Bipolar Disorder Fact Sheet
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Is Your Depressed Patient Bipolar?
J Am Board Fam Pract: first published as 10.3122/jabfm.18.4.271 on 29 June 2005. Downloaded from EVIDENCE-BASED CLINICAL MEDICINE Is Your Depressed Patient Bipolar? Neil S. Kaye, MD, DFAPA Accurate diagnosis of mood disorders is critical for treatment to be effective. Distinguishing between major depression and bipolar disorders, especially the depressed phase of a bipolar disorder, is essen- tial, because they differ substantially in their genetics, clinical course, outcomes, prognosis, and treat- ment. In current practice, bipolar disorders, especially bipolar II disorder, are underdiagnosed. Misdi- agnosing bipolar disorders deprives patients of timely and potentially lifesaving treatment, particularly considering the development of newer and possibly more effective medications for both depressive fea- tures and the maintenance treatment (prevention of recurrence/relapse). This article focuses specifi- cally on how to recognize the identifying features suggestive of a bipolar disorder in patients who present with depressive symptoms or who have previously been diagnosed with major depression or dysthymia. This task is not especially time-consuming, and the interested primary care or family physi- cian can easily perform this assessment. Tools to assist the physician in daily practice with the evalua- tion and recognition of bipolar disorders and bipolar depression are presented and discussed. (J Am Board Fam Pract 2005;18:271–81.) Studies have demonstrated that a large proportion orders than in major depression, and the psychiat- of patients in primary care settings have both med- ric treatments of the 2 disorders are distinctly dif- ical and psychiatric diagnoses and require dual ferent.3–5 Whereas antidepressants are the treatment.1 It is thus the responsibility of the pri- treatment of choice for major depression, current mary care physician, in many instances, to correctly guidelines recommend that antidepressants not be diagnose mental illnesses and to treat or make ap- used in the absence of mood stabilizers in patients propriate referrals. -
Types of Bipolar Disorder Toms Are Evident
MOOD DISORDERS ASSOCIATION OF BRITISH COLUmbIA T Y P E S O F b i p o l a r d i s o r d e r Bipolar disorder is a class of mood disorders that is marked by dramatic changes in mood, energy and behaviour. The key characteristic is that people with bipolar disorder alternate be- tween episodes of mania (extreme elevated mood) and depression (extreme sadness). These episodes can last from hours to months. The mood distur- bances are severe enough to cause marked impairment in the person’s func- tioning. The experience of mania is not pleasant and can be very frightening to The Diagnotistic Statisti- the person. It can lead to impulsive behaviour that has serious consequences cal Manual (DSM- IV-TR) is a for the person and their family. A depressive episode makes it difficult or -im manual used by doctors to possible for a person to function in their daily life. determine the specific type of bipolar disorder. People with bipolar disorder vary in how often they experience an episode of either mania or depression. Mood changes with bipolar disorder typically occur gradually. For some individuals there may be periods of wellness between the different mood episodes. Some people may also experience multiple episodes within a 12 month period, a week, or even a single day (referred to as “rapid cycling”). The severity of the mood can also range from mild to severe. Establishing the particular type of bipolar disorder can greatly aid in determin- ing the best type of treatment to manage the symptoms. -
Pharmacogenomic Characterization in Bipolar Spectrum Disorders
pharmaceutics Review Pharmacogenomic Characterization in Bipolar Spectrum Disorders Stefano Fortinguerra 1,2 , Vincenzo Sorrenti 1,2,3 , Pietro Giusti 2, Morena Zusso 2 and Alessandro Buriani 1,2,* 1 Maria Paola Belloni Center for Personalized Medicine, Data Medica Group (Synlab Limited), 35131 Padova, Italy; [email protected] (S.F.); [email protected] (V.S.) 2 Department of Pharmaceutical & Pharmacological Sciences, University of Padova, 35131 Padova, Italy; [email protected] (P.G.); [email protected] (M.Z.) 3 Bendessere™ Study Center, Solgar Italia Multinutrient S.p.A., 35131 Padova, Italy * Correspondence: [email protected] Received: 25 November 2019; Accepted: 19 December 2019; Published: 21 December 2019 Abstract: The holistic approach of personalized medicine, merging clinical and molecular characteristics to tailor the diagnostic and therapeutic path to each individual, is steadily spreading in clinical practice. Psychiatric disorders represent one of the most difficult diagnostic challenges, given their frequent mixed nature and intrinsic variability, as in bipolar disorders and depression. Patients misdiagnosed as depressed are often initially prescribed serotonergic antidepressants, a treatment that can exacerbate a previously unrecognized bipolar condition. Thanks to the use of the patient’s genomic profile, it is possible to recognize such risk and at the same time characterize specific genetic assets specifically associated with bipolar spectrum disorder, as well as with the individual response to the various therapeutic options. This provides the basis for molecular diagnosis and the definition of pharmacogenomic profiles, thus guiding therapeutic choices and allowing a safer and more effective use of psychotropic drugs. Here, we report the pharmacogenomics state of the art in bipolar disorders and suggest an algorithm for therapeutic regimen choice. -
Specificity of Psychosis, Mania and Major Depression in A
Molecular Psychiatry (2014) 19, 209–213 & 2014 Macmillan Publishers Limited All rights reserved 1359-4184/14 www.nature.com/mp ORIGINAL ARTICLE Specificity of psychosis, mania and major depression in a contemporary family study CL Vandeleur1, KR Merikangas2, M-PF Strippoli1, E Castelao1 and M Preisig1 There has been increasing attention to the subgroups of mood disorders and their boundaries with other mental disorders, particularly psychoses. The goals of the present paper were (1) to assess the familial aggregation and co-aggregation patterns of the full spectrum of mood disorders (that is, bipolar, schizoaffective (SAF), major depression) based on contemporary diagnostic criteria; and (2) to evaluate the familial specificity of the major subgroups of mood disorders, including psychotic, manic and major depressive episodes (MDEs). The sample included 293 patients with a lifetime diagnosis of SAF disorder, bipolar disorder and major depressive disorder (MDD), 110 orthopedic controls, and 1734 adult first-degree relatives. The diagnostic assignment was based on all available information, including direct diagnostic interviews, family history reports and medical records. Our findings revealed specificity of the familial aggregation of psychosis (odds ratio (OR) ¼ 2.9, confidence interval (CI): 1.1–7.7), mania (OR ¼ 6.4, CI: 2.2–18.7) and MDEs (OR ¼ 2.0, CI: 1.5–2.7) but not hypomania (OR ¼ 1.3, CI: 0.5–3.6). There was no evidence for cross-transmission of mania and MDEs (OR ¼ .7, CI:.5–1.1), psychosis and mania (OR ¼ 1.0, CI:.4–2.7) or psychosis and MDEs (OR ¼ 1.0, CI:.7–1.4). -
Bordering on the Bipolar: a Review of Criteria for ICD-11 and DSM-5 Persistent Mood Disorders Jason Luty
BJPsych Advances (2020), vol. 26, 50–57 doi: 10.1192/bja.2019.54 ARTICLE Bordering on the bipolar: a review of criteria for ICD-11 and DSM-5 persistent mood disorders Jason Luty Jason Luty, MB, ChB, PhD, SUMMARY MRCPsych, is a consultant in addic- Persistent low mood with lack of enjoyment (‘anhe- tions, liaison and general psychiatry The principal manuals for psychiatric diagnosis donia’) is common and often hard to treat in psychi- in south-east England. He trained at have recently been updated (ICD-11 was released atric practice. Recent changes in the two major the Maudsley Hospital, London, and in June 2018 and DSM-5 was published in 2013). spent 8 years as a consultant in diagnostic classification systems – ICD-11 released A common diagnostic quandary is the classification addictions with the South Essex in June 2018 (World Health Organization 2018) Partnership NHS Trust. He has a PhD of people with chronic low mood, especially those in pharmacology, following a study of with repeated self-harm (‘emotionally unstable’ or and DSM-5 (American Psychiatric Association the molecular mechanisms of recep- ‘borderline’ personality disorder). There has been 2013) – make the time apposite to review the diag- tor desensitisation and tolerance, and a great interest in use of type II bipolar affective dis- nostic categories relevant to persistent mood has published in the addictions field. order (‘bipolar II disorder’) as a less pejorative diag- disorders. Correspondence Dr Jason Luty, nostic alternative to ‘personality disorder’,despite fi Consultant Psychiatrist, Athona There is signi cant diagnostic overlap with emo- Recruitment Ltd, 1st Floor, Juniper the radically different treatment options for these tionally unstable/borderline personality disorder, House, Warley Hill Business Park, disorders. -
Chapter 7 Mood Disorders
An Overview of Mood Disorders • Gross Deviations in Mood • 2 Fundamental states: Depression & Mania Chapter 7 • Depression: “The Low” – Major Depressive Episode •The most commonly diagnosed & most severe Mood Disorders depression •Depressed (or in children, irritable) mood state that lasts at least 2 weeks –Cognitive symptoms •Feelings of worthlessness or inappropriate guilt •Diminished ability to concentrate or indecisiveness – Dysthymic Disorder –Disturbed physical functions (vegetative •Similar symptoms to Major Depressive Episode, symptoms) (central to the disorder) but milder •Insomnia or hypersomnia nearly every day –Also fewer symptoms: need only 2 of the •Significant weight loss or gain or change in symptoms, as opposed to 5 in Major Depressive appetite Episode •Fatigue or loss of energy nearly every day •A persistently depressed (or, in children & •Psychomotor agitation or retardation adolescents, irritable) mood that continues for at –Nearly always accompanied by markedly least 2 years diminished interest or ability to experience pleasure –During those 2 years, the individual has never been (anhedonia) from life without the symptoms for more than 2 months at a • Average duration if untreated: 9 months time •Most people with Dysthymia eventually experience a major depressive episode • Mania: “The High” –Abnormally exaggerated elation, joy, or euphoria OR irritability (common toward the –Behavioral symptoms end of the episode) lasting at least 1 week •More talkative / pressured speech –Cognitive symptoms •Psychomotor agitation -
What Is Bipolar Disorder?
Bipolar Disorder Fact Sheet For more information about bipolar or other mental health disorders, call 513-563-HOPE or visit our website at www.lindnercenterofhope.com. What Is Bipolar Disorder? What does your mood Each year, nearly 6 million adults (or approximately 5% of the population) in the U.S. are affected by bipolar disorder, according to the Depression and Bipolar Support say about you? Alliance. While the condition is treatable, unfortunately bipolar disorder is frequently misdiagnosed and may be present an average of 10 years before it is correctly identified. Go to My Mood Monitor™, a three minute assessment Bipolar disorder (also known as bipolar depression or manic depression) is identified for anxiety, depression, PTSD by extreme shifts in mood, energy, and functioning that can be subtle or dramatic. The characteristics can vary greatly among individuals and even throughout the and bipolar disorder, at course of one individual’s life. www.mymoodmonitor.com to see if you may need a Bipolar disorder is usually a life-long condition that begins in adolescence or early professional evaluation. adulthood with recurring episodes of mania (highs) and depression (lows) that can continue for days, months or even years. My Mood Monitor™ Copyright © 2002-2010 by M3 Information™ Phases of Bipolar Disorder • Mania is the activated phase of bipolar disorder and is characterized by extreme moods, increased or impulsive mental and physical activities, and risk taking. • Hypomania describes a mild-to-moderate level of mania. Because it may feel good to the individual experiencing it, this condition can be difficult for someone with bipolar illness to recognize as a concern. -
Life with Bipolar Fact Sheet.Pdf
Being so scared Having so Trying to You do not Exhilarating. You you’remisunderstood paralyzed much energy catch up to want the finally feel like that you stress your own high of the you’re normal, out your mind mind mania to until the anger and your body end; then sets in An amazing after the feeling that high of the leads to feeling Things are mania is horrible going You have no over, the Difficult to tell if great and inhibitions, and lows set in you can trust your it’s scary consequences and reality own perception because don’t apply to becomes a of reality You feel you know what you do problem everything at it will not once and then stay that you are numb way to the world Being on a see-saw Flipping a The of human emotion switch in future your mind “Normal” quickly people are goes Mania is speed. from annoying You must start and Being constantly in bright because finish everything activities that take up to you’ll never Productive, now—you can’t time with hardly any carefree, bleak have that stop moving results or satisfation and then stability exhausting Busy brain, When the mania busy Unending back burns out, you’ve senses, and forth with got nothing left Frightening to be so out of busy libido yourself in you control and off-balance Share what life with bipolar disorder feels like for you in words, images or video by tagging your social media posts with #mentalillnessfeelslike. Posts will be displayed at mentalhealthamerica.net/feelslike where you can also submit anonymously if you choose. -
Which Is It: ADHD, Bipolar Disorder, Or PTSD?
HEALINGHEALINGA PUBLICATION OF THE HCH CLINICIANS’ HANDSHANDS NETWORK Vol. 10, No. 3 I August 2006 Which Is It: ADHD, Bipolar Disorder, or PTSD? Across the spectrum of mental health care, Anxiety Disorders, Attention Deficit Hyperactivity Disorders, and Mood Disorders often appear to overlap, as well as co-occur with substance abuse. Learning to differentiate between ADHD, bipolar disorder, and PTSD is crucial for HCH clinicians as they move toward integrated primary and behavioral health care models to serve homeless clients. The primary focus of this issue is differential diagnosis. Readers interested in more detailed clinical information about etiology, treatment, and other interventions are referred to a number of helpful resources listed on page 6. HOMELESS PEOPLE & BEHAVIORAL HEALTH Close to a symptoms exhibited by clients with ADHD, bipolar disorder, or quarter of the estimated 200,000 people who experience long-term, PTSD that make definitive diagnosis formidable. The second chronic homelessness each year in the U.S. suffer from serious mental causative issue is how clients’ illnesses affect their homelessness. illness and as many as 40 percent have substance use disorders, often Understanding that clinical and research scientists and social workers with other co-occurring health problems. Although the majority of continually try to tease out the impact of living circumstances and people experiencing homelessness are able to access resources comorbidities, we recognize the importance of causal issues but set through their extended family and community allowing them to them aside to concentrate primarily on how to achieve accurate rebound more quickly, those who are chronically homeless have few diagnoses in a challenging care environment. -
Anxiety Disorders
TECHNICAL COMMENTARY Anxiety disorders Introduction excluded from the library. The PRISMA flow diagram is a suggested way of providing Anxiety disorders are a group of mental information about studies included and disorders characterised by excessive fear or excluded with reasons for exclusion. Where no worrying. It is important to recognise comorbid flow diagram has been presented by individual anxiety as it may influence treatment strategies reviews, but identified studies have been and outcomes. described in the text, reviews have been Anxiety disorders include generalised anxiety checked for this item. Note that early reviews disorder, which is characterised by continuous may have been guided by less stringent and excessive worrying for six months or more. reporting checklists than the PRISMA, and that Specific phobias are characterised by anxiety some reviews may have been limited by journal provoked by a feared object/situation, resulting guidelines. in avoidance. Social phobia is anxiety provoked Evidence was graded using the Grading of by social or performance situations. Recommendations Assessment, Development Agoraphobia is anxiety about situations where and Evaluation (GRADE) Working Group escape may be difficult or help might not be approach where high quality evidence such as available. Panic disorder is characterised by a that gained from randomised controlled trials panic attack, which is a distinct episode where (RCTs) may be downgraded to moderate or low a person experiences sudden apprehension if review and study quality is limited, if there is and fearfulness, where they may present with inconsistency in results, indirect comparisons, shortness of breath, palpitations, chest pain or imprecise or sparse data and high probability of choking. -
Children's Mental Health Disorder Fact Sheet for the Classroom
1 Children’s Mental Health Disorder Fact Sheet for the Classroom1 Disorder Symptoms or Behaviors About the Disorder Educational Implications Instructional Strategies and Classroom Accommodations Anxiety Frequent Absences All children feel anxious at times. Many feel stress, for example, when Students are easily frustrated and may Allow students to contract a flexible deadline for Refusal to join in social activities separated from parents; others fear the dark. Some though suffer enough have difficulty completing work. They worrisome assignments. Isolating behavior to interfere with their daily activities. Anxious students may lose friends may suffer from perfectionism and take Have the student check with the teacher or have the teacher Many physical complaints and be left out of social activities. Because they are quiet and compliant, much longer to complete work. Or they check with the student to make sure that assignments have Excessive worry about homework/grades the signs are often missed. They commonly experience academic failure may simply refuse to begin out of fear been written down correctly. Many teachers will choose to Frequent bouts of tears and low self-esteem. that they won’t be able to do anything initial an assignment notebook to indicate that information Fear of new situations right. Their fears of being embarrassed, is correct. Drug or alcohol abuse As many as 1 in 10 young people suffer from an AD. About 50% with humiliated, or failing may result in Consider modifying or adapting the curriculum to better AD also have a second AD or other behavioral disorder (e.g. school avoidance. Getting behind in their suit the student’s learning style-this may lessen his/her depression). -
Mood Disorders
HANDOUT – MOOD DISORDERS How much of the population is affected by mood disorders? Each year, almost 44 million Americans experience a mental disorder. In fact, mental illnesses are among the most common conditions affecting health today. What causes mood disorders / mental illness? Researchers believe most serious mental illnesses are caused by complex imbalances in the brain's chemical activity. They also believe environmental factors can play a part in triggering, or cushioning against, the onset of mental illness. Are mood disorders treatable? Like other diseases, mental illnesses can be treated. The good news is that most people who have mental illnesses, even serious ones, can lead productive lives with proper treatment. Mood disorders are one form of serious mental illness. What are some common mood disorders? Two of the most common mood disorders are depression and bipolar disorder, also known as manic-depressive illness. Bipolar Disorder Description: Extreme mood swings punctuated by periods of generally even-keeled behavior characterize this disorder. Bipolar disorder tends to run in families. This disorder typically begins in the mid-twenties and continues throughout life. Without treatment, people who have bipolar disorder often go through devastating life events such as marital breakups, job loss, substance abuse, and suicide. Symptoms: Mania-expansive or irritable mood, inflated self-esteem, decreased need for sleep; increased energy; racing thoughts; feelings of invulnerability; poor judgment; heightened sex drive; and denial that anything is wrong. Depression-feelings of hopelessness, guilt, worthlessness, or melancholy; fatigue; loss of appetite for food or sex; sleep disturbances, thoughts of death or suicide; and suicide attempts.