Anti-KLK10 (Aa 87-260) Polyclonal Antibody (DPABH-04684) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-KLK10 (aa 87-260) polyclonal antibody (DPABH-04684) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Kallikrein 10, also known as normal epithelial cell specific-1 (NES1) and protease serine-like 1 (PRSSL1), is a trypsin-like serine proteinase. Originally described from a subtractive library looking for genes that were down-regulated in breast cancer, kallikrein 10 was thought to be epithelial cell specific. Kallikrein 10 is reported to be up regulated in pancreatic cancer and ovarian cancer, but down regulated in testicular cancer and breast cancer, perhaps due to differential hormonal regulation, or tissue specificities. Breast cancer patients that had elevated kallikrein 10 had a worse prognosis, leading to speculation that kallikrein 10 might be protective in breast cancer, similar to the argument put forth for kallikrein 3 in prostate cancer. Kallikrein 10 is found in high levels in the pancreas and in lower levels in the tonsils, esophagus, skin, brain, testis and ovary. Biological fluids (breast milk, serum, seminal plasma, urine) contain kallikrein 10, the highest levels found in milk. The cerebral spinal fluid (CSF) contains Kallikrein 10, and was reported to be elevated in patients with Alzheimer's disease. Endogenous inhibitors include kallistatin, protein-C inhibitor and 1-proteinase inhibitor, although Kallikrein 10 can be found complexed to a number of different proteinase inhibitors.

Immunogen Recombinant protein fragment corresponding to a region within amino acids 87-260 of Human Kallikrein 10 (Uniprot ID: O43240).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 100 μl

Buffer pH: 7.00; Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol

Preservative None

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

GENE INFORMATION

Gene Name KLK10 kallikrein-related peptidase 11 [ Homo sapiens ]

Official Symbol KLK10

Synonyms KLK10; kallikrein-related peptidase 10; NES1; PRSSL1; kallikrein-10; protease serine-like 1; kallikrein 10 protein 1; kallikrein 10 protein 2; kallikrein 10 protein 3; kallikrein 10 protein 4; kallikrein 10 protein 7; kallikrein 10 protein 8; kallikrein 10 protein 9; kallikrein 10 protein 12; protease, serine-like, 1; normal epithelial cell-specific 1; breast normal epithelial cell associated serine protease;

Entrez Gene ID 5655

Protein Refseq NP_001070968.1

UniProt ID O43240

Function serine-type endopeptidase activity; serine-type peptidase activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]