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Download the Program and Abstract Book SETAC North America Focused Topic Meeting High-Throughput Screening and Environmental Risk Assessment STATE OF THE SCIENCE AND EMERGING APPLICATIONS Meeting Program All meetings will be held in Grand Ballroom 1-2. Coffee breaks and poster socials will be held in Grand Ballroom 3. Monday, 16 April High-Throughput Screening and Ecological Risk Assessment – Background and Setting the Stage Time Title Speakers 7:45 a.m.–8:30 a.m. Registration in the Ballroom Foyer 8:30 a.m.–8:35 a.m. Welcome and Logistics Tamar Schlekat 8:35 a.m.–8:40 a.m. Meeting Overview Natalia Vinas Dan Villeneuve Introduction to Environmental Risk Assessment and High-Throughput Screening Session Chair: Natalia Vinas 8:40 a.m.–9:10 a.m. Fundamentals of Environmental Risk Assessment Jane Staveley 9:10 a.m.–9:40 a.m. A National Strategy to Modernize Safety Testing Nicole Kleinstreuer 9:40 a.m.–10:10 a.m. Accelerating the Development and Use of High-Throughput Screening Data for Rusty Thomas Application to Regulatory Risk Assessments 10:10 a.m.–10:40 a.m. Coffee Break 10:40 a.m.–11:10 a.m. HTPS In Vitro Human Cell-based Toxicity Screening of Compounds and Peter Behnisch Water Samples 11:10 a.m.–11:40 a.m. Looking for Data in All the (Sometimes) Right Places, from Experts to Shannon Bell Machines and the Databases in Between 11:40 a.m.–12:10 p.m. In Silico Approaches for Predicting Hazards from Chemical Structure and Lyle Burgoon Existing Data 12:10 p.m.–1:20 p.m. Lunch (on your own) Challenges to the Use of Mechanistic and In Vitro Data in Environmental Risk Assessment – Emerging Solutions Session Chair: Ellen Mihaich 1:20 p.m.–1:50 p.m. Historical and Perceived Limitations to the Use of Mechanistic Data in Valery Forbes Environmental Risk Assessment 1:50 p.m.–3:00 p.m. Diversity of Risk Assessment Context and Problems – Challenges Faced and Jane Staveley Perspectives on the Potential Role for High-Throughput Screening Cheryl Murphy Mark Jankowski Daniel Chang 3:00 p.m.–3:30 p.m Coffee Break 3:30 p.m.–3:50 p.m. Linking Mechanistic Data to Endpoints of Regulatory Concern Using the Dan Villeneuve Adverse Outcome Pathway Framework 3:50 p.m.–4:20 p.m. Translating In Vitro Effect Concentrations to In Vivo Dose and Environmental Nynke Kramer Exposure Concentrations 4:20 p.m.–4:45 p.m. Challenges in Extrapolating from Lab to Field and from Individuals to Valery Forbes Populations and Ecosystems Story Problems Session Chair: Ellen Mihaich 4:45 p.m.–5:30 p.m. The Practical Use of High-Throughput Data to Solve Real-World Risk Ellen Mihaich Assessment Challenges: A Story Problem Approach Katie Coady Beate Escher 5:30 p.m.–7:00 p.m. Poster Social hts.setac.org SETAC North America Focused Topic Meeting Tuesday, 17 April Data and Tools Using the ToxCast and Tox21 Data Session Chair: Dan Villeneuve Time Title Speakers 8:30 a.m.–9:00 a.m. The USEPA Comptox Chemistry Dashboard: A Wed-based Data Integration Antony Williams Hub for Environmental Chemistry and Toxicology Data 9:00 a.m.–9:20 a.m. The ToxCast Data Pipeline: Purpose, Structure, On-Going Improvements Katie Paul-Friedman and Example 9:20 a.m.–9:40 a.m. Development and Distribution of Test Method Documentation for ToxCast Katie Paul-Friedman High-Throughout Testing Assays Stacie Flood 9:40 a.m.–10:20 a.m. Understanding the Biology and Technology of ToxCast and Tox21 Assays Keith Houck 10:20 a.m.–10:50 a.m. Coffee Break 10:50 a.m.–11:15 a.m. In Vitro Chemical Screening Assays to Identify Thyroid Hormone Distruptors Michael Hornung 11:15 a.m.–11:35 a.m. Considerations for Developing and Implementing Performance-based Steven Levine Validation Approaches to Support ToxCast Assays Intro to Complementary Tools Session Chair: Cheryl Murphy 11:40 a.m.–12:00 p.m. Defining the Taxonomic Domain of Applicability for Mammalian-based High Dan Villeneuve Throughput Screening Assays 12:00 p.m.–12:15 p.m. Linking High-Throughput Screening Assay Responses to Potential Hazards and Stephen Edwards Adverse Effects – Adverse Outcome Pathway Knowledge Base 12:15 p.m.–12:30 p.m. Incorporating Sub-Organismal Processes that Occur at the Molecular and Cheryl Murphy Cellular Level to Dynamic Energy Budgets to Determine Whole Organism Responses Lunch Networking Bring your lunch and join us for mingling with genius bar exhibitors who will demonstrate tools that 12:30 p.m.–2:30 p.m. address the story problems Individual Chemical Assessments Session Chair: Katie Coady 2:30 p.m.–2:55 p.m. What Needs to Be True? An Industry Perspective on Incorporating Kristen Connors High-Throughput Screening Data in Environmental Risk Assessments 2:55 p.m.–3:20 p.m. In Vitro Screening and Integrated Approaches for Testing and Assessment: An Katie Coady Industry Perspective 3:20 p.m.–3:50 p.m. Coffee Break 3:50 p.m.–4:15 p.m. Adverse-Outcome-Pathway–Informed Chemical Screening, Prioritization and Knut Erik Tollefsen Risk Assessment of Arthropod Endocrine Disruptors 4:15 p.m.–4:40 p.m. Case Study: High-Throughput Screening Applied to Hazard and Effects Dan Chang Assessment for Environmental Risk Assessment 4:40 p.m.–5:30 p.m. Brainstorming of Additional Applications, Research Needs and Questions and Follow-Up 5:30 p.m.–7:00 p.m. Poster Social Enjoy complimentary free Wi-Fi during the meeting! Username: DCCGuest Password: globalhyd hts.setac.org SETAC North America Focused Topic Meeting Wednesday, 18 April Application Case Studies – Environmental Monitoring and Complex Mixtures HTS Data in Risk-Based Prioritization of Environmental Samples Session Chair: Dan Villeneuve Time Title Speakers 8:30 a.m.–9:00 a.m. Application of Exposure: Activity Rations from High-Throughput Screening to Steve Corsi Evaluate Potential Biological Effects From Trace Organic Chemicals 9:00 a.m.–9:20 a.m. Using High-Throughput Approaches to Assess Effectiveness of Wastewater Dalma Martinovic- and Stormwater Treatment Weigelt 9:20 a.m.–9:45 a.m. Pilot Testing Cell-based Receptor Assays to Screen for Emerging Contaminants Alvine Mehinto and Assess Risks in Aquatic Ecosystems 9:45 a.m.–10:15 a.m. Coffee Break Application of High-Throughput Screening Assays to Environmental Samples Session Chair: Beate Escher 10:15 a.m.–10:45 a.m. EU SOLUTIONS Project – Application of High-Throughput Screening for Water Henner Hollert Quality Monitoring and Effect-directed Analysis 10:45 a.m.–11:10 a.m. Evaluation of In Vitro Bioactivity of Surface Waters from a Nationwide Brett Blackwell Assessment of United States Streams 11:10 a.m.–11:35 a.m. In Vitro Bioassays for Monitoring of Wastewater Treatment Effluent Inge Werner 11:35 a.m.–12:00 p.m. Mixture Toxicity Modeling to Link Chemical Concentrations to High- Beate Escher Throughput Screening Data of Environmental Samples and for Deriving Effects-based Trigger Values 12:10 p.m.–1:20 p.m. Lunch (on your own) Story Problems Session Chair: Natalia Vinas 1:30 p.m.–3:30 p.m. Discuss Story Problems and Revisit Brainstorming and Research Needs Ellen Mihaich Katie Coady Beate Escher 3:30 p.m.–4:00 p.m. Closing Dan Villeneuve 4:00 p.m. Meeting Adjourns Volume 35 | Issue 3 | March 2016 ISSN 0730-7268 Publishing High-Impact Environmental High-Throughput Toxicology and Chemistry Screening Research Environmental surveillance and monitoring—The next frontiers for high- throughput toxicology hts.setac.org/frontiers hts.setac.org SETAC North America Focused Topic Meeting Thank you to the meeting supporters! SOCIETY OF ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY ENVIRONMENTAL QUALITY THROUGH SCIENCE® High-Throughput Screening and Environmental Risk Assessment STATE OF THE SCIENCE AND EMERGING APPLICATIONS Abstract Book SETAC North America Focused Topic Meeting 16–18 April 2018 Durham Convention Center Durham, NC, USA This book comprises the abstracts for the platform and poster presentations of the Society of Environmental Toxicology and Chemistry (SETAC) North America Focused Topic Meeting on “High-Throughput Screening and Environmental Risk Assessment: State of the Science and Emerging Applications,” which was held from 16–18 April 2018 at the Durham Convention Center in Durham, North Carolina. The abstracts are reproduced as accepted by the Scientific Program Committee and appear in numerical order. In each abstract, the presenting author’s name is underlined. No part of this publication may be reproduced, distributed, stored, or transmitted in any form or by any means, including photocopying, recording or other electronic or mechanical methods, without permission in writing from the copyright holder. All rights reserved. Authorization to photocopy items for internal or personal use, or for the purpose or internal use of specific clients, may be granted by SETAC, provided that the appropriate fee is paid directly to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923 USA (+1 978 750 8400) or to SETAC. Before photocopying items for educational classroom use, please contact the Copyright Clearance Center (www.copyright.com) or the SETAC Office in North America (+1 850 469 1500, [email protected]). SETAC’s consent does not extend to copying for general distribution, promotion, creating new works or resale. Specific permission must be obtained in writing from SETAC for such copying. Direct inquiries to SETAC, 229 South Baylen Street, 2nd Floor, Pensacola, FL 32502 USA. © 2018 Society of Environmental Toxicology and Chemistry (SETAC) International Standard Serial Number 1087-8939 About SETAC The Society of Environmental Toxicology and Chemistry (SETAC) is a not-for-profit, worldwide professional organization comprised of more than 5,100 individuals and institutions dedicated to the study, analysis and solution of environmental problems, the management and regulation of natural resources, environmental education, and research and development.
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