ADAMTS4 Antibody Cat. No.: 29-597

ADAMTS4 Antibody

Antibody used in IHC on Human Kidney at 4.0-8.0 ug/ml.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human ADAMTS4.

TESTED APPLICATIONS: ELISA, IHC, WB

ADAMTS4 antibody can be used for detection of ADAMTS4 by ELISA at 1:62500. ADAMTS4 APPLICATIONS: antibody can be used for detection of ADAMTS4 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. 1211 - HepG2 Cell Lysate

PREDICTED MOLECULAR 37 kDa, 90 kDa WEIGHT:

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PURIFICATION: Antibody is purified by peptide affinity chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: ADAMTS4 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: ADAMTS4

ALTERNATE NAMES: ADAMTS4, ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688

ACCESSION NO.: AAH30812

PROTEIN GI NO.: 21410063

GENE ID: 9507

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

ADAMTS4 is a member of the ADAMTS (a and with motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal BACKGROUND: domains. ADAMTS4 lacks a C-terminal TS motif. It is responsible for the degradation of , a major of , and , a -specific protein. The cleavage of aggrecan and brevican suggests key roles of this in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

ANTIBODIES FOR RESEARCH USE ONLY.

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