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10 Top Researchers at AECOM
TEN LEADING EINSTEIN RESEARCHERS AND THEIR ACCOMPLISHMENTS INFECTIOUS DISEASE John Blanchard, Ph.D., has identified a promising new treatment for extensively drug-resistant tuberculosis (XDR-TB), a dangerous form of the disease caused by strains of TB bacteria that have become resistant to virtually all antibiotics. In 2009, Dr. Blanchard reported that a combination of two drugs (clavulanate and meropenem) was highly effective in halting the growth of XDR-TB in John Blanchard, Ph.D. John Condeelis, Ph.D. Ekaterina Dadachova, Ph.D. laboratory culture. Since then, his drug combination has saved the lives of several patients with XDR-TB and will soon be formally evaluated in two human trials, in South Africa and Belgium. Dr. Blanchard is professor of biochemistry and the Dan Danciger Professor of Biochemistry. Arturo Casadevall, M.D., Ph.D., is one of the world’s leading microbiologists, well known for his diverse and innovative scientific inquiries. His work on Arturo Casadevall, M.D., Ph.D Vern Schramm, Ph.D. Joseph Sparano, M.D. fungal melanin, for example, has opened up the possibility of using this pigment in novel CANCER ways to protect against radiation exposure. Thanks to a highly John Condeelis, Ph.D., anatomy and structural biology Casadevall, M.D., Ph.D., Dr. productive research partnership is a leading expert on imaging department, scientific director of Dadachova developed radio- with colleague Ekaterina the tumor microenvironment— the analytical imaging facility, immunotherapy for metastatic Dadachova, Ph.D., he has the microscopic site where tumor co-director of the Gruss Lipper melanoma—a treatment developed a targeted therapy cells interact with surrounding Biophotonics Center, and the strategy that has shown promise for metastatic melanoma that cells. -
NASA's Planetary Science Lunar Activities and Plans
NASA Lunar Science Activities James L. Green Planetary Science Division NASA Headquarters Washington DC 20546 [email protected] NASA’s Planetary Science Division (PSD) program encompasses a broad range of missions to many destinations in the solar system but the Earth’s Moon holds a special place in these efforts. Our planetary science missions are either strategic or openly competed through announcements of opportunity and are led by a principal investigator (PI). In exploring any particular solar system object, NASA has followed a general paradigm of “flyby, orbit, land, rove, and return.” This prescription has been followed most completely for investigations of the Moon and Mars. The Exploration Systems Mission Directorate (ESMD) will be launching the Lunar Reconnaissance Orbiter (LRO) in 2008 in preparation for manned missions to the Moon. LRO is a strategic mission with competed instrumentation to support exploration goals. After one year of LRO observations, ESMD will transition the spacecraft operations to the PSD for its prime science mission phase. The two competitive PI mission lines in the Planetary Science Division are called Discovery and New Frontiers, both of which have the potential to support Lunar missions. Currently there are three Phase-A studies in competition in the Discovery program which includes the Gravity Recovery and Interior Laboratory (GRAIL) mission by Maria Zuber (PI), MIT. The down-selection for Discovery will be announced later this year. GRAIL proposes to use high-quality gravity field mapping of the Moon to determine its interior structure. The New Frontiers program will next be in competition by late 2008 providing a potential opportunity for a sample return mission from the South Pole-Aitken basin. -
The 24 Million Km Link with the Mercury Laser Altimeter
Te 24 Milion Km Link wit te Mercury Laser Altmetr Jay Steigelman Dave Skillman Barry Coyle John F. Cavanaugh Jan F. McGarry Gregory A. Neumann Xiaoli Sun Thomas W. Zagwodzki Dave Smith Maria Zuber MOLA Science Team Meeting Bishop’s Lodge, Santa Fe, NM August 24-25, 2005 Test Objectives Messenger: MErcury Surface, Space ENvironment, GEochemistry and Ranging 6.6 year travel time to Mercury... There’s not a whole lot to do during this time. Dave Smith called a meeting and asked, “What about a transponder experiment?” Official goals were: ➡ Verify laser performance; verify laser pointing and receiver boresight with respect to MESSENGER spacecraft coordinates. ➡ Verify MLA ranging function and performance using a ground laser to simulate backscattered pulses. ➡ Calibrate MLA boresight offset with Mercury Dual Image System (MDIS). Recent Publications BREVIA the received pulse shapes. Sixteen consecutive pulses were recorded at 19:47:24 UTC on 27 and 24 May; more were recorded at 19:42:02 Two-Way Laser Link over UTC on 31 May. Simultaneously, a laser at GGAO was beamed upward toward MLA. The uplink pulses, along Interplanetary Distance with noise triggers from the sunlit Earth, were received within a 15-ms range window during David E. Smith,1* Maria T. Zuber,1,2 Xiaoli Sun,1 Gregory A. Neumann,1,2 1 1 1 each 125-ms shot interval. Inspection of the John F. Cavanaugh, Jan F. McGarry, Thomas W. Zagwodzki stored instrument data revealed 90 pulses over a 30-min time frame, 17 on multiple channels, he detection and precise timing of low- Geophysical and Astronomical Observatory whose timing matched the GGAO fire times. -
Antibodies and Fungi: an Evolving Paradigm with Opportunities for the Development of New Antifungal Therapies and Vaccines
2 Rev Iberoam Micol 1997; 14: 2-3 Forum Micológico Antibodies and fungi: an evolving paradigm with opportunities for the development of new antifungal therapies and vaccines Arturo Casadevall Departments of Medicine (Division of Infectious Diseases) and Microbiology & Immunology of the Albert Einstein College of Medicine, Bronx, New York, USA The role of antibody immunity in protection with the function of protective antibodies [8]. Hence there against fungal infections has been uncertain for decades. is now evidence for "good" and "bad" antibodies against This is in sharp contrast to bacteria, viruses, and protozoa fungi. where antibody immunity is widely acknowledged to con- Protection studies with mAbs suggest an explana- tribute to protection. This raises the questions: Do protec- tion for the inconclusive and often contradictory results tive antibodies against fungi exist?; Why has it been so obtained from experiments with polyclonal sera [2]. difficult to demonstrate conclusively that antibody immu- Polyclonal antibody preparations contain antibodies of nity protects against fungi?; Does antibody immunity multiple specificities and isotypes. MAb preparations dif- influence the course of fungal infections? fer from polyclonal antibodv preparations in that they The issue of whether antibody immunity contribu- contain one antibody type of a defined specificity and tes to host defense against fungi is no longer academic. In isotype. The discovery that protective, non-protective and recent years there has been a marked increase in fungal deleterious mAbs exist suggests that the efficacy of poly- infections associated with the HIV epidemic and immuno- clonal antibody preparations reflects their relative propor- suppressive therapies. Systemic mycoses in immunocom- tion of these types of antibodies. -
2018 Resources Seminar Slides.Pdf
Special Seminar 21 September 2018 Resources and Opportunities Johns Hopkins Malaria Research Institute Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Connection with MMI Since 2001 Bloomberg Philanthropies has given $125 million to the Bloomberg School to fund a state-of-the-art research facility to mount a broad program of basic-science research to treat and control malaria, develop a vaccine and find new drug targets to prevent and cure this deadly disease. Diane Griffin, MD, PhD Founding Director, JHMRI Former Chair, MMI Dept The Institute resides in the Department of Molecular Microbiology and Immunology (MMI). Arturo Casadevall, MD, PhD Current Chair, MMI Dept 2 Leadership George Dimopoulos, PhD, MBA Bill Moss, MD, MPH Professor, JHMRI Deputy Director, Professor, JHMRI Deputy Director, Parasite Core Director & ICEMR Program Director Peter Agre, MD Bloomberg Distinguished Professor & JHMRI Director Sean Prigge, PhD Photini Sinnis, MD Professor, JHMRI Deputy Director, Professor & JHMRI Deputy & Co-Director Biophysics Core Director 3 21 Faculty/Labs Core Facilities School of Public Health • Insectary – Molecular Microbiology • Parasite Core & Immunology • Biophysics Core – Epidemiology • Spatial Science Core • MMI Genetic Analysis & School of Medicine Sequencing Facility Cell Biology – • MMI Imaging & Microscopy – Neuroscience • MMI Flow Cytometry/Cell – Pharmacology Sorting Core Field Site Macha, Zambia 4 Macha Research Trust Southern Province, Zambia Field station in rural Zambia Molecular laboratory Insectary Malaria “sphere” Flight cage 5 JHBSPH Staff Based in Macha Dr. Phil Thuma, MD Dr. Jennifer Stevenson, PhD Senior Scientific advisor Lead Entomologist 6 3 Biophysics Core Facility Co-Directors Scott Bailey, PhD Email: [email protected] Sean Prigge, PhD Email: [email protected] Biophysics Core Johns Hopkins Bloomberg School of Public Health 615 N. -
Reconstructing the History of El Niño from Galapagos Lakes Julian Sachs and Rienk Smittenberg
Also in this issue: 3 MER Experience 5 The Journey To The Deep Interior Of The Earth From MIT 10 Seminar Honors Nafi Toksoz EAPSpeaks Earth, Atmospheric and Planetary Sciences Massachusetts Institute of Technology Reconstructing the History of El Niño from Galapagos Lakes Julian Sachs and Rienk Smittenberg The largest perturbation to global climate on an inter- cial conditions. Focusing on Holocene variability of ENSO annual time scale is the El Niño-Southern Oscillation provides a similarly contradictory set of conclusions. (ENSO). Surface water temperatures (SST) rise in the Straddling 0° latitude in the cold tongue of the EEP, Eastern Equatorial Pacifi c (EEP) when the upwelling of the Galapagos are ideally positioned to record varia- cool, nutrient-rich water diminishes. Fish stocks plum- tions in ENSO through time. Lakes on the islands serve met and birds and mammals perish, causing widespread as fi xed sampling stations of the eastern Pacifi c marine ecologic and economic disruptions. Global precipitation climate. Aridity of the Galapagos is caused by the atmo- patterns are altered, causing drought in normally wet spheric inversion that results from upwelling of cold wa- locations and torrential rains in desert regions. Will El ter. This prevents the establishment of convection cells that should otherwise bring rain to a tropical oceanic island. Only in the December to February period, when the “meteorological equator” moves to its most souther- ly position, does the inversion collapse, bringing rain. In some years, however, the encroachment of surface water from the west thickens the surface layer and removes deeper cold water from the upwelling system, SSTs rise, intensifying tropical convection cells. -
Co-Sponsored by College of Sciences PROFESSOR MARIA ZUBER E.A
The Georgia Tech Center for the Study of Women, Science, & Technology (WST) Presents 2019 WST DISTINGUISHED LECTURER Co-sponsored by College of Sciences PROFESSOR MARIA ZUBER E.A. Griswold Professor of Geophysics Vice President for Research Massachusetts Institute of Technology "Advancing Gender Equity Across the Solar System" 4:00 pm, Tuesday, April 2, 2019 Clary Theatre, Bill Moore Student Success Center Dr. Maria Zuber is the E.A. Griswold Professor of Geophysics and Vice President for Research at Massachusetts Institute of Technology (MIT), where she is responsible for research administration and policy. She oversees the MIT Lincoln Laboratory and more than a dozen interdisciplinary research laboratories and centers. Dr. Zuber's research bridges planetary geophysics and the technology of space- based laser and radio systems. Since 1990, she has held leadership roles with scientific experiments or instrumentation on ten NASA missions, mapping the Moon, Mars, Mercury, and several asteroids. Notably, she was Principal Investigator of the Gravity Recovery and Interior Laboratory or GRAIL mission. Her numerous awards include the MIT James R. Killian Jr. Faculty Achievement Award, the highest honor the MIT bestows to its faculty. She is a member of the National Academy of Sciences and American Philosophical Society, and is a fellow for the American Academy of Arts and Sciences, the American Association for the Advancement of Science, the Geological Society, and the American Geophysical Union. Dr. Zuber is the first woman to lead a science department at MIT, and the first to lead a NASA planetary mission. In 2013, President Obama appointed her to the National Science Board, and in 2018 she was reappointed by President Trump. -
Mapping the Topography of Mercury with MESSENGER Laser Altimetry | SPIE Newsroom: SPIE 11/2/12 11:23 PM
Mapping the topography of Mercury with MESSENGER laser altimetry | SPIE Newsroom: SPIE 11/2/12 11:23 PM CREATE AN ACCOUNT | SIGN IN ABOUT SPIE | CONTACT US | HELP | SHOPPING CART SEARCH HOME CONFERENCES + EXHIBITIONS PUBLICATIONS EDUCATION MEMBERSHIP INDUSTRY RESOURCES CAREER CENTER NEWS + VIDEOS Newsroom Home Astronomy Astronomy Biomedical Optics & Medical Imaging Mapping the topography of Mercury with MESSENGER laser altimetry Defense & Security Xiaoli Sun, John Cavanaugh, Gregory Neumann, David Smith and Maria Zuber Electronic Imaging & Signal The Mercury Laser Altimeter onboard MESSENGER involves unique design Processing elements that deal with the challenges of being in orbit around Mercury. 26 October 2012, SPIE Newsroom. DOI: 10.1117/2.1201210.004489 Illumination & Displays The Mercury Laser Altimeter (MLA) is one of seven instruments on NASA's MErcury Surface, Space Lasers & Sources ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. MESSENGER was launched on 3 August 2004, and entered into orbit Micro/Nano Lithography about Mercury on 18 March 2011 after a journey through the inner solar system. This involved six Nanotechnology planetary flybys, including three of Mercury. MLA is designed to map the topography and landforms of Mercury's surface. It also measures the planet's forced libration (motion about the spin axis), which Optical Design & Engineering helps constrain the state of the core. The first science measurements from orbit taken with MLA were made on 29 March 2011 and continue to date. MLA had accumulated about 8.3 million laser ranging measurements to Optoelectronics & Mercury's surface, as of 31 July 2012, i.e., over six Mercury years (528 Communications Earth days). Outer space Remote Sensing exploration Although MLA is the third planetary lidar built at the NASA Goddard Space Earn an Aerospace Flight Center (GSFC), MLA must endure a much harsher thermal degree online at environment near Mercury than the previous instruments on Mars and Earth American Public Sensing & Measurement University System. -
Biden's Science Policy
www.rsis.edu.sg No. 013 – 22 January 2021 RSIS Commentary is a platform to provide timely and, where appropriate, policy-relevant commentary and analysis of topical and contemporary issues. The authors’ views are their own and do not represent the official position of the S. Rajaratnam School of International Studies, NTU. These commentaries may be reproduced with prior permission from RSIS and due recognition to the author(s) and RSIS. Please email to Mr Yang Razali Kassim, Editor RSIS Commentary at [email protected]. The Biden Presidency Biden’s Science Policy: U-Turn from Trump By Cung Vu SYNOPSIS President Biden has announced his nomination of Eric Lander as his chief science advisor and director of the Office of Science and Technology Policy (OSTP) and at the same time elevated this dual-hatted position to a Cabinet rank. This reflects the desire of the new administration to give science a prominent role to guide its strategy and policy. COMMENTARY ON 15 JANUARY 2021, President Joe Biden announced his Science Advisor Team, underscoring the new administration’s policy of being guided by "science, facts and truth". Biden nominated Eric Lander as his chief science advisor and director of the Office of Science and Technology Policy (OSTP). Lander is a mathematician and geneticist who helped map the human genome as well as president and founding director of the Broad Institute jointly run by Harvard University and the Massachusetts Institute of Technology. At the same time Biden elevated this dual-hatted position to cabinet level. Biden also appointed a Princeton social scientist Alondra Nelson as the deputy chief science advisor. -
Overview Newsletter
Department of Earth and Planetary Sciences Newsletter Fall 2009 Issue 9 Overview IN THIS ISSUE... Greetings from the Department of Earth and Planetary Sciences at Wash- ington University! These are exciting times in the department, as the recent influx of new faculty members and their laboratory equipment are Overview rapidly filling up the new building that we began to occupy in 2004. For Colorado Plateau Trip the first time since at least 1991, we have four assistant professors in the Arvidson Steps Down department (Jeff Catalano, Fred Moynier, David Fike, and Phil Skemer). Wiens New Chairman Fred and Phil are profiled in this issue, and Jeff and David were profiled in the 2007 issue. All of the junior faculty are making excellent progress, Current Research as evidenced by the fact that all have already obtained NSF and/or NASA Virtual Reality Lab funding for their research. Further good news is that Jennifer Smith is no longer an assistant Mineral-Water professor, as she was promoted to associate professor with tenure this summer. Finally, we Interface have also been joined by lecturer Vali Memeti (also profiled inside), who is providing much- needed help in teaching several geology courses. Phoenix Mission As you can see, the department also has a new chairman. Ray Arvidson stepped down EPSc In Action last summer after 17 very successful years leading the department. I agreed to become the Department News new chair, and while it will be impossible to truly replace Ray, I am highly optimistic that we can continue our up- New Faculty ward trajectory in the years E & PS Faculty ahead. -
Maria T. Zuber Vice President for Research Office of the Vice President for Research
Maria T. Zuber Vice President for Research Office of the Vice President for Research [email protected] (617) 253-3206 3-234 http://orgchart.mit.edu/vice-president-research Maria Zuber is the E. A. Griswold Professor of Geophysics and Vice President for Research at MIT, where she is responsible for research administration and policy. She oversees MIT Lincoln Laboratory and more than a dozen interdisciplinary research laboratories and centers, including the Koch Institute for Integrative Cancer Research, the MIT Energy and Environmental Solutions Initiatives, the Plasma Science and Fusion Center, the Research Laboratory of Electronics, the Materials Research Laboratory, MIT.nano and Haystack Observatory. She also oversees Fast Forward, MIT’s Climate Action Plan for the Decade. Vice President Zuber is responsible for intellectual property, and research integrity and compliance, as well as research relationships with the federal government. She serves as the senior officer responsible for the Institute’s postdoctoral scholars and research staff. Zuber’s research bridges planetary geophysics and the technology of space-based laser and radio systems. Since 1990, she has held leadership roles associated with scientific experiments or instrumentation on ten NASA missions, most notably serving as Principal Investigator of the Gravity Recovery and Interior Laboratory or GRAIL mission. She currently serves as Chair of the Standing Review Board of NASA’s Mars Sample Return mission. Zuber has won numerous awards including the MIT James R. Killian Jr. Faculty Achievement Award, the highest honor the MIT faculty bestows to one of its own. She is a member of the National Academy of Sciences and American Philosophical Society and is a fellow of the American Academy of Arts and Sciences, the American Association for the Advancement of Science, the Geological Society of America and the American Geophysical Union, and an honorary fellow of the Royal Astronomical Society. -
Bldg. 21 Rm 121 Email: [email protected] Mail To: PO Box 6010, Flagstaff, AZ 86011
JENNIFER BUZ Department of Physics and Astronomy, Northern Arizona University Office: Bldg. 21 Rm 121 Email: [email protected] Mail to: PO Box 6010, Flagstaff, AZ 86011 EMPLOYMENT Postdoctoral Researcher, Dept. of Physics and Astronomy, NAU, 06/18-present EDUCATION Ph.D., Geological Sciences, California Institute of Technology, 2018 S.M., Planetary Sciences, Massachusetts Institute of Technology, 2011 S.B., Geological and Planetary Sciences, Massachusetts Institute of Technology, 2010 PROFESSIONAL & MISSION EXPERIENCE NASA Earth and Space Science Fellowship Recipient, 2015, 2016, 2017 Using remote sensing, laboratory, and in-situ measurements to understand the bedrock geology and past environments in the greater Gale region, Mars NASA Exobiology Grant collaborator, 2015-Present Application of New Paleomagnetic and Rock Magnetic Techniques to Test the Origin of Magnetite in ALH84001 Carbonate Mars Science Laboratory, Science Team Member, Caltech/JPL, 3/14-Present Caltech Seismological Laboratory, Data Analyst, 10/11-12/12 Lunar Orbiter Laser Altimeter, Research Assistant for Maria Zuber, NASA Goddard, 1/10-9/10 Surface roughness calculations and comparison with neutron detections Lunar and Planetary Institute, Intern for Patrick McGovern, 6/09-8/09 Investigating Venusian volcano edifice shape using radar data Paleomagnetism Laboratory, Research Assistant for Ben Weiss, MIT, 2008-2010 TEACHING EXPERIENCE Teaching Assistant, Paleomagnetism and Magnetostratigraphy (CIT Ge124a/b), 2015, 2017 Teaching Assistant, Field Geology Summer Field