sign in sign up
<<
Home , Dang (surname), Gestational hypertension, Miscarriage, Qi (Henan), Qi (state)

Origins: Yao Lue (Essentials from the Golden ang uei eony ormula Gui Shao Yao San Cabinet) c. 220, by Zhang T K & P F Zhong-Jing

Tang Kuei and Peony Formula (Dang Gui Shao Yao San) first appeared in the Jin Gui Yao Lue (Essentials from the Golden Cabinet), by Zhang Zhong-Jing, and is often thought to be the oldest formula for the treatment of liver-spleen disharmony. Zhang originally designed the formula to address persistent mild during , with or without . As understanding of the mechanisms of the formula deepened in the subsequent centuries, its range of application expanded considerably.

General Signs/Symptoms The basic pattern addressed by Tang Kuei and Peony Formula (Dang Gui Shao Yao San) is liver overacting on spleen with deficiency, water accumulation, and liver stagnation. As is evident from the large dose of the chief ingredient, white peony root (bai shao), blood deficiency is emphasized. The most common include persistent abdominal pain, edema or sweating in the lower body, irregular , habitual or threatened , post- partum weakness, weakness during pregnancy, premenstrual syndrome, and difficult urination due to deficiency.

Classical Actions 1. Builds and nourishes 2. Softens the liver and 3. Augments spleen qi 4. Unblocks blood blood smoothes liver qi and eliminates water vessels and gently accumulation invigorates blood Ingredients Latin English Percent of Formula Bai Shao (chief) Paeoniae (radix), alba Chinese White Peony root 25.0% Fu Ling (assistant) Poria Poria, Hoelen, Tuckahoe 16.6% Bai Zhu (assistant) Atractylodis Macrocephalae (rhizoma) White Atractylodes rhizome 16.6% Ze Xie (deputy) Alismatis Rhizoma Asian Water Plantain rhizome 16.6% Dang Gui (assistant) Angelicae Sinensis (radix) Dong Quai, Tang Kuei root 12.6% Chuan Xiong (deputy) Chuanxiong Rhizoma Ligusticum Wallichii rhizome 12.6% General Indications / Modern Applications Because it resolves an underlying pattern that is common to a multitude of physiological disruptions, Tang Kuei and Peony Formula (Dang Gui Shao Yao San) has been found to be effective in treating an unusually large array of indications: • Abdominal pain, mild • Dizziness • Luteal insufficiency and persistent • Dysmenorrhea • • Pregnancy, weakness • • Eczema • Memory impairment during • Adnexitis (inflammation • Edema • Meniere’s disease • Pregnancy, unstable of the structures • Fatigue • Menopausal symptoms • Premenstrual syndrome adjacent to the ) • Gastritis, chronic • Menorrhagia • Psoriasis • Allergic rhinitis • Gestational • Menstrual pain • Rheumatoid arthritis • , gestational • Gout • Menstruation, irregular • Sweating, lower body • Anemia, hypochromic • Headaches, vascular • Miscarriage, habitual or • Thrombotic stroke, • Angina • Hemorrhoids threatened prevention of • Anovulation • Hives/urticaria • Nausea • Toxemia of pregnancy, • Back weakness and • regulation and • Ovarian cysts • Trigeminal neuralgia numbness stimulation • Ovarian dysfunction • Ulcers, peptic • Back pain (lower)/sciatica • Hydrocele • Palpitations • Urinary tract stones • Breast hyperplasia • or • Pelvic Inflammatory • Urination, difficult or • Breech presentation in hypertension from Disease (PID) scanty late pregnancy deficiency • Polycystic ovaries • Uterine , • Chilblains • • Post stroke impairment dysfunctional • Cold extremities • Learning disorders due and deterioration • Uterine tumor • Congestive heart disease to deficiency • Postpartum weakness • Varicose veins • • Leiomyoma • • Vertigo • Dementia • Leg weakness • Preeclampsia

Tang Kuei and Peony Formula Monograph © May 2014, Herbal Medicine Press Tang Kuei & Peony Formula 2 increased according to case. 3 times daily, but this can be Standard dosage 2tablets, is D (coumadin). coagulation effect of that it does stasis, clinical studies have shown thehas ability to transform blood Formula Although miscarriage. threatened It avery popular is treatment for Peony Formula of use the support clinical evidence to of body pregnancy and there asignificant is an) S Yao Peony Formula application of pregnancy, but the original to contraindicated be during invigorate blood flow are thought Normally, substances that C thin. thin May slippery, be or weak and P Pale, coating. thin a with T F ormula ongue ulse ontraindica osage • Unblocksbloodvessels and • Augments spleenqi theliver• Softens and • Buildsandnourishesblood gently invigorates blood accumulation and eliminates water smoothes liver qi

was for a condition of of for condition a was

(Dang Gui Shao Yao San) Tang Kuei and Peony A not i c tions Tang Kuei and enhance the anti- tions during pregnancy.during (Dang Gui Shao Tang Kuei and /C autions

modification modification root cause. (See “General Indications /Modern Applications” above.) Yet, with little or no indications varietywide of that it can difficult be to see how allthey can stem from the same out to extraordinarily be common, especially women, in and often is the for basis asuch a Tang Kuei and Peony Formula Formula Discussion Shao YaoShao San) The two deputiesdifferent serve functions in the first place. nourishes the blood that it could to prevent taken be by itself the pattern from developing in address the dampness component the pattern, of derlying . Its primary action to is supplement blood. Although it not does directly ingredient, The chief whitepeony root Synergy of Ingredients heart disease. heavy, abnormal sweating concentrated the in lower body, hydroceles, and even congestive such varied chronic as signs rhinitis, Meniere’s disease, nausea, afeeling that one’s head is urination to confirm the pattern. Today see we the water accumulation component includeto many ways. Zhang looked for edema the in lower limbs, swollen abdomen, and for inhibited (Dang Gui Shao Yao San) these.of What unique about is the pattern addressed by the is as concept liver over-acting of on spleen. There are a formulasnumber of that treatboth Blood deficiency that to qi stagnationis enougheasy withoutgraspto much reflection, effectivelyeven used been to treat certain neurological conditions. and chronic dampness, gastrointestinal, well as as hematologic, disorders. and vascular It has derlying pattern for many and , disorders gynecology of dermatology, pain disorders, splenic failure to transform and transport fluid.disharmony The in whole becomecan un the carriage for the liver qi.second The (and dependent)thedisharmony part of is the resulting tive liver. The the patternrest of would therenot develop if were sufficientblood to provide The root disharmony andthis primary part liverof is deficiencyblood leading tohyperac mild abdominal pain. retention, the especially lower edema of limbs, course, and, of symptom the persistent chief of Zhang Zhong-Jing’stoms of original pattern included hypertonic abdomen with pain, fluid Zhong-Jing understood the development the pattern. of The accompanying and signs symp spleen’s ability to perform its transportation and transformation function.is how This Zhang The hyperactiveliver invades the spleen (a excessWood “overwhelms”Earth), damaging the to sustain the increased production blood, the of liver become will stuck and hyperactive. since the liver blood “carries” the liver qi, the expecting mother if blood is deficient, unableor the liver supplies extra blood to the uterus, which necessary is to maintain the , and spleen. disharmony The this of in root blood of is a deficiencythe liver. During pregnancy, San) Zhang Zhong-Jing first formulated for treating the all indications on the list, provided the underlying pattern amatch. is lamic-controlled pituitary and ovarian functions. treatingin ovarian dysfunction due to the formula’s neuroendocrine effect on the hypotha Ovarian dysfunction— Gynecological kuei ( bai zhu Two the three of assistants, atractylodes and leaching out dampness. It indirectly collaterals opens by removing water accumulation. xie) and proceeds to “move the the qiin blood” order in to alleviate pain. Asian water plantain pain. misunderstood the pattern he seeing was with pregnant women sufferingfrom abdominal Modern Applications formula that control in is blood invigoration. of combined atractylodes are often combined to boost spleen qiand resolve dampness. In addition, Zhang frequently the spleen from damp encumbrance and protect it from the liver’s assault. These substances strongly addresses the water accumulation the pattern of aspect by promoting urination to treat abdominal pain during pregnancy due to adisharmony between the liver and Chuan xiong Chuan dang gui dang strengthens the spleen while the Tang Kuei and Peony Formula ) joins the chief to the) joins help chief nourish the blood, but the also it is substance the in . Ligusticum

enters the the liver blood of and chong the well vessels as (as collaterals) (bai zhu)(bai A Kampo study shown has that is the is resulting fluid accumulation. Fluids may accumulategreatin a (chuan xiong)

with peony (Dang Gui Shao Yao San)

Tang Kuei and Peony Formula (bai shao), (bai might have considered been had the Zhang chief bai shao bai (bai zhu)(bai (bai shao) (bai

Tang Kuei and Peony Formula (Dang Gui Shao Yao San) soothes the liver. The thirdassistant, tang addresses the the all un of major aspects bai shao shao bai and poria to treat liver-spleen disharmony. The Tang Kuei and Peony Formula Dang Gui Shao Yao San treats atwo-part pattern that turns so effectivelyso softens theliver and (fu ling), (fu

(Dang Gui Shao Yao together can rescue can be highly effectivecan be

(Dang Gui is successful successful is -

- (ze (ze - - - Tang Kuei & Peony Formula 3 - -

- , - - - - -

- - - xiii Dang Dang Dang , 217 of 239 ,

for a series of a series for administered administered

xvii was to sup able xv

xviii —A Japanese study —A Japanese xii is effective in is amelio effective Dang Gui Shao Yao San Yao Shao Gui Dang Dang Gui Shao Yao San Yao Shao Gui Dang —A Japanese study investi —A Japanese The results of study results the The (Dang Gui Shao Yao San) San) Yao Shao Gui (Dang

—A study involving 239 preg involving study —A xvi —An animal study in Taiwan con Taiwan in animal study —An Dang Gui Shao Yao San Yao Shao Gui Dang Dang Gui Shao Yao San San Yao Shao Gui Dang Dang Gui Shao Yao San Yao Shao Gui Dang group. The results in this group showed showed this in group results The group. Dang Gui Shao Yao San Yao Shao Gui Dang Dang Gui Shao Yao San Yao Shao Gui Dang —Another Japanese study showed that that showed study Japanese —Another

xiv experienced positive results. After administration of administration After results. positive experienced was successful in treating anemia associated with associated anemia in treating was successful suc of more anemia all symptoms address could

Tang Kuei and Peony Formula Formula Peony and Kuei Tang x Dang Gui Shao Yao San Yao Shao Gui Dang — rating the impairment of spatial memory caused by repeated cerebral cerebral repeated by caused of memory spatial impairment the rating that determined study This in rats. ischemia of cere in treatment be helpful may and action has a neuroprotective ischemia. cerebral by caused dementia brovascular indicated patients, 31 post-stroke including study, clinical Another that the administration of improve and limbs of lower of the impairments progression the press group control The patients. of function post-stoke these cerebral the of lower the impairment more significantly experienced study in this dementia. to leading function cerebral and limbs breech presentations were corrected. This is a 90.8% success rate. Thissuccess is a 90.8% corrected. were presentations breech Dermatological ­ Acne symptoms. well rashes as as incidental acne suppressed effectively formula the Kampo in of activities ingredients the synergistic The of suppression distinct contrast, In effects. these produce might tions of cause The antimicrobials. with found was not symptoms incidental differ and clarified yet been has not antimicrobials in effects adverse Kampo the among of symptoms incidental of degrees ent suppression formulations exist. psoriasis and dermatitis, atopic Eczema, of using effectiveness the gated be to it found and therapy conventional with failed had who patients failed. had therapy conventional where successful Actions Neurological and Circulatory Hematological, due toAnemia that in 1996 indicated ducted injury against hematopoietic protect could therapy radiation to prior of doses radiation. sublethal by caused ischemia cerebral to due impairment Memory that indicates in 2005, Breech presentation in late pregnancy in late presentation Breech with treated were who presentation breech with women nant San Yao Shao Gui of of3-6 doses version a modified the treatment of anemia caused by menorrhagia resulting from uter from resulting of menorrhagia by caused anemia treatment the number relieving a in success significant showed (fibroids), myoma ine oral an received group one period, week Over eight an of symptoms. received other the and supplementation iron of ane symptoms the and counts blood The daily. times three 2.5 g., spoon and of breath shortness standing, upon dizziness as, mia such 80% supplementation. iron oral the with improved were nails, shaped so severe some of degree effects, some side exhibited of group that effects adverse no were There treatment. discontinue to had they that in the the in cold dysmennorrhea, menorrhagia, in improvement significant shoulder and headache dizziness, feet, and hands cold body, lower that group the in improvement no showed symptoms These stiffness. supplementation. iron oral received could oftherapies two the combination a that concluded study The by accompanied fibroids uterine for treatment as a promise offer anemia. pregnancy in Anemia San Yao Shao Gui of consequences negative the also studied study This pregnancy. fetus. unborn the to anemia mother’s the and supplementation of iron oral combination the that showed San Yao Shao Gui used individually. treatment each than cessfully ------

has - - binds vii, viii vii, Dang Gui was effective contains contains Dang Shao Gui —A Japanese —A Japanese was shown to have have to was shown improves luteal in luteal improves was administered for for was administered ­—A study comparing

v was effective in reducing reducing in was effective Dang Gui Shao Yao San Yao Shao Gui Dang Chai Ling Tang Chai Ling Tang

vi Dang Gui Shao Yao San Yao Shao Gui Dang iii was performed on parous rats rats parous on was performed ­—A study done on the estro with estradiol in treating meno in treating estradiol with Dang Gui Shao Yao San Yao Shao Gui Dang to oral iron supplementation oral iron to for —Two studies indicated that the use the that indicated studies —Two these results. these Dang Gui Shao Yao San Yao Shao Gui Dang combined with was conducted in vivo, with a group of a group with in vivo, was conducted —Dysmenorrhea is defined ispainfulmen defined as —Dysmenorrhea Dang Gui Shao Yao San San Yao Shao Gui Dang daily, dosing 2.5g, 3 times daily for more more for daily 3 times 2.5g, dosing daily, has been found to stimulate the synthesis synthesis the stimulate to has been found —A Japanese study in 2004 on preeclampsic preeclampsic in 2004 on study Japanese —A Dang Gui Shao Yao San Yao Shao Gui Dang

ii Dang Gui Shao Yao San Yao Shao Gui Dang Thus iv Dang Gui Shao Yao San Yao Shao Gui Dang Dang Gui Shao Yao San Yao Shao Gui Dang is one of several Kampo formulas that treat the blood blood the treat that of is one formulas Kampo several

Dang Gui Shao Yao San Yao Shao Gui Dang —A clinical study on the effects of Toki-shakuyaku-san Toki-shakuyaku-san of effects the on study clinical —A ix could be used to treat menopausal syndrome by regulating regulating by syndrome menopausal treat be used to could Dang Gui Shao Yao San Yao Shao Gui Dang Dang Gui Shao Yao San) Yao Shao Gui Dang nant rats. nant anemia hypochromic with fibroids Uterine use ofthe Toxemia in Pregnancy Toxemia that indicated rats in preg retardation growth intrauterine and symptoms hypertensive Pregnancy, habitual miscarriage habitual Pregnancy, of disease. autoimmune to due miscarriage repeated in preventing compounds that can improve peripheral blood circulation. blood peripheral improve can that compounds San Shao Yao “oketsu.” as known syndrome stagnation study linked poor peripheral blood circulation to premenstrual syn premenstrual to circulation blood poor peripheral linked study Oth cycles. menstrual normal and regular had who in women drome that shown clearly have er studies and reduced used of NSAIDS. A dosage of 2.5g, three times daily for for daily times three of dosage A 2.5g, used of NSAIDS. reduced and achieve was used to 6 months in women eumenorrheic syndrome Premenstrual up to 20% of women may experience pain severe enough to interrupt interrupt to enough severe pain experience 20% of may to up women When lives. daily their in a Japa of dysmennorhea with a group women to more or 6 months pain reduced significantly showed 100 % of women the study, nese proper proportions to one another. proper proportions one to another. irregularities Menstrual and common is quite This disorder uterus. the involving strual These results would seem to indicate that this formula has a regulat has a formula this that to indicate seem would results These “push” to ability the have not does but levels hormonal on effect ing or range of out levels proper their hormonal any or levels estrogen menstrual cycles. cycles. menstrual normal with women levels in hormonal the on effects adverse no cycles. menstrual The results suggest that that suggest results The yet balance, hormonal proper establishing by women, in sufficiency ofnormal levels with women hormonal the affect adversely does not strual cycles and hormonal levels. All were given 7.5g of the formula 7.5g of formula given the were All levels. hormonal and cycles strual San Yao Shao Gui Dang than three months. verified by blood and urine tests indicated luteal in 35 insufficiency luteal indicated tests urine and blood by verified were (15 women) of group, portion A the study. in this participants men normal had but PMS symptoms exhibiting dysmenorrheic, Infertility ( levels hormonal abnormal and body temperatures Basal 50 women. Yao S an hormone in cases when production hormone stimulating than rather is contraindicated. therapy replacement els than estradiol. The results suggest that that suggest results The estradiol. els than oflevels estrogen stimulation the to opposed as influence a regulatory used in hormome is sometimes which estradiol, from results that that indicate may results These therapy. replacement the effects of effects the that found study The symptoms. pausal lev hormonal effect on hasveryand different a receptors different to Menopause and surgical menopause surgical and Menopause of effects genic compare to waspurpose study’s The been removed. had ovaries whose and release of neurotransmitters, such as acetylcholine, dopamine dopamine as acetylcholine, such of release and neurotransmitters, re this stimulate that enzymes activating by norepinephrine, and brain. insponse the Dang Gui Shao Yao San Yao Shao Gui Dang Tang Kuei & Peony Formula 4 p. 589. xx Neurosciences xix ControlledRandomized Trial, Dept. Japanese of Oriental Medicine, 2009; doi:10.1093/ecam/nep026. xviii cerebral ischemia rats, in xvii 1, pp. 43-48, 1996. xvi Volume 1, Issue 1, Pages 49-62, 2004. xv Research Clinical and Under Experimental Drugs xiv xiii xii 2007. xi Uterine of Cases Myoma, T x (omega)-nitro-L-, ix viii correcting T- helper-1/T-helper-2 balance, vii Chemistry Letter vi v Vol. 30, Issues 2&3, pp. 327-338, 2002. iv Issue 6, pp. 1145-1149, 2008. iii ii Interactions Endnotes i Proctor, M., Farquhar, C., Dysmenorrhea, Dysmenorrhea, C., Farquhar, M., Proctor, Akase, T., al, et A Comparative Study the Usefulness of of Toki-Shakuyaku-san and an Oral Iron Preparation the in Treatment Hypochromic of Anemia in Hagino, N., Kampo medicine:An of overview Toki-Shakuyaku-San (TJ-23), Akihito, M., et al, Effect of several Kampo (JapaneseAkihito, traditional M., al,herbal) et medicines several on Kampoanti-coagulative Effect of activity of Warfarin, Usuki, S., al, et improvement The Luteal of Insufficiency inFecund Women by Tokishakuyakusan Treatment, Takei, H., al, et The herbal medicine Toki-shakuyaku-sanimproves the hypertension andintrauterine growth retardationin preeclampsia ratsinduced by N Chung, M.H., al, et EstrogenicKampo a Effects of Formula, Tokishakuyakusan,in ParousRats,Ovariectomized Kawamura, A., al, et A polyacetylene compound from herbal medicine regulates genes associated with thrombosis endothelial in cells, Akase, T.,of Efficacy Tokishakuyakusan on the inAnemia the Iron-Deficient Rats,Pregnant Hiromi Kobayashi,1 Kuniaki Takahashi, al., et An Alternative Approach to Atopic Dermatitis, Volker, Scheid with Bensky, Dan, Ellis Andrew, and Barolet, Randall, Fujii, T., al, et Theoretical basis for herbal medicines, Tokishakuyaku-san and Sairei-to,in the treatment autoimmunity of related recurrent by Tagawa, K., et al, al, et K., Tagawa, Higaki S, Toyomoto T, Morohashi M, Seijo--to, Jumi-haidoku-to and Toki-shakuyaku-san suppress rashes and incidental symptoms acne in patients, Hsu, H., Lin, C., A preliminary study on the radioprotection mouse hematopoiesis of by Dang-Gui-Shao-Yao-San, J Kitabayashi, Y. al, et traditional Effect of Japanese herbal medicine toki-shakuyaku-san formild cognitiveimpairment: SPECT study, The combination of of The combination Kuei and Peony Formula similarities; blood deficiency, qi stagnation and dampness. These formulas treat patterns that share a combinednumber of and Si Ni San Tang Kuei &Peony Formula, Bupluerum & Tang Kuei Formula Formula Comparisons tion and cases there all in were no adverse effects to the therapy. were performed. Theeight week treatmentimproved cognitivefunc MRI, aSPECT scan and amini-mental state examination (MMSE) with er’s disease. The patientsin this study were treated for eight weeks ment that (amnestic known is to MCI) aprecursor be to Alzheim of Alzheimer’s dementia Fujii, T., Herbal factors the in treatment autoimmunity-related of habitual abortion. Shan Xi Zhong Yi Pu, J., al, et Post-ischemic treatment with toki-shakuyaku-san prevents (tang-gui-shao-yao-san) the impairment spatial memory of induced by repeated Goto, H., al, et HerbalA Chinese Medicine, Tokishakuyakusan, Reduces the Worsening Impairments of and Independence After Stroke, A One Year Dang Gui Shao Yao San and qideficiency, to anda cold tendency other abdominalmassesdueto bloodstasis, blood For uterinecysts fibroids or withanemia, ovarian For pathogenic to invasion exterior tendency with Dang Gui Shao Yao San , Vol. 25, Issue 1, pp. 3-8, 2008. qi deficiency, pregnancy during , Vol. 61, pp. 447- 448, 2007. , Vol. 15:17(24), pp. 6879-6887, 2007.

World Journal Gynecological and Obstetrics (Shanxi Chinese Medicine),(Shanxi Chinese Vol. 12, pg. 534, 1998. Tang Kuei and Peony Formula American Journal of Chinese Medicine Journal Chinese of American Journal Phytomedicine of —A clinical study Japan in tested the effects he Pharmaceutical ofJapan Society he , impair cognitive mild for treatment of is the is oldest formulation the three. of . Prior to and after the treatment, an

Clinical Evidence Clinical American Journal of Reproductive Immunology Reproductive Journal of American , 28(5):193-196, 2002 , 2004. , Vol. 03, pg. 813, 2007. and and , Vol. 31, pp. 66-73, 1979. , Vol. 123, Issue 9, pp. 817-824, 2003. , Vol. 33, Issue 3, pp. 475-89, 2005. U Si Ni San Tang Tang seful Chinese Herbal Medicine: Formulas and Strategies xix -

- C -

Phytotherapy ResearchPhytotherapy ombinations ciency withciency milder blood stasis. persistent pain that accompanied is by dampness and blood defi greatest ability to dampness. dispel This formula treats also milder, these threeOf formulas, when experienced agynecological disorder. part as of All three these formulas of have the ability to treat abdominal pain greater ability to relieve pain due to liver qistagnation. liver the qistagnation three of formulas. Thus San the ability to nourish blood and qiand resolve dampness. ing liver and spleen. nourishing the blood to moving liver qistagnation and harmoniz Formula results aformula in very similar to Vitamins and Use with Use with has thehas least ability to nourish and the greatest ability to move ; Vol. 44, Issue 6, pp. 342-46, 2000. , this combination shifts the the emphasis formula of from Biologic Pharmacology Bulletin Pharmacology Biologic Evidence-Based Complementary and Alternative Medicine Alternative and Complementary Evidence-Based , Vol.7, pp. 391-394,1993. Cinnamon &Poria Formula. JadeFormula. Windscreen Bupluerum and Tang Kuei Formula Tang Kuei and Peony Formula , Vol. 65, pp. 333-344, 2002. The American JournalChinese of Medicine Biological Pharmacology Bulletin Pharmacology Biological xx ournal of Ethnopharmacology, of ournal

, 2nd Edition, Press, (Eastland 2009), Bupluerum and and Bupluerum Tang Kuei , Vol. 30, Issue 8, pp. 1523-1528, Research Actions on Drug and Si Ni San Bioorganic Medical Psychiatry and Clinical Clinical and Psychiatry , Vol. 31, , Vol.31, has a has had the Si Ni also has has also Vol. 55, Issue , - -