1 New drugs in canine reproduction nAglipristone (ALIZIN®) nDeslorelin (SUPRELORIN®) n (YPOZANE®) Aglipristone Alizin® Misalliance in Bitches n2 injections 24hrs apart n10mg/kg/injection nDays 0 to 45 nPrior to day 22 = ~100% efficacy nAfter day 22 = 95% efficacy nMUST have accurate weight for correct dose Misalliance in Bitches nAglipristone blocks the receptors for several days nDoes not have any other effect nVery safe nInjection itself is unpleasant especially in breeds like Greyhounds

5 5 Misalliance in Bitches nHas to be injected at the end of season: nsperm can outlive nif progesterone hasn’t risen yet it does not work nMatings after treatment could still result in a pregnancy

6 6 Other uses (off label) nMisalliance in Queens Only about 85% success rate

n15mg/kg – 2 injections 24hrs apart nThe earlier after mating the better Other uses (off label) nNon surgical treatment of Pyometra Younger animals -Should only be considered in females still intended for breeding. Should be bred at the next season (about 50% pregnancy rate) otherwise there is a high incidence of re-occurrence -Have to be well enough to undergo several days of treatment Other uses (off label) nNon surgical treatment of Pyometra Older animals - Opening cervix in closed pyometra cases - pre-operative treatment if animal is not well enough for surgery - Pre-operative if animal is booked in for the next day to reduce volume in uterus Other uses (off label) nNon surgical treatment of Pyometra

nBitches – 10mg/kg on days 1,2 &7 or 1, 2 & 8

nQueens – 15mg/kg on days 1,2 &7 or 1, 2 &8

Additional Antibiotic treatment for 4-6 weeks Other uses (off label) nInduction of Parturition -Should only be used when ovulation monitoring has taken place, otherwise non-viable premature puppies may be born -Parturition can be brought forward in unwell females (large litters, , heart conditions)

nDay 58 on 2 injections 15mg/kg 9hrs apart Other uses (off label) nFeline Mammary Fibroadenomatous Hyperplasia

n10mg/kg for 2 days weekly for 1-4 weeks Disadvantages of Aglipristone nExpensive especially in larger breeds nOily suspension that can sometimes irritate injection sites Deslorelin SUPRELORIN® Deslorelin (SUPRELORIN®) nGnRH superagonist nSlow release implant that lasts 6 months nNaturally resorbed over time nSame implant for all sizes of dogs Deslorelin (SUPRELORIN®) Before and During and After Deslorelin (SUPRELORIN®)

Advantages nNon surgical contraceptive nReversible down regulation of male fertility nDogs can be implanted every 6 months to extend use nMajority of dogs will return to normal sperm parameters within 12 months of treatment Deslorelin (SUPRELORIN®)

Disadvantages nDisuse atrophy of testicles (show dogs) nTransient increase of in the first 2 weeks after implantation nLength of implants activity varies between individuals and can’t be changed once administered Off Label use of Deslorelin nAnal adenomas

nWill mimic castration’s effect

nHighlights other hormonal influences nGrowth Off Label use of Deslorelin nFerrets

nAlternative to castration nTreatment of hyperandrogenism nUsed in females to prevent hyperoestrogenism Ypozane® Benign Prostatic Hyperplasia (BPH) nDogs are the only species with man to develop spontaneous disease of the later in life nOften under diagnosed until later in problems become more serious nBPH is very common in dogs (>50% entire males over 5y) as a result of long term exposure to testosterone nBPH can predispose for prostatitis and other prostatic diseases Ca