Gene Panel Comparison 732 Shared Genes

HTG EdgeSeq Oncology Biomarker Panel - quantitative detection of 2,559 transcripts HTG EdgeSeq Precision Immuno-Oncology Panel - quantitative detection of 1,392 transcripts

A2M C3 CD14 CHMP4B DUSP4 HELLS IL16 ITGA4 MAGEA4 NFATC1 ABCB11 C3AR1 CD160 CHUK DUSP6 HES1 IL17A ITGA5 MAGEB2 NFATC3 ABCC2 C5 CD163 CKLF EBF4 HES5 IL17F ITGA6 MAGEC1 NFATC4 ABCC6 CALML3 CD19 CLCA2 ECT2 HEY1 IL17RB ITGAM MAGEC2 NFKB1 ABCF1 CARD11 CD2 CLDN3 EEF1G HEY2 IL18 ITGB1 MAP2K1 NFKB2 ABCG2 CASP1 CD209 CMKLR1 EGFR HEYL IL19 ITGB2 MAP2K2 NFKBIA ACKR3 CASP10 CD22 COL1A1 EGR1 HGF IL1A ITGB3 MAP2K4 NGFR ACTR3B CASP3 CD24 COL1A2 EGR3 HIF1A IL1B ITGB4 MAP2K6 NKX2-1 ADAM17 CASP4 CD27 COL3A1 EIF2AK2 HJURP IL1R1 ITGB7 MAP2K7 NLRP3 ADORA2A CASP5 CD274 CREB1 ELK1 HK2 IL1R2 ITLN2 MAP3K1 NOD1 ADORA2B CASP8 CD276 CREB5 EMP1 HLA-A IL1RAP JAK1 MAP3K5 NOD2 AGER CAV1 CD28 CREBBP ENG HLA-B IL1RN JAK2 MAP4K1 NOS2 AHR CCL1 CD33 CRP ENO1 HLA-E IL2 JAK3 MAPK1 NOS3 AICDA CCL11 CD34 CSF1 ENTPD1 HMGB1 IL20 KCNK5 MAPK11 NOTCH1 AKT1 CCL13 CD38 CSF2 EOMES HMGCS2 IL20RA KDM5B MAPK14 NOX1 AKT3 CCL14 CD3D CSF3 EP300 HMOX1 IL20RB KDR MAPK3 NPM1 ALCAM CCL15 CD4 CSF3R EPCAM HNF1A IL21 KIF14 MAPK8 NRP1 ANLN CCL16 CD40 CTLA4 ERBB2 HNF1B IL22 KIF2C MAPKAPK2 NT5E ANPEP CCL17 CD40LG CTNNB1 ERBB3 HPN IL22RA1 KIT MBL2 NTN3 ANXA1 CCL18 CD44 CTSH ETS1 HRAS IL22RA2 KLRB1 MCM2 NTRK2 APAF1 CCL19 CD47 CTSL ETS2 HSP90B1 IL23A KLRD1 MCM6 NUF2 APP CCL2 CD5 CTSS ETV1 HSPA1A IL23R KLRG1 MCM7 NUSAP1 ASPM CCL20 CD52 CX3CL1 ETV4 IBSP IL24 KPNA2 MECOM OAS1 ATF1 CCL21 CD55 CX3CR1 EXO1 ICAM1 IL27 KREMEN1 MEF2C OAZ1 ATF2 CCL22 CD59 CXCL1 EZH2 ICOS IL2RA KRT13 MELK OCLN ATG12 CCL23 CD63 CXCL10 FABP4 ID2 IL2RB KRT16 MERTK OLR1 ATG16L1 CCL24 CD68 CXCL11 FADD ID3 IL2RG KRT17 MGA ORC6 ATG5 CCL25 CD70 CXCL12 FAM83B ID4 IL3 KRT18 MIF OSM ATG7 CCL26 CD74 CXCL13 FANCA IDH1 IL33 KRT19 MKI67 PAX5 ATM CCL27 CD79A CXCL14 FAS IDH2 IL3RA KRT5 MLF1 PBX1 ATP5F1 CCL28 CD80 CXCL16 FASLG IDO1 IL4 KRT6A MME PCNA ATXN1 CCL3 CD83 CXCL2 FCER2 ID02 IL4R KRT7 MMP11 PDCD1 AURKA CCL4 CD86 CXCL3 FEN1 IFI27 IL5 KRT8 MMP2 PDCD1LG2 AURKB CCL5 CD8A CXCL5 FGFR3 IFIT2 IL5RA L1CAM MMP9 PDGFC AXIN1 CCL7 CDC20 CXCL6 FLT1 IFNAR1 IL6 LAG3 MPO PDGFRB AXIN2 CCL8 CDC25A CXCL8 FLT3 IFNB1 IL6R LAMC3 MS4A1 PDK1 AXL CCNA2 CDC25C CXCL9 FLT3LG IFNG IL6ST LAT MSH2 PDK2 BATF CCNB1 CDC6 CXCR1 FMO5 IFNGR1 IL7 LCN2 MSH3 PECAM1 BAX CCNB2 CDC7 CXCR2 FN1 IFNL3 IL7R LGALS1 MSH4 PF4 BCL10 CCND1 CDH1 CXCR3 FOS IGF1R IL9 LGALS3 MSH5 PFKFB3 BCL2 CCND3 CDH15 CXCR4 FOXA1 IGF2R IRAK1 LIF MSH6 PFKFB4 BCL2L1 CCNE1 CDH5 CXCR5 FOXP1 IGFBP3 IRAK2 LIPE MSR1 PGF BCL2L11 CCNE2 CDK1 CXCR6 FOXP3 IHH IRAK3 LOXL1 MST1R PIK3CA BCL6 CCNF CDK4 CYBB FPR1 IKBKB IRF1 LRG1 MT2A PIK3CD BID CCR1 CDK6 CYLD FYN IKBKG IRF2 LTA MTDH PIK3CG BIRC5 CCR10 CDKN1A DAPL1 FZD3 IL10 IRF3 LTB MTOR PKM BMI1 CCR2 CDKN1B DDX5 GATA2 IL10RA IRF4 LTBP1 MUC1 PKMYT1 BMP6 CCR3 CDKN2A DDX58 GATA3 IL10RB IRF5 LTBR MX1 PKP1 BMP7 CCR4 CDKN3 DEFB1 GBP1 IL11 IRF7 LY96 MYBL2 PLAU BRCA1 CCR5 CEACAM5 DEPDC1 GNLY IL11RA IRF8 LYN MYC PLAUR BRCA2 CCR6 CEBPB DIAPH3 GPI IL12A IRF9 LYVE1 MYD88 PLK1 BRIP1 CCR7 CENPF DLGAP5 GTSE1 IL12B IRGM LYZ NCAM1 PLK4 BTK CCR8 CEP55 DNMT1 GZMA IL12RB2 IRS1 MAD2L1 NCL PML BUB1 CCR9 CES1 DPYSL4 GZMB IL13 ISG15 MADCAM1 NDC80 POU5F1 BUB1B CCRL2 CHDH DSG3 GZMH IL13RA2 ITGA2 MAF NEIL3 PPARD C1QA CCT5 CHGA DST HAVCR2 IL15 ITGA3 MAGEA1 NEK2 PPARG

Disclaimer: Sequence of the probe is not necessarily the same on both panels

Gene Panel Comparison HTG EdgeSeq Oncology Biomarker Panel & Precision Immuno-Oncology Panel 1 Gene Panel Comparison 732 Shared Genes

PPBP RELB SMAD7 TAP1 TLR8 TPX2 PPIA RFC4 SMPDL3B TAP2 TLR9 TRAF2 PRAME RIPK2 SNAI1 TBK1 TNF TRAF3 PRC1 RND2 SNAI2 TBX21 TNFAIP3 TRAF6 PRDM1 RNF149 SOCS1 TCF7 TNFRSF10A TRIP13 PRF1 RNF4 SOCS3 TCL1A TNFRSF10B TTK PRKCD RORC SOCS5 TCL1B TNFRSF10C TWIST1 PRKCE RPL38 SOD1 TEK TNFRSF10D TWIST2 PRR15L RPL6 SOX2 TESC TNFRSF11B TXNIP PSMD7 RPS7 SOX9 TFF1 TNFRSF12A TYK2 PSRC1 RRAS2 SPC25 TGFB1 TNFRSF14 TYMS PTEN RRM1 SPI1 TGFB2 TNFRSF17 UBE2C PTGS1 RRM2 SPINK1 TGFBI TNFRSF1B UBE2T PTGS2 RTN1 SPINK5 TGFBR1 TNFRSF21 UBE3A PTPN11 RUNX1 SPOP TGFBR2 TNFRSF25 VCAM1 PTPRC RUNX3 SPP1 THAP11 TNFRSF4 VEGFA PVR S100A8 SSX1 THBS1 TNFRSF8 VEGFC PYCARD S100B STAT1 THY1 TNFRSF9 VSNL1 PYCR1 SELE STAT2 TICAM1 TNFSF10 VTCN1 PYGL SERPINB2 STAT3 TIMP1 TNFSF11 WNT5A RAC1 SERPINB5 STAT4 TIRAP TNFSF13B WNT7B RACGAP1 SERPINE1 STAT5A TK1 TNFSF14 XCL1 RAD51 SKP2 STAT5B TLR1 TNFSF15 XCR1 RAD54L SLAMF7 STAT6 TLR2 TNFSF8 YWHAZ RAG1 SLC11A1 STK32A TLR3 TNFSF9 ZEB1 RB1 SLC25A3 SUSD3 TLR4 TOLLIP RBX1 SLC2A1 SYK TLR5 TOP2A REL SMAD2 TAGLN TLR6 TP53 RELA SMAD3 TAL1 TLR7 TP63 Disclaimer: Sequence of the probe is not necessarily the same on both panels

HTG Molecular Diagnostics, Inc. 3430 E. Global Loop, Tucson, AZ 85706, USA Call 1-877-289-2615 Fax 1-520-547-2837 For Research Use Only. Not for use in diagnostic procedures. [email protected] or [email protected] In the U.S. and other applicable jurisdictions, HTG EdgeSeq is a Service and Support 1-877-507-3259 trademark of HTG Molecular Diagnostics, Inc. Any other trademarks or trade names Orders [email protected] used herein are the intellectual property of their respective owners. Rev 1: 29-JAN-2019

Gene Panel Comparison HTG EdgeSeq Oncology Biomarker Panel & Precision Immuno-Oncology Panel 2