Journal of Clinical and Translational Research 10.18053/Jctres/07.202101.012 REVIEW Multiple sclerosis in Iran: An epidemiological update with focus on air pollution debate Masoud Amiri* Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands *Corresponding author Masoud Amiri Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands Email:
[email protected] Article information: Received: October 5, 2020 Revised: December 18, 2020 Accepted: January 13, 2021 Journal of Clinical and Translational Research 10.18053/Jctres/07.202101.012 Abstract Background: Multiple sclerosis (MS), as the most common neurologic disorder of the central nervous system (CNS), with growing incidence and prevalence worldwide and in the Middle East. This article aimed to find out the potential relationship between MS and air pollution in Iran. Methods: By assessing the published articles on MS and air pollution in Iran, the situation of MS as well as air/soil pollution in Iran was clarified. Then, studies on air pollution and its potential effect on Iranian MS patients were checked until 2020. Results: The MS prevalence is distributed across Iran provinces with highest rates in Isfahan, located in the center of Iran. The higher rates of MS in Isfahan and Tehran (the Metropolitan) might be due to industrial pollution of these cities, but this hypothesis is not true for non-industrial provinces.