Electrode Position and the Clinical Outcome After Bilateral Subthalamic Nucleus Stimulation
ORIGINAL ARTICLE Neuroscience http://dx.doi.org/10.3346/jkms.2011.26.10.1344 • J Korean Med Sci 2011; 26: 1344-1355 Electrode Position and the Clinical Outcome after Bilateral Subthalamic Nucleus Stimulation Sun Ha Paek1,2,5,6,7, Jee-Young Lee1,3, We compared the surgical outcome with electrode positions after bilateral subthalamic Han-Joon Kim1,3, Daehee Kang4, nucleus (STN) stimulation surgery for Parkinson’s disease. Fifty-seven patients treated with Yong Hoon Lim1, Mi Ryoung Kim1, bilateral STN stimulations were included in this study. Electrode positions were determined Cheolyoung Kim8, Beom Seok Jeon1,3,5 in the fused images of preoperative MRI and postoperative CT taken at six months after 1,2 and Dong Gyu Kim surgery. The patients were divided into three groups: group I, both electrodes in the STN; group II, only one electrode in the STN; group III, neither electrode in the STN. Unified 1Movement Disorder Center and Clinical Research Institute, Seoul National University Hospital, Seoul; Parkinson’s Disease Rating Scale (UPDRS), Hoehn and Yahr stage, and activities of daily Departments of 2Neurosurgery and 3Neurology, living scores significantly improved at 6 and 12 months after STN stimulation in both group Seoul National University Hospital, Seoul; I and II. The off-time UPDRS III speech subscore significantly improved (1.6 ± 0.7 at 4 Department of Preventive Medicine, Seoul National baseline vs 1.3 ± 0.8 at 6 and 12 months, P < 0.01) with least L-dopa equivalent daily University College of Medicine, Seoul; 5Neuroscience Research Institute, 6Ischemia dose (LEDD) (844.6 ± 364.1 mg/day at baseline; 279.4 ± 274.6 mg/day at 6 months; and Hypoxia Disease Institute and 7Cancer Research 276.0 ± 301.6 mg/day at 12 months, P < 0.001) at 6 and 12 months after STN deep brain Institute, Seoul National University College of stimulation (DBS) in the group I.
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