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Prevalence and Pattern of Skin Diseases in Patients with Diabetes Mellitus at a Tertiary Hospital in Northern Nigeria H Sani, AB Abubakar, AG Bakari1

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Prevalence and Pattern of Skin Diseases in Patients with Diabetes Mellitus at a Tertiary Hospital in Northern Nigeria H Sani, AB Abubakar, AG Bakari1 [Downloaded free from http://www.njcponline.com on Monday, July 6, 2020, IP: 197.90.36.231] Original Article Prevalence and Pattern of Skin Diseases in Patients with Diabetes Mellitus at a Tertiary Hospital in Northern Nigeria H Sani, AB Abubakar, AG Bakari1 Department of Medicine, Background: Diabetes mellitus is one of the most common metabolic disorders Barau Dikko Teaching with a rising prevalence. It cuts across all ages and socioeconomic status. Various Hospital, Kaduna State University, Kaduna, skin lesions are frequently observed in diabetic patients. Aims: This study was 1Department of Medicine, carried out to determine the prevalence, pattern, and determinants of skin diseases Ahmadu Bello University Abstract in diabetic patients at the Barau Dikko Teaching Hospital, Kaduna, North West Teaching Hospital, Zaria, Nigeria. Materials and Methods: One hundred consecutive diabetic patients Nigeria attending the clinic were included in the study. Results: Many of the patients had more than one skin condition at a time. The most prevalent skin diseases were idiopathic guttate hypomelanosis which was seen in 61% of patients, infections from fungal, bacterial, and viral causes occurred in 30% of patients, other skin Received: 14-Feb-2019; disorders were diabetic dermopathy seen in 17% of patients, palmoplantar Revision: hyperpigmentation was seen in 13% of patients, while pruritus occurred in 12% 24-Mar-2020; of patients and xerosis was seen in 10% of patients. Conclusion: Skin disorders Accepted: are common among diabetic patients at Barau Dikko Teaching Hospital, Kaduna, 13-Apr-2020; North West Nigeria. Published: 03-Jul-2020 Keywords: Cutaneous manifestations, diabetes mellitus, pattern, prevalence Introduction determine the factors associated with the skin diseases iabetes mellitus is one the most common metabolic and assess the relationship between skin diseases and Ddisorders that occurs in all ages, races, and glycemic control. socioeconomic strata. The prevalence and incidence of diabetes is rising and affects about 5–7% of the Materials and Method population in sub‑Saharan Africa.[1] This was a cross‑sectional study conducted at the medical outpatient clinic of the Barau Dikko Teaching There is a wide variation in the prevalence and pattern Hospital, Kaduna, North‑Western Nigeria. Ethical of skin disorders in diabetic individuals depending on approval and informed consent were obtained from the region, and the overall prevalence ranges between the ethical committee of the Hospital and respondents [2‑4] 51.1% and 97%. respectively before commencement of the study. It has been suggested that skin changes may be due to One hundred consecutive diabetic patients attending the the effects of advanced glycation end products, oxidative clinic were included in the study. Diagnosis of diabetes stress and inflammation which leads to early skin aging, mellitus was based on WHO criteria of fasting plasma development of diabetic dermopathy, and scleroderma glucose of >7 mmol/l (126 mg/dl) and or random [5] diabeticorum. Similarly, skin lesions like acanthosis plasma glucose >11.1 mmol/l (200 mg/dl) on at least nigricans, acrochordons, and inflammatory dermatitis may result from hormonal influences, insulin resistance, Address for correspondence: Dr. H Sani, imbalance growth factors and cytokines.[4,5] Department of Medicine, Barau Dikko Teaching Hospital, Kaduna State University, Kaduna, Nigeria. The aim of the study was to determine the prevalence E‑mail: [email protected] and pattern of skin diseases in diabetic patients, to This is an open access journal, and articles are distributed under the terms of the Access this article online Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as Quick Response Code: Website: www.njcponline.com appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: [email protected] DOI: 10.4103/njcp.njcp_95_19 How to cite this article: Sani H, Abubakar AB, Bakari AG. Prevalence and PMID: ******* pattern of skin diseases in patients with diabetes mellitus at a tertiary hospital in Northern Nigeria. Niger J Clin Pract 2020;23:970-4. 970 © 2020 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer - Medknow [Downloaded free from http://www.njcponline.com on Monday, July 6, 2020, IP: 197.90.36.231] Sani, et al.: Prevalence and pattern of skin diseases in patients with Diabetes mellitus two occasions. Good control was fasting plasma glucose Table 1: Clinical and Demographic Characteristics of of <6 mmol/l and poor control was fasting plasma 100 Diabetics Studied glucose of >6 mmol/l. Character frequencies Percentage (%) Records of the patients’ age, sex, fasting blood sugar, Gender body mass index, and duration of diabetes were Male 22 22 Female 78 78 documented. An evaluation of the skin disease was made Total 100 100 clinically after detailed examination. Data was analyzed Age (years) using statistical package for social sciences version 21. 0‑20 01 01 Data cleaning was carried out and errors corrected. 21‑40 15 15 Quantitative variables were summarized using means 41‑60 47 47 and standard deviation while frequencies and proportions 61‑80 37 37 were used for qualitative variables. Student’s t‑test Total 100 100 was used to test statistical significance for continuous BMI (Kg/m2) variables while association between alopecia and hair <18.5 09 09 care practices was tested using Chi‑square test. The 18.5‑24.9 31 31 level of statistical significance was at P ≤ 0.05. 25.0‑29.9 27 27 >30 23 23 Results Total 100 100 FBS (mmol/l) A total of 100 diabetic subjects were involved in the <6 24 24 study. Majority of the participants were females 78 (78%). >6 76 76 The youngest patient was 16 years and the oldest was Total 100 100 80 years with a mean age of 55.90 ± 13.11 years. Only Duration of Diabetes mellitus (years) 0‑10 72 72 11‑20 24 24 >20 04 04 Total 100 100 Figure 1: Idiopathic guttate hypomelanosis Figure 2: Tinea pedis Figure 3: Diabetic dermopathy Figure 4: Candidal paronychia and onychomycosis Nigerian Journal of Clinical Practice ¦ Volume 23 ¦ Issue 7 ¦ July 2020 971 [Downloaded free from http://www.njcponline.com on Monday, July 6, 2020, IP: 197.90.36.231] Sani, et al.: Prevalence and pattern of skin diseases in patients with Diabetes mellitus Table 2: Types of skin lesions and its prevalence seen Table 4: Relationship between age and Idiopathic guttate among 100 diabetic patients in Kaduna hypomelanosis (IGH) in 100 Diabetics in Kaduna Type of skin lesion Percentage AGE (YRS) IGH PRESENT IGH ABSENT Idiopathic gutate hypomelanosis 61 0‑40 5 11 Superficial fungal infections 26 41‑80 56 28 Diabetic dermopathy 17 TOTAL 61 39 Palmo plantar hyperpigmentation 13 X2=13.112 df =1 Pruritus 12 P value=0.000 Xerosis 10 Dermatosis papulosa nigra 7 Ichthyosis 3 Table 5: Relationship between FBS and Tinea pedis in Diabetic thick skin 3 100 Diabetics in Kaduna Atopic dermatitis 3 FBS Tinea pedis ‑ Present Tinea pedis - Absent Pincer nails 3 Less than 6 5 19 Vitiligo 2 Greater than 6 9 67 Calluses 2 Total 14 86 Furuncles 2 X2=1.212 df =1 Koilonychia 2 P value=0.271 Warts 2 Acne keloidalis nuchae 2 The various types of skin lesions and their Ulcer 2 prevalence are shown in Table 2. Table 3 shows the Acanthosis nigricans 1 different types of skin infections. Idiopathic guttate Melasma 1 hypomelanosis (IGH) had a strong relationship with Terrys nails 1 increasing age (P < 0.000) as shown in Table 4. There Skin tag 1 was no correlation between infections like Tinea pedis Eruptive xanthomas 1 and blood sugar levels (P > 0.271) as shown in Table 5. Melanonychia 1 Discussion Table 3: Types of skin infections seen in 100 Diabetic Cutaneous changes in diabetics may precede or appear patients in Kaduna at the time of diagnosis of diabetes mellitus. Some of Type of skin infections Number of patients these lesions are strongly associated with diabetes Fungal infections mellitus; such lesions include diabetic dermopathy, Tinea pedis 14 diabetic bullae, and necrobiosis lipoidica. On the other Tinea corporis 1 Tinea unguium 2 hand, some other skin changes observed in people living [4‑7] Vagina candiasis 4 with diabetes are associated with infection. Candida paronychia 1 Ninety‑two (92%) of the subjects in this study had Pityriasis versicolor 4 skin lesions. Previous studies have shown that 30–71% Bacterial infections of diabetics have skin disorders.[6,7] The finding in this Furuncles 2 study is comparable to some previous studies where Viral infections [8] Warts 2 Hajieh et al. found a prevalence of 92%. In a study by Abhishek et al.,[9] he noted that 80% of the 100 diabetics studied had more than one form of skin lesion. Similar 31 (34.4%) respondents had normal BMI (18.5 ‑24.9), studies from Nigeria by Onunu[10] and Ezejiofor et al.[11] 9 (10%) subjects were under weight, 27 (30.0%) subjects both in the tropical rain forest region of Nigeria reported were overweight and 23 (25.6%) were obese. prevalence rates of 63.2% and 73%, respectively. Most of the subjects 76 (76%) had poor glycemic The higher prevalence in the study compared to those control with a fasting plasma glucose of more than 6.0 from the tropical rain forest area may be attributable mmol/l while the remaining 24 (24%) had good control to climatic differences as the tropical savannah in with a value of less than 6.0 mmol/l. Seventy‑two (72%) north west Nigeria experiences more sunshine and of the subjects had diabetes mellitus for less than higher temperatures than in the rain forest areas. It is 10 years, 24% had diabetes for a period of between 11 noteworthy that the higher overall prevalence of skin and 20 years, only 4% had been diabetic for more than diseases in diabetics observed in our study is accounted 20 years [Table 1].
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