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Association ofRacing Commissioners International, Inc. Testing Standards and Practices Program Model Rules Guidelines

Uniform Classification Guidelines for Foreign Substances and Recommended Penalties and Model Rule

Version 10.00 Revised July 2015 Association of Racing Commissioners International, Inc. Uniform Classification Guidelines for Foreign Substances

Table of Contents

Preamble to the Uniform Classification Guidelines ofForeign Substances ...... iii Notes Regarding Classification Guidelines ...... iii Class1. fication . Cr1ter1a ...... 1v. Classification Definitions ...... :...... v Drug Classification Scheme ...... vii Alphabetical Substance List ...... 1 Listing by Classification ...... 13 Non-Classified Substances ...... 27 Recommended Penalty and Model Rule ...... 28 Recent Document Revisions ...... 32

Association ofRacing Commissioners International, Inc. Page i Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Association ofRacing Commissioners International, Inc. Page ii Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Preamble to the Uniform Classification Guidelines of Foreign Substances

The Preamble to the Uniform Classification Guidelines was approved by the RCI Drug Testing and Quality Assurance Program Committee (now the Drug Testing Standards and Practices Program Committee) on August 26, 1991. Minor revisions to the Preamble were made by the Drug Classification subcommittee (now the Veterinary Pharmacologists Subcommittee) on September 3, 1991.

"The Uniform Classification Guidelines printed on the following pages are intended to assist stewards, hearing officers and racing commissioners in evaluating the seriousness of alleged violations ofmedication and prohibited substance rules in racing jurisdictions. Practicing equine veterinarians, state veterinarians, and equine pharmacologists are available and should be consulted to explain the pharmacological effects ofthe listed in each class prior to any decisions with respect to penalities to be imposed. The ranking of drugs is based on their pharmacology, their ability to influence the outcome ofa race, whether or not they have legitimate therapeutic uses in the racing horse, or other evidence that they may be used improperly. · These classes of drugs are intended only as guidelines and should be employed only to assist persons adjudicating facts and opinions in understanding the seriousness of the alleged offenses. The facts of each case are always different and there may be mitigating circumstances which should always be considered. These drug classifications will be reviewed frequently and new drugs will be added when appropriate."

Notes Regarding Classification Guidelines

• Where the use of a drug is specifically permitted by a jurisdiction, then the jurisdiction's rule supersedes these penalty guidelines.

• Regulators should be aware that a laboratory report may identify a drug only by the name of its metabolite. The metabolite might not be listed here, but the parent compound maybe.

• These classes of drugs are intended only as guidelines and should be employed only to assist persons adjudicating facts and opinions in understanding the seriousness of the alleged offenses. ·

• The facts of each case are different and there may be mitigating circumstances that should be considered.

• These drug classifications will be reviewed periodically. New drugs will be added or some drugs may be reclassified when appropriate.

• Found substances or drugs not included in these guidelines should be treated as Class 1 violations warranting a Class A penalty unless otherwise advised by consultation · with Racing Commissioners International (RCI) and/or the Racing and Testing Consortium (RMTC).

Association ofRacing Commissioners International, Inc. Page iii Uniform Classification Guidelines for Foreign Substances

Version 10.00 ~ Revised July2015 Classification Criteria

The RCI Drug Classification Scheme is based on 1) pharmacology, 2) drug use patterns, and 3) the appropriateness of a drug for use in the racing horse. Categorization is decided using the following general guidelines:

• Pharmacology. Drugs that are known to be potent or are placed in higher classes, while those that have ( or would be expected to have) little effect on the outcome ofa race are placed in lower classes.

• Drug Use Patterns. Some consideration is given to placement of drugs based on practical experience with their use and the nature of positive tests. For example, positives have in the past been associated primarily with the administration of procaine , and this has been taken into consideration in the placement of procaine into Class 3 instead ofClass 2 with other injectable local .

• Appropriateness ofDrug Use. Drugs that clearly are intendep. for use in equine therapeutics are placed in lower classes. Drugs that clearly are not intended for use in the horse are placed in higher classes, particularly ifthey might affect the .outcome of a race. Drugs that are recognized as legitimately useful in equine therapeutics but could affect the outcome of a race are placed in the middle or higher classes.

The list includes most drugs that have been reported as detected by racing authority laboratories in the United States, Canada, the United Kingdom and other Association of Official Racing Chemists (AORC) laboratories, but does not include those which would seem to have no effect on the performance of the horse or drug detectability. For example, it does not include antibiotics, sulfonamides, vitamins, anthelmintics, or pangamic , all ofwhich have been reported.

The list contains many drugs that have never been reported as detected. Usually, these are representatives of chemical classes that have the potential for producing an effect, and in many cases, for which at least one drug in that chemical class has been reported.

Most drugs have numerous effects, and each was judged on an individual basis. There are instances where there is a rather fine distinction between drugs in one category and those in the next. This is a reflection ofa nearly continuous spectrum of effects from the most innocuous drug on the list to the drug that is the most offensive. ·

Association ofRacing Commissioners International, Inc. Page iv Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July2015 Classification Definitions

• Class 1: and drugs that have the highest potential to affect performance and that have no generally accepted medical use in the racing horse. Many of these agents are Drug Enforcement Agency (DEA) schedule II substances. These include the following drugs and their metabolites: Opiates, opium derivatives, synthetic and psychoactive drugs, and -like drugs as well as related drugs, including but not limited to , , , , and . Though ·not used as therapeutic agents, all DEA Schedule 1 agents are included in Class 1 because they are potent stimulant or depressant substances with psychotropic and often habituative actions.

• Class 2: Drugs that have a high potential to affect performance, but less ofa potential than drugs in Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse. Drugs in this class include: psychotropic drugs, certain nervous system and cardiovascular system stimulants, depressants, and neuromuscular blocking agents. Injectable local anesthetics are included in this class because of their high potential for abuse as nerve blocking agents.

• Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology of which suggests less potential to affect performance than drugs in Class 2. Drugs in this class include bronchodil~tors, anabolic steroids and other drugs with primary effects on· the autonomic nervous system, procaine, with properties and the high-ceiling diuretics.

• Class 4: This class includes therapeutic that would be expected to have less potential to affect performance than those in Class 3. Drugs in this class includes less potent diuretics; corticosteroids; antihistamines and skeletal muscle relaxants without prominent central nervous system (CNS) effects; expectorants and mucolytics; hemostatics; cardiac glycosides and anti-arrhytbmics; topical anesthetics; antidiarrheals and mild analgesics. This class also includes the non-steroidal anti-inflammatory drugs (NSAIDs), at concentrations greater than established limits.

• Class 5: This class includes those therapeutic medications for which concentration limits have been established by the racing jurisdictions as well as certain miscellaneous agents and other medications as determined by the regulatory bodies. Included specifically are agents that have very localized actions only, such as anti-ulcer drugs, and certain anti-allergic drugs. The drugs are also included.

Association ofRacing Commissioners International, Inc. Pagev Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July2015 • Prohibited Practices: A) The possession and/or use of a drug, substance or medication, specified below, on the premises of a facility under the jurisdiction of the regulatory body for which a recognized analytical method has not been developed to detect and confirm the administration of such substance; or the use of which may endanger the health and welfare ofthe horse or endanger the safety ofthe rider or driver; or the use ofwhich may adversely affect the integrity ofracing:

1) Erythropoietin 2) Darbepoietin 3) Oxyglobin 4) Hemopure

B) The possession and/or use of a drug, substance, or medication on the premises of a facility under the jurisdiction ofthe regulatory body that has not been approved by the United States Food and Drug Administration (FDA) for use in the United States.

C) The practice, administration, or application of a treatment, procedure, therapy or method identified below, which is performed on the premises of a facility under jurisdiction of a regulatory body and which may endanger the health and welfare ofthe horse or endanger the safety ofthe rider or driver, or the use ofwhich may adversely affect the integrity of racing:

Association ofRacing Commissioners International, Inc. Page vi Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July2015 .Drug Classification Scheme

• Class 1: Opiates, opium derivatives, synthetic opioids, psychoactive drugs, amphetamines, and all DEA Schedule I substances (see http://wv.'W.deadiversion.usdoj.gov/schedules/#list), and many DEA Schedule II drugs. Also found in this class are drugs that are potent stimulants of the CNS. Drugs in this class have no generally accepted medical use in the racing horse and their pharmacologic potential for altering the performance ofa racing horse is very high.

• Class 2: Drugs placed in this category have a high potential for affecting the outcome ofa race. Most are not generally accepted as therapeutic agents in the racing horse. Many are products intended to alter consciousness or the psychic state ofhumans, and have no approved or indicated use in the horse. Some, such as injectable local anesthetics, have legitimate use in equine medicine, but should not be found in a racing horse. The following groups ofdrugs are placed in this class:

A. Opiat~ partial , or -antagonists. B. Non-opiate psychotropic drugs. These drugs may have stimulant, depressant, analgesic or neuroleptic effects. C. Miscellaneous drugs, which might have a stimulant effect on the CNS. D. Drugs with prominent CNS depressant action. E. Anti-depressant and drugs, with or without prominent CNS stimulatory or depressant effects. F. Muscle blocking drugs - those that have a direct neuromuscular blocking action. G. Local anesthetics that have a reasonable potential for use as nerve-blocking agents ( except procaine). H. Snake venoms and other biologic substances that may be used as nerve-blocking agents.

• Class 3: Drugs placed in this class may or may not have an accepted therapeutic use in the horse. Many are drugs that affect the cardiovascular, pulmonary and autonomic nervous systems. They all have the potential of affecting the performance of a racing horse. The following groups of drugs are placed in this class:

A. Drugs affecting the autonomic nervous system that do not have prominent CNS effects, but which do have prominent cardiovascular or respiratory system effects. Bronchodilators are included in this class. B. A local that has nerve-blocking potential but also has a high potential for producing urine residue levels from a method ofuse not related to the anesthetic effect ofthe drug (procaine). C. Miscellaneous drugs with mild sedative action, such as the sleep-inducing antihistamines. D. Primary vasodilating/hypotensive agents. E. Potent diuretics affecting renal :function and body fluid composition. F. Anabolic and/or androgenic steroids and other drugs.

Association ofRacing Commissioners International, Inc. Page vii Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July2015 • Class 4: Drugs in this category comprise primarily therapeutic medications routinely used in racehorses. These may influence performance, but generally have a more limited ability to do so. Groups of drugs assigned to this category include the following:

A. Non-opiate drugs that have a mild central antipyretic effect. B. Drugs affecting the autonomic nervous system that do not have prominent CNS, cardiovascular, or respiratory effects: 1. Drugs used solely as topical vasoconstrictors or decongestants. 2. Drugs used as gastrointestinal antispasmodics. 3. Drugs used to void the urinary bladder. 4. Drugs with a major effect on CNS vasculature or smopth muscle ofvisceral organs. C. Antihistamines that do not have a significant CNS depressant effect. This does not include the H2 blocking agents, which are in Class 5. D. Mineralocorticoid drugs. E. Skeletal muscle relaxants. F. Anti-inflammatory drugs. These drugs may reduce pain as a consequence oftheir anti-inflammatory action. 1. Non-steroidal anti-inflammatory drugs (NSAIDs). (-like drugs). 2. Corticosteroids (glucocorticoids). 3. Miscellaneous anti-inflammatory agents. G. Less potent diuretics. H. Cardiac glycosides and antiarrhythmic agents. 1. · Cardiac .glycosides. 2. Antiarrhythmic. agents (exclusive oflidocaine, , and ). 3. Miscellaneous cardiotonic drugs. I. Topical Anesthetics - agents not available in injectable formulations. J. Antidiarrheal drugs. K. Miscellaneous drugs: 1. Expectorants with little or no other pharmacologic action. 2. Stomachics. 3. Mucolytic agents.

• Class 5: Drugs in this category are therapeutic medications for which concentration limits have been established by the racing jurisdictions as well as certain miscellaneous agents. Included specifically are agents that have very localized actions only, such as anti-ulcer drugs, and certain antiallergic drugs. The anticoagulant drugs are also included.

Association ofRacing Commissioners International, Inc. Page viii Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July2015 Recommended Penalty and Model Rule (Continued)

The following are recommended penalties for violations due to the presence of a drug carrying a Category "C" penalty and overages for permitted NSAIDs and : (All concentrations are for measurements in serum or plasma.)

.··•·· 10· .t"'' '· tr;::.2·0·£5iijt ''•.•'"I"l)1..:(,. ;t!Y..•~,,~9i9:f,,\i .•• ... ~ ,':~Ag l)l . (•'•>, 1 ''Fl •-"•· 't>'20' l00 ""gl .J) .··.. •' ·' ' : ··•. ,, '\• ,, ·.< : :: >,:: :, >;:::c ii~ ~1:!•;:>:: " }i',:i:,:·:s;,•;} ~D~~:l~1,;'?L >...... ,i•~)~· ,' ··.·:,; .. ••.:••~lCENSED ..'.IJlA:INER ii. . •.,,., , : '",. ., . , , .:,.,,,,ii.'•,•i1:1,,:. Ketop11!)f~11.: C~.50 mg/ml): , ,i-Yffitt1t·. 1 6 teto 'H5fen:i~50i'nitirll)and::S:;'\+t ·.•···:•···•·•;;:, ··••:·•t,·,·. ,··:::J[;~i~t:r ·~:Ili:j};ii.;;'lii{;f ~111ijI\~ :·,1~:t1~!~!1~~:i~~l~l?r!lmf~i!&iifr~~d ii~r~~~~t1~}~1!l~t~~f{JJ'.]t~:1[fi,} · · 1st Offense (365-day period) in any Minimum of a written warning to maximum fme of Minimum fine of$1,000 absent mitigating circumstances jurisdiction $500

2nd Offense (365-day period) in any Minimum of a written warning to maximum fine of Minimum fme of$1,500 and 15-day suspension absent mitigating. jurisdiction $750 circumstances

3rd Offense (365-day period) in any Minimum fine of$500 to a maximum fine of$1,000 Minimum fine of$2,500 and 30-day suspension absent mitigating jurisdiction circumstances .·

1st Offense (365-day period) in any ~'~ll~fHorse may be requiredlJlil~~~w;1~1A•"''' to pass commission-approved Loss ofpurse. Horse must pass commission-approved examination jurisdiction examination before being eligible to run before being eligible to run

2i:td Offense (365-day period) in any Horse may be required to pass commission-approved Loss ofpurse. Ifsame horse, placed on veterinarian's list for 45 jurisdiction examination before being eligible to run days, must pass commission-approved examination before being eligible to run

3rd Offense (365-day period) in any Disqualification and loss ofpurse. Horse must pass Loss ofpurse. Minimum $5,000 fine. Ifsame horse, placed on jurisdiction commission-approved examination before being eligible veterinarian's list for 60 days, must pass commission-approved to run· examination before being eligible to run

*Ifthe trainer has not had more than one violation within the previous two years, the Stewards/Judges are encouraged to issue a warning in lieu of a fine provided the reported level is below 3.0 mcg/ml absent of aggravating factors.

After a two-year period, ifthe licensee has had no further violations, any penalty due to an overage in the 2.0-5.0 category will be expunged from the licensee's record for penalty purposes.

Association of Racing Commissioners International, Inc. Page 29 Uniform Classification Guidelines for Foreign Substances

Version 9.00 - Revised April 2015 Alphabetical Substance List

Drug Penally Drug/Substance Trade Name(s) Class Class Amisometradine I Rolictron I Solian 2 A Mitaban Acenocoumarol 5 C Amitriotvline Elavil, Amitril, Endeo 2 A Atrovet, Notensil, Ammivin, Norvasc 4 B 3 B PromAce® Amytal 2 A Acetaminophen () Tylenol, Tempra, etc. 4 C Asendin 2 A Acetanilid 4 B Amoerozide 2 A Diamox, Vetamox 4 B Amohetamine 1 A Tindal 2 A Amrinone 4 B Acetophenetidin () 4 B Amyl nitrite 3 A Acetylsalicylic acid (Aspirin) 4 C Leritine 1 A Alclomethasone Aclovate 4 C Anilopam Anisine 2 A 2 A Anisindione 5 C monosemicarbazone Anisotropine Valpin 4 B 4 B salicylate Antipyrine 4 B Albuterol () Proventil, Ventolin 3 B Apazone (Az.apropazone) Rheumox 4 B 2 A Aoomorohine 1 A Alcuronium Alloferin 2 A Aorindine 4 B Aldosterone Aldocortin, Electrocortin 4 B Alurate 2 A Alfenta 1 A 3 A Axert 3 A 3 A Alphaprodine Nisentil 2 A Septocaine; Ultracaine, etc. 2 A Anaxyl 2 A Tenormin 3 B Xanax 2 A Strattera 2 A 3 A Atracurium Tracrium 2 A Althesin Saffan 2 A 3 B Ambenonium Mytelase,Mveuran 3 B Azacylonol Frenque 2 A Ambroxol Ambril, etc. 4 C Stresnil, Suicalm, Fentaz Amcinonide Cyclocort 4 C 2 A (with ) Moduretic; Midamor 4 B Lioresal 4 B Aminocaoroic acid Amicar, Caprocid 4 C Veronal 2 A 4 B 2 A Tuamine 4 B Beclomethasone Propaderm 4 C Aminophyllin, etc. 3 B Megimide, Mikedimide 2 A 4 B Benazeprilat, Benazepril and MC-tab Lotrel, Lotensin 3 A Aminoxafen, Bendroflumethiazide Naturetin 4 B I Aminoxaphen, Apiquel, 1 A Benoxaorofen 2 A McN-742, Menocil

Association ofRacing Commissioners International, Inc. Page 1 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont)

Drug Penalty ') I . Class Class '4 C B utabarbital (Secbutobarbitone) Butacaps, Butasol, etc. 2 A 2 A Butyn 4 B 2 A () Fiorinal 2 A Benzactizine Deprol, Bronchodiletten 2 A (butyl aminobenzoate) Butesin 4 C 4 B B utanilicaine Hostacain 2 A 2 A Repoise 2 A 2 A Butoctamide Listomin 2 A Tessalon, Tessalon Perles, Butorphanol Stadol, Torbugesic 3 B Benzonatate 2 A Zonatuss Butoxycaine Stadacain 4 B Benzohetamine Didrex 2 A N-Butylscopolamine 3 B Benzthiazide 4 B 2 B 2 A Calusterone Methosorb 3 B (BZP) I A Paxor 2 A 4 B Camphor 4 C Betamethasone Betasone, etc. 4 C Candesartan Atcand 3 B Kerlone 3 B Covatine 2 A Urecholine, Duvoid 4 C Caotopril Capolen 3 B Bethanidine Esbatal 3 A Carbacel, Conducton 3 A Akineton 3 A Lentin, Daryl 3 B Biriperone 2 A Carbamezapine Tegretol 3 B Zebeta, Bisobloc, etc. 3 B Carbazochrome 4 C Effectin 3 A Carbidopa + levodopa Sinemet 2 A Bolasterone 3 A Clistin 3 B Boldenone Equipoise 3 B Carbromol Mifudonn 2 A Boldione 3 A Carfentanil I A Bretylium Bretylol 3 B Carisoorodol Rela, Soma 2 B Alphagan 2 A Carphenazine Proketazine 2 A Lexotan, Lectopam 2 A Prazinii 2 A Duract 3 A Carorofen Rimadyl 4 B Bromhexine Oletor, etc. 4 B Cartrol 3 B Bromisovalum Diffilcord, etc. 2 A Carticaine (see articaine) · Septocaine; Ultracaine, etc. 2 A Parlodel 2 A Coreg 3 B 3 B khat, kat, qat, quat, chat, Bromidol 2 A catha, Abyssinian tea, I 1 I A Dimetane, Disomer 4 B African tea Brotocol 2 A Celebrex 3 B Budesonide Pulmacort, Rhinocort 4 C Zyrtec 4 B 3 A betaine Beta-Chlor 2 A Bumex 3 B Nactec, Oridrate, etc. 2 A Marcaine 2 A Chloraldehvde (chloral) 2 A Temgesic 2 A (Alpha-Chloralose) 2 A Wellbutrin 2 A Librium 2 A Buspar 2 A Chlorhexidol 2 A

Association ofRacing Commissioners International, Inc. Page2 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont)

Drug Penalty Drug/Subslance Trade Name(s) Class Class Tranxene Trancopal 2 A Clormecaine Placacid 4 2 A Clostebol 3 Chlorophenesin Maolate 4 C Clothiapine Entermin 2 B Nesacaine 2 A Trecalmo, Rfae 2 A Chloroquine Avloclor 4 C Enadel, Sepazon, Tolestan 2 A Chlorothiazide Diuril 4 B Clozaril, Leponex 2 A Chloroheniramine Chlortriemton, etc. 4 B Cobalt 3 Bl Newiolege 2 A a- I A Chlororomazine Thorazine, Largactil 2 A I B Taractan 2 A Codeine I A Chlorthalidone Hydroton 4 B Colchicine 4 B Paraflex 4 B Conorohone 2 A Ciclesonide 4 B Corticaine U!tracain 2 A Cilostazol Pletal 5 C Cortisone Cortone, etc. 4 C Cimeterol 3 A Cromolyn lntel 5 C Tagamet 5 D Crotetamide 2 A Nupercaine 4 C Tercian 2 A Citalooram Celex 2 A Cyclandelate Cyclospasmol 3 A Clanobutin 4 B Cyc!izine Merazine 4 B Tavist 3 B Phanodorm 2 A Ventioulmin 3 B Cyclobenzaorine Flexeril 4 B Clibucaine Batrax 4 C Cyclomethylcaine Surfacaine 4 C Clidinium Quarezan, Clindex, etc. 3 B Anhydron,Renazide 4 B Urbany! 2 A Cycrimine Pagitane 3 B Clobetasol Temovate 4 C Periactin 4 C 2 A Danazol Danocrine 3 B Clocortolone Cloderm 4 C Dantrolene Dantrium 4 C Clofenamide 4 B Darbepoetin Aranesp 2 A (Chlormethiazole) 2 A Svncurine 2 A Anafranil 2 A Dehydrochloromethyltestosterone · 3 B 2 A Dembroxol (Dembrexine) Sputolysin 4 C 3 B 2 A

· 1 For cobalt concentrations ofless than 25 parts per billion (ppb) ofblood serum or plasma no penalty is recommended. For concentrations of25 ppb or greater but less than 50 ppb ofblood plasma or serum the recommended penalty is a written warning, the placement ofthe horse on the Veterinarians List with_ removal from list only after a test confirms that the concentration is below 25 ppb ofblood plasma or serum. Testing shall be paid by the owner(s) ofthe horse. Concentrations of50 ppb or greater in blood plasma or serum have a recommended "B" penalty.

Association ofRacing Commissioners International, Inc. Page3 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont) Drug Penalty Drug/Substance Trade Name(s) Class Class Percortin, DOCA, D1soovram10° Ncirpace 4 B Deoxycorticosterone 4 C Desc_2tone, Dorcostrin Divalproex Depakote 3 A Deremaxx 3 B Esucos 2 A Dermorphin A Dobutrex 3 B Desioramine Norpromine,_Pertofrane 2 A Intropin 2 A Desonite Des Owen 4 C DoneQezil AriceQt A Desoximetasone Topicort 4 C Doxacurium Nuromax 2 A Desoxymethyltestosterone 3 B Doxapram Dooram 2 A Dormosedan 3 B 3 A Dexamethasone Azium, etc. 4 C Doxans 2 A 4 B Doxep_in Adaoin, Sineg_uan 2 A Dextromoramide Palfium, 1'Jar_i:olo A Doxvlamine Deca 3 B Darvon 3 B Dromostanolone Drolban 3 B Dezocine Dalgan 2 A Inapsine, Droleptan, A Innovar-Vet (with 2 A 2 B Fentanvl 3 B 2 A Dibucaine Nupercainal,_ Cinchocaine 4 C Dyclone 4 C Febenol, Isocom 2 A 3 B Dichlorphenamide Daramide 4 C Tensilon 3 B Voltaren, Voltarol 4 C Relpax 3 A Dicumarol Dicumarol 5 C 4 C Dieth_l'.!propion Teoanil, etc. 2 A metabolite enaloprilat Vasotec 3 B Themalon 2 A 2 A Diflorasone Florone, Maxiflor 4 C A Diflucortolone Flu-Cortinest, etc. 4 C A 3 B 2 A Dicitoxin Crystodicin 4 B Eoibatidine 2 A Digoxin Lanoxin 4 B Epinephrine 2 A Dih_l'.drocodeine Parcodin 2 A mesylates 4 ( dihydroergocornine mesylate, B 2 A Dilorazepam Briantum 2 A dihydroergocristine mesylate, and Cardizem 4 B mesylate) Dimefline 3 A Ergonovine Ergotrate 4 C _Quotane 4 B Gvnergen, Cafergot, e_!_c. 4 B Domoso 4 C Cardilate 3 A 5 C Epogen, Procrit, etc. 2 A 5 C Brevibloc 3 B Bena 3 B Nexium 5 D Domnamid, Eurodin, Difenoxin, Lomotil 4 B 2 A M50/50 2 A Nuctalon Persantine 3 B 3 B Novin, Methampyrone 4 C Enbrel 4 B

Association ofRacing Commissioners International, Inc. Page4 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont)

Ethacrynic acid Edecrin 3 B 3 B Ethamivan 2 A Flumethasone Flucort, etc. 4 C 2 A Flumethiazide Ademol 4 B Placidvl 2 A Sibelium 4 B Valmid 2 A Flunisolide BroniHd_e, etc. 4 C Ethoheptazine Zactane 4 B Rohypnol, Narcozep, 2 A Ethopropazine Parsidol 2 A Darkene, Hypnodorm Zarontin 3 A Banamine 4 C* Peganone 4 B Fluocinolone Synalar 4 C Car_cjr~se, Ethamide 4 C Fluocinonide 4 C Ethylaminobenzoate (Benzocain~ Semets, etc. 4 C Fluopromazine 2 A Ethvlestrenol Maxibolin, Organon 3 B Fluoresone 2 A Ethvlisobutrazine Diauel 2 A Fluorometholone 4 B Ethylmorphine Dionin A Fluoroprednisolone Predef-2X 4 C Ethvlnorepinephrine Bronkephrine 3 A Prozac 2 A Duranest 2 A Fluoxymesterone Halotestin 3 B Etifoxin Stresam 2 A Flupenthixol Deoixol, Fluanxol 2 A Deoas, Pasaden 2 A Prolixin. Permitil, 2 A Lodine 3 B Anatensol, etc. Indunox 2 A Katadolone 3 A .2 A Fluprednisolone Alohadrol 4 C Etorphine HCl M99 A Flurandrenolide Cordran 4 C Famoticline Gaster, etc. 5 D Dalmane 2 A Felbatol 3 A Froben 3 B Felodioine Plendil 4 B Imap, Redeotin 2 A Fenarbamate T 2 A Fluticasone Flixo11~§C:,_ Flutide 4 C 3 B Restas 2 A 2 A Fluvoxamine Dum_irox, Faverin. etc. 2 A F enfluramine Pondimin 2 A Formebolone 3 B Corlopam 3 B Altram 3 B Nalfon 3 B F osinop_ril Monopril 3 A Berotec 3 B Fosphenvtoin Cereb 3 B Respiride, Respan. etc 3 B Furazabol 3 B Sublimaze A Furosemide Lasix NIA 3 B Neurontin 4 B Allegra 4 C Reminyl 2 A 4 C Gallamine Flaxedil 2 A Idalon 4 B Gamma Aminobufrvic Acid (GABA) Carolina Gold 3 B Idalon, Idarac 4 B 2 A Sedalande 2 A Gestrinone 3 A Flucinolone 4 C Doriden 2 A 2 A Glycopyrrolate Robinul 3 B Fludrocortisone Alforone, etc. 4 C

Association ofRacing Commissioners International, Inc. Page 5 .Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont) Drug Penalty Drug/Substance Trade Name(s) Class Class (glycerol guiacolate) Geeolate · 4 C Darbid I B Guanadrel Hylorel 3 A Isoproterenol Isoorel 2 A Ismelin 3 A Isosorbide dinitrate Isordil 3 B Wvtensin 3 B Maxicam 2 Halazeoam Paxioam 2 A Isoxsuorine Vasodilan 4 Halcinonide Halog 4 C DynaCirc 4 Halobetasol Ultravate 4 C 3 Halooeridol Haldol 2 A Ketalar, Ketaset, Vetalar 2 B Somelin 2 A Anxon, Laftram, Solatran, 2 A Hemo12:lobin 12:lutamers Oxvo-lobin Hemooure 2 A Loftran Corofundol 3 B Orudis 4 C* Heroin 1 A Toradol 3 A Hexafluorenium Mvalexen 2 A Normodvne 3 B Evioal 2 A Lamictal 3 A Hexocvclium Tral 4 C Lansoorazole 5 D Cyclaine 4 C Elanone-V 2 A Homatrooine Homapin 3 B Letosteine Viscotiol, Visiotal 4 C Homoohenazine Pelvichthol 2 A 2 B Hvdralazine Aoresoline 3 B Beta12:an 3 B H vdrochlorthiazide Hvdrodiuril 4 B 2 A Hvcodan 1 A Levo-Dremoran 1 A Cortef, etc. 4 C Xylocaine 2 B Saluron 4 B Lisinopril Prinivii, Zestril 3 A Dilaudid 1 A Lithizi.ne, Duralith, etc. 2 A Paradrine 1 A 2 A 3 B Lofentanil 1 A Atarax 2 B Loflazepate, Ethyl Victan 2 A Noctal 2 A Imodium 2 A Motrin, Advil, Nuroin, etc. 4 C Dormonort, Havlane 2 A Corvert 3 B Loratidine Claritin 4 B Ventavis 3 A Ativan 2 A Imavate, Presamine, Noctamid 2 A 2 A Tofranil Losartan Hyzaar 3 B Indomethacin Indocin 3 B Loxaoine Laxitane 2 A Infliximab Remicade 4 B 3 A Ipratropium 3 B Ludiomil 2 A Irbesarten Avapro 3 A Mazindol Sanorex 1 A Isaoirone 2 A Axiten, Dormate, Caola 2 A Isocarboxazid Marolan 2 A Inversine 3 B Isoetharine Bronkosol 3 B Meclizi.ne Antivert, Bonine 4 B Isofluoredone Predef 4 C Arauel 4 C Isomethadone 2 A Lucidiril, etc. 2 A Isometheotene Octin, Octon 4 B Medazeoam Nobrium, etc. 2 A

Association ofRacing Commissioners International, Inc. Page 6 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont)

Drug Penalty ) Class Class Domitor 3 B Methasterone 3 A Medrvsone Medriusar, etc. 4 C Methazolamide Naptazane 4 C Ponstel 3 B 1 A Mobic 4 B Tacaryl 4 B Euneroan 2 A Methixene Trest 3 A Namenda 2 A Robaxin 4 C Oblivon 2 A Brevital 2 A Pacatal 2 A Methotrexate Folex, Nexate, etc. 4 B Cantil 3 A Methotrimeprazine Levoprome, Neurocil, etc. 2 A Demerol I A Vasoxyl 3 A Tolserol 4 B Orthoxide 3 A Control, etc. 2 A Methscopolamine Pamine 4 B Wyamine 1 A Methsuximide Celontin 3 A Mesantoin 2 A 3 B Mephobarbital Methvlchlorthiazide Enduron 4 B Mebaral 2 A (Methyl ) Methyldienolone 3 B Carbocaine 2 B Methvldooa Aldomet 3 A Equanil, Miltown 2 A Geranamine 1 A Meralluride Mercuhvdrin 4 B (Methylhexaneamine) Novasural 4 B Methylergonovine Methercine 4 C Thiomerin 4 B Methylnortestosterone 3 B Cumertilin 4 B Ritalin 1 A Salyrgan 4 B Methylprednisolone Medrol 4 C Mesalamine Asacol 5 C Methyl Metandren 3 A Serentil 2 A Methyl-I-testosterone 3 A Mestanolone 3 B Noludar 2 A Mesterolone 3 B Sansert 4 B Talis 2 A 4 B Metaproterenol Alupent, Metaprel 3 B Reglan 4 C Aramine 1 A Metubine 2 A Skelaxin 4 B Metolazone 3 B Metazocine 2 A Hypnodil 2 A Metenolone 3 B Metopon 1 A Methachloline 3 A (methydihydromorphinone) Dolophlne I A Lopressor 3 B Desoxyn I A Melex 2 A Methandienone 3 B Mexilitine Mexilil 4 B Methandriol Probolic 3 B Posicor 3 B Methandrostenolone Dianabol 3 A Mibolerone 3 B Banthlne 3 B Versed 2 A Methaovrilene Histadyl, etc. 4 B Pro-Amiline 3 B Quaalude 1 A Milrinone 4 B Gemonil 2 A Loniten 3 B

Association ofRacing Commissioners International, Inc. Page7 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont) Drug Penalty Drug/Substance Trade Name(s) Class Class I Norbolethone I Norclostebol Mivacurium Mivacron 2 A Nordiazepam Calmdav, Nordaz, etc. 2 --A Provigil 2 A N orepinephrine 2 A Moexipril (metabolite, moexiprilat) Uniretic 3 B N orethandrolone 3 A Mohan 2 A N ortestosterone 4 C Mom etas one Elocon 4 C N ortriptvline A ventvl, Pamelor 2 A Montelukast Simrulair 4 C Nylidrine Arlidin 3 A Luvati-en 2 A Olanzepine Zyprexa 2 A 1 B Olmesartan Benicar 3 A 2 A Olsalazine Dipentum 4 B 3 A Omeprazole Prilosec, Losee 5 D mvo-Inositol Trispvrophosphate (ITPP) 1 A Norlfex 4 B Anthraxan, Relafen, Oxabolone 3 B 3 A Reliflex Oxandrolone Anavar 3 B Nadal Corgard 3 B Daypro, Deflam 4 C Amvlsine 4 C Oxazeoam Serax 2 A Nubain 2 A Serenal 2 A Nalline, Lethidrone 2 A Trileptal 3 A Naloxone Narcan 3 A (hydroxyephedrine) 2 A Naltrexone Revia 3 A Trasicor 3 B Nandrolin, Laurabolin, Percodan 1 A Nandrolone 3 B Durabolin Oxymesterone 3 B Privine 4 B Afrin 4 B Equiproxen, Naprosvn 4 C Oxvmetholone Adrovd, Anadrol 3 B Naratriotan Amerge 3 B Oxvmorphone Numorphan 1 A 3 A Oxyperitine F orit, Integrin 2 A Nedocromil Tilade 5 C Tandearil 4 C Serzone 2 A Daricon 4 B 3 A Oxyphenonium Antrenyl 4 B Prostigrnine 3 B 2 A Cardine 4 B Pancuronium Pavulon 2 A Procardia 4 B Pantoprazole Protonix 5 D l Nifluril 3 B Papaverine Pavagen, etc. 3 A Niketharnide I Coramine 1 A Paral 2 A 3 B Paradione 3 A Erimin 2 A Paramethasone Haldrone 4 C Nemotop 4 B Pargyline Eutonvl 3 A Magadan 2 A Paxil, Seroxat 2 A 3 B Pemoline Cylert 1 A Axid 5 C Levatol 3 B 19-Norandrostenediol 3 B Cyperon 2 A 19-Norandrostenedione 3 B Pentaervthritol tetranitrate Duotrate 3 A

Association ofRacing Commissioners International, Inc. Page 8 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont)

Penalty Drug/Substance Trade Name(s) Class Talwin 3 B E'1peroua Metycaine ~ Nembutal 2 A Lonseren, Piportil 2 Trental, Vazofirin .4 C 'ipradrol !)__ataril, Gerondyl, etc. 2 Metrazol, Nioric A 'iguindone 2 ~ I Taxilan 2 A Maxair 3 A 2 A PirenzaQine GastrozeQin 5 C 2 A Arelix, Tauliz 3 B 2 A Piritramide A 2 A Feldene 3 B Perfluorocarbons 2 A Polvethvlene glycol 5 C Per_g_olide Permax 3 B Polythiazide Renese 4 B Alodeot, etc. 2 A Pramoxine Tronothaine 4 C Biorel 3 A Verstran, Centrax 2 A Perlaoine Hvonodin 2 A Minipress 3 B Perohenazine Trilafon 2 A Prednisolone Delta-Cortef,_ etc. .4 C Phenurone 4 B Prednisone Meticorten, etc. 4 C Phenae:lvcodol Acalo, Alcamid, etc. 2 A Citanest 2 C Phenazocine Narphen A Mvsoline 3 B (PCP Semvlan A Probenecid 4 C Bontril, etc. A Pronestvl 4 B N ardelzine, N ardil 2 A Procaine 3 B Phenindione Hedulin 5 C Pro Air 3 A Preludin A Prochloroerazine Darbazine, Compazine 2 A 2 A Kemadrin 3 B Phenoxvbenzamine line 3 B 3 B 5 C 3 B 4 B 4 B Iomamin 2 A 2 A Regitine 3 B Pro-Banthine 3 A 4 C* Ophthaine 4 C Isophrin, Neo- 3 B Karsivan 3 B Prooadrine 3 B Largon 2 A Dilantin 4 B Tranvet 2 A ine Eserine 3 B 2 A A Diprivan,_Disoprivan 2 A Alvodine, Cimadon 2 A Ravocaine 2 A Ora· 2 A Inderal 3 B Damar 2 A Benzedrex 4 B Viskin 3 A 3 B Dipiperon 2 A Domina! 2 A Arduan 2 A Ventaire 3 A Pi 2 A Protriotvline Concordin, Triptil 2 A Pi Psymod, Quide 2 A Axeen, Centralgo[ 2 A

Association ofRacing Commissioners International, Inc. Page 9 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont) Drug Pena Drug/Substance Tr Drug/Substance Trade Name(s) Class Cla I I Cenafed, 2 A aosng ine I Mestinon,~ Regonol I 3 B Spirapril, metabolite Spiraprilat Renomax 3 A 3 B Spironalactone Aldactone 4 B I 2 A Stanozolol Winstrol-V 3 B Quazipam Doral 2 A Stenbolone 3 B Seroquel 2 A 1 B Quinbolone 3 B Succinylcholine Sucostrin, Quelin, etc. 2 A )uinaoril, Quinaprilat Accupril 3 A Sufenta 1 A Quinidex, Ouinicardine 4 B Sulfasalazine Azulfidine, Azaline 4 C Rabeprazole Aciphex 5 D Sulfondiethylmethane 2 A Racemethorphan 2 A 2 A 2 A Inofal 2 A 2 A Clinoril 3 A Paylean 2 A Aiglonyl, Sulpitil 2 A Ramipril, metabolite Ramiprilat Altace 3 A Barnetil 2 A Zantac 5 D hnitrex 3 B Rernifentanil Ultiva 1 A Synthetic Spice, K2, Kronic 1 A Remoxioride Roxiam 2 A Tadalasil Cialis 3 A Seroasil 2 A Talbutal Lotusate 2 A 2 A Tandosoirone 2 A Risoeridone 2 A Telmisartin Micardis 3 B 2 A Restoril 2 A Yutopar 3 B Al Qfillex, etc. 3 B Rivastie:mine Exelon 3 B 3 B Maxalt 3 B Hytrin 3 A Rocuronium Zernuron 2 A Brethine, Bricanvl 3 B Vioxx 2 A Seldane, Triludan 4 B Rornifidihe Sedivet 2 B Testolactone Teslac ' 3 B Naropin 2 A Testosterone 3 B 4 C Nitoman 2 A 4 C Pontocaine 2 A 3 B Tetrahydrogestrinone 3 A Triptone 3 B Tetrahydrozoline Tyzine 4 B Seconal 2 A Musaril, Myolastin 2 A Eldepryl, Jumex, etc. 2 A Thebaine 2 A Sertraline Lustral, Zolo:ft 2 A 4 B Meridia 3 B Aqualphyllin, etc. 3 B Sildena:61 Viagra 3 A Kemithal 2 A Snake Venoms 2 A Thiamvlal Surita! 2 A Somatropin Nutropin 2 A Torecan 2 A Somatrem Protropin 2 A Thiopental Pentothal 2 A Betapace, Sotacor 3 B Dartal 2 A Spiclomazine 2 A Majeptil 2 A

Association ofRacing Commissioners International, Inc. Page 10 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont) Drug Penalty Drug/Substance Trade Name(s) Class Class Mellaril 2 A pron 4 Thiosalicylate 4 C I Tubocurarine } Metubin 2 A Thiothlxene Navarre 2 A D~ Benvil, Nospan, etc. 2 A Thiphenamil Trocinate 4 B Urethane 2 A Italprid, Luxoben,.etc. 2 A 2 A Surgam 3 B V alerenic acid 3 A Component ofTelazol 2 A V alnoctamide Nirvany] 2 A Tolopelon 2 A Valsartan Diovan 3 B Blocardrin 3 B Vardenafil Levitra 3 A Tonocard 4 B Vedaprofen 4 B Grandaxain, Seriel 2 A Efflexor 2 A Prisco line 3 B Acciona!, Veralioril 2 A Tolectin 3 B Calan, Isoptin 4 B Tooirimate Tooamax 2 A Vercuronium Norcuron 2 A Torsemide (Torasemide) Demadex 3 A C~t_atrol,_yivalan, etc. 2 A Ultram 2 A Delvinol 2 A Trandolapril (and metabolite, Optanox,_Speda 2 A Tarka 3 B trandolaorilat) Cournadin, Coufarin 5 C Tranexarnic acid 4 C Xvlazine Rompun, Bay Va 1470 3 B Tranvlcvoromine Parnate 2 A Xvlometazoline Otrivin 4 B Desyrel 2 A 2 A Trenbolone Finoplix 3 B Zafirlukast Accolate 4 C Inolin 2 A Sonata 2 A Triamcinolone Vetalog, etc. 4 C Zeranol Ralgro 4 C Dyreniurn 4 B 1 A Halcion 2 A Zileuton ZY110 4 C Tribromethanol 2 A h}'drochloride Zilpaterol 2 A Tricaine methanesulfonate Finquel 2 A Geoden 2 A Trichlormethiazide Naqua, Naquasone 4 C 2 A Trichloroethanol 2 A Zomi 3 B Tricholoethylene Trilene, Trimar 2 A Ambien_,_Stilnox 2 A Triclos 2 A Zomax 2 A Pathilon 4 B 3 B Trifluomeprazine Nortran 2 A 2 A Stelazine 2 A 2 A Triperidol 2 A · 2 A Vetame, Vesprin 2 A 6.-1-androstene-3, 17-diol 3 A Trihexyl phenidyl Artane 3 A 6.-1-andr·ostege--3_,_17-di one 3 A Temaril 4 B 6.-1- 3 A Tridione 3 B Trimethaphan Arfonad 3 A *See Recommended Penalty Section ofDocument Surmontil 2 A PBZ 3 B

Association ofRacing Commissioners International, Inc. Page 11 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Alphabetical Substance List (Cont)

Association ofRacing Commissioners International, Inc. Page 12 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification Class 1: Stimulant and depressant drugs that have the highest potential to affect performance and that have no generally accepted medical use in the racing horse. Many ofthese agents are Drug Enforcement Agency (DEA) Schedule II substances. These ,include the following drugs and their metabolites: Opiates, opium derivatives, synthetic opioids, psychoactive drugs, all DEA Schedule 1* substances (see http://vvww.usdoj.gov/dea/pubs/scheduling.html), amphetamines and amphetamine-like drugs as well as related drugs, including but not limited to apomorphine, nikethamide, mazindol, pemoline, and pentylenetetrazol.

Mazindol Sanorex A Meperidine Demerol A Aminoxafen, Wyamine A Aminorex Aminoxaphen, Apiquel, 1 A Metaraminol Aramine A McN-742, 1'1eri_~ Methadone Dolophine A Amphetamine A Desox A Anileridine Leritine A Quaalude A A Methcathinone A A Methylhexanamine Geranamine A A (Methylhexaneamine) khat, kat, qat, quat, chat, Methylphenidate Ritalin A Cathinone catha, Abyssinian tea, A 1 A African tea a-Cobratoxin A B Cocaine 1 B Myo-inositol trisphrophosphate 1 A Codeine A ITPP DEA Schedule 1 (all)"'_ A Nikethamide Coramine A A Ox_ycodone Percodan A Palfium, Narc()_!_()_ A Oxymorphone A A Pemoline A Done_p_ezil Aricept A Pentylenetetrazol A Endorphins A Phenazocine A Enkephalins l A Phenc_yclidine (PCP A Dionin A Phendimetrazine A M99 A 1 A Fentan_yl Sublimaze A 1 A A Piritramide A Hydocane 1 A Ultiva A Dilaudid A Strychnine B Paradrine A Sufentanil Sufenta A Levo-Dremoran A Synthetic cannabis Spice, K.2, Kronic A Lofentanil A Ziconotide A

Association ofRacing Commissioners International, Inc. Page 13 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 2: Drugs that have a high potential to affect performance, but less ofa potential than Class 1. These drugs are 1) not generally accepted as therapeutic agents :in racing horses, or 2) they are therapeutic agents that have a high potential for abuse.

Drug Penalty Trade Name(s) Class Class Acecarbromal 2 A Bromazepam · Lexotan, Lectopam Acetophenazine Tindal 2 A Bromisovalum Diffucord, etc. IJ Adinazolam 2 A Parlodel 2 Alclofenac 2 A Bromidol 2 A Alloferin 2 A Brotocol 2 A Nisentil 2 A Buoivacaine Marcaine 2 A Anaxvl 2 A Buorenorohine Temgesic 2 A Xanax 2 A Busoirone Buspar 2 A Althesin Saffan 2 A Buorooion Wellbutrin 2 A Amisulpride Solian 2 A (Secbutobarbitone) Butacaos, Butasol, etc. 2 A Amitriotvline Elavil, Amitril, Endep 2 A Butalbital (Talbutal) Fiorinal 2 A Amobarbital Amvtal 2 A Butanilicaine Hostacain 2 A Asendin 2 A Butaoerazine Reooise 2 A 2 A Butoctamide Listomin 2 A Anisine 2 A Caffeine 2 B Aorobarbital Alurate 2 A Camazepam Paxor 2 A Septocaine; Ultracaine, Captodiame Covatine 2 A Articaine 2 A etc. Carbidopa + levodopa Sinemet 2 A Atomoxetine Strattera 2 A Carbromol Mifudorm 2 A Atracurium Tracrium 2 A Soma, Rela 2 B Azacylonol Frenque 2. A Carphenazine Proketazine 2 A Stresnil, Suicalm, Fentaz Carpioramine Prazinil 2 A Azaperone 2 A (with Fentanyl) Septocaine; Ultracaine, Carticaine (see articaine) 2 A Barbital Verona! 2 A etc. 2 A Chloralose (Alpha-Chloralose) 2 A Megimide, Mikedim1de 1 - 2 A Beta-Chlor 2 A 2 A Chloral hydrate Nactec, Oridrate, etc. 2 A Anquil 2 A Chloraldehyde (chloral) 2 A Tiadipona 2 A Chlordiazepoxide Librium 2 A Benzactizine Deprol, Bronchodiletten 2 A Chlormezanone Trancopal 2 A Benzoctamine 2 A Chloroform 2 A Benzodiazepines 2 A Chlorhexidol 2 A Tessalon, Tessalon Chloroprocaine Nesacaine 2 A Benzonatate 2 A Perles, Zonatuss Chlorproethazine Newiplege 2 A Didrex 2 A Thorazine, Largactil 2 A Cogentin 2 A Chlorprothixene Taractan 2 A 2 A Citalooram Celex 2 A Brimonidine 2 A C!obazam Urbany! 2 A

Association ofRacing Commissioners International, Inc. Page 14 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 2: Drugs that have a high potential to affect performance, but less ofa potential than Class I. These drugs are I) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse.

Drug Penalty Drug/Substance Trade Name(s) Class Class I I Chlonnethiazole moan'"" C Anafranil 2 A E ine hrine I I 2 Klonooin 2 A Ergoloid Mesylates = Clorazepate Tranxene 2 A ( dihydroergocomine Mesylate, dihydroergocristine mesylate Entennin 2 A 2 A and dihydroergocryptine mesylate I I Trecalmo, Rize 2 A IHydergine Enadel, Sepazon, Cloxazolam 2 A Tolestan Clozaoine Clozaril, Leoonex 2 A Ervthroooietin (EPO) Eoogen, Procrit, etc. 2 A Domnamid, Eurodin, Conorohone 2 A Estazolam 2 A Corticaine Ultracain 2 A Nuctalon Crotetamide 2 A Ethamivan 2 A Cyamemazine Tercian 2 A Ethanol 2 A Cvclobarbital Phanodonn 2 A Ethchlorvvnol Placidvl 2 A Darbeooetin Araneso 2 A Ethinamate Valmid 2 A Decamethonium Syncurine 2 A Ethoorooazine Parsidol 2 A Demoxeoam 2 A Ethylisobutrazine Diquel 2 A Norpromine, Pertofrane 2 A Etidocaine Duranest 2 A Dezocine Da!gan® 2 A Etifoxin Stresam 2 A Valium 2 B Etizolam Depas, Pasaden. 2 A Dichloralohenazone Febenol, Isocom 2 A Etodroxizine Indunox 2 A Diethylorooion Teoanil, etc. 2 A Etomidate 2 A Diethylthiambutene Themalon 2 A Fenarbamate Tymium 2 A Dihvdrocodeine Parcodin 2 A Fenclozic Acid Cincopal 2 A Briantum 2 A F enfluramine Pondimin 2 A M50/50 2 A Fluanisone Sedalande 2 A Esucos 2 A Fludiazeoam Erispam 2 A Intropin 2 A Rohypnol, Narcozep, Darkene, Hypnodonn Doxacurium Nuromax 2 A Flunitrazepam Doxapram Dopram 2 A I 2 I A Doxefazepam Doxans 2 A Darkene, Hypnodonn Adapin, Sineauan 2 A Darkene, Hypnodonn Darkene Inapsine, Droleptan, Fl uooromazine Psvauil, Simril 2 Droperidol I Innovar-Vet (with 2 A A Fentanvl) Fluoresone Caducid 2 A Duloxetine I 2 A Fluoxetine Prozac 2 A Enciorazine 2 A Flupenthixol Depixol, Fluanxol 2 A

Association ofRacing Commissioners International, Inc. Page 15 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 2: Drugs that have a high potential to affect performance, but less ofa potential than Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse.

Drug Penally Drug/Substance Trade Name(s) Class Class Lidocaine Xylocaine Fluphenazine · I Prolixin, Permitil, 2 A I Anatensol, etc. Lithium Lithizine, Duralith, etc. 2 Dalmane 2 A Lobeline 2 ~ Imap, Redeptin 2 A Loflazepate, Ethyl Victan 2 A Restas 2 A Loperamide Imodium · 2 A Fluvoxamine Dumirox, Faverin, etc. 2 A Loprazolam Dormonort, Havlane 2 A Galantamine Reminvl 2 A Lorazepam Ativan 2 A Gallamine Flaxedil 2 A Lormetazepam Noctamid 2 A Gepirone 2 A Laxitane 2 A Glutethimide Doriden 2 A Maorotiline Ludiomil 2 A Halazeoam Paxipam 2 A Mebutamate Axiten, Dormate, Capla 2 A Haldol 2 A Meclofenoxate Lucidiril, etc. 2 A Haloxazolam Somelin 2 A Nobrium, etc. 2 A Hemoglobin glutamers Oxyglobin, Hemopure 2 A Eunerpan 2 A 2 A Namenda 2 A 2 A Meparfvnol Oblivon 2 A Homophenazine Pelvichthol 2 A Mepazine Pacatal 2 A Atarax 2 B Control, etc. 2 A Thoma! Noctal 2 A Mephenytoin Mesantoin 2 A Imavate, Presamine, Mephobarbital

Association ofRacing Commissioners International, Inc. Page 16 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 2: Drugs that have a high potential to affect performance, but less ofa potential than Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse.

Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Namc(s) Class Class Class Class [ Luvatren [Pipecuronium I Arduan Mosaprimine I Pipegualine a10UP Nubain 2 A . Psvmod, Quide Nalorphine Nalline, Lethidrone 2 A Metycaine 2 A Nefazodone I Serzone 2 A Pipotiazine Lonseren, Piportil 2 A Erimin 2 A Pivradrol Dataril, Ger.ondyl, etc. 2 A Mogadon 2 A 2 A Calmday, N_ordaz, etc. 2 A Prazepam Verstran, Centrax 2 A 2 A Prilocaine Citanest 2 A 2 A Darbazine, Compazine 2 A 2 A 2 A Serax 2 A Largon 2 A Serenal I 2 A Propionylpromazine Tranvet 2 A 2 A Prooiram 2 A Forit,_ Igtegr_in l 2 A Prooofol Diorivan, Disoprivan 2 A 2 A Propoxvcaine Ravocaine 2 A Pancuronium Pavulon 2 A Prothipendvl Domina! 2 A Paraldehyde Paral 2 A Concordin, Triptil 2 A Paroxetine Paxil, Seroxat 2 A Proxibarbital Axeen, Centralgol 2 A Penfluridol Cyperon 2 A Pyrithyldione Hvbersulfan, Sonodor 2 A Nembutal 2 A Quazioam Doral 2 A Taxilan 2 A Quetiapine Seroquel 2 A Perfluorodecolin 2 A Racemethorphan 2 A Perfl uorodecahvdronoohthalene 2 A Racemorphan 2 A 2 A Raclopride 2 A Perfluorotripropylamine 2 A Ractopamine Paylean 2 A Perfl uorocarbons I 2 A Roxiam 2 A Alodept, etc. 2 A Reserpine Serpasil 2 A Hvonodin 2 A Rilmazafone 2 A Trilafon 2 A 2 A Acalo, Alcamid, etc. 2 A Ritanserin 2 A Phenelzine Nardelzine, Nardil 2 A Rivas tie.mine Exelon 2 A Phenobarbital Luminal 2 A Rocuronium Zemuron 2 A Phentermine Iomamin 2 A Rofecoxib Vioxx 2 A Piminodine Alvodine, Cimadon 2 A Sedivet 2 B Pimozide Orap 2 A Rooi vacaine Narooin 2 A Pinazepam Damar 2 A (Quinalbarbitone) Seconal 2 A Dioioeron 2 A Eldepryl, Jumex - - 2 A

Association ofRacing Commissioners International, Inc. Page 17 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 2: Drugs that have a high potential to affect performance, but less ofa potential than Class I. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse.

Drug Penalty Drug/Substance Trade Name(s) ·.~:_., Class Class Tricaine methanesulfonate Finguel I Snake Venoms Trichloroethanol Somatrem Protropin 2 A Tricholoethylene Trilene, Trimar 2 Somatropin Nutropin 2 A Triclofos Triclos 2 A Spiclomazine 2 A Trifluomeprazine Nortran 2 A Spiperone 2 A Trifluoperazine Stelazine 2 A Succinylcholine Sucostrin, Quelin, etc. 2 A Trifluoeridol Trioeridol 2 A Sulfondiethvlmethane 2 A Triflupromazine Vetame, Vesprin 2 A Sulfonmethane 2 A Surmontil 2 A Jnofal 2 A Tubocurarine (Curare) Metubin 2 A Aiglonyl, Sulpitil 2 A Tvbamate Benvil, Nospan, etc. 2 A Barnetil 2 A Urethane 2 A Lotusate 2 A Valdecoxib 2 A 2 A Nirvanyl 2 A Temazepam Restoril 2 A V enlafaxine Efflexor 2 A Tetrabenazine Nitoman 2 A V eralipride Acciona!, Veralipril 2 A Tetracaine Pontocaine 2 A Vercuronium Norcuron 2 A Tetrazepam Musaril, Myolastin 2 A Viloxazine Catatrol, Vivalan, etc. 2 A Thebaine 2 A Vinbarbital Delvinol 2 A Thialbarbital Kemithal 2 A Vinylbital Optanox, Speda 2 A Surita! 2 A Yohimbine 2 A Thiethylperazine Torecan 2 A Zaleplon Sonata 2 A Thiopental Pentothal 2 A Zilpaterol hydrochloride Zilpaterol 2 A Dartal 2 A Ziprasidone Geodon 2 A Majeptil 2 A Zolazepam 2 A Thioridazine Mellaril 2 A Ambien, Stilnox 2 A Thiothixene I Navane 2 A Zomax 2 A Italprid, Luxoben, etc. 2 A Imovan 2 A Component ofTelazol 2 A Zotepine Lodopin 2 A Tolopelon 2 A Zuclopenthixol Ciatyl, Cesordinol 2 A Grandaxain, Serie! 2 A Topirimate Topamax 2· A Tramadol Ultram 2 A Tranvlcvoromine Parnate 2 A Trazodone Desyrel 2 A Tretoauinol Inolin 2 A Triazolam Halcion 2 A Tribromethanol 2 A

Association of Racing Commissioners International, Inc. Page 18 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classificatio_n (Continued) Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology ofwhich suggests less potential to affect performance than drugs in Class 2.

Drng Penalty Drng/Substance Trade.Name(s) Class Class Bufexamac I Atrovet, Notensil, Bumetanide Bumex Acepromazine 3 B PromAce® Butornhanol Stadol, Torbugesic Albuterol (Salbutamol) Proventil, Ventolin 3 B N-Butvlscooolamine 3 B Almotriptan Axert 3 A Cal usterone 3 B Alorenolol 3 A Candesartan Atacand 3 B Ambenonium Mvtelase,Mveuran 3 B Caotooril Capolen 3 B Aminoohvlline Aminophyllin, etc. 3 B Carazolol Carbacel, Conducton 3 A Amitraz Mitaban 3 A Carbachol Lentin, Dorvl 3 B Amlodipine Norvasc 3 A Carbamezapine Tegretol 3 B Amyl nitrite 3 A Carbinoxamine Clistin 3 B Arecoline 3 A Carteolol Cartrol 3 B Arformoterol 3 A Carvedilol Coreg 3 B Atenolol Tenormin 3 B Celecoxib Celebrex 3 B Atropine 3 B Cimeterol 3 A Benazeprilat, Benazepril and MC-Tab Lotensin 3 A Clemastine Tavist 3 B Betaxolol Kerlone 3 B Clenbuterol Ventipulmin 3 B Bethanidine Esbatal 3 A Clidinium Quarezan, Clindex, etc. 3 B Akineton 3 A Cioni dine Catapres 3 B Bisoprolol Zebeta, Bisobloc, etc. 3 B Clostebol 3 B Bitolterol Effectin 3 A Cobalt 3 B2 Bolasterone 3 A Cyclandelate Cyclospasmol 3 A Boldenone Equipoise 3 B Cycrimine Pagitane 3 B Boldione 3 A Danazol Danocrine 3 B Bretylium Bretylol 3 B Dehydrochloromethyl testosterone 3 B Brimonidine Alphagan 3 B Deracoxib Deremaxx 3 B Bromfenac Duract 3 A Desoxvmethyltestosterone 3 B Bromodiphenhydramine 3 B Detomidine Dormosedan 3 B

2 For cobalt concentrations ofless than 25 parts per billion (ppb) ofblood serum or plasma no penalty is recommended. For concentrations of25 ppb or greater but less than 50 ppb ofblood plasma or serum the recommended penalty is a written warning, the placement ofthe horse on the Veterinarians List with removal from list only after a blood test confirms that the concentration is below 25 ppb ofblood plasma or serum. Testing shall be paid by the owner(s) ofthe horse. Concentrations of50 ppb or greater in blood plasma or serum have a recommended "B" penalty.

Association ofRacing Commissioners International, Inc. Page 19 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology ofwhich suggests less · potential to affect performance than drugs in Class 2.

Furazabol 3 B Neurontin 3 B ic Acid (GABA) Carolina Gold 3 B 3 A Gestrinone 3 A Benadryl 3 B Glycopyrrolate Robinul 3 B Dipvridamole I Persantine 3 B Guanadrel Hylorel 3 A Depakote 3 A Guanethidine Ismelin 3 A Dobutrex 3 B Guanabenz Wytensin 3 B Doxazosin I 3 A Heptaminol Corofundol 3 B Decapryn 3 B Homapin 3 B Drolban 3 B Hvdralazine Apresoline 3 B 3 B 4-Hvdroxvtestosterone 3 B Tensilon 3 B Corvert 3 B Relpax 3 A Ventavis 3 A Enalapri[ (metabolite enaloprilat) Vasotec 3 B Indomethacin Indocin 3 B Ergoloid mesylates 3 B lpratropium 3 B Erthrityl tetranitrate Cardilate 3 A Irbesarten Avapro 3 A Esmolol Brevibloc 3 B Isoetharine Bronkosol 3 B Etamiphylline 3 B Isosorbide dinitrate Isordil 3 B Ethacrynic acid Edecrin 3 B Kebuzone 3 B Ethosuximide Zarontin 3 A Ketorolac Toradol 3 A Ethylestrenol Maxibolin, Organon 3 B Labetalol Normodyne 3 B Ethylnorepinephrine Bronkephrine 3 A Lamotrigine Lamictal 3 A Etodolac Lodine 3 B Levobunolol Betagan 3 B Felbamate Felbatol 3 A Lisinopril Prinivii, Zestril 3 A Fenbufen Cincopal 3 B Losartan Hyzaar 3 B Fenoldopam Corlopam 3 B Mabuterol 3 A Nalfon 3 B Mecamylamine Inversine 3 B Berotec 3 B Medetomidine Domitor 3 B Respiride, Respan, etc 3 B Mefenamic Acid Ponstel 3 B Fentiazac 3 B Cantil 3. A 'Froben 3 B Mestanolone 3 B Flufenarnic Acid 3 B Mesterolone 3 B Fluoxymesterone Halotestin 3 B Metaproterenol Alupent, Metaprel 3 B Flupirtine Katadolone 3 A Metenolone 3 B Formebolone 3 B Methachloline 3 A Formoterol Altram 3 B Methandienone 3 B Monopril 3 A Methandriol Probolic 3 B Cerebyx 3 B Methandrostenolone Dianabol 3 A -- Association ofRacing Commissioners International, Inc. Page 20 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology ofwhich suggests less potential to affect performance than drugs in Class 2.

Drug Penalty Drug/Substance Trade Name(s) Class Class I Arlidin -----·... I Nylidrine I Methasterone 3 A Olmesartan I Benicar Methixene Trest 3 A Oxabolone Methoxamine Vasoxyl 3 A Oxandrolone Anavar Methoxyphenamine Orthoxide 3 A Oxcarbazepine Trileptal Methsuximide Celontin 3 A Oxprenolol Trasicor 3 B Methylatropine 3 B Oxvmesterone 3 B Methyldienolone 3 B Oxvmetholone Adrovd, Anadrol 3 B Aldomet 3 A Papaverine Pavagen, etc. 3 A Methvlnortestosterone 3 B Paramethadione Paradione 3 A Methvltestosterone Metandren 3 A Pargyline Eutonyl 3 A Methvl-1-testosterone 3 A Penbutolol Levatol 3 B 3 B Pentaerythritol te1ranitrate Duotrate 3 A Metoprolol Lopressor 3 B Pentazocine Talwin 3 B Mibefradil Posicor 3 B Permax 3 B Mibolerone 3 B Perindopril Biprel 3 A Midodrine Pro-Amilfoe 3 B Dibenzvline 3 B Minoxidil Loniten 3 B Regitine 3 B Moexipril (metabolite, moexiprilat) Uniretic 3 B Phenvlephrine Isophrin, Neo-Svnephrine 3 B Muscarine 3 A Propadrine 3 B Anthraxan, Relafen, Physosti=ine Eserine 3 B Nabumetone 3 A Reliflex Pindolol Viskin 3 A Nadol Corgard 3 B Pirbuterol Maxair 3 A Naloxone Narcan 3 A Piretanide Arelix, Tauliz 3 B Naltrexone Revia 3 A Piroxicam Feldene 3 B Nandrolin, Laurabolin, Prazosin Minipress 3 B Nandrolone 3 B Durabolin Primidone Mvsoline 3 B Amerge 3 B Procaine 3 B Nebivolol 3 A Procaterol Pro Air 3 A 3 A Procyclidine Kemadrin 3 B 1ine Prosti=ine 3 B Sparine 3 B Niflumic Acid Nifluril 3 B Phenergan 3 B 3 B Propantheline Pro-Banthine 3 A Nitroglycerin 3 B Propentophylline Karsivan 3 B 19-Norandrostenediol 3 B Propranolol Inderal 3 B 19-Norandrostenedione 3 B Prostanazol 3 B Norbolethone 3 B Ventaire. 3 A Norclostebol 3 B Pseudoephedrine Cenafed, Novafed 3 B Norethandrolone 3 A Pyridostie:mine Mestinon, Regonol 3 B

Association ofRacing Commissioners International, Inc. Page 21 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology of which suggests less potential to affect performance than drugs in Class 2.

rug cna ty Drug/Substance Trade Name(s) Class Class Diovan V·------alsart~_ IJ Vardenafil 3 0 omoun. BavVaVa 14701470 I 3 B Zomig 3 B Ritodrine Yutopar 3 -B Zonegran 3 B Rizatriptan Maxalt 3 B t.-1-androstene-3, 17-diol 3 A 3 B Li.-1-androstene-3, 17-dione 3 A oscine Triptone 3 B t.-1-dihydrotestosterone 3 A Sibutramine Meridia 3 B Sildenafil Viagra 3 A Sotalol Betapace, Sotacor 3 B Spirapril, metabolite Spiraprilat Renomax 3 A Stanozolol Winstrol-V 3 B Stenbolone 3 B Sulindac Clinoril 3 A Sumatriptan Imitrex 3 B Tadalasil Cialis 3 A Telmisartin Micardis 3 B Tenoxicam Alganex, e_ts 3 B Tepoxalin 3 B Terazosin Hvtrin 3 A Terbutaline Brethine, Brican}'.l 3 B Testolactone Teslac 3 B Testosterone 3 B 3 A 3 B 3 B Timolol Blocardrin 3 B Tolazoline Priscoline 3 B Tolmetin Tolectin 3 B Torsemide (Torasemid~ Demadex 3 A Trandolapril (and metabolite, Tarka 3 B Trandolaprilat) Trenbolone Finoplix 3 B Trihexvlohenidvl Artane 3 A Tridione 3 B Arfonad 3 A Trip_elennamine PBZ 3 B 3 A

Association ofRacing Commissioners International, Inc. Page22 Uniform Classification Guidelines for F9reign Substances :

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3.

4 B Cetirizine Acetazolamide Diamox, Vetamox 4 B Chlormerodrin Acetophenetidin (Phenacetin) 4 B Chlorophenesin Acetvlsalicvlic acid (Asoirin) 4 C Chloroquine Avloclor 4 Alclomethasone Aclovate 4 C Chlorothiazide Diuril 4 B Adrenochrome monosemicarbazone Chloroheniramine Chlortriemton, etc. 4 B 4 B salicvlate Chlorthalidone Hvdroton 4 B Aldosterone Aldocortin, Electrocortin 4 B Chlorzoxazone Paraflex 4 B Ambroxol Ambril, etc. 4 C Ciclesonide 4 B Amcinonide Cyclocort 4 C Cinchocaine Nupercaine 4 C Amiloride Moduretic; Midamor 4 B Clanobutin 4 B Amicar, Caprocid 4 C Clibucaine Batrax 4 C Amiodarone 4 B Clobetasol Temovate 4 C 2-Aminoheptane Tuamine 4 B Clocortolone Cloderm 4 C Aminonvrine 4 B Clofenamide 4 B Amisometradine Rolictron 4 B Clormecaine Placacid 4 C Amlopidine Norvasc, Ammivin 4 B Colchicine 4 B Amrinone 4 B Cortisone Cortone, etc. 4 C Valpin 4 B Merazine 4 B 4 B Cyclobenzaorine Flexeril 4 B Rheumox I 4 B Cyclomethylcaine Surfacaine 4 C 4 B Cyclothiazide Anhydron, Renazide 4 B Lioresal 4 B Cyproheptadine Periactin .4 C Beclomethasone Prooaderm 4 C Dantrolene Dantrium 4 C Benazepril Lotrel 4 B Dembroxol (Dembrexine) Sputolysin 4 C Bendroflumethiazide Naturetin 4 B Percortin, DOCA, Deoxycorticosterone 4 C Benoxinate Dorsacaine 4 C Descotone, Dorcostrin Benzocaine 4 B Desonite Des Owen 4 C Benzthiazide 4 B Desoximetasone Topicort 4 C Beoridil Beoadin 4 B Dexamethasone Azium,etc. 4 C Betamethasone Betasone, etc. 4 C Dextromethorohan 4 B Bethanechol Urecholine, Duvoid 4 C Dibucaine Nuoercainal, Cinchocaine 4 C Bromhexine Oletor, etc. 4 B Dichlorphenamide Daramide 4 C Dimetane, Disomer 4 B Diclofenac Voltaren, Voltarol 4 C Budesonide Pulmacort, Rhinocort 4 B Diflorasone Florone, Maxiflor 4 C Butacaine Butyn 4 C Diflucortolone Flu-Cortinest, etc. 4 C Butamben (butyl aminobenzoate) Butesin 4 C Digitoxin Crystodigin 4 B Stadacain 4 B Digoxin Lanoxin 4 B 4 C Dihydroergotamine 4 B Carbazochrome l l 4 C Diltiazem Cardizem 4 B

Association ofRacing Commissioners International, Inc. Page 23 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3.

Drug Penalty Drug/Substance Trade Name(s) Class Class D1metmsoa Quotane 4 B Motrin, Advil, Nurpin, 4 C >imethylsulfoxide DMSO) I Domoso 4 C etc. ---- Difenoxin, Lomotil 4 B Infliximab Remicade 4 B Novin, Methampyrone 4 C Isoflupredone Predef 4 C ----.de Norpace 4 B Octin, Octon 4 B ---- Dvclone 4 C Isopropamide Darbid 4 B 4 C Isoxsuorine Vasodilan 4 C 4 C Isradioine DvnaCirc 4 B Ergotarnine Gynergen, Cafergot, etc. 4 B Ketoprofen Orudis 4 C* Etanercept Enbrel 4 B Letosteine Viscotiol, Visiotal 4 C I Ethoheptazine Zactane 4 B Loratidine Claritin 4 B Ethotoin Peganone 4 B Antivert, Bonine 4 B Ethoxzolamide Cardrase, Ethamide 4 C Meclofenamic acid Arquel 4 C Ethylaminobenzoate (Benzocaine) Semets, etc. 4 C Medrysone Medriusar, etc. 4 C Plendil 4 B Meloxicam Mabie 4 B Fexofenadine Allegra 4 C Tolserol 4 B Firocoxib 4 C Meralluride Mercuhvdrin 4 B Flecainide Idalon 4 B Merbaphen Novasural 4 B Floctafenine Idalon, Idarac 4 B Mercaptomerin Thiomerin 4 B Flucinolone Synalar, etc. 4 C Mercumalilin Cumertilin 4 B Fludrocortisone Alforone, etc. 4 C Mersalyl Salyrgan 4 B Flumethasone Flucort, etc. 4 C Metaxalone Skelaxin 4 B Flumethiazide Ademol 4 B Histadyl, etc. 4 B Flunarizine Sibelium 4 B Methazolamide Naptazane 4 C Flunisolide Bronilide, etc. 4 C Methdilazine Tacaryl 4 B Flunixin Banamine 4 C* Methocarbamol Robaxin 4 C Fluocinolone Synalar 4 C Methotrexate Folex, Nexate, etc. 4 B Fluocinonide Licon, Lidex 4 C Methscopolamine Pamine 4 B Fluorometholone FML 4 B Methylchlorthiazide Enduron 4 B Fluoroprednisolone Predef-2X 4 C Methylergonovine Methergine 4 C Fluprednisolone Alphadrol 4 C Methvlorednisolone Mediol 4 C Flurandrenolide Cordran 4 C Methysergide Sansert 4 B Fluticasone Flixonase, Flutide 4 C Metiamide 4 B Guaifenesin (glycerol e:uiacolate) Gecolate 4 C Metoclopramide Reglan 4 C Halcinonide Balog 4 C Mexilitine Mexilil 4 B Halobetasol Ultravate 4 C Milrinone 4 B Tral 4 B Mometasone Elocon 4 C Hexylcaine Cyclaine 4 C Montelukast SinQU!air 4. C H vdrochlorthiazide Hydrodiuril 4 B Naepaine Amvlsine 4 C Hydrocortisone (Cortisol) Cortef, etc. 4 C Naohazoline Privine 4 B Hvdroflumethiazide Saluron 4 B Naproxen Equiproxen, Naprosyn 4 C

Association ofRacing Commissioners International, Inc. Page24 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3.

Procardia Nemotop 4 C Tuamine Dipentum 4 B Vedaprofen 4 B Norlfex 4 B Calan, Isoptin 4 B Daypro, Deflam 4 C Xvlometazoline Otrivin 4 C etazoline Afrin 4 B Zafirlukast Accolate 4 C phenbutazone Tandearil 4 C Zeranol Ralgro 4 C phencvclimine Daricon 4 B Zileuton Zvflo 4 C phenonium Antrenyl 4 B Paramethasone Halclrone 4 C *See Recommended Penalty Section ofDocument Pentoxyfylline Trental, Vazofirin 4 C Phenacemide Phenurone 4 B Phensuximide Milontin 4 B 4 C* Dilantin 4 B Polythiazide Renese- 4 B Pramoxine Tronothaine 4 C Prednisolone Delta-Cortef, etc. 4 C Prednisone Meticorten, etc. 4 C Probenecid 4 C Pronestyl 4 B Rythmol 4 B Proparacaine Ophthaine 4 C Benzeclrex 4 B Quinidine Quinidex, Quinicardine 4 B 4 C Salicvlate 4 C Spironalactone Aldactone 4 B Sulfasalazine Azulfidine, Azaline 4 C Terfenadine Seldane, Triludan 4 B Tetrahydrozoline Tyzine 4 B Theobromine 4 B Thiosalicylate 4 C Thiphenamil Trocinate 4 B Tocainide Tonocard 4 B 4 C Triamcinolone Vetalog, etc. 4 C Triamterene Dvrenium 4 B Trichlormethiazide Naqua, Naquasone 4 C

Association ofRacing Commissioners International, Inc. Page 25 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Listing by Classification (Continued) Class 5: This class includes those therapeutic medications for which concentration limits have been established by the racing jurisdictions as well as ce!iain miscellaneous agents and other medications as determined by the regulatory bodies.

Acenocoumarol 5 C Anisindione 5 C Cilostazol Pletal 5 C Tagamet 5 D Intel 5 C Dicumarol 5 C SM 5 C 5 C Esomeprazole Nexium 5 D Gaster, etc. 5 D Lansoprazole 5 D Mesalamine Asacol 5 C Misoorostel Cvtotec 5 C Nedocromil Tilade 5 C Nizatidine Axid 5 C Omeprazole Prilosec, Losee 5 D Pantoprazole Protonix 5 D Hedulin 5 C Liquamar 5 C Gastrozepin 5 C 5 C Aciohex 5 C Ranitidine Zantac 5 D Warfarin Coumadin, Coufarin 5 C

Association ofRacing Commissioners futemational, fuc. Page 26 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Non-Classified Substances

Substances that are considered to have no effect on the physiology of a racing animal except to improve nutrition or treat or prevent infections or parasite infestations, are not classified. These Substances normally include antimicrobials,· anti parasitic drugs, and nutrients such as vitamins. Examples ·of such substances include the following:

Sulfonamides and trimethoprim Bufotenine 1. Note: Bufotenine is not commerically available in any form.

Antibiotics: 2. Note: Bufotenine is a metabolite ofS-methoxy-N-N Cephalosporins dimethyltryptamine, found in reed canary grass Chloramphenicol (and potentially other food source plants). It may Aminoglycosides be found Tetractckubes in the urine of horses eating this grass (and Nitrofurans potentially other plant foods), and has been Metronidazole reported as a positive finding. Findings of bufotenine in equine urine should not be considered for regulatory action. Anthelmintics: Benzimadaziles Antifungals Vitamins A,D,E,K,B vitamins Vitamin C

Association ofRacing Commissioners International, Inc. Page27 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Recommended Penalty and Model Rule

The following are recommended penalties for violations due to the presence of a drug carrying a Category "A" penalty and for violations of ARCI-011-015 and .ARCI-025-015: Prohibited Practices:

• Minimum one-year suspension absent mitigating • Minimum three-year suspension absent mitigating • Minimum five-year suspension absent mitigating circumstances. The presence ofaggravating factors circumstances. The presence of aggravating factors circumstances. The presence ofaggravating factors could be used to impose a maximum ofa three-year could be used to impose a maximum oflicense could be used to impose a maximum of license suspension revocation with no reapplication for a three-year revocation with no reapplication for a five-year period. period.

AND AND AND

• Minimum fine of$10,000 or 10% oftotal purse 1 • Minimum fine of$25,000 or 25% oftotal purse 1 • Minimum fine of$50,000 or 50% oftotal purse (greater ofthe two) absent mitigating circumstances. (greater ofthe two) absent mitigating circumstances. (greater ofthe two) abs_ent mitigating circumstances. The presence ofaggravating factors could be used The presence ofaggravating factors could be used to The preence of aggravating factors could be, used to to impose a maximum of$25,000 or 25% ofpurse impose a maximum of$50,000 or 50% purse impose a maximum of $100,000 or 100% purse (greater ofthe two). (greater ofthe two). (greater ofthe two).

AND AND AND • May be referred to the Commission for any further • May be referred to the Commission for any further • May be referred to the Commission for any further action deemed necessary by the Commission. action deemed necessary by the Commission. action deemed necessary by the~Commission. 1m~-'l'bD'&ftl\~<11m:------~U-~lll'l01W1~W'4Y~,.~~ rd st 2°d LIFETTh1E offense in owner's stable any 3 LIFETIME offense in owner's stable in any 1 Offense jurisdiction jurisdiction • Disqualification and loss ofpurse • Disqualification and loss ofpurse • Disqualification, loss ofpurse and $50,000 fine AND AND AND • Horse shall be placed on the Veterinarian's List for • Horse shall be placed on the Veterinarian's List for • Horse shall be placed on the Veterinarian's List for 90 days and must pass a commission-approved 120 days and must pass a commission-approved 180 days and must pass a commission-approved examination before becoming eligible to be entered. examination before becoming eligible to be entered. examination before becoming eligible to be entered. AND • Referral to the Commission with a recommendation ofa suspension-for a minimum of_90 days.

Association ofRacing Commissioners International, Inc. Page 28 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Recommended Penalty and Model Rule (Continued)

The following are recommended penalties for violations due to the presence of a drug carrying Category "B" penalty, for the presence of more than one NSAID in a plasma/serum sample, subject to the provisions set forth in ARCI-Ol l-020(E) and ARCI-025-020(E) and for violations ofthe established levels for total carbon dioxide:

151 Offense 2" d offense 365-da eriod in an ·urisdiction 3rd offense 365-da eriod in an ·urisdiction • Minimum 15-day suspension absent mitigating • Minimum 30-day suspension absent mitigating • Minimum 60-day suspension absent mitigating circumstances. The presence ofaggravating factors circumstances. The presence of aggravating factors circumstances. The presence ofaggravating factors could be used to impose a maximum of a 60-day could be used to impose a maximum of a 180-day could be used to impose a maximum ofa one-year suspension suspension suspension.

AND AND • Minimum fine of $500 absent mitigating • Minimum fine of$1,000 absent mitigating • Minimum fine of $2,500 absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence ofaggravating factors could be used to impose a maximum fine of$1,000. could be used to impose a maximum fine of$2,500. could be used to impose a maximum of$5,000 or 5% purse (greater ofthe two).

AND • May be referred to the Commission for any further action deemed necessary by the Commission. 0 ~~~~c•"7"c,:,::::,l~'.,,"i">[ ,1,:---,~~ I ~lt."'''-®l);"~•~:t,i;;..--,~ -~:J_ 1 "Wl""~J~T.;-;r W$-;~~!s.(~,mt.11,r~-~1T~~ ~~W .~!/'.:['!( ~;;-,.LJ~~:~,..,,i~~~:.~~=,::i."'~ \~:L.:~~k-~:~a""l~=ht,:~~~-~ftr~~"I~~~ ,1, ,~~\ f :' '~~,.-~ 2nd offense (365-day period) in owner's stable any 3rd offense (365-day period) in owner's stable in any st 1 Offense I jurisdiction jurisdiction • Disqualification and loss ofpurse [in the absence of • Disqualification and loss ofpurse [in the absence of • Disqualification, loss ofpurse, and in the absence of mitigating circumstances]* mitigating circumstances]* mitigating circumstances a $5,000 fine.* AND AND AND • Horse must pass a commission-approved • Horse must pass a commission-approved • Horse shall be placed on the Veterinarian's List for examination before becoming eligible to be entered. examination before becoming eligible to be entered. 45 days and must pass a commission-approved examination before becoming eligible to be entered.

*The RMTC recommendation called for loss ofpurse to happen in absence ofmitigating circumstances. The Joint Model Rules Committee has made loss ofpurse mandatory in their proposal.

Association ofRacing Commissioners International, Inc. Page 29 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Recommended Penalty and Model Rule (Continued)

The following are rec01mnended penalties for violations due to the presence of a drug carrying a Category "C" penalty and overages for permitted NSAIDs and furosemide: (All concentrations arefor measurements in serum or plasma.)

:,:~f:1rl.?u.J~~1~~2;~0~·.?:·'.•1.();-S'.gi:~~ij{iw)t·;•.·•.· . ,/.: :: "·· ···.• ;.;;a.'jf: ,;, ·1t ·. ·.ta...... :''.ii',.;:/,...>'·· Je'o'·,<;::;;".<. " ,.· ··· /f... <.,.;,,,,,:,.,,1 .... un1~n•~ "'· OOngi'.ml} .... , , . . ,,,,,,::,,:,,,~~y u.. :z:p~e,,(:>~. ,..mcglml) .~~ftlfiie\-2;;~;~it1fi!t ..·. , ,,, i: ::,:jW1!/i:'1ff~~t\fi~i::,:\ , .· , ,,.,,...... ,,G,.lQO,nglntl)..and/or,, .. ,, .. ,. , , .,,.. ,,, , '"':·r,,,.,,,,,,1,,,,,,,,,,,,,,K•.,wP ..,.....,, ,,(?51 1 , •.,ng{ful)and. . ·:'"! ·':'•ti" ':I r,1:,:·r~;;: ".' ,·· .,.,.,.. ,,, !!,,C,!/;,•''i·•··' ,,,,.,.• ,, 1,e:,,1,!""i•!J''•: .'" •.''e•··''"'\·:'' :,;:,', •i,' . ' '". ,,,,., :'s•.:'•·,'.'l•I, ::1,,1,·,:,1:,,' '<.'; : .""'':!"""''':: ,'' ,,, ' ·, '' '"!!''i' ,·,. ; :·,,,."';ii',' :' ''· ,}!q '!l;:t;(!Sem1de,,'.vyije11liden~ifiecf 1as:adniinistef~di'i,;;!>' ·,·.·.· ' '' ,;::, ti,, ,,; :,1i11::i:ifr1!1',1i,J'.'\:iCL~~,;~,iV:iolation:si•· ,, /) --•• -- ~, •. . _____,__1::_~---'---''' ••~ ,, 0 •, '••'• .: .. ,,•, •'• ,:•,: ,' ,---:•<,,;;: " c,,;~:c;~"1''J '' ','"•,::,,;'.r/,~•~• •' ,, 0 1.t_i:"-:0< ' i,:,''J,·~,'::,llA~":j 1st Offense (365-day period) in any Minimum ofa written warning to maximum fine of Minimum fine of $1,000 absent mitigating circumstances jurisdiction $500

2nd Offense (365-dayperiod) in any Minimum of a written warning to maximum fine of Minimum fine of$1,500 and 15-day suspension absent mitigating jurisdiction $750 circumstances

3rd Offense (365-day period) in any Minimum fine of$500 to a maximum fine of$1,000 Minimum fine of$2,500 and 30-day suspension absent mitigating jurisdiction circumstances

Ph~nt1~~t~zorie({~W.~5:0,mcg/ml)~{}il\ '!!1:'!,l!iJ,{!i1!:i\')\i,i':i; ' ' ,' ,1 I ' 'I I ,, ., Elwiixui '(:>z"O'ttoo'·,.,nu)''''''"·'C',···· ''.' ··Ct;:,:·,,::,',:c,/:,::,:, \::,'··· Phenylbufaione,(>5"0 . { ]\ ii: :, ;i,,,. '" , ... ' , D1::,1, , : ., ;:::,,::1::·I,:•,,,,,,,,,,'",,; . .. ' •. mcg ~1 "' . ,,,?,t(i 11 1 · :Ii,.: Ketoprofen ~>i~ 50·ng/ml) ' · ,, .;.,,:/)·)", , ., Flu:o:Xin (>100 ng/ml) ,':, " ):'iii°' •· i ' <,,;,,:,,.1'''\,'s:.'.,,, ,,,.·. ii;,,, I ,·' ,,i ,.,;: .. ,;,, ,, ':., :.. ··' ' ,·,, ·:/:}': ,:J,:::;iiif;:::S"'''?'·.' ' " ' ",~. 'I '. i " " ' ' I ',: 1 ·~:":,:: ' ,, ,,,,,',••·· .,,, · •...... ,,.,,",FuroseD11de",(!>,:;I00-,ng/.mJ}.ani:llor,·. .· ,',:'·,,,,,.,:,,,,: ,,,,·,::,,.1:1•"·,···•...,,.,.,.;. ~· • ,,, n;etopttofen (~Q,;:i1g/m1,,and· :•·.•,,'':"t·,, ,,,, ':"'~'"'' .....:,:,:,:,., 1 ·.·:• .. :·· .· ·...ii&;fu$~$¢fuld~'1r4;~1:~w~~#fi~~~~i:i~f!fu'r~1~~~f~i!::r:::::,::: t:r,·:::,::,:Ii.,:. ,.;L.,:Li;,;;i:~:~;,:::;:,~::ee~~~;;:~~~ ,~!~~~~~::i:'"2:~.~;;:~:;i;;~;,Iii~~;::~:;; .0:·;::::~Fr·i 1st Offense (365-day period) in any Horse may be required to pass commission-approved Loss ofpurse. Horse must pass commission-approved examination jurisdiction examination before being eligible to run before being eligible to run ·

2nd Offense (365-day period) in any Horse may be required to pass commission-approved Loss ofpurse. If same horse, placed on veterinarian's list for 45 jurisdiction examination before being eligible to run days, must pass commission-approved examination before being eligible to run

3rd Offense (365-day period) in any Disqualification and loss ofpurse. Horse must pass Loss ofpurse. Minimum $5,000 fine. Ifsame horse, placed on jurisdiction commission-approved examination before being eligible veterinarian's list for 60 days, must pass commission-approved to run examination before being eligible tor~

*Ifthe trainer has not had more than one violation within the previous two years, the Stewards/Judges are encouraged to is~ue a warning in lieu ofa fine provided the reported level is below 3.0 mcg/ml absent of aggravating factors.

After a two-year period, ifthe licensee has had no further violations, any penalty due to an overage in the 2.0-5.0 category will be expunged from the licensee's record for penalty purposes.

Association ofRacing Commissioners International, Inc. Page 30 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Recommended Penalty and Model Rule (Continued)

The recommended penalty for a violation involving a drug that carries a Category "D" penalty is a written warning to the trainer and owner. Multiple violations may result in fines and/or suspension.

:.-

Association of Racing Commissioners International, Inc. Page 31 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Recent Document Revisions

10.00 I July 2015 I Methylhexanamine Added alternative spelling Gamma Aminobutryic Acid 10.00 I July 2015 Added as Class 3, Penalty B Substance 5, 19 I (GABA) Added as Class 3, Penalty B with note to refer to ARCI Endogenous, Dietary, 9.00 I April 2015 Cobalt or Environmental Substances Schedule for threshold and penalty information 3, 18 for contrations ofless than 50 parts per billion (ppb) in blood serum or plasma Changed Penalty Class from "B" to "C" to conform to the ARCI Controlled 8.00 I December 2014 Firocoxib 5, 23 Therapeutic Medication Schedule Had been previously omitted from Listing by Classification Section, Added to 8.00 December 2014 I Acenocoumarol 25 section 8.00 December 2014 Deracoxib Corre_cted Spelling in Alphabetical Listing by Substance Section 3 8.00 December 2014 Norclostebol Corrected Spelling in Alphabetical Listmg by_S_!lbstance Section 8 8.00 December 2014 Rizatriptan Corrected Spelling in~p_habe_!ical Listing by Substance Section 10 8.00 December 2014 Dehydrochloromethyltestosterone Corrected Spelling in Alphabetical Listing by Substance Section 3 8.00 December 2014 Amiodarone Corrected Spelling_ i11 !,_i.5ting by _flassification Section 22 8.00 December 2014 2-Aminoheptane Corrected Spelling in Listing by Classification Section 22 8.00 December 2014 Corrected Spelling in Listing by Classification Section 13 8.00 December 2014 Alclofenac Assigned Penalty Class A 1, 13 Updated the recommended penalty for Ketoprofen to comply with the primary Recommended Penalties for 8.00 December 2014 threshold established in the ARCI Controlled Therapeutic Medication 29 Ketoprofen Schedule. Corrected typographical error on recommended penalties for Class B substances for licensed owners. Version 7.00 incorrectly recommended 8.00 December 2014 Class B Recommended Penalties penalties for second or third offense in the owner's lifetime. Version 8.00 28 corrects error and recommends penalty for second or third offense in 365-day ______p,_eriod. Addition is not a change ot the Uniform Classification Guidelines. Aminorex has been a DEA Schedule 1 substance. All DEA Schedule 1 substances are 8.00 December 2014 Aminorex 1, 13 considered Class 1, Penalty A substances by reference. By request, Aminorex has been listed to avoid confusion. 8.00 December 2014 Bufotenine Corrected the precursor to 5-methoxv-N-N dimethvltrvotamine 26

Association ofRacing Commissioners International, Inc. Page 32 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Approx. Version Date Drug/Substance Notes Page(s) 7.00 DILi Pergolide Added as Class 3, Pen~]!y B 8,20

I 6.00 1 December 2013 Methylhexaneamine Added as Class 1, Penalty A 7, 12 5.00 December 2012 Zilpaterol hydrochloride Moved from Class 3 to Class 2 Substance, Penalty Remains Unchanged 11, 17 5.00 December 2012 Tetramisole hydrochloride Removed from Non-Classified Substance list 26 5.00 December 2012 Ambroxol Moved fr()m Class 4, Penalty B to Class 4, Penalty C 1,22 Corrected typographical error in Drug Class (Incorrectly listed as a Class 3 4.01 October 2012 Ractopamine 9, 16 substance Corrected typographical error on Penalty Class (Listed as Penalty Class A in 4.01 October 2012 Pyrilamine 9, 20 "Listing by Classification" section. myo-inositol trispyrophosphate 4.00 I July 2012 Added as Class 1, Penalty A 7, 12 GTPP 4.00 July 2012 Benzonatate Added as Class 2, Penalty A 2, 13 3.00 December 2011 Almotriptan Co_rrected Penalty Class omission in Alphabetical Listing section of document 1, 18 3.00 December 2011 Naltrexone Corrected Penalty Class omission in Alphabetical Listing section of document 7,20 3.00 December 2011 Amiloride Corrected Penalty Class omission in Alphabetical Listing section of document 1, 22 3.00 December 2011 Butanilicaine Corrected Penalty Class omission in Alphabetical Listing section ofdocument 2, 13 3.00 December 2011 3, 4-methylenedioxy-, Corrected typographical error in Trade Name sections 1, 12 aka MDPV, ""

3.00 I December 2011 Carbazochrome Added as Class 4, Penalty C 2,22

Edited Drug Classification definitions to remove mention ofDMSO from 2.01 August 2011 Dimethylsulfoxide (DMSO) vii I Class 5 definition · Language pertaining to all drugs/substances not found in this document shall 2.00 I July 2011 <> u be considered a Class I, Penalty A Substan~ . Penalties for tests over 2.0 micrograms per milliliter ofplasma or serum but 2.00 July 2011 Phenylbutazone 29 I less than 5.0 micrograms per milliliter ofplasma or serum added. 2.00 I July 2011 Dermorphin Added as Class 1, Penalty A 3, 12 3,4-methylenedioxy-pyrovalerone, 2.00 July 2011 Added as Class 1, Penalty A 1, 12 I aka MDPV, "Bath Salts" 2.00 July 2011 Synthetic cannabis Added as Class 1, Penalty A 10, 12 2.00 July 2011 Alclomethasone Corrected typographical error in spelling 1, 22 1.01 January 2011 Methocarbamol Corrected typographical error on Penalty Class from Class B to Class C 7, 23

Association of Racing Commissioners International, Inc. Page 33 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015 Approx. Version Date Drug/Substance Notes Page(s) CTID December 2010 Zilpaterol Added as Class· 3, Penalty_a CTID December 2010 [ Dimethylsulfox.ide (DMSO) I Changed from Class 5 to Class 4 J

Association ofRacing Commissioners International, Inc. Page 34 Uniform Classification Guidelines for Foreign Substances

Version 10.00 - Revised July 2015