Curriculum Vitae Ana Navas-Acien, MD, MPH, PhD 3260 Henry Hudson Parkway, Apt. 9-A Bronx, NY 10463 [email protected]

PERSONAL DATA Date of preparation: June 12, 2019 Name Ana Navas Acien Date of Birth: April 12, 1972 Birthplace: Almeria, Citizenship Spain, US Resident

Academic Appointments / Work Experience

06/2016 - present Department of Environmental Health Sciences New York, NY Mailman School of Public Health, Columbia University Professor

01/2018 - present Earth Institute New York, NY Columbia University Associate Member

01/2018 - present Columbia University Superfund Research Program New York, NY Director

01/2012 - 05/2016 Department of Environmental Health Sciences Baltimore, MD Johns Hopkins University Bloomberg School of Public Health Associate Professor

11/2005 - 12/2011 Department of Environmental Health Sciences Baltimore, MD Johns Hopkins University Bloomberg School of Public Health Assistant Professor

09/2014 - 05/2016 Exposure Science and Environmental Epidemiology PhD Track Baltimore, MD Johns Hopkins University Bloomberg School of Public Health Director

01/2011 - 05/2016 Department of Oncology Baltimore, MD Johns Hopkins University School of Medicine Joint Appointment

06/2007 - 05/2016 Department of Epidemiology Baltimore, MD Johns Hopkins University Bloomberg School of Public Health Joint Appointment

06/2007 - 05/2016 Welch Center for Prevention Epidemiology and Clinical Research Baltimore, MD Johns Hopkins Medical Institutions Core Faculty

01/2006 - 2017 Institute for Global Tobacco Control Johns Hopkins University Bloomberg School of Public Health Baltimore, MD Affiliated Faculty

1 Training

05/1997- 06/2001 Department of Preventive Medicine and Public Health Madrid, Spain University Hospital La Paz Rotations in Epidemiological Surveillance, Clinical Research, Microbiology, Occupational Health, and Quality Assurance and external rotations (see below) Medical Resident

09/2000-10/2001 Cancer and Environmental Epidemiology Area Madrid, Spain National Center for Epidemiology, Carlos III Institute of Health Research Fellow

09/1999 - 08/2000 Division of Disease Prevention and Control Washington DC, US Pan American Health Organization (PAHO/WHO) Consultant

06/1996 - 05/1997 Cancer Registry of Granada Granada, Spain School of Public Health of Andalusia Research Assistant

10/1993 – 05/1996 Department of Biochemistry and Molecular Biology Granada, Spain School of Medicine, University of Granada Intern Student (lab assistant) Education

11/2001 - 05/2005 Johns Hopkins University Bloomberg School of Public Health Baltimore, MD PhD Major: Cardiovascular Epidemiology Thesis title: A prospective study of low arsenic exposure, diabetes and fatal myocardial infarction in Washington County, Maryland. Advisor: Eliseo Guallar

05/1997 - 05/1998 National School of Health Madrid, Spain MPH (Public Health)

10/1990 – 06/1996 School of Medicine, University of Granada Granada, Spain Medicine and Surgery (MD) Honors

2019-2023 Member of the Kidney, Nutrition, Obesity and Diabetes Study Section (KNOD).

2019 The 15th International Conference on the Biogeochemistry of Trace Elements, Nanjing, China. Plenary Speaker.

2019 Dean’s Excellence in Mentoring Award, Mailman School of Public Health, Columbia University

2017 Provost Leadership Fellow, Columbia University

2017 NIEHS Paper of the month (The effect of the Environmental Protection Agency maximum containment level on arsenic exposure in the USA from 2003 to 2014: an analysis of the National Health and Nutrition Examination Survey (NHANES). The Lancet Public Health. 2017)

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2017 State of the Art Speaker at the Thomas L Petty Aspen Lung Conference. Roger Mitchell lecture. Aspen, Colorado June 2017

2016 Invited as a plenary speaker to the 6th International Congress on Arsenic in the Environment, Stockholm, Sweden June 2016

2016 Member of the Scientific Committee, the 6th International Congress on Arsenic in the Environment, Stockholm, Sweden June 2016

2015 Recognized as Outstanding Teaching Faculty by the Johns Hopkins University Bloomberg School of Public Health for the course 340.680.11 “Environmental and Occupational Epidemiology”

2014 Advising, Mentoring & Teaching Recognition Award (AMTRA), Johns Hopkins University Bloomberg School of Public Health

2014 Member of the Scientific Committee, 26th Environmental Health Conference, International Society Environmental Epidemiology (ISEE), Chair of the Metal Section

2013 Invited as founding Editor-in-Chief of Current Environmental Health Reports, published by Springer (indexed by PubMed in 2015).

2013 Member of the Scientific Committee, 25th Environmental Health Conference, International Society Environmental Epidemiology (ISEE)

2012 Member of the Scientific Committee, 24th Meeting of the International Society Environmental Epidemiology (ISEE)

2012 Member of the Scientific Committee, 2012 Society for Research on Nicotine and Tobacco

2011 Member of the Scientific Committee, 23rd Meeting of the International Society Environmental Epidemiology (ISEE)

2010 Delta Omega Honor Society, Alpha Chapter, Johns Hopkins Bloomberg School of Public Health

2009 Advising, Mentoring & Teaching Recognition Award (AMTRA), Johns Hopkins Bloomberg School of Public Health

2007, 2008 Nominated for the Advising, Mentoring & Teaching Recognition Award (AMTRA), Johns Hopkins Bloomberg School of Public Health

2005 Phi Beta Kappa, Johns Hopkins University

2004-2005 Center for Excellence in Environmental Public Health Tracking Research Fellowship (CDC / Johns Hopkins Bloomberg School of Public Health)

2002-2004 Fulbright Scholar, sponsored by Spain’s Ministry of Health and Consumer Affairs

2001-2002 Robert Dyar Memorial Award Fund, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public health

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2000 - Spanish medical civil servant (leave of absence) – Inspector Medico (en excedencia)

1997 Exam “M.I.R” (medico interno residente), the official exam for selection of medical residency in Spain, ranked 1st percentile.

1996 Medical degree with 23 grades A with honor (matricula de honor) over 30, University of Granada, Spain

1994-1996 Initiation to Research Award, Department of Biochemistry and Molecular Biology, University of Granada granted by the Ministry of Science and Education, Spain.

Summer 1994 Exchange Fellowship, International Federation of Medical Student Association, Department of Internal Medicine, Hospital Geral Santo Antonio. Oporto,

1992-1993 Fellowship awards of the International University Menendez Pelayo (UIMP), Santander, Spain: Summer courses.

Professional Organizations, Societies and Service

Society Membership:

International Society Environmental Epidemiology (ISEE) Council on Epidemiology and Prevention, American Heart Association (AHA) Spanish Society of Epidemiology (SEE)

Panels and committees:

2018 - National Academies of Sciences, Engineering, and Medicine’s Workshop Committee to Support Development of EPA’s IRIS Toxicological Reviews, committee member

2018 - National Academies of Sciences, Engineering, and Medicine’s Ad-hoc Committee Evaluation of the Protocol for the IRIS Toxicological Review of Inorganic Arsenic

2018 - American Diabetes Association. Social Determinants of Health Scientific Review Panel, panel member.

2017 - National Academy of Medicine Standing Committee on Health Effects of Air Pollution Exposure for State Department Employees and their Families

2017 - 2018 National Academy of Sciences, Engineering and Medicine Committee Review of the Health Effects of Electronic Nicotine Delivery Systems (ENDS)

2015 National Research Council Committee Guidance for and Review of EPA’s IRIS Toxicological Assessment of Inorganic Arsenic, committee member

2015 Developing Study Quality Methods for EPA's IRIS Program. EPA working group on phthalates and diabetes outcomes

2015 National Research Council Committee Exposome Worskshop, committee member

2012-2013 National Research Council Committee Guidance for and Review of EPA’s IRIS Toxicological Assessment of Inorganic Arsenic, committee member

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2011-2016 National Academy of Sciences Standing Committee on Emerging Science for Environmental Health Decisions, committee member

2011-2012 National Research Council Committee on Science for EPA’s Future, committee member

2008-2012 Global burden of disease caused by lead – WHO Expert panel, panel member

2011 National Toxicology Program Monograph on the Health Effects of Low-Level Lead, Technical advisor

2011 National Toxicology Program Workshop: Role of Environmental Chemicals in the Development of Diabetes and Obesity. Raleigh, North Carolina, January 10-13, 2011 (Public meeting January, 11-13, 2011), panel member

Advisory Committees: 2010 – 2016 Steering Committee of the multi-ethnic study of atherosclerosis and air pollution (MESA Air) 2014 – Steering Committee of the Strong Heart Study

2015 – Advisory Board, TackSHS project (Tackling secondhand tobacco smoke and e-cigarette emissions: exposure assessment, novel interventions, impact on lung diseases and economic burden in diverse European populations), funded by the European Union

2016 Advisory Board, American Academy of Pediatrics Julius B. Richmond Flight Attendant Medical Research Institute (FAMRI) Center of Excellence

2016 – Advisory Board, Center for Native American Environmental Health Equity Research, University of New , funded by NIEHS

2018 – Environmental Health Perspectives News Advisory Committee

2018 – External Scientific Committee, Instituto de Investigacion Biosanitaria Granada (ibs.Granada) (Institute of Biohealth Research).

2019 – Centro de Investigacion Biomedica en Red (Epidemiologia y Salud Publica) (CIBERESP), Instituto Salud Carlos III.

Editorial Activities:

2014 – Current Environmental Health Reports, Editor in Chief 2013 – 2016 Environmental Research, Editorial Board Member 2016 – Environmental Health Perspectives, Associate Editor 2016 – Environmental Research, Associate Editor 2017 – Annals of the American Thoracic Society, Editorial Board Member

Peer Review Activities:

Am Heart J (Feb 14, Oct 15, May 17); Am J Epidemiol (Dec 03, Mar 04, Jul 05, Feb 08, Aug 09, Nov 09, June 10, Sep 11, Oct 11, Mar 12, Jun 12, Nov 14, Feb 15, Jun 15, Nov 16, Feb 17); Am J Kid

5 Disease (Aug 09, Dec 16); Am J Prev Med (Aug 04, Jul 05); Am J Public Health (Apr 09, Aug 10, Oct 12, Jan 13, Oct 14); Annals Occup Hygiene (Sep 09); Applied Geochemistry (Jan 08); Arch Toxicol (Jun 15); Atmospheric Environment (Jun 06); Atherosclerosis (Nov 07, Nov 08); Biol Trace Element Research (Mar 10); Biometals (Dec 09); BMC Public Health (Jan 10, Aug 11, Aug 12, Sep 14); BMC Nephrol (Feb 14); BMJ (Dec 11); Bulletin WHO (Nov 06, Oct 07, Sep 09, Jan 10); Cancer Epidemiol Biomarkers Preven (Sep 13, Jan 14, May 15); Circulation (Feb 09, Jan 10, Dec 11, Mar 19); Diab Care (Dec 11, May 12, Sep 12, Nov 12, Oct 13); Diab Res Clin Pract (Dec 11); Environ Health (Jun 11, Dec 11, Nov 14); Environ Health Perspect (Aug 05, Jan 06, May 06, Nov 06, Jan 08, Jan 09, Mar 09, Aug 09, Jan 10, Feb 10, April 10, Jul 10, Aug 10, Sep 10, Feb 11, Jun 11; Dec 11, Jan 12, Mar 12, Aug 12, Nov 12, Mar 13, Jun 13, Nov 13, Dec 13, Dec 13, Jan 14, Jun 14, Jul 14, Sep 14, Feb 15, May 15, Nov 15, Jul 16, Aug 16); Environ Intern (Feb 17); Environ Research (Nov 04, Jan 05, Mar 05, May 05, Oct 05, Feb 06, Aug 06, Nov 06, Jan 07, Feb 07, Dec 07, Mar 08, Jul 08, Feb 09, May 09, Sep 09, Oct 09, Jan 11, Jun 11, Dec 11, Feb 12, May 12, Aug 12; Oct 12, May 13, Nov 13, Jan 14, Apr 14, Aug 14, Jun 15, Oct 15, Jun 19); Environ Sci Technol (May 13); Epidemiology (Jun 04, July 08, Aug 08, Sep 08, Feb 09, Oct 09, May 11, Oct 11, Aug 12, Jun 13); European Heart J (Oct 08, Jan 09); Food Nutrition Bulletin (Oct 07); Gaceta Sanitaria (Apr 05); Health Policy Planning (Aug 12); JAHA (Oct 16); JAMA (Jan 08, Oct 08, Nov 08, Feb 12, Dec 13, Jan 18); J Environ Monitoring (Mar 10); J Epidemiol Community Health (Jul 16); J Exp Sci Env Epidemiol (Nov 10, Dec 15); J Human Ecological Risk Assessment (Dec 08); J Occup Environ Med (Oct 08, Feb 09, Feb 11); J Public Health Policy (Feb 17); J Translation Med (Oct 16); Int J Epidemiol (Sep 07, May 16); Int J Environ Res Public Health (Jan 09, Feb 09); Int J Hygiene Environ Health (Dec 09, Jul 11, Oct 11); IUBMB Life (Oct 05); Lancet Public Health (Dec 17); Med Science Monitor (Sep 06); New Engl J Med (May 10, Sep 10, May 13); Nephrol Dialysis Transplant (Feb 08, Sept 08); Nicotine Tobacco Research (Mar 10, Mar 12, Aug 12, Aug 14, Nov 14); Nutrition Metab Cardiovasc Diseases (Oct 09); Pediatrics (Mar 13); Pan Am J Public Health (Dec 06); Plos Genet (Aug 14), Plos One (Feb 13, Sep 14, Feb 15, May 17), Sci Total Environ (Oct 10, Mar 12); T Royal Society Tropical Med Hyg (Sep 07); Tobacco Control (Jan 11, Oct 11, Mar 12, Aug 12, Nov 13, May 15, Feb 16, April 17, May 17); Toxicol Sciences (Apr 08, Sep 08, Jan 12, Jul 15, Mar 16).

Scientific meetings (review of proceedings) International Society Environmental Epidemiology (ISEE 2009, 2012, 2013, 2014, 2015) World Conference on Tobacco or Health (WCTOH 2012) Society for Nicotine and Tobacco Research (SNTR 2012)

Review of Proposals

NIH Panels

07/2019-06/2023 Kidney, Nutrition, Obesity and Diabetes Study Section (KNOD). Member.

2019/05 ZES1 JAB-D (R1) 1 Evaluation of the R01 Victer (TT) Environmental Research Grant Applications. Reviewer.

2019/10 ZES1 LKB-K (R) 2 Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts. Reviewer.

2019/05 ZES1 ARL-K (U) 2 Human Health Exposure Analysis Resource (HHEAR): Data Repository Center. Reviewer.

6 Cancer, Heart, and Sleep Epidemiology Panel A Study Section (CHSA) study section. June 2018. Reviewer

Kidney, Nutrition, Obesity and Diabetes (KNOD) study section, February 2018. Reviewer.

TCORS, Tobacco Centers of Regulatory Science for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (U54). RFA-OD-17-006. Reviewer.

ZRG-1 HDM V 51 Special Emphasis Panel: Health Promotion and Disease Prevention Among Native American Populations, Oct 2017. Reviewer.

PAR 13-109: Mechanistic Insights from Birth Cohorts (R01), NIH, June 2015. Reviewer.

RFA-DK-14-006 NIDDK U.S.-India Bilateral Collaborative Research Partnerships (CRP) on Diabetes Research (R21) Panel ZDK1 GRB-S (M3), January 2015. Reviewer.

PAR-11-306 NIDDK Central Repositories Non-renewable Sample Access (X01) Special Emphasis Panel ZDK1-GRB-S (O1), May 2014. Reviewer.

PAR11-346: Interventions for Health Promotion and Disease Prevention in Native American Populations, December 2013. Reviewer.

Kidney, Nutrition, Obesity and Diabetes (KNOD) study section, June 2013. Reviewer.

Thrasher Research Fund (Children’s medical research), August 2010. Reviewer.

NIEHS ViCTER Panel Review (PAR-10-030), North Carolina, May 2010. Reviewer.

Other

University of California Office of the President Tobacco-Related Disease Research Program (TRDRP). Thirdhand Smoke Consortium. Apr 17, 2018. Chair of the Study Section.

University of California Office of the President Tobacco-Related Disease Research Program (TRDRP). Environmental Exposure and Toxicology. Apr 16, 2018. Chair of the Study Section.

University of California Office of the President Tobacco-Related Disease Research Program (TRDRP). Environmental Exposure and Toxicology. Dec 19, 2017. Chair of the Study Section.

Maryland Cigarette Restitution Fund, Pilot Project Applications, 2015. Reviewer.

Harvard-NIEHS Center for Environmental Health, Pilot Project Grants 2014, 2015, 2017. Reviewer.

FWO (Fonds Wetenschappelijk Onderzoek) Vlaanderen, Belgium, April 2010. Reviewer.

AAAS 2010-2011 Science and Technology Policy Fellowships, February 2010. Reviewer.

CDC Grants for Public Health Dissertation (Panel K)- PAR07-231. June 2009. Reviewer.

Flight Attendant Medical Research Institute. External peer review for the 2008 Young Clinical Scientist Award (YCSA) Renewal Application Form. April 2008. Reviewer.

7 Nacional Academy of Sciences. US Academy for International Development. Middle East Regional Cooperation (MERC) Program. Washington DC, October 2006. Reviewer.

Pilot Mentoring Program for the FCTC International Small Grants Research Competition, IDRC : February 2005, July 2006. Reviewer.

Agencia Nacional de Evaluación y Prospectiva. Spanish Ministry of Science and Technology (ANEP), Spain: May 2005, January 2006. Reviewer.

Spanish Medical Research Fund (Fondo de Investigación Sanitaria (FIS)). Instituto de Salud Carlos III. Spanish Ministry of Health: May 2006, February 2007. Reviewer.

Fondo para la Investigación y Prevención del SIDA en España. Spanish Ministry of Health (FIPSE): July 2005. Reviewer.

Universidad del Norte-Barranquilla Grant Program, Colombia, March 2005. Reviewer.

Review of Reports and Other Service 2017 External reviewer for the National Academies of Sciences Engineering and Medicine’s Proceedings of a workshop – in brief: Advances in Causal Understanding for Human Health Risk-based Decision Making. Reviewer 2014 External reviewer for the National Research Council draft report “Review of EPA’s Integrated Risk Information System (IRIS) process”. Reviewer 2013 Consultant to the Office of Medical Services of the Peace Corps 2011 External reviewer for the Institute of Medicine draft report on “Scientific Standards for Studies of Modified Risk Tobacco Products.” Reviewer 2007 US Environmental Protection Agency. External peer review of the draft EPA document entitled: Estimating Perchlorate Intakes from Food and Drinking Water Using the NHANES Biomonitoring Data and UCMR 1 Occurrence Data. October 2007. Reviewer.

Testimony:

Expert Witness to the Senate Judicial Proceedings Committee, Maryland General Assembly: Senate Bill 559 - Vehicle Laws - Prohibition Against Smoking in Vehicle Containing Young Child. February 21st, 2012.

Expert Witness to the Baltimore City Council: Bill for a Clean Indoor Air in All Occupational Settings including Bars and Restaurants. Baltimore City Hall, October 25th 2006.

Expert Witness to the Baltimore City Council: Bill for a Clean Indoor Air in All Occupational Settings including Bars and Restaurants. Baltimore City Hall, February 9th 2005.

Departmental and University Committees

Environmental Health Sciences, Columbia University

2017 - EHS Chair’s circle

2017 - Curriculum Committee

8 2018 - Doctoral students preliminary oral exam committee

2017 - Master students admissions committee

Mailmam School of Public Health, Columbia University

2018 - 2019 Robert N Bultler Columbia Aging Center, Director Search committee (co-Chair)

Columbia University Earth Institute

2018 - Earth Institute, Post-doctoral Selection Committee

2018 - Earth Institute, Faculty Development and Diversity Committee

2018 - Earth Institute, Communications Task Force

2019 - Interdisciplinary Sustainability Research Group

Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health

2006 – 07 Enrichment and seminars committee, member

2007 – 08 Strategic planning for educational programs ad hoc committee, member

2007 – 16 Research committee (previously named “Enrichment and seminars committee), member

2010 – 16 MHS Environmental Health Sciences internal advisory committee, member

2010 Toxicology Faculty Search ad hoc committee, member

2010 – 11 Environmental epidemiology faculty search ad hoc committee, co-chair

2012 Strategic planning ad hoc committee, member

2013 Review of business office ad hoc committee, member

2014 Center for Livable Future director search committee, member

2014 Environmental Disease: Molecular Mechanisms and Pathophysiology faculty search, ad hoc committee

2014 – 16 Exposure Science and Environmental Epidemiology PhD Track, Co-Director

2014 – 16 Educational Program Committee, member

2014 – 16 Executive committee, member

2014 Environmental Disease: Molecular Mechanisms and Pathophysiology faculty search ad hoc committee, member

2015 Environmental Epidemiology faculty search ad hoc committee, member

2015 - 16 Summer Institute Internal Advisory Committee

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Welch Center for Prevention, Epidemiology and Clinical Research

2008 – 2011 Publication committee

Institute for Global Tobacco Control

2012 Global Tobacco Control Alumni Awards for Excellence, Selection Committee

Johns Hopkins Bloomberg School of Public Health School

2006 – 2016 Brown Scholars Advisory Committee. Johns Hopkins Bloomberg School of Public Health

2009 – 2011 Faculty senate, member

2012 – 2014 Implementation Science Committee

2012 Ad-hoc Appointments and Promotions Committee

2014 - 2015 Review committee for the Department of Biostatistics

Fellowship and Grant Support

Active grants

1. Title of grant: “Low-level Arsenic Exposure and Cardiovascular Disease in Multi-Ethnic Adults (MESA As)” Dates: 8/1/2018-5/31/2023 Sponsoring agency: NIEHS R01ES028758 Principal investigator: Ana Navas-Acien Funding level: $540,122 To evaluate cardiovascular effects of low-level arsenic exposure in US multi-racial/ethnic adults as well as relevant moderators and mediators of those associations. Role: PI.

2. Title of grant: “Participatory Interventions to Reduce Arsenic in American Indian Communities Dates: 7/1/2015-3/31/2020 Sponsoring agency: NIEHS 1R01ES025135 Principal investigator: Christine M. George / Ana Navas-Acien Funding level: $501,038 To develop, evaluate and disseminate a participatory-based intervention to remediate arsenic exposure through drinking water in American-Indian communities. Role: Principal investigator

3. Title of grant: “Arsenic, Epigenetics and Cardiovascular Disease in American Indians” Dates: 6/15/2015-3/31/2019 Sponsoring agency: NIEHS 1R01ES025216 Principal investigator: Ana Navas-Acien/ M Daniele Fallin Funding level: $499,999 To investigate if DNA epigenetic modifications mediate arsenic related cardiovascular disease in American Indian participants in the Strong Heart Study and to evaluate the interplay between genetic variability and arsenic-related epigenetic modifications in cardiovascular disease. Role: Principal investigator

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4. Title of grant: “Harmful constituents and respiratory effects of waterpipe smoke” Dates: 7/2/2016-6/30/2021 Sponsoring agency: NHLBI 1R01HL134149 Principal investigators: Shyam Biswal / Thomas Hartung / Ana Navas-Acien Funding level: $300,000 This study will provide information on exposure science, tobacco related biomarkers, in vitro and in vitro toxicology from animal, in vitro and epidemiologic studies to inform on the harmful constituents of waterpipe smoke. Role: PI

5. Title of grant: “Metals in the Trial to Assess Chelation Therapy 2 (TACT2M)” Dates: 9/1/2016-08/31/2021 Sponsoring agency: R01AT009273 Principal investigator: Gervasio Lamas Funding level: $2M The main objectives of the Metals in the Trial to Assess Chelation Therapy 2 (TACT2M) are to evaluate whether long-term edetate disodium (EDTA)-based chelation infusions can significantly reduce body lead and cadmium levels and to determine whether this effect explains the reduction in major cardiovascular events caused by EDTA chelation therapy. Role: Scientific PI and PI of subcontract

6. Title of grant: “Arsenic and immune response to influenza vaccination in pregnant women and newborns” Dates: 4/1/2017-3/31/2022 Sponsoring agency: NIEHS 1R01ES026973 Principal investigator: Christopher Heaney / Alain Labrique Funding level: $500,000 Pregnancy cohort to investigate how maternal arsenic exposure and one-carbon metabolism micronutrient deficiencies alter maternal and newborn influenza antibody titer and avidity, respiratory morbidity, and markers of systemic immune function following maternal influenza vaccination. Role: Co-I

7. Title of grant: “Columbia University Superfund Research Program (CU SRP) Health Effects of Arsenic” Dates: 4/1/2017-9/30/2019 Sponsoring agency: NIEHS 2 P42 ES010349 Principal investigator: Ana Navas-Acien Funding level: $962,023 This center is composed by 2 biomedical projects, 2 geoscience projects, and 6 support cores including Research Translation, Community Engagement and Training Cores. The center focuses on the investigation of the characterization and prevention of the health effects of chronic arsenic exposure. Role: Program Director, co-PI of Project 1, co-I of Projects 2 and 4, co-director of the Training Core.

8. Title of grant: “Principal Component Pursuit to Assess Exposure to Environmental Mixtures in Epidemiologic Studies” Dates: 1/1/2018-12/31/2021 Sponsoring agency: NIEHS R01ES028805 Principal investigator: Marianthi-Anne Kioumourzoglou Funding level: $400,000

11 This study will develop a novel method to study environmental mixtures in epidemiologic studies and it will be applied to existing population-based cohorts including the Strong Heart Study. Role: co-PI.

9. Title of grant: “Undergraduate Research Program to Promote Diversity in EHS” Dates: 4/1/2018 – 3/31/2020 Sponsoring agency: 5R25 ES025505 Principal investigator: Ana Navas-Acien Funding levels: $101,903 The mission of this program is to increase the knowledge and interest of underrepresented minority undergraduates in environmental health sciences and to provide a pipeline of qualified candidates for graduate programs. Role: PI.

10. Title of grant: “Initiative to Maximize Student Development at Columbia's Mailman School of Public Health” Dates: 4/1/2018 – 3/31/2020 Sponsoring agency: 5R25 GM062454 Principal investigator: Goldsmith/Martins/Navas-Acien/Wingood Funding levels: $467,936 The Initiative for Maximizing Student Development (IMSD) at Columbia's Mailman School of Public Health provides an education project for under-represented students that includes various strategies to address barriers in pursuing and successfully completing graduate-level education. Role: mPI.

11. Title of grant: “Maternal Exposure to Inorganic Arsenic in Drinking Water and Adverse Birth Outcomes in Rural Colorado” Dates: 03/01/2018-2/28/2020 Principal investigator: Katherine James Sponsoring agency: NIH R21ES028416 Funding level: $11,570 (subcontract) This ecologic study will assess the association between maternal exposure to inorganic arsenic in drinking water and adverse birth outcomes in rural Colorado. Role: Co-I (PI of subcontract).

12. Title of grant: “Exposure to Metals from E-Cigarettes (EMIT) Study” Dates: 09/20/2018 – 06/30/2021 Sponsoring agency: NIEHS R01ES030025 Principal Investigator: Ana Rule Funding level: $ $47,406 (subcontract). The goal of this project is to compare metal exposure and biomarker levels across diverse e- cigarette products including open/refillable and closed/non-refillable systems. Role: Co-I (PI of subcontract)

13. Title of grant: Tracking Metals From E-cigarettes: From the Coil into Lung Tissue Dates: 9/20/2018 – 6/30/2020 Sponsoring agency: NIEHS R21ES029777 Principal Investigator: Markus Hilpert Funding level: $150,000 The goals of this project are (1) to quantify metal transfer from E-cigarette hardware into EC aerosol while also identifying which components of the hardware leach metals into the aerosol, and (2) to examine the effects of E-cigarette use and hardware on metal uptake in a mouse model of exposure.

12 Role: Co-I

Pending grants

13. Title of grant: “Study of Arsenic and Cardiometabolic Outcomes in SOL (SACoS)” Dates:4/01/2020-3/31/2024 Sponsoring agency: NIH Funding level: $92,842 (subcontract) Case-cohort study to assess the effects of arsenic exposure and metabolism on the development of diabetes and cardiovascular disease in an urban, minority population leveraging HCHS/SOL and MESA-Hispanic. Role: Co-I (PI of subcontract)

14. Title of grant: “E-Cigarette Use, Toxic Metal Exposure, and Cardiovascular Effects in Diverse Adults” Dates: 9/1/2017-8/31/2021 Sponsoring agency: R01ES029967 Principal investigator: Ana Navas-Acien Funding level: $499,000 To evaluate the association of e-cigarette use in subclinical cardiovascular disease (inflammation and oxidative stress, vascular dynamics, and coronary calcification), the association of e-cigarette use with metal exposure, and the potential role of these metals to explain, at least in part, the cardiovascular effects of e-cigarettes. Role: Principal investigator.

15. Title of grant: “Cadmium, lead and subclinical atherosclerosis in multi-ethnic adults” Dates: resubmission pending Sponsoring agency: NIH 1R01ES018913 Principal investigator: Ana Navas-Acien Funding level: US $499,000 Cross-sectional study to investigate the association of cadmium and lead exposures, as measured in blood, with markers of subclinical atherosclerosis in men and women participating in the Multi- ethnic study of atherosclerosis (MESA). Role: Principal investigator. [Resubmission planned]

Past grants

1. Title of grant: “Arsenic exposure, genetic determinants and diabetes risk in a family study” Dates: 07/01/2012-09/30/2017 Sponsoring agency: NIEHS R01ES021367 Principal investigator: Ana Navas-Acien / Linda Kao (replaced by Dhananjay Vaidya) Funding level: US $688,401 Prospective family study to evaluate the relationship of arsenic exposure and metabolism, and gene-environment interactions with diabetes, the metabolic syndrome and insulin resistance in the Strong Heart Family Study. Role: Principal investigator Renewal submitted July 5, 2017.

2. Title of grant: “Secondhand smoke evaluation of the legislation in Turkey” Dates:2/11/2017-6/30/2017 Sponsoring agency: Bloomberg Worldwide Stop Smoking Initiative Funding level: $32,954. To assess exposure to tobacco smoke and implementation of smoke-free legislation in Turkey.

13 Role: PI

3. Title of grant: “Cardiovascular Effects of Environmental Cadmium Exposure” Dates: 5/20/2013 – 4/30/2015 [No cost extension] Sponsoring agency: NIEHS R21ES021831 Principal Investigator: Katherine James Prospective cohort study to evaluate the association of cadmium exposure with incident cardiovascular disease in Hispanic and White populations from Rural Colorado: San Luis Valley Study Role: Co-I (PI of subcontract)

4. Supplement to “Arsenic exposure, cardiovascular disease and diabetes in Native Americans” Dates: 09/05/2008-08/31/2014 Sponsoring agency: NHLBI R01HL090863 Principal investigator: Ana Navas-Acien Funding level: US $499,000 Main grant objective: to investigate the association of total urine arsenic and arsenic species concentrations with cardiovascular disease and diabetes risk in Native Americans who participated in the Strong Heart Study. Role: Principal investigator

5. Title of grant: “MESA (multi-ethnic study of atherosclerosis) air pollution study” Dates: 11/01/09-06/30/14 Sponsoring agency: EPA (RD-83169701-3) Principal investigator: Joel Kaufman (U. of Washington) Funding level: US $ 163,424 Multi-center population-based prospective study of the association of air pollution with cardiovascular risk and subclinical markers of atherosclerosis in a multi-ethnic US adult population. Role: PI of subaward (480716)

6. Title of grant: “Lead, cadmium, arsenic and cardiovascular risk in children” Dates: 12/01/08-11/30/12 Sponsoring agency: NIH R01 1 R01ES015597 Principal investigator: Eliseo Guallar Funding level: US $399,000 Observational study of the association of lead, cadmium and arsenic with cardiovascular risk in children residing in the Torreon metropolitan area, Mexico. Role: Co-investigator

7. Title of grant: “Race, menthol cigarettes and biomarkers of tobacco use in the US” Dates: 07/01/2010-06/30/2013 Sponsoring agency: NIH R03CA153959 Principal investigator: Ana Navas-Acien Funding level: US $ 81,339 Cross-sectional study in NHANES to evaluate the contribution of menthol cigarettes to race- ethnicity differences in tobacco use and internal dose as measured by tobacco biomarkers. Role: Principal Investigator

8. Title of grant: “DNA methylation and the association of cadmium exposure with chronic kidney disease in a population-based occupational study” Dates: 2010-2011 Sponsoring agency: JHBSPH NIEHS Center Urban Health Principal investigator: Ana Navas-Acien

14 Funding level: US $ 50,000 Main grant objective: Cross-sectional study to investigate the association of the association of urine cadmium levels and DNA methylation alterations in urine from participants screened for kidney disease in the Aragon Workers Health Study (AWHS). Role: Principal investigator

9. Title of grant: “Implementation and outcomes evaluation of a clinical pathway for neurosurgery patients” Dates: 1999 – 2001 Sponsoring agency: Spain’s Medical Research Fund (FIS 94/0144) Principal investigator: Juan Garcia Caballero, University Hospital La Paz, Madrid Funding level: US $20,000 Main grant objective: to implement a clinical pathway for the care of patients in the Department of Neurosurgery and to evaluate the clinical pathway effectiveness. Role: Co-investigator

10. Title of grant: “Secondhand smoke in public places in Latin America” Dates: 2001-2003 Sponsoring agency: Pan American Health Organization (PAHO/WHO) Principal investigator: Ana Navas-Acien Funding Level: US $150,000 Main grant objective: Multi-country cross-sectional survey to assess exposure to secondhand smoke in Public Places in Latin America using airborne nicotine as an indicator. Role: Study coordinator / principal investigator

11. Title of grant: “Heavy metals, obesity, and cardiovascular risk” Dates: 2001-2006 Sponsoring agency: NIH–National Heart Lung and Blood Institute 1R01 HL70299-01 Principal investigator: Eliseo Guallar Funding level: US $1,483,263 Main grant objective: Ancillary study to the Look AHEAD trial to evaluate the impact of chromium level in toenails with the efficacy of a weight loss intervention in patients with type 2 diabetes mellitus Role: Research Assistant

12. Title of grant: “Mercury, fish oils, and risk of myocardial infarction” Dates: 2002-2005 Sponsoring agency: American Heart Association (0230232 N) Principal investigator: Eliseo Guallar Funding level: US $ 260,000 Main grant objective: Case-cohort study of the association of toenail mercury and red blood cell fish oil levels with the risk of coronary mortality in the CLUE 2 cohort Role: Research Assistant

13. Title of grant: “Arsenic exposure, myocardial infarction and diabetes in Washington County, MD” Dates: 2004-2005 Sponsoring agency: Johns Hopkins Center of Excellence for Environmental Public Health Tracking Principal Investigator: Ana Navas Acien Funding Level: US $ 22,500 Main objective: Case-cohort study of the association of toenail arsenic with diabetes and with myocardial infarction in Washington County, MD. Role: Project PI

15 14. Title of grant: “Secondhand Smoke among Women and Children” Dates: 2003-2006 Sponsoring agency: FAMRI No Grant # Principal investigator: Jonathan Samet Funding level: US $ 2,400,000 Main grant objective: Multi-country cross-sectional survey to assess exposure to secondhand smoke, using airborne and hair nicotine as indicators, among women and children in 20 countries from all regions of the world. Role: Co-investigator

15. Title of grant: “Mercury, arsenic, and carotid atherosclerojsis” Dates: 2004-2007 Sponsoring agency: NIH – National Institute of Environmental Health Sciences (1R01ES012673-01) Principal investigator: Eliseo Guallar Funding level: US $ 1,535,017 Main grant objective: Longitudinal study of the association of toenail mercury and arsenic and red blood cell fish oil levels with the progression of carotid intima media thickness, a subclinical marker of atherosclerosis Role: Co-investigator

16. Title of grant: “The FCA Framework Convention on Tobacco Control Monitor” Dates: 2005-2007 Sponsoring agency: Framework Convention Alliance (FCA) No Grant # Principal investigator: Frances Stillman Funding level: US $ 100,000 Main grant objective: Development of a Research Guideline Manual for monitoring the implementation of the Framework Convention on Tobacco Control (FCTC) worldwide. Role: Co-investigator

17. Title of grant: “Lead dose and markers of cardiovascular function in Korean lead workers” Dates: 2006-2007 Sponsoring agency: JHBSPH NIEHS Center Urban Health Principal investigator: Ana Navas-Acien Funding level: US $ 20,000 Main grant objective: Cross-sectional study to investigate the association of lead exposure, as measured in blood, tibia bone and patella bone, with markers of inflammation among lead exposed Korean workers. Role: Principal investigator

18. Title of grant: “Secondhand smoke exposure and diseases of upper airway” Dates: 07/01/2005-01/31/2009 Sponsoring agency: FAMRI Center of Excellence Principal investigator: Ana Navas-Acien Funding level: US $ 597,052 Main grant objective: Case-control study to characterize the effects of exposure to secondhand smoke on risk for diseases of the upper airways. Role: Principal investigator

19. Title of grant: “Secondhand Smoke Exposure among Bar and Nightclub Employees” Dates: 07/01/2006-06/30/2010 Sponsoring agency: FAMRI Grant # 052412 Principal investigator: Ana Navas-Acien Funding level: US $ 325,397

16 Main grant objective: Multi-country cross-sectional survey to assess exposure to secondhand smoke, using airborne and hair nicotine as indicators, among bar and nightclub employees in 20 countries from all regions of the world. Role: Principal investigator

20. Title of grant: “Implementation of the smoke-free compliance guide: country-wide evidence from Turkey” Dates: 06/01/12 – 12/31/16 Sponsoring agency: GITC/BI (Institute for global tobacco control, Bloomberg Initiative) Principal Investigator: Ana Navas-Acien Cluster random sample observational study in 12 cities of Turkey to evaluate the current level of compliance and opportunities for enforcement of the Turkish smoke-free law. Role: Principal investigator

21. Title of grant: “Water pipe secondhand smoke exposure: characterization of environmental toxicants and tobacco biomarkers” Dates: 06/01/12 – 12/31/15 Sponsoring agency: GITC/BI (Institute for global tobacco control, Bloomberg Initiative) Principal Investigators: Patrick Breysse/Ana Navas-Acien Cross-sectional survey to assess exposure to water pipe secondhand smoke, using comprehensive environmental and biomonitoring assessment in Egypt, Turkey and Russia.

Teaching Experience and Responsibility

Columbia University

2016 Environmental Health Sciences Journal Club

2017 - Environmental Epidemiology Connections (interdepartmental discussion forum)

2018 - Member of the PhD Preliminary Oral Exam Committee, Department of Environmental Health Sciences

2017 - IMSD instructor and mPI

2018 - Molecular Epidemiology: Instructor: Ricky Pereira. Lecture: Dose-Response Analyis.

2019 - Environmental Health Determinants II. Instructor: Mary Gamble. Lecture: Tobacco, Metals and Health: Environmental Health Sciences for Public Health Action.

2019 Career Development Panel for the Patient-Oriented Research (POR) Colloquium – CTSA. Course instructors: David Lederer and Daichi Shimbo.

Johns Hopkins University Courses

2007 - 2016 188.840 Environmental Epidemiology Journal Club, meeting bi-monthly

2011 - 2016 340.680.01 Environmental