assurance Division

Functional Materials Division

Color Materials Division Functional President Executive Directors Chemicals Catalysts Division Group Polatechno Division

Management Functional Chemicals R & D Laboratories Meeting Fukuyama Plant / Asa Plant (Above the Managing Directors) Tokyo Plant / Joetsu Plant CSR Management Committee Medical Information Supervision Dept.

Planning & Coordination Division

Ethics Committee Business Development Division Audit ＆ Supervisory Pharmaceuticals Marketing Division Board Medical Aﬀairs Division Risk Management Pharmaceuticals Committee Quality & Pharmacovigilance Division Audit ＆ Group Supervisory Specialty Chemicals, International & IVD Division Board Member Pharmaceuticals Technical Operations Division Disclosure Committee Pharmaceutical Development Division Pharmaceutical Research Laboratories The Nippon Kayaku Group Environment, Safety, Takasaki Plant Quality Assurance Management Committee Strategic Planning Division around the World

Marketing & Sales Division Safety Systems Energy Conservation & Production Division Global Warming Group Prevention Committee Research & Development Division Himeji Plant

Research & Development Agrochemicals Division Management Committee Agrochemicals Laboratories

Kashima Plant

General Aﬀairs & Human Resources Division

Purchasing Division Administration Legal Aﬀairs Division Group Security Export Control Dept.

Regional Administration Division

Financial Finance & Accounting Division Group Information Systems Division

Quality Management Division Corporate Profile Technical Operations Technical Administration & Engineering Division Group Environmental Protection & Safety Division Business Name Nippon Kayaku Co., Ltd.

Internal Control Management Division Representative Atsuhiro Wakumoto, President Foundation June 5, 1916 Audit Division Capital 14,932 million yen Head Oﬃce Address Meiji Yasuda Seimei Building 19th and 20th Floors, 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 100-0005, Japan Web site https：//www.nipponkayaku.co.jp/english/

2021.8 The Netherlands Germany

■Dejima Tech B.V. Korea Czech Republic ■KAYAKU Advanced Materials, Inc. ■Dejima Optical Films B.V. ■■NIPPON KAYAKU AMERICA, INC. ■Euro Nippon Kayaku GmbH

■■Nippon Kayaku Korea Co., Ltd. ■Kayaku Safety Systems Europe a.s. China U.S.A.

■Shanghai KAYAKU International Trading Co., Ltd. ■MOXTEK, Inc. United Kingdom ■Kayaku (Shanghai) Co., Ltd.

■WUXI POLATECHNO OPTICS CO., LTD. Mexico ■ RaySpec Ltd. ■KAYAKU CHEMICAL (WUXI) CO., LTD. ■WUXI ADVANCED KAYAKU CHEMICAL CO., LTD.

Thailand ■Kayaku Safety Systems (Huzhou) Co., Ltd. Taiwan ■Kayaku Safety Systems de Mexico, S.A. de C.V.

Malaysia ■■NIPPON KAYAKU（THAILAND）CO., LTD. From “sukima” to the World and a New Future: Nippon Kayaku production bases ■■Taiwan Nippon Kayaku Co., Ltd. Functional Chemicals Business ■Kayaku Safety Systems Malaysia Sdn. Bhd.

●Sapporo Pharmaceuticals Branch Fukuyama Plant Asa Plant Tokyo Plant Joetsu Plant

Head Office "Hishou" (training center) ●Joetsu Plant

●Research & Development ●Nagoya Pharmaceuticals Branch ■POLATECHNO CO., LTD. ●Sendai Pharmaceuticals Branch Division ■Teikoku Taping System Co., Ltd. ■Cultivecs Inc. Niigata Factory ●Kita-Kanto and Koshinetsu KAYAKU CHEMICAL KAYAKU Advanced Materials, Inc. WUXI ADVANCED KAYAKU Dejima Optical Films B.V. ●Himeji Plant Pharmaceuticals Branch (WUXI) CO., LTD. CHEMICAL CO., LTD. ●Keiji-Hokuriku Pharmaceuticals ●Takasaki Plant Branch ●"Hishou" (training center) ●Fukuyama Plant ■NIPPON KAYAKU FOOD ■Okiura Golf Center ●Osaka Pharmaceuticals Co., Ltd. Branch TECHNO CO., LTD. ■Gunnan Sangyo Co., Ltd. ●Chu-Shikoku ●Kanto Pharmaceuticals Branch Pharmaceuticals Branch ◆Head Office ●Asa Plant ●Functional Chemicals R&D WUXI POLATECHNO OPTICS CO., LTD. MOXTEK, Inc. RaySpec Ltd. Teikoku Taping System Co., Ltd. ●Functional Chemicals Laboratories Pharmaceuticals Business Safety Systems Business R&D Laboratories ●Tokyo Plant (Catalysts) ●Pharmaceutical Research Laboratories ■Kowa Sangyo Co., Ltd. ●Tokyo Pharmaceuticals Branch ■ Head Oﬃce Kayaku Nouryon Corporation, ●Research & Development Group Asa Plant ■Kayaku Japan ■■NIKKA FINE TECHNO CO., LTD. Co., Ltd., Asa Plant ■Tumor Diagnosis Support ●Agrochemicals Co., Ltd. ■Nishiminato Laboratories ■Wako Toshi Kaihatsu Co., Ltd. Takasaki Plant NIPPON KAYAKU FOOD TECHNO Himeji Plant Kayaku Safety Systems Europe a.s. Driving School CO., LTD. Co., Ltd. ●Kashima Plant ■JAPAN HUMAN RESOURCES Agrochemicals Business MEDICAL SCIENCE RESEARCH INSTITUTE CO., LTD. ■Sanko Chemical Industry ■Kayaku Nouryon Corporation Co., Ltd. ■Kayaku Japan Co., Ltd. ●Fukuoka Pharmaceuticals Branch ■Cultivecs Inc.

●Functional Chemicals Business ●Pharmaceuticals Business ●Safety Systems Business ●Agrochemicals Business ●Others □Group companies Kayaku Safety Systems Kayaku Safety Systems de Kayaku Safety Systems Kashima Plant (Huzhou) Co., Ltd. Mexico, S.A. de C.V. Malaysia Sdn. Bhd. ＊as of August, 2021 The Netherlands Germany

■Dejima Tech B.V. Korea Czech Republic ■KAYAKU Advanced Materials, Inc. ■Dejima Optical Films B.V. ■■NIPPON KAYAKU AMERICA, INC. ■Euro Nippon Kayaku GmbH

■■Nippon Kayaku Korea Co., Ltd. ■Kayaku Safety Systems Europe a.s. China U.S.A.

■Shanghai KAYAKU International Trading Co., Ltd. ■MOXTEK, Inc. United Kingdom ■Kayaku (Shanghai) Co., Ltd.

■WUXI POLATECHNO OPTICS CO., LTD. Mexico ■ RaySpec Ltd. ■KAYAKU CHEMICAL (WUXI) CO., LTD. ■WUXI ADVANCED KAYAKU CHEMICAL CO., LTD.

Thailand ■Kayaku Safety Systems (Huzhou) Co., Ltd. Taiwan ■Kayaku Safety Systems de Mexico, S.A. de C.V.

●Sapporo Pharmaceuticals Branch Fukuyama Plant Asa Plant Tokyo Plant Joetsu Plant

Head Office "Hishou" (training center) ●Joetsu Plant

Corporate Planning Division Shareholders Meeting Strategic CSR Dept. Corporate Planning Group Public Relations & Investor Relations Division Secretarial Division

Board of Research & R&D Planning Division Directors Development Group Intellectual Property Division

Planning & Coordination Division

Quality Assurance Division

Functional Materials Division

Color Materials Division Functional President Executive Directors Chemicals Catalysts Division Group Polatechno Division

Planning & Coordination Division

Marketing & Sales Division Safety Systems Energy Conservation & Production Division Global Warming Group Prevention Committee Research & Development Division Himeji Plant

Research & Development Agrochemicals Division Management Committee Agrochemicals Laboratories

Kashima Plant

General Aﬀairs & Human Resources Division

Purchasing Division Administration Legal Aﬀairs Division Group Security Export Control Dept.

Regional Administration Division

Financial Finance & Accounting Division Group Information Systems Division

2021.8 From “Sukima” to the World and the Future

Our technologies, born from

“global‘Sukima’ ideas,” may not always

get a lot of attention.

However, these technologies support today’s

lifestyles and various industries and are laying

a path to the future.

Count on the Nippon Kayaku Group to continue

bringing forth supporting technologies from“sukima”

to contribute to the world and the future.

21 NIPPON KAYAKU BUSINESS STYLE

会社案内英語_本文_2020.indd 21 2020/09/16 10:0 Message from the President

Our technologies, born from

“global‘Sukima’ ideas,” may not always get a lot of attention.

2101 NIPPON KAYAKU BUSINESS STYLE NIPPON KAYAKU BUSINESS STYLE Nippon Kayaku Co., Ltd. Corporate Information

Web site

Nippon Kayaku Co., Ltd.／Meiji Yasuda Seimei Building 19th and 20th Floors, 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 100-0005, Japan Web site: https://www.nipponkayaku.co.jp/english/ 2020.10