University of Groningen

Intestinal nuclear receptor signaling in cystic fibrosis Doktorova, Marcela

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record

Publication date: 2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA): Doktorova, M. (2017). Intestinal nuclear receptor signaling in cystic fibrosis. University of Groningen.

Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment.

Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

Download date: 06-10-2021 Intestinal nuclear receptor signaling in cystic fibrosis

Marcela Doktorova Demmin Cover design: Ridderprint B.V., Ridderkerk, The Netherlands Layout: Ridderprint B.V., Ridderkerk, The Netherlands Printed by Ridderprint B.V., Ridderkerk, The Netherlands

ISBN: 978-94-6299-689-2

© 2017 Marcela Doktorova Demmin. All rights reserved. No parts of this thesis may be reproduced, stored or transmitted, in any form or by any means, without permission of the author.

,Intestinal nuclear receptor signaling in cystic fi brosis,,

PhD thesis

,to obtain the degree of PhD at the UniversityIntestinal of Groningen nuclear receptor signaling in on the authority of the Rector Magnifi cus Prof. E. Sterkencystic fibrosis and in accordance with the decision by the College of Deans.

This thesis will be defended in public on

Wednesday 1 November 2017 at 11.00 hours PhD thesis by

to obtain the degree of PhD at the University of Groningen Marcela Demmin on the authority of the Rector Magnificus Prof. E. Sterken born on 11 September 1988 and in accordance with in Bratislava, Slovakia the decision by the College of Deans.

This thesis will be defended in public on

Wednesday 1 November 2017 at 11.00 hours

by

Marcela Demmin

born on 11 September 1988 in Bratislava, Slovakia

Supervisors Prof. H.J. Verkade Prof. J.W. Jonker

Assessment Committee Prof. F. Kuipers Prof. G.H. Koppelman Prof. R.H.J. Houwen

Paranymphs Marleen Schonewille Ivo Pieter van de Peppel

The research described in this thesis was conducted at the Department of Pediatrics, Section Molecular Metabolism and Nutrition, University Medical Center Groningen, The Netherlands. This project was funded by the Dutch Cystic Fibrosis Foundation (Nederlandse Cystic Fibrosis Stichting) and by the Jan Kornelis de Cock Stichting.

The printing of this dissertation was financially supported by:

The University of Groningen

The University Medical Center Groningen the Groningen University Institute for Drug Exploration (GUIDE) Table of contents

Chapter 1 General introduction and scope of the thesis 7

Chapter 2 Intestinal PPARδ protects against diet-induced obesity, insulin 27 resistance and dyslipidemia

Chapter 3 Impaired intestinal farnesoid X receptor signaling in cystic fibro- 51 sis mice

Chapter 4 CFTR potentiator ivacaftor restores FGF19 regulated bile acid 93 homeostasis in cy