Anti-NAE1 (Full Length) Polyclonal Antibody (DPAB- DC3678) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-NAE1 (full length) polyclonal antibody (DPAB- DC3678) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Immunogen APPBP1 (AAH00480, 1 a.a. ~ 534 a.a) full-length recombinant protein with GST tag. The sequence is MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQV SGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVAT QLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHF QSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPED EENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTI PDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVR CRSLAEEY

Source/Host Mouse

Species Reactivity Human

Conjugate Unconjugated

Applications WB (Recombinant protein), ELISA,

Size 50 μl

Buffer 50 % glycerol

Preservative None

Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol NAE1

Synonyms NAE1; NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1; NEDD8- activating enzyme E1 regulatory subunit; APP-BP1; protooncogene protein 1; proto-oncogene protein 1; amyloid protein-binding protein 1; NEDD8-activating enzyme E1 subunit; amyloid beta precursor protein-binding protein 1, 59kD; amyloid beta precursor protein binding protein 1, 59kDa; amyloid beta precursor protein-binding protein 1, 59 kDa;

Entrez Gene ID 8883

Protein Refseq NP_001018169

UniProt ID Q13564

Chromosome Location 16q22

Pathway Alzheimers disease; Alzheimers Disease.

Function contributes_to NEDD8 activating enzyme activity; protein binding; protein heterodimerization activity; ubiquitin protein ligase binding

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]