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Edition 1/2013 Manufacturer of key Small Molecules New Biochemicals, Rare Natural Products & Antibiotics

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Antidiabetic Compound Mitochondrial Complex II Inhibitor

Salsalate Atpenin A5 AG-CR1-3574-G001 1 g AG-CN2-0100-C250 250 µg

AG-CR1-3574-G005 OH O 5 g AG-CN2-0100-M001 1 mg OH O Cl Formula: C14 H10 O5 O O Formula: C15 H21 Cl 2NO 5 H3CO Cl MW: 258.2 OH MW: 366.2 CH 3 CH 3 CAS: 552.94.3 CAS: 119509-24-9 H3CO N OH

Potent Low Toxicity Shh Agonist Stimulator of Antibiotic Production SAG Analog (Low Tox) Hormaomycin AG-CR1-3517-M001 1 mg BVT-0107-C500 500 µg BVT-0107-M001 O2N 1 mg Formula: C28 H27 Cl 2N3OS CH 3O H3C N H O MW: 524.5 Formula: C 55 H69 N10 O14 Cl (r)(r) NH HN H N MW: 1129.7 O (r)(r) CAS: H3C NH HN CH 3 S N 121548-21-8

H3C O O N O H3C O Cl Cl O O NO 2 HN LIT: Potent small molecule Hedgehog agonists induce VEGF expression in vitro: BVT: Manufactured by BioViotica CH 3 K. Seifert, et al.; Bioorg. Med. Chem. (Epub ahead of print) (2012) HN

O N Cl HO

Visit our website www.adipogen.com for a comprehensive overview on Small Molecules! Stem Cell Biology Modulators

BIX 01294 (free base) (Stem cell inducer) Y-27632 . 2HCl AG-CR1-0051 1 mg | 5 mg | 25 mg AG-CR1-3564-M001 1 mg AG-CR1-3564-M005 5 mg NU6102 (Potent CDK1/CDK2 inhibitor/ AG-CR1-3564-M025 25 mg ROCK-II inhibitor) AG-CR1-0020 1 mg | 5 mg Formula: C14 H21 N3O . 2HCl MW: N NH +Cl - + - 247.3 . 73.0 2 NH 3 Cl Pifithrin- D . HBr (p53 inhibitor) CAS: 146986-50-7 AG-CR1-0004 5 mg | 10 mg | 25 mg O CH 3 Shz-1 (Enhancer of regenerative repair) Enhances the survival and cloning efficiency of dissociated human embryonic stem (hES) cells without affecting their AG-CR1-3502 1 mg | 5 mg pluripotency. Increases survival rate of hES cells undergoing cryopreservation. ROCK inhibitor. Prevents apoptosis. For more Compounds see www.adipogen.com!

Sonic Hedgehog Modulators

Cyclopamine (Cell permeable Smo inhibitor) GANT61 AG-CN2-0028 1 mg | 5 mg AG-CR1-3561-M001 1 mg Resveratrol (Gli1 mRNA expression inhibitor) AG-CR1-3561-M005 N 5 mg AG-CN2-0033 50 mg | 100 mg | 500 mg H3C CH 3 H3C CH 3 Formula: : C 27 H35 N5 N N MW: 429.6 Robotnikinin (Shh signaling modulator) N N CAS: 500579-04-4 AG-CR1-0069 1 mg SAG (Cell permeable Smo agonist) Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced AG-CR1-3506 1 mg | 5 mg transcription. Hedgehog (Hh) signaling pathway inhibitor, downstream of Smo and SUFU. SAG Analog (high activity) AG-CR1-3518 1 mg

Curcumin (high purity) (Downregulates Shh & Gli1) SANT-2 (Cell permeable Smo antagonist) AG-CN2-0059 10 mg | 50 mg | 250 mg AG-CR1-3514 1 mg | 5 mg

Potent Serine Threonine Protein Phosphatase Inhibitors

Okadaic acids – New from AdipoGen! Okadaic acid (high purity)

AG-CN2-0056-C025 25 µg Okadaic acid . NH 4 (high purity) AG-CN2-0056-C100 100 µg AG-CN2-0058 25 µg | 100 µg | 1 mg AG-CN2-0056-M001 1 mg

Formula: C44 H68 O13 Okadaic acid . K (high purity) MW: 805.0 AG-CN2-0060 25 µg | 100 µg | 1 mg CAS: 78111-17-8

CH 3 Okadaic acid . Na (high purity) O OH H H AG-CN2-0062 25 µg | 100 µg | 1 mg O H O H3C HO H C OH O O H O 3 H Fostriecin OH CH 3 O O OH CH 3 AG-CN2-0057 10 µg

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BAY 43-9006 (Raf kinase inhibitor) SMI-4a AG-CR1-0025 1 mg | 5 mg | 25 mg AG-CR1-3503-M005 5 mg O 6BIO (Potent GSK-3 D/E inhibitor) Formula: C H F NO S CF 3 11 6 3 2 AG-CR1-0056 1 mg | 5 mg | 25 mg MW: 273.2 HN S CAS: 327033-36-3 Cercosporin (Potent PKC inhibitor) O AG-CN2-0111 1 mg | 5 mg Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of p27Kip1. Inhibitor of the mammalian target of rapamycin C1 (R)-CR8 (Potent GSK-3 D/E inhibitor) (mTORC1) pathway. Inhibitor of PRAS40 phosphorylation and AG-CR1-0039 1 mg | 5 mg mTOR activity. (S)-CR8 (Potent GSK-3 D/E inhibitor) AG-CR1-0040 1 mg | 5 mg Debromohymenialdisine (PKC & MEK-1 inhibitor) Bisindolylmalei