Author Manuscript Published OnlineFirst on April 21, 2014; DOI: 10.1158/0008-5472.CAN-13-3220 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors Jennifer M Mason1,2, Hillary L. Logan1,2, Brian Budke1, Megan Wu1, Michal Pawlowski3, Ralph R. Weichselbaum1,4, Alan P. Kozikowski3, Douglas K. Bishop1,5,6, and Philip P. Connell1,6 1Department of Radiation and Cellular Oncology, 4Ludwig Center for Metastasis Research, 5Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 3Department of Medicinal Chemistry and Pharmacognosy, Drug Discovery Program, University of Illinois at Chicago, Chicago, IL 2These authors contributed equally 6These authors contributed equally Precis: We developed a novel therapeutic strategy that exploits the high levels of RAD51 overexpression that occur in human cancers, using the RAD51-stimulatory compound RS-1 to form genotoxic RAD51 protein complexes on undamaged chromatin. Key Words: DNA repair, Homologous recombination, RAD51, RS-1 Conflicts of interest: The authors disclose no potential conflicts of interest Running Title: RAD51-stimulatory compound kills malignant cells Correspondence should be directed to: Philip P. Connell MD Dep. of Radiation and Cellular Oncology University of Chicago 5758 S. Maryland Ave, MC 9006 Chicago, IL 60637 Phone: (773) 834-8119 Fax: (773) 702-0610 email:
[email protected] 1 Downloaded from cancerres.aacrjournals.org on October 2, 2021. © 2014 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 21, 2014; DOI: 10.1158/0008-5472.CAN-13-3220 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.