Integrated Center Effi cient packaging of solid dose products in

Uhlmann’s Integrated Bottle Center is the world’s first bottle for solid dose products developed entirely in compliance with pharmaceutical principles. Product congestion, tedious format changeovers, and various operating systems from different manufacturers in one production line are a thing of the past.

Uhlmann has systematically transferred its know-how in the development of pharmaceutical packaging solutions to the Integrated Bottle Center. The perfectly integrated, highly flexible and productive line concept optimally combines all the necessary stations. Furthermore, extensions to the bottle filler for solid dose products with additional equipment and machines pose absolutely no problem. Practical examples include the Labeler L 250, Track & Trace, a cartoner or an end-of-line packaging machine.

Integrated Bottle Center.

The new way to package tablets and capsules in bottles.

02 03 The Integrated Bottle Center – an effective concept

Available in two performance categories, the Integrated Bottle Center reduces downtimes to a minimum and offers an unrivaled, efficient packaging process.

One concept, two options: the Integrated Bottle through an Integrated Bottle Center from start to Center 120 is the right choice for the medium output finish. This rules out congestion and micro-stops. range when fast and frequent product changeovers Fast format changeovers, the automatic adjustment are the order of the day. The Integrated Bottle of all machine stations to new bottle heights, Center 240 lays additional emphasis on output. and a central, touchscreen control system for all Common to both versions is firstly the monoblock functions enhance the efficiency and simplify architecture. All the stations required for the operation. The GMP-compliant, table-top design packaging of solid dose products are integrated ensures easy cleaning and the option of modular and optimally coordinated. Secondly, they operate extensions guarantees full potential for future on the same process principle. Bottles are guided applications. 1Don't let go! • The continuous, guided motion bottle transport throughout the machine rules out product congestion and jammed bottles. Ramp-up phases are eliminated.

• The master shift register recognizes the position of every bottle in the Integrated Bottle Center and guarantees 100 percent process control.

• The in-process control and the 100 percent good product philosophy ensure maximum reliability.

2Take-away adjustments! • Fast format changeovers and the automatic adjustment of all machine stations to new bottle heights within a matter of minutes enhance productivity.

• The entire Integrated Bottle Center is controlled via a central touchscreen with access to the format data for all functions.

3Keep it simple! • The Integrated Bottle Center is quick to clean on account of the GMP-compliant, table-top design. Hygiene is also made easier as there are no belt conveyors.

• The modular design of the Integrated Bottle Center allows optional component extensions. Another positive feature is the clear separation of the drive and product areas.

• Use is made of time-tested, reliable technology which has proven its worth in Uhlmann blister machines.

04 05 The Integrated Bottle Center 120 – flexible and productive

Uhlmann’s smaller bottle filler for solid dose products is the ideal solution for the medium output range when frequent and fast product changeovers are required.

The Integrated Bottle Center 120 is a flexible solution The Integrated Bottle Center 120 handles up to 150 for the packaging of many different small to medium- bottles or 24,000 tablets or capsules per minute and sized batches of solid dose products in bottles. The can be reset to a different bottle diameter in just six integrated monoblock operates with a high level of minutes. All the machine stations, as well as the bottle automation and is centrally controlled via a touch- transport, are adjusted to a new bottle height at the screen. On average, it is 20 percent more efficient touch of a button. Furthermore, the large format area than solutions made up of separate components. allows diverse applications. The GMP-compliant, Measuring less than 5 meters, it is also only half the easy-to-clean bottle filler for solid dose products length of a conventional line. processes round, rectangular and oval bottles 45 to 200 milli­meters in height and 25 to 125 millimeters in diameter. Highlights of the Integrated Bottle Center 120

Innovative bottle transport The Integrated Bottle Center 120 does without format parts as a rake is responsible for the continuous product flow from start to finish. It is adjusted to a different bottle diameter in just six minutes. Micro-stops and ramp-up phases are eliminated.

Highly productive Bottles are guided intermittently through the whole Integrated Bottle Center 120. The machine has a maximum output of 150 bottles or 24,000 tablets or capsules per minute.

Very flexible The few format parts and ease of format changeover make the Integrated Bottle Center 120 the ideal bottle filler for solid dose products when the packaging process requires frequent batch changeovers.

Scalable performance What is more important: counting capacity, output or both? The Integrated Bottle Center 120 is available with up to four counting modules and three capping heads.

06 07 Customer Support & Services TopmanTraining

TopmanTraining courses promote your staff’s confidence to handle machines and components, improve their competence to remedy malfunctions, and extend their practice-oriented know-how. Instruction is tailored to your specific needs as well as to the participants’ level of knowledge and the relevant machines.

Format-free bottle transport

A format-free rake takes over the guided motion, camera system to recognize product presence is an intermittent transport of the bottles through the optional feature. The counting modules are pulled out entire machine without interruption. Adjustment to to the back for cleaning purposes. a different bottle height is carried out at the touch of a button. No ramp-up phase is necessary and no Flexible capping unit belt conveyors are used. The dedicated bottle infeed ensures immediate supply and the master shift The mechanically controlled capping unit with slip register recognizes the position of every bottle in clutch automatically removes bottles with incorrectly the machine. It guarantees 100 percent process fitted caps. It handles all common types of caps and control at all times. is optionally available with servo technology and monitoring of the closing torque. The basic model Accurate, scalable tablet counter of the Integrated Bottle Center 120 has two capping heads but an extension to three is possible. The drive system of the separation channels and memory flaps of the tablet counter ensure a contin­ Reliable bottle discharge uous product flow. Infrared technology monitors 100 percent accurate counting and the tapered The bottle discharge functions on the basis of hoppers prevent bridging of the solid dose products. Uhlmann’s “good product” philosophy. Only perfect A dust extraction system and complete enclosure bottles are forwarded to downstream machines such of the product flow protect both operators and the as a labeler or cartoner. Faulty products are removed products. The basic version of the tablet counter from the packaging process at a different point. includes two counting modules. If importance is The in-process control function removes bottles for attached to greater counting capacity and/or output, quality controls at optionally selected intervals via the tablet counter can be fitted with up to four a separate conveyor. counting modules. The integration of an inspection Integrated Bottle Center 120

Technical data at a glance

Output [1/min] up to 150 bottles Solid dose products tablets, capsules

Counting capacity [1/min] up to 24,000 tablets Tablet size

Mode of operation intermittent Length 3 – 30 mm

Bottles Width/diameter 3 – 20 mm

Volume 30 – 1,500 cc Counting accuracy 100%

Material HDPE, Sound level max. 75 dbA

Form round, rectangular, oval Space required

Diameter 25 – 125 mm Basic machine width approx. 2,500 mm

Height 45 – 200 mm Basic machine height approx. 2,370 mm

Types of screw and snap caps, Basic machine length approx. 4,840 mm child-resistant caps

Bottle infeed/ Tablet counter Bottle removal/ transport and feeder unit Operating panel Capping unit in-process control

Discharge conveyor

08 09 The Integrated Bottle Center 240 – performance at its best

240 bottles per minute speak for themselves: anyone in search of a high-performance bottle filler for solid dose prod­ucts is well served with the Integrated Bottle Center 240.

The Integrated Bottle Center 240 is a bottle filler for solid The higher output of the Integrated Bottle Center 240 dose products that meets exacting high-performance is naturally combined with outstanding efficiency. requirements. The compact design combines output The modularly extendable bottle filler for solid dose with perfected process technology. The tablet counter products eliminates ramp-up phases and micro- is available with up to seven counting modules, which stops. The innovative bottle transfer continuously allow the Integrated Bottle Center 240 to attain an guides the bottles through the machine without output of up to 42,000 tablets or capsules per minute. any interruptions. Tool-free format changeovers are Measuring 6.75 meters in length, the machine handles carried out within a matter of minutes. All the stations round, rectangular or oval bottles; bottles may range of the machine are optimally integrated and operated from 48 to 193 millimeters in height and from 35 to via a central, touchscreen control system. 100 millimeters in diameter. Highlights of the Integrated Bottle Center 240

Continuous bottle transport Feeds screws guide the bottles without interruption through the Integrated Bottle Center 240. They can be changed to different bottle formats within a matter of minutes at the touch of a button. Micro-stops and ramp-up phases are eliminated.

High performance, small footprint The Integrated Bottle Center 240 is available with five, six or seven counting modules and can handle up to 42,000 tablets or capsules per minute. The overall length of the machine is just 6.75 meters.

Modular extensions All the stations required for the packaging of solid dose products in bottles are combined in the Integrated Bottle Center 240. The integration of additional stations for functions such as and wad or desiccant feeding, as well as the inclusion of a metal detector, is possible at all times.

Viable investment The Integrated Bottle Center 240 offers an outstanding price-performance ratio. The efficient mode of operation and the diverse application possibilities of this bottle filler for solid dose products mean that it pays off within a very short time.

10 11 Integrated Bottle Center 240

Smooth-running bottle transport

Feed screws gently guide the bottles through the Integrated Bottle Center 240 and eliminate the need for belt conveyors. The continuous motion transport system rules out micro-stops. Error-proof, plug-in connections allow quick and easy fitting of the feed screws, and they can be adjusted to other bottle formats in a matter of minutes. The dedicated bottle infeed ensures immediate supply. The master shift register guarantees process reliability because it recognizes the position and status of every bottle in the line. It controls the filling process as required and only forwards perfect products for downstream processing.

Innovative, guided motion bottle transport Tablet counter and feeder unit Customer Support & Services Maintenance

Smooth production over many years is not a matter of chance, but the result of targeted maintenance. Conse- quently, Uhlmann offers you tailored maintenance agree- ments suited to your specific production processes and machinery. The objective is to recognize wear and tear Highly efficient tablet counter in advance and to guarantee the maximum efficiency of your production lines. The packages combining preventive and proactive measures reduce downtimes and improve The tablet counter has six feed tracks, the vibration productivity. of which is individually adjustable, and is optionally fitted with five, six or seven counting modules. Three vibration plates are responsible for the good separation of the solid dose products and an efficient extraction system guarantees the removal of dust and breakage Flexible capping unit particles. Proven infrared technology governs precision counting of the solid dose products. The integration The capping unit handles all forms of caps, even of an inspection camera system to recognize product child-resistant ones. It is available as a mechanical presence is an optional feature. Every counting module system with slip clutch or as a servo-regulated can be pulled out of the back for cleaning purposes. system with monitoring of the closing torque. An added feature in terms of process reliability is the removal of bottles with incorrectly fitted caps. Caps without a sealing film are rejected before they reach the sealing station. As with all stations of the Integrated Bottle Center 240, the capping unit automatically adjusts to different bottle heights. The plug-in system allows the fast changeover of format parts.

Servo-regulated capping unit with monitoring of Plug-in system allows easy format changeover the closing torque 12 13 Optional induction sealing Reliable bottle discharge

A speed-regulated induction sealing station can be Like all Uhlmann packaging machines, the Integrated added to the Integrated Bottle Center 240 if required. Bottle Center 240 benefits from the company’s “good It ensures uniform, top quality sealing. The height of product” philosophy. At the end of the machine, only the bottles is monitored before they are forwarded for perfect bottles are forwarded for downstream sealing. The induction sealing station is also operated processing. Faulty products are removed from the via the central touchscreen control system. packaging process. Bottles for in-process controls are removed at optionally defined intervals and leave the machine on a separate conveyor.

Numerous options

Various optional stations and extensions are available for the Integrated Bottle Center 240. A desiccant feeder, for example, can be integrated into the tablet counter and feeder unit. Other options include a cottoner or a metal detector.

Tool-free format changeover of the bottle transport system Central operation via touchscreen control system Integrated Bottle Center 240

Technical data at a glance

Output [1/min] up to 240 bottles Solid dose products tablets, capsules

Counting capacity [1/min] up to 42,000 tablets Tablet size

Mode of operation continuous Length 2 – 30 mm

Bottles Width/diameter 2 – 20 mm

Volume 30 – 950 cc Counting accuracy 100%

Material HDPE, glass Sound level max. 75 dbA

Form round, rectangular, oval Space required

Diameter 35 – 100 mm Basic machine width approx. 2,600 mm

Height 48 – 193 mm Basic machine height approx. 2,900 mm

Types of closure plugs, screw and snap Basic machine length approx. 6,750 mm caps, child-resistant caps

Tablet counter Bottle infeed/ and feeder unit transport

Capping unit Bottle removal Operating panel

In-process control

14 15 The Labeler L 250 – efficient and accurate

A large format area and straightforward format changeovers: the Labeler L 250 perfectly complements the Integrated Bottle Center 120 and 240.

The Labeler L 250 accurately applies to up The GMP-compliant Labeler L 250 can be linked to to 250 bottles per minute without any misalignment. the Integrated Bottle Center 120 or 240. The machine It handles cylindrical plastic or glass is operated via the same self-explanatory, touch- between 25 and 125 millimeters in diameter. The screen control system. The labeler is fully enclosed highly efficient machine only has one format part with safety glass panels, is easily accessible, and so a tool-free format changeover takes just can be optionally fitted with different marking and one minute. monitoring systems. Highlights of the Labeler L 250

Perfect results A rotary star accurately guides the bottles to the application position of the Labeler L 250. Partial or full wrap-around labels are applied by a wrapping belt. Even at high speed, spiral misalignment of the labels is ruled out.

Fast format changeover The L 250 is quickly and easily adjusted to a new product format. No tools are required. All the format settings can be stored and reproduced via the central machine control system of the Integrated Bottle Center.

Easy reel replacement The label and backing reels also allow tool-free replacement. The ergonomic position of the reel unwind and rewind supports allows quick and easy handling.

Optional systems Marking systems such as a hot stamping unit or a thermal transfer, inkjet or laser printer can be integrated. Optional monitoring systems include inspection cameras, scanners, sensors, code readers or devices for print and label integrity control.

16 17 Customer Support & Services 24h Service

Uhlmann machines stand for cutting-edge technology. However, if the worst comes to the worst, we offer prompt and reliable assistance. We are available 365 days a year through our 24h Service hotline. In 90 percent of cases, we are able to provide immediate help, e.g. through remote access to the machine control system. Otherwise a specialist personally attends to the problem the following workday.

Efficient label unwind Accurate label application

The label unwind handles labels and backing paper The rotary star of the Labeler L 250 guides the reels up to 400 millimeters in diameter. No tools bottles to the label application position where partial are required to replace the reels. Warning signals or full wrap-around labels are accurately applied by indicate imminent reel replacement, enhancing a wrapping belt without any misalignment. This is productivity. This also applies to the optional second the only format part in the labeler and its tool-free label unwind and splice functions. replacement takes just one minute. The label appli- cation has a large format area and monitors the Flexible marking and inspection units presence of a label on each bottle.

Depending on the optional fitting, the marking unit Reliable bottle discharge is capable of hot stamping or thermal transfer, inkjet or laser . Furthermore, the inspection unit is The format-free bottle discharge only forwards capable of monitoring product quality, print quality, perfect products for downstream processing. Faulty print presence or applied codes as required. Both products are removed separately. units are easy to adjust and can be fitted with Trace & Track by Uhlmann.

The rotary star ensures straight labeling The bottle discharge only forwards perfect products for downstream processing Labeler L 250

Technical data at a glance

Output [1/min] up to 250 bottles Labels

Mode of operation continuous Speed dispensing head max. 75 m/min

Bottles Backing paper reel width max. 170 mm

Material plastic, glass Sound level max. 75 dbA

Form round Space required

Diameter 25 – 125 mm Basic machine width approx. 1,700 mm

Height 47 – 220 mm Basic machine height approx. 2,860 mm

Basic machine length approx. 2,130 mm

Bottle discharge Marking and inspection Label application

Label unwind Operating panel

18 19 From start to finish – Uhlmann all along the line

The discharge conveyor of the Integrated Bottle Center is not the end. Uhlmann also offers cartoners and end-of-line packaging machines for combination with the bottle filler for solid dose products.

Decades of experience in the development of operated via a uniform, self-explanatory control solutions for all aspects of pharmaceutical packaging, system. The result is maximum efficiency with a profound understanding of technical processes, a highly automated, smooth-running packaging and a wide spectrum of products set Uhlmann apart. process. From start to finish. A selection of cartoners and end-of-line packaging machines are available for combination with the Uhlmann offers intermittent or continuous motion Integrated Bottle Center 120 and 240 in accordance cartoners, stretch-banding machines, an over­ with individual requirements. Such line integration wrapper, packers and a palletizer. Full line promises many benefits: all upstream and down- integration from a single source means that one stream machines form a perfectly coordinated line contact person serves all customer needs.

For added process reliability

Similar to the uncomplicated integration of upstream and downstream machines, the Integrated Bottle Center can also be upgraded to include systems to enhance process reliability. These include inspection cameras to recognize the presence of tablets or an innovative Track & Trace solution. The marking of bottles with 2D codes meets requirements for the seamless traceability of pharmaceutical supply Line combination: bottle filler, cartoner, end-of-line-packaging machine

chains. More and more countries are introducing registers the codes and stores the information in legislation in this context. the Uhlmann tracking database. This data can be accessed at all times and is linked with the information Track & Trace by Uhlmann was developed together from the next largest packaging unit, i.e. with the with the company’s center of excellence for inspection code on the . Track & Trace can be installed and marking systems, Uhlmann VisioTec. The system in the Integrated Bottle Center from the start or solution marks the base of the bottles and the labels retrofitted at all times. with 2D codes relating to production data. A camera

20 21 Guaranteed process quality from a single source. Customized solutions that meet every need from the concept to the fully integrated line.

Example of a Customized Packaging System: a synchronized packaging line for the production of multiphase blisters with downstream secondary packaging. All process steps throughout the line are optimally coordinated and accurately monitored – from the blister machine and cartoner to the packed cases on .

Uhlmann specialists develop and realize customized whole. This includes design and feasibility studies, packaging solutions from the company’s extensive support in the development of packaging materials range of blister machines, counting and filling machines and blister configurations, the integration of additional for solid dose products in bottles, cartoners, stretch- components or software packages. Furthermore, as banding machines, overwrapper, case packers and a general supplier, Uhlmann takes over responsibility palletizer. Optimum combination of the line components for the project management and offers a one-stop ensures perfect integration into the respective pro- turnkey service. Coordination and scheduling, logistical duction environment. support, quality assurance, documentation, validation, communication, best possible workflows and on-site The focus is not only on the systematic combination support are all part of the package. of machines but also on the production process as a Productive line combinations

Requirement: packaging of solid dose products in blisters, , cases and on pallets Stretch-banding Blister machines Cartoners Case packers Palletizer machines, Overwrapper

B 1240

max. 250 blisters/min. *optional output upgrade B 1330 C 130 max. 300 blisters/min. max. 150 cartons/min. S 3015, S 3025, UPS 5 C 2155 S 3040 max. 400 blisters/min. max. 150 cartons/min. max. 150/300/400 (500*) B 1550 C 2156 cartons/min. or max. 500 blisters/min. max. 150 cartons/min. 15/30/40 (50*) bundles/min. E 4040, E 4046 max. 400 (500*) P 5020 UPS 1030 ET C 2206 E 3025, E 3040 cartons/min. max. 20 operating max. 560 blisters/min. max. 200 cartons/min. max. 300/400 (500*) or 60 bundles cycles/min. cartons/min. or UPS 1030 C 2205 in 10/6 cases max. 600 blisters/min. max. 250 cartons/min. 30/40 (50*) bundles/min. UPS 1040 C 2305 E 3060 max. 600 blisters/min. max. 300 cartons/min. max. 500 cartons/min. B 1660 C 2504 or 60 bundles/min. max. 750 blisters/min. max. 500 cartons/min. B 1880 max. 1,300 blisters/min.

Packaging lines incorporating a blister and a cartoner module

Blister Express Center 300 max. 300 blisters/min. and max. 150/300 cartons/min. Blister Express Center 500 max. 500 blisters/min. and max. 500 cartons/min.

Requirement: packaging of liquid dose products in blisters, cartons, cases and on pallets Stretch-banding Blister machines Cartoners Case packers Palletizer machines, Overwrapper

S 3015, S 3025, S 3040 C 130 max. 150/300/400 (500*) max. 150 cartons/min. cartons/min. or B 1240 C 2155 max. 250 blisters/min. 15/30/40 (50*) bundles/min. E 4040, E 4046 max. 150 cartons/min. max. 400 (500*) P 5020 UPS 5 E 3025, E 3040 C 2156 cartons/min. max. 20 operating max. 400 blisters/min. max. 300/400 (500*) max. 150 cartons/min. or 60 bundles cycles/min. cartons/min. or UPS 1030 ET C 2206 in 10/6 cases max. 560 blisters/min. 30/40 (50*) bundles/min. max. 200 cartons/min. E 3060 max. 500 cartons/min. or 60 bundles/min.

Requirement: counting of solid dose products and packaging in bottles, cartons, cases and on pallets

Counting and filling Stretch-banding Cartoners Case packers Palletizer machines machines, Overwrapper

Integrated C 2155 S 3015, S 3025, E 4040, E 4046 Bottle Center 120 max. 120 cartons/min. S 3040 max. 150 bottles/min. max. 150/300/400 (500*) max. 400 (500*) P 5020 C 2156 cartons/min. or cartons/min. max. 20 operating Integrated max. 150 cartons/min. Bottle Center 240 15/30/40 (50*) bundles/min. or 60 bundles cycles/min. max. 240 bottles/min. C 2206 E 3025, E 3040 in 10/6 cases max. 200 cartons/min. max. 300/400 (500*) C 2205 cartons/min. or Labeler max. 250 cartons/min. 30/40 (50*) bundles/min. E 3060 L 250 max. 500 cartons/min. max. 250 bottles/min. or 60 bundles/min.

22 23 The complete range of support services

A full range of top quality machines for diverse is based on four customer-focused modules: Format applications – that is one aspect of Uhlmann’s and Spare Parts, Professional Assistance, Machine expertise. The other is the company’s Customer Efficiency, and Process Reliability. These are subdivided Support & Services division. This center of excellence into individual support services that serve the smooth

Format and Spare Parts Professional Assistance

• TopTools • Maintenance • Spare Parts • 24h Service • E-Shop • NetSupport • PartsManager

Top quality is a matter of course as far as Consistent machine availability is one of the new format parts, spare parts and tools are prerequisites for efficient packaging. Preventive concerned. However, only a TopTool from and proactive maintenance ensure production Uhlmann guarantees maximum precision, reliability. Online remote maintenance via plug-and-play reliability and top performance. NetSupport and the 24h telephone hotline Furthermore, original spare parts can be provide prompt support in urgent cases. ordered quickly as required – through the E-Shop in Internet or by using the electronic spare parts catalog on CD-ROM. operation of a machine or line after installation. coordinated, globally represented service team. They can be selected and combined as required on For maximum flexibility, reliability and efficiency over the basis of individual customer advice and support. the entire life cycle of a machine. In short: customer Prompt, uncomplicated expertise offered by a well- support services with added value.

Customer Support & Services for maximum added value

Machine Efficiency Process Reliability

• Upgrades • Personnel Training • Production Analysis and • Validation and Calibration Output Optimization • Film Competence Center • Production Support

Efficiency has many facets. Effective workflows, Uhlmann meets all requirements in terms of state-of-the-art technology, optimum packaging process reliability. Support services cover materials, qualified personnel. To ensure full TopmanTraining for well-trained staff, Validation use of the potential of all different packaging and Calibration for tested and documented processes, Uhlmann offers a whole range of production, and the Film Competence Center solutions for greater efficiency. for optimized packaging materials.

Would you like to learn more about the Uhlmann support services? Visit www.uhlmann.de or request the brochure on the complete range of support services by sending an e-mail to [email protected].

24 25 The principle of success: thinking in pharmaceutical dimensions

How can a medium-sized family company manage edge: with more than 7,000 machines operating in to not only retain but continuously improve its 80 countries throughout the world. With a compre­ standing in today’s world? How is it possible to use hensive product portfolio supplemented by the product one’s own strength to shape the pharmaceutical ranges of Uhlmann VisioTec and KOCH Pac-Systeme. packaging market in such a sustained manner in competition with com­petent machine construction Proximity to the customer and proximity to the companies? The answer is simple: Multum non multa. markets: alongside technological competence that is Quality not quantity. the second criterion for success. Uhlmann has over 40 representatives worldwide. Companies of the Concentration on one thing continues to be the Uhlmann Group operate in the USA, Brazil, the UK, company’s motto to this day: the packaging of Sweden, Spain, Russia, Switzerland, Singapore and pharma­ceutical products and nothing else. This is the China. Altogether, some 1,300 people work in a corpo- strategic philosophy that defines Uhlmann’s standards rate culture environment dedicated to total quality. and governs their implementation as market-oriented Every day they readdress a single issue: optimization concepts. This philosophy has given Uhlmann a leading of the packaging process.

You will find more technical information on Uhlmann machines at www.uhlmann.de and in the detailed product brochures. Brochures are available through the website or can be requested by sending an e-mail to [email protected]. The Uhlmann headquarters in Laupheim, Germany accommodate Development, Design Engineering and Production

Multum non multa. Quality not quantity.

Uhlmann Packaging Systems L.P. in Towaco, New Jersey, USA 26 27 Uhlmann Pac-Systeme Uhlmann Packaging Systems L.P. GmbH & Co. KG 44, Indian Lane East Uhlmannstrasse 14 - 18 Towaco, N.J. 07082 88471 Laupheim USA Germany Phone +1 973 4028855 Phone +49 (0)7392 702-0 Fax +1 973 3169330 Fax +49 (0)7392 18972 www.uhlmann-usa.com www.uhlmann.de

Uhlmann VisioTec GmbH Uhlmann Pac-Systems Ibérica S. L. OOO Pharma Union Uhlmannstrasse 14 - 18 Sector Escultores Kutuzovsky Prospect 7/4 88471 Laupheim Avenida de Colmenar Viejo, 4-5 Building 6, Office 26 Germany 28760 Tres Cantos, Madrid 121248, Moscow Phone +49 (0)7392 702-0 Spain Russia Fax +49 (0)7392 702-8539 Phone +34 918 060960 Phone +7 (495)933 7747 www.uhlmann-visiotec.com Fax +34 918 060961 Fax +7 (495)933 7749 | e 2,000 | We reserve the to right make alterations in line with technical development. www.uhlmann.es www.pharmaunion.ru Uhlmann Höfliger Schweiz GmbH Talstrasse 40 Uhlmann Nordiska AB Uhlmann Singapore LLP 4144 Arlesheim Gruvgatan 33 1 Kim Seng Promenade Switzerland 421 30 Västra Frölunda # 14-03/04 Great World City East Tower Phone + 41 (0)61 7022370 Sweden Singapore 237994 Fax + 41 (0)61 7022373 Phone +46 (0)31 450505 Phone +65 673 43150 www.uhlmann-hoefliger.ch Fax +46 (0)31 452505 Fax +65 673 48412 04/2011 | Heidenheim gmbh, becker www.uhlmann-nordiska.se www.uhlmann.de Uhlmann UK Ltd. 6 Lakeside Business Park Uhlmann Técnica Ltda. Uhlmann Packaging Systems

Swan Lane, Sandhurst, Rua José Bonifácio de Andrade e Silva, 40 (Shanghai) Co. Ltd. and Concept design: Berkshire GU47 9DN 12955-000 Bom Jesus dos Perdões (SP) Unit 1805, Silver Tower Great Britain Brazil N. 218 South Xi Zang Road Phone +44 (0)1252 743-120 Phone +55 11 4012 4375 Shanghai 200021 Fax +44 (0)1252 743-133 www.uhlmann.com.br People’s Republic of China www.uhlmann.de Phone +86 21 3302 8658 Fax +86 21 3302 8659 www.uhlmann.cn