Volume 5, Issue 6, June – 2020 International Journal of Innovative Science and Research Technology ISSN No:-2456-2165 Formulation of Sea Buckthorn Diabo Juice on Treatment of Diabetes

Akshay S Jadhav*, Pallavi S Kale*, Vaishnavi N Pankade*, Snehal A Kardule*, Shubhangi B Hase*, Jyoti V Shelke*, Shweta R Thorat, Sonali B Argade* *Pratibhatai pawar college of pharmacy wadala mahadev, Shrirampur University – D Batu Lonere, Raigad

Abstract:- Now days lot of diabetic medicine are extract helps to pancreas to maintain healthy blood sugar available in market having chemical substance. They level. jamun helps control the blood sugar level in our have lots of side effect but now days lot of anti diabetic body. the herb punarnava in Ayurveda is very useful in medicines are available but sometimes they does not rejuvenating the body and in sugar management. the bael show effect on same patient. Their bodies does not extract poses Anti-hyperglycemic activity as evidenced by stimulate B-pancreatic cells in bodies which are insulin lowering blood glucose level in streptozotocin induced production. diabetic rats (STZ-S). The neem helps the regulate blood sugar level and Aloe Vera used as a preservative. To overcome this problems by using anti diabetic herbal formulation. It is effective, safe to use It maintain blood II. THE PRODUCT CONTAINS sugar level , Regulate the blood flow, It has anti diabetic , antioxidant , anticancer, anti microbial and anti- A. Sea buckthorn inflammatory properties without any side effect. B. Punarnava extract C. Karela extract Keywords:- Sea buckthorn, Medicinal research, Effective D. Jamun extract constituent, Safe to use ,Anti-diabetic, Regulate the blood E. Bael extract flow. F. Neem extract G. Aloe Vera I. INTRODUCTION A. Sea Buckthorn : The fruits of sea buckthorn ( Hippophae rhamnoidses Common name: Sea buck thorn L. )hare been used as a drug by traditional Tibetan and Scientific name: Hippophae rhamnoides Mongolian medicine since ancient times. It has Clade :Tracheophytes pharmacological effect of the blood circulation, the lungs, Clade :Angiosperms the stomach the spleen. Now days this fruit has more value. Clade :Eudicots Kingdom :Plantae This sea buckthorn diablo juice is prepared with Division: Tracheophyta certified organic sea buckthorn berries and also formulated Class :Dicotyledons with punarnava extract, karela extract, Jamun extract Bael Order: Rosales extract, and Neem extract. It provides more than 190 Family :Elaeagnaceae bioactive compounds to our body along with fatty acids, Genus :Hippophae omega 3, 6, 7 & 9. According to scientific studies karela Species. : H. rhamonoids

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Fig 1

Sea buck thorn is commonly known as Hippophae  Anti inflammation effect rhamnoides. Sea buckthorn thrives in the harsh conditions  Inhibit cholesterol deposition and high altitude of the Himalayas. Sea buckthorns is a  Inhibit macrophages apoptosis. very beautiful, golden and orange berry, the roots of sea buckthorn trees go down 200 feet deep into the ground. It B. Punarnava : contains plenty of bioactive compounds along with Common name: Punarnava essential lipids, folic acid, phenols, flavonoids,tonnins and Scientific name: Boe rharia diffusa plethora of viral minerals. Sea buckthorn contains Clade :Tracheophytes numerous essential fatty acid including omega 3,6 & 9 rich Clade: Angiosperms source of omega 7 fatty acid. Rare and vital components Clade: Eudicots from plant source. It contains lipid and water soluble Kingdom: Plantae vitamin like A,E,B1,B2,B6,C etc. along with several amino Division: Magnoliophyta acids. Class: Magnoliopsida Order: Caryophyllales  It has following properties: Family: Nyetaginaceae  Anti-diabetic Genus: Boerhavia  Anti- hypertension Species: B.diffusa  Anti-oxidant

Fig 2

IJISRT20JUN294 www.ijisrt.com 254 Volume 5, Issue 6, June – 2020 International Journal of Innovative Science and Research Technology ISSN No:-2456-2165 In Ayurveda punarnava has major health benefits. It  Immunomodulator including management of diabetes. the extracts of its leaves  Rejuvenator control the glucose levels and enhances levels of plasma insulin, which are essential for diabetes. The herb also C. Karela: helps control obesity. a major risk factor for diabetes. It Common name: Karela regulate the blood sugar level of the body. The production Scientific name: Momordica charantia of insulin from the B pancreatic cells becomes active while Clade: Tracheophytes taking this herb. It considered as a rejuvenator. It helps to Clade: Angiosperms reduce breakdown of starch into glucose which in turn Clade: eudicots prevents the spike in blood sugar. Clade: Plantae Division: Magnoliopsida  It has following properties: Class:Magnoliopsida  Anti-diabetic Order :Cucurbitales  Anti oxidant Family :Cucurbitaceae Genus: Momordica Species M.charantia

Fig 3

Karela has been used in Asian and African herbal D. Jamun: medicine. The karela has been used in traditional medicine Common name : Jamun of India. There are different parts of plant are used for Scientific name: Syzygium cumini treatment of diabetes. It is also used for treatment on skin Clade: Tracheophytes disease, wounds, fever, cancer prevention.It is beneficial in Clade: Angiosperms karela increases cellular uptake of glucose. It improves the Clade: Rosids glycemic control. Kingdom: Plantae Division: Magnoliophyta  It has following properties: Class:Magnoliopsida  It is diabetes management. Order: Myrtales  Regulate blood flow Family: Myrtaceae  Hair health Genus: Syzygium  Anti - cancer Species: S.cumini  Anti- ageing  Skin infection

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Fig 4

Jamun is a highly effective fruit .The jamun has been E. Bael: used on treatment of diabetes . The seed of the fruit have Common name: Bael various active compound. It is used to slow down the rate Scientific name: Aegle marmelos of sugar released into the blood and increase the insulin Clade: Rosids level in the body . It has reduced the symptoms of diabetes Clade: Angiosperms like frequent urination & thrusting .It is a sugar lowering Clade: Tracheophytes agent . It helps for the management of diabetes. It is Kingdom: Plantae described in Ayurveda for its benefit’s in diabetes. Division: Magnoliophyta Class: Magnoliopsida  It has following properties: Order: Sapinaales  Anti - diabetic agent Family: Rutaceae  Anti - hyperglycemic agent Genus: Aegle  Hepatoprotective Species: A.marmelos  Prevent liver damage

Fig 5

IJISRT20JUN294 www.ijisrt.com 256 Volume 5, Issue 6, June – 2020 International Journal of Innovative Science and Research Technology ISSN No:-2456-2165 Bael leaf is used to the treatment on diabetes .It helps F. Neem: lowering blood glucose level. Bael leaf poses Common name: Neem antihyperglycemic activity. It has helps in lowering blood Scientific name: Azadirachta glucose level in streptozotocin induced in the diabetic rats Clade: Eudicots (STZ- S). It poses a Antidiabetic activity, Antioxidant Clade: Rosids activity, Anti- inflammatory . Clade: Tracheophytes Kingdom: Plantae  It has following properties: Division: Magnoliophyta  Antidiabetic Class: Magnoliopsida  Antioxidant Order: Spindales  Antipyretic Genus: Azadirachta  Hepatoprotective effect Species: A.indica  Anti- bacterial activity

Fig 6

Neem is commonly known as Azadirachta indica. It is G. Aloe Vera: the most important medicinal part of Ayurveda. Neem Common name: Aloe vera contain the antibacterial property. It help manage blood Scientific name: Aloe barbadensis Miller sugar level. It has regulate their blood sugar level .The bark Clade: Tracheophytes seeds and leaves are used to make medicines .Neem is not Clade: Angiosperms Only used in diabetes but also cure the asthma & alcer Clade: Monocots Kingdom: Plantae  It has following properties: Division: Magnoliophyta  Antidiabetic Class: Liliposida  Antibacterial Order: Asparagales  Antioxidant Family: Asphodelaceae  Antiinflammatory Genus: Aloe  control diabetes Species - A.vera  Helps the cure leprosy.

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Fig 7

Aloe Vera is commonly known as Aloe barbadensis  Then add into above juice. Miller .It stimulates the secretion of insulin. Aloe Vera is  Now mix the above mixture uniformly. useful for the people who are suffering from diabetes .It  Add 2 gm of Aloe Vera powder used as preservative maintaining the blood sugar level. Generally Aloe Vera is and mix it. use as preventive. such as Aloe Vera as powder soluble in  Make up the volume with distilled water. water which act as a preservative.  Transfer into the suitable container and store in a cool and dark place.  It has following properties:  Antidiabetic IV. RESULT /DISCUSSION  Antioxidant  Antibiotic With the help of present study formulation of herbal sea  Preservative agent buckthorn diabo juice is prepared for the treatment of diabetes . Diabetes is major health problem in today's era.  Material used as: This herbal formulation does not show any side effect. It is  sea buckthorn juice very effective against diabetes.  Karela extract  Jamun extract V. CONCLUSION  Punarnava extract  Bael extract This medicinal juice have antidiabetic property hence  Neem extract this herbal product stimulate the B - pancreatic cells hence  Aloe Vera powder result in the production of insulin in the body helps to  Distilled water maintain the blood sugar level .The herbal product of sea  Beakers buckthorn diabo juice does not have any side effect.  Measuring cylinder  Weighing balance REFERENCES  Stirrer [1]. Textbook of pharmacognosy by Dr. Kuntal Das, 1 st III. EXPERIMENTAL METHODOLOGY edition January 2019 [2]. http://www.anbg.gov.au/cgi-bin/apni?taxon_id=38551  Clean all the apparatus and glasswares. [3]. Tongliao Medicinal Factory 1992. A new  Take a beaker. seabuckthorn medicine product.  Weigh accurate 70 ml of sea buckthorn juice & add into [4]. https://npgsweb.ars- the breaker. grin.gov/gringlobal/taxonomydetail.aspx?id=311403  Measure the accurately 5% of Punarnava extract and [5]. Li Yong et al. 1989. Blocking and preventing actions add into above juice. of seabuckthorn juice from sintering NEMA  Weigh accurate 5% of Karela and Jamun extract then and inducing white rat's cancer in vivo. J. Nutrition 1 add into above beaker. (1) : 47-49  Also measure the 5% of Bael extract and 3% Neem extract respectively.

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