University of Groningen Steps Towards De-Novo Life Monreal Santiago
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University of Groningen Steps towards de-novo life Monreal Santiago, Guillermo DOI: 10.33612/diss.121581426 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2020 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Monreal Santiago, G. (2020). Steps towards de-novo life: compartmentalization and feedback mechanisms in synthetic self-replicating systems. University of Groningen. https://doi.org/10.33612/diss.121581426 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 27-09-2021 About the author Guillermo Monreal Santiago was born in 1992 in Madrid, Spain. He pursued his undergraduate studies at the Universidad Complutense de Madrid (UCM), where he received a Bachelor’s degree in Chemistry (2014) and a Masters de- gree in Organic Chemistry (2015). His undergraduate research projects consisted on the synthesis of biologically active b-aminoalcohols from enantioenriched O- acylated cyanohydrins (under the supervision of Christina Moberg, at KTH in Stockholm), and the synthesis of Fe-Fe polymetallic clusters bound to nucleobases as hydrogenase mimics (under the supervision of Mar Gómez Gallego and Miguel Ángel Sierra, in the bioorganometallic group at the UCM). He moved to Gronin- gen in 2015 to pursue a PhD in the group of Sijbren Otto, researching the com- bination of life-like properties with synthetic self-replicators emerging from dy- namic combinatorial libraries. The results of his PhD research are described in this thesis. List of publications [1] Matysiak, B. M.; Monreal Santiago, G.; Otto, S. Teaching an old compound new tricks: Reversible transamidation in maleamic acids. In preparation [2] Maity, S.; Ottelé, J.; Monreal Santiago, G.; Frederix, P. W.; Kroon, P. C.; Markovitch, O.; Stuart, M. C. A.; Marrink, S. J.; Otto, S.; Roos, W. H. Caught in the act: Mechanism of supramolecular polymerization driven self-replication visualized in real time. Submitted. [3] Monreal Santiago, G.; Liu, K.; Browne, W. R.; Otto, S. Emergence of light- driven protometabolism upon recruitment of a photocatalytic cofactor by a self-replicator. Nat. Chem. 2020, Accepted. Preprint – doi: 10.26434/chem- rxiv.10002122.v1. [4] Komaromy, D.; Tiemersma-Wegman, T.; Kemmink, J.; Portale, G.; Aalbers, F.; Mari´c,I.; Monreal Santiago, G.; Ottelé, J. O.; Sood, A.; Saggiomo, V.; Liu, B.; van der Meulen, P.; Otto, S. Controlling supramolecular plasticity through stoichiometry. ChemRxiv 2019, doi: 10.26434/chemrxiv.10117343.v1. [5] Bartolec, B.; Leonetti, G.; Li, J.; Smit, W.; Altay, M.; Monreal Santiago, G.; Yan, Y.; Otto, S. Emergence of compartments formed from unconventional surfactants in dynamic combinatorial libraries. Langmuir 2019, 35, 5787–5792. 183 [6] Malakoutikhah, M.; Schaeffer, G.; Monreal Santiago, G.; Yang, S.; Mari´c,I.; Otto, S. Cross-catalysis between self-replicators of different handedness. J. Syst. Chem. 2019, 7. [7] Cvrtila, I.; Fanlo-Virgós, H.; Schaeffer, G.; Monreal Santiago, G.; Otto, S. Re- dox control over acyl hydrazone photoswitches. J. Am. Chem. Soc. 2017, 139, 12459–12465. [8] Komáromy, D.; Stuart, M. C.; Monreal Santiago, G.; Tezcan, M.; Kras- nikov, V. V.; Otto, S. Self-assembly can direct dynamic covalent bond forma- tion toward diversity or specificity. J. Am. Chem. Soc. 2017, 139, 6234–6241. [9] Hertzberg, R.; Monreal Santiago, G.; Moberg, C. Synthesis of the β3- adrenergic receptor agonist Solabegron and analogous N-(2-Ethylamino)-β- amino alcohols from O-acylated cyanohydrins - expanding the scope of mi- nor enantiomer recycling. J. Org. Chem. 2015, 80, 2937–2941. 184.