Supplementary Table 3A

IOP-GA IOP-GA IOP-PBS Public ID Gene Title Gene Symbol / IOP-PBS / N / N IOP Not Altered and GA Repressed cell adhesion-matrix / development / signal transduction & synaptic transmission BF401679 SWI/SNF related, matrix associated, actin dependent regulator of chromatin Smarca2 -1.31 -1.22 1.07 BI287851 procollagen, type VI, alpha 2 Col6a2_predicted -1.21 -1.12 1.08 AW253950 scavenger receptor class F, member 2 Scarf2_predicted -1.34 -1.48 -1.11 AA850264 similar to EHM2; erythrocyte membrane protein band 4.1 like 4B Epb41l4b_predicted -1.28 -1.18 1.09 AI013978 sushi, nidogen and EGF-like domains 1 Sned1 -1.28 -1.13 1.13 AA858928 growth hormone inducible transmembrane protein Ghitm -1.24 -1.17 1.06 AI713223 similar to protein phosphatase 1, regulatory subunit 12C Ppp1r13a_predicted -1.21 -1.12 1.08 AA800682 similar to DNA segment, Chr X, Immunex 38, expressed Wdr45_predicted -1.2 -1.15 1.05 BF391308 ephrin A5 /LOC302559Efna5 -1.58 -1.74 -1.1 AF080594 vascular endothelial growth factor A Vegfa -1.21 -1.14 1.06 BF395218 tropomyosin 1, a Tpm1 -1.32 -1.24 1.06 AI043907 ATPase, Ca+2-sequestering Atp2c1 -1.28 -1.23 1.04 BE113875 c-terminal PDZ domain ligand of neuronal nitric oxide synthase Capon; Nos1ap -1.24 -1.28 -1.03 BF409918 synaptotagmin 1 Syt1 -1.26 -1.4 -1.11 NM_017194 cholinergic receptor, nicotinic, epsilon polypeptide Chrne -1.2 -1.39 -1.15 L03202 5-hydroxytryptamine (serotonin) receptor 6 Htr6 -1.31 -1.42 -1.09 NM_133623 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 Slc6a13 -1.68 -1.34 1.25 BF406295 Discs, large homolog 2 (Drosophila) Dlgh2_predicted -1.47 -1.27 1.16 NM_021851 lin-7 homolog C (C. elegans) Lin7c_predicted -1.28 -1.17 1.09 immune response / cell proliferation AW142962 prolactin receptor Prlr -1.2 -1.1 1.1 AA997590 osteoglycin Ogn_predicted -1.28 -1.08 1.19 BE103520 insulin-like growth factor I mRNA, 3' end of mRNA Igf1 -1.29 -1.03 1.25 AF347936 IL-11, interleukin 11 receptor, a-chain 1 Il11ra1 -1.23 -1.06 1.16 BF391914 IL-1, interleukin 1 receptor accessory protein Il1rap -1.37 -1.39 -1.02 AI175479 intermediate in Toll pathway Sitpec /MGC94704 -1.23 -1.06 1.17 Cell cycle & apoptosis / transcription / cell signaling NM_012858 luteinizing hormone beta Lhb -1.33 -1.31 1.01 BF289778 shugoshin-like 2 (S. pombe) Sgol2_predicted -1.19 -1.1 1.08 BF416343 delangin ; Nipped-B homolog (Drosophila) Nipbl_predicted -1.26 -1.04 1.2 NM_012494 angiotensin II receptor, type 2 Agtr2 -1.29 -1.28 1 BI301178 Wolf-Hirschhorn syndrome candidate 1-like 1 Whsc1l1_predicted -1.31 -1.05 1.25 AI548915 similar to RIKEN cDNA G431002C21 RGD1307124_predicted -1.24 -1.28 -1.03 BE117138 nuclear factor I/X Nfix -1.28 -1.19 1.08 BE114154 similar to Mbt domain containing 1 Mbtd1 -1.33 -1.42 -1.07 BF412152 neuron navigator 1 Nav1_predicted -1.27 -1.26 1.01 BF552903 prickle-like 1 (Drosophila) Prickle1_predicted -1.31 -1.61 -1.24 AI555989 USP6 N-terminal like Usp6nl_predicted -1.3 -1.15 1.14 AF024622 guanylate cyclase 2g Gucy2g -1.28 -1.33 -1.04 BI294556 serine/threonine kinase 17b (apoptosis-inducing) Stk17b -1.22 -1.18 1.03 AI070366 similar to transmembrane serine protease 9 Tmprss9_predicted -2.8 -1.96 1.43 AB023634 protein phosphatase 1F (PP2C domain containing) /LOC363274Ppm1f -1.3 -1.19 1.09 BM386651 protein tyrosine phosphatase, non-receptor type 14 Ptpn14_predicted -1.33 -1.4 -1.05 NM_053689 G protein-binding protein CRFG /similar to GTP-binding protein NGB Gtpbp4_predicted -1.36 -1.46 -1.08 U25281 SH3 domain binding protein CR16 /hypothetical gene NM_147211 /LOC364763Cr16 /LOC497785 -1.3 -1.52 -1.16 BE096731 NADPH oxidase organizer 1 /LOC498Noxo1_786predicted -1.26 -1.39 -1.11 BM386302 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) Vti1a -1.28 -1.21 1.06 BF397673 golgi phosphoprotein 4 Golph4_predicted -1.35 -1.36 -1.01 BF559398 sperm associated antigen 9 Spag9_predicted -1.43 -1.23 1.16 NM_022709 SMR2 RGD:619853 -1.21 -1.09 1.11 Protein turn over BF563800 similar to HECT domain containing 1* Hectd1_predicted -1.53 -1.15 1.33 BG671466 F-box only protein 23 /tetraspanin 17 /LOC362737Fbxo23;Tspan17_ pred. -1.23 -1.16 1.06 AW251625 tripartite motif protein 47 Trim47_predicted -1.34 -1.51 -1.13 BE117471 retinoblastoma binding protein 6 Rbbp6_predicted -1.26 -1.16 1.08 BF567998 sacsin ; spastic ataxia of Charlevoix-Saguenay Sacs_predicted -1.27 -1.4 -1.1 AW521399 inner membrane protein, mitochondrial Immt_predicted -1.32 -1.18 1.12 NM_012857 lysosomal membrane glycoprotein 1 Lamp1; Lgp120 -1.25 -1.21 1.03 NM_031595 proteasome (prosome, macropain) 26S subunit, ATPase 3 Psmc3 -1.17 -1.24 -1.06 translation / biosynthesis & metabolism / transport BF391342 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 U2af2_predicted -1.26 -1.4 -1.11 AI575608 similar to eukaryotic translation initiation factor 4E member 3 Eif4epb3; LOC297481 -1.24 -1.14 1.09 AA944176 leucyl-tRNA synthetase* Lars_predicted -1.23 -1.10 1.13 BF397926 guanine monphosphate synthetase Gmps_predicted -1.32 -1.28 1.03 U36771 glycerol-3-phosphate acyltransferase, mitochondrial Gpam -1.4 -1.46 -1.04 L46791 carboxylesterase 3 Ces3 -1.26 -1.2 1.05 BI289446 similar to hypothetical protein FLJ20302; similar to CG31653-PA RGD1307264_predicted -1.46 -1.43 1.03 BE119170 similar to CG5554-PA RGD1305146_predicted -1.36 -1.17 1.16 BG377269 aldehyde dehydrogenase family 1, subfamily A3 Aldh1a3 -1.21 -1.05 1.15 BI300599 vitelliform macular dystrophy 2-like protein 1 Vmd2l1_predicted -1.28 -1.17 1.09 NM_031332 solute carrier family 22 (organic anion transporter), member 8 Slc22a8 -1.58 -1.42 1.11 NM_053997 potassium voltage gated channel, Shaw-related subfamily, member 3 Kcnc3 -1.23 -1.4 -1.14 U81518 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) Slc14a1 -1.29 -1.37 -1.06

Downloaded from iovs.arvojournals.org on 09/24/2021 Supplementary Table 3B

IOP-GA IOP-GA IOP-PBS Public ID Gene Title Gene Symbol / IOP-PBS / N / N IOP Not Altered and GA Induced cell adhesion-matrix / signal transduction / development & motility BI275896 adipocyte-specific adhesion molecule Asam 1.29 1.3 1 BF398114 axin2 Axin2 1.29 1.45 1.13 NM_080778 nuclear receptor subfamily 2, group F, member 2 Nr2f2 1.37 1.71 1.25 X83537 matrix metalloproteinase 14 (membrane-inserted) Mmp14 1.23 1.26 1.02 AI406553 SWI/SNF related, matrix associated, actin dependent regulator of chromatin Smarcb1_predicted 1.19 1.03 -1.15 BF413643 von Willebrand factor A-domain containing 1 Vwa1_predicted 1.31 1.09 -1.19 AF000942 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein /RGD131Id3 1476 1.43 1.4 -1.02 NM_022628 nephrosis 1 homolog, nephrin (human) Nphs1_predicted 1.3 1.05 -1.23 BF561277 adrenergic receptor, alpha 2a Adra2a 1.35 1.15 -1.17 BG380629 RAS guanyl releasing protein 2 (calcium and DAG-regulated) Rasgrp2_predicted 1.32 1.27 -1.04 BM384841 RAB15, member RAS onocogene family Rab15 1.28 1.07 -1.2 BE117392 strain Wistar Rap2a mRNA, 5' UTR Rap2a 1.37 1.22 -1.12 BM390457 sprouty homolog 2 (Drosophila) Spry2_predicted 1.32 1.12 -1.18 AW521536 PSD-95 binding protein Dlgap1 1.37 1.13 -1.21 AA875041 leucine zipper, putative tumor suppressor 1 Lzts1 1.31 1.06 -1.24 AI703807 cysteine-rich motor neuron 1 Crim1_predicted 1.32 1.06 -1.24 BE106526 solute carrier family 6 (GABA neurotransmitter transporter), member 11 Slc6a11 1.27 1.52 1.2 BF386649 reticulon 4 receptor* Rtn4r 1.29 1.32 1.03 BM386987 similar to KIAA0933 protein RGD1306097_predicted 1.42 1.45 1.02 BF411765 cadherin EGF LAG seven-pass G-type receptor 2 Celsr2 1.24 1.37 1.11 BF400594 similar to odd Oz/ten-m homolog 2 (Drosophila) Odz2_predicted 1.33 1.41 1.06 BE106313 plexin A2 Plxna2_predicted 1.28 1.3 1.01 AI599568 radical fringe gene homolog (Drosophila) Rfng_predicted 1.25 1.05 -1.18 AA891664 manic fringe homolog (Drosophila) Mfng_predicted 1.2 1.4 1.17 BI282866 lamin A Lmna 1.2 1.22 1.02 Immune response / cell proliferation AA859752 noggin Nog 1.19 1.01 -1.18 BE107528 SMAD, mothers against DPP homolog 5 (Drosophila) Madh5_predicted 1.43 1.29 -1.1 NM_030858 MAD homolog 7 (Drosophila) Madh7_predicted 1.24 1.22 -1.01 NM_031019 corticotropin releasing hormone Crh 1.31 1.53 1.17 NM_134375 angiotensin/vasopressin receptor /NACHT Nalp6 1.35 1.15 -1.17 AI454052 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Kit 1.37 1.21 -1.14 AI511097 similar to PHD finger protein 6 Hprt 1.59 1.24 -1.28 cell cycle / transcription / cell signaling BI287978 growth arrest and DNA-damage-inducible 45 beta Gadd45b_predicted 1.25 1.11 -1.13 BE110915 cyclin-dependent kinase inhibitor 1B Cdkn1b 1.3 1.19 -1.09 BI278569 autophagy 7-like (S. cerevisiae) Atg7_predicted 1.27 1.05 -1.21 AI102530 Ngfi-A binding protein 2 Nab2_predicted 1.27 1.18 -1.08 NM_012551 early growth response 1# Egr1 1.98 1.98 -1 BF389776 a-thalassemia / mental retardation syndrome X-linked homolog (human) Atrx_predicted 1.28 1.26 -1.01 BM389055 euchromatic histone methyltransferase 1 Ehmt1_predicted 1.23 1.19 -1.03 BE117956 SET binding protein 1 Setbp1_predicted 1.51 1.88 1.25 BF285169 Ets2 repssor factor Erf_predicted 1.5 1.88 1.25 BG377337 Sal-like 1 (Drosophila) Sall1_predicted 1.26 1.39 1.1 NM_133602 KH-type splicing regulatory protein Khsrp 1.34 1.64 1.22 BM384145 SH3-domain binding protein 2 Sh3bp2_predicted 1.26 1.02 -1.23 AI232341 SH2 domain containing 4A Sh2d4a_predicted 1.21 1.19 -1.02 AA964494 pleckstrin homology domain-containing, family A, member 3 Plekha3_predicted 1.59 1.58 -1.01 AF077000 protein tyrosine phosphatase, non-receptor type 23 Ptpn23 1.35 1.47 1.09 NM_012637 protein tyrosine phosphatase, non-receptor type 1 Ptpn1 1.38 1.18 -1.16 AI043869 similar to Serine/threonine protein kinase 24 Stk24_predicted 1.23 1.18 -1.04 AB023896 endothelin converting enzyme-like 1 Ecel1 1.39 1.51 1.09 X65747 guanine nucleotide binding protein, a-transducing 3 Gnat3 1.19 1.08 -1.1 AY030276 G protein-coupled receptor 149 Gpr149 1.22 1.4 1.15 transport / metabolism / biosynthesis NM_031726 secretory carrier membrane protein 5 Scamp5 1.2 1.02 -1.18 AW920063 potassium voltage-gated channel, Isk-related family, member 2 Kcne2 1.37 1.3 -1.05 AI029975 strongly similar to NP_005493.2 ATP-binding cassette, sub-family A member Abca1_predicted 1.41 1.68 1.2 H35736 sol1 ute carrier family 25, member 30 Slc25a30 1.33 1.23 -1.08 BF403099 dynactin 6 Dctn6_predicted 1.25 1.18 -1.06 AW523874 similar to Hypothetical protein MGC59076 RGD1309144_predicted 1.33 1.4 1.05 NM_017074 CTL target antigen Cth 1.21 1.13 -1.07 NM_019243 prostaglandin F2 receptor negative regulator Ptgfrn 1.22 1.11 -1.1 AI169002 pyrroline-5-carboxylate reductase-like Pycrl_predicted 1.26 1.35 1.06 AA899304 acetyl-coenzyme A acetyltransferase 1 Acat1 1.24 1.11 -1.12 NM_032616 liver-specific bHLH-Zip transcription factor 7 Lisch7 1.24 1.24 -1 BM385726 dimethylarginine dimethylaminohydrolase 2 Ddah2 1.29 1.1 -1.17 AI228970 HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae) Hrmt1l6_predicted 1.24 1.22 -1.02 BI293388 hexokinase 3 Hk3 1.44 1.55 1.08 BI282331 similar to WD repeat domain 4 Wdr4_predicted 1.3 1.05 -1.24 AI008961 similar to PDZ domain containing 11 /LOC499412Pdzd11_predicted 1.22 1.24 1.02 BI293445 piggyBac transposable element derived 5 /LOC302422Pgbd5_predicted 1.19 1.13 -1.05 BM384752 similar to KDEL (Lys-Asp-Glu-Leu) containing 2 protein Kdelc2 1.38 1.26 -1.09

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