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44Th Annual Drosophila Research Conference
54th Annual Drosophila Research Conference 2013 Drosophila Genetics Washington, DC, USA 3-7 April 2013 ISBN: 978-1-62748-965-2 Printed from e-media with permission by: Curran Associates, Inc. 57 Morehouse Lane Red Hook, NY 12571 Some format issues inherent in the e-media version may also appear in this print version. Copyright© (2013) by the Genetics Society of America (GSA) All rights reserved. Printed by Curran Associates, Inc. (2013) For permission requests, please contact the Genetics Society of America (GSA) at the address below. Genetics Society of America (GSA) 9650 Rockville Pike Bethesda MD 20814-3998 Phone: (301) 634-7300 Fax: (301) 634-7079 [email protected] Additional copies of this publication are available from: Curran Associates, Inc. 57 Morehouse Lane Red Hook, NY 12571 USA Phone: 845-758-0400 Fax: 845-758-2634 Email: [email protected] Web: www.proceedings.com OPENING/GENERAL SESSIONS Wednesday, April 3 7:00 PM–9:00 PM Thursday, April 4 8:30 AM–12:35 PM Opening General Session Plenary Session I Co-Moderators: Richard Mann, Columbia University, New Moderator: David Stern, Janelia Farm Research York and Kristin Scott, University of California, Berkeley Campus, Ashburn, Virginia Room: Marriott Ballroom Salons 1-3, Lobby Level Room: Marriott Ballroom Salons 1-3, Lobby Level Presentations: 8:30 am Image Award Presentation. David Bilder. Presentations: University of California, Berkeley. 7:00 pm Welcome and Opening Remarks. Richard Mann. Columbia University, New York. 7:15 pm GSA Welcome and Update. Adam Fagen. Genetics Society of America, Bethesda, Maryland. 8:35 am Molecular Mechanisms of Axon 1 7:25 pm Larry Sandler Award Presentation. -
Kv1.1 Channels Regulate Early Postnatal Neurogenesis in Mouse Hippocampus Via the Trkb Signaling Pathway
RESEARCH ARTICLE Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway Shu-Min Chou1†‡, Ke-Xin Li2†, Ming-Yueh Huang3†, Chao Chen2, Yuan-Hung Lin King2,4, Grant Guangnan Li5, Wei Zhou6, Chin Fen Teo2, Yuh Nung Jan2, Lily Yeh Jan2*, Shi-Bing Yang1,7* 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States; 3Institute of Statistics, Academia Sinica, Taipei, Taiwan; 4Neuroscience Graduate Program, University of California, San Francisco, San Francisco, United States; 5Nkarta Therapeutics Inc, South San Francisco, United States; 6Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, United States; 7Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan *For correspondence: Abstract In the postnatal brain, neurogenesis occurs only within a few regions, such as the [email protected] (LYJ); hippocampal sub-granular zone (SGZ). Postnatal neurogenesis is tightly regulated by factors that [email protected] (S-BY) balance stem cell renewal with differentiation, and it gives rise to neurons that participate in †These authors contributed learning and memory formation. The Kv1.1 channel, a voltage-gated potassium channel, was equally to this work previously shown to suppress postnatal neurogenesis in the SGZ in a cell-autonomous manner. In Present address: ‡Program in this study, we have clarified the physiological and molecular mechanisms underlying Kv1.1- Neuroscience and Behavioral dependent postnatal neurogenesis. First, we discovered that the membrane potential of neural Disorders, Duke-National, progenitor cells is highly dynamic during development. -
Detailed Program
PROGRAM MONDAY, April 12—7:30 PM INTRODUCTION David Stewart Cold Spring Harbor Laboratory Maoyen Chi Cold Spring Harbor Asia SESSION 1 KEYNOTE SPEAKERS KEYNOTE I Introduction by Mu-ming Poo Linda Buck Howard Hughes Medical Institute Fred Hutchinson Cancer Research Center “Deconstructing smell” 1 KEYNOTE II Introduction by Z. Josh Huang Karl Deisseroth Stanford University “Optogenetics—Development and application” 2 v TUESDAY, April 13—9:00 AM SESSION 2 NEUROGENESIS Chairperson: Z. Josh Huang, Cold Spring Harbor Laboratory, USA Looking into the developing zebrafish retina William A. Harris. Presenter affiliation: Cambridge University, Cambridge, United Kingdom. 3 Creating the cortex, assembling the amygdala Shubha Tole. Presenter affiliation: Tata Institute of Fundamental Research, Mumbai, India. 4 Temporal regulation of neural stem cell fate in the developing mouse neocortex Yukiko Gotoh, Masafumi Tsuboi, Yusuke Kishi, Nao Suzki, Yusuke Hirabayashi. Presenter affiliation: University of Tokyo, Tokyo, Japan. 5 Regulation of midline glial development by nuclear factor one genes in the cerebral cortex Linda J. Richards. Presenter affiliation: The University of Queensland, Brisbane, Australia. 6 Stimulation of latent, neurogenic precursor pools in the hippocampus by synaptic activity Perry F. Bartlett, Dhanisha Jhaveri, Tara L. Walker. Presenter affiliation: The University of Queensland, Brisbane, Australia. 7 Neurogenesis—Its implication in and application for mental diseases Noriko Osumi. Presenter affiliation: Tohoku University Graduate -
Annual Report 20 12
81833•HFSP-RA-2012_Couv.pdf 07/06/13 11:59 - 1 - ( ) 12 Acknowledgements HFSPO is grateful for the support of: Australia National Health and Medical Research Council (NHMRC) Canada Canadian Institute of Health Research (CIHR) Natural Sciences and Engineering Research Council (NSERC) European Union European Commission - Directorate General for Communications Networks, Contents and Technology (DG CONNECT) ANNUAL REPORT 20 European Commission - Directorate General Research (DG RESEARCH) France Communauté Urbaine de Strasbourg (CUS) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Région Alsace Germany Federal Ministry of Education and Research (BMBF) India Department of Biotechnology (DBT), Ministry of Science and Technology Italy Ministry of Eduction, University and Research (CNR) Japan Ministry for Economy, Trade and Industry (METI) Ministry of Education, Culture, Sports, Science and Technology (MEXT) Republic of Korea Ministry of Science, ICT and Future Planning (MSIP) New Zealand Health Research Council of New Zealand (HRC) Norway Research Council of Norway (RCN) Switzerland State Secretariat for Education, Research and Innovation (SERI) United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) Medical Research Council (MRC) United States of America National Institutes of Health (NIH) National Science Foundation (NSF) The International Human Frontier Science Program Organization (HFSPO) 12 quai Saint Jean - BP 10034 67080 Strasbourg CEDEX - France Fax. +33 (0)3 88 32 88 97 e-mail: [email protected] Web site: www.hfsp.org Japanese web site: http://jhfsp.jsf.or.jp 81833•HFSP-RA-2012_Couv.pdf 07/06/13 11:59 - 2 - ( ) HUMAN FRONTIER SCIENCE PROGRAM The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontier of the life sciences. -
Neurobiologists Lily Jan, Phd, and Yuh Nung Jan, Phd, to Receive the $500,000 Gruber Neuroscience Prize for Fundamental Contributions to Molecular Neurobiology
Media Contact: A. Sarah Hreha +1 (212) 247-8484 [email protected] Online Newsroom: www.gruberprizes.org/Press.php FOR IMMEDIATE RELEASE Neurobiologists Lily Jan, PhD, and Yuh Nung Jan, PhD, to Receive the $500,000 Gruber Neuroscience Prize for Fundamental Contributions to Molecular Neurobiology June 12, 2012, New York, NY – Lily Jan, PhD, and Yuh Nung Jan, PhD, of the Howard Hughes Medical Institute and the University of California, San Francisco, will jointly receive the 2012 Neuroscience Prize of The Gruber Foundation. They are being recognized for their fundamental contributions to the field of molecular neurobiology, particularly their pioneering work on how potassium channels control brain cell activity and on how brain cells diversify and specialize during embryonic development. Lily Jan Yuh Nung Jan The Jans have mentored and inspired a large number of students and postdoctoral fellows, many of whom now serve as faculty at major universities and research institutions in the United States and throughout the world. They will receive the award October 14 in New Orleans at the Annual Meeting of the Society for Neuroscience and will deliver a lecture titled “In search of molecular underpinnings of neuronal morphologies and function: from Drosophila neurogenetics to evolutionarily conserved machineries in mammals." “The Jans’ discoveries of fundamental mechanisms of potassium channel function in health and disease, combined with their genetic dissection of dendritic development in animals has built a scaffold for understanding the intricacies of neuron development and function,” says Carol Barnes, chair of the Selection Advisory Board to the Neuroscience Prize. Lily Jan and Yuh Nung Jan began to collaborate on their research soon after they finished graduate school in 1974. -
Highly Cited Researchers (H>100) According to Their Google Scholar
Highly Cited Researchers (h>100) according to their Google Scholar Citations public profiles H- RANK NAME ORGANIZATION CITATIONS INDEX 1 Sigmund Freud University of Vienna 269 488396 2 Graham Colditz Washington University in St Louis 264 256415 3 Eugene Braunwald Brigham and Women’s Hospital; Harvard Medical School 246 290831 4 Ronald C Kessler Harvard University 245 263006 5 Pierre Bourdieu Centre de Sociologie Européenne; Collège de France 242 528228 7 Solomon H Snyder Johns Hopkins University 240 216313 6 Michel Foucault Collège de France 237 690001 8 Robert Langer Massachusetts Institute of Technology MIT 232 216122 9 Bert Vogelstein Johns Hopkins University 230 315600 10 Eric Lander Broad Institute Harvard MIT 225 294683 11 Michael Karin University of California San Diego 223 210430 12 Gordon Guyatt McMaster University 217 187432 13 Michael Graetzel Ecole Polytechnique Fédérale de Lausanne 216 235390 14 Salim Yusuf McMaster University 214 248236 15 Richard A Flavell Yale University; HHMI 214 171241 16 Frank B Hu Harvard University 206 158298 17 T W Robbins University of Cambridge 206 130965 18 Carlo Croce Ohio State University 203 181398 19 Peter Barnes Imperial College London 202 178101 20 Eric Topol Scripps Research Institute 200 178348 21 A S Fauci National Institutes of Health NIH 200 168338 22 Chris Frith University College London 200 152183 23 Steven A Rosenberg National Cancer Institute NIH 199 164925 24 Kenneth Kinzler Johns Hopkins University 198 206590 25 Matthias Mann # Max Planck Gesellschaft MPG 196 175332 26 Karl Friston -
Cold Spring Harbor Summer Courses and Drosophila Melanogaster Neurogenetics Lily Yeh Jan and Yuh Nung Jan
ESSAY JGP 100th Anniversary Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics Lily Yeh Jan and Yuh Nung Jan In the fall of 1968, we arrived at the California Institute of Technology (Caltech) to start graduate studies in theoretical high-energy physics, realizing a dream that we’d held since our undergraduate days in Taiwan. But after a couple of years studying physics, we were inspired by Max Delbrück to switch to biology. Thereafter began a journey that took us to Cold Spring Harbor Laboratory and Harvard Medical School before returning to California, where we started our little laboratory in the Department of Physiology at the University of California at San Francisco (UCSF) in 1979. These formative years spent as students and postdocs had a strong influence on our careers that continues to inspire our scientific direction and approach. Our first few days at Caltech were disorienting. Besides the cultural shock, we faced our first experience of jet lag, having never traveled beyond a time zone previously. However, we soon Research interests scribbled by Seymour Benzer on the lunchroom blackboard, settled, and while graduate students in Max Delbrück’s labora- circa 1975. Placed at the bottom of the blackboard is a group photo of the Benzer tory, we benefitted from the nearly annual trip to Cold Spring lab at that time. Lab members at one lunch session brought up scientific ques- Harbor Laboratory, where Max liked to spend the summer. We tions that interested them the most. Listed below is what we could decipher from the writing on the blackboard, starting from the upper left corner and ending at enjoyed the relaxed atmosphere and stimulating activities in and the lower right corner: “Behavior (whole animal psychology, ethology): social out of the laboratory at Cold Spring Harbor. -
BK-SFN-NEUROSCIENCE-131211-04 Lily-And-Yuh-Nung.Indd 144 16/04/14 5:21 PM Yuh-Nung Jan
BK-SFN-NEUROSCIENCE-131211-04_Lily-and-Yuh-nung.indd 144 16/04/14 5:21 PM Yuh-Nung Jan BORN: Shanghai, China December 20, 1946 EDUCATION: National Taiwan University, BS (1967) California Institute of Technology, PhD (1974) APPOINTMENTS: Postdoctoral Research Fellow, California Institute of Technology (1974) Postdoctoral Research Fellow, Harvard Medical School (1977) Assistant Professor, University of California, San Francisco (1979) Investigator, Howard Hughes Medical Institute (1984) HONORS AND AWARDS (SELECTED): McKnight Scholar Award (1978–1981) Elected member, National Academy of Sciences (1996) Elected member, Academia Sinica, Taiwan (1998) Distinguished Alumni Award, California Institute of Technology (2006) Elected member, American Academy of Arts and Sciences (2007) Javits Neuroscience Investigator Award, National Institute of Neurological Disorders and Stroke, National Institutes of Health (2010) Seymour Benzer Lecture, Neurobiology of Drosophila meeting, Cold Spring Harbor Lab (2011) HONORS AND AWARDS SHARED BY LILY JAN AND YUH-NUNG JAN: W. Alden Spencer Award and Lectureship, Columbia University (1988) 38th Faculty Lecturer Award, University of California, San Francisco (1995) Harvey Lecture, New York (1998) The Stephen W. Kuffler Lecture, Harvard Medical School (1999) K. S. Cole Award, Biophysical Society (2004) Jan Lab Symposium (2006) Society of Chinese Bioscientists in America Presidential Award (2006) Ralph Gerard Prize, Society for Neuroscience (2009) Edward M. Scolnick Prize in Neuroscience, Massachusetts Institute of -
Women Scientists: Reflections, Challenges, and Breaking Boundaries
Women Scientists Also by the Author Great Minds: Reflections of 111 Top Scientists (Oxford University Press, 2014, with B. Hargittai and I. Hargittai) Symmetry through the Eyes of a Chemist 3rd edition (Springer, 2009, with I. Hargittai) Visual Symmetry (World Scientific, 2009, with I. Hargittai) Candid Science IV, VI: Conversations with Famous Scientists (Imperial College Press, 2004, 2006, with I. Hargittai) In Our Own Image: Personal Symmetry in Discovery (Plenum/Kluwer, 2000; Springer, 2012; with I. Hargittai) Symmetry: A Unifying Concept (Shelter Publications, 1994, with I. Hargittai) Cooking the Hungarian Way, 2nd edition (Lerner, 2002) The Molecular Geometry of Coordination Compounds in the Vapor Phase (Elsevier, 1977, with I. Hargittai) Edited Volumes Candid Science I, II, III: Conversations with Famous Scientists (Imperial College Press, 2000–2003, with I. Hargittai) Advances in Molecular Structure Research, Vols. 1–6 (JAI Press, 1995–2000, with I. Hargittai) Stereochemical Applications of Gas-Phase Electron Diffraction, Parts A and B (VCH, 1988, with I. Hargittai) Women Scientists Reflections, Challenges, and Breaking Boundaries Magdolna Hargittai 1 1 Oxford University Press is a department of the University of Oxford. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Oxford New York Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi New Delhi Shanghai Taipei Toronto With offices in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan Poland Portugal Singapore South Korea Switzerland Thailand Turkey Ukraine Vietnam Oxford is a registered trademark of Oxford University Press in the UK and certain other countries.