Donald Pinkel
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Natural Resistance to Methotrexate in Human Melanomas
0022-202X/80/7504-0357$02.00/0 THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, 75:357-359, 1980 Vol. 75, No. 4 Copyright © 1980 by The Williams & Wilkins Co. Printed in U.S.A. Natural Resistance to Methotrexate in Human Melanomas DONALD W. KUFE, M .D ., MICHAEL M. WICK, M .D., PH.D., AND HERBERT T. ABELSON, M.D. Divisions of Pharmacology and Medical Onco logy (DWK and MM-w,J Sidney Farber Cancer Institute; Division of Pediatric Oncology (HTA) Sidney Farber Cancer Institute; and Departments of Medicine (DWK), Dermatology (MM"I¥,) and Pediatrics (HTA) Harvard Medical School, Boston, Massachusetts, U.S.A. Human melanomas are naturally resistant to metho resistant to the effects of MTX in vitro. The intracellular trexate (MTX). The mechanism of intrinsic drug resist uptake of MTX in these lines is comparable to other human ance has been explored in 3 melanoma cell lines not tumor cell lines. The mechanism of MTX resistance is attrib previously exposed to this agent. All 3 lines exhibited uted to elevated endogenous levels of DHFR. relative MTX resistance with ID5o values of greater than 1 fLM. Drug uptake studies were performed over an extra MATERIALS AND METHODS cellular concentration range of 0.1 to 10 ILM MTX. The Melanoma Growth Studies uptake was linear over the initial 10 min at all concen The growth characteristics of melanoma cell lines have been previ trations and subsequently reached plateau levels only at ously described [15]. Each line was established from metastatic mela the 10 ILM concentration. Lineweaver-Burke transfor noma and continues to have morphologic characteristics of melanin mations yielded apparent Km (uptake) values of 1.4 to 5 producing cells. -
Awards, Appointments, Announcements
NEWS Frederick W. Alt, Ph.D., a Howard biomedical science at the University of Awards, Hughes Medical Institute investigator at Texas Southwestern Medical Center at the Children’s Hospital of Boston, and Dallas, received the AACR Award for Appointments, the Charles A. Janeway Professor of Outstanding Achievement in Cancer Pediatrics and professor of genetics at Research. The award honors an accom- Announcements Harvard Medical School, received the plished young investigator in the field Vincent T. DeVita Jr., M.D., has 44th AACR-G.H.A. Clowes Memorial who is no more than 40 years old at the been named the Amy and Joseph Perella Award for his major discoveries involv- time the award is conferred. Wang was Professor of Medicine at Yale Univer- ing genomic stability and cancer. recognized for important discoveries sity in recognition of his contributions David Sidransky, M.D., was concerning the biochemical mecha- to cancer research and treatment. honored with the 28th AACR-Richard nisms of apoptosis. Director of Yale Cancer Center from & Hinda Rosenthal Foundation Award Paul Talalay, M.D., John Jacob Abel 1993 to 2003, DeVita currently serves for making a notable contribution to Distinguished Service Professor in the Downloaded from https://academic.oup.com/jnci/article/96/6/433/2606773 by guest on 03 October 2021 as chairman of the Yale Cancer Center improved clinical care in the field of Department of Pharmacology and Advisory Board and is a Yale University cancer. Sidransky is a professor of Molecular Sciences at the Johns Hopkins School of Medicine Professor of otolaryngology, oncology, urology, School of Medicine, was selected to Internal Medicine and Epidemiology genetics, pathology, and cellular and deliver the 9th AACR-DeWitt S. -
Dana-Farber Facts
2020FACTS Who We Are Dana-Farber Cancer Institute blends leading science and exceptional care into transformative medicine. Founded in Boston in 1947, Dana-Farber is a principal teaching affiliate of Harvard Medical School and federally designated a Comprehensive Cancer Center that develops and disseminates innovative patient therapies and scientific discoveries through- out the world. Since 1948, the Jimmy Fund has raised millions of dollars through thousands of community efforts to advance Dana-Farber’s lifesaving mission. EMPLOYEES Full-time 4,748 Part-time 483 Total 5,231 FACULTY MDs 317 PhDs 129 MD/PhDs 98 Total 544 All data in this publication is from fiscal year 2019. PATIENT CARE Dana-Farber cares for adults and children challenged with cancer, blood disorders, and related diseases. Our world-renowned specialists provide comprehensive and personalized care for each patient and support for their families. Our specialized treatment centers are staffed by teams of experts who work closely together to offer patients the latest therapies and strategies, including access to innovative clinical trials. Infusion Treatments 187,664 Outpatient MD Visits 359,519 New Patients 25,118 Unique Patients 74,084 REGISTERED NURSES Registered Nurses, Nurse Practitioners, Clinical Specialists, and Nurse Scientists 744 PATIENT SERVICES VOLUNTEERS Number of Volunteers 503 Combined Hours of Service 26,210 RESEARCH Dana-Farber remains true to its founder, Sidney Farber, MD, and his vision of a cancer center that is just as dedicated to discoveries in cancer research as it is to delivering expert, compassionate care. Through strategic investment in research, we support scientific leaders and young investigators, develop new therapies, and ensure a spirit of collaboration and innovation. -
Curing Children with Acute Lymphoblastic Leukemia
Curing Children with Acute Lymphoblastic Leukemia Hyperleukocytosis Pinkel Aur Simone Hustu Borell a Total Therapy Studies I-IV 1962-1967 • Introduce combination chemotherapy with prednisone, vincristine, cyclophosphamide, daunorubicin, cytarabine, mercaptopurine, methotrexate • Began Total Therapy with remission induction; intensification; central-nervous-system (CNS)-directed therapy; continuation (maintenance) therapy • Began cranial irradiation to prevent and treat CNS leukemia Central Nervous System Leukemia • Symptoms include: headache, mental status changes, vision changes, seizures, coma, death • Intracranial hemorrhage Facial Palsy in ALL VIIth nerve Total Therapy V 1967-1968 Total Patients 35 Complete Remission 31 Aur et al. Blood 1971; 37:272-81 Legacy of Donald Pinkel Nothing changed the fate of children with ALL (and St Jude Hospital) like Danny Thomas’s appearance on tonight show with Johnny Carson on June 26, 1972 Quote of Yaddanapudi Ravindranath Neuroimaging Abnormalities After Cranial Irradiation • Brain atrophy • Encephalomalacia • Cerebral lacunes • Dystrophic calcification • Leukoencephalopathy • Necrosis/gliosis Endocrinopathy After Cranial Irradiation Brain tumors after cranial irradiation Meningioma Malignant astrocytoma median onset: 20 years median onset: 8 years Overall Survival of Childhood ALL by Treatment Era at St. Jude 94% ± 1% XV, XVI (n=1050) 2000-2017 84% ± 2% 81% ± 2% XIIIA,XIIIB,XIV (n=465) 1991-1999 XI, XII (n=546) 1984-1991 74% ± 2% X (n=428) 1979-1983 48% ± 2% V-IX (n=825) 1967-1979 21% ± 4% I-IV -
Translating Science Into Survival
Scientific Report 2018 Scientific Report 2018 www.stjude.org/scientificreport 262 Danny Thomas Place Memphis, TN 38105 Physician Referral Service 866.278.5833 Translating Science General Information 901.595.3300 into Survival Behind the Cover The scientific image on the cover is a fluorescence image of pyramidal neurons in the auditory cortex. The brain can modify the structure and function of neuronal connections in response to sensory experiences. This ability is known as neuroplasticity. Stanislav S. Zakharenko, MD, PhD (Developmental Neurobiology), and his Faculty Editorial Board colleagues are investigating the role of neuroplasticity in the Terrence L. Geiger, MD, PhD Nickhill Bhakta, MD, MPH auditory cortex during learning and how dysfunction in that part of Michael A. Dyer, PhD the brain can cause catastrophic neurologic or psychiatric diseases. Alberto S. Pappo, MD Leslie L. Robison, PhD Carlos Rodriguez-Galindo, MD Stephen W. White, DPhil Stanislav S. Zakharenko, MD, PhD Editoral Direction Angela J. McArthur, PhD, ELS Creative Direction Jerry L. Harris Photography Peter Barta Seth Dixon Ann-Margaret Hedges Jere Parobek Prepared by Departments of Scientific Editing and Biomedical Communications St. Jude Children’s Research Hospital and ALSAC are registered trademarks. ST. JUDE INVESTIGATORS, BACKED BY EXTRAORDINARY RESOURCES AND SUPPORT TEAMS, HAVE THE FREEDOM TO FOCUS ON MAKING BIG DISCOVERIES. OUR CULTURE AND CAMPUS FOSTER THE FREE EXCHANGE OF IDEAS AMONG SCIENTISTS AND CLINICIANS TO PROMOTE CREATIVE, COLLABORATIVE SCIENCE. Privileged communication. Copyright © 2018 St. Jude Children’s Research Hospital. No part of this communication may be cited, reproduced, stored in a retrieval system, or transmitted by electronic or other means without prior written permission of the President and CEO and the appropriate investigator. -
A History of St. Judes Children's Research Hospital (.Pdf)
British Journal of Haematology, 2003, 120, 1–7 Historical Review F A HISTORY OF ST JUDE CHILDRENAPOS;S RESEARCH HOSPITAL The entertainer Danny Thomas founded St Jude Children’s Cardinal Samuel Stritch, then Catholic archbishopO of Research Hospital in Memphis, Tennessee, in 1960 and Chicago, whom Thomas had met when the former was a opened its doors in 1962 to serve children in need through bishop in Toledo. Stritch dissuaded him from building a research and medical care. Dr Donald Pinkel, the first shrine, saying there were plenty already.O They subsequently director, initiated the ÔTotal TherapyÕ series of studies of agreed that a children’s hospital for the needy was a better acute lymphoblastic leukaemia (ALL), which subsequently tribute, something like the Shriner’s hospitals in the USA, demonstrated that the disease was curable in a significant where disabled children received free care. Thomas favoured percentage of children. Pioneering studies in childhood locating the hospital in ChicagoR where he got his show cancer and high-quality basic biological research served as business start. Stritch persuaded him that Chicago already key ingredients in creating an environment of scientific had good children’s facilities and that he should find a place excellence and interdisciplinary activity. During its in greater need. StritchP suggested Memphis, Tennessee, 40 years, the institution has grown in scientific stature where he had been a parish priest and, being a practical and programmatic depth, both made possible by the skill of sort, because he was a good friend of a civic leader in its investigators, and by its physical and financial growth. -
More Than Courage
More than Courage DANA-FARBER CANCER INSTITUTE It takes more than courage to beat cancer ® What does it take to beat cancer? It takes courage, yes, and that is just the beginning. It takes world-class researchers, doctors, and technologically advanced facilities. It takes teams of dedicated professionals who offer compassionate care every day, gathering insight to inform and advance treatments for everyone. It takes focus and determination— people committed to taking the bold steps necessary to advance the cause. It also takes you. Illustrations throughout this publication represent Dana-Farber’s industry-leading science, technology, and patient care. “ I have never accepted the incurability of cancer.” — Sidney Farber, MD Founder, Dana-Farber Cancer Institute Rooted in innovation and leadership, our history remains a powerful source of motivation. The work that began in a small basement laboratory in 1947 in Boston has evolved and grown over time, and it has made Dana-Farber one of the most prestigious cancer centers in the world. Today, Dana-Farber embodies the very essence of our founder’s pioneering vision: one of leadership grounded in a commitment to research and compassion, driven to provide expert care to adults and children with cancer. It takes Experience dana-farber.org | jimmyfund.org 3 Experience Dana-Farber is a global leader in cancer A Revolutionary research and patient care. 396,000+ Vision Patient visits and infusions, annually Dana-Farber founder Sidney Farber, MD, is the father of modern chemotherapy. Founding the Institute in 1947 in Boston, Dr. Farber and his team dedicated their work to providing compassionate, state-of-the-art treatment for cancer patients, 4,500+ while researching cures of the future. -
Sidney Farber, M.D. 1903-1973 658 CANCER RESEARCH VOL. 34
Si Sidney Farber, M.D. 1903-1973 658 CANCER RESEARCH VOL. 34 Downloaded from cancerres.aacrjournals.org on October 2, 2021. © 1974 American Association for Cancer Research. OBITUARY Sidney Farber, M.D. On the evening of March 30, 1973, Dr. Sidney Farber, tion of transposition of the great vessels, a major contribu President, Director of Research, and Founder (in 1947) tion to the development of pediatrie cardiac surgery; and of The Children's Cancer Research Foundation, Inc., and focused attention on the sudden death syndrome in in S. Burt Wolbach Professor of Pathology, Emeritus, Har fants. vard Medical School, died in his office. In recent years he In 1946, Dr. Farber became Chairman of the Division of had often expressed his hope to me that he might "die in Laboratories and Research, The Children's Hospital and, harness," which he did, having spent more than 2 of the in 1947, was named Pathologist-in-Chief. Harvard Medi last hours of his life with Emil Frei, III, and me discuss cal School appointed him Professor of Pathology in 1948 ing future plans for the Foundation. American medicine and, in 1967, he became the first incumbent of the newly has lost one of its most illustrious figures, and cancer and created S. Burt Wolbach Professorship in Pathology. biomédicalresearch around the world has lost a remark In 1946, The Children's Hospital named him Chairman ably articulate and effective medical statesman and of the Staff Planning Committee; and in 1964, he was spokesman. named Chairman of the Staff, with responsiblity for the Born on September 30, 1903, in Buffalo, N. -
A Legacy of Hope for Young Leukemia Patients
For more on the Giants of Cancer Care®, visit Giants.OncLive.com Joseph V. Simone, MD An Innovator in Pediatric Cancer Care Joseph V. Simone, MD, is best known for leading the research efforts that resulted in the first curative com- bination treatment for certain pediatric patients with acute lymphoid leukemia. Under his leadership, the St. Jude Children’s Research Hospital in Memphis, Tennessee, was designated the first and only National Cancer Institute cancer center dedicated to children. He was honored in the Pediatric Oncology category with a 2017 Giants of Cancer Care® award. A Legacy of Hope for Young Leukemia Patients BY ANGELICA WELCH IN THE 1960S, PROGRAMS for treating the kids will understand. It’s tricky, though, to find cures for more children. “When you get leukemia were few and far between—especially because you can scare them, the parents are one like that, you get very, very anxious to get for children. The disease was just beginning scared—and sometimes I am scared. But I think more. That pushed us on,” he says. to be understood, and rules and regulations [having] that group—parents, doctor, our superb for taking care of both adult and pediatric nurses, and the patients involved—is something A MENTOR patients were underdeveloped and inefficient, [for which] we do not provide enough training When asked about the great strides made in as the first treatment for systemic cancers had for people,” Simone admits. the 1960s and 1970s for childhood leukemia, been developed only a decade earlier. St. Jude’s prominence grew with Simone’s Simone credits his mentor, Donald Pinkel, MD. -
The Original Documents Are Located in Box 23, Folder “4/4-5/76 - Wisconsin (3)” of the Sheila Weidenfeld Files at the Gerald R
The original documents are located in Box 23, folder “4/4-5/76 - Wisconsin (3)” of the Sheila Weidenfeld Files at the Gerald R. Ford Presidential Library. Copyright Notice The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other reproductions of copyrighted material. Gerald Ford donated to the United States of America his copyrights in all of his unpublished writings in National Archives collections. Works prepared by U.S. Government employees as part of their official duties are in the public domain. The copyrights to materials written by other individuals or organizations are presumed to remain with them. If you think any of the information displayed in the PDF is subject to a valid copyright claim, please contact the Gerald R. Ford Presidential Library. ~"":Jl"'. - •;:; r i Digitized from Box 23 of the Sheila Weidenfeld Files at the Gerald R. Ford Presidential Library . ! l ,~ - 6 - Monday, April 5, 1976 9:45 am Mrs. Ford departs Suite en route motorcade .for boarding. Motorcade assignments as on arrival except delete Mr. & Mrs. Coleman from Mrs. Ford's car. 9:50 am MOTORCADE DEPARTS Edgewater Hotel en route Truax Field. [Driving time: 20 minutes] 10:10 am MOTORCADE ARRIVES Truax Field. I"' .. Mrs. Ford boards C-9. ' f Manifest as on arrival, except add f' P. Sorum, P. Matson, & D. Kinley•. Ij l 10:20 am C-9 DEPARTS Truax Field en route General Mitchell i Field, Wlwaukee, Wisconsin. [Flying time: 25 minutes] I' [No time change.) 10:45 am C-9 ARRIVES General Mitchell Field, Milwaukee, Wisconsin (Air National Guard Ramp). -
Introduction of Donald Pinkel
Introduction of Donald Pinkel F. Lampert Organizers, colleagues, ladies and gentle then to do a proper evaluation. As to the men, and above all, dear Don, everything pathogenesis of a disease, you can read is evolution, and every new field in med about this everywhere in a book, but the icine has its beginnings and its pioneers. patient is unique!" The story of pediatric oncology is a short The second time I spoke to Don was on but fascinating one, now covering 40 the telephone, calling from Munich to years, a time span considered holy since Memphis. It was on a Tuesday, the 18th biblical times. In Germany, that is, in of May, 1971. The mother of a freshly West Germany or the Federal Republic diagnosed 6-year-old boy with acute of Germany, the real and effective pedi lymphoblastic leukemia (ALL) urged me atric oncology has an even shorter histo to call Dr. Pinkel. She had just read in ry, and its beginning is closely connected the German news magazine Der Spiegel with Dr. Pinkel's name. It is thus a great about an almost 20% 5-year-cure rate for pleasure and an honor to introduce Don ALL achieved by Dr. Pinkel's group at ald Pinkel. St. Jude's Hospital, published in the I could now present to you Don Journal of the American Medical Associ Pinkel's scientific career, or when and ation at the end of April. I had my where he was born - I think it must have doubts, but on the phone he told me been 1926, somewhere in the USA - or something about "total therapy," includ mention the many awards he received, ing radiation of the central nervous sys the last, if I remember correctly, being tem, about aggressive multiagent therapy the most prestigious and substantial up to the biological tolerance of the pa Charles Kettering prize from the General tient, and about 300 or more active pa Motors Foundation in 1986, but I will tients with ALL currently under treat confine myself to some personal memo ment at St. -
Mary Lasker Oral History Interview – JFK#1, 04/18/1966 Administrative Information
Mary Lasker Oral History Interview – JFK#1, 04/18/1966 Administrative Information Creator: Mary Lasker Interviewer: Charles T. Morrissey Date of Interview: April 18, 1966 Place of Interview: New York City, New York Length: 26 pages Biographical Note Mary Lasker was a well-known and successful health activist and philanthropist; co- founder of the Lasker Foundation; founder of the National Health Education Committee; the president of the Birth Control Federation of America; the winner of a Presidential Medal of Freedom (1969) and the Congressional Gold Medal (1989); and a personal acquaintance of John F. Kennedy [JFK] and later, after his death, a close friend of several members of JFK’s family. In this interview Lasker discusses her work lobbying for different health and medical programs such as a presidential commission on strokes; her encounters with JFK, both in the White House and socially; her friendship with Adlai E. Stevenson and his experience during the 1960 presidential campaigns; and her work on the National Cultural Center Board which she suggested be renamed as a memorial for JFK, among other issues. Access Open. Usage Restrictions According to the deed of gift signed May 30, 1990, copyright of these materials has been assigned to the United States Government. Users of these materials are advised to determine the copyright status of any document from which they wish to publish. Copyright The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other reproductions of copyrighted material. Under certain conditions specified in the law, libraries and archives are authorized to furnish a photocopy or other reproduction.