This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.

Research Articles: Cellular/Molecular

Global Analysis of Protein Expression of Inner Ear Hair Cells

Ann E. Hickox1,*, Ann C. Y. Wong2,3,*, Kwang Pak2, Chelsee Strojny1, Miguel Ramirez1, John R. Yates4, Allen F. Ryan2,** and Jeffrey N. Savas1,**

1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA 2Departments of Surgery & Neuroscience, University of California San Diego and Veterans Administration Medical Center, La Jolla, CA, 92093, USA 3Translational Neuroscience Facility, Department of Physiology, UNSW Australia, Sydney, NSW 2052, Australia 4Chemical Physiology and Molecular and Cellular Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA

DOI: 10.1523/JNEUROSCI.2267-16.2016

Received: 17 July 2016

Revised: 29 November 2016

Accepted: 19 December 2016

Published: 30 December 2016

Author contributions: A.E.H., A.C.Y.W., K.P., C.S., M.R., A.F.R., and J.N.S. performed research; A.E.H., A.C.Y.W., K.P., J.Y., A.F.R., and J.N.S. contributed unpublished reagents/analytic tools; A.E.H., A.C.Y.W., K.P., C.S., A.F.R., and J.N.S. analyzed data; A.E.H., A.F.R., and J.N.S. wrote the paper; A.F.R. and J.N.S. designed research.

Conflict of Interest: The authors declare no competing financial interests.

*A.E.H. and A.C.Y.W. contributed equally to this work.

**A.F.R. and J.N.S. are co-last authors with equal contributions to the supervision of the work presented.

Research was supported by NIDCD R00 DC-013805 to J.N.S., VA Research Service BLS Grant BX001295 to A.F.R., and the Garnett Passe and Rodney Williams Memorial Foundation Research Fellowship to A.C.Y.W. J.R.Y. is supported by NIH grants P41 GM103533 and R01 MH067880. We are grateful to Jaime Garcia- Añoveros, Ann Hogan, Kazuaki Homma, and Jing Zheng for helpful comments and feedback on manuscript content and clarity.

Correspondence should be addressed to: Dr. Jeffrey N Savas, Department of Neurology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Ward 12-102, Chicago, IL 60611-4296, [email protected]; and Dr. Allen F Ryan, Department of Surgery, University of California, San Diego, 9500 Gilman Drive #0666, La Jolla, CA 92093, [email protected]

Cite as: J. Neurosci 2016; 10.1523/JNEUROSCI.2267-16.2016

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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process.

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Ϯϳϴ Comparison with RNA-seq data

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Ϯϵϳ 

Ϯϵϴ Relating inner ear proteins to mouse auditory/vestibular impairment

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ϯϮϭ 

ϯϮϮ Relating inner ear proteins to human deafness

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