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Once a Caian... 06 Issue 4 EVENTS & REUNIONS FOR 2006-2007 ISSUE 4 MICHAELMAS 2006 GONVILLE & CAIUS COLLEGE CAMBRIDGE San Francisco Reception and Concert . Friday 15 September New York Group Reception. Monday 18 September Annual Gathering (1963, 1964 & 1965) . Saturday 23 September 1956 Golden Reunion . Monday 25 September Michaelmas Full Term begins . Tuesday 3 October Development Campaign Board Meeting . Tuesday 31 October Caius Club Dinner at Oxford & Cambridge Club. Wednesday 1 November Commemoration of Benefactors Service . Sunday 19 November Commemoration Feast . Sunday 19 November First Christmas Carol Service . Wednesday 29 November Second Christmas Carol Service. Thursday 30 November Michaelmas Full Term ends . Friday 1 December Lent Full Term begins . Tuesday 16 January 2007 Development Campaign Board Meeting . Monday 26 February Parents’ Hall . Thursday 15 March Parents’ Hall . Friday 16 March Lent Full Term ends . Friday 16 March Telephone Campaign begins. Saturday 17 March MAs’ Dinner . Friday 23 March Caius Club Dinner . Friday 30 March Annual Gathering (1973 & 1974) . Friday 13 April Easter Full Term begins . Tuesday 24 April Easter Full Term ends . Friday 15 June May Week Party for Benefactors . Saturday 16 June Caius Club Bumps Event. Saturday 16 June Caius Medical Association Meeting & Dinner . Saturday 23 June Graduation Tea . Thursday 28 June Annual Gathering (up to & including 1955). Tuesday 3 July Admissions Open Days . Thursday 5 & Friday 6 July Annual Gathering (1994 & 1995) . Saturday 22 September ...always aCaian Computers that Read Minds! Nerve Cells that Regenerate! Editor: Mick Le Moignan What Next from Caius Scientists? Editorial Board: Dr Anne Lyon, Dr Jimmy Altham, Memories of May Week 2006 Professor Wei-Yao Liang Design Consultant: Tom Challis Artwork and production: Cambridge Marketing Limited Gonville & Caius College Trinity Street Cambridge CB2 1TA United Kingdom Tel: +44 (0)1223 339676 Email: [email protected] [email protected] www.cai.cam.ac.uk/CaiRing/ ...Always a Caian 1 CK of FREE PA copy From the Director of Development in every Once a Caian… aims to celebrate Caius and Caian achievements and to share them with the wider Caian community throughout the world. I write this as the College celebrates 27% of its students gaining firsts in Tripos and is again Contents placed second in the Tompkins Table. In sport, too, the triumphs of the Caius Boat Club have just won them the coveted Clock Tower, as Martin Wade Dan White Mick LeMoignan Mick LeMoignan Mick (1962) relates in Nine Men with Ten Heads. In this issue, we focus first on the work of three Fellows. The ground-breaking research of Joe Herbert (1976) in neurology may well transform the treatment 264 available for victims of strokes, Alzheimer’s and many other diseases. Peter Robinson (1971) is venturing into a brave new world where computers will be programmed to read our moods and act accordingly. Barry Hedley (1964) clarifies the philosophy behind the changes in financial strategy that have been implemented by the College during his time as Senior Bursar. Barry has done much to ensure the success and prosperity of our College in the twenty- first century and we wish him every happiness in his retirement. We would also welcome applications from Caians as the College looks for his successor. Des LeMoignan Richard Wicksteed Richard Antony Barrington Brown Barrington Antony We also invite you: to admire firsthand the pioneering work of Linda Tucker (1985) in restoring the rare White Lion to its rightful habitat by accepting her invitation to visit the White Lions in South Africa in May 2007; to take part in 8 12 14 the highly original interactive game, Perplex City, the creation of three recent Caius graduates, using the puzzle cards they have generously enclosed; and to join the Caius Wine Club having reviewed the selection of two members of the College’s Wine Committee, Neil McKendrick (1958) and KJ Patel (1989). We look back in gratitude at Edmund Gonville, an entrepreneur of genius, and a generous man who knew also how to open the purses of his friends and patrons. He was a brilliant fundraiser and I am sure would have been delighted by the way Caians and friends of the College in the twenty-first century have responded with unprecedented loyalty and generosity to our appeals for support for the College, with the result that over 600 attended this year’s May 2 New Nerve Cells for Old – Professor Joe Herbert (1976) 4 Mind Reading Machines – Professor Peter Robinson (1971) Fellows’ Butler, Rudi Martiniani with Week Party for Benefactors. The continuing regular financial support of our retired Fellows’ Butler (1966-1995) 6 Minding Our Own Business – Barry Hedley (1964) and Caius Benefactor, John Quintana benefactors is a vital ingredient in underpinning the College’s success and is 8 First Overland – The legendary journey to Singapore with at the May Week Party. greatly appreciated. photographs by Antony Barrington Brown (1951) 12 The Lion Queen – Linda Tucker (1985) invites all Caians to visit the White Lions in South Africa in May 2007 14 The May Week Party 2006 – 600 benefactors and guests enjoy a memorable return to Caius Dr Anne Lyon (2001) 16 Mind Candy – Ralph Owen (1999) Yao Liang Yao Fellow 18 Gonville but Not Forgotten – Eleanor James (2002) 20 CaiNotes – Recent events and achievements by Caians 22 CaiMemories “A gift to Gonville & Caius College counts towards 26 The Caius Wine Club – All Caians and friends of the College are invited to join this exciting new the Cambridge 800th Anniversary Campaign” venture 28 From the Archive… …To the Present 29 CaiSport – Nine Men with Ten Heads! The Caius Boat Club wins the Clock Tower – Martin Wade (1962) Cover Photos by Des Le Moignan 2 Once a Caian... ...Always a Caian 3 neurons throughout life. factors such as temperament, family history learning, or forgetting, or selecting facts or Can we repair the damaged brain? One of the striking facts about and social adversity but also higher cortisol episodes for long-term memory requires new hippocampal neurogenesis is that it isn’t levels predispose both adolescents and adult nerve cells and, implicitly, the death of old constant. Firstly, it declines markedly with age. women to depression. Depression is about ones. There have been attempts to show this to Mick Le Moignan Mick It’s been known for some time that the twice as common in girls as boys, and we find be true, none very convincing so far. hippocampus shrinks in older people, and that that girls have about 20% more cortisol in the We really don’t know; but the fact that this is associated with declining cognitive morning than boys. We wonder if this might neurogenesis occurs opens up lots of new ideas abilities. It’s also known that both processes are account for at least some of this sex- about this part of the brain. It also suggests very variable between individuals. Increasing difference. Increased cortisol, as we have seen, that the stem cells from the hippocampus that the levels of the stress hormone cortisol would be expected to reduce neurogenesis. make new neurons might be useful in dramatically reduces neurogenesis, and this is I must be frank: there is still a long way to encouraging brain repair elsewhere. It’s an one focus of my lab. Cortisol comes from the go before establishing a convincing link extraordinary fact that there are stem cells all adrenal glands, lying, as their name suggests, Joe Herbert Joe just above the kidneys. Stress – particularly persistent or uncontrollable stress – increases cortisol remarkably. Stress – or injecting cortisol (or its equivalent in rats) – shuts off neurogenesis. Cortisol also increases with age (in some people) and preventing this, in rats, also reduces the age-related decline in neurogenesis. So, age and stress turn neurogenesis off; does anything turn it on? There are some fascinating findings. Making rats exercise (or allowing them to do so) increases the number of new cells in the hippocampus. We don’t know how this by Professor Joe Herbert (1976) happens. Jogging may be good for your brain as well as your heart. Rats that live alone don’t Cambridge Centre for Brain Repair, Department of benefit from exercise, suggesting that social Physiology, Development and Neuroscience circumstances also play a role. A couple of years ago, it was discovered The dentate gyrus under the microscope. The green cells are mature neurons, the blue ones are immature ut your finger, and in a few carry in our heads. The brain actually makes humans. In collaboration with Ian Goodyer, that Prozac (properly known as fluoxetine) and (developing) neurons (note their long processes) and the yellow are dividing stem cells making new nerve cells. days it heals. More remarkably, more neurons than it needs. Professor of Adolescent Psychiatry, we study some other anti-depressants increased if a surgeon removes part of So there’s a second process: excess neurons risk factors for clinical depression in neurogenesis. This created great excitement, between depression and neurogenesis, though over the adult brain. Only in a few areas are your liver, the rest grows to are selectively removed, a process that shapes adolescents. A bout of depression at this time which still persists: is depression associated since I work on both, I hope it materialises. these stem cells active, making new nerve cells. replace the missing bit. the adult brain and is itself influenced by all disrupts their lives, and in many cases has long- with or caused by decreased neurogenesis Now we are beginning to study how variations If we understood what was so special about CBoth are dependent on the ability of skin sorts of events (eg nutrition, stress) during standing adverse consequences for future (excess cortisol can lead to depression), or are in some of the genes associated with either the hippocampus (and those other areas that and liver cells to replicate, and thus make new intra-uterine and neonatal life.
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