Supplementary Material

BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Postgrad Med J

The code used in the analysis is available on the project GitHub page here.

Links to interactive versions of figures are given in each of the figure legends.

Mooney J, et al. Postgrad Med J 2020;0:1–6. doi: 10.1136/postgradmedj-2020-138944 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Postgrad Med J

Figure S1. P values of correlation analyses of prescribing rates versus practice Index of Multiple Deprivation score by individual drug.

Plotted as -log10 of the p value. Red dashed line indicated the Bonferroni-corrected p value threshold (so values above this are statistically significant). Each bubble represents one drug, with the area of the bubble proportional to the number of items dispensed in 2019 in England. Drugs are ordered along the x-axis by their position in the British National Formulary (BNF) and colour-coded by chapter. Drug names, number of items and correlation coefficients are not shown here but can be viewed on the interactive online version.

Figure S3. P values of correlation analyses of prescribing rates versus practice Index of Multiple Deprivation score by drug class.

Plotted as -log10 of the p value. Red dashed line indicated the Bonferroni-corrected p value threshold (so values above this are statistically significant). Each bubble represents one drug class, with the area of the bubble proportional to the number of items dispensed in 2019 in England. Drug classes are ordered along the x-axis by their position in the British National Formulary (BNF) and colour-coded by chapter. Drug class names, number of items and correlation coefficients are not shown here but can be viewed on the interactive online version.

Figure S4. Correlation coefficients of gastrointestinal system drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 1). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S5. Correlation coefficients of cardiovascular system drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 2). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S6. Correlation coefficients of respiratory system drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 3). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S7. Correlation coefficients of central nervous system drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 4). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S8. Correlation coefficients of infection-related drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 5). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S9. Correlation coefficients of endocrine system drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 6). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S10. Correlation coefficients of obstetric, gynaecological and urinary tract drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 7). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S11. Correlation coefficients of malignancy and immunosuppression drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 8). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S12. Correlation coefficients of nutrition and blood drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 9). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S13. Correlation coefficients of musculoskeletal and joint disease drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 10). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S14. Correlation coefficients of eye disease drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 11). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S15. Correlation coefficients of ear, nose and throat disease drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 12). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S16. Correlation coefficients of skin disease drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 13). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Figure S17. Correlation coefficients of skin disease drug classes and their association with Index of Multiple Deprivation score.

Drug classes are given along the x-axis in their order in the British National Formulary (chapter 14). Bubble area is proportional to the number of prescriptions dispensed in primary care in 2019. Statistically significant associations are signified by red bubbles. A positive correlation coefficient reflects a tendency towards greater prescribing in more socioeconomically deprived practices. Some bubbles are annotated. All drug class names, number of items, correlation coefficients and p values can be viewed on the interactive online version. An interactive version for the individual drugs in this chapter is here.

Table S1. The ten individual drugs with prescribing rates most positively correlated with Index of Multiple Deprivation score.

The prescribing rates of these drugs tend to be greater in more socioeconomically deprived practices. Ranking based on partial  values, adjusted for practice age and sex distribution and practice list size. Number of items are aggregated across all included practices in 2019.

Unadjusted Adjusted

Drug Items Prescribed rho () p value partial rho () p value

Tramadol 6,032,952 0.39 < 1 x 10-20 0.59 < 1 x 10-20

Gabapentin 7,253,259 0.37 < 1 x 10-20 0.57 < 1 x 10-20

Hyoscine butylbromide 1,499,716 0.35 < 1 x 10-20 0.55 < 1 x 10-20

Co-codamol 14,844,654 0.39 < 1 x 10-20 0.54 < 1 x 10-20

Mirtazapine 9,580,317 0.37 < 1 x 10-20 0.52 < 1 x 10-20

Alginic acid compound preparations (e.g. gaviscon) 4,021,684 0.34 < 1 x 10-20 0.50 < 1 x 10-20

Paracetamol 17,217,836 0.25 < 1 x 10-20 0.50 < 1 x 10-20

Coal Tar 582,852 0.46 < 1 x 10-20 0.50 < 1 x 10-20

Morphine sulfate 4,994,096 0.18 < 1 x 10-20 0.48 < 1 x 10-20

Thiamine (vitamin B1) 2,928,570 0.47 < 1 x 10-20 0.48 < 1 x 10-20

Table S2. The ten individual drugs with prescribing rates most negatively correlated with Index of Multiple Deprivation score.

The prescribing rates of these drugs tend to be greater in more affluent (less socioeconomically deprived) practices. Ranking based on partial rho values, adjusted for practice age and sex distribution and practice list size. Number of items are aggregated across all included practices in 2019. All combined ethinylestradiol drugs listed are in the section “Combined hormonal contraceptives”).

Unadjusted Adjusted Items Drug rho () p value partial rho () p value Prescribed Adrenaline 377746 -0.52 < 1 x 10-20 -0.48 < 1 x 10-20

Progesterone 185611 -0.42 < 1 x 10-20 -0.38 < 1 x 10-20

Combined ethinylestradiol 30mcg 2882166 -0.41 < 1 x 10-20 -0.31 < 1 x 10-20

Estradiol 2295015 -0.51 < 1 x 10-20 -0.30 < 1 x 10-20

Estradiol with progestogen 1300260 -0.50 < 1 x 10-20 -0.29 < 1 x 10-20

Typhoid vaccine 649291 -0.07 4.6 x 10-9 -0.25 < 1 x 10-20

Combined ethinylestradiol 20mcg 405859 -0.30 < 1 x 10-20 -0.25 < 1 x 10-20

Hepatitis A/typhoid combined vaccine 204607 -0.15 < 1 x 10-20 -0.24 < 1 x 10-20

Diphtheria vaccine 512047 -0.22 < 1 x 10-20 -0.23 < 1 x 10-20

Combined ethinylestradiol 35mcg 300257 -0.30 < 1 x 10-20 -0.22 < 1 x 10-20

Table S3. List of all drugs analysed with correlation coefficients and p values.

Ordered from the most positive adjusted correlation coefficient to the most negative. Original British National Formulary drug names given.

rho () p value rho () p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Tramadol Hydrochloride 0.39 9.03E-250 0.59 <1.00E-300 Gabapentin 0.37 2.70E-221 0.57 <1.00E-300 Hyoscine Butylbromide 0.35 6.34E-197 0.55 <1.00E-300 Co-Codamol (Codeine Phos/Paracetamol) 0.39 4.30E-256 0.54 <1.00E-300 Mirtazapine 0.37 6.30E-226 0.52 <1.00E-300 Alginic Acid Compound Preparations 0.34 1.25E-186 0.50 <1.00E-300 Paracetamol 0.25 1.46E-96 0.50 <1.00E-300 Coal Tar 0.46 <1.00E-300 0.50 <1.00E-300 Morphine Sulfate 0.18 9.45E-52 0.48 <1.00E-300 Thiamine Hydrochloride 0.47 <1.00E-300 0.48 <1.00E-300 Pregabalin 0.29 2.33E-134 0.48 <1.00E-300 Carbocisteine 0.30 1.32E-138 0.47 <1.00E-300 Amitriptyline Hydrochloride 0.22 2.20E-77 0.47 <1.00E-300 Isosorbide Mononitrate 0.26 7.80E-108 0.46 <1.00E-300 Metformin Hydrochloride 0.45 <1.00E-300 0.44 <1.00E-300 Mebeverine Hydrochloride 0.20 1.02E-60 0.44 <1.00E-300 Theophylline 0.37 1.73E-204 0.44 1.99E-298 Permethrin 0.48 <1.00E-300 0.43 1.27E-304 Glucose Blood Testing Reagents 0.34 2.00E-183 0.43 4.85E-305 Chlorphenamine Maleate 0.43 <1.00E-300 0.42 2.58E-298 Cyclizine Hydrochloride 0.26 1.19E-103 0.42 3.98E-297 Procyclidine Hydrochloride 0.48 <1.00E-300 0.42 3.82E-284 Betahistine Hydrochloride 0.23 3.88E-81 0.42 6.71E-294 Nicorandil 0.25 2.22E-98 0.42 3.82E-286 Lansoprazole 0.24 1.34E-88 0.41 1.11E-280 Hypromellose 0.28 2.93E-127 0.41 1.28E-279 Loperamide Hydrochloride 0.07 3.06E-09 0.41 7.92E-275 Olanzapine 0.43 9.61E-307 0.41 1.47E-272 Carbamazepine 0.24 7.55E-91 0.41 2.37E-272 Sodium Valproate 0.34 3.37E-188 0.41 1.50E-270 Propranolol Hydrochloride 0.20 1.52E-60 0.40 1.64E-268 Tiotropium 0.23 6.61E-81 0.40 9.53E-262 Sertraline Hydrochloride 0.20 3.50E-60 0.40 8.68E-262 Quetiapine 0.35 1.68E-194 0.40 2.94E-257 Dihydrocodeine Tartrate 0.24 6.02E-86 0.40 2.89E-253 Lactulose 0.25 2.00E-98 0.39 8.41E-248 Fluoxetine Hydrochloride 0.14 7.33E-30 0.38 1.72E-236 Enteral Nutrition 0.25 1.75E-101 0.38 1.75E-234

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Ibuprofen 0.26 1.12E-206 0.37 <1.00E-300 Calcipotriol 0.25 6.28E-95 0.37 2.98E-219 Clopidogrel 0.06 6.61E-07 0.37 4.90E-218 Orlistat 0.41 5.58E-264 0.36 6.29E-208 Furosemide 0.05 5.80E-06 0.36 3.28E-214 Montelukast 0.22 1.22E-74 0.36 1.74E-209 Other Emollient Preps 0.35 2.58E-195 0.36 8.97E-207 Pizotifen Malate 0.21 2.27E-69 0.36 6.53E-199 Ivabradine 0.30 2.15E-134 0.35 5.41E-192 Atorvastatin 0.19 7.17E-56 0.35 6.23E-202 Prochlorperazine Maleate 0.18 5.41E-51 0.35 7.57E-200 Topiramate 0.20 1.06E-63 0.35 1.41E-196 Other Multivitamin Preps 0.39 1.60E-247 0.35 1.03E-192 Oxycodone Hydrochloride 0.14 4.13E-29 0.35 2.31E-190 Clotrimazole 0.28 8.96E-254 0.34 <1.00E-300 Biphasic Insulin Aspart 0.30 2.73E-145 0.34 1.26E-181 Simvastatin 0.08 8.26E-11 0.34 3.78E-183 Oxybutynin 0.20 1.66E-61 0.33 2.02E-178 Levetiracetam 0.25 8.70E-101 0.33 1.79E-172 Analgesics with Anti-Emetics 0.36 1.03E-187 0.33 5.97E-157 Quinine Sulfate 0.15 1.11E-37 0.33 2.88E-170 Oral Rehydration Salts 0.43 0.00E+00 0.32 5.11E-166 Peppermint Oil 0.18 4.71E-49 0.32 1.51E-164 Naproxen 0.16 3.54E-39 0.32 7.72E-167 Chlorpromazine Hydrochloride 0.36 1.75E-159 0.32 4.03E-126 Doxycycline Hyclate 0.08 2.71E-13 0.32 7.36E-175 Salbutamol 0.27 1.73E-144 0.32 5.88E-209 Cinnarizine 0.13 6.64E-26 0.32 8.83E-154 Ferrous Sulfate 0.22 1.89E-73 0.32 4.54E-161 Haloperidol 0.26 5.89E-96 0.32 5.83E-148 Lamotrigine 0.15 9.54E-37 0.32 1.41E-158 Fentanyl 0.10 1.51E-15 0.31 1.92E-153 Aluminium Chloride 0.33 2.73E-155 0.31 8.85E-139 Sodium Feredate 0.43 2.97E-296 0.31 3.81E-149 Alverine Citrate 0.22 1.02E-61 0.31 2.38E-125 Bisacodyl 0.31 1.83E-156 0.31 1.26E-152 Cetirizine Hydrochloride 0.24 2.88E-94 0.31 3.44E-154 Folic Acid 0.15 1.76E-34 0.31 3.09E-150 Senna 0.25 1.01E-97 0.31 5.63E-150 Sildenafil (Erectile Dysfunction) 0.10 3.22E-16 0.30 4.19E-148 Atenolol -0.01 3.29E-01 0.30 6.84E-145 Light Liquid Paraffin 0.35 2.67E-191 0.30 1.68E-141

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Capsaicin 0.22 7.54E-75 0.30 7.55E-134 Venlafaxine 0.08 3.77E-10 0.29 1.37E-137 Bisoprolol Fumarate -0.02 8.41E-02 0.29 2.56E-136 Carbomer 940/980 0.10 8.63E-16 0.29 1.72E-134 Ranolazine 0.25 2.74E-92 0.29 1.20E-119 Aripiprazole 0.32 7.15E-181 0.29 5.02E-143 Umeclidinium Brom/Vilanterol 0.16 1.49E-37 0.28 8.74E-112 Calamine 0.46 1.96E-266 0.28 1.88E-95 Ranitidine Hydrochloride 0.09 3.58E-13 0.28 1.00E-125 Baclofen 0.12 6.49E-23 0.28 3.03E-124 Ramipril 0.09 2.71E-13 0.28 3.04E-125 Terbutaline Sulphate 0.13 2.91E-27 0.28 5.02E-122 Amoxicillin 0.24 2.00E-89 0.28 9.39E-125 Zinc Oxide 0.28 1.99E-230 0.28 1.37E-231 Solifenacin 0.13 9.06E-26 0.27 1.42E-119 Insulin Glargine 0.21 9.56E-68 0.27 1.70E-119 Paroxetine Hydrochloride 0.09 3.27E-14 0.27 1.05E-118 Mebendazole 0.36 7.82E-212 0.27 3.18E-116 Trazodone Hydrochloride 0.16 1.85E-37 0.27 9.36E-109 Ticagrelor 0.22 1.02E-73 0.27 3.97E-113 Prednisolone Acetate 0.21 3.77E-54 0.27 1.40E-85 Macrogol 3350 -0.07 3.41E-09 0.27 5.88E-115 Liraglutide 0.21 8.88E-68 0.27 8.53E-111 Ketone Blood Testing Reagents 0.19 3.34E-56 0.27 1.78E-111 Citalopram Hydrobromide 0.00 7.95E-01 0.27 1.15E-111 Nitrazepam 0.18 1.94E-45 0.27 1.15E-96 Biphasic Insulin Lispro 0.29 1.47E-122 0.26 7.47E-98 Clobazam 0.23 2.04E-80 0.26 6.24E-101 Acamprosate Calcium 0.27 1.27E-79 0.26 1.28E-72 Bendroflumethiazide -0.04 2.65E-04 0.26 2.11E-105 Amisulpride 0.32 3.27E-136 0.26 5.52E-89 Fluticasone Propionate (Inh) 0.06 7.00E-08 0.26 3.16E-104 Diazepam 0.06 1.16E-07 0.25 4.17E-102 Promethazine Hydrochloride 0.28 1.06E-121 0.25 3.07E-98 Risperidone 0.24 3.69E-104 0.25 2.03E-110 Chlorhexidine Gluconate 0.26 1.31E-202 0.25 5.50E-188 Pancreatin 0.08 2.31E-11 0.25 3.24E-95 Nefopam Hydrochloride 0.23 1.39E-55 0.25 2.77E-65 Promazine Hydrochloride 0.33 5.48E-57 0.25 1.07E-31 Diethylamine Salicylate 0.29 9.71E-96 0.24 2.36E-69 Metoclopramide Hydrochloride 0.05 7.01E-06 0.24 7.83E-94 Naftidrofuryl Oxalate 0.25 4.82E-61 0.24 2.13E-57

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Miconazole 0.18 9.91E-51 0.24 1.09E-88 Colecalciferol 0.09 1.43E-13 0.24 7.78E-91 Gliclazide 0.26 2.97E-108 0.24 1.46E-89 Hydroxyzine Hydrochloride 0.20 2.42E-59 0.24 1.09E-86 Alfacalcidol 0.23 1.12E-85 0.24 2.52E-88 Flucloxacillin Sodium 0.01 4.32E-01 0.24 7.64E-89 Doxazosin Mesilate 0.13 2.99E-27 0.24 1.29E-88 Loratadine 0.11 6.10E-19 0.24 6.53E-88 Amlodipine 0.09 7.24E-13 0.24 1.17E-87 Benzydamine Hydrochloride 0.26 2.41E-138 0.23 1.12E-108 Vitamins Caps 0.30 4.82E-113 0.23 3.63E-69 Other Barrier Preps 0.26 3.76E-81 0.23 3.48E-67 Buspirone Hydrochloride 0.24 8.30E-56 0.23 3.46E-53 Phenytoin Sodium 0.09 4.27E-14 0.23 1.82E-78 Biphasic Isophane Insulin 0.18 1.04E-47 0.23 9.76E-79 Emollient Bath & Shower Preparations 0.16 4.92E-43 0.23 6.84E-81 Hydroxocobalamin -0.04 1.41E-03 0.22 1.46E-79 Pioglitazone Hydrochloride 0.22 2.68E-70 0.22 4.15E-74 Betamethasone Valerate 0.07 4.21E-08 0.22 2.21E-78 Azithromycin 0.11 3.78E-21 0.22 3.35E-84 Simple 0.37 6.10E-173 0.22 3.40E-60 Sulfasalazine -0.02 5.63E-02 0.22 2.44E-77 Urea 0.16 1.54E-39 0.22 3.74E-77 Nystatin 0.15 1.99E-40 0.22 1.33E-90 Verapamil Hydrochloride 0.00 9.27E-01 0.22 5.88E-74 Nifedipine 0.08 1.67E-11 0.22 8.41E-76 Linagliptin 0.22 5.48E-78 0.22 2.94E-74 Zonisamide 0.21 8.64E-47 0.22 2.40E-49 Other Food For Special Diet Preps 0.13 1.57E-28 0.22 7.55E-74 Selenium Sulfide 0.35 2.62E-134 0.22 3.46E-51 Co-Dydramol (Dihydrocodeine/Paracet) 0.19 3.04E-59 0.22 2.57E-72 Spironolactone 0.01 6.75E-01 0.22 7.52E-73 Glimepiride 0.25 7.09E-80 0.21 3.81E-58 Co-Magaldrox 0.29 8.99E-67 0.21 6.48E-36 Buprenorphine 0.01 3.49E-01 0.21 1.29E-71 Calcium Acetate 0.29 8.70E-86 0.21 5.74E-45 Valproic Acid 0.23 4.97E-90 0.21 7.25E-79 Clonidine Hydrochloride 0.19 5.31E-77 0.21 1.22E-95 Tranexamic Acid 0.23 7.30E-83 0.21 1.88E-66 Allopurinol -0.10 4.58E-17 0.20 3.54E-66 Rifaximin 0.24 7.61E-51 0.20 6.08E-38 Methocarbamol 0.19 6.62E-32 0.20 1.13E-36

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Carbimazole 0.14 9.08E-32 0.20 6.38E-65 Canagliflozin 0.24 1.43E-75 0.20 3.39E-54 Glycopyrronium Bromide 0.19 3.84E-73 0.20 4.70E-81 Ondansetron Hydrochloride 0.08 1.04E-11 0.20 3.36E-61 Acetic Acid 0.16 2.14E-32 0.20 3.15E-49 Ursodeoxycholic Acid 0.05 1.71E-05 0.20 2.75E-58 Acetazolamide 0.19 2.64E-48 0.20 8.65E-51 Trospium Chloride 0.17 4.20E-39 0.20 1.02E-51 Lorazepam 0.00 7.15E-01 0.20 7.97E-61 Hyoscine 0.15 2.81E-30 0.20 4.08E-53 Dosulepin Hydrochloride 0.05 7.75E-05 0.20 7.58E-56 Sulpiride 0.25 1.91E-60 0.20 2.38E-37 Pramipexole -0.01 5.63E-01 0.20 6.27E-53 Heparinoid 0.18 1.64E-85 0.19 1.77E-101 Insulin Aspart 0.06 4.10E-06 0.19 9.57E-58 Pholcodine 0.27 8.29E-81 0.19 9.57E-40 Eplerenone 0.08 3.95E-12 0.19 4.96E-55 Varenicline Tartrate 0.13 1.50E-24 0.19 1.79E-50 Ferrous Fumarate 0.22 8.35E-76 0.19 5.73E-56 Ipratropium Bromide 0.11 1.49E-32 0.19 4.89E-95 Zopiclone 0.03 6.75E-03 0.19 1.31E-54 Primidone 0.11 6.49E-17 0.18 1.98E-41 Trimethoprim -0.11 1.21E-18 0.18 1.20E-53 Salmeterol 0.02 1.01E-01 0.18 1.05E-48 Lofepramine Hydrochloride 0.13 1.26E-21 0.18 1.38E-38 Moxonidine 0.12 2.31E-19 0.18 1.04E-44 Other Camouflage Preps 0.28 3.53E-80 0.18 3.25E-34 Celecoxib 0.04 5.79E-03 0.18 2.29E-45 Methyl Salicylate 0.33 5.31E-75 0.18 6.22E-23 Other Sunscreening Preps 0.18 3.37E-41 0.18 1.13E-42 Darifenacin Hydrobromide 0.15 2.50E-16 0.18 2.23E-22 Salicylic Acid 0.32 1.07E-194 0.18 8.95E-61 Warfarin Sodium -0.15 6.11E-38 0.18 3.25E-50 Crotamiton 0.11 2.58E-19 0.18 4.55E-45 Omeprazole -0.06 1.15E-06 0.18 1.95E-50 Nortriptyline 0.06 7.41E-07 0.18 2.44E-48 Exenatide 0.15 6.40E-26 0.18 3.49E-34 Propantheline Bromide 0.17 2.49E-30 0.18 2.15E-33 Phenoxymethylpenicillin (Penicillin V) 0.11 9.81E-20 0.18 6.66E-49 Duloxetine Hydrochloride 0.10 1.21E-31 0.18 3.37E-92 Tars 0.16 2.11E-32 0.17 7.96E-40

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Ezetimibe 0.01 2.27E-01 0.17 9.74E-48 Prasugrel 0.17 4.21E-24 0.17 8.81E-26 Fenofibrate 0.13 2.02E-27 0.17 3.11E-45 Temazepam 0.02 6.60E-02 0.17 1.17E-44 Pseudoephedrine Hydrochloride 0.26 6.99E-59 0.17 4.41E-27 Desmopressin Acetate 0.03 2.05E-02 0.17 2.19E-44 Silver Sulfadiazine 0.16 9.41E-31 0.17 1.96E-34 Sodium Picosulfate 0.19 1.12E-70 0.17 2.49E-57 Alogliptin 0.11 1.63E-16 0.17 1.48E-35 Disulfiram 0.21 1.27E-22 0.17 1.50E-14 Aclidinium Bromide 0.12 1.17E-18 0.17 1.11E-34 Balsalazide Sodium 0.15 3.83E-17 0.17 2.39E-21 Carvedilol 0.04 7.53E-04 0.17 4.13E-43 Calcium Carbonate 0.14 1.57E-35 0.17 7.30E-51 Esomeprazole -0.05 1.44E-04 0.17 8.95E-44 Linaclotide 0.18 6.23E-30 0.17 3.93E-25 Dipyridamole 0.09 2.92E-13 0.17 8.38E-38 Degarelix 0.15 4.47E-08 0.17 1.36E-09 Tolterodine -0.03 1.50E-02 0.16 7.62E-43 Empagliflozin 0.17 1.36E-44 0.16 3.59E-42 Oxazepam 0.15 4.08E-16 0.16 3.45E-19 Diamorphine Hydrochloride (Systemic) -0.02 3.20E-01 0.16 1.61E-17 Tiotropium Brom/Olodaterol 0.08 5.88E-09 0.16 3.73E-33 Insulin Degludec 0.08 5.13E-10 0.16 6.18E-40 Quinine Bisulfate 0.12 2.62E-19 0.16 6.83E-36 Reboxetine 0.17 2.06E-13 0.16 6.19E-12 Clonazepam 0.05 7.98E-05 0.16 1.30E-41 Phenobarbital 0.07 1.97E-07 0.16 4.40E-33 Urine Testing Reagents 0.15 3.84E-29 0.16 3.77E-35 Fesoterodine Fumarate 0.14 4.87E-26 0.16 7.86E-32 Aminophylline Hydrate 0.19 2.28E-46 0.16 8.70E-34 Zuclopenthixol Hydrochloride 0.21 1.03E-29 0.16 3.73E-18 Cilostazol 0.22 4.36E-17 0.16 7.70E-10 Cocois 0.13 1.10E-25 0.16 5.83E-38 Nabumetone 0.17 2.70E-12 0.16 2.25E-11 Flavoxate Hydrochloride 0.17 3.77E-10 0.16 3.81E-09 Digoxin -0.18 2.66E-49 0.16 1.88E-40 Trihexyphenidyl Hydrochloride 0.21 5.24E-47 0.16 1.20E-27 Dapagliflozin 0.16 7.29E-38 0.16 5.14E-39 Domperidone 0.07 4.83E-09 0.16 3.61E-39 Indacaterol Maleate 0.21 1.37E-17 0.16 3.09E-10 Medicated Stockings 0.13 3.78E-10 0.16 3.92E-14

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Loprazolam Mesilate 0.18 1.52E-14 0.16 6.85E-11 Zuclopenthixol Decanoate 0.16 2.45E-13 0.16 9.48E-13 Gluten Free Bread 0.05 6.18E-04 0.16 3.43E-26 Irbesartan 0.15 4.75E-37 0.15 5.49E-38 Hyoscine Hydrobromide 0.20 7.45E-40 0.15 4.23E-24 Sitagliptin 0.23 1.53E-85 0.15 8.17E-38 Dulaglutide 0.14 7.60E-28 0.15 2.89E-34 Hydrocortisone Butyrate 0.14 7.40E-22 0.15 1.07E-25 Ropinirole Hydrochloride -0.08 2.29E-09 0.15 2.64E-34 Co-Trimoxazole 0.08 7.66E-11 0.15 3.45E-34 Dimeticone (Parasiticidal) 0.31 1.45E-59 0.15 2.85E-15 Aclidinium Brom/Formoterol 0.13 2.34E-20 0.15 4.47E-26 Levomepromazine Maleate 0.17 7.52E-24 0.15 6.51E-19 Nebivolol 0.06 6.67E-07 0.15 3.33E-34 Isophane Insulin 0.09 1.52E-14 0.15 2.31E-35 Sodium Citrate (Rectal) 0.00 9.52E-01 0.15 1.30E-31 Menthol 0.05 1.31E-04 0.15 7.70E-34 Rabeprazole Sodium -0.03 1.02E-02 0.15 1.91E-29 Beclometasone Dipropionate 0.09 5.52E-25 0.15 3.23E-73 Midazolam Hydrochloride 0.14 2.69E-27 0.15 1.73E-31 Malathion 0.31 8.66E-76 0.15 3.43E-18 Sodium Bicarbonate 0.18 7.65E-56 0.15 1.16E-39 Dexpanthenol 0.24 3.21E-34 0.15 2.37E-13 Benzoyl Peroxide 0.09 2.24E-13 0.15 1.55E-32 Methyldopa 0.13 3.35E-17 0.15 3.93E-20 Labetalol Hydrochloride 0.22 1.45E-68 0.15 4.99E-30 Zinc Sulfate Monohydrate 0.17 8.29E-20 0.14 9.49E-15 Mirabegron -0.05 1.10E-04 0.14 9.62E-33 Pravastatin Sodium -0.10 3.31E-16 0.14 1.08E-32 Ispaghula Husk -0.16 1.31E-41 0.14 1.79E-32 Chloral Hydrate 0.24 2.45E-17 0.14 9.24E-07 Docusate Sodium 0.07 8.08E-11 0.14 1.70E-37 Other Food Preps 0.14 1.46E-29 0.14 1.13E-27 Febuxostat 0.03 4.37E-02 0.14 1.50E-25 Captopril 0.14 5.29E-20 0.14 2.74E-18 Phosphates (Rectal) 0.08 1.80E-10 0.14 2.63E-25 Pyridostigmine Bromide 0.11 6.14E-15 0.14 2.68E-21 Insulin Glulisine 0.11 2.64E-14 0.14 1.48E-19 Dantrolene Sodium 0.17 1.31E-15 0.14 1.52E-10 Sodium Cromoglicate 0.21 7.09E-99 0.14 1.20E-40 Metoprolol Tartrate 0.09 2.78E-13 0.14 1.50E-28

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Enoxaparin 0.06 1.26E-06 0.14 8.21E-25 Lercanidipine Hydrochloride -0.03 8.13E-03 0.14 1.09E-28 Levothyroxine Sodium -0.16 5.40E-39 0.14 2.02E-29 Nadolol 0.16 1.14E-09 0.13 5.90E-07 Glyceryl Trinitrate 0.09 5.08E-28 0.13 5.29E-55 Cyproterone Acetate 0.11 7.61E-11 0.13 1.28E-14 Clomipramine Hydrochloride 0.05 4.86E-04 0.13 2.09E-23 Eflornithine Monohydrate Chloride 0.15 7.55E-21 0.13 2.50E-17 Wool Alcohols 0.29 5.68E-36 0.13 1.48E-08 Etodolac 0.10 6.87E-09 0.13 5.70E-14 Flupentixol Hydrochloride 0.16 1.29E-31 0.13 8.24E-23 Alendronic Acid -0.17 1.46E-47 0.13 1.21E-27 Aspirin 0.09 1.23E-21 0.13 2.68E-48 Imipramine Hydrochloride 0.08 2.18E-08 0.13 5.57E-20 Magnesium Aspartate 0.12 8.83E-15 0.13 2.48E-17 Naloxegol 0.16 2.89E-15 0.13 2.83E-10 Xylometazoline Hydrochloride 0.20 3.78E-44 0.13 1.66E-19 Avanafil 0.18 1.58E-12 0.13 6.75E-07 Tapentadol Hydrochloride 0.14 5.16E-19 0.13 7.50E-17 Melatonin 0.03 2.55E-02 0.13 4.82E-25 Mizolastine 0.14 1.89E-11 0.12 1.39E-09 Alimemazine Tartrate 0.16 9.22E-15 0.12 7.20E-10 Choline Salicylate 0.31 2.93E-91 0.12 5.32E-15 Sumatriptan Succinate -0.15 1.73E-34 0.12 6.73E-25 Pantoprazole -0.01 4.15E-01 0.12 1.76E-24 Oseltamivir Phosphate 0.15 9.30E-23 0.12 4.07E-15 Tacalcitol 0.20 1.38E-13 0.12 9.94E-06 Simeticone 0.24 1.52E-52 0.12 3.18E-14 Sodium Chloride 0.11 3.58E-49 0.12 3.46E-61 Dronedarone Hydrochloride 0.10 4.16E-05 0.12 1.71E-06 Piroxicam 0.16 6.97E-43 0.12 1.10E-26 Mebeverine HCl Compound Preparations 0.05 2.00E-04 0.12 1.22E-16 Alfuzosin Hydrochloride -0.01 3.22E-01 0.12 8.94E-23 Nicardipine Hydrochloride 0.17 3.53E-10 0.12 8.36E-06 Nedocromil Sodium 0.24 1.62E-51 0.12 8.62E-14 Diphenhydramine Hydrochloride 0.21 1.69E-23 0.12 1.75E-08 Aluminium & Magnesium & Act Simeticone 0.17 7.90E-16 0.12 2.79E-08 Neomycin Sulfate 0.07 3.03E-08 0.12 2.30E-24 Mefenamic Acid 0.19 1.45E-57 0.12 3.92E-23 Lithium Carbonate 0.01 4.55E-01 0.12 2.50E-22 Chloramphenicol 0.09 1.21E-15 0.12 1.10E-25 Naltrexone Hydrochloride 0.15 9.60E-08 0.12 2.53E-05

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Nicotine 0.16 1.74E-35 0.12 1.59E-21 Perindopril Erbumine -0.02 4.01E-02 0.12 4.84E-23 Sucralfate 0.15 7.72E-11 0.12 2.90E-07 Lacosamide 0.14 3.25E-21 0.12 1.43E-16 Levomepromazine Hydrochloride -0.06 3.37E-05 0.12 6.21E-18 Maltodextrin 0.22 5.32E-17 0.12 1.08E-05 Amiloride Hydrochloride 0.06 5.08E-05 0.12 8.32E-18 Liquid Paraffin 0.20 5.61E-101 0.12 4.21E-37 Water for Injection -0.17 1.27E-42 0.12 3.45E-21 Perampanel 0.17 2.72E-18 0.12 1.19E-09 Tinzaparin Sodium 0.13 2.87E-13 0.12 6.25E-11 Clobetasol Propionate -0.01 6.07E-01 0.12 5.48E-22 Citalopram Hydrochloride 0.07 4.12E-06 0.12 2.31E-14 Erythromycin Ethylsuccinate 0.17 1.33E-42 0.11 4.65E-21 Pethidine Hydrochloride 0.13 3.68E-06 0.11 4.86E-05 Oxycodone HCl/Naloxone HCl 0.14 6.71E-11 0.11 4.93E-08 Fludrocortisone Acetate -0.06 1.26E-07 0.11 1.48E-20 Indapamide -0.02 8.38E-02 0.11 2.95E-21 Codeine Phosphate 0.06 1.38E-10 0.11 2.68E-38 Methylprednisolone Acetate -0.01 4.52E-01 0.11 1.64E-17 Fluvoxamine Maleate 0.15 7.30E-10 0.11 2.72E-06 Propiverine Hydrochloride 0.13 9.91E-09 0.11 2.78E-07 Cyclopentolate Hydrochloride 0.15 3.86E-17 0.11 7.09E-11 Zinc Sulfate 0.18 9.26E-09 0.11 3.25E-04 Ketoprofen 0.12 2.71E-21 0.11 1.18E-17 Paraffin Soft White 0.30 7.24E-57 0.11 1.12E-08 Cefalexin -0.07 5.57E-09 0.11 1.60E-20 Metolazone 0.19 2.42E-19 0.11 1.16E-07 Latanoprost -0.19 5.90E-60 0.11 3.37E-20 Carbomer 974P 0.14 2.46E-15 0.11 1.38E-09 Tadalafil -0.02 1.45E-01 0.11 1.00E-19 Glucagon 0.01 2.82E-01 0.11 2.27E-18 Pentoxifylline 0.17 7.95E-12 0.11 9.08E-06 Medroxyprogesterone Acetate 0.07 4.44E-16 0.11 6.48E-40 Soluble Insulin (Neutral Insulin) 0.09 3.17E-08 0.11 8.41E-11 Benzalkonium Chloride 0.15 5.81E-35 0.11 1.15E-19 Tetrabenazine 0.16 7.08E-13 0.11 2.03E-06 Glucose 0.06 1.52E-09 0.11 2.63E-30 Lidocaine 0.16 5.77E-23 0.11 8.83E-12 Colesevelam Hydrochloride 0.07 2.71E-07 0.11 1.31E-15 Atropine Sulfate 0.12 7.96E-16 0.11 1.38E-13 Promethazine Teoclate 0.17 8.32E-21 0.11 3.59E-09

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Methadone Hydrochloride 0.20 6.59E-31 0.11 8.13E-10 Co-Amilofruse (Amiloride HCl/Frusemide) 0.01 2.73E-01 0.11 2.22E-16 Dicycloverine Hydrochloride 0.11 8.22E-09 0.11 1.27E-08 Ketoconazole 0.12 1.97E-43 0.11 2.48E-34 Felodipine -0.12 3.50E-24 0.11 1.10E-18 Atomoxetine Hydrochloride 0.11 7.32E-15 0.11 4.04E-13 Apixaban -0.16 5.94E-42 0.11 1.01E-18 Bowel Cleansing Solutions 0.19 3.46E-14 0.11 2.66E-05 Flupentixol Decanoate 0.14 6.04E-14 0.11 1.11E-08 Other Phosphate Supplement Preps 0.16 4.47E-19 0.10 1.20E-08 Buprenorphine Hydrochloride 0.23 6.73E-28 0.10 9.92E-07 Diltiazem Hydrochloride 0.05 3.58E-07 0.10 9.61E-29 Colistimethate Sodium 0.10 4.14E-09 0.10 8.26E-09 Etonogestrel 0.10 1.32E-10 0.10 1.12E-10 Fluocinolone Acetonide 0.11 6.39E-17 0.10 4.96E-16 Clobetasone Butyrate 0.04 1.98E-03 0.10 2.68E-17 Insulin Lispro 0.02 8.86E-02 0.10 6.67E-17 Benzocaine 0.26 1.13E-25 0.10 6.84E-05 Saxagliptin 0.15 4.28E-21 0.10 1.04E-10 Vitamin B Compound 0.16 1.23E-39 0.10 1.04E-16 Pyridoxine Hydrochloride 0.15 8.40E-27 0.10 2.55E-12 Amorolfine Hydrochloride 0.13 8.40E-25 0.10 8.17E-16 Diflucortolone Valerate 0.13 1.56E-11 0.10 1.16E-07 Sevelamer 0.22 8.61E-45 0.10 1.83E-10 Cyanocobalamin 0.09 2.10E-14 0.10 1.06E-15 Chlordiazepoxide Hydrochloride 0.08 6.25E-06 0.10 1.74E-08 Potassium Chloride 0.01 2.52E-01 0.10 9.54E-15 Dimeticone (Barrier) 0.03 4.38E-02 0.10 8.02E-12 Cefradine 0.06 1.02E-02 0.10 4.29E-05 Brimonidine Tartrate -0.05 3.99E-05 0.10 8.31E-15 Trifluoperazine 0.15 1.98E-14 0.10 2.25E-06 Doxepin 0.13 5.32E-08 0.10 8.59E-05 Tizanidine Hydrochloride 0.09 6.08E-09 0.10 1.08E-09 Enalapril Maleate -0.02 4.52E-02 0.09 1.08E-14 Prazosin Hydrochloride 0.10 2.13E-07 0.09 3.75E-06 Hydroxychloroquine Sulfate -0.05 1.99E-05 0.09 1.76E-14 Bumetanide -0.06 1.59E-06 0.09 2.13E-14 Fluconazole -0.10 2.36E-15 0.09 2.36E-14 Gentamicin Sulfate 0.12 1.88E-19 0.09 7.09E-13 Formoterol Fumarate 0.02 1.14E-01 0.09 8.71E-11 Gluten Free/Wheat Free Mixes 0.23 1.21E-25 0.09 4.31E-05 Fexofenadine Hydrochloride -0.06 2.99E-06 0.09 3.10E-14

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Colchicine -0.15 2.71E-37 0.09 3.54E-14 Prucalopride 0.05 7.49E-05 0.09 4.70E-11 Dapsone 0.11 2.59E-08 0.09 5.48E-06 Tamsulosin Hydrochloride -0.21 2.29E-72 0.09 5.30E-14 Lisinopril -0.03 5.64E-03 0.09 6.11E-14 Galantamine 0.07 3.86E-05 0.09 2.28E-08 Celiprolol Hydrochloride 0.10 4.14E-06 0.09 4.76E-05 Minoxidil 0.13 1.63E-11 0.09 4.59E-06 Other Selenium Preps 0.15 1.49E-06 0.09 4.49E-03 Olmesartan Medoxomil/Amlodipine 0.12 1.91E-05 0.09 2.51E-03 Iodine Compounds 0.20 1.46E-13 0.09 1.25E-03 Risedronate Sodium -0.11 2.53E-18 0.09 8.59E-13 Travoprost -0.01 2.87E-01 0.09 2.48E-12 Vitamin A 0.14 1.69E-15 0.09 4.90E-07 Trandolapril 0.14 1.26E-14 0.09 2.16E-06 Hydrogen Peroxide 0.15 1.27E-14 0.09 1.24E-05 Miconazole Nitrate 0.16 4.89E-61 0.09 1.26E-18 Lanthanum Carbonate 0.16 4.39E-10 0.09 6.44E-04 Fluticasone Prop/Azelastine HCl (Nsl) 0.10 1.79E-16 0.09 1.56E-12 Pilocarpine Hydrochloride 0.10 3.00E-12 0.09 3.07E-10 Hyetellose 0.10 1.13E-07 0.09 3.17E-06 Dicycloverine HCl Compound Preparations 0.14 2.43E-11 0.08 6.56E-05 Tamsulosin & Dutasteride Hydrochloride 0.07 9.62E-06 0.08 1.76E-08 Phytomenadione 0.13 4.08E-12 0.08 1.36E-05 Alprostadil 0.05 1.07E-04 0.08 1.01E-10 Sodium Clodronate 0.09 3.44E-03 0.08 7.03E-03 Repaglinide 0.21 1.62E-26 0.08 2.77E-05 Alogliptin/Metformin 0.21 1.12E-14 0.08 1.99E-03 Prednisolone Sodium Phosphate 0.05 8.44E-07 0.08 1.15E-14 Hydralazine Hydrochloride 0.13 2.18E-22 0.08 2.99E-09 Lidocaine Hydrochloride 0.23 2.31E-51 0.08 5.66E-08 Leflunomide -0.01 3.38E-01 0.08 1.74E-09 Atenolol With Calcium Channel Blocker 0.11 4.24E-04 0.08 9.54E-03 Calcitriol 0.10 1.22E-14 0.08 7.72E-11 Cimetidine 0.04 3.93E-03 0.08 1.09E-07 Desloratadine 0.00 8.01E-01 0.08 2.95E-10 Brinzolamide & Timolol -0.08 8.98E-09 0.08 7.81E-10 Vigabatrin 0.17 1.46E-09 0.08 5.68E-03 Solifenacin/Tamsulosin 0.09 2.05E-06 0.08 2.81E-05 Ciprofibrate 0.10 6.59E-05 0.08 1.54E-03 Fosinopril Sodium 0.18 8.95E-11 0.08 4.85E-03 Bezafibrate -0.02 5.95E-02 0.08 6.85E-10

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Levofloxacin 0.10 1.78E-14 0.08 4.12E-10 Apraclonidine 0.22 8.70E-38 0.08 5.60E-06 Valsartan/Amlodipine 0.16 6.80E-12 0.08 5.72E-04 Propylthiouracil 0.11 3.57E-13 0.08 6.20E-07 Magnesium Glycerophosphate 0.07 1.45E-05 0.08 4.74E-06 Acetylcysteine 0.11 4.13E-13 0.08 1.74E-07 Loteprednol Etabonate 0.11 8.19E-09 0.08 2.24E-05 Metronidazole 0.03 7.18E-05 0.08 5.89E-27 Magnesium Citrate 0.11 3.15E-04 0.08 1.39E-02 Levocetirizine 0.07 3.76E-06 0.08 4.43E-07 Linagliptin/Metformin 0.22 8.35E-19 0.08 1.87E-03 Meptazinol Hydrochloride 0.10 1.89E-05 0.08 1.16E-03 Isosorbide Dinitrate 0.16 1.20E-20 0.08 7.94E-06 Fluocinonide 0.16 4.29E-14 0.08 2.78E-04 Hydrocortisone 0.05 8.31E-17 0.08 6.27E-32 Etoricoxib -0.01 3.63E-01 0.08 1.12E-09 Vortioxetine 0.07 1.51E-05 0.08 1.91E-06 Oxytetracycline -0.14 1.86E-28 0.08 1.07E-09 Emulsifying Wax 0.23 1.16E-58 0.07 2.34E-07 Acenocoumarol 0.16 1.30E-12 0.07 7.43E-04 Acarbose 0.17 1.59E-15 0.07 6.54E-04 Perindopril Arginine 0.10 2.51E-07 0.07 2.38E-04 Simvastatin & Ezetimibe 0.16 1.58E-09 0.07 5.68E-03 Gluten Free Mixes 0.01 6.66E-01 0.07 9.43E-06 Low Protein Mixes 0.13 1.11E-06 0.07 7.54E-03 Terazosin Hydrochloride 0.05 4.73E-03 0.07 5.19E-05 Torasemide 0.14 3.16E-07 0.07 1.06E-02 Perindopril Arginine with Diuretic 0.10 1.78E-06 0.07 3.88E-04 Gluten Free/Wheat Free Bread 0.14 1.22E-07 0.07 8.67E-03 Carbomer 0.09 9.88E-06 0.07 8.44E-04 Valsartan 0.00 7.57E-01 0.07 1.83E-08 Modafinil 0.05 8.52E-04 0.07 4.40E-06 Oils For The Ear 0.23 3.55E-24 0.07 2.49E-03 Vitamin E 0.11 3.11E-11 0.07 5.39E-05 Leuprorelin Acetate -0.11 3.01E-16 0.07 1.85E-07 Trimipramine Maleate 0.13 4.79E-08 0.07 3.78E-03 Phenytoin 0.14 4.46E-10 0.07 2.69E-03 Co-Tenidone (Atenolol/Chlortalidone) 0.04 3.09E-03 0.07 2.89E-06 Meloxicam -0.06 6.41E-06 0.07 1.93E-07 Dithranol 0.18 2.33E-14 0.07 4.84E-03 Ciclesonide 0.03 4.89E-02 0.07 7.91E-05 Cetrimide 0.21 7.88E-19 0.07 4.55E-03

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Acrivastine 0.03 7.62E-02 0.07 1.96E-05 Eslicarbazepine Acetate 0.12 9.14E-06 0.07 1.53E-02 Ascorbic Acid 0.07 1.66E-06 0.07 2.33E-05 Nizatidine 0.05 2.60E-02 0.07 1.23E-03 Brinzolamide -0.21 2.51E-70 0.07 6.50E-08 Memantine Hydrochloride -0.09 3.26E-12 0.07 1.48E-07 Ferrous Gluconate -0.01 3.25E-01 0.07 5.19E-07 Eprosartan 0.14 8.54E-11 0.06 3.11E-03 Telmisartan with Diuretic 0.11 1.97E-08 0.06 1.42E-03 Vardenafil 0.06 6.84E-06 0.06 4.59E-06 Brinzolamide/Brimonidine -0.01 4.78E-01 0.06 1.43E-06 Tetracycline 0.06 7.93E-05 0.06 5.22E-05 Dapoxetine Hydrochloride 0.23 8.31E-22 0.06 1.08E-02 Nitrofurantoin -0.24 1.12E-91 0.06 1.85E-07 Irbesartan with Diuretic 0.13 2.24E-17 0.06 5.84E-05 Moclobemide 0.10 2.49E-04 0.06 2.99E-02 Amiodarone Hydrochloride -0.09 2.06E-13 0.06 4.54E-07 Azelastine Hydrochloride 0.06 7.79E-10 0.06 7.78E-10 Prednisolone -0.02 1.79E-02 0.06 1.01E-12 Urea Hydrogen Peroxide 0.17 1.89E-27 0.06 9.16E-05 Zolpidem Tartrate 0.01 2.29E-01 0.06 1.07E-06 Griseofulvin 0.27 1.10E-23 0.06 2.55E-02 Dexamethasone Phosphate 0.06 2.06E-03 0.06 3.38E-03 Ulipristal Acetate (Emergency Cont) 0.10 6.17E-13 0.06 6.80E-06 Frovatriptan 0.04 2.49E-02 0.06 1.51E-04 Antazoline 0.13 3.56E-12 0.06 2.22E-03 Lormetazepam 0.06 1.56E-02 0.06 1.64E-02 Ethosuximide 0.07 5.04E-05 0.06 1.33E-03 Fluticasone Propionate (Top) 0.12 5.11E-07 0.06 1.60E-02 Norethisterone 0.05 6.96E-10 0.06 1.49E-11 Ibandronic Acid -0.05 3.44E-04 0.06 4.33E-05 Indoramin 0.04 3.44E-02 0.06 4.84E-03 Testosterone Undecanoate -0.05 5.98E-05 0.06 7.60E-06 Diclofenac Sodium 0.01 1.94E-01 0.06 3.37E-16 Empagliflozin/Metformin 0.16 6.87E-10 0.06 3.30E-02 Methenamine Hippurate 0.00 8.27E-01 0.06 7.23E-04 Rivaroxaban -0.21 1.19E-67 0.06 4.01E-06 Other Psoriasis Preps 0.12 2.73E-05 0.06 6.28E-02 Oxcarbazepine 0.09 1.78E-08 0.06 2.83E-04 Other Enzyme Preps 0911020 0.12 5.34E-11 0.05 2.52E-03 Ciclosporin 0.06 7.20E-04 0.05 1.10E-03 Agomelatine 0.08 1.41E-03 0.05 4.71E-02

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Insulin Detemir 0.00 7.65E-01 0.05 1.42E-05 Potassium Permanganate 0.13 2.80E-13 0.05 2.76E-03 Quinapril Hydrochloride 0.12 6.50E-05 0.05 8.53E-02 Valsartan with Diuretic 0.10 5.89E-10 0.05 1.74E-03 Metformin Hydrochloride/Sitagliptin 0.23 2.89E-43 0.05 1.81E-03 Omega-3-Acid Ethyl Esters 0.09 1.41E-09 0.05 1.05E-03 Latanoprost & Timolol -0.16 7.11E-39 0.05 7.52E-05 Olmesartan Medoxomil -0.02 1.25E-01 0.05 3.11E-04 Testosterone Enantate 0.08 1.98E-03 0.05 5.58E-02 Metformin Hydrochloride/Pioglitazone 0.16 5.11E-10 0.05 4.96E-02 Cefuroxime Axetil 0.11 2.22E-05 0.05 6.75E-02 Lodoxamide Trometamol 0.09 5.29E-07 0.05 1.05E-02 Dornase Alfa 0.11 1.22E-04 0.05 9.75E-02 Mesalazine (Systemic) -0.17 5.27E-48 0.05 7.89E-05 Bromocriptine 0.07 3.53E-03 0.05 3.89E-02 Escitalopram -0.06 6.68E-07 0.05 1.12E-04 Mycophenolate Mofetil 0.01 6.20E-01 0.05 6.26E-04 Candesartan Cilexetil -0.18 2.25E-51 0.05 1.81E-04 Compound Alginates&Prop Indigestion Prep 0.13 3.33E-06 0.04 1.21E-01 Triamcinolone Acetonide -0.04 1.63E-03 0.04 9.72E-05 Timolol & Brimonidine 0.03 1.28E-01 0.04 9.45E-03 Artificial Saliva 0.12 4.11E-08 0.04 5.12E-02 Methotrexate -0.10 6.33E-21 0.04 9.90E-05 Lisinopril with Diuretic 0.09 8.53E-08 0.04 8.53E-03 Silver Nitrate 0.13 9.65E-14 0.04 1.74E-02 Dutasteride -0.06 2.45E-06 0.04 1.66E-03 Phenelzine Sulfate 0.05 9.61E-02 0.04 1.83E-01 Ergocalciferol 0.06 9.47E-05 0.04 9.17E-03 Levobunolol Hydrochloride 0.07 2.13E-04 0.04 4.11E-02 Erythromycin Stearate 0.14 6.83E-15 0.04 2.69E-02 Clindamycin Hydrochloride -0.03 3.24E-02 0.04 2.02E-03 Dorzolamide & Timolol -0.12 8.69E-25 0.04 1.09E-03 Other Calcium Supplement Preps 0.13 1.51E-12 0.04 3.31E-02 Olsalazine Sodium 0.09 2.21E-03 0.04 1.76E-01 Magnesium Sulfate 0.12 1.91E-09 0.04 6.61E-02 Paliperidone 0.13 3.48E-05 0.04 2.27E-01 Megestrol Acetate 0.06 4.24E-02 0.04 2.30E-01 Enalapril Maleate with Diuretic 0.08 2.53E-03 0.04 1.57E-01 Budesonide 0.02 2.38E-02 0.04 1.05E-06 Tocopheryl Acetate 0.12 5.18E-06 0.04 1.48E-01 Midodrine Hydrochloride 0.01 6.47E-01 0.04 1.35E-02 Desogestrel -0.18 1.70E-49 0.04 2.71E-03

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Influenza -0.23 1.86E-78 0.04 3.39E-03 Glycerol -0.06 7.90E-08 0.04 3.33E-03 Glibenclamide 0.16 5.38E-10 0.04 1.73E-01 Cinacalcet Hydrochloride 0.10 3.81E-08 0.04 5.78E-02 Colestyramine -0.11 1.43E-18 0.03 6.14E-03 Raloxifene Hydrochloride 0.03 7.99E-02 0.03 5.25E-02 Tacrolimus 0.10 6.78E-25 0.03 3.82E-04 Sodium Fluoride 0.01 5.31E-01 0.03 1.37E-02 Chlortalidone 0.07 5.67E-03 0.03 2.00E-01 Somatropin 0.08 1.40E-06 0.03 4.62E-02 Olmesartan Medoxomil/Hydrochlorothiazide 0.06 1.90E-02 0.03 2.06E-01 Brimonidine Tart (Rosacea) 0.09 9.08E-06 0.03 8.21E-02 Other Treatment of Dry Mouth Preps 0.03 3.50E-01 0.03 2.14E-01 Fluticasone Furoate -0.09 5.58E-13 0.03 5.65E-03 Riboflavin 0.11 5.61E-05 0.03 2.25E-01 Telmisartan -0.01 6.45E-01 0.03 1.24E-02 Famotidine 0.03 2.07E-01 0.03 1.40E-01 Naratriptan Hydrochloride -0.10 8.78E-15 0.03 1.55E-02 Co-Proxamol (Dextroprop HCl/Paracet) 0.07 2.35E-02 0.03 2.75E-01 Midazolam Maleate 0.04 3.17E-02 0.03 6.59E-02 Riluzole 0.06 1.02E-02 0.03 1.47E-01 Lacidipine -0.03 2.05E-02 0.03 2.10E-02 Aliskiren 0.11 8.51E-05 0.03 2.52E-01 Selegiline Hydrochloride 0.04 7.54E-02 0.03 1.80E-01 Methylphenidate Hydrochloride -0.04 3.50E-04 0.03 1.50E-02 Paraffin Yellow Soft 0.05 4.30E-03 0.03 1.18E-01 Dalteparin Sodium -0.01 3.68E-01 0.03 6.58E-02 Metformin Hydrochloride/Vildagliptin 0.19 1.77E-16 0.03 2.38E-01 Tibolone -0.09 1.56E-11 0.03 4.01E-02 Fluvastatin Sodium 0.00 8.18E-01 0.03 9.92E-02 Estradiol and Estriol with Progestogen 0.06 1.04E-02 0.03 2.70E-01 Hydrocortisone Sodium Succinate 0.05 7.82E-03 0.03 2.03E-01 Vancomycin Hydrochloride 0.09 8.76E-05 0.03 3.00E-01 Ketorolac Trometamol 0.04 2.53E-03 0.02 7.74E-02 Indometacin -0.05 2.60E-04 0.02 6.63E-02 Tafluprost & Timolol 0.02 2.93E-01 0.02 2.94E-01 Diclofenac Potassium 0.09 2.65E-06 0.02 2.11E-01 Vildagliptin 0.09 5.77E-06 0.02 2.61E-01 Dexamfetamine Sulfate 0.07 1.08E-04 0.02 2.19E-01 Heparin Flushes 0.11 1.55E-06 0.02 3.08E-01 Dexamethasone -0.05 2.18E-12 0.02 9.82E-04 Betamethasone Esters 0.05 6.77E-05 0.02 6.13E-02

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Losartan Potassium -0.09 3.07E-14 0.02 6.25E-02 Mercaptopurine -0.01 4.62E-01 0.02 1.58E-01 Cyclizine Lactate -0.05 5.40E-04 0.02 1.52E-01 Aciclovir 0.01 9.75E-02 0.02 4.62E-03 Other Health Supplement Preps 0.11 1.94E-06 0.02 3.63E-01 Anastrozole -0.17 2.67E-39 0.02 9.20E-02 Tioconazole 0.05 3.61E-03 0.02 2.55E-01 Dorzolamide -0.14 6.60E-28 0.02 9.54E-02 Finasteride -0.26 1.61E-108 0.02 9.53E-02 Dapagliflozin/Metformin 0.12 7.76E-06 0.02 4.55E-01 Almotriptan 0.00 8.38E-01 0.02 2.66E-01 Nicotinamide 0.09 2.12E-03 0.02 4.92E-01 Hydrocortisone Acetate 0.04 6.52E-06 0.02 2.77E-02 Rifampicin 0.01 7.07E-01 0.02 3.10E-01 Acitretin 0.01 6.75E-01 0.02 5.48E-01 Hepatitis B 0.09 3.08E-13 0.02 1.53E-01 Prochlorperazine Mesilate 0.04 2.31E-02 0.02 3.48E-01 Fusidic Acid 0.02 2.30E-02 0.02 4.21E-02 Other Digestive Aid Preps 0.06 7.26E-03 0.02 4.27E-01 Propafenone Hydrochloride 0.02 4.77E-01 0.02 4.69E-01 Flumetasone Pivalate 0.01 4.36E-01 0.02 3.01E-01 Exemestane -0.11 1.14E-16 0.02 2.37E-01 Methylcellulose 0.03 2.19E-01 0.01 5.77E-01 Fluticasone Propionate (Nsl) -0.15 4.72E-34 0.01 2.41E-01 Disopyramide 0.06 3.92E-02 0.01 6.07E-01 Rosuvastatin Calcium -0.19 2.43E-57 0.01 2.53E-01 Fludroxycortide 0.01 6.02E-01 0.01 3.31E-01 Lixisenatide 0.04 6.87E-02 0.01 5.22E-01 Menadiol Sodium Phosphate 0.08 1.55E-03 0.01 6.15E-01 Bromfenac 0.08 1.99E-04 0.01 5.38E-01 Doxycycline Monohydrate 0.02 4.43E-01 0.01 5.69E-01 Hydrocortisone Sodium Phosphate 0.05 5.94E-03 0.01 4.87E-01 Letrozole -0.15 7.75E-35 0.01 3.59E-01 Bimatoprost -0.21 3.57E-69 0.01 3.89E-01 Tafluprost -0.06 5.22E-05 0.01 5.03E-01 Clomifene Citrate 0.14 3.16E-06 0.01 7.36E-01 Colestipol Hydrochloride 0.03 1.72E-01 0.01 6.66E-01 Amantadine Hydrochloride -0.05 1.17E-03 0.01 5.35E-01 Clarithromycin -0.14 1.23E-32 0.01 4.91E-01 Other Amino Acid&Nutritional Agent Preps 0.10 5.87E-07 0.01 7.21E-01 Co-Beneldopa (Benserazide/Levodopa) -0.21 1.53E-67 0.01 5.72E-01 Erythromycin -0.03 6.75E-04 0.00 5.95E-01

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Methylprednisolone 0.07 1.73E-03 0.00 8.43E-01 Minocycline Hydrochloride 0.01 7.00E-01 0.00 8.12E-01 Mometasone Furoate -0.06 2.84E-14 0.00 6.95E-01 Co-Amilozide (Amiloride HCl/Hydchloroth) -0.03 3.74E-02 0.00 8.70E-01 Timolol & Travoprost -0.09 5.15E-11 0.00 8.59E-01 Entacapone 0.02 2.60E-01 0.00 9.30E-01 Losartan Potassium With Diuretic 0.09 7.04E-10 0.00 9.17E-01 Terbinafine Hydrochloride -0.01 4.66E-01 0.00 8.83E-01 Alkyl Sulphate 0.09 2.48E-06 0.00 9.64E-01 Ephedrine Hydrochloride 0.09 2.46E-04 0.00 9.87E-01 Prednisolone Sodium Metasulphobenzoate 0.01 6.44E-01 0.00 9.86E-01 Rasagiline Mesilate -0.10 5.12E-13 0.00 9.54E-01 Benzoyl Peroxide & Clindamycin Phosphate 0.09 3.58E-13 0.00 9.34E-01 Rotigotine -0.08 3.61E-09 0.00 8.32E-01 Other Oral Iron Preps 0.03 2.63E-01 0.00 9.01E-01 Pneumococcal -0.10 1.75E-17 -0.01 6.30E-01 Testosterone Esters -0.01 5.52E-01 -0.01 7.10E-01 Glipizide 0.01 5.56E-01 -0.01 7.57E-01 Podophyllotoxin 0.13 6.02E-12 -0.01 6.60E-01 Bicalutamide -0.15 1.08E-31 -0.01 4.89E-01 Other Eye Tear/Lubricant/AstringentPreps -0.06 4.34E-04 -0.01 5.93E-01 Ganciclovir 0.01 6.25E-01 -0.01 6.59E-01 Carmellose Sodium -0.07 3.51E-08 -0.01 4.29E-01 Cefaclor 0.02 3.41E-01 -0.01 6.55E-01 Triptorelin Acetate -0.06 1.33E-04 -0.01 4.77E-01 Mupirocin -0.04 2.28E-06 -0.01 2.01E-01 Cabergoline 0.04 3.15E-03 -0.01 3.46E-01 Timolol & Bimatoprost -0.25 2.56E-99 -0.01 3.24E-01 Clindamycin Phosphate 0.02 4.82E-02 -0.01 1.65E-01 Lisdexamfetamine Dimesylate 0.03 2.45E-02 -0.01 3.12E-01 Testosterone -0.13 2.06E-27 -0.01 2.47E-01 Oestrogens Conjugated -0.14 1.28E-28 -0.02 2.19E-01 Nepafenac 0.11 1.36E-09 -0.02 3.98E-01 Imiquimod -0.09 9.84E-09 -0.02 2.51E-01 Ketotifen Fumarate 0.03 1.12E-01 -0.02 3.09E-01 Sodium Fusidate 0.05 1.99E-04 -0.02 1.88E-01 Potassium Citrate 0.03 7.82E-02 -0.02 2.78E-01 Azathioprine -0.16 1.22E-40 -0.02 6.85E-02 Betaxolol 0.00 9.18E-01 -0.02 3.04E-01 Phased Formulations Of Ethinylestradiol -0.02 2.52E-01 -0.02 7.40E-02 Other Comp Vit/Mineral Formulation Preps 0.03 5.89E-02 -0.03 4.97E-02 Fluocortolone 0.02 3.63E-01 -0.03 2.07E-01

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Fluorometholone -0.05 9.20E-05 -0.03 3.25E-02 Dabigatran Etexilate -0.18 1.10E-45 -0.03 1.96E-02 Itraconazole -0.04 9.30E-04 -0.03 1.41E-02 Azelaic Acid -0.04 4.18E-04 -0.03 1.39E-02 Iron & Folic Acid 0.05 4.88E-03 -0.03 6.69E-02 Ciprofloxacin -0.04 1.81E-08 -0.03 1.18E-05 Levodopa/Carbidopa/Entacapone -0.08 3.03E-07 -0.03 1.95E-02 Moxifloxacin 0.05 7.95E-02 -0.04 2.05E-01 Cetomacrogol 0.12 4.64E-06 -0.04 1.61E-01 Hydroxycarbamide -0.11 1.62E-12 -0.04 1.20E-02 INR Blood Testing Reagents -0.07 1.63E-05 -0.04 1.32E-02 Levonorgestrel -0.06 2.00E-13 -0.04 3.02E-07 Magnesium Hydroxide -0.10 7.09E-05 -0.04 9.72E-02 Oestrogens Conjugated with Progestogen -0.02 2.63E-01 -0.04 2.68E-03 Ingenol Mebutate -0.12 1.11E-10 -0.04 2.15E-02 Timolol -0.14 4.80E-37 -0.05 8.08E-05 Pimecrolimus 0.03 5.57E-02 -0.05 5.34E-04 Ofloxacin -0.03 2.86E-03 -0.05 1.62E-05 Eletriptan -0.05 5.56E-02 -0.05 5.22E-02 Betamethasone Sodium Phosphate -0.07 2.94E-16 -0.05 4.81E-10 Donepezil Hydrochloride -0.22 1.11E-77 -0.05 2.85E-05 Sterculia -0.07 1.27E-05 -0.05 2.15E-03 Rivastigmine -0.16 4.50E-37 -0.05 4.11E-05 Econazole Nitrate 0.03 1.73E-01 -0.05 7.29E-03 Estradiol Val&Estradiol Val + Dienogest 0.00 8.39E-01 -0.06 5.64E-03 Hydrocortisone (Sodium Succinate) -0.09 1.37E-11 -0.06 1.36E-05 Clindamycin/Tretinoin 0.06 2.61E-04 -0.06 1.87E-04 Sotalol Hydrochloride -0.22 1.82E-71 -0.06 8.38E-07 Liothyronine Sodium -0.09 1.61E-07 -0.07 1.90E-04 Famciclovir -0.06 2.71E-02 -0.07 1.15E-02 Estradiol Valerate -0.16 5.41E-37 -0.07 1.23E-07 Valaciclovir -0.07 3.20E-05 -0.07 2.11E-06 Cholera -0.03 1.56E-01 -0.08 1.80E-03 Triptorelin Embonate -0.06 3.73E-02 -0.08 2.17E-03 Edoxaban -0.14 5.51E-27 -0.08 1.37E-10 Olopatadine 0.03 1.32E-02 -0.09 8.04E-14 Co-Amoxiclav (Amoxicillin/Clavul Acid) -0.21 9.73E-67 -0.10 1.07E-15 Rizatriptan -0.26 1.10E-99 -0.11 5.30E-19 Hepatitis A 0.07 3.58E-09 -0.11 5.80E-21 Estriol -0.37 8.88E-221 -0.12 1.64E-21 Etonogestrel/Ethinylestradiol 0.12 1.02E-11 -0.12 2.18E-10 Dexamethasone Sodium Metasulphobenzoate -0.13 9.09E-28 -0.12 6.91E-23

rho p value rho p value Drug / Chemical Name (unadjusted) (unadjusted) (adjusted) (adjusted) Zolmitriptan -0.31 1.48E-142 -0.12 6.25E-23 Hepatitis A/Hepatitis B -0.07 1.32E-05 -0.12 4.49E-13 Lymecycline -0.25 2.83E-98 -0.13 8.22E-26 Tamoxifen Citrate -0.32 4.95E-162 -0.13 2.86E-26 Adapalene & Benzoyl Peroxide -0.10 3.49E-16 -0.13 3.88E-27 Fluorouracil (Sunscreen) -0.36 1.06E-192 -0.15 4.37E-31 Goserelin Acetate -0.22 2.47E-70 -0.15 1.75E-32 Co-Careldopa (Carbidopa/Levodopa) -0.32 1.25E-156 -0.15 8.94E-36 Co-Cyprindiol (Cyprote Acet/Ethinlestr) -0.12 4.86E-23 -0.16 1.54E-36 Isoniazid 0.06 7.63E-02 -0.16 4.92E-07 Denosumab -0.25 1.29E-57 -0.16 1.59E-23 Bupropion Hydrochloride -0.09 6.70E-06 -0.16 1.30E-17 Flecainide Acetate -0.35 1.63E-181 -0.17 1.09E-42 Adapalene -0.15 7.73E-37 -0.19 2.68E-54 Combined Ethinylestradiol 35mcg -0.30 2.94E-145 -0.22 5.15E-77 Diphtheria -0.22 7.31E-64 -0.23 8.00E-71 Hepatitis A/Typhoid Vaccine -0.15 1.67E-22 -0.24 2.31E-56 Combined Ethinylestradiol 20mcg -0.30 2.23E-143 -0.25 3.20E-98 Typhoid -0.07 4.55E-09 -0.25 4.29E-99 Estradiol with Progestogen -0.50 <1.00E-300 -0.29 6.69E-138 Estradiol -0.51 <1.00E-300 -0.30 1.27E-288 Combined Ethinylestradiol 30mcg -0.41 8.96E-277 -0.31 1.57E-156 Progesterone -0.42 4.29E-250 -0.38 6.57E-205 Adrenaline -0.52 <1.00E-300 -0.48 <1.00E-300

Table S4. List of all drug classes analysed with correlation coefficients and p values.

Ordered from the most positive adjusted correlation coefficient to the most negative. Original British National Formulary paragraph names given.

rho p value rho p value Drug Class Name (unadjusted) (unadjusted) (adjusted) (adjusted) Non-Opioid Analgesics And Compound Prep 0.43 1.47E-303 0.67 <1.00E-300 Adrenoceptor Agonists 0.46 <1.00E-300 0.64 <1.00E-300 Opioid Analgesics 0.26 8.19E-110 0.57 <1.00E-300 Control Of Epilepsy 0.37 4.58E-218 0.56 <1.00E-300 Antimuscarinic Bronchodilators 0.32 3.51E-163 0.56 <1.00E-300 Antispasmod.&Other Drgs Alt.Gut Motility 0.30 1.59E-139 0.54 <1.00E-300 Rubefacients,Top NSAIDS,Capsaicin & Poul 0.40 7.20E-267 0.52 <1.00E-300 Corticosteroids (Respiratory) 0.27 1.59E-116 0.52 <1.00E-300 Nitrates 0.31 1.24E-150 0.52 <1.00E-300 Drugs Used In Nausea And Vertigo 0.27 8.24E-118 0.51 <1.00E-300 Compound Alginates&Prop Indigestion Prep 0.34 3.66E-187 0.50 <1.00E-300 Other Antidepressant Drugs 0.30 2.92E-143 0.50 <1.00E-300 Antipsychotic Drugs 0.49 <1.00E-300 0.49 <1.00E-300 Shampoo&Other Preps For Scalp&Hair Cond 0.48 <1.00E-300 0.48 <1.00E-300 Tricyclic & Related Antidepressant Drugs 0.22 1.54E-73 0.47 <1.00E-300 Mucolytics 0.29 9.17E-137 0.47 <1.00E-300 Insulin 0.32 2.33E-163 0.45 <1.00E-300 Other Antianginal Drugs 0.31 1.87E-149 0.45 <1.00E-300 Parasiticidal Preparations 0.50 <1.00E-300 0.44 <1.00E-300 Antidiabetic Drugs 0.46 <1.00E-300 0.44 <1.00E-300 Proton Pump Inhibitors 0.12 1.18E-24 0.44 <1.00E-300 Vaginal and Vulval Infections 0.47 <1.00E-300 0.44 <1.00E-300 Diabetic Diagnostic & Monitoring Agents 0.34 8.50E-192 0.44 <1.00E-300 Drugs For Oral Ulceration & Inflammation 0.41 6.47E-275 0.43 1.55E-299 Compound Bronchodilator Preparations 0.20 7.66E-62 0.42 6.11E-294 Antimuscarinic Drugs Used In Parkin'ism 0.48 <1.00E-300 0.42 1.40E-290 Theophylline 0.36 3.50E-206 0.42 9.49E-285 Selective Serotonin Re-Uptake Inhibitors 0.14 2.65E-32 0.42 5.56E-286 Antimotility Drugs 0.07 3.70E-09 0.41 1.85E-274 Vitamin B Group 0.43 4.32E-306 0.41 1.22E-271 Antiplatelet Drugs 0.13 2.84E-28 0.40 6.87E-258 Tear Deficiency,Eye Lubricant/Astringent 0.21 1.00E-72 0.39 4.26E-255 Lipid-Regulating Drugs 0.14 3.03E-33 0.38 1.83E-240 Preparations For Psoriasis 0.26 2.86E-104 0.38 1.96E-239 Iron-Deficiency Anaemias 0.35 1.96E-202 0.38 3.25E-238

rho p value rho p value Drug Class Name (unadjusted) (unadjusted) (adjusted) (adjusted) Antihistamines 0.28 1.81E-124 0.38 1.17E-236 Drugs/Urin'y Frequ'cy Enuresis & Incont 0.14 8.28E-32 0.38 1.43E-236 Enteral Nutrition 0.25 1.75E-101 0.38 1.75E-234 Beta-Adrenoceptor Blocking Drugs 0.04 2.49E-03 0.38 9.08E-232 Osmotic Laxatives 0.05 1.45E-05 0.37 6.64E-220 Gastro-Intestinal Anti-Obesity Drugs 0.41 5.58E-264 0.36 6.29E-208 Multivitamin Preparations 0.41 1.35E-279 0.36 2.13E-212 Emollients 0.35 1.31E-198 0.36 4.20E-211 Leukotriene Receptor Antagonists 0.22 1.00E-74 0.36 1.46E-209 Polyene Antifungals 0.23 3.53E-83 0.36 5.63E-207 Loop Diuretics 0.05 1.19E-04 0.36 2.11E-205 Non-Steroidal Anti-Inflammatory Drugs 0.17 4.70E-46 0.35 6.54E-203 Stimulant Laxatives 0.28 8.17E-126 0.35 5.52E-201 Drugs used in Megaloblastic Anaemias 0.14 1.73E-32 0.34 1.65E-191 Antimalarials 0.16 4.09E-42 0.34 1.10E-186 Glucocorticoid Therapy -0.06 6.49E-07 0.33 2.06E-170 Soothing Haemorrhoidal Preparations 0.34 4.50E-182 0.32 1.12E-160 Top Local Anaesthetics & Antipruritics 0.26 3.89E-104 0.31 1.16E-156 Antiperspirants 0.33 5.61E-154 0.31 1.94E-137 Calcium-Channel Blockers 0.05 7.57E-05 0.30 4.51E-145 Metronidazole, Tinidazole & Ornidazole 0.24 8.86E-91 0.30 4.46E-143 Tetracyclines -0.03 1.85E-02 0.30 2.51E-141 Drugs For Erectile Dysfunction 0.08 2.02E-11 0.29 1.98E-137 Skeletal Muscle Relaxants 0.12 1.32E-24 0.29 2.46E-134 Topical Corticosteroids 0.17 1.46E-47 0.29 2.77E-133 Anxiolytics 0.08 1.88E-10 0.29 5.40E-131 Oral Prepn for Fluid & Electrolyte Imb 0.33 1.31E-170 0.29 7.68E-130 H2-Receptor Antagonists 0.08 3.86E-12 0.28 4.25E-126 Renin-Angiotensin System Drugs 0.00 7.89E-01 0.28 6.62E-126 Drugs For Threadworms 0.36 7.82E-212 0.27 3.18E-116 Mouth-Washes, Gargles, And Dentifrices 0.27 4.21E-106 0.27 1.80E-111 Drugs Used for Mania and Hypomania 0.17 2.57E-43 0.27 1.01E-115 Topical Nasal Decongestants 0.10 2.74E-17 0.27 3.65E-113 Barrier Preparations 0.16 9.28E-38 0.27 1.09E-109 Antifungal Preparations 0.22 2.04E-79 0.26 1.54E-109 Alcohol Dependence 0.27 2.38E-85 0.26 1.43E-79 Preparations For Warts And Calluses 0.38 1.27E-229 0.26 1.85E-107 Peripheral Vasodilators & Related Drugs 0.25 2.64E-73 0.26 4.65E-80 Antimigraine Drugs -0.04 4.81E-04 0.26 2.70E-106 Thiazides And Related Diuretics -0.03 8.03E-03 0.25 1.03E-102 Penicillins 0.14 3.67E-31 0.25 4.60E-102 Chlorhexidine Salts 0.28 3.60E-116 0.25 2.87E-95

rho p value rho p value Drug Class Name (unadjusted) (unadjusted) (adjusted) (adjusted) Pancreatin 0.08 2.30E-11 0.25 3.20E-95 Vitamin D 0.10 8.63E-17 0.25 2.97E-95 Calcium And Magnesium 0.17 1.82E-46 0.24 2.11E-90 Oropharyngeal Anti-Infective Drugs 0.18 1.25E-50 0.24 1.09E-88 Pot-Sparing Diuretics&Aldosterone Antag 0.03 1.48E-02 0.24 9.43E-91 Centrally-Acting Antihypertensive Drugs 0.14 3.93E-31 0.24 1.20E-84 Alpha-Adrenoceptor Blocking Drugs 0.13 5.28E-26 0.24 5.18E-89 Hypnotics 0.06 1.77E-07 0.24 4.99E-88 Antacids and Simeticone 0.26 7.13E-96 0.24 6.40E-76 Phosphorus 0.30 4.85E-126 0.23 1.40E-73 Foods For Special Diets 0.13 1.92E-28 0.23 1.83E-80 Expectorant & Demulcent Cough Prep's 0.37 1.09E-172 0.22 6.26E-60 Antiviral Preparations 0.16 2.31E-40 0.22 2.47E-72 Gout & Cytotoxic Induced Hyperuicaemia -0.11 1.11E-18 0.21 1.28E-70 Sulfonamides And Trimethoprim -0.08 3.58E-11 0.21 6.14E-69 Antifibrinolytic Drugs & Haemostatics 0.23 7.41E-83 0.21 1.89E-66 Cough Suppressants 0.18 7.52E-50 0.20 3.72E-60 Drugs Affecting Biliary Composition&Flow 0.05 1.49E-05 0.20 2.06E-58 Antithyroid Drugs 0.14 2.48E-31 0.20 1.89E-61 Treatment Of Hypoglycaemia 0.05 7.36E-05 0.20 3.37E-60 Some Other Antibiotics 0.07 1.97E-08 0.19 2.34E-50 Camouflagers 0.28 3.53E-80 0.18 3.25E-34 Parenteral Anticoagulants -0.02 1.14E-01 0.18 5.55E-48 Posterior Pituitary Hormones&Antagonists 0.03 2.21E-02 0.17 2.71E-44 Macrolides 0.00 8.75E-01 0.17 7.98E-46 Systemic Nasal Decongestants 0.25 1.10E-58 0.17 1.26E-26 Nicotine Dependence 0.15 3.72E-37 0.16 5.91E-41 Otitis Externa 0.00 9.73E-01 0.16 2.31E-41 Cardiac Glycosides -0.18 2.66E-49 0.16 1.88E-40 Medicated Stockings 0.13 3.78E-10 0.16 3.92E-14 Aminosalicylates -0.12 3.56E-24 0.16 1.21E-39 Oral Anticoagulants -0.25 6.32E-96 0.15 6.45E-38 Zinc & other Minerals 0.17 6.55E-24 0.15 3.27E-20 Drugs Used In Nasal Allergy -0.13 1.20E-26 0.14 1.10E-32 Topical Circulatory Preparations 0.06 7.63E-07 0.14 4.45E-28 Drugs Used In Status Epilepticus 0.10 1.44E-16 0.14 1.22E-29 Mydriatics And Cycloplegics 0.12 1.97E-19 0.14 1.79E-25 Bisphosphonates and Other Drugs -0.19 8.15E-55 0.14 5.03E-31 Foods 0.14 1.46E-29 0.14 1.13E-27 Thyroid Hormones -0.16 1.65E-39 0.13 4.77E-29 Dgs Which Enhance Neuromus'ar Transmi'on 0.11 3.90E-14 0.13 1.67E-20 Essential tremor,Chorea,Tics&Reldisorders 0.15 2.85E-18 0.13 4.33E-15

rho p value rho p value Drug Class Name (unadjusted) (unadjusted) (adjusted) (adjusted) Opioid Dependence 0.20 6.30E-35 0.13 5.16E-15 Peripheral Opioid-Receptor Antagonists 0.16 4.54E-15 0.13 3.80E-10 Other Drugs Used In Constipation 0.07 1.53E-07 0.13 2.07E-22 Antibacterial Preparations 0.06 2.72E-07 0.13 1.09E-25 Influenza 0.15 4.17E-23 0.12 1.74E-15 Parent Prepn for Fluid & Electrolyte Imb -0.16 1.19E-39 0.12 3.43E-24 Prep's For Minor Cuts & Abrasions 0.18 5.07E-30 0.12 8.77E-15 Antibacterials 0.06 4.16E-06 0.12 2.85E-24 Progestogen-only Contraceptives -0.09 3.35E-15 0.12 7.07E-24 Bulk-Forming Laxatives -0.18 4.20E-52 0.12 1.94E-23 Chelates And Complexes 0.14 9.65E-09 0.12 8.88E-07 Replacement Therapy -0.06 1.26E-07 0.11 1.48E-20 Cephalosporins and other Beta-Lactams -0.08 5.65E-11 0.11 3.53E-21 Lozenges & Sprays 0.30 5.81E-34 0.11 1.24E-05 Cromoglycate and Related Therapy 0.12 6.10E-06 0.11 4.78E-05 Drugs For Urinary Retention -0.20 3.34E-65 0.11 2.26E-19 Other Anti-Inflammatory Preparations 0.15 1.13E-37 0.11 3.90E-19 Emergency Contraception 0.13 4.89E-25 0.10 4.01E-16 Vasodilator Antihypertensive Drugs 0.15 1.05E-27 0.10 2.49E-13 Vitamin A 0.15 2.34E-21 0.10 1.19E-09 Antileprotic Drugs 0.11 2.05E-08 0.09 3.83E-06 Preparations For Eczema 0.16 5.49E-08 0.09 2.40E-03 Progestogens 0.09 2.40E-05 0.09 2.49E-05 Antipsychotic Depot Injections 0.13 2.71E-18 0.09 7.73E-09 Nasal Prepn for Infection 0.01 4.65E-01 0.09 4.76E-13 Potassium Sparing Diuretics & Compounds -0.03 2.49E-02 0.09 6.79E-12 Vitamin E 0.12 5.22E-15 0.09 6.28E-08 Co Haemorrhoidal Prep's + Corticosteroid 0.04 1.81E-03 0.09 1.48E-12 Cortico'oids & Other Immunosuppressants 0.05 2.21E-04 0.08 3.62E-09 Aminoglycosides 0.08 9.85E-03 0.08 6.64E-03 Treatment Of Glaucoma -0.28 1.77E-120 0.07 4.71E-10 Bowel Cleansing Preparations 0.13 7.55E-16 0.07 6.99E-06 Removal of Ear Wax & other Substances 0.18 7.68E-39 0.07 2.79E-07 Other Eye Preparations 0.09 1.10E-05 0.07 9.86E-04 Triazole Antifungals -0.10 1.47E-16 0.07 1.05E-08 Vitamin C 0.07 1.66E-06 0.07 2.25E-05 Drugs For Premature Ejaculation 0.23 5.66E-22 0.06 9.28E-03 Urinary-Tract Infections -0.25 2.20E-95 0.06 1.56E-07 Chlorine & Iodine 0.16 7.02E-10 0.06 2.06E-02 Vitamin K 0.11 4.08E-10 0.06 1.19E-03 Enzymes 0.12 4.25E-11 0.05 2.36E-03 Hypoplastic/Haemolytic & Renal Anaemias 0.18 8.93E-12 0.05 6.60E-02

rho p value rho p value Drug Class Name (unadjusted) (unadjusted) (adjusted) (adjusted) Rheumatic Disease Suppressant Drugs -0.22 1.15E-79 0.05 5.16E-05 Oxidisers & Dyes 0.12 3.34E-13 0.05 6.00E-03 Clindamycin and Lincomycin -0.03 3.21E-02 0.04 2.04E-03 Corticosteroids -0.06 2.16E-17 0.04 1.15E-07 Vasoconstrictor Sympathomimetics 0.01 6.47E-01 0.04 1.35E-02 Fluoride 0.01 5.31E-01 0.03 1.37E-02 Amino Acids & Nutritional Agents 0.11 3.08E-08 0.03 1.15E-01 Male Sex Hormones And Antagonists -0.27 8.07E-115 0.03 1.90E-02 Treatment Of Dry Mouth 0.00 8.37E-01 0.03 9.32E-02 Other Health Supplements 0.11 1.94E-06 0.02 3.63E-01 CNS Stimulants and drugs used for ADHD -0.06 2.13E-07 0.02 1.17E-01 Digestive Aids 0.06 7.26E-03 0.02 4.27E-01 Hypothalamic&Ant Pituit Hormone&Antioest 0.04 6.11E-03 0.01 6.50E-01 Dopaminergic Drugs Used In Parkinsonism -0.30 4.46E-140 0.01 5.78E-01 Antimetabolites -0.05 3.75E-04 0.01 7.11E-01 Antiproliferative Immunosuppressants -0.14 3.53E-31 0.00 9.87E-01 Cationic Surfactants & Soaps 0.09 3.19E-06 0.00 9.99E-01 Monoamine-Oxidase Inhibitors (Maois) 0.01 5.14E-01 0.00 8.84E-01 Food Allergy 0.01 6.74E-01 -0.01 7.46E-01 Bromocriptine & Other Dopaminergic Drugs 0.01 5.26E-01 -0.01 5.02E-01 Drugs for Dementia -0.21 1.52E-71 -0.01 3.21E-01 Management of Anal Fissures -0.01 4.77E-01 -0.02 1.64E-01 Drugs Affecting The Immune Response 0.09 3.93E-14 -0.02 8.37E-02 Faecal Softeners 0.10 2.72E-05 -0.02 3.40E-01 Drugs Used In Urological Pain 0.03 1.01E-01 -0.02 1.94E-01 Compound Vit/Mineral Formulations 0.03 5.89E-02 -0.03 4.97E-02 Antivirals -0.06 5.58E-05 -0.03 6.31E-02 Antituberculosis Drugs 0.06 2.47E-04 -0.03 6.71E-02 Ocular Diagnos/Peri-op Prepn&Photodyn Tt 0.02 1.86E-01 -0.04 4.41E-03 Other Antineoplastic Drugs -0.11 2.79E-11 -0.04 2.15E-02 Hormone Antagonists -0.36 1.95E-207 -0.04 1.77E-03 Vaccines And Antisera -0.24 9.01E-90 -0.04 2.28E-04 Other Antifungals -0.09 3.53E-15 -0.04 2.01E-04 Drugs For Arrhythmias -0.29 4.39E-128 -0.06 5.34E-07 Topical Preparation For Rosacea -0.14 2.03E-26 -0.08 3.02E-09 Quinolones -0.26 2.41E-108 -0.08 1.07E-10 Topical Preparations For Acne -0.02 5.34E-02 -0.09 1.73E-13 Sunscreening Preparations -0.38 5.80E-237 -0.11 1.59E-18 Oral Preparations For Acne -0.12 6.33E-22 -0.15 3.28E-35 Vehicles & Emulsifying Agents 0.00 9.00E-01 -0.17 2.39E-14 Herpesvirus Infections -0.37 8.79E-226 -0.17 6.90E-47 Female Sex Hormones & Their Modulators -0.45 <1.00E-300 -0.24 4.82E-94

rho p value rho p value Drug Class Name (unadjusted) (unadjusted) (adjusted) (adjusted) Combined Hormonal Contraceptives/Systems -0.42 8.11E-294 -0.33 1.78E-173 Preparations For Vaginal/Vulval Changes -0.56 <1.00E-300 -0.34 7.58E-181 Allergic Emergencies -0.53 <1.00E-300 -0.49 <1.00E-300

Mooney J, et al. Postgrad Med J 2020;0:1–6. doi: 10.1136/postgradmedj-2020-138944