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1 Alkermes Public Limited Company Directors' Report ALKERMES PUBLIC LIMITED COMPANY DIRECTORS’ REPORT AND CONSOLIDATED FINANCIAL STATEMENTS For the Financial Year Ended December 31, 2020 Registered Company Number: 498284 1 ALKERMES PUBLIC LIMITED COMPANY DIRECTORS’ REPORT AND CONSOLIDATED FINANCIAL STATEMENTS TABLE OF CONTENTS Directors’ Report................................................................................................................................................................... 3 Statement of Directors’ Responsibilities............................................................................................................................... 57 Independent Auditors’ Report—Group and Company ......................................................................................................... 58 Consolidated Profit and LossAccount.................................................................................................................................. 64 Consolidated Statement of Comprehensive Loss.................................................................................................................. 65 Consolidated Balance Sheet .................................................................................................................................................. 66 Consolidated Statement of Cash Flows................................................................................................................................. 67 Consolidated Reconciliation of Movement in Shareholders’ Funds..................................................................................... 68 Notes to the Consolidated Financial Statements ................................................................................................................... 69 Company Balance Sheet........................................................................................................................................................ 111 Company Reconciliation of Movement in Shareholders’ Funds .......................................................................................... 112 Notes to the Company Financial Statements......................................................................................................................... 113 2 DIRECTORS’ REPORT For the Financial Year Ended December 31, 2020 The directors present their report and theaudited consolidated financial statements and related notes of Alkermes Public Limited Company (“Alkermes plc”) for the year ended December 31, 2020. Irish law requiresthe directors to prepare financial statements for each financial year thatgiveatrue and fair viewofthe consolidated and company’s assets, liabilities and financial position as at the end of the financial year and of the profitorloss of the group for the financial year. Under that law, the directors have prepared the consolidated financial statements in accordance with U.S. accounting standards, as defined in Section 279(1) of the Companies Act 2014, as amended (the “Companies Act”), to the extent that the use of those principles in the preparation of the financial statements does not contravene any provision of the Companies Act or of any regulations made thereunder and the parent company financial statements in accordance with generally accepted accounting practice in Ireland(accounting standards issued by the Financial Reporting Council and Irish law). NOTE REGARDING COMPANY AND PRODUCT REFERENCES Use of terms such as “us,” “we,” “our,” “Alkermes” or the “Company” in this Directors’ Report is meant to refer to Alkermes plc and its consolidated subsidiaries. Except as otherwise suggested by the context, (a) references to “products” or “our products” in thisDirectors’ Report include our marketed products, marketed productsusing our proprietary technologies, our product candidates and product candidates using our proprietary technologies (b) references to the “biopharmaceutical industry” in thisDirectors’ Report are intended to include reference to the “biotechnology industry” and/or the “pharmaceutical industry” and (c) references to “licensees” in this Directors’ Report are used interchangeably with references to “partners.” NOTE REGARDING TRADEMARKS We are the owner of various United States (“U.S.”) federal trademark registrations (“®”) and other trademarks (“TM”), including ALKERMES®,ARISTADA®,ARISTADA INITIO®,LinkeRx®,LYBALVITM,NanoCrystal®,and VIVITROL®. The following are trademarks of the respective companies listed:ABILIFY® and ABILIFY MAINTENA®—Otsuka Pharmaceutical Co., Ltd. (“Otsuka Pharm. Co.”); AMPYRA® and FAMPYRA®—Acorda Therapeutics, Inc. (“Acorda”); ANTABUSE®—Teva Women’s Health, Inc.; AUBAGIO® and LEMTRADA®—Sanofi Societe Anonyme France; AVONEX®,PLEGRIDY®,TECFIDERA®,TYSABRI® and VUMERITY®—Biogen MA Inc. (together with itsaffiliates, “Biogen”); BETASERON®—Bayer Pharma AG; BUNAVAILTM—BioDelivery Sciences; CAMPRAL®—Merck Sante; CAPLYTA®—Intra-Cellular Therapies, Inc.; COPAXONE®—Teva Pharmaceutical Industries Ltd.; EXTAVIA®, GILENYA®,and MAYZENT®—Novartis AG; INVEGA SUSTENNA®,INVEGATRINZA®,TREVICTA®,XEPLION® and RISPERDAL CONSTA®—Johnson &Johnson (or its affiliates); LATUDA®—Sumitomo Dainippon Pharma Co., Ltd.; MAVENCLAD®—Merck KGaA, REBIF®—Ares Trading S.A.; OCREVUS®—Genentech, Inc. (“Genentech”); REXULTI®—H.Lundbeck A/S plc; PERSERIS®,SUBOXONE®,SUBUTEX® and SUBLOCADE®—Indivior plc (or its affiliates); VRAYLAR®—Forest Laboratories, LLC; ZEPOSIA®—Bristol-Myers Squibb Company; ZUBSOLV®—Orexo US, Inc.; and ZYPREXA® and ZYPREXA RELPREVV®—Eli Lilly and Company (“Lilly”). Other trademarks, trade names and service marks appearing in this Directors’ Report are the property of their respective owners. Solely for convenience, the trademarks and trade names in this Directors’ Report are referred to without the ® and TM symbols, but such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. CAUTIONARY NOTE CONCERNING FORWARD-LOOKING STATEMENTS This document contains and incorporates by reference “forward-looking statements” within the meaning of thePrivate Securities Litigation Reform Act of 1995, as amended. In some cases, these statements can be identified by the use of forward-looking terminology such as “may,” “will,” “could,” “should,” “would,” “expect,” “anticipate,” “continue,” “believe,” “plan,” “estimate,” “intend,” or other similar words.These statements discuss future expectations and contain projections of results of operations or of financial condition, or state trends and known uncertainties or other forward-looking information. Forward-looking statements in thisDirectors’ Report include, without limitation, statements regarding: •our expectations regarding our financial performance, includingrevenues, expenses, liquidity, capital expenditures and income taxes; •our expectations regarding our products, including those expectations related toproduct development, regulatory filings, regulatory approvals and regulatory timelines, therapeutic and commercial scope and potential, and thecosts and expenses related to such activities; •our expectations regarding the initiation, timing and results of clinical trialsofour products; 3 •our expectations regarding the competitive, payer, legislative,regulatory and policy landscapes, and changes therein, related to our products, including competition from generic forms of our products or competitive products and competitive development programs, barriers to accessorcoverage of our products and changes in reimbursement of our products, and legislation, regulations, executive orders, guidanceorother measures that may limit pricing and reimbursement of, and access to, our products; •our expectations regarding the financial impact of currency exchange rate fluctuations and valuations; •our expectations regarding future amortization of intangible assets; •our expectations regarding our collaborations, licensing arrangements and other significant agreements with third parties relating to our products, including our development programs; •our expectations regarding the impact of new legislation, rules, regulations and the adoption of new accounting pronouncements; •our expectations regarding near-term changes in the nature of our market risk exposures or in management’s objectives and strategies with respect to managing such exposures; •our expectations regarding our ability to comply with restrictive covenants of our indebtedness and our ability to fund our debt service obligations; •our expectations regarding future capital requirements and capital expenditures and our ability to finance our operations and capital requirements; •our expectations regarding the timing, outcome and impact of administrative, regulatory, legal and other proceedings related to our products and intellectual property (“IP”), including our patents; •our expectations regarding the impact of the ongoing novel coronavirus (“COVID-19”) pandemic on our business and operations; and •other factors discussed elsewhere in this Directors’ Report. Actual results might differ materially from those expressed or implied by these forward-looking statements because these forward-looking statements are subject to risks, assumptions and uncertainties. In light of these risks, assumptions and uncertainties, the forward-looking eventsdiscussed in this Directors’ Report might not occur. You are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date of this Directors’
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