NHIRC DAY Tuesday, February 5, 2013 St. Paul’s Church, Concord NH

Governor Maggie Hassan and ATTENDEES from NH LEGISLATURE

Sen. Sam Cataldo Rep. Sue Gottling Rep. David Murotake Sen. Jeanie Forrester Rep. Jim Grenier Rep. Wendy Piper Sen. Andrew Hosmer Rep. Ken Grossman Rep. Larry Rappaport Sen. Bette Lasky Rep. Marcia Hammon Rep. Ian Raymond Sen. Russell Prescott Rep. Daniel Hansberry Rep. Rosemary Rodgers Sen. John Reagan Rep. Laurie Harding Rep. Chip Rice Sen. David Watters Rep. Linda Harriott-Gathright Rep. Leon Rideout Sen. Jeff Woodburn Rep. Jeffrey Harris Rep. Laurie Sanborn Rep. Caroletta Alicea Rep. Patricia Higgins Rep. Emily Sandblade Rep. Bill Baber Rep. Rep. Frank Sapareto Rep. Bob Backus Rep. Gladys Johnsen Rep. Rep. Christy Bartlett Rep. Naida Kaen Rep. Jan Schmidt Rep. Bernie Benn Rep. Sally Kelly Rep. Marge Shepardson Rep. Rep. Mary Ann Knowles Rep. Suzanne Smith Rep. Rebecca Brown Rep. Peter Leishman Rep. Rep. Tom Buco Rep. Rick LeVasseur Rep. Kevin St. James Rep. Betsy Burtis Rep. Robert Luther Rep. Cynthia Sweeney Rep. Ed Butler Rep. Dennisq Malloy Rep. Robert Theberge Rep. Frank Byron Rep. John Mann Rep. Mary Till Rep. Jackie Cali-Pitts Rep. Maureen Mann Rep. Jim Verschueren Rep. Glenn Cordelli Rep. Dick Marston Rep. Rep. Jim Devine Rep. Linda Massimilla Rep. Mary Beth Walz Rep. Linda DiSilvestro Rep. H. Robert Menear Rep. Rick Watrous Rep. Tracy Emerick Rep. Marcia Moody Rep. Brian Wazlaw Rep. Eileen Flockhart Rep. Rep. Chuck Weed Rep. Carolyn Gargasz Rep. Catherine Mulholland Rep. Lisa Whittemore Rep. Ken Gidge Rep. John Mullen Rep. Robert Willette Rep.

NHIRC DAY Tuesday, February 5, 2013 St. Paul’s Church, Concord NH

ATTENDEES from INNOVATIVE COMPANIES that have received NHIRC awards

Don Banfield, CEO Conductive Compounds Ryan Banfield Conductive Compounds David DeLucia, CEO ImmuRX, Inc. Jon Goering, Divisional CTO Albany Engineered Composites Bill Hersman, Founder & CEO Xemed Russell Mason, VP Sales & Marketing, CIO ArgenTech Solutions Ray Pasquale, Founder & CEO Unified Office Jake Reder, CEO Celdara Medical, LLC John Shaw, President Itaconix, LLC Jim Steed, VP of Sales Optical Systems Doug Vincent, President & CEO Design Mentor, Inc.

NHIRC Board Members and Guests

Martha Fuller Clark NH Senate Representative Alla Kan Technology Transfer, Dartmouth Jan Nisbet Senior VP for Research, UNH John Orcutt Professor, UNH Law School Beatriz Pastor NH House Representative Marc Sedam NHIRC Executive Director Glenn Shwaery Assoc. Dean, Research, UNH Gretchen Smith NHIRC Program Manager Chris Way Business Service Manager, NH DRED

Jim Dreher, Owner Durham Boat Company Mica Stark Government Relations, UNH

Albany Engineering Composites (AEC) is a division of Albany International Corp. (AIC), and is headquartered in Rochester, NH. AEC designs, develops, and manufactures advanced composite components for the aerospace and other high-performance markets, using innovative proprietary technologies. AEC was formed in 2005 by combining AIC’s existing Engineered Products Group with Techniweave (a small New Hampshire business acquired in 1998) and Texas Composites (a small Texas business acquired in 2005).

Product lines, facilities, annual sales: AEC has facilities in Rochester, NH, and in Boerne, TX. In Rochester, there are currently two operations that house manufacturing of 3D woven structures and research and technology, including a new 45,000-square-foot Research & Technology Center. AEC will be co-located with Safran Aerospace Composites in a 353,000-square-foot plant currently under construction in Rochester, where it will produce composite parts for the CFM LEAP engine. A second LEAP plant is currently under construction in Commercy, France. AEC’s facility in Boerne, Texas, specializes in molding composite components for aerospace applications. Sales through the third quarter of 2012 were $47.7 million.

Number of New Hampshire employees: 353 as of December 2012

CEO, officers: Joseph G. Morone, President & CEO of Albany International Corp. Ralph Polumbo, Chief Operating Officer Diane Loudon, Senior Vice President, Operations Brian Coffenberry, Senior Vice President, Business Development, Research & Technology Jon Goering, Divisional Chief Technology Officer and Technical Leader for NHIRC Project

NHIRC Awards

Elimination of Microrcracking in 3D Woven Igor Tsukrov, Mechanical 12/3/10 – 6/30/12 UNH Composite Structures Engineering Elimination of Microcracks in 3D Woven Igor Tsukrov, Mechanical 5/15/09 – 5/31/10 UNH Composites Engineering Characterization and Evaluation of AIT's Gas V.K. Mathur, Chemical 12/12/01- 6/30/04 UNH Diffusion Layer for Fuel Cells Engineering Development and Characterization of High V.K. Mathur, Chemical 6/18/99- 7/31/02 UNH Temperature Ceramic Braided Seals Engineering

Impact The technology developed in this project has allowed us to broaden our markets by expanding the range of components that can be fabricated using 3D weaving and resin transfer molding. These technologies are relatively new, but are being used in some major programs, such as the CFM LEAP engine program and the landing gear braces for the Boeing 787. Our LEAP program alone will bring approximately 300 manufacturing and engineering jobs into the area by the end of the decade. This commitment to New to leverage our experience with composite engine component programs to expand into composite airframe applications. This additional growth is expected to bring in another 200 jobs. Again, these will be primarily manufacturing and engineering jobs that will require skills ranging from specialized machine operation, to shift supervision, to production planning, to product engineering.

This project requires very specific skills in solid mechanics, experimental methods, and computer programming and we are fortunate to have access to all of these at the University of New Hampshire. Without this help, we would likely pursue a teaming arrangement with another university with which we have past experience, such as the Georgia Institute of Technology, Rensselaer Polytechnic Institute, or Kansas State University.

Leveraged Funding This project let to a successful proposal to a National Science Foundation (NSF) project award to answer fundamental research questions regarding the driving force for damage initiation. The NSF program will also provide validation of the modeling approach that was developed in the NHIRC program and is expected to bring the model to a mature enough stage to be used as a design tool.

Started in March of 2009, ArgenTech Solutions (AgTS) specializes in emerging and innovative technologies that can be rapidly integrated to enhance system performance. AgTS provides mission critical frontline field services to the US Department of Defense (DoD) in support of unmanned aircraft systems (UAS); and product and solution development for both DoD and commercial use. This product development includes innovative coatings and anti-traction materials.

Number of New Hampshire employees: Nine (9); fifty four (54) employees total.

CEO, Officers: Keith Haney, President Glenn Shwaery, Chief Scientist Russell Mason, VP, Marketing & Sales; CIO and contact person Robert Meyer, VP; COO Ken Bisconer, VP, UAS Services

NHIRC Projects

Development of High Performance John Tsavalas 9/1/12-5/31/13 UNH Photoluminescent Based Powder Coatings Chemistry Encapsulation of Anti-traction Material for Nivedita Gupta 1/1/13- UNH Security Applications Chemical Engineering

Impact Projected sales consider two markets – military and commercial. Once perfected and certified for use (e.g. MIL STD, UL or New York MEA) products are sold directly or through strategic coating partners with greater channel access. The manufacture of a photoluminescent (PL) pigmented additive to powder coating material in New Hampshire is entirely feasible and would create employment for up to 36 individuals in manufacturing, engineering and service support. Having students involved as part of the design is our approach to helping grow organic talent needed to create manufacturing jobs in NH. If AgTS does not pursue a direct manufacturing capability, several New Hampshire based powder coating enterprises could still benefit from the availability of a unique NH based PL powder coating technological development that would improve their sales and services.

Leveraged Funding To improve the performance of photochromic pigments a second Phase II award DoD-funded effort will provide an additional $250,000 toward development and commercialization of related technologies and application techniques. Receipt of this NHIRC award will enable us to initiate the effort to microencapsulate the pigmented phosphors for powder coating applications.

Celdara Medical, LLC 16 Cavendish Ct. Lebanon, NH 03766 USA

Celdara Medical, LLC (CM) is an early stage medical development company that is bringing the highest- potential inventions out of academic labs and into the marketplace. CM was founded in 2008 and is located in Lebanon, NH. We are advancing five funded Programs (with many more in the pipeline): a scleroderma diagnostic service that is in the market, an immunologic therapeutic for MI that is preclinical, an anti-inflammatory that is at in vivo proof-of-concept, an anti-atherosclerotic that is preclinical, and a cellular therapy which is expected to go into the clinic at the end of this year. One example, initially funded by NHIRC: a proprietary genetics-based diagnostic test that can predict clinical outcomes for victims of scleroderma and other skin diseases. Scleroderma is a poorly understood skin disease that affects 300,000 Americans, and is characterized by painful thickening of the skin, organ damage, and often, death. Our diagnostic test enables doctors to choose treatment options and therapeutics based upon accurate prognoses and expected response to therapy. CM is the only company able to subtype scleroderma. Number of New Hampshire employees: CM currently employs nine people full time, and has ~30 engaged (consultants, contractors, part-time, interns, etc). Additionally, we have established an affiliate in Seattle, WA (Virtici Corp.) and are working with universities from across the country. We have been approached by ~40 universities requesting that we setup affiliates at their institutions, and are considering various expansion scenarios.

CEO, Officers: Jake Reder, Ph.D., CEO and Director of New Ventures at the Geisel School of Medicine at Dartmouth Michael Fanger, Ph.D., Chairman and CSO, Professor and former Chair of Microbiology and Immunology at the Geisel School of Medicine at Dartmouth.

NHIRC Projects Cellular Immunotherapy 5/14/10- Dartmouth Charles Sentman, Microbiology for Cancer 11/30/11 Medical School and Immunology 12/5/08- Dartmouth Scleroderma Diagnostics Michael Whitfield, Genetics 2/28/11 Medical School

Impact Thanks to the early support of the NHIRC, CM has brought our scleroderma diagnostics service to the market and is currently supporting drug developers in their clinical trials as well as individual clinicians through our CLIA certified lab. We continue to advance the science behind this Program with e.g. SBIR funding (we currently have a Phase I award worth >$500k), and were profitable in our first year of sales. NHIRC funding also helped us to advance our cellular therapy for cancer, which has attained over $4M in NIH SBIR funding, some of which will support a Phase I clinical trial (patients will be enrolled at the Dartmouth-Hitchcock Medical Center). We have also recently signed a term sheet (A round: $10M) after being approached by a major Boston-area VC to spin out this technology. In total, we have attained almost $10M in funding (not including the $10M investment mentioned above) in our four-year history, the majority of that coming in 2012. In dollars, the NHIRC funding was small, but in impact, it was huge – it was early, and allowed us to position ourselves to be successful with both NIH grants and venture investors. This is the only program in NH that addresses this critical need. When most other states are actively expanding their early stage tech company support, NH should be doubling down, not considering retreat!

Conductive Compounds, Inc. is a Hudson, NH based manufacturer of specialty ink, coating, sealing and adhesive materials used by manufacturers of printed electronics and electronics assemblies. Founded in 1994, Conductive Compounds, Inc. leased its first research and production facility in Londonderry, NH in 1999 and moved to the current facility in 2008. In the new and rapidly growing area of nanoparticles, there is a lot of hype surrounding the claimed properties and commercial feasibility of nanoparticle with limited demonstrations of fusible nanoparticle conductive inks. These inks are not currently commercially viable due to limitations of other properties such as adhesion to substrates, higher fusing temperatures and most importantly cost. Most efforts on nanoparticle conductive ink development have focused on digital (inkjet) printing to deliver the conductive ink to a suitable substrate and then allowing it to fuse as the ink dries. While there have been demonstrations of commercial printing these inks onto paper and other substrates, to date there have been very limited fully commercial applications of digital printed nanoparticle conductive inks.

Number of New Hampshire employees: Fourteen (14) in NH facility and has 13 direct and indirect sales reps located throughout Asia and Europe.

CEO, officers: Don Banfield , CEO; E. Sue Banfield, Secretary; J. Eileen Banfield, Treasurer

NHIRC Project

Silver Nanoparticle Synthesis and Process Design for Dale Barkey 1/1/11- 12/31/12 UNH Printable Conductive Media Chemical Engineering

Impact Successful commercialization will require additional personnel in research and manufacturing at Conductive Compounds, Inc. Our preliminary estimates are that a minimum of seven to ten additional personnel would be required initially to support production scale up, sales and further technical development. This project has engaged four undergraduate chemical or environmental industrial process engineering majors. The resulting development of knowledge capital, and the direct interaction of undergraduates with us has increased the potential for hiring and retention of UNH students in productive careers in the state.

Leveraged Funding The NHIRC project allowed us to apply for and receive federal funding from the National Science Foundation for $450,000 to carry the project forward. Without the initial NHIRC funding we would have had a more difficult, if not impossible, task of obtaining this additional funding.

Design Mentor, Inc. is a Pelham-based developer of medical devices for Fortune 100 Med-Tech companies and Med-Tech startups, who has partnered with Dartmouth College to conduct testing on their patented pulsatile-pressure cardiopulmonary bypass (CPB) pump, VentriFlo. The VentiFlo mimics the physiological flow of blood from the human heart during open heart surgery, and compared to existing continuous flow pumping approaches, promises to offer improved patient outcomes, fewer post-surgical complications (such as kidney failure), and lower overall healthcare costs. The partnership is possible thanks to support from the N.H. Innovation Research Center (NHIRC) at the University of New Hampshire.

Product lines, facilities, annual sales: Design Mentor is a design and development company specializing in next generation product development for the Medical Device Community. Since 2002, we have also been developing VentriFlo for the cardiothoracic surgical suite in order to improve patient outcomes, reduce post-surgical complications, and thereby reduce overall healthcare costs. We have 7500 sq ft of office and laboratory space, and have had up to 35 employees on site. The revenues from our engineering services have averaged ~$1.5MM/yr for the last 12 years, and up until the partnership with the NHIRC and Dartmouth, have been the source of investment funding (~$2MM to date) for the VentriFlo program.

Number of New Hampshire employees: currently < 5 (though varies significantly with project scale and longevity, etc.)

CEO: Doug Vincent, President & CEO

NHIRC Project

Ryan Halter Pulsatile Pressure Pumping for 1/1/11-12/31/12 Dartmouth Thayer School of Cardiopulmonary Bypass Engineering

Impact: Matching Funds from the NHIRC have been CRUCIAL for preparing the test data and clinical partnership required to compete for federal funding. Our research partner, Dr. Ryan Halter has moved his research in a new direction due to this project and has been actively applying for research funding from both the NIH and Dartmouth. He has also integrated these research activities directly into a Surgery for Engineering course, engaging Dartmouth students in state-of-the-art cardiopulmonary bypass technologies.

Leveraged Funding: We plan to apply to the National Institutes of Health (NIH) for a Small Business Innovation Research Grant (SBIR) which will support much of the investment required for regulatory approval and subsequent commercialization.

ImmuRx was founded in 2005 to develop a drug platform discovered by Dartmouth Professor Randolph Noelle which stimulates the immune system so well that it may be able to treat a wide variety of cancers such as melanoma, lymphoma and lung cancer. It may also treat chronic infectious diseases such as hepatitis C and tuberculosis.

The successor company, ImmuNext is developing novel therapeutics that modulate the immune system to treat cancer and autoimmune diseases. ImmuNext recently signed a deal with Johnson and Johnson worth over $150,000,000 in upfront fees, sponsored research and potential milestone payments.

Number of New Hampshire employees: ten (10)

CEO: David DeLucia

NHIRC Projects

Optimization of Immune System Stimulant in Mary Jo Turk 12/4/09- 12/31/10 Dartmouth Preparation for Human Clinical Evaluation Microbiology and Immunology

Drug Platform for Cancer and Infectious Randolph Noelle 11/30/07-12/31/09 Dartmouth Disease: Development of Component for Microbiology and Immunology Human Use

Impact NHIRC awards were the first funding we had. They catalyzed the growth of ImmuRx and the successor company, ImmuNext. We have discovered new drugs that may advance the treatment of cancer and autoimmune diseases, and have created 10 high tech jobs and expanded the NH Biotech sector.

Leveraged Funding • Raised >$10,000,000 in NIH SBIR grants and private equity • Strategic partnership with Johnson and Johnson worth >$150,000,000 in potential milestones • Sponsored >$2,000,000 in research at Dartmouth

Itaconix Corporation is the world leader in polymers from itaconic acid. We produce polymers for everyday applications that achieve two essential objectives - performance and sustainability. Itaconic acid is a bio-based renewable material produced from carbohydrates by fermentation. Using green chemistry and engineering, this new technology offers a chance to replace petrochemicals with 100% bio-based, sustainable polymers. Itaconix currently produces two different grades of polyitaconic acid that are used to improve the performance and reduce the cost of consumer laundry detergents and boosters, automatic dishwasher detergents and hard surface cleaners.

Number of New Hampshire employees: twelve (12)

CEO, Officers: John R. Shaw, CEO, Director & co-founder Yvon Durant, CTO, Director & co-founder David Shaw, Director

NHIRC Projects

Purification Technology for the Production of Itaconic Acid 1/1/11- 12/31/11 UNH Jennifer Durant Biochemistry

Polyitaconic Esters 12/4/09- 12/31/10 UNH Yvon Durant Material Sciences

Continuous Polymerization of Itaconic Acid 5/15/09- 11/30/10 UNH Yvon Durant Material Sciences

Process Scale up for the Polymerization of Itaconic Acid 12/5/08- 12/31/09 UNH Yvon Durant Material Sciences

Impact • Itaconix launched its first polymer in 2009 based on the Process Scale Up NHIRC project. This polymer is being used in a growing number of leading consumer detergent and cleaner products. • The company built its production pilot and its expanded production facility based on the Continuous Polymerization NHIRC project. The facility employs 12 people. • The company is developing new polymers based on the Polyitaconic Esters NHIRC project. UNH recently received a new patent based on this project. • The company is planning to integrate into the fermentation of itaconic acid based on the Purification NHIRC project. UNH and Itaconix filed a patent based on the work completed in this project.

Leveraged Funding DOE-USDA $1.8million research grant.

New Hampshire Optical Systems (NHOS) was formed in 2010 to serve the people of New Hampshire as a Competitive Local Exchange Carrier (CLEC). Our corporate headquarters is located in Nashua, NH with several other satellite offices around the state. NHOS was chosen by University of New Hampshire (UNH) to be a Broadband Technology Opportunities Program (BTOP) sub recipient from five finalists following an intensive 5 month open bid and evaluation process. NHOS’s middle mile project falls under Network New Hampshire Now (NNHN) BTOP grant award from the National Telecommunications and Information Administration (NTIA).

NHOS has constructed over 450 mile of the 750 miles and is on schedule to complete this June. This will provide all new next-generation fiber optic cabling across all 10 counties in New Hampshire. We have engineered this fiber optic network to provide a next generation IP platform to all businesses in NH. Our product offering will allow customers access to new services and provide them with choices historically not offered in NH. This network will allow NH businesses the ability to access services typically only available in larger cities, and provide economic growth by lowering the cost of connectivity in towns like Keene, Berlin, and Littleton.

Number of New Hampshire employees: five (5), estimate hiring 5 more for EOY 2013

CEO, Officers: Rob Carmichael, President and Chairman Jackie Hayes, Chief Financial Officer Steve Janko, Chief Technology Officer Jim Steed, Vice President

NHIRC Project

Turning on the Light on the Scott Valcourt, 5/1/12 – 6/30/13 UNH Dark Fiber Model Strategic Technology IT

Impact The implementation of SDN/Open Flow will allow for innovative routing and switching protocols in our network. It is used for applications such as virtual machine mobility, high-security networks and next generation IP based mobile networks.

Leveraged Funding The research work associated with SDN/OpenFlow will likely result in the ability to be strongly competitive for US IGNITE funding from the White House developing program, as well as NSF GOALI and SBIR/STTR funding. However, private investment will likely be the best source for future funding to expand this work. Additionally, NHOS would be the first SDN/OpenFlow provider in NH and would have competitive advantage over other providers in the state.

Unified Office was incorporated in February 2011 to develop and market an affordable integrated IP (Internet Protocol) premise and cloud-based business communications service for the Small and Medium-Sized Business (SMB) marketplace, primarily those with 10 to 100 employees.

Today the business world operates in real-time (Twitter, LinkedIn, Facebook). New legislation from Washington, such as “Obamacare”, provides new challenges in terms of regulatory compliance. That coupled with rapid pace of technology innovation over the last few years, in particular cloud-based systems, smarter smartphones, a whole new category of device in the form of tablets, and BYOD practices provide significant challenges for businesses of all sizes but in particular the SMB.

Current solutions are generally too expensive to deploy and typically don’t provide capabilities that meet the emerging needs of the SMB.

In contrast, Unified Office was built from the ground up to focus on emerging alternative devices (tablets, smartphones) to deliver a managed business-class communications service that absorbs the complexity of cloud-based systems, smartphones, tablets and BYOD, and creates easy-to-use innovative services based on open systems, to allow customers to be more productive and competitive.

Number of New Hampshire employees: five (5)

Officers: Ray Pasquale, CEO & Founder Roger Tuttle, CFO Mark Galvin, Chairman

NHIRC Award

Erica Johnson and Niels Widger Unified Office IP-PBX 1/1/2011- 9/30/2011 UNH lnteroperability Lab

Impact NHIRC funding enabled Unified Office to initiate interoperability testing in a timely manner and allowed the company to accelerate its market launch schedule. The students involved gained valuable experience with VoIP technologies that can be applied to other VoIP testing efforts at the UNH-IOL and future careers in the telecom/data communications industries.

http:www.xemed.com

Xemed LLC is a New Hampshire based medical technology company formed in July 2004 by Professor Bill Hersman as a spin-off from UNH’s Physics Department. Xemed licensed UNH’s patented laser-based technology to magnetize (“hyperpolarize”) helium and xenon gases, which can be safely inhaled into the lungs and interrogated with magnetic resonance imaging. Because no ionizing radiation is used in the product or imaging process, it is deemed safe for children and adults. Xemed’s services include testing new therapies from pharmaceutical companies, developing new support technologies for bringing hyperpolarized gases to the clinic, and demonstrating the utility of integrating hyperpolarized gas diagnostic capability into the healthcare infrastructure.

At Xemed, our mission is to develop inhaled diagnostic agents that are capable of improving the standard of care of respiratory diseases. We will accomplish this by establishing hyperpolarized gas as a scientifically robust, clinically validated, FDA approved, and publically available diagnostic agent for magnetic resonance imaging of lung functional microstructure. We work to demonstrate effectiveness in two fields: 1) guiding clinical management of respiratory diseases, and 2) as a drug development tool to evaluate of the safety and efficacy of new therapies.

Number of New Hampshire employees: 12

CEO, Officers: Bill Hersman is sole member of the LLC and serves as its part-time chief executive officer while also maintaining full-time duties as a Professor of Physics at UNH

NHIRC Project MRI Scanner for Hyperpolarized Xenon MRI of Human Lungs: A New Hampshire 12/8/06 – 6/30/10 UNH Bill Hersman, Physics Infrastructure and Research Initiative

Impact The NHIRC grant supported an industry-academic collaboration to demonstrate the potential of our hyperpolarized gas products to achieve high-resolution images of lungs and quantify the uptake of gases into the lung’s tissues and fluids. A key component on the academic side was the direction of an excellent Fulbright scholar PhD candidate who was successfully embedded into an extensive collaboration with state-of-the-art MRI scanners, first involving Harvard and later including the University of Virginia. By drawing on the best expertise nationwide, she was able to adapt cutting- edge technologies and methods for use with hyperpolarized xenon. Concurrently Xemed developed a portable version of its xenon polarizer and mechanical infrastructure for a novel transmit and receiver system for the human chest. The project earned UNH’s Isabel Dregely the Young Investigator Award from the International Society of Magnetic Resonance in Medicine, and the heightened awareness of Xemed’s capabilities resulted in commissioning the manufacture of two new xenon polarizers and hiring of two additional employees.

Leveraged Funding At the time the NHIRC project was awarded, Xemed was surviving on very limited funding, including a remortgage of the founder’s home. Since the technology was demonstrated through the NHIRC grant, Xemed has raised $7M in non- dilutive capital through competitive research grant proposals, diversified its revenue stream, and attracted over $2M in commercial goods and professional service contracts.