Recombinant protein
Cat. No: PR0211 ( 10 μg) Source: E. coli Cat. No: PR0212 ( 25 μg) Cat. No: PR0213 ( 50 μg)
Description Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Protein Information AA Sequence: 1-207 aa (full-length). Predicted MW: 67.8 kDa Purity: >90% confirmed by SDS-Page and Coomassie blue staining. Tag: MBP tag. Buffer: 20mM Tris-HCl , 0.2M NaCl, 1 mM EDTA and 10mM Maltose, pH: 7.4. No preservatives added. Storage: Frozen / Solution. For extended storage, conserve at −80ºC. Repeated freezing and thawing is not recommended. Store working aliquots at 4ºC for up to one week. Biological activity: Not tested.
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Canvax Biotech, S.L. C/ Astrónoma Cecilia Payne, Edificio Orión. 14014 Córdoba, Spain. : +34 957 348 066 : +34 957 346 217 : [email protected]
Gene Information Synonyms: TIMP1 protein; TIMP-1; Erythroid potentiating activity; EPA; Tissue inhibitor of metalloproteinases; Fibroblast collagenase inhibitor; Collagenase inhibitor, human; HCI; Tissue inhibitor of metalloproteinase 1; TIMP1; CLGI; TIMP. Official Symbol: TIMP1. Specie: Homo sapiens. GenBank accession number: NM_003254.1 NCBI Protein RefSeq: NP_003245.1 Protein Family: Chemokine.
Applications ELISA, WB, Antibody Production and Protein array.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Canvax Biotech, S.L. C/ Astrónoma Cecilia Payne, Edificio Orión. 14014 Córdoba, Spain. : +34 957 348 066 : +34 957 346 217 : [email protected]