PROGRAM 16 International Symposium on Bioinformatics Research and Applications (ISBRA) 1-4 December 2020, Moscow Tuesday, December 1st, 2020

16.00-17.00 Joining the online conference. Introduction to the technical information Hall Pirogov 17.00-17.30 Symposium Opening and Welcome Hall Pirogov 17.30-18.30 Plenary Session Chair: Pavel Skums, Georgia State University, Atlanta, USA Keynote Talk 1 Genome graphs: Models, Algorithms, and Applications 17.30-18.30 Srinivas Aluru, School of Computational Science and Engineering Executive Director, Institute for Data Engineering and Science Georgia Institute of Technology, USA

18.30-18.40 Break Hall Pirogov Session 1A: 18.40-20.20 Phylogeny

Pavel Skums, Georgia State University, Atlanta, USA Chairs:

Testing the agreement of trees with internal labels 18.40-19.00 David Fernández-Baca, Lei Liu Iowa State University, Ames, United States

Checking phylogenetic decisiveness in theory and in practice Ghazaleh Parvini, Katherine Braught, David Fernández-Baca Iowa State University, Ames, United States 19.00-19.20 TNet: Phylogeny-based inference of disease transmission networks using within-host strain diversity Saurav Dhar, Chengchen Zhang, Ion Mandoiu, Mukul S. Bansal 19.20-19.40 University of Connecticut, Storrs, United States Statistical evidence for the presence of trajectory in single-cell data Lovemore Tenha, Mingzhou Song New Mexico State University, Las Cruces, New Mexico, 19.40-20.00 United States

SC1: interactive web-based single cell RNA-seq analysis 20.00-20.20 Marmar Moussa, Ion Mandoiu University of Connecticut, Storrs, United States PROGRAM 16 International Symposium on Bioinformatics Research and Applications (ISBRA) 1-4 December 2020, Moscow

Wednesday, December 2nd, 2020 8.00-09.00 Joining the online conference. Introduction to the technical information (for online participants) Hall Pirogov 9.00-10.00 Plenary Session Chair: Ion Mandoiu, University of Connecticut, Storrs, USA

Keynote Talk 2 9.00-10.00 TDA on Big Data Omics Laxmi Parida, Computational Biology Center, IBM Thomas J. Watson Research Center, New York, USA

Hall Pirogov Abrikosov Parallel Sessions 10.00-11.40 Session 2A: Session 2B: Learning Applications Sequencing Data Analysis Chairs: TBA Ion Mandoiu, University of Connecticut, Storrs, USA SemiTCR: A semi-supervised learning framework for classifying TCR Mitochondrial haplogroup assignment for high-throughput sequencing data from sequences single individual and mixed DNA samples 10.00-10.20 Haodong Bian, Jiayin Wang, Tian Zheng, Xuanping Zhang Fahad Alqahtani, Ion Mandoiu Xi'an Jiaotong University, Xi'an, Shaanxi, China University of Connecticut, Storrs, United States Recurrent neural networks for DNA folding characteristics mapAlign: an efficient approach for mapping and aligning long reads to reference Michal Rozenwald, Aleksandra Galitsyna, Mikhail Gelfand genomes 10.20-10.40 National Research University Higher School of Economics, Moscow, Russia Lusheng Wang, Wen Yang Skolkovo Institute of Science and Technology, Moscow, Russia City University of Hong Kong, Hong Kong

Drug response prediction using Learning Graph Representation with SVLR: Genome structure variant detection using long read sequencing data Laplacian Feature Selection Wenyan Gu, Aizhong Zhou, Lusheng Wang, Xuefeng Cui, Daming Zhu 10.40-11.00 Guijin Li, Jianxing Ouyang, Minzhu Xie School of Computer Science and Technology, Shandong University, Shandong, China Hunan Normal University, Changsha, Hunan, China City University of Hong Kong, Hong Kong

Learning structural genetic information via graph neural embedding Yuan Xie, Yulong Pei, Yun Lu, Haixu Tang, Yuan Zhou Detecting genomic deletions from high-throughput sequence data with Indiana University Bloomington, Bloomington, United States unsupervised learning 11.00-11.20 Eindhoven University of Technology, Eindhoven, Netherlands Xin Li, Yufeng Wu Peking University, Beijing, China University of Connecticut, Storrs, United States University of Illinois Urbana-Champaign, Urbana, Champaign, United States

Building Forensic Reference Database of Belarusian Population from NGS data 11.20-11.40 Discussion Roman Sergeev, Viktar Liakhouski, Anna Hadarovich, Grigory Nikolaev, Svetlana Kotova, Elena Spivak, Iosif Tsybovsky United Institute of Informatics Problems, Minsk, Belarus 11.40-12.00 Break Hall Pirogov Abrikosov Parallel Sessions 12.00-13.00 Session 3A: Session 3B: Metagenomics Viral Models Alexander Tuzikov, United Institute of Informatics Problems, National Academy of Chairs: TBA Sciences of Belarus In silico-guided discovery of potential HIV-1 entry inhibitors mimicking bNAb N6: virtual screening, docking, molecular dynamics, and post-molecular modeling analysis Improving Metagenomic Classification using discriminative k-mers Alexander Andrianov, Grigory Nikolaev, Yuri Kornoushenko, Anna Karpenko, Ivan from sequencing data 12.00-12.20 Bosko, Alexander Tuzikov Davide Storato, Matteo Comin Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, University of Padova, Padua, Italy Belarus United Institute of Informatics Problems, National Academy of Sciences of Belarus, Minsk, Russia Deep Ensemble models for 16S Ribosomal Gene Classification Flavonoids as potential inhibitors of the SARS-CoV-2 main protease: molecular Heta Desai, Anuja Parameshwaran, Rajshekhar Sunderraman and docking and virtual screening study 12.20-12.40 Michael Weeks Amir Kh. Taldaev, Roman P. Terekhov, Irina A. Selivanova Georgia State University, Atlanta, United States Sechenov University, Moscow, Russia Development of a neural network-based approach for prediction of potential HIV-1 Estimating enzyme participation in metabolic pathways for microbial entry inhibitors using Deep Learning and molecular modeling methods communities from RNA-seq data Grigory Nikolaev, Nikita Shuldov, Arseny Anishenko, Alexander Tuzikov, 12.40-13.00 Filipp Rondel, Roya Hosseini, Bikram Sahoo, Sergey Knyazev, Alex Alexander Andrianov Zelikovsky United Institute of Informatics Problems of the National Academy of Sciences of Georgia State University, Atlanta, United States Belarus, Belorussian State University, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk, Belarus 13.00-13.30 Break Hall Pirogov Abrikosov Parallel Sessions 13.30-15.10 Session 4A: Session 4B: Drug Design Regulation & Functions Chairs: Yuri Porozov, Sechenov University, Moscow, Russia TBA In silico design and evaluation of novel triazole-based compounds as promising drug candidates against breast cancer Improving prediction of core transcription factors for cell reprogramming and Alexander Andrianov, Grigory Nikolaev, Yuri Kornoushenko, Sergei transdifferentiation 13.30-13.50 Usanov Mikhail Raevskiy, Yulia Medvedeva United Institute of Informatics Problems of the National Academy of Sciences Moscow Institute of Physics and Technology, Dolgoprudny, Russia of Belarus, Minsk, Belarus Na/K-ATPase glutathionylation: in silico modeling of reaction mechanisms Yaroslav Solovev, Daria Ostroverkhova, Gaik Tamazian, Anton Domnin, Anastasya Anashkina, Irina Petrushanko, Eugene Stepanov, Yuri Porozov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia Prediction of LncRNA functions using deep neural networks based on multiple Sechenov University, Moscow, Russia, networks Lomonosov Moscow State University, Moscow, Russia 13.50-14.10 Lei Deng, Shengli Ren, Jingpu Zhang Theodosius Dobzhansky Center for Genome Bioinformatics, Saint Petersburg, Central South University, Changsha, China Russia Henan University of Urban Construction, Pingdingshan, China TheoMAT Group, Saint Petersburg National Research University of Information Technologies, Mechanics and Optic, Saint Petersburg, Russia Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia Steklov Mathematical Institute, Higher School of Economics, St. Petersburg State University, Saint Petersburg, Russia

Balance between reaction stages is crucial for the design of paraoxonase activity in butyrylcholinesterase Non-coding RNA-directed gene activation in tuberculosis Alexander Zlobin, Olga Makarikova, Andrey Golovin 14.10-14.30 Anna Elizarova, Yulia Medvedeva Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Sirius Federal Research Centre “Fundamentals of Biotechnology” of RAS, Moscow, Russia University of Science and Technology, Sochi, Russia Lomonosov Moscow State University, Moscow, Russia A database of experimentally validate protocols for chemical compound- Enhanced functional pathway annotations for differentially expressed gene based direct reprogramming and differentiation clusters 14.30-14.50 Alexey Sizykh, Khalimat Murtazalieva, Yulia Vyshkvorkina, Tao-Chuan Shih, Tun-Wen Pai Alexey Stupnikov, Yulia Medvedeva National Taipei University of Technology, Taipei, Taiwan Moscow Institute of Physics and Technology, Moscow, Russia ecCEBPA in regulation of CpG methylation in acute myeloid leukemia Adewale Ogunleye, Romanova Ekaterina, Yulia Medvedeva 14.50-15.10 Discussion Moscow Institute of Physics and Technology, Dolgoprudny, Russia Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Science, Moscow, Russia 15.10-15.30 Break Hall Pirogov 15.30-16.30 Plenary Session Chair: Yuri Porozov, Sechenov University, Moscow, Russia Keynote Talk 3 15.30-16.30 Protein archeology: How proteins emerged and evolve? Nir Ben-Tal, Department of Biochemistry & Molecular Biology, Tel Aviv University, Israel PROGRAM 16 International Symposium on Bioinformatics Research and Applications (ISBRA) 1-4 December 2020, Moscow

Thursday, December 3rd, 2020 8.00-09.00 Joining the online conference. Introduction to the technical information (for online participants) Hall Pirogov Abrikosov Parallel Sessions 9.00-10.20 Session 5A: Session 5B: Drug Targets Cancer Classification Maria Poptsova, Chairs: Big Data and Information Retrieval School TBA Higher School of Economics, Moscow, Russia SPOC: Identification of drug targets in biological networks via set Signet ring cell detection with classification reinforcement detection network preference output control Sai Wang, Caiyan Jia, Zhineng Chen, Xieping Gao Hao Gao, Min Li, Fang-Xiang Wu 9.00-9.20 Beijing Jiaotong University, Beijing, China School of Computer Science and Engineering, Central South University, Institute of Automation, Chinese Academy of Sciences, Beijing, China Changsha, China School of Medical Imaging and Examination, Xiangnan University, Chenzhou, China University of Saskatchewan, Saskatoon, Canada WDL-DTI: A new drug–target interactions prediction model based on Cancer breakpoint hotspots versus individual breakpoints prediction by machine learning models Wide and Deep Learning Kseniia Cheloshkina, Islam Bzhikhatlov, Maria Poptsova 9.20-9.40 Yupeng Li, Song He, Zhongnan Zhang, Xiaochen Bo National Research University Higher School of Economics, Moscow, Russia Xiamen University, Xiamen, China ITMO University, Saint Petersburg, Russia Beijing Institute of Radiation Medicine, Beijing, China De novo prediction of drug-target interaction via Laplacian regularized Schatten-p norm minimization Predicting degree of tumor differentiation in lung adenocarcinoma using Deep Learning 9.40-10.00 Gaoyan Wu, Yang Mengyun, Li Yaohang, Jianxin Wang Haolun Yi, Jianhong Cheng, Meilin Jiang, Jin Liu, Lin Wu Central South University, Changsha, Hunan, China Central South University, Changsha, Hunan, China Old Dominion University, Norfolk, United States Transformer neural network for protein specific de novo drug generation Ensemble of SVM for colorectal cancer classification from microarray gene expression data as machine translation problem 10.00-10.20 A.K.M. Kamrul Islam, Saeid Belkasim Daria Grechishnikova Georgia State University, Atlanta, United States Lomonosov Moscow State University, Moscow, Russia 10.20-10.40 Break Hall Pirogov Abrikosov Parallel Sessions

10.40-12.40 Session 6A: Session 6B: 3D Structure Disease Prediction

Chairs: Yuri Porozov, Sechenov University, Moscow, Russia TBA Dilated-DenseNet For Macromolecule Classification In Cryo-electron Tomography Shan Gao, Renmin Han, Xiangrui Zeng, Min Xu and Fa Zhang A risk factor attention-based model for cardiovascular disease prediction 10.40-11.00 Institute of Computing Technology, Chinese Academy of Sciences, Zhichang Zhang, Yanlong Qiu, Xiaohui Qin, Yuanzhe Liu Beijing,China Northwest Normal University, Lanzhou, China Shandong University, Shandong, China Carnegie Mellon University, Pittsburgh, United States

Structural insights into BAK activation at the MOM mediated by tBID and Improving dengue fever prediction by incorporating novel air qualify indexes with random METAXIN-1 during TNF-α-triggered apoptosis forests Daniil Mnevets, Hanna Dudko, Viktar Urban, Alexander Davidovskii, 11.00-11.20 Chao-Yang Kuo, Wei-Wen Yang, Emily Chia-Yu Su Valery Veresov Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei University of Barselona, Barcelona, Spain Medical University, Taipei, Taiwan Institute of Biophysics and Cell Engineering of NAS of Belarus, Minsk, Belarus

The cross-interpretation of QSAR toxicological models Oleg Tinkov, Pavel Polishchuk, Veniamin Grigorev, Yuri Porozov Military Institute, Kishinev, Moldova Diagnosis of ASD from rs-fMRIs based on brain dynamic networks 11.20-11.40 Palacký University and University Hospital in Olomouc, Olomouc, Czech Hongyu Guo, Wutao Yin, Sakib Mostafa, Fang-Xiang Wu Republic; Institute of Physiologically Active Compounds, Russian Academy of University of Saskatcewan, Saskatoon, Canada Sciences, Moscow, Russia; Sechenov University, Moscow, Russia, ITMO University, Saint Petersburg, Russia Deep Learning approach with rotate-shift invariant input to predict RUNX1 and CEBPA mutations in acute myeloid leukemia patients affect DNA methylation and protein homodimer structure expression of regulated genes 11.40-12.00 Anna Hadarovich, Alexander Kalinouski, Alexander Tuzikov Romanova Ekaterina, Zubritskiy Anatolii, Medvedeva Yulia United Institute of Informatics Problems, National Academy of Sciences, Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences Minsk, Belarus Study of pregnane X receptor ligand-binding pocket modulation using Automated Detection of Sleep Apnea from Abdominal Respiratory Signal using Hilbert-Huang molecular dynamics simulations Transform 12.00-12.20 Karina Pats, Ferdinand Molnár Xingfeng Lv, Jinbao Li ITMO University, Saint Petersburg, Russia Heilongjiang University, Harbin, China Nazarbayev University, Nur-Sultan, Kazakhstan A protocol of biopsy sample handling that enables machine learning application to rapid determination of tumor cell percentage using mass spectrometry Stanislav I. Pekov, Denis S. Bormotov, Evgeny S. Zhvansky, Konstantin V. Bocharov, Pavel V. Nikitin, Anatoly A. Sorokin, Vsevolod A. Shurkhay, Vasiliy A. Eliferov, Denis S. Zavorotnyuk, Atom tracking using cayley graphs Alexander A. Potapov, Igor A. Popov Marc Hellmuth, Daniel Merkle, Nikolai Nøjgaard 12.20-12.40 Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia University of Greifswald, Greifswald, Germany N.N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia University of Southern Denmark, Odense, Denmark Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, Russia V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia

12.40-13.10 Break Hall Pirogov Abrikosov Parallel Sessions 13.10-14.50 Session 7A: Session 7B: Evolution Disease Association Anna Gambin, Institute of Informatics, University of Warsaw, Chairs: Warsaw, Poland TBA IndelsRNAmute: Predicting deleterious multiple point substitutions and Identification of a novel compound heterozygous variant in NBAS causing bone fragility by the indels mutations type of osteogenesis imperfecta Alexander Churkin, Yann Ponty, Danny Barash Diana Petukhova, Elizaveta Gurinova, Aitalina Sukhomyasova, Nadezhda Maksimova 13.10-13.30 Sami Shamoon College of Engineering, Beersheba, Israel North Eastern Federal University in Yakutsk, Yakutsk, Russia Ecole Polytechnique, Palaiseau, France Republican Hospital №1 – "National Medical Center", Yakutsk, Russia Ben Gurion University, Beersheba, Israel M. K. Ammosov North-Eastern Federal University, Yakutsk, Russia Functional evolutionary modeling exposes overlooked protein-coding Isoform-disease association prediction by data fusion genes Qiuyue Huang, Jun Wang, Xiangliang Zhang, Guoxian Yu 13.30-13.50 involved in cancer Southwest University, Chongqing, China Nadav Brandes, Nathan Linial, Michal Linial King Abudullah University of Science and Technology, Thuwal, Saudi Arabia Hebrew University of Jerusalem, Jerusalem, Israel Revised time estimation of the ancestral chromosomal fusion EpIntMC: Detecting Epistatic Interactions using Multiple Clusterings Barbara Poszewiecka, Krzysztof Gogolewski, Paweł Stankiewicz, Anna Huiling Zhang, Guoxian Yu, Wei Ren, Maozu Guo, Jun Wang 13.50-14.10 Gambin Southwest University, Chongqing, China Institute of Informatics, University of Warsaw, Warsaw, Poland Beijing University of Civil Engineering and Architecture, Beijing, China Baylor College of Medicine, Houston, United States Evolution of transcriptional regulation of histidine metabolism in gram-positive bacteria German Ashniev, Natalia Sernova, Alexey Shevkoplias, Ivan Rodionov, Irina Rodionova, Aleksandr Arzamasov, Alexey Vitreschak, Predicting Parkinson disease genes based on brain-specific functional gene networks Mikhail Gelfand, Dmitry Rodionov 14.10-14.30 Yunsheng Wang, Yingyi Liu, Cuixiang Lin, Weisheng Liu, Hongdong Li Institute for Information Transmission Problems of the Russian Academy of Central South University, Changsha, China Sciences (Kharkevich Institute), Moscow, Russia University of California, San Diego, United States Sanford-Burnham-Prebys Medical Discovery Institute, San Diego, United States miRNA-disease associations prediction based on negative sample selection and multi-layer Mitochondrial fostering: the mitochondrial genome may play a role in perceptron plant orphan gene evolution 14.30-14.50 Na Li, Guihua Duan, Cheng Yan, Fangxiang Wu, Jianxin Wang Seth O'Conner, Ling Li Central South University, Changsha, China Mississippi State University, Starkville, United States University of Saskatchewan, Saskatoon, Canada 14.50-15.00 Break Hall Pirogov 15.00-16.00 Plenary Session Chair: Ion Mandoiu, University of Connecticut, Storrs, USA Keynote Talk 4 15.00-16.00 Tumor phylogenetics in the era of single cell sequencing Cenk Sahinalp, Cancer Data Science Lab, National Cancer Institute, NIH, Maryland, USA PROGRAM 16 International Symposium on Bioinformatics Research and Applications (ISBRA) 1-4 December 2020, Moscow

Friday, December 4th, 2020 8.30-9.30 Joining the online conference. Introduction to the technical information (for online participants) Hall Pirogov Session 8A: 9.30-11.10 Single-Cell

Chair: Ion Mandoiu, University of Connecticut, Storrs, USA Resolving tumor heterogeneity from single-cell transcriptome by deep embedded clustering Yanglan Gan, Yongchang Xin, Wenjing Guo, Guobing Zou 9.30-9.50 Donghua University, Shanghai, China Shanghai University, Shanghai, China A new and effective two-step clustering approach for single cell RNA sequencing data 9.50-10.10 Rui-Yi Li, Jihong Guan, Zhiye Wang, Shuigeng Zhou Tongji University, Shanghai, China A gene selection approach for enhancing clustering performance of single-cell RNA-seq data Xiaoshu Zhu, Jian Li, Xiaojun Ding, Lin Li, Xiaoqing Peng, Hongdong Li 10.10-10.30 Central South University, Changsha, China Yulin Normal University, Yulin, China

Integer linear programming formulation for the Unified Duplication-Loss-Coalescence Model Javad Ansarifar, Alexey Markin, Pawel Gorecki, Oliver Eulenstein 10.30-10.50 Iowa State University, Ames, United States University of Warsaw, Warsaw, Poland

Phylogeny and possible functions of bacterial and protozoal lipoxygenases Georgy Kurakin, Anna Samoukina, Nadezhda Potapova 10.50-11.10 Tver State Medical University, Tver, Russia Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow, Russia

11.10-11.30 Break Hall Pirogov 11.30-12.30 Plenary Session

Chair: Yuri Porozov, Sechenov University, Moscow, Russia Anton Buzdin, Sechenov University, Moscow, Russia Keynote Talk 5 Bioinformatics as an important tool for new developments: creation of a new model for the formation of amyloid, actin filaments and new antibacterial 11.30-12.30 peptides Oxana V. Galzitskaya, Institute of Protein Research, Russian Academy of Sciences, Pushchino, Russia Hall Pirogov Abrikosov Parallel Sessions 12.30-14.50 Session 9A: Session 9B: Systems & Sequence Analysis Network Analysis Alexander Tuzikov, United Institute of Informatics Problems, National Min Zeng, School of Computer Science and Engineering, Central South Chairs: Academy of Sciences of Belarus University, Changsha, China Knowledge enhanced distant supervision for medical relation Ess-NEXG: Predict essential proteins by constructing a weighted protein extraction from Chinese EMRs interaction network based on node embedding and XGBoost 12.30-12.50 Qing Zhao, Jianqiang Li, Xu, Wang, Zu, Ju Nian Wang, Min Zeng, Jiashuai Zhang, Yiming Li, Min Li Beijing University of Technology, Beijing, China School of Computer Science and Engineering, Central South University, Changsha, Xinjiang University of Finance and Economics, Urumchi, China China Protein structural domain-disease association prediction based on Visualizing the knowledge structure and evolution of bioinformatics heterogeneous networks 12.50-13.10 Jiaqi Wang, Zeyu Li, Jiawan Zhang Lei Deng, Lianping Deng, Jingpu Zhang College of Intelligence and Computing, Tianjin University, Tianjin, China Central South University, Changsha, China Henan University of Urban Construction, Pingdingshan, China Search for tandem repeats in the first chromosome from the rice Identifying essential proteins from protein-protein interaction networks based on genome influence maximization Eugene Korotkov, Anastasiya Kamonskaya, Mariya Korotkova Weixia Xu, Yunfeng Dong, Jihong Guan, Shuigeng Zhou 13.10-13.30 Institute of Bioengineering, Research Center of Biotechnology of the Russian Shanghai Lixin University of Accounting and Finance, Shanghai, China Academy of Sciences, Moscow, Russia Fudan University, Shanghai, China National Research Nuclear University MEPhI (Moscow Engineering Physics Tongji University, Shanghai, China Institute), Moscow, Russia How to accurately predict RNA:DNA triple helices genome-wide Elena Matveishina, Ivan Antonov, Yulia Medvedeva A New Network-based Tool to Analyse Competing Endogenous RNAs 13.30-13.50 Lomonosov Moscow State University, Moscow, Russia Selcen Ari Yuka, Alper Yilmaz Institute of Bioengineering, Research Center of Biotechnology, Russian Yildiz Technical University, Istanbul, Turkey Academy of Science, Moscow, Russia Identification of essential genes with NemoProfile and various machine learning Study of rice SINE repeats with a new correlation-based method models 13.50-14.10 Yulia Suvorova, Eugene Korotkov Yangxiao Wang, Wooyoung Kim Research Centre of Biotechnology RAS, Moscow, Russia University of Washington Bothell, Bothell, United States

HiChew: a tool for TAD clustering in embryogenesis Nikolai S.Bykov1, Olga M. Sigalova4, Mikhail S. Gelfand1,2, Aleksandra A. Galitsyna1,2,3

NemoLib: Network Motif Libraries for network motif detection and analysis 14.10-14.30 Skolkovo Institute of Science and Technology, Moscow, Russia Wooyoung Kim, Zachary Arthur Brader A.A.Kharkevich Institute for Information Transmission Problems, Moscow, University of Washington, Bothell, United States Russia Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia Genome Biology Unit, EMBL, Heidelberg, Germany Quantitative analysis of the dynamics of maternal gradients in the early Drosophila embryo Alexander Spirov, Ekaterina M. Myasnikova, Victoria Yu. Samuta NemoCluster: Graph Clustering Algorithm Utilizing Higher Order Network Motifs SUNY at Stony Brook, New York, United States 14.30-14.50 Nicola Rohde, Wooyoung Kim Peter the Great St.Petersburg Polytechnic University, Saint Petersburg, University of Washington, Bothell, United States Russia Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, Saint Petersburg, Russia 14.50-15.00 Break Hall Pirogov 15.00-15.30 Closing Ceremony