Journal of Chemistry
ISSN: 2319-9849 Research and Reviews: Journal of Chemistry Synthesis and Characterization of Benzothiazole and Thiazole Substituted Acetamide Derivatives of Sydnones Himanshu D Patel1, Shahrukh T Asundaria2, Keshav C Patel*2, Kalpesh M Mehta2, Paresh S Patel3, Lina A Patel4 1Department of Chemistry, Silvassa Institute of Higher Learning, Government Aided College of Arts, Commerce and Science, DNHUSS, Silvassa – Naroli – 396235, (U. T. of D & NH) India. 2Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat - 395007 (Gujarat) India. 3Department of Chemistry, Narmada College of Science and Commerce, Zadeshwer, Bharuch - 392011 (Gujarat) India. 4Department of Chemistry, CU Shah Science College, Ashram Road, Ahmedabad – 380014 (Gujarat) India. Article Received: 12/03/2013 Revised: 29/03/2013 Accepted: 30/03/2013 ABSTRACT *For Correspondence: Two novel series of mesoionic compounds containing benzothiazole and thiazole based sydnone derivatives were synthesized. All the synthesized compounds Department of Chemistry, Veer have been characterized by physical methods (melting point, TLC and elementary Narmad South Gujarat University, analysis) and by spectral techniques (IR, 1H NMR and 13C NMR). Udhna-Magdalla Road, Surat - 395007 (Gujarat) India. Keywords: Synthesis, Benzothiazole, Thiazole, Sydnone. INTRODUCTION The effectiveness of mesoionic compounds as a chemotherapeutic agent is well established [1,2,3,4] and their chemistry has been studied. A literature survey revealed that sydnones display potent biological activity [5,6,7,8,9]. Feprosidnine (sydnophen) is a CNS- stimulant drug in which the sydnone imine group is found as sub-structure [10]. Sydnones occupy a unique place among mesoionic compounds [11]. The sydnone ring displays electron-withdrawing character at N3 and electron-donating properties at C4.
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