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Gummatous Lesions in Men Infected with Human Immunodeficiency Virus and Syphilis

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Gummatous Lesions in Men Infected with Human Immunodeficiency Virus and Syphilis Genitourin Med: first published as 10.1136/sti.66.5.374 on 1 October 1990. Downloaded from 374 Genitourin Med 1990;66:374-379 Gummatous lesions in men infected with Human Immunodeficiency Virus and Syphilis P E Hay, F W K Tam, V S Kitchen, S Horner, J Bridger, J Weber Abstract accelerated progression to manifestations of tertiary Two HIV-infected men are reported who neurosyphilis.'3 In the last 2 years two cases of developed gummatous lesions more than 12 benign tertiary syphilis in HIV-positive men have months after appropriate treatment of been reported from London, and one in an HIV presumptive syphilis. In one patient the lesions antibody negative homosexual man.78 We report a developed without any change in the VDRL further two cases in HIV-positive men. titre. The most likely explanation for these lesions is reactivation of syphilis in the context Case 1 of HIV infection. As these lesions respond to A 44 year old bisexual man presented in 1985 with a penicillin, the possible reactivation of painless ulcerated lesion on the penis (fig la). He had appropriately treated syphilis, or even yaws, a long history of treatment for syphilis, which is should now be considered in any ulcerative summarised in fig 2. He was born in Jamaica, and lesion in HIV infected individuals at risk from received a course of bismuth in Antwerp one year treponemal infection. prior to his first course of procaine penicillin in the UK in 1967. He had many sexual partners over the next 15 years, and was treated for gonorrhoea on four Introduction occasions. He had multiple courses of treatment for The ulcerative or nodular manifestation of benign syphilis. On three occasions small dark-ground tertiary syphilis known as a gumma occurred in 16% negative genital lesions developed in association with of 1147 patients with untreated syphilis in the Oslo a rise in VDRL titre. Study.' It is now rarely seen although a decline in In the mid 1970s bilateral sensorineural hearing incidence was noted prior to the introduction of loss developed in association with interstitial http://sti.bmj.com/ penicillin.2 A gumma is thought to represent an keratitis. Despite prolonged courses of steroids and enhanced immune response to Treponema pallidum penicillin almost total deafness ensued over the next 5 as organisms are present in low numbers in the years. The occurrence of these two features of lesions. Healing occurs promptly after antimicrobial Hutchinson's triad suggested the diagnosis of con- treatment leaving a "tissue paper" scar. genital infection, although they can occur in acquired Many HIV-positive patients have a history of infection. Mild aortic regurgitation was diagnosed in syphilis, and it has been suggested that the natural 1976. Whilst this may have been unrelated to on October 1, 2021 by guest. Protected copyright. history of syphilis is altered in such patients with an syphilis, cardiovascular involvement is more likely to increased probability of treatment failure, and an occur in late acquired than in congenital syphilis. It is possible that he had manifestations of both. The last treatment for syphilis was in 1984, following contact with an infectious individual, when he received Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ epidemiological treatment with doxycycline 300 mg P E Hay per day for 10 days. The VDRL titre remained at Infectious Diseases Unit, Hammersmith Hospital, 1/64 before and after this treatment. During the Du Cane Road, London W12 OHS intervening year he had reduced his number of F W K Tam, J Weber partners to two, after being advised that he was a Department of Genito-Urinary Medicine, St Mary1. hepatitis B carrier. Hospital, Norfolk Place, London W2 lNY The ulcer had been steadily increasing in size until P E Hay, V S Kitchen it measured 6 cm by 3 cm. Generalised lympha- Department of Pathology, St Mary's Hospital, denopathy was noted. Serum antibodies to HIV 1 Norfolk Place, London W2 lNY S Homer were present, and the VDRL titre was now 1/512. Repeated dark-ground examinations were negative. Department of Pathology, Hammersmith Hospital, Du Cane Road, London W12 OHS, UK A biopsy was performed to exclude malignancy. The J Bridger histological features were consistent with benign tertiary syphilis, showing granulomatous inflamma- Genitourin Med: first published as 10.1136/sti.66.5.374 on 1 October 1990. Downloaded from (a) A.. http://sti.bmj.com/ on October 1, 2021 by guest. Protected copyright. (b) Figure 1 (a) A large painless penile ulcer in case 1, prior to treatment. (b) Healed ulcer in case 1, six weeks after treatment with penicillin. There is scarring on the underside of the penis, corresponding to the site of the gumma. Genitourin Med: first published as 10.1136/sti.66.5.374 on 1 October 1990. Downloaded from 376 Hay, Tam, Kitchen, Horner, Bridger, Weber tion with sparse giant cells. There was marked Tetracycline had been administered for non-gono- vascular involvement with adventitial cuffs ofplasma coccal urethritis on nine occasions. Serological tests cells admixed with chronic inflammatory cells (fig 3). for syphilis showed a positive RPR on undiluted Mycobacteria, fungi and treponemes were not detec- serum, TPHA and FTA both strongly positive. ted by appropriate stains or electron microscopy. It Treatment with acyclovir and ketoconazole was was concluded that the lesion was a gumma, and commenced, and zidovudine 200 mg 4 hourly was absence ofnecrosis was due to the biopsy being taken added in 1988. At that time he complained of severe from the edge of the lesion. generalised pruritis. The possibility of lymphoma Benzathine penicillin (2-4 MU) was administered was considered, but chest radiograph, CT of chest and repeated after 6 days. The ulcer healed within 6 and abdomen were normal. Excision biopsy ofa right weeks, with some residual scarring (fig lb). The inguinal lymph node showed follicular hyperplasia VDRL titre fell to 1/32. Further courses of doxy- with plasma cell proliferation in the interfollicular cycline have not produced any change in the VDRL areas, but no evidence of lymphoma. titre. The lymphadenopathy remains the only sign of In 1989 two nodular lesions, 0.5 cm in diameter, HIV infection. developed in his right groin. There was induration with superficial ulceration (fig 4). Syphilis serology Case 2 was unchanged from 1987. Histological examination A 51 year old bisexual man, originating from of an excision biopsy showed the features of a Dominica, was diagnosed HIV antibody positive in gumma. Treponemes were not seen on silver stains, 1987 when he presented with peri-anal ulceration and no fungi or mycobacteria were visualised, or due to Herpes simplex, generalised non-tender grown on culture. lymphadenopathy, and oral candidosis. He had tissue There was no evidence of neurological or cardio- paper scars on his legs compatible with his history of vascular syphilis. Chest radiograph, cardiac previously treated yaws. ultrasound, bone scan and cerebrospinal fluid His sexual history included frequent visits to examination were normal. A course of three doses of prostitutes. Over the previous 25 years he had 2.4 MU benzathine penicillin was administered over received treatment with penicillin for presumptive 3 weeks. The site of the biopsy healed uneventfully, syphilis at least 6 times, and gonorrhoea 10 times. with resolution of the underlying induration. pred B PP P P P PP A A - A P PP P P P P D P I I I r II I I IIy http://sti.bmj.com/ | Aortic Regurgitation |-HIV +ve 13-1nterstitial Keratitis j|-HbsAg+ 1024 | Deafness VDRL 512 TITRE 256 on October 1, 2021 by guest. Protected copyright. 128 64 32 16 8 4 D:Doxycyline B: Bismuth P: Penicillin 2 A: Ampicillin Pred: Prednisolone nt 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 year Figure 2 Outline of 19years ofsyphilis and treatment in case 1 showing the relationship between serum VDRL, time, development of complications and courses of treatmentfor syphilis. Genitourin Med: first published as 10.1136/sti.66.5.374 on 1 October 1990. Downloaded from AW 4a Figure 3 Histological sectionfrom penile biopsy in case 1 showing periarteritis in a sub-dermal arteriole, with adventitial cuffs ofplasma cells and lymphocytes, admixed with chronic inflammatory cells (Haematoxylin and eosin x 190). Discussion Histologically a gumma is a granuloma with epithelioid and giant cells present, obliterative endarteritis and areas of necrosis. It is thought to http://sti.bmj.com/ represent a hypersensitivity response to a small number of treponemes. Olansky extensively reviewed the aetiology of gummas and concluded that they can arise either from reactivation of syphilis present in an untreated or inadequately treated individual, or from reinfection in a previously sensitised individual.9 Certainly gummas can follow on October 1, 2021 by guest. Protected copyright. reinoculation in sensitised individuals. In the Sing- Sing Prison study, in which Nichols strain T. pallidum was inoculated into human volunteers, one of the five subjects with a history of treated congenital syphilis developed a gumma at the site of inoculation, as did one ofthe patients with previously treated late syphilis.'0 The term pseudo-chancre redux has been applied to gummatous lesions occur- ring at the site of an earlier chancre." It is distin- guished from a chancre redux by the absence of demonstrable treponemes on a dark ground examina- tion and of local lymphadenopathy. Although the patient described in case 1 never had a chancre demonstrated in our clinic it is possible that this was a pseudo-chancre redux. There is evidence that T. pallidum persists in some patients who have received what is regarded as adequate therapy for syphilis.'2"6 It has been sugges- ted that T.
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