Molbank 4 -(N-(Propan-1,2-Dienyl)Pyrrol-2-Yl)-2,2 : 6 , 2”-Terpyridine Jérôme Husson, Laurent Guyard
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molbank 4 -(N-(Propan-1,2-dienyl)pyrrol-2-yl)-2,2 : 6 , 2”-terpyridine Jérôme Husson, Laurent Guyard To cite this version: Jérôme Husson, Laurent Guyard. molbank 4 -(N-(Propan-1,2-dienyl)pyrrol-2-yl)-2,2 : 6 , 2”- terpyridine. Molbank, MDPI, 2020, 2020 (2), pp.M1142. 10.3390/M1142. hal-02868004 HAL Id: hal-02868004 https://hal.archives-ouvertes.fr/hal-02868004 Submitted on 19 Sep 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution - NoDerivatives| 4.0 International License molbank Short Note 0 0 4Short-( NoteN-(Propan-1,2-dienyl)pyrrol-2-yl)-2,2 : 0 64’-(N-(propan-1,2-dienyl)pyrrol-2-yl)-2,2’:6’,2’’-, 2”-terpyridine terpyridine. Jérôme Husson * and Laurent Guyard Jérôme Husson * and Laurent Guyard Institut UTINAM UMR CNRS 6213, UFR Sciences et Techniques, Université de Bourgogne-Franche-Comté, 16Institut Route UTINAM de Gray, 25030UMR CNRS Besançon 6213, CEDEX, UFR Sciences France; et [email protected] Techniques, Université de Bourgogne-Franche-Comté, *16Correspondence: route de Gray, 25030 [email protected]; Besançon cedex, France; [email protected] Tel.: +33-3-81666291 * Correspondence: [email protected]; Tel.: +33-3-81666291 Received: 5 March 2020; Accepted: 10 June 2020; Published: date 10 June 2020 Abstract: A new pyrrole-substituted terpyridine derivative that possesses an allene moiety was Abstract: A new pyrrole-substituted terpyridine derivative that possesses an allene moiety was obtained as an “unexpected” sole product during an attempt to alkylate the N-atom of pyrrole with obtained as an “unexpected” sole product during an attempt to alkylate the N-atom of pyrrole with propargyl bromide in order to obtain an alkyne-functionalized terpyridine. propargyl bromide in order to obtain an alkyne-functionalized terpyridine. Keywords: ligand; pyridine derivatives; allenic compounds; N-alkylation Keywords: ligand; pyridine derivatives; allenic compounds; N-alkylation. 1. Introduction Terpyridine ligands (terpy) (terpy) and and their their complexes complexes have have been been widely widely studied studied [1]. This [1]. can This be can easily be easilyexplained explained by the by huge the hugenumber number of terpyridine of terpyridine der derivativesivatives that that can can be be obtained obtained by by varying varying the substitution patternpattern of of the the ligand ligand as well as aswell the natureas the ofnature the complexed of the complexed metal. In particular, metal. In terpyridines particular, thatterpyridines contain athat five contain membered a five heterocycle, membered such heterocycle, as furan [2such] or thiopheneas furan [2] [3 ],or have thiophene attracted [3], a lothave of attention.attracted a In lot fact, of attention. they can beIn usedfact, they as intermediates can be used inas theintermediates preparation in of the materials preparation for solar of materials cells [4] orfor nanoparticles solar cells [4] [5 ],or as nanoparticles biological probes [5], [6as], asbiologic ligandsal inprobes catalysis [6], [7 ],as as ligands antimicrobial in catalysis agents [7], [8], as electrochromicantimicrobial agents materials [8], [as9] orelectrochromic as chromophores material [10],s to[9] name or as just chromophores a few applications. [10], to Althoughname just aa little few lessapplications. studied, terpyridinesAlthough a thatlittle includeless studied, a pyrrole terpyridin ring havees that also include been a subjecta pyrrole of interest.ring have For also example, been a suchsubject terpyridines of interest. have For example, been used such for theterpyridines preparation have of cytotoxicbeen used molecules for the preparation [11], for application of cytotoxic in OLEDmolecules (organic [11], for light application emitting diodes)in OLED [12 (organic] or sensor light devices emitting [13 diodes)] or for [12] the or preparation sensor devices of catalytic [13] or materialsfor the preparation [14]. Thus, of the catalytic preparation materials of terpyridine [14]. Thus, derivatives the preparation that contain of terpyridine a functionalized derivatives pyrrole that iscontain of interest a functionalized in the fields ofpyrrole both organicis of interest synthesis in the and fields material of both science. organic This synthesis article describes and material how pyrrole-containingscience. This article terpyridine describes how1 was pyrrole-containing obtained as an unexpected terpyridine product 1 was duringobtained attempts as an unexpected to prepare compoundproduct during2 (Figure attempts1), which to prepare features compound an alkyne chain 2 (Figure for possible 1), which future features functionalization an alkyne chain [15]. for possible future functionalization [15]. Figure 1. Structures of terpyridine compounds (1) and (2). Figure 1. Structures of terpyridine compounds (1) and (2). 2. Results and Discussion 2. Results and Discussion The synthetic approach towards molecule 2 relies on the N-alkylation of the pyrrole moiety of 40-(pyrrol-2-yl)-2,2The synthetic 0approach:60,2”-terpyridine towards ( 3molecule) with propargyl 2 relies on bromide the N-alkylation (Figure2), applyingof the pyrrole a protocol moiety that of has4’-(pyrrol-2-yl)-2,2’:6’,2’’-terpyridine been described for the preparation (3 of) with N-alkyl propargyl terpyridine bromide pyrroles (Figure [16 ].2), At applying the end a of protocol the reaction, that has been described for the preparation of N-alkyl terpyridine pyrroles [16]. At the end of the reaction, Molbank 2020, 2020, M1142; doi:10.3390/M1142 www.mdpi.com/journal/molbank Molbank 2020, 2020, M9xx; doi: www.mdpi.com/journal/molbank Molbank 2020, 2020, M1142 2 of 5 Molbank 2020, 2020, M9xx 2 of 5 Molbank 2020, 2020, M9xx 2 of 5 a single single productproduct waswaswas noticed noticednoticed by byby TLC. TLC.TLC. This ThisThis product productproduct was waswas easily easilyeasily separated separatedseparated from fromfrom the thethe starting startingstarting material materialmaterial by 1 1 byflashby flashflash chromatography, chromatography,chromatography, but butbutH NMR1HH NMRNMR did diddid not notnot agree agreeagree with withwith the thethe structure structurestructure of 2 ofof. 22.. Figure 2. Synthetic pathway that afforded compound 1. FigureFigure 2.2. SyntheticSynthetic pathwaypathway thatthat affordedafforded compoundcompound 11.. Instead, structure 1 was coherent with 1H NMR. In particular, the spectrum exhibits the signals Instead, structure 1 was coherent with 1H NMR. In particular, the spectrum exhibits the signals for theInstead, allenic structure protons. 1 In was fact, coherent a triplet with is observed 1H NMR. at In 7.14 particular, ppm (J = the6.4 spectrum Hz). This exhibits signal accounts the signals for for the allenic protons. In fact, a triplet is observed at 7.14 ppm (J= 6.4 Hz). This signal accounts for thefor allenicthe allenic proton protons.e (Figure In 3fact,). In a addition, triplet is aobserved doublet isat observed 7.14 ppm at (J= 5.50 6.4 ppm Hz). ( JThis= 6.4 signal Hz) for accounts the allenic for the allenic proton e (Figure 3). In addition, a doublet is observed at 5.50 ppm (J= 6.4 Hz) for the allenic protonsthe allenicg. proton These multiplicitiese (Figure 3). In and addition, chemical a doublet shifts areis observed in accordance at 5.50 withppm those(J= 6.4 reportedHz) for the for allenic other protons g. These multiplicities and chemical shifts are in accordance with those reported for other allene-functionalizedprotons g. These multiplicities pyrroles [ 17and–19 chemical]. shifts are in accordance with those reported for other allene-functionalizedallene-functionalized pyrrolespyrroles [17-19].[17-19]. Figure 3. 1H NMR spectra of compound 1 (inset: structure and atom numbering of 1). 1 FigureFigure 3.3. 1HH NMRNMR spectraspectra ofof compoundcompound 11 (inset:(inset: structurestructure andand atomatom numberingnumbering ofof 11)).. All other signals arising from the terpyridine and the pyrrole parts of the molecule are present. 13 Additionally,AllAll otherother the signalssignals structure arisingarising of 1 fromwasfrom further thethe terpyridineterpyridine confirmed andand by Supplementary thethe pyrrolepyrrole partsparts Materials ofof thethe moleculemoleculeC NMR, are asare well present.present. as by 13 13 Additionally,HR-MS.Additionally, For instance, thethe structurestructure the ofofC 1 NMR1 waswas further spectrumfurther confirmedconfirmed features by 15by signals13CC NMR,NMR, due asas to wellwell the asas symmetry byby HR-MS.HR-MS. of FortheFor molecule,instance,instance, 13 + thewhilethe 13CC mass NMRNMR spectra spectrumspectrum exhibit featuresfeatures the molecular 1515 signalssignals ion duedue peak toto at thethe 337.14466 symmetrysymmetry (calc. ofof for thethe [C molecule,molecule,22H16N4 + whilewhileH] : 337.14477).massmass spectraspectra exhibit the molecular ion peak at 337.14466 (calc. for [C22H16N4+H]+ : 337.14477). exhibitAs the pointed molecular out inion the peak above-mentioned at 337.14466 (calc. literature,