Case Report
Open Access Journal of Case Report Biomedical Science ISSN: 2690-487X
Histopathological Findings in an Autopsy of Covid-19 Positive Young Male
Sonia Chhabra1, Niti Dalal2*, Renuka Verma3, Jyoti Dahiya4 and Sunita Singh5 1Professor, Department of Pathology, PGIMS, India 2Senior Resident, Department of Pathology, PGIMS, India 3Associate Professor, Department of Pathology, PGIMS, India 4Junior Resident, Department of Pathology, PGIMS, India 5Senior Professor & Head, Department of Pathology, PGIMS, India
ABSTRACT
th First confirmed case of novel coronavirus was identified in December 2019 in Wuhan, China and designated as SARS coronavirus-2 (SARS-CoV-2). Afterwards, it spreads very rapidly all over the world. World Health Organization declared it as pandemic on 11 march, 2020. The symptoms range from mild to severe acute respiratory distress syndrome leading to hospitalization and eventually, death of the patient. Lung is the predominant organ which is severely affected. Here, we present an autopsy finding in heart and KEYWORDS:lungs in a 22-year-old male who died with clinical diagnosis of pneumonia and ARDS in November 2020.
ABBREVIATIONS: COVID 19; Autopsy; Heart; Lungs
SARS-CoV-2: Severe Acute Respiratory Syndrome Coronavirus 2; MERS: Middle East Respiratory Syndrome; SARS: Severe Acute Respiratory Syndrome; ACE2: Angiotensin- Converting Enzyme 2; ARDS: Acute Respiratory Distress Syndrome
INTRODUCTION gain entry into cells via
the angiotensin- converting Ever since it was first reported in China, all the countries around enzyme 2 (ACE2), which is expressed in multiple tissue types the world have faced outbreaks of COVID-19 and is a major cause including endothelium. The virus disproportionately affects the of mortality worldwide. Italy was the first country to report a huge respiratory system and in elderly patients with comorbidities such number of COVID-19 cases [1]. as hypertension, diabetes, obesity, and cardiovascular disease. In COVID-19 is caused by the severe acute respiratory syndrome respiratory system, it leads to diffuse alveolar damage, edema and coronavirus 2 (SARS-CoV-2) and is the seventh member of a marked increase in lung weights at autopsy [2,3]. the coronavirus family [1]. Coronaviruses are single-stranded, SARS-CoV-2 infection also releases the significant amount of enveloped RNA viruses that cause respiratory illnesses among pro-inflammatory cytokines that aggravate interstitial pneumonia humans and animals. and acute respiratory distress syndrome (ARDS). This results into viral sepsis with prominent hypercoagulability and multiorgan Disease cause by these viruses range from the common cold to severe acute respiratory syndrome (SARS) and dysfunction [3]. Middle East respiratory syndrome (MERS) [2].Coronaviruses Quick Response Code: Address for correspondence: Niti Dalal, Senior Resident, Department of Pathology, PGIMS, India Received: July 19, 2021 Published: August 13, 2021
How to cite this article: Sonia C, Niti D, Renuka V, Jyoti D, Sunita S. Histopathological Findings in an Autopsy of Covid-19 Positive Young Male. 2021- 4(4) OAJBS.ID.000315. DOI: 10.38125/ OAJBS.000315
C 2021 Open Access Journal of Biomedical Science 1122 Open Acc J Bio Sci. August- 4(4): 1122-1124 Niti Dalal Case Report
CASE REPORT for histopathological examination, keeping in view the biosafety measures. Specimen was received in the Department of Pathology in A 22-year-old prisoner male presented with high grade fever 10% formalin. The jar was remained closed for another 10 days and and sore throat. RT-PCR for COVID-19 was found out to be positive. afterwards, grossing was done with proper biosafety precautions. Following which, he was admitted to the hospital. He was given On gross examination, heart weighed 240gm and measured injection piperacillin, tazobactam, remdesivir, methyl