Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sunburn

Total Page:16

File Type:pdf, Size:1020Kb

Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sunburn Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Sunburn Chemical Activity Count (+)-8-16-BETA-HYDROXYBERSALDEGENIN-1,3,5-ORTHOACETATE 1 (+)-8HYDROXYCALAMENENE 1 (+)-ALLOMATRINE 1 (+)-ALPHA-VINIFERIN 3 (+)-AROMOLINE 1 (+)-CASSYTHICINE 1 (+)-CATECHIN 8 (+)-CATECHOL 1 (+)-DIMETHYLISOLARICIRESINOL-2-ALPHA-XYLOSIDE 1 (+)-EPIPINORESINOL 1 (+)-EUDESMA-4(14),7(11)-DIENE-3-ONE 1 (+)-GALBACIN 1 (+)-GALLOCATECHIN 3 (+)-HERNANDEZINE 1 (+)-ISOCORYDINE 1 (+)-MATRINE 1 (+)-PSEUDOEPHEDRINE 1 (+)-SYRINGARESINOL 1 (+)-SYRINGARESINOL-DI-O-BETA-D-GLUCOSIDE 1 (+)-T-CADINOL 1 (-)-16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 (-)-ALPHA-BISABOLOL 3 (-)-ALPHA-HYDRASTINE 1 (-)-ARGEMONINE 1 (-)-BETONICINE 1 (-)-BISPARTHENOLIDINE 2 (-)-BORNYL-CAFFEATE 2 Chemical Activity Count (-)-BORNYL-FERULATE 2 (-)-BORNYL-P-COUMARATE 2 (-)-CENTROLOBINE 1 (-)-DICENTRINE 2 (-)-EPIAFZELECHIN 1 (-)-EPICATECHIN 7 (-)-EPICATECHIN-3-O-GALLATE 1 (-)-EPICATECHIN-GALLATE 1 (-)-EPIGALLOCATECHIN 4 (-)-EPIGALLOCATECHIN-3-O-GALLATE 1 (-)-EPIGALLOCATECHIN-GALLATE 8 (-)-HYDROXYJASMONIC-ACID 1 (-)-KAUR-16-EN-19-OIC-ACID 1 (-)-MAACKIAIN-3-O-GLUCOSIDE 1 (1'S)-1'-ACETOXYCHAVICOL-ACETATE 5 (15:1)-CARDANOL 3 (2R)-(12Z,15Z)-2-HYDROXY-4-OXOHENEICOSA-12,15-DIEN-1-YL-ACETATE 1 (2Z,8Z)-10-ANGELOYLOXY-MATRICARIA-ESTER 2 (5R,8R,9S,10R)-12-OXO-ENT-3,13-CLERODIEN-15-OIC-ACID 1 (7R,10R)-CAROTA-1,4-DIENALDEHYDE 1 (E)-2-HEXENAL 1 (E)-4-(3',4'-DIMETHOXYPHENYL)-BUT-3-EN-OL 3 (Z)-1,3-BIS(4-HYDROXYPHENYL)-1,4-PENTADIENE 1 (Z)-1,8-PENTADECADIENE 1 1'-ACETOXY-EUGENOL-ACETATE 1 1'-ACETOXYCHAVICOL-ACETATE 1 1,10-EPOXYNOBILIN 1 2 Chemical Activity Count 1,2,11,13,2,3'-HEXAHYDROVERNODALIN 2 1,2,4-TRIHYDROXYHEPTADECA-16-ENE 1 1,2,6-TRI-O-GALLOYL-BETA-D-GLUCOSE 1 1,2-DIHYDROXY-4-GLUCOSYLNAPTHALENE 1 1,3,4,5-TETRACAFFEOYLQUINIC-ACID 1 1,3,5-TRIMETHOXYBENZENE 1 1,4-NAPHTHOQUINONE 2 1,4-NAPTHAQUINONE 1 1,5-DIHYDROXY-8-METHOXYXANTHONE 1 1,7-BIS(3,4-DIHYDROXYPHENYL)HEPTA-4E,6E-DIEN-3-ONE 1 1,7-BIS-(4-HYDROXYPHENYL)-1,4,6-HEPTATRIEN-3-ONE 1 1,8-CINEOLE 5 1-ACETOXYCHAVICOL 1 1-ACETOXYEUGENOL 1 1-ACETYLJATIVATRIOL 1 1-ETHYL-BETA-CARBOLINE 1 1-MAACKIAIN 1 1-METHOXYCANTHIN-6-ONE 2 1-O-(2,3,4-TRIHYDROXY-3-METHYL)-BUTYL-6-O-FERULOYL-BETA-D-GLUCOPYRANOSIDE 1 1-PENTADECENE 1 1-TULIPOSIDE-A 2 1-TULIPOSIDE-B 2 10-ACETOXY-8-HYDROXY-9-ISOBUTYLOXY-6-METHOXYTHYMOL 2 10-DEHYDROGINGERDIONE 1 10-EPIEUPATOROXIN 1 10-GINGERDIONE 1 10-HYDROXYCAMPTOTHECIN 4 3 Chemical Activity Count 10-METHOXYCAMPTOTHECIN 1 11-DIHYDRO-CANTHINE-6-ONE 1 11-HYDROXY-DELTA-8-THC 1 11-HYDROXY-DELTA-9-THC 1 12,118-BINARINGIN 1 12-ACETYLDEHYDROLUCICULINE 1 12-HYDROXYDAPHNETOXIN 1 13',II8-BIAPIGENIN 3 13-OXYINGENOL-ESTER 1 15-ALPHA-ACETOXYKAUREN-19-OIC-ACID 1 15-NONACOSANONE 1 16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 16-ANHYDROGITOXIGEN 1 16-BETA-HYDROXYBERSALDEGENIN-1-ACETATE 1 16-BETA-HYDROXYBERSALDEGENIN-3-ACETATE 1 16-HYDROXYINGENOL-ESTER 1 16-HYDROXYPSEUDOJOLKINOLIDE 1 16-PROPIONYLGITOXIGENIN 1 2',6'-DIMETHOXY-4'-HYDROXYACETOPHENONE 1 2'-ACETYLNERIIFOLIN 1 2'-HYDROXY-4,6'-DIMETHOXY-3'-METHYLDIHYDROCHALCONE 1 2'-HYDROXY-FLAVONE 1 2'-O-GLYCOSYLVITEXIN 1 2,3,7-TRIHYDROXY-5-(3,4-DIHYDROXY-E-STYRYL)-6,7,8,9-TETRAHYDRO-5H- 1 BENZOCYCLOHEPTENE 2,3-DIHYDROXYBENZOIC-ACID 1 2,3-DIHYDROXYETHOXYACETOPHENONE 1 2,4,6-TRIMETHOXYPHENOL 1 4 Chemical Activity Count 2,4-DIHYDROXY-6-METHOXY-3-METHYL-ACETOPHENONE 1 2,4-DIHYDROXY-6-METHOXY-3-METHYL-ACETOPHENONE-2-BETA-GLUCOSIDE 1 2,6-DIMETHOXY-P-BENZOQUINONE 1 2,7-DIHYDROXYCADALENE 1 2,7-DIMETHOXY-5-ISOPROPYL-3-METHYL-8,1-NAPTHALENE-CARBOLACTONE 1 2-(3',4-DIPHENYL)-ETHANOL 1 2-AMINO-1,4-NAPTHOQUINONE 2 2-AMINO-4-METHYLHEX-5-YNOIC-ACID-(2S,4R)-2-AMINO-4-HYDROXYHEPT-6-YNOIC-ACID 1 2-BETA,3BETA-27-TRIHYDROXYOLEAN-12-ENE-23,28-DICARBOXYLIC-ACID 1 2-CAFFEOYL-OXY-3-{2-(4-HYDROXYBENZYL)-4,5-DIHYDROXY}PHENYLPROPIONIC-ACID 1 2-EPICUCURBITACIN-B 1 2-HEXEN-1-OL 1 2-HYDROXY-5-ISOPROPYL-7-METHOXY-3-METHYL-8,1-NAPTHALENE-CARBOLACTONE 1 2-METHOXYPHASEOLLINISOFLAVON 1 2-NAPTHOL 1 2-NONANONE 1 2-PHENYLETHYL-ISOTHIOCYANATE 1 2-PROPENE-1-SULFINOTHIOCIC-ACIDS-2-PROPENYL-ESTER 1 20-DEOXYINGENOL-ESTER 1 22BETA-ESCIN 1 24-METHYLENE-CYCLOARTANOL 3 25,26-DIHYDROPHYSALIN-C 1 25,26-DIHYDROPHYSALIN-D 1 3',4',5,6,7,8-HEXAMETHOXYFLAVONE 1 3',4',5,7-TETRAHYDROXYFLAVONE 1 3',5,7-TRIHYDROXY-3,4'-DIMETHOXYFLAVONE 1 3'-DEMETHYLPODOPHYLLOTOXIN 1 5 Chemical Activity Count 3'-FORMYL-2',4',6'-TRIHYDROXY-5'-METHYLDIHYDROCHALCONE 1 3'-O-METHYL-CATECHIN 1 3'-O-METHYLBATATASIN-III 1 3,3'-DIINDOLYMETHANE 2 3,3'-DIMETHYLELLAGIC-ACID 1 3,3'-INDOYL-DIMETHANE 1 3,4,5-TRI-O-CAFFEOYLQUINIC-ACID 1 3,4-DICAFFEOYL-QUINIC-ACID 2 3,4-DIHYDROXYBENZOATE 1 3,4-DIHYDROXYBENZOIC-ACID 1 3,4-DIMETHOXYTOLUENE 1 3,4-HYDROXYCINNAMIC-ACID 1 3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER 2 3,4-SECOTRACHYLOBANOIC-ACID 2 3,4-SECOTRITERPENE-ACID-20-EPI-KOETJAPIC-ACID 2 3,5'-DIALLYL-2'-HYDROXY-4-METHOXYBIPHENYL-ETHER 1 3,5,8,3',4'-PENTAHYDROXYFLAVONE 1 3,5-BIS(3-METHYL-2-BUTENYL)-4-METHOXY-BENZOIC-ACID 1 3,5-DI-O-CAFFEOYLQUINIC-ACID 2 3,5-DICAFFEOYL-QUINIC-ACID 1 3,5-DIHYDROXY-4-METHOXYBENZOIC-ACID-METHYL-ESTER 1 3,5-DIMETHOXY-1,6-DIHYDROXYXANTHONE 1 3,5-DIMETHYL-4,6-DI-O-METHYLPHLOROACETOPHENONE 1 3,7,8,2',5'-PENTAHYDROXYFLAVONE 1 3-(3,3-DIMETHYLALLYL)-5-(3-ACETYL-2,4-DIHYDROXY-5-METHYL-6-METHOXYBENZYL)- 2 PHLORACETOPHENONE 3-ACETYLACONITINE 5 3-BETA-23,28-TRIHYDROXY-12-OLEANENE-23-CAFFEATE 2 6 Chemical Activity Count 3-BETA-23,28-TRIHYDROXY-12-OLEANENE-3-BETA-CAFFEATE 2 3-BETA-ACETOXY-20,25-EPOXYDAMMARANE-24-OL 1 3-BETA-HYDROXY-2,3-DIHYDROWITHANOLIDE-F 1 3-BETA-TRANS-(3,4-DIHYDROXYCINNAMOYLOXY)-20(29)-LUPEN-28-OIC-ACID 1 3-BETA-TRANS-(3,4-DIHYDROXYCINNAMOYLOXY)-OLEAN-12-EN-28-OIC-ACID 1 3-BETA-TRANS-(3,4-DIHYDROXYCINNAMOYLOXY)-OLEAN-18-EN-28-OIC-ACID 1 3-BUTENYL-ISOTHIOCYANATE 1 3-CARBOMETHOXY-1,8-DIHYDROXYANTHRAQUINONE 1 3-DEHYDRONOBILIN 1 3-DESMETHYLCOLCHICINE 1 3-EPIBERCILLOGENIN 1 3-HYDROXY-FLAVONE 3 3-HYDROXYDAMSIN 1 3-INDOLEMETHANOL 1 3-METHOXY-1,8-DIHYDROXY-ANTHRQUINONE 1 3-N-BUTYL-PHTHALIDE 3 3-O-ACETYLOLEANOLIC-ACID 1 3-O-BENZOYL-URSOLIC-ACID 1 3-O-CAFFEOYLQUINIC-ACID 1 3-O-CINNAMOYL-URSOLIC-ACID 1 3-O-CROTONYL-URSOLIC-ACID 1 3-O-METHYL-MANGOSTIN 1 3-O-PALMITOYL-URSOLIC-ACID 1 3-O-PROPIONYL-URSOLIC-ACID 1 3-OXO-11-ALPHA-HYDROXYOLEAN-12-ENE-30-OIC-ACID 2 3-OXO-11-ALPHA-METHOXYOLEAN-12-ENE-30-OIC-ACID 2 3-OXO-OLEAN-9(11),12-DIENE-30-OIC-ACID 2 7 Chemical Activity Count 4',5,6,7,8-PENTAMETHOXY-FLAVONE 1 4'-DEMETHYLDEOXYPODOPHYLLUM 1 4'-DEMETHYLPODOPHYLLUM 1 4'-HYDROXY-FLAVONE 1 4,15-DIHYDROVERNODALIN 2 4,4'-DIALLYL-2,3'-DIHYDROXYBIPHENYL 1 4,4'-DIALLYL-2,3'-DIHYDROXYBIPHENYL-ETHER 1 4,5-DI-O-CAFFEOYLQUINIC-ACID 1 4,5-DIHYDROVERNODALIN 2 4,5-DIMETHOXY-6-(2-PROPENYL)1,3-BENZDIOXOLE 1 4,6-BENZYLIDENE-D-GLUCOSE 1 4,7-DIHYDROXY-2-METHOXY-9,10-DIHYDROPHENANTHRENE 1 4,8'-BISCATECHIN 1 4,8-HYDROXYWITHANOLINE-E 1 4-(3,4-DIHYDROXY-BENZOYL-OXY-METHYL)-PHENYL-BETA-D-GLUCOPYRANOSIDE 1 4-ACETYLARABINOSYL-ELLAGIC-ACID 1 4-ACETYLXYLOSYL-ELLAGIC-ACID 1 4-ALLYL-PYROCATECHOL 1 4-AMINO-1,2-NAPTHOQUINONE 2 4-AMINO-4-CARBOXYCHROMAN-2-ONE 1 4-ARABINOSYL-ELLAGIC-ACID 1 4-BETA-HYDROXYWITHANOLIDE 1 4-EPIABIETIC-ACID 1 4-EPIABIETOL 1 4-HYDROXY-3(3-METHYL-2-BUTENYL)BENZOIC-ACID-METHYL-ESTER 1 4-HYDROXY-3,5-BIS(3-METHYL-2-BUTENYL)-BENZOIC-ACID 1 4-HYDROXY-3,5-BIS(3-METHYL-2-BUTENYL)BENZOIC-ACID-METHYL-ESTER 1 8 Chemical Activity Count 4-HYDROXY-3-(3-METHYL-2-BUTENYL)-5-(3-METHYL-2-BUTENYL)-BENZOIC-ACID 1 4-HYDROXY-3-(ISOPENTEN-2-YL)-ACETOPHENONE 1 4-HYDROXY-TRITRIACONTANE-16,18-DIONE 1 4-HYDROXYBENZALDEHYDE 1 4-HYDROXYBENZOYL-ERYTHRITOL 1 4-HYDROXYCINNAMIC-ACID 1 4-HYDROXYCOUMARIN 1 4-KETOPINORESINOL 1 4-METHOXY-3,5-BIS(3-METHYL-2-BUTENYL)BENZOIC-ACID 1 4-METHYLTHIOCANTHIN-6-ONE 1 4-O-CAFFEOYLQUINIC-ACID 1 4-O-METHYL-GLUCURONOXYLAN 1 4-PENTENYL-ISOTHIOCYANATE 1 4-TERPINEOL 1 4-VINYL-GUAIACOL 2 5'-DEMETHOXYDEOXYPODOPHYLLUM 1 5'-DESMETHOXY-BETA-PELTATIN-METHYL-ETHER 1 5,6-DEHYDROKAWAIN 1 5,7,2',6'-TETRAHYDROXYFLAVONE 1 5,7,4'-TRIHYDROXY-6,8-DIPRENYLISOFLAVONE 1 5,7-DIHYDROXY-2-METHYLCHROMONE-8-C-BETA-GLUCOPYRANOSIDE 2 5,7-DIHYDROXY-3,8-DIMETHOXYFLAVONE 1 5,7-DIHYDROXY-8-METHOXY-2-METHYLCROMONE 1 5,7-DIHYDROXY-FLAVONE 1 5,7-DIHYDROXYCHROMONE 1 5,7-DIHYDROXYCOUMARIN-7-METHYL-ETHER 1 5,7-DIMETHOXYFLAVONE 1 9 Chemical Activity Count 5,8-DIHYDROXYBENZOPYRANONE 1 5-BETA-HYDROXYECDYSTERONE 1 5-DEOXYINGENOL-ESTER 1 5-HEXYL-CYCLOPENTA-1,3-DIONE 1 5-HYDROXY-3',4,6',7,8-PENTAMETHOXYFLAVONE 1 5-HYDROXY-7,4-DIMETHOXYFLAVONE 1 5-HYDROXY-8-O-BETA-D-GLUCOPYRANOSYL-BENZOPYRANONE 1 5-HYDROXY-FLAVONE 1 5-HYDROXYTRYPTAMINE 1 5-METHOXY-PSORALEN 3 5-METHOXYCANTHIN-6-ONE 1 5-O-BETA-D-GLUCOPYRANOSYL-3-1-(4-PHENYL)-DECANE 1 5-O-CAFFEOYLQUINIC-ACID 1 5-OCTYL-CYCLOPENTA-1,3-DIONE 1 6'-O-ACETYL-DAIDZIN 1 6'-O-ACETYL-GENISTIN 1 6,7,4'-TRIHYDROXYISOFLAVAN 1 6,7,4'-TRIHYDROXYISOFLAVANONE 1 6,7,4'-TRIHYDROXYISOFLAVONE 1 6,7-DI-4'-METHOXYISOFLAVAN 1 6,7-DI-4'-METHOXYISOFLAVANONE 1 6,7-DI-4'-METHOXYISOFLAVONE 1 6,7-DIHYDROXY-4'-METHOXYISOFLAVAN 1 6,7-DIHYDROXY-4'-METHOXYISOFLAVANONE 1 6,7-DIHYDROXY-4'-METHOXYISOFLAVONE 1 6,7-DIHYDROXYCOUMARIN 1 6,7-DIMETHOXYCOUMARIN 1 10 Chemical Activity Count 6,7-DIMETHYLAESCULETIN 2 6,7-DIMETHYLESCULETIN 2 6-ALPHA-HYDROXYDEHYDROCOSTUS-LACTONE 1 6-ALPHA-HYDROXYMEDICARPIN 1 6-ALPHA-SENECIOLOXYCHAPARRINONE 1 6-DEHYDROGINGERDIONE 1 6-DEOXYJACAREUBIN 2 6-ETHOXYCHELERYTHRINE 1 6-GINGERDIOL 1 6-GINGERDIONE 1 6-GINGEROL 4 6-HYDROXY-FLAVONE 1 6-HYDROXY-FLAVONE-GLUCOSIDE 1 6-METHOXYTECLEANTHINE 1 6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE 2 6-O-(2''-ACETYL-3'',4''-O-DI-P-METHOXYCINNAMOYL-ALPHA-L-RHAMNOPYRANOSYL)-CATALPOL 1 6-O-(4''-ACETYL-2'',3''-O-DI-P-METHOXYCINNAMOYL-ALPHA-L-RHAMNOPYRANOSYL)-CATALPOL 1 6-SHOGAOL 3 7,4'-DIHYDROXY-8-METHYLFLAVAN 1 7,4'-DIHYDROXYFLAVAN 1 7,8-DIHYDROXYFLAVONE 3 7-HYDROXY-6-HYDROMELODIENOL 2 7-HYDROXY-FLAVONE 1 7-HYDROXY-FLAVONE-GLUCOSIDE 1 7-HYDROXYFLAVAN 1 7-HYDROXYFRULLANOLIDE 1 7-METHOXYCOUMARIN 2 11 Chemical Activity Count 7-METHYL-ERIODICTYOL-ETHER 1 7-N-BUTOXY-3,2',5'-TRIHYDROXYFLAVONE 1 7-O-(6-O-BETA-D-APIOFURANOSYL)-BETA-D-(GLUCOPYRANOSYL)-ORCHINOL 1 7-O-METHYL-GLABRANINE 1 7-[3-(3,4-DIHYDROXY-4-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YLOXY)-4,5-DIHYDROXY-6- 1 HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY]...
Recommended publications
  • Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Lyme Disease (Chronic)
    Dr.
    [Show full text]
  • Supporting Materials for Reappointment of Rong Di for 2004
    CURRICULUM VITAE Rong Di Associate Research Professor Department of Plant Biology School of Environmental and Biological Sciences Rutgers University 222B Foran Hall, 59 Dudley Rd., New Brunswick, NJ 08901 Ph. (848)-932-6350, Fax (732)-932-9377 [email protected] http://plantbiology.rutgers.edu/faculty/di/Rong_Di.html July 2017 Appointments 2017-Present Associate Research Professor, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 2011-2017 Assistant Research Professor, Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 2014-Present Adjunct Professor, Hainan University, Hainan, China 2003-2011 Assistant Research Professor, Biotechnology Center for Agriculture and the Environment, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 1997- 2002 Research Associate, Biotechnology Center for Agriculture and the Environment, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 1992-1996 Postdoctoral Scholar, Dept. of Plant Pathology, and Dept. of Agronomy, University of Kentucky, Lexington, KY 1986-1992 Graduate Research Assistant, Dept. of Plant Pathology, Iowa State University, Ames, IA 1983-1985 Assistant Lecturer, Dept. of Plant Protection, South China College of Tropical Crops (SCCTC), Hainan, P. R. China Education Ph.D. 1992 Plant Virology, Iowa State University, Iowa (Advisor: W Allen Miller) M.S. 1989 Plant Virology, Iowa State University, Iowa (Advisor: John Hill) B.S. 1983 Plant Protection, South China College of Tropical Crops, Hainan, P.R. China Honors and Awards 1985 Selected as the only one among 45 graduates in the Dept. of Plant Protection from SCCTC China to study abroad.
    [Show full text]
  • Chemoprotective Effects of Flaxseed Lignans Enterodiol And
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Texas A&M Repository CHEMOPROTECTIVE EFFECTS OF FLAXSEED LIGNANS ENTERODIOL AND ENTEROLACTONE IN NON-TRANSFORMED COLONOCYTES A Thesis by CHRISTINA ALISON CURRY Submitted to the Office of Graduate and Professional Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Chair of Committee, Clinton Allred Committee Members, Joseph Awika Jenna Anding Head of Department, Boon Chew December 2015 Major Subject: Nutrition Copyright 2015 Christina Alison Curry ABSTRACT Previous epidemiological studies have shown that colon cancer incidence is correlated to diet and estrogen status. Phytoestrogens are molecules with similar structures to estrogen that occur naturally in plants. There is in vitro and in vivo evidence that phytoestrogens in the diet can inhibit carcinogenesis. The phytoestrogenic mammalian lignans enterolactone (EL) and enterodiol (ED) in flaxseed have been shown to be effective in decreasing tumor incidence in carcinogenic models, but there is little data regarding their effects in non-malignant cells. The following studies used a non- transformed cell line of young adult mouse colonocytes (YAMC) to determine the protective effects of ED and EL in chemoprevention. Our results demonstrate that low levels of EL (1µM) and ED (5µM) are effective at significantly reducing cell growth and increasing apoptosis. These treatments also regulated transcription via significant differences in gene levels related to apoptosis and cell cycle progression. The data collected demonstrate some of the physiological effects of EL and ED on the cellular and molecular level.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. N0.: US 2014/0221426 A1 Gerk Et Al
    US 20140221426A1 (19) United States (12) Patent Application Publication (10) Pub. N0.: US 2014/0221426 A1 Gerk et al. (43) Pub. Date: Aug. 7, 2014 (54) SELECTIVE METABOLIC APPROACH TO A61K 31/216 (2006.01) INCREASING ORAL BIOAVAILABILITY OF A61K 31/09 (2006.01) PHENYLEPHRINE AND OTHER PHENOLIC A61K 31/05 (2006.01) BIOACTIVITIES A61K 31/353 (2006.01) A61K 31/4525 (2006.01) (71) Applicant: VIRGINIA COMMONWEALTH A61 K 31/3 75 (2006.01) UNIVERSITY, Richmond, VA (US) A61K 31/121 (2006.01) _ _ _ (52) US. Cl. (72) Inventorsl Ph_lll_lP M- Gerk’ Rthmond, VA (Us); CPC ........... .. A61K 31/137 (2013.01); A61K 31/3 75 Wllllam H- Fa", R10hm°nda VA (Us); (2013.01); A61K 31/235 (2013.01); A61K J"sellh K- thter’ Rlchmond, VA (Us) 31/11 (2013.01); A61K 31/085 (2013.01); _ A61K 31/121 (2013.01); A61K 31/09 (21) APP1~ NO" 14/345,689 (2013.01); A61K31/05 (2013.01); A61K . _ 31/353 (2013.01);A61K31/4525 (2013.01); (22) PCT Filed. Sep. 27, 2012 A61K31/216 (201301) USPC ......... .. 514/321' 514/653' 514/474' 514/544' ( 86 ) PCT N 0 .: PCT/U52012/057588 ’ ’ 514/456;’ 514/532’ § 371 (0X1), Related US“ Application Data Presystemic metabolism in intestine of bioactives such as (60) Provisional application No. 61/539,530, ?led on Sep. phenylephrine 1? avoided by administering a Sllbject (human 27, 2011, provisional application No. 61/544,396, 0r 21111111211) the bloactlve(e-g-,Pheny1ephr1ne)1n comblnatlon ?led on Oct 7, 201 1_ With one or more inhibitors of sulfation (e.g., sulfotransferase enzymes aka SULTs).
    [Show full text]
  • Selective Estrogen Receptor Modulators for BPH: New Factors on the Ground
    Prostate Cancer and Prostatic Disease (2013) 16, 226–232 & 2013 Macmillan Publishers Limited All rights reserved 1365-7852/13 www.nature.com/pcan REVIEW Selective estrogen receptor modulators for BPH: new factors on the ground M Garg1, D Dalela1, D Dalela1, A Goel1, M Kumar1, G Gupta2 and SN Sankhwar1 As the current management of BPH/lower urinary tract symptoms by traditionally involved pharmacological agents such as 5alpha- reductase inhibitors and a1-adrenoceptor antagonists is suboptimal, there is definite need of new therapeutic strategies. There is ample evidence in literature that suggests the role of estrogens in BPH development and management through the different tissue and cell-specific receptors. This article reviews the beneficial actions of selective estrogen receptor modulator (SERM) and ERb- selective ligands, which have been demonstrated through in vitro studies using human prostate cell lines and in vivo animal studies. SERMs have anti-proliferative, anti-inflammatory and pro-apoptotic mechanisms in BPH, and also act by inhibiting various growth factors, and thus represent a unique and novel approach in BPH management directed at estrogen receptors or estrogen metabolism. Prostate Cancer and Prostatic Disease (2013) 16, 226–232; doi:10.1038/pcan.2013.17; published online 18 June 2013 Keywords: selective estrogen receptors modulators; BPH; estradiol; estrogen receptor b INTRODUCTION relevant articles were selected for the discussion of role of SERMs in BPH in BPH is a common urological problem of aging males. It occurs in this review. about 10% of men below the age of 40 and increases to about 80% by 80 years of age.1 Clinical BPH is a benign enlargement of the prostate, which ESTROGENS AND ITS RECEPTORS: ROLE IN BPH results in voiding urinary difficulties that may, sometimes, Though BPH typically manifests in later stage of life when 2 significantly impair the quality of life in older patients.
    [Show full text]
  • Comparative Studies of Corrosion Inhibitive Properties of Benzofuran
    ISSN (Online) 2456-1290 International Journal of Engineering Research in Mechanical and Civil Engineering (IJERMCE) Vol 2, Issue 11,November 2017 Comparative studies of Corrosion Inhibitive Properties of Benzofuran-2-carboxylic acid & Amla Leaves Extract On Mild Steel in Acid Media [1] Abhishek Kumar, [2] Ankit Aggarwal, [3] Ashutosh Krishna Piyush, [4] Abhishek Kumar, [5] Aatiq ShafiqDar, [6] Angel Roy, [7] Dr Hari Krishna S [1][2][3][6] 1st Year Department Of Computer Science & Engineering, Sri SaiRam College Of Engineering, Bangalore, [4] 1st Year Department of Electrical & Electronics, Sri SaiRam College Of Engineering, Bangalore [5] 1st Year Department Of Mechanical Engineering, Sri SaiRam College Of Engineering, Bangalore [7] Assistant Professor, Department Of Chemistry, Sri SaiRam College Of Engineering, Bangalore Abstract:- The effects of Benzofuran-2-carboxylic acid (BF) & Amla (Emblica officinal is) leaves aqueous extract as a corrosion inhibitor, behaviour of mild steel has been investigated in hydrochloric acid solutions containing Experiments were performed by weight loss method for different time intervals and at room temperature. The inhibition efficiency of Benzofuran-2-carboxylic acid was found to increase with inhibitor concentration and also in the presence of sodium bromide and sodium iodide. Inhibition efficiency was found to increase with increasing concentration of inhibitor (0.2 g /l to 10 g/l) for 6 hours at room temperature. The maximum inhibition efficiency of Emblica officinal is leaving 87 % in 1 N Hydrochloric acid. From the comparative studies, it was investigated that the corrosion inhibition efficiency of Emblica officinal is leaving as aqueous extract is approximately equal to that of Benzofuran-2-carboxylic acid in hydrochloric acid.
    [Show full text]
  • Guava (Psidium Guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities
    foods Review Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities Manoj Kumar 1 , Maharishi Tomar 2, Ryszard Amarowicz 3,* , Vivek Saurabh 4 , M. Sneha Nair 5, Chirag Maheshwari 6, Minnu Sasi 7, Uma Prajapati 4, Muzaffar Hasan 8, Surinder Singh 9, Sushil Changan 10 , Rakesh Kumar Prajapat 11, Mukesh K. Berwal 12 and Varsha Satankar 13 1 Chemical and Biochemical Processing Division, ICAR—Central Institute for Research on Cotton Technology, Mumbai 400019, India; [email protected] 2 ICAR—Indian Grassland and Fodder Research Institute, Jhansi 284003, India; [email protected] 3 Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Str., 10-748 Olsztyn, Poland 4 Division of Food Science and Postharvest Technology, ICAR—Indian Agricultural Research Institute, New Delhi 110012, India; [email protected] (V.S.); [email protected] (U.P.) 5 Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad 121004, Haryana, India; [email protected] 6 Department of Agriculture Energy and Power, ICAR—Central Institute of Agricultural Engineering, Bhopal 462038, India; [email protected] 7 Division of Biochemistry, ICAR—Indian Agricultural Research Institute, New Delhi 110012, India; [email protected] 8 Agro Produce Processing Division, ICAR—Central Institute of Agricultural Engineering, Citation: Kumar, M.; Tomar, M.; Bhopal 462038, India; [email protected] 9 Amarowicz, R.; Saurabh, V.; Nair, Dr. S.S. Bhatnagar University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, India; [email protected] M.S.; Maheshwari, C.; Sasi, M.; 10 Division of Crop Physiology, Biochemistry and Post-Harvest Technology, ICAR—Central Potato Research Prajapati, U.; Hasan, M.; Singh, S.; Institute, Shimla 171001, India; [email protected] et al.
    [Show full text]
  • Phytopharmacological Overview of Psidium Guajava Linn
    Pharmacogn. J. Review Article A multifaceted peer reviewed journal in the field of Pharmacognosy and Natural Products www.phcogfirst.com/phcogj Phytopharmacological overview of Psidium guajava Linn. Vijaya Anand1, Manikandan2, Vijaya Kumar2, Sampath Kumar3, Pushpa4, Agaath Hedina1 1Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore–641 046, Tamil Nadu, INDIA. 2Department of Biochemistry, M.I.E.T. Arts and Science College, Tiruchirappalli–620 007, Tamil Nadu, INDIA. 3Department of Chemistry and Biosciences, SASTRA University, Kumbakonam–612 001, Tamil Nadu, INDIA. 4Department of Microbiology, Cauvery College for Women, Tiruchirappalli–620 018, Tamil Nadu, INDIA. ABSTRACT Psidium guajava Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as pheno- Corresponding author: lic, flavonoid and carotenoid. Numerous pharmacological investigation have Dr. A. Vijaya Anand, confirmed that the ability of this plant is to exhibit antimicrobial, antidia- Associate Professor and Head, Department of Human Genetics and betic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and Molecular Biology, Bharathiar University, Coimbatore–641 046, anticancer activities and it supports the traditional uses. This is a compre- Tamil Nadu, INDIA. hensive of the phytoconstituents and pharmacological benefits. Mobile: +91 9842525830 Key words: Psidium guajava, Antimicrobial, Antidiabetic, Antioxidant, Hep- E-mail: [email protected] atoprotective, Anticancer. DOI: 10.5530/pj.2016.4.3 INTRODUCTION (9Z)-, (13Z)-, and (15Z)-lycopene, (all-E,3R)-beta-cryptoxanthin, (all- E, 3R)-rubixanthin, (all-E,3S,5R,8S)-cryptoflavin, (all-E,3R,3’R, 6’R)- Psidium guajava Linn. is commonly called guave, goyave in French; lutein, (all-E,3S,5R,6R,3’S,5’R,8’R)-, and (all-E,3S,5R,6R,3’S, 5’R,8’S)- guave, guavenbaum, in German; banjiro in Japanese; goiaba, in Portu- neochrome.9 Guavanoic acid, guavacoumaric acid, 2α-hydroxyursolic 1 gal; arac¸ guaiaba in Brazil; and guava in English.
    [Show full text]
  • Phytoestrogens : Daidzein, Enterodiol, Enterolactone, Equol, Geinstein, O-Desmethylangolensin Matrix: Urine Method: HPLC-ESI-MS/MS Method No: 4069.03
    Laboratory Procedure Manual Analyte: Phytoestrogens : Daidzein, Enterodiol, Enterolactone, Equol, Geinstein, O-Desmethylangolensin Matrix: Urine Method: HPLC-ESI-MS/MS Method No: 4069.03 Revised: March 2018 as performed by: Nutritional Biomarkers Branch (NBB) Division of Laboratory Sciences (DLS) National Center for Environmental Health (NCEH) contact: James L. Pirkle, M.D., Ph.D. Director, Division of Laboratory Sciences Important Information for Users CDC periodically refines these laboratory methods. It is the responsibility of the user to contact the person listed on the title page of each write-up before using the analytical method to find out whether any changes have been made and what revisions, if any, have been incorporated. Phytoestrogen NHANES 2013-2014 This document details the Lab Protocol for testing the items listed in the following table. This method file describes measurements of U1PHYTO_H_R and U2PHYTO_H_R. One method was used to measure both the 24 hour urine phytoestrogen, 1st urine collection and 24 hour urine phytoestrogen, 2nd urine collection. However, these results are released as 2 separate data files. Variable File Name SAS Label (and SI units) Name Daidzein, Urine 1st collection UR1DAZ (ng/mL) o-Desmethylangolensin, Urine 1st UR1DMA Collection (ng/mL) UR1EQU Equol, Urine 1st Collection (ng/mL) Enterodiol, Urine 1st Collection UR1ETD (ng/mL) Enterolactone, Urine 1st Collection UR1ETL (ng/mL) Genistein, Urine 1st Collection UR1GNS (ng/mL) U1PT_H_R Daidzein, Urine 2nd collection U2PT_H_R UR2DAZ (ng/mL) o-Desmethylangolensin, Urine 2nd UR2DMA Collection (ng/mL) UR2EQU Equol, Urine 2nd Collection (ng/mL) Enterodiol, Urine 2nd Collection UR2ETD (ng/mL) Enterolactone, Urine 2nd Collection UR2ETL (ng/mL) Genistein, Urine 2nd Collection UR2GNS (ng/mL) 2 of 54 Phytoestrogen NHANES 2013-2014 1.
    [Show full text]
  • Medicinal Properties of Selected Asparagus Species: a Review Polo-Ma-Abiele Hildah Mfengwana and Samson Sitheni Mashele
    Chapter Medicinal Properties of Selected Asparagus Species: A Review Polo-Ma-Abiele Hildah Mfengwana and Samson Sitheni Mashele Abstract Asparagus species are naturally distributed along Asia, Africa, and Europe and are known to have numerous biological properties. This review article was aimed to provide an organized summary of current studies on the traditional uses, phy- tochemistry, and pharmacological and toxicological studies of Asparagus laricinus Burch., Asparagus africanus Lam., Asparagus officinalis L., Asparagus racemosus Willd., and Asparagus densiflorus (Kunth) Jessop to attain and establish new insights for further researches. Information used in this review was obtained from electronic database including PubMed central, Google scholars, Science direct, Scopus, and Sabinet. Based on the present findings, the existing literature still presents some breaches about the mechanism of action of various constituents of these plants, and their relation to other plant compounds in poly-herbal formulations, as well as their long-term use and safety. More in-depth studies are still needed for active compounds and biological activities of Asparagus laricinus, Asparagus africanus, and Asparagus densiflorus. Therefore, innumerable opportunities and possibilities for investigation are still available in novel areas of these plants for future research stud¬ies. It can be concluded that all selected Asparagus species have tremendous potential to improve human health and the pharmacological activities of these plants can be attributed to bioactive phytochemicals they possess. Keywords: Asparagaceae, Asparagus africanus lam., Asparagus densiflorus (kunth) Jessop, Asparagus laricinus Burch., Asparagus officinalis L., Asparagus racemosus Willd., pharmacological actions, phytochemistry 1. Introduction Historically, plants were used for numerous purposes for mankind in general, inter alia, feeding and catering, culinary spices, medicine, various forms of cosmetics, symbols in worship and for a variety of ornamental goods.
    [Show full text]
  • The Phytochemistry of Cherokee Aromatic Medicinal Plants
    medicines Review The Phytochemistry of Cherokee Aromatic Medicinal Plants William N. Setzer 1,2 1 Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]; Tel.: +1-256-824-6519 2 Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA Received: 25 October 2018; Accepted: 8 November 2018; Published: 12 November 2018 Abstract: Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines. Keywords: Cherokee; Native American; traditional herbal medicine; chemical constituents; pharmacology 1. Introduction Natural products have been an important source of medicinal agents throughout history and modern medicine continues to rely on traditional knowledge for treatment of human maladies [1]. Traditional medicines such as Traditional Chinese Medicine [2], Ayurvedic [3], and medicinal plants from Latin America [4] have proven to be rich resources of biologically active compounds and potential new drugs.
    [Show full text]
  • In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: a Case of Padma Hepatenr Formulation
    Article In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepatenr Formulation Daniil N. Olennikov 1,*, Nina I. Kashchenko 1,: and Nadezhda K. Chirikova 2,: Received: 28 August 2015 ; Accepted: 30 September 2015 ; Published: 13 October 2015 1 Laboratory of Medical and Biological Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, Sakh’yanovoy Street 6, Ulan-Ude 670-047, Russia; [email protected] 2 Department of Biochemistry and Biotechnology, North-Eastern Federal University, 58 Belinsky Street, Yakutsk 677-027, Russian; [email protected] * Correspondence: [email protected]; Tel.: +7-9021-600-627; Fax: +7-3012-434-243 : These authors contributed equally to this work. Abstract: Chebulic ellagitannins (ChET) are plant-derived polyphenols containing chebulic acid subunits, possessing a wide spectrum of biological activities that might contribute to health benefits in humans. The herbal formulation Padma Hepaten containing ChETs as the main phenolics, is used as a hepatoprotective remedy. In the present study, an in vitro dynamic model simulating gastrointestinal digestion, including dialysability, was applied to estimate the bioaccessibility of the main phenolics of Padma Hepaten. Results indicated that phenolic release was mainly achieved during the gastric phase (recovery 59.38%–97.04%), with a slight further release during intestinal digestion. Dialysis experiments showed that dialysable phenolics were 64.11% and 22.93%–26.05% of their native concentrations, respectively, for gallic acid/simple gallate esters and ellagitanins/ellagic acid, in contrast to 20.67% and 28.37%–55.35% for the same groups in the non-dialyzed part of the intestinal media.
    [Show full text]