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High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions
0023-6837/00/8002-233$03.00/0 LABORATORY INVESTIGATION Vol. 80, No. 2, p. 233, 2000 Copyright © 2000 by The United States and Canadian Academy of Pathology, Inc. Printed in U.S.A. High Frequency of Allelic Loss in Dysplastic Lichenoid Lesions Lewei Zhang, Xing Cheng, Yong-hua Li, Catherine Poh, Tao Zeng, Robert Priddy, John Lovas, Paul Freedman, Tom Daley, and Miriam P. Rosin Faculty of Dentistry (LZ, Y-HL, CP, RP), University of British Columbia, and BC Cancer Research Centre (MPR), Cancer Control Unit, Vancouver, British Columbia, School of Kinesiology (XC, TZ, MPR), Simon Fraser University, Burnaby, British Columbia, Faculty of Dentistry (JL), Dalhousie University, Halifax, Nova Scotia, and Department of Pathology (TD), University of Western Ontario, London, Ontario, Canada; and The New York Hospital Medical Center of Queens (PF), Flushing, New York SUMMARY: Oral lichen planus (OLP) is a common mucosal condition that is considered premalignant by some, whereas others argue that only lichenoid lesions with epithelial dysplasia are at risk of progressing into oral carcinoma. A recent study from this laboratory used microsatellite analysis to evaluate OLP for loss of heterozygosity (LOH) at loci on three chromosomal arms (3p, 9p, and 17p) (Am J Path 1997;Vol151:Page323-Page327). Loss on these arms is a common event in oral epithelial dysplasia and has been associated with risk of progression of oral leukoplakia to cancer. The data showed that, although dysplastic epithelium demonstrated a high frequency of LOH (40% for mild dysplasia), a significantly lower frequency of LOH was noted in OLP (6%), which is even lower than that in hyperplasia (14%). -
Oral Pigmented Lesions from Brazil
Med Oral Patol Oral Cir Bucal. 2021 May 1;26 (3):e284-91. Oral pigmented lesions from Brazil Journal section: Oral Medicine and Pathology doi:10.4317/medoral.24168 Publication Types: Research Oral pigmented lesions: a retrospective analysis from Brazil Danielle Mendes da Silva Albuquerque 1, John Lennon Silva Cunha 2, Ana Luiza Oliveira Corrêa Roza 3, Lady Paola Aristizabal Arboleda 3, Alan Roger Santos-Silva 4, Marcio Ajudarte Lopes 4, Pablo Agustin Vargas 4, Jacks Jorge 4, Oslei Paes de Almeida 4, Aline Corrêa Abrahão 5, Michelle Agostini 5, Mário José Romañach 5, Bruno Augusto Benevenuto de Andrade 5 1 DDS, MSc. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Brazil 2 DDS, MSc student. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), SP, Brazil 3 DDS, PhD student. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), SP, Brazil 4 DDS, PhD. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), SP, Brazil 5 DDS, PhD. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Brazil Correspondence: Department of Oral Diagnosis and Pathology Federal University of Rio de Janeiro School of Dentistry Av. Carlos Chagas Filho 373, Prédio do CCS, Bloco K, 2° andar, Sala 56 Ilha da Cidade Universitária, Rio de Janeiro/RJ. 21.941-902 [email protected] Received: 16/07/2020 Albuquerque DMdS, Cunha JLS, Roza ALOC, Arboleda LPA, Santos- Accepted: 24/08/2020 Silva AR, Lopes MA, et al. Oral pigmented lesions: a retrospective analysis from Brazil. -
Symmetrical Intertriginous and Flexural Exanthema Due to Bortezomib (A Proteasome Inhibitor) Given for Myeloma
Acta Derm Venereol 2016; 96: 995–996 SHORT COMMUNICATION Symmetrical Intertriginous and Flexural Exanthema due to Bortezomib (a Proteasome Inhibitor) Given for Myeloma Nausicaa Malissen1, Jean-Luc Bourrain1, Anca Chiriac2, Aline Montet1, Laure Vincent3, Olivier Dereure1 and Aurélie Du-Thanh1* 1Dermatology Department, 2Pneumology – Allergology Department, Montpellier University Hospital, and 3Clinical Hematology Department, Montpellier University Hospital, 80 avenue Augustin Fliche, FR-34295 Montpellier cedex 5, France. *E-mail: [email protected] Accepted Mar 17, 2016; Epub ahead of print Mar 22, 2016 Bortezomib is a selective proteasome inhibitor currently discovered, high-risk smouldering multiple myeloma. used as standard of care in the treatment of multiple my- He disclosed no other relevant medical background and eloma. Cutaneous side-effects are frequent, as reported in did not receive any other medication, except for the a phase 3 randomized study (1), in which 57% and 70% following regimen, implemented 15 days before occur- of patients experienced a grade 3 or higher skin toxicity rence of the skin eruption and combining subcutaneous with subcutaneous and intravenous administration, re- bortezomib, 1 mg/m2, on days 1, 4, 8 and 11, thalido- spectively. However, these adverse effects are usually mide, 100 mg daily, dexamethasone, 40 mg daily from poorly described in haematological-based reports, and day 1 to day 4, sulfamethoxazole trimethoprim (SMX- range from benign skin eruption to lethal epidermal TMP) and valaciclovir as prophylactic measures. Initial necrolysis (2), thus it is important to provide a more clinical survey revealed a pruritic and symmetrically specific description when they occur. distributed intertriginous, maculopapular exanthema, localized to the axillae, antecubital fossae, groin, neck and buttocks (Fig. -
Amalgam Pigmentation) on the Palatal Mucosa: a Case Report
Open Access Journal of Dentistry & Oral Disorders Case Report Extensive Amalgam Tattoo (Amalgam Pigmentation) on the Palatal Mucosa: A Case Report Fiqhi MK1*, Essaoudi MA2, Khalfi 1L and Khatib KE1 Abstract 1 Department of Plastic, Maxillofacial and Oral Surgery, Introduction: Amalgam tattoo is the most common exogenous oral Mohammed V Military Teaching Hospital, Rabat, pigmentation, caused by traumatic implantation of dental amalgam into soft Morocco tissue. 2Department of Anatomic Pathology, Mohammed V Military Teaching Hospital, Rabat, Morocco Observation: We report a case of large amalgam pigmentation on right hard palate. *Corresponding author: Fiqhi Mohammed Kamal, Department of Plastic, Maxillofacial and Oral Surgery, Discussion: Amalgam tattoo can sometimes be confused with melanotic Mohammed V Military Teaching Hospital, Rabat, lesions, being then biopsied. Once the diagnosis of amalgam tattoos has been Morocco established, the removal of lesions is not necessary, except for esthetic reasons. Received: March 02, 2018; Accepted: April 03, 2018; Keywords: Amalgam tattoo; Oral mucosa; Pigmentation Published: April 10, 2018 Introduction Oral pigmentations may be classified into two major groups on the basis of their clinical appearance: focal and diffuse pigmentations. All pigmented oral cavity lesions should be viewed with suspicion to eliminate a malignant melanoma. This article deals with an extensive amalgam tattoo lesion on palatal mucosa which required a biopsy for a definitive diagnosis. Case Presentation A 56-year-old man with an unremarkable medical history was referred to the department of maxillofacial surgery on suspicion of mucosal melanoma. Clinical examination found a large brown flat macula located on the right hard palate adjacent to a restored tooth 16 with presence of amalgam fillings (Figure 1). -
Pigmented Lesions of the Oral Mucosa
Assistant Professor Dr : Ameena Ryhan Lecture 1 Pigmented Lesions of the Oral Mucosa Endogenous Pigmentation ❒❒ Focal Melanocytic Pigmentation 1. Freckle/Ephelis 2. Oral/Labial Melanotic Macule 3. Oral Melanoacanthoma 4. Melanocytic Nevus 5. Malignant Melanoma ❒❒ Multifocal/Diffuse Pigmentation 1. Physiologic Pigmentation 2. Drug-Induced Melanosis 3. Smoker’s Melanosis 4. Postinflammatory (Inflammatory) Hyperpigmentation 5. Melasma (Chloasma) ❒❒ Melanosis Associated with Systemic or Genetic Disease 1. Hypoadrenocorticism (Adrenal Insufficiency or Addison’s Disease) 2. Cushing’s Syndrome/Cushing’s Disease 3. Hyperthyroidism (Graves’ Disease) 4. Primary Biliary Cirrhosis 5. Vitamin B12 (Cobalamin) Deficiency 6. Peutz–Jeghers Syndrome 7. Café au Lait Pigmentation 8. HIV/AIDS-Associated Melanosis ❒❒ Idiopathic Pigmentation 1. Laugier–Hunziker Pigmentation ❒❒ Treatment of Mucocutaneous Melanosis ❒❒ Depigmentation 1. Vitiligo ❒❒ Hemoglobin and Iron-Associated Pigmentation 1. Ecchymosis 2. Purpura/Petechiae 3. Hemochromatosis Exogenous Pigmentation 1. Amalgam Tattoo 2. Graphite Tattoos 3. Ornamental Tattoos 4. Medicinal Metal-Induced Pigmentation 5. Heavy Metal Pigmentation 6. Drug-Induced Pigmentation 7. Hairy Tongue 1 Assistant Professor Dr : Ameena Ryhan Lecture 1 Healthy oral soft tissues present a typical pink to red hue with slight topographical variations of color. This chromatic range is due to the interaction of a number of tissues that compose the mucosal lining: The presence or absence of keratin on the surface epithelium The quantity, superficial or deep location of blood vessels in the subjacent stroma, The existence of lobules of adipocytes, The absence of melanin pigmentation in the basal cell layer of the epithelium. Although oral and perioral pigmentation may be physiologic in nature, particularly in individuals with dark skin complexion, in the course of disease, the oral mucosa and perioral tissues can assume a variety of discolorations, including brown, blue, gray, and black. -
Symmetrical Drug-Related Intertriginous and Flexural Exanthema Secondary to Topical 5-Fluorouracil
Symmetrical Drug-Related Intertriginous and Flexural Exanthema Secondary to Topical 5-Fluorouracil Roxann Powers, MD; Rachel Gordon, MD; Kenrick Roberts, MD; Rodney Kovach, MD We report the case of a 56-year-old man who fossae and axillae. His dermatologist stopped the developed a distinctive skin eruption after treat- 5-FU and started prednisone, erythromycin, hydro- ing actinic keratoses on the dorsal aspects of cortisone ointment, and fexofenadine hydrochloride. his right and left hands with topical 5-fluorouracil Over the next week, the areas became eroded and the (5-FU). The distribution of his rash was charac- pain worsened. A biopsy was performed. The hydro- teristic of symmetrical drug-related intertriginous cortisone was discontinued and he was referred for a and flexural exanthema (SDRIFE), also known as second opinion. baboon syndrome. Medications at presentation included erythromycin, Cutis. 2012;89:225-228. fexofenadine hydrochloride, acetaminophen-codeine, CUTISprednisone, petrolatum ointment, metformin Case Report hydrochloride, enalapril maleate, ranitidine hydro- A 56-year-old man with a history of diabetes mel- chloride, simvastatin, triamterene/hydrochlorothiazide, litus, hypertension, hyperlipidemia, reflux, squamous aspirin, and omeprazole. He reported no cell carcinoma in situ of his right hand, and actinic known allergies. keratoses of the right Doand left hands presentedNot with a PhysicalCopy examination revealed an overweight painful, burning, pruritic, erythematous, and blister- man who appeared agitated and reported substantial ing rash on his medial thighs, scrotum, penis, antecu- discomfort. He had well-demarcated, violaceous, red bital fossae, axillae, and dorsal hands. The patient had erosions on his medial thighs (Figure 1), scrotum, a successful history of treatment of actinic keratosis and penis; erythematous denuded patches in the on his right hand with topical 5-fluorouracil (5-FU) antecubital fossae (Figure 2) and axillae; and crusty 8 years prior to presentation. -
Gingival Diseases in Children and Adolescents
8932 Indian Journal of Forensic Medicine & Toxicology, October-December 2020, Vol. 14, No. 4 Gingival Diseases in Children and Adolescents Sulagna Pradhan1, Sushant Mohanty2, Sonu Acharya3, Mrinali Shukla1, Sonali Bhuyan1 1Post Graduate Trainee, 2Professor & Head, 3Professor, Department of Paediatric and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751003, Odisha, India Abstract Gingival diseases are prevalent in both children and adolescents. These diseases may or may not be associated with plaques, maybe familial in some cases, or may coexist with systemic illness. However, gingiva and periodontium receive scant attention as the primary dentition does not last for a considerable duration. As gingival diseases result in the marked breakdown of periodontal tissue, and premature tooth loss affecting the nutrition and global development of a child/adolescent, precise identification and management of gingival diseases is of paramount importance. This article comprehensively discusses the nature, spectrum, and management of gingival diseases. Keywords: Gingival diseases; children and adolescents; spectrum, and management. Introduction reddish epithelium with mild keratinization may be misdiagnosed as inflammation. Lesser variability in the Children are more susceptible to several gingival width of the attached gingiva in the primary dentition diseases, paralleling to those observed in adults, though results in fewer mucogingival problems. The interdental vary in numerous aspects. Occasionally, natural variations papilla is broad buccolingual, and narrow mesiodistally. in the gingiva can masquerade as genuine pathology.1 The junctional epithelium associated with the deciduous On the contrary, a manifestation of a life-threatening dentition is thicker than the permanent dentition. underlying condition is misdiagnosed as normal gingiva. -
An Unusual Treatment of Oral Lichenoid Reaction Without Cutaneous Involvement: a Case Report
Z U F J D P T ! ! BALKAN JOURNAL OF STOMATOLOGY M ISSN 1107 - 1141 B JD H MP UP TUPNB An Unusual Treatment of Oral Lichenoid Reaction without Cutaneous Involvement: A Case Report SUMMARY Panagiotis Kafas1, Christos Stavrianos2, Nikolaos Angouridakis3, Kosmas Manafis4 Oral lichenoid reaction is a clinical entity characterized by 1Aristotle University, School of Dentistry microscopic features of hypersensitivity due to foreign body or contact Department of Dentoalveolar Surgery and Radiology, Thessaloniki, Greece reaction. It is usually presented in the cheek mucosa after chronic contact 2Aristotle University, School of Dentistry Department of Endodontology irritation from various materials used in dentistry. Amalgam restoration Thessaloniki, Greece 3 of tooth cavities has been used for many decades. This filling material is Aristotle University, School of Medicine Department of Head and Neck Surgery occasionally suspected for chronic epidermal reactions in the oral cavity. Thessaloniki, Greece 4General Hospital of Kavala This article discusses the reason of choosing an unusual treatment option Department of Pathology, Kavala, Greece without pharmaceutical use that found to be successful. CASE REPORT (CR) Keywords: Oral Lichenoid Reaction, Tooth Extraction, Amalgam Filling Balk J Stom, 2010; 14:37-40 Introduction components of the amalgam filling, but according to the evidence, this technique had many limitations6. Lichenoid reaction in oral cavity is an immunological In our case, a lady was presented in the clinic condition usually associated to delayed hypersensitivity complaining of painless lesion on the buccal mucosa when a metallic tooth restoration appeared to be in lateral to the lower right third molar. A discussion on the chronic contact to the oral mucosal surface1. -
Not Just Luck
EDITORIAL Not Just Luck few months ago, I described a 52-year-old and encourage potential authors and reviewers. At a female patient’s puzzling rash to a colleague: memorable meeting last winter, during a howling snow- a striking symmetrical, bright-red, sharply- storm one dark Thursday night, I met Susan Busch and defined macular erythema of the genital/ Jane Tallent, the 2009Y2010 Lahey Clinic Dermatology inguinal and medial-gluteal areas, and much Nurse Practitioner Fellowship fellows, quintessential ex- less prominently, the axillae and inframmary folds. Sitting amples of individuals who heartily seek out learning op- Aon her desk was an article, just read, describing this un- portunities. We talked animatedly about ways they might usual drug eruption. Coined the Bbaboon syndrome[ be- contribute to the Journal, and I forgot how sweet it would cause of the resemblance to the red buttocks of baboons, it have been to stay home and light a fire in the fireplace. has been renamed the less colorful, less memorable, but less- When an uncanny opportunity presents itself to apply some- unnerving-to-be-diagnosed- thing we have just learned, we can remind ourselves that we with Bsymmetrical drug-related helped create this fortunate situation; we helped create our intertriginous and flexural exan- own luck. A dermatology nurse approached me at the 2009 thema[ (SDRIFE; Hausermann, Dermatology Nurses’ Association summer meeting in Boston, Harr, & Bircher, 2004). reporting that only a day or two after she was introduced to I said it was good luck that Merkel cell carcinoma by the JDNA article by Victoria she had just read this article, and Garcia-Albea (nee Beebe; Beebe, 2009), she heard colleagues a colleague commented, para- discussing a new patient diagnosed with Merkel cell cancer in phrasing Louis Pasteur, BChance their practice. -
Clinical Communications Symmetrical Drug
Clinical Communications Symmetrical drug-related intertriginous and flexural exanthema: A little-known drug allergy Tullia De Risi-Pugliese, Héloïse Barailler, Aurore Hamelin, Emmanuelle Amsler, Hafida Gaouar, Flore Kurihara, Marie Laure Jullie, Eric Dean Merrill, Annick Barbaud, Philippe Moguelet, et al. To cite this version: Tullia De Risi-Pugliese, Héloïse Barailler, Aurore Hamelin, Emmanuelle Amsler, Hafida Gaouar, et al.. Clinical Communications Symmetrical drug-related intertriginous and flexural exanthema: A little- known drug allergy. Journal of Allergy and Clinical Immunology: In Practice, Elsevier, 2020, 8 (9), pp.3185-3189.e4. 10.1016/j.jaip.2020.04.052. hal-02995700 HAL Id: hal-02995700 https://hal.sorbonne-universite.fr/hal-02995700 Submitted on 9 Nov 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Clinical Communications Symmetrical drug-related intertriginous 2-7) large or small skin folds (especially inguinal, gluteal, axillary, and flexural exanthema: A little-known and mammary) (Figure 1, Table I) were observed. Four patients drug allergy had localized skin vesicles or bullae and 1 (no. 16) had mucosal Tullia de Risi-Pugliese, MDa,b, Héloïse Barailler, MDc, involvement. The eruption occurred shortly after drug exposure a a,b (median, 22 hours; mean, 34; range, 0.5-120). -
Diagnosis of Oral Pigmentations and Malignant Transformations
Singapore Dental Journal 35 (2014) 39–46 Available online at www.sciencedirect.com journal homepage: www.elsevier.com/locate/sdj Review Diagnosis of oral pigmentations and malignant transformations n Bassel Tarakjia, , Ayeisha Umaira, Durga Prasada, Mohammed Alsakran Altamimib aDepartment of Oral Maxillofacial sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia bDepartment of Restorative Dental Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia article info abstract Background: Oral pigmentation is a common finding in the mouth. Pigmentation can be Keywords: either normal or abnormal discoloration of oral mucous membrane. The purpose of this Pigmentation review mainly focuses on the main oral pigmented lesions, in order to help the clinicians Melanin establish a better approach towards the patients with pigmented oral lesions and to Oral provide thorough knowledge regarding such lesions for patient reassurance, early defini- Diagnosis tive diagnosis and prompt treatment. Methods: Relevant data concerning oral pigmented lesions, clinical features and the possibility of malignant transformation of such lesions were reviewed thoroughly from pubmed literature published in English. Pigmented lesions affecting the skin were not included in our review. Results: Few pigmented lesions have been identified and their tendency to become malignant has been reported in the literature. The oral lesions showing malignant transformation reported were mostly case series. Unfortunately, due to lack of long-term studies, follow ups and randomized controlled studies in this respect it was difficult to draw a statistical analysis. This information is quite crucial for general dental practitioners to improve their understanding regarding oral lesions and to differentiate between normal and diseased conditions, so that they can master the skill of differential diagnosis, definitive diagnosis and prompt treatment. -
Skin Allergy to Azole Antifungal Agents for Systemic Use: a Review of the Literature
Send Orders for Reprints to [email protected] Recent Patents on Inflammation & Allergy Drug Discovery 2019, 13, 1-14 1 REVIEW ARTICLE Skin Allergy to Azole Antifungal Agents for Systemic Use: A Review of the Literature Gianfranco Calogiuri1,3, Lene H. Garvey2, Eustachio Nettis3, Paolo Romita4, Elisabetta Di Leo5, Riccardo Caruso6, Lavjay Butani7 and Caterina Foti4,* 1Department of Pneumology and Allergy Hospital Sacro Cuore - Gallipoli, Lecce, Italy; 2Allergy Clinic, Department of Dermato-Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; 3Department of Biomedical Sciences and Human Oncology Unit of Internal Medicine "G. Baccelli", "Aldo Moro" University of Bari Medical School, Policlinico, Bari, Italy; 4Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari, Italy; 5Section of Allergy and Clinical Immunology, Unit of Internal Medicine-"F. Miulli" Hospital, Acquaviva delle Fonti, Bari, Italy; 6Clinica Salus - Brindisi, Brindisi, Italy; 7Section of Pediatric Nephrology, Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA, USA Abstract: Background: Antifungal azoles are the first-line agents used to treat topical and, above all, systemic mycosis. The latter could be life-threating infections in immunocompromised patients. Che- motherapeutic antibiotics, including antifungal azoles, may induce hypersensitivity reactions; however, such immunologic adverse reactions have not been defined and carefully investigated. Objective: The study aimed to provide an update on the evaluation and diagnosis of skin allergy to azole antifungal agents. Methods: This is a systematic review performed on PubMed and Google Schoolbarusing using the key terms “allergy, hypersensitivity, anaphylaxis, immediate-type reaction, delayed-type reaction, keto- conazole, fluconazole, posaconazole, voriconazole, itraconazole, triazoles, imidazoles, antifungals, A R T I C L E H I S T O R Y antimycotics”.