FXYD5 Antibody Cat. No.: 28-255

FXYD5 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human FXYD5.

TESTED APPLICATIONS: ELISA, WB

FXYD5 antibody can be used for detection of FXYD5 by ELISA at 1:1562500. FXYD5 APPLICATIONS: antibody can be used for detection of FXYD5 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. 1205 - Jurkat Cell Lysate

PREDICTED MOLECULAR 20 kDa, 19 kDa WEIGHT:

Properties

PURIFICATION: Antibody is purified by A chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

October 2, 2021 1 https://www.prosci-inc.com/fxyd5-antibody-28-255.html Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: FXYD5 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: FXYD5

ALTERNATE NAMES: FXYD5, HSPC113, IWU-1, IWU1, KCT1, OIT2, PRO6241, RIC, dysad, DYSAD

ACCESSION NO.: NP_054883

PROTEIN GI NO.: 21618361

GENE ID: 53827

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

FXYD5 is a member of a family of small membrane that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein.This reference sequence was derived from AF161462.1 and ESTs; validated by multiple replicate ESTs and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35- BACKGROUND: amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Two transcript variants have been found for this gene, and they are both predicted to encode the same protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected].].

REFERENCES: 1) Batistatou, A., (2005) Br. J. Cancer 93 (12), 1382-1387.

October 2, 2021 2 https://www.prosci-inc.com/fxyd5-antibody-28-255.html ANTIBODIES FOR RESEARCH USE ONLY.

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