University of

Steps towards de-novo life Monreal Santiago, Guillermo

DOI: 10.33612/diss.121581426

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Publication date: 2020

Link to publication in /UMCG research database

Citation for published version (APA): Monreal Santiago, G. (2020). Steps towards de-novo life: compartmentalization and feedback mechanisms in synthetic self-replicating systems. University of Groningen. https://doi.org/10.33612/diss.121581426

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Download date: 27-09-2021 About the author

Guillermo Monreal Santiago was born in 1992 in Madrid, Spain. He pursued his undergraduate studies at the Universidad Complutense de Madrid (UCM), where he received a Bachelor’s degree in (2014) and a Masters de- gree in Organic Chemistry (2015). His undergraduate research projects consisted on the synthesis of biologically active β-aminoalcohols from enantioenriched O- acylated cyanohydrins (under the supervision of Christina Moberg, at KTH in Stockholm), and the synthesis of Fe-Fe polymetallic clusters bound to nucleobases as hydrogenase mimics (under the supervision of Mar Gómez Gallego and Miguel Ángel Sierra, in the bioorganometallic group at the UCM). He moved to Gronin- gen in 2015 to pursue a PhD in the group of Sijbren Otto, researching the com- bination of life-like properties with synthetic self-replicators emerging from dy- namic combinatorial libraries. The results of his PhD research are described in this .

List of publications

[1] Matysiak, B. M.; Monreal Santiago, G.; Otto, S. Teaching an old compound new tricks: Reversible transamidation in maleamic acids. In preparation

[2] Maity, S.; Ottelé, J.; Monreal Santiago, G.; Frederix, P. W.; Kroon, P. C.; Markovitch, O.; Stuart, M. C. A.; Marrink, S. J.; Otto, S.; Roos, W. H. Caught in the act: Mechanism of supramolecular polymerization driven self-replication visualized in real time. Submitted.

[3] Monreal Santiago, G.; Liu, K.; Browne, W. R.; Otto, S. Emergence of light- driven protometabolism upon recruitment of a photocatalytic cofactor by a self-replicator. Nat. Chem. 2020, Accepted. Preprint – doi: 10.26434/chem- rxiv.10002122.v1.

[4] Komaromy, D.; Tiemersma-Wegman, T.; Kemmink, J.; Portale, G.; Aalbers, F.; Mari´c,I.; Monreal Santiago, G.; Ottelé, J. O.; Sood, A.; Saggiomo, V.; Liu, B.; van der Meulen, P.; Otto, S. Controlling supramolecular plasticity through stoichiometry. ChemRxiv 2019, doi: 10.26434/chemrxiv.10117343.v1.

[5] Bartolec, B.; Leonetti, G.; Li, J.; Smit, W.; Altay, M.; Monreal Santiago, G.; Yan, Y.; Otto, S. Emergence of compartments formed from unconventional surfactants in dynamic combinatorial libraries. Langmuir 2019, 35, 5787–5792.

183 [6] Malakoutikhah, M.; Schaeffer, G.; Monreal Santiago, G.; Yang, S.; Mari´c,I.; Otto, S. Cross- between self-replicators of different handedness. J. Syst. Chem. 2019, 7. [7] Cvrtila, I.; Fanlo-Virgós, H.; Schaeffer, G.; Monreal Santiago, G.; Otto, S. Re- dox control over acyl hydrazone photoswitches. J. Am. Chem. Soc. 2017, 139, 12459–12465. [8] Komáromy, D.; Stuart, M. C.; Monreal Santiago, G.; Tezcan, M.; Kras- nikov, V. V.; Otto, S. Self-assembly can direct dynamic covalent bond forma- tion toward diversity or specificity. J. Am. Chem. Soc. 2017, 139, 6234–6241. [9] Hertzberg, R.; Monreal Santiago, G.; Moberg, C. Synthesis of the β3- adrenergic receptor agonist Solabegron and analogous N-(2-Ethylamino)-β- amino alcohols from O-acylated cyanohydrins - expanding the scope of mi- nor enantiomer recycling. J. Org. Chem. 2015, 80, 2937–2941.

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