Rabbit Anti-Human ITGAX monoclonal antibody, clone TJ20-17 (DCABH-2620) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Target CD11c

Immunogen Recombinant

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Clone TJ20-17

Purification Protein A purified.

Conjugate Unconjugated

Applications WB, IHC, IP

Molecular Weight 128 kDa(Predicted)

Cellular Localization Membrane.

Positive Control Human spleen tissue, human tonsil tissue.

Format Liquid

Size 100 μl

Buffer 1×TBS (pH7.4), 1% BSA, 40% Glycerol.

Preservative 0.05% Sodium Azide

Storage Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Warnings For research use only

BACKGROUND

Introduction Integrin αX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with β2 chain to form a leukocyte-specific integrin known as

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved inactivated- (iC3b) receptor 4 (CR4). Integrin αX/β2 shares similar properties of the αM/β2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin αX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. and DNA elements that influence transcription of Integrin αX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin αX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

Keywords 95 alpha chain;95;CD 11c;CD11 antigen-like family member C;CD11c;CD11c antigen; receptor 4 subunit;CR4;;Integrin alpha X chain;Integrin alpha-X;Integrin aX;Integrin subunit alpha X;integrin, alpha X (antigen CD11C (p150), alpha polypeptide);integrin, alpha X (complement component 3 receptor 4 subunit;ITAX_HUMAN;ITGAX;LEU M5 alpha subunit;Leu M5;Leukocyte adhesion glycoprotein p150 95 alpha chain;Leukocyte adhesion glycoprotein p150;Leukocyte adhesion receptor p150 95;Leukocyte adhesion receptor p150;Leukocyte surface antigen p150 95 alpha subunit;Leukocyte surface antigen p150 alpha subunit;Myeloid membrane antigen alpha subunit;p150 95 integrin alpha chain;p150;p150/95;SLEB6 antibody

GENE INFORMATION

Entrez ID 3687

UniProt ID P20702

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved