MONASH MEDICINE, NURSING AND
HEALTH SCIENCES
HONOURS AND GRADUATE RESEARCH 2022 PROJECTS CENTRAL CLINICAL SCHOOL
A partnership between:
monash.edu/medicine/ccs
Contents
Honours and Graduate Research study through the Central Clinical School 2
How to use this index booklet 2
Australian Centre for Blood Diseases (ACBD) 4
Baker Heart and Diabetes Institute 6
Burnet Institute 8
Department of Allergy, Immunology and Respiratory Medicine (AIRMed) 9
Department of Diabetes 10
Department of Gastroenterology 12
Department of Immunology and Pathology 13
Department of Infectious Diseases 15
Department of Medicine (Alfred) 16
Department of Medicine (Peninsula) 17
Department of Neuroscience 18
Department of Psychiatry (MAPrc and Epworth ECIMH) 23
Department of Surgery 24
Melbourne Sexual Health Centre (MSHC) 25
Cover: Monash medical students at a diabetes workshop on the Alfred Research Alliance site
Honours and Graduate Research study through the Central Clinical School Monash University’s Central Clinical School (CCS) undertakes translational research – developing insights from laboratory bench research for use in clinical therapies and treatments. Our departments and research affiliates have strong links with health care providers, ensuring that our research rapidly translates to clinical practice. booklet Undertaking Honours and postgraduate study with us will give you a wide range of opportunities to continue your studies and develop your career path This index booklet lists the Honours/PhD projects on offer into many areas of medical and clinical research. for 2016. For further information about a particular research project, see the project Projects are listed under the How to use this index booklet For information regarding description in the online following headings: This index booklet lists the Honours and postgraduate database at: Honours/Masters/PhD projects on offer study at CCS http://studentresearchprojects.m • Australian Centre for Blood for 2022. For further information about ed.monash.edu.au/. Diseases (ACBD) a particular research project, see the CCS General Honours For further information regarding project description in the online Coordinators individual research projects, • Baker Institute database at: students should approach the A/Prof Christoph Hagemeyer (Human supervisorconnect.med.monash.ed Pathology) nominated researcher • Burnet Institute u/research-projects E: [email protected] associated with that project. • Department of Allergy, For further information regarding A/Prof Margaret Hibbs (Immunology) Immunology and individual research projects, students E: [email protected] Respiratory Medicine should approach the nominated Dr Vilija Jokubaitis (Neuroscience) (AIRMed) researcher associated with that project. This booklet is meant as a guide only, E: [email protected] • Department of Diabetes as project ideas will be refined between student and supervisor. • Department of CCS BMedSc(Hons) Gastroenterology Making your application Coordinators Prof Karin Jandeleit-Dahm Applications are completed centrally • Department of Immunology E: [email protected] and Pathology through Monash University. Prospective applicants should Prof Merlin Thomas • Department of Infectious complete an application form, which E: [email protected] Diseases can be downloaded or obtained from the Faculty Office. For general information • Department of Medicine https://www.monash.edu/study/how-to- (Alfred) apply regarding Honours and postgraduate study at CCS • Department of Medicine Further information links and entry requirements: (Peninsula) Dr Joanne Mouser BMedSc(Hons) at CCS: CCS Honours Student Services • Department of E: [email protected] Neuroscience https://www.monash.edu/medicine/ccs/ P: 9903 0784 education/future-students/bmedsc- honours • Dept of Psychiatry (MAPrc Ms Sharmila Ramesh and Epworth ECIMH) Honours in Immunology & Human CCS Graduate Research Student Pathology: Services • Department of Surgery E: [email protected] https://www.monash.edu/medicine/ccs/ P: 9903 0368 • Melbourne Sexual Health education/future-students/honours Centre (MSHC) Scholarships: https://www.monash.edu/study/fees- scholarships/scholarships Masters, Doctoral, Graduate Certificate, Diploma in Clinical Research and Translational Medicine: https://www.monash.edu/medicine/ccs/ translational/about
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Career pathways in medical and clinical research at the Central Clinical School The Central Clincal School accepts Undergraduate applications in both the Bachelor of Medical Science (BMedSc) and General (Bachelor of Biomedical Science and Bachelor of Science) Honours streams. Graduate research project applications accepted include both Doctoral (PhD) and Masters (Master of Clinical Research – Translational Medicine stream, Master in Biomedical Science, Master in Biostatistics, or Master of Biomedical and Health Sciences) applications, as well as Graduate Diploma (Grad Dip) and Graduate Certificate (Grad Cert) applications. Short projects in Translational Research are also available. As our medical and translational research streams are taught by experts based in Monash’s rich network of educators, researchers as well as industry and clinical partnerships, this will provide excellent foundations and networks for future career pathways.
This booklet lists current projects available for a number of streams at the Central Clinical School.
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Australian Centre for Blood Understanding how epigenetic regulation of DNA methylation leads to blood cancers Diseases (ACBD) Supervisor(s): Prof Andrew Perkins and Dr Jessica Salmon Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Genetic modelling of Acute Erythroleukaemia Supervisor(s): Dr Catherine Carmichael Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Grad Dip
Therapeutic targeting of EMT modulators in cancer Supervisor(s): Dr Catherine Carmichael Email: [email protected] Applicable for: Masters by coursework, Hons, Associate Professor Christoph Hagemeyer (centre back row) and BMedSc(Hons) his group conduct novel nanoparticle research. Glucose responsive insulin nanoparticle for the The Australian Centre for Blood Diseases (ACBD) treatment of diabetes has many research groups investigating blood Supervisor(s): Assoc Prof Christoph Hagemeyer, cancers, thrombosis, and bleeding disorders. Dr Rong Xu and Assoc Prof Francesca Cavalieri ACBD is an international blood diseases centre with (External) recognised research, treatment, and educational Email: [email protected] programs for blood diseases. ACBD is affiliated with Applicable for: MSc, Hons, BMedSc(Hons), Short Monash University, Alfred Health, Eastern Health and projects Southern Health, and is organised into three integrated divisions: Recombinant agents for efficient and safe anticoagulation and thrombolysis • Clinical and Diagnostic Supervisor(s): Assoc Prof Christoph Hagemeyer and Haematology/Oncology Dr Be'eri Niego • Clinical and Basic Research Programs Email: [email protected] • Teaching and Education Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects The ACBD’s research falls into two main areas, Non- Malignant Haematology, and Malignant Haematology Single-chain antibody-targeted nanoparticles for & Stem Cell Transplantation. diagnosis of vascular diseases Supervisor(s): Assoc Prof Christoph Hagemeyer and See more: Dr Be'eri Niego www.monash.edu/medicine/ccs/blood-disease Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects PROJECTS AVAILABLE: Targeted virus particles for genetic transfer of fusion Analysing new targets of JAK-STAT signalling in proteins to inhibit atherosclerosis normal blood development and blood cancers Supervisor(s): Assoc Prof Christoph Hagemeyer and Supervisor(s): Prof Andrew Perkins and Dr Assoc Prof Paul Gregorevic Jessica Salmon Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons, BMedSc(Hons) Short projects
Reprograming differentiated adult cells into Targeted exosomes for the treatment of hematopoietic stem cells atherosclerosis, myocardial infarction and stroke Supervisor(s): Prof Andrew Perkins and Dr Supervisor(s): Assoc Prof Christoph Hagemeyer and Jessica Salmon Dr Rong Xu Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short project Genomics and Pre-clinical Models of Erythroleukaemia Supervisor(s): Prof Andrew Perkins and Catherine Carmichael Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
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Defining the role of Klf3 in immune activation and Novel immunosuppressive mechanisms of CTLA4 inflammation and CTLA4-Ig therapies Supervisor(s): Dr Jess Salmon and Prof Andrew Supervisor(s): Assoc Prof Ross Dickins and Dr Ethan Perkins Oxley Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Targeting Endothelial Cells to Treat End Organ Acute myeloid leukaemia differentiation therapy Damage caused by Graft vs Host Disease response and relapse Supervisor(s): Dr Maithili Sashindranath and Prof Supervisor(s): Assoc Prof Ross Dickins and Dr Harshal Nandurkar Steven Ngo Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons, BMedSc(Hons) Joint PhD/Exchange Program Identification of non-invasive biomarkers of disease Targeting Endothelial Cells to Treat Brain Injuries progression in proteasome inhibitor refractory multiple caused by Stroke myeloma patients utilising metabolomics Supervisor(s): Dr Maithili Sashindranath and Prof Supervisor(s): Dr Sridurga Mithraprabhu, Prof Andrew Harshal Nandurkar Spencer, Dr Ioanna Savvidou and Dr Tiffany Khong Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons, BMedSc
Identification of self-renewal networks in T-cell Liquid biopsy for multiple myeloma leukemia Supervisor(s): Dr Sridurga Mithraprabhu and Prof Supervisor(s): Assoc Prof Matthew McCormack Andrew Spencer Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects Targeting the Hhex transcription factor in Acute Myeloid Leukaemia The role of the MEK/ERK pathway in multiple Supervisor(s): Assoc Prof Matthew McCormack myeloma cells Email: [email protected] Supervisor(s): Dr Sridurga Mithraprabhu, Prof Andrew Applicable for: PhD, MSc, Hons, BMedSc(Hons) Spencer and Dr Tiffany Khong Email: [email protected] Unravelling the intricacies of gene regulation Applicable for: PhD, MSc, Hons, BMedSc(Hons), Supervisor(s): Dr Omer Gilan Graduate Diploma, Graduate Certificate, Short Email: [email protected] projects Applicable for: PhD, MSc, Hons Efficacy of next generation immunomodulatory drug Modelling resistance to epigenetic therapies in Acute (Imid) for the treatment of relapsed/refractory multiple Myeloid Leukaemia myeloma Supervisor(s): Dr Omer Gilan Supervisor(s): Dr Sridurga Mithraprabhu, Prof Andrew Email: [email protected] Spencer and Dr Tiffany Khong Applicable for: PhD, MSc, Hons Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), To evaluate new drugs to improve the response to Graduate Diploma, Graduate Certificate, Short traumatic brain injury projects, Joint PhD/Exchange Program Supervisor(s): Prof Robert Medcalf and Dr Charithani Keragala Development of lab-on-a-chip systems for high Email: [email protected] content cardiovascular drug screening and Applicable for: PhD, Masters by coursework, Hons development and BMedSc(Hons) Supervisor(s): Dr Warwick Nesbitt, Dr Crispin Szydzik and Prof Arnan Mitchell (External) To improve outcome of ischaemic stroke by protecting Email: [email protected] the blood-brain barrier Applicable for: PhD, MSc, Hons, BMedSc(Hons) Supervisor(s): Prof Robert Medcalf and Dr Charithani Keragala Email: [email protected] Blood platelet mechano-sensing of hyper-shear Applicable for: PhD, Masters by coursework, Hons gradients at stenosis and mechanical circulatory and BMedSc(Hons) support Supervisor(s): Dr Warwick Nesbitt, Prof Ivan Marusic (External) and Prof Andrew Ooi(External) Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
| 5 Dissecting Inflammation and Immunity in Baker Heart and Diabetes Cardiovascular Disease Supervisor(s): Dr Jonathan Noonan and Institute Prof Karlheinz Peter Email: [email protected] Applicable for: PhD, Masters by research
Antioxidant and anti-inflammatory effect of pomegranate polyphenols on diabetic cardiovascular disease Supervisor(s): Dr Judy De Haan-Klein and Prof Rebecca Ritchie Email: [email protected] Applicable for: PhD, Masters by coursework, Hons
Prof Rebecca Ritchie. Image: Baker Institute Developing gold nanoparticles for CT imaging of cardiovascular disease The Baker Institute is an independent medical Supervisor(s): Prof Karlheinz Peter and Prof Geoff research facility. The Institute’s work extends from the Pietersz laboratory-based research to wide-scale community Email: [email protected] studies with a focus on diagnosis, prevention, and Applicable for: PhD, MSc, Hons treatment of diabetes and cardiovascular disease. Development of innovative anti-inflammatory drugs The Institute’s main laboratory facilities are located at Supervisor(s): Prof Karlheinz Peter and Dr James the Alfred Research Alliance. McFadyen Email: [email protected] See more: Applicable for: PhD, MSc, Hons https://www.baker.edu.au PET imaging of activated platelets as an early diagnostic tool for cardiovascular disease and cancer PROJECTS AVAILABLE: Supervisor(s): Prof Karlheinz Peter and Prof Geoff Pietersz Understanding the fundamental links between Email: [email protected] mitochondria and skeletal muscle metabolism and Applicable for: PhD, MSc, Hons disease
Supervisor(s): Dr Brian Drew, Assoc Prof Anna Calkin Understanding the role of the circadian molecular and Dr Simon Bond clock in the development of dilated cardiac myopathy Email: [email protected] and atrial fibrillation Applicable for: PhD, MSc, Hons Supervisor(s): Dr Morag Young and Assoc Prof Julie
McMullen Brown Adipose Tissue Extracellular Vesicles: Are Email: [email protected] They Metabolic Messengers? Applicable for: PhD, MSc, Hons Supervisor(s): Dr Brian Drew and Dr Simon Bond
Email: [email protected] Understanding the role of the mineralocorticoid Applicable for: PhD, Masters by coursework, Hons receptor (MR) for regulating the PI3K pathway in
female and male hearts Investigations into a new gene in the brain that Supervisor(s): Dr Morag Young and Assoc Prof Julie regulates appetite and body weight McMullen Supervisor(s): Dr Brian Drew and Dr Yi Wang Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: PhD, Masters by coursework, Hons
A search for new biomarkers and therapeutic targets Investigating the role of OIP5-AS1 in cardiovascular in heart failure diseases Supervisor(s): Dr Morag Young and Dr Jun Yang Supervisor(s): Dr Brian Drew and Dr Aowen Zhuang Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: PhD, MSc, Hons
What is the role of the mineralocorticoid receptor in Does venous compliance influence cardiovascular diabetic cardiac myopathy? physiology in HFpEF? Supervisor(s): Dr Morag Young and Assoc Prof Judy Supervisor(s): Prof David Kaye and Assoc Prof Bing de Haan Wang Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: MSc and BMedSc(Hons)
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How do the mineralocorticoid receptor and the Activated platelets targeted drug therapy circadian clock interact to regulate heart disease? Supervisor(s): Dr Xiaowei Wang and Prof Karlheinz Supervisor(s): Dr Morag Young and Assoc Prof Colin Peter Clyne Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons Joint PhD/Exchange Program
Nuclear receptor co-regulators in heart disease and Diagnosis and therapy of inflammatory diseases using inflammation; new targets for fine-tuning receptor molecular ultrasound imaging actions in health and disease Supervisor(s): Dr Xiaowei Wang and Prof Karlheinz Supervisor(s): Dr Morag Young and Assoc Prof Colin Peter Clyne and Dr Kate Weeks Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons Joint PhD/Exchange Program Mineralocorticoid receptor signalling pathways in macrophages; new mechanisms of heart disease Diagnosis and therapy of thrombotic and inflammatory Supervisor(s): Dr Morag Young diseases using molecular magnetic resonance Email: [email protected] imaging Applicable for: PhD, MSc, Hons Supervisor(s): Dr Xiaowei Wang and Prof Karlheinz Peter Integration of population level ‘omics' data to target Email: [email protected] cardiometabolic disease Applicable for: PhD, Masters by research, Joint Supervisor(s): Prof Peter Meikle and Dr Corey Giles PhD/Exchange Program Email: [email protected] Applicable for: PhD, MSc, Hons Developing nanoparticles for targeted theranostics
delivery of drug and gene therapeutics A novel approach in improving lipidomics throughput Supervisor(s): Dr Xiaowei Wang and Prof Karlheinz for population profiling Peter Supervisor(s): Prof Peter Meikle and Dr Kevin Huynh Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons Joint PhD/Exchange Program
Plasma lipidomic profiling in type 2 diabetes and coronary artery disease Supervisor(s): Prof Peter Meikle and Dr Corey Giles Email: [email protected] Applicable for: PhD, Masters by research
Plasmalogen modulation as a therapeutic approach for fatty liver disease Supervisor(s): Prof Peter Meikle, Dr Graeme Lancaster and Dr Sudip Paul Email: [email protected] Applicable for: PhD
Unravelling the role of breast milk ether lipids in modulating immune function in early life Supervisor(s): Prof Peter Meikle, Dr Sudip Paul and Dr Satvika Burugupalli Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
Development and validation of a high throughput clinical lipidomics platform Supervisor(s): Prof Peter Meikle and Dr Thomas Meikle Email: [email protected] Applicable for: PhD, MSc, BMedSc(Hons)
Identification of additional markers of ferroptosis using mass spectrometry Supervisor(s): Prof Peter Meikle and Dr Kevin Huynh Email: [email protected] Applicable for: PhD, MSc, BMedSc(Hons)
| 7 Advancing vaccine development for infectious Burnet Institute diseases by identifying targets and mechanisms of protective immunity Supervisor(s): Dr Jack Richards and Dr Ricardo Ataide Email: [email protected] Applicable for: PhD, MSc, Hons
Novel tools and approaches for malaria elimination Supervisor(s): Dr Jack Richards and Dr Ricardo Ataide Email: [email protected] Applicable for: PhD, MSc, Hons
Prof Gilda Tachedjian in the lab. Image: Burnet Institute. Developing vaccines against malaria Supervisor(s): Prof James Beeson, Dr Gaoqian Feng, The Burnet Institute combines medical research in the Dr Herbert Opi, Dr Liriye Kurtovic laboratory and at a population level with public health Email: [email protected] action and advocacy to address major health issues Applicable for: PhD, MSc, Hons, BMedSc(Hons) of disadvantaged populations in Australia and communities in the developing world. Three major Understanding malaria transmission and immunity to health themes underpin the Burnet’s work: impact of inform malaria elimination infectious diseases, health and social issues of drug Supervisor(s): Prof James Beeson, Dr Joanne Chan, Assoc Prof Freya Fowkes use, and age-specific health issues (maternal and Email: [email protected] child health, young people's health, healthy ageing). Applicable for: PhD, MSc, Hons, BMedSc(Hons)
See more: Discovering the mechanisms and targets of immunity https://www.burnet.edu.au against malaria Supervisor(s): Prof James Beeson, Dr Herbert Opi, Dr Joanne Chan, Dr Linda Reiling PROJECTS AVAILABLE: Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Exploring the impact of immune ageing on response to infectious diseases in older people. Immunity to SARS-CoV-2 in Brazil Supervisor(s): Dr Anna Hearps and Assoc Prof Supervisor(s): Prof James Beeson, Prof Heidi Anthony Jaworowski Drummer Email: [email protected] Email: [email protected] Applicable for: Hons, Masters by coursework Applicable for: PhD, MSc, Hons
Using parasite and vector serosurveillance to inform Contraceptives, female reproductive tract malaria elimination inflammation and HIV risk Supervisor(s): Dr Freya Fowkes, Dr Julia Cutts and Dr Supervisor(s): Dr Lindi Masson Katherine O'Flaherty Email: [email protected] Email: [email protected] Applicable for: PhD Applicable for: PhD, MSc, Hons
Microbial functional properties that modulate Using parasite and vector serosurveillance to inform inflammation and HIV risk in African women malaria elimination Supervisor(s): Dr Lindi Masson and Prof Gilda Supervisor(s): Dr Freya Fowkes, Dr Julia Cutts and Dr Tachedjian Katherine O'Flaherty Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: PhD, MSc, Hons
Developing new diagnostic tests for malaria and other infectious diseases Supervisor(s): Dr Jack Richards Assoc and Prof David Anderson Email: [email protected] Applicable for: PhD, MSc, Hons
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Non-pharmacological public health interventions for Department of Allergy, preventing acute exacerbations of COPD: cross- sectional survey and qualitative interview study of Immunology and Respiratory patients and caregivers Supervisor(s): Dr Arwel Jones and Prof Anne Holland Medicine (AIRMed) Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons)
The Australian COVID-19 Frontline Health Workers Study: Understanding the Psychosocial Effects of the COVID-19 Pandemic on Frontline Health Workers and Developing Solutions for the Future Supervisor(s): Assoc Prof Natasha Smallwood and Karen Willis(External) Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects Nasal high flow therapy for people with chronic lung or heart diseases Supervisor(s): Assoc Prof Natasha Smallwood Email: [email protected] Professor Anne Holland with a patient. Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects The Department of Allergy, Immunology and Respiratory Medicine (AIRMed) is co-located with the Singing for Inspiration - a novel intervention for people Alfred Hospital, the Central Clinical School with chronic lung disease Departments of Immunology & Pathology and Supervisor(s): Assoc Prof Natasha Smallwood and Karen Willis(External) Medicine, the Baker and the Burnet research institutes Email: [email protected] enables extensive collaboration between all these Applicable for: PhD, MSc, Hons, BMedSc(Hons), groups. Short projects
Understanding psychological co-morbidities in AIRMed’s research questions are clinically driven, with patients with chronic obstructive pulmonary disease the goal of improving clinical care and treatment. The Supervisor(s): Assoc Prof Natasha Smallwood and safe, rapid, informed translation of laboratory based Karen Willis(External) research into clinical practice is a priority. The Email: [email protected] department’s research spans a unique spectrum of Applicable for: PhD, MSc, Hons, BMedSc(Hons) expertise in advanced lung diseases from asthma and Impacts of social equity measures on access to sleep apnoea to pulmonary hypertension, lung treatment and survival in lung cancer: A cross transplantation and cystic fibrosis. sectional observational study. Supervisor(s): Assoc Prof Robert Stirling and Prof See more: John Zalcberg https://www.monash.edu/medicine/ccs/airmed Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) PROJECTS AVAILABLE: Lung Cancer Screening - Dissemination and Experiences of ambulatory oxygen therapy in people Implementation Research with pulmonary fibrosis Supervisor(s): Assoc Prof Robert Stirling and Prof Supervisor(s): Prof Anne Holland and Dr Mariana John Zalcberg Hoffman Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: MSc, Hons, BMedSc(Hons) Requirements for a framework of Value Based Health Perceptions of and attitudes towards infection Care in Lung Cancer. challenge studies in COPD: cross-sectional survey Supervisor(s): Assoc Prof Robert Stirling and Prof and qualitative interview study of patients and John Zalcberg caregivers Email: [email protected] Supervisor(s): Dr Arwel Jones and Prof Anne Holland Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Victorian Lung Cancer Registry - Knowledge Applicable for: MSc, Hons, BMedSc(Hons) translation and data driven quality improvement. Supervisor(s): Assoc Prof Robert Stirling Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
| 9 Exploring the molecular consequences of processed Department of Diabetes food intake Supervisor(s): Assoc Prof Melinda Coughlan and Dr Matthew Snelson Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Characterising the complement cascade in diabetic kidney disease Supervisor(s): Assoc Prof Melinda Coughlan and Dr Sih Min Tan Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
Dietary fibre as an adjunct therapy for reducing kidney The Department of Diabetes has state-of-the-art laboratory injury in diabetes facilities. Supervisor(s): Assoc Prof Melinda Coughlan, Assoc Prof Elif Ekinci (External) and Dr Matthew Snelson The Department of Diabetes is the first – and only – Email: [email protected] university department in Australia solely dedicated to Applicable for: Masters by coursework, Hons, diabetes research and its complications. It has a broad BMedSc(Hons) range of translational research investigating both causes and clinical therapies for diabetes and its Mapping the mitochondrial signature in human complications including kidney disease, heart disease diabetic kidney disease and blindness. Some of the most important Supervisor(s): Assoc Prof Melinda Coughlan discoveries in diabetes and its complications are yet to Email: [email protected] Applicable for: PhD, Masters by coursework, Hons be unravelled and converted into innovative treatments and clinical outcomes. Targeting inflammatory pathways as a novel treatment for diabetic kidney disease. See more: Supervisor(s): Dr Phillip Kantharidis, Dr Madhura www.monash.edu/medicine/ccs/diabetes Bose and Dr Muthu Mohan Email: [email protected] PROJECTS AVAILABLE: Applicable for: PhD, MSc, Hons, BMedSc Anti-fibrotic and/or anti-inflammatory compound/s for the treatment of heart failure Novel anti-inflammatory agents targeting Supervisor(s): Assoc Prof Bing Wang and Prof David atherosclerosis development in diabetes Kaye Supervisor(s): Dr Phillip Kantharidis, Dr Madhura Email: [email protected] Bose and Dr Muthu Mohan Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, Circulating microRNAs as biomarkers for BMedSc cardiovascular diseases Supervisor(s): Assoc Prof Bing Wang and Prof David International Consortium Study Investigating DNA Kaye Methylation and Risk of Diabetic Complications Email: [email protected] Supervisor(s): Prof Sam El-Osta, Dr Ishant Khurana, Applicable for: PhD, MSc, Hons, BMedSc(Hons) Dr Scott Maxwell, Prof Mark Cooper, Prof Peter Dissecting the role of calprotectin (S100 A8/A9) in the Rossing (External), Prof Per-Henrik Groop (External), role of inflammation Prof Juliana Chan (External), Prof Ronald Ma (External), Prof Thep Himathongkam (External) and Supervisor(s): Dr Carlos Rosado, Prof Merlin Thomas Email: [email protected] Dr Yotsapon Thewjitcharoen (External) Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: PhD The role of Nox5 in diabetes associated complications Supervisor(s): Dr Jay Jha, Prof Karin Jandeleit-Dahm The legacy of hyperglycaemic memory Supervisor(s): Prof Sam El-Osta, Prof Harikrishnan Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Kaipananickal, Dr Jun Okabe, Dr Scott Maxwell and Joint PhD/Exchange Program Dr Ishant Khurana Email: [email protected] The role of Nox5 in diabetic kidney disease Applicable for: PhD, Masters by research Supervisor(s): Dr Jay Jha, Prof Karin Jandeleit-Dahm Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons), Graduate Diploma, Joint PhD/Exchange Program
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Set7 methyltransferase as a target to reduce the Role of epigenetic modifier EZH2 in diabetes burden of diabetic complications associated endothelial cell dysfunction Supervisor(s): Prof Sam El-Osta, Dr Jun Okabe, Supervisor(s): Dr Waheed Khan and Prof Karin Dr Harikrishnan KN and Dr Scott Maxwell jandeleit-dahm Email: [email protected] Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, Applicable for: Masters by coursework, Hons BMedSc(Hons) Role of AP-1 transcription factor cFOS in diabetes Clinical epigenetics and molecular based therapies associated atherosclerosis Supervisor(s): Prof Sam El-Osta, Dr Harikrishnan Supervisor(s): Dr Waheed Khan and Prof Karin Kaipananickal, Dr Jun Okabe and Dr Scott Maxwell jandeleit-dahm Email: [email protected] Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, Applicable for: Masters by coursework, Hons BMedSc(Hons)
Role of non-coding RNAs in vascular disease Supervisor(s): Prof Sam El-Osta, Dr Harikrishnan Kaipananickal and Dr Jun Okabe Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
Pancreas regeneration for diabetes cure Supervisor(s): Prof Sam El-Osta, Dr Keith Al-Hasani and Dr Ishant Khurana Email: [email protected] Applicable for: PhD, MSc, BMedSc(Hons)
Development of stealth microencapsulation for cell- based therapies Supervisor(s): Prof Sam El-Osta, Dr Keith Al-Hasani, Dr Angus Johnston and Dr Georgina Such(External) Email: [email protected] Applicable for: PhD, Masters by research
Influence of epigenetic modifications in the clinical remission phase (honeymoon period) of adult-onset Type 1 Diabetes Supervisor(s): Prof Sam El-Osta, Dr Scott Maxwell, Dr Ishant Khurana, Dr Yotsapon Thewjitcharoen(External) and Dr Thep Himathongkam(External) Email: [email protected] Applicable for: PhD, Masters by research
Atypical diabetes mellitus associated with Kabuki syndrome Supervisor(s): Prof Sam El-Osta, Dr Ishant Khurana, Dr Scott Maxwell, Dr Jun Okabe, Dr Harikrishnan KN, Dr Yotsapon Thewjitcharoen (External) and Dr Thep Himathongkam (External) Email: [email protected] Applicable for: PhD, Masters by research
A twin approach to unraveling the epigenetics of POTS Supervisor(s): Prof Sam El-Osta, Dr Harikrishnan KN, Dr Jun Okabe and Dr Scott Maxwell Email: [email protected] Applicable for: PhD, Masters by research
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Department of Investigating the clinical utility of dietary strategies in ulcerative colitis Gastroenterology Supervisor(s): Dr Chu (CK) Yao and Prof Peter Gibson Email: [email protected] Applicable for: PhD
Dr CK Yao (right) presenting at a weekly seminar. The Department of Gastroenterology undertakes research in gastroenterology and intestinal health and disease in a variety of specialist areas including nutrition, chronic liver and bowel disease, viral hepatitis and endoscopy. It is internationally recognised for its high-impact research and clinical expertise, including the invention of the low FODMAP (fermentable oligo-, di-, mono-saccharides and polyols) diet.
See more: www.monash.edu/medicine/ccs/gastroenterology
PROJECTS AVAILABLE: Developing improved therapeutic strategies targeting GC Supervisor(s): Prof Alex Boussioutas and Dr Rita Busuttil (External) Email: [email protected] Applicable for: PhD, MSc, Hons
Investigating the innate and adaptive immune response in gastric cancer Supervisor(s): Prof Alex Boussioutas and Dr Rita Busuttil (External) Email: [email protected] Applicable for: PhD, MSc, Hons
Role of the tumour microenvironment in gastric cancer Supervisor(s): Prof Alex Boussioutas and Dr Rita Busuttil (External) Email: [email protected] Applicable for: PhD, MSc, Hons
Functional characterization of candidate genes involved in the progression of gastric cancer Supervisor(s): Prof Alex Boussioutas and Dr Rita Busuttil (External) Email: [email protected] Applicable for: PhD, MSc, Hons
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Repurposing of immunotherapies for severe urinary Department of Immunology tract infection and associated renal complications Supervisor(s): Dr Malcolm Starkey and Dr Samuel and Pathology Forster Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Harnessing the immune system for organ repair in kidney stone diseases Supervisor(s): Dr Malcolm Starkey and Dr Bernadette Jones-Freeman Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Type 2 immunity in the urinary tract Supervisor(s): Dr Malcolm Starkey and Dr Bernadette Jones-Freeman Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Dr Malcolm Starkey’s group in 2020. The Monash University Department of Immunology Programming stochastic cytokine expression in T cells. and Pathology is internationally renowned for its Supervisor(s): Dr Marcus Robinson and Prof David combined expertise in research, teaching and service Tarlinton delivery in immunology and immunopathology. Email: [email protected] Applicable for: Masters by coursework, Hons, There are extensive research programs in basic and BMedSc(Hons) translational immunology, including highly successful collaborations with the Alfred hospital and other ARA Determining the lifespan and mechanisms regulating partners. The department’s research activities target survival of IgE plasma cells diseases including allergy, asthma, autoimmunity, Supervisor(s): Dr Marcus Robinson and Prof David inflammation, immunodeficiency, lupus, organ Tarlinton fibrosis, cancer and helminth infection. The Email: [email protected] Applicable for: PhD department also focuses on investigating novel treatments, such as the regulation of the microbiota in The B-ginnings of natural antibody disease. Supervisor(s): Dr Marcus Robinson and Prof David Tarlinton See more: Email: [email protected] www.monash.edu/medicine/ccs/immunology Applicable for: Masters by coursework, Hons, BMedSc(Hons) PROJECTS AVAILABLE: Do lymphatic growth factors play an important role in Discover targets of long-lived humoral immunity for the immune system? Strep A vaccine design. Supervisor(s): Assoc Prof Margaret Hibbs and Evelyn Supervisor(s): Dr Danika Hill and Prof David Tarlinton Tsantikos Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: PhD, MSc, Hons
A comparison of technology-integrated pedagogical Are immunometabolic processes perturbed in chronic approaches for immunology and pathology inflammatory disease? undergraduate teaching Supervisor(s): Assoc Prof Margaret Hibbs and Evelyn Supervisor(s): Dr Jessica Borger and Prof Robyn Tsantikos Slattery Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons Applicable for: Hons, Masters by coursework Beyond rare monogenetic variants in predominantly Understanding how group 2 innate lymphoid cells in antibody deficiency early life regulate postnatal lung development and Supervisor(s): Assoc Professor Menno Van Zelm, Dr susceptibility to chronic respiratory diseases Emily Edwards and Prof Robyn O'Hehir Supervisor(s): Dr Malcolm Starkey and Dr Bernadette Email: [email protected] Jones-Freeman Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
| 13 Longevity of B-cell memory following natural infection or vaccination Supervisor(s): Assoc Professor Menno Van Zelm, Prof Robyn O'Hehir and Prof P. Mark Hogarth Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Immune specificity and memory in asthma and allergic disease Supervisor(s): Assoc Professor Menno Van Zelm and Prof Robyn O'Hehir Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Targeting the blood feeding pathway of the hookworm parasites Supervisor(s): Prof Nicola Harris and Dr Tiffany Bouchery Email: [email protected] Applicable for: Hons
Targeting the Alox15 pathway to control dysregulated tissue remodelling Supervisor(s): Prof Nicola Harris and Prof Benjamin Marsland Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
Investigating the neuro-immune interactions in the enteric nervous system during homeostasis and infection Supervisor(s): Prof Nicola Harris and Mr Haozhoe Wang Email: [email protected] Applicable for: Masters by coursework, Hons, BMedSc(Hons)
Immune-eptihelail cell crosstalk in chronic lung disease (emphysema) Supervisor(s): Prof Nicola Harris Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
The potential of T-cell immune profiles as new biomarkers for predicting relapse in diffuse large B cell lymphoma Supervisor(s): Dr Zhoujie Ding Email: [email protected] Applicable for: Masters by coursework, Hons
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Combating antimicrobial resistance through use of Department of Infectious genomics and artificial intelligence Supervisor(s): Dr Nenad Macesic, Prof Anton Peleg Diseases and Dr Sonika Tyagi Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects
Tackling superbugs: development of an integrated antimicrobial resistance infection prevention genomics service Supervisor(s): Dr Nenad Macesic and Prof Anton Peleg Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects
Carbapenem resistance in the Australian setting: The department has a major focus on combating antimicrobial using genomics to understand the spread of deadly resistance. pathogens Supervisor(s): Dr Nenad Macesic and Prof Anton The Department of Infectious Diseases, Central Peleg Clinical School and Alfred Health, incorporates a large Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), clinical service with active research programs in the Short projects fields of HIV, viral hepatitis, infections in the immunosuppressed (such as those with malignancy, Perioperative carriage of antimicrobial resistant in intensive care, and post-splenectomy), influenza, (AMR) organism and the development of surgical site drug resistant organisms, antibiotic use and infection infections in joint replacement surgery. prevention and hospital epidemiology. The Supervisor(s): Dr Trisha Peel and Dr Jessica Department of Infectious Diseases integrates clinical Wisniewski Email: [email protected] services with clinical and basic science research with Applicable for: Masters by coursework, Hons laboratories based within the Burnet Institute building. BMedSc(Hons)
See more: www.monash.edu/medicine/ccs/infectious-diseases
PROJECTS AVAILABLE:
Using whole genome sequencing to understand the evolution of Shigella and enteroinvasive E. coli Supervisor(s): Dr Jane Hawkey and Prof Kathryn Holt Email: [email protected] Applicable for: Masters by coursework, Hons, BMedSc(Hons)
Metabolic diversity of Klebsiella pneumoniae and association with ecological niche Supervisor(s): Dr Kelly Wyres and Prof Kathryn Holt Email: [email protected] Applicable for: PhD
Metabolic modelling and nutrient utilisation of Klebsiella interspecies hybrids Supervisor(s): Dr Kelly Wyres and Dr Ben Vezina Email: [email protected] Applicable for: Masters by coursework, Hons
Understanding the changes in hospital patient movement flows due to COVID-19 and the effects on hospital acquired infections using network dynamics Supervisor(s): Dr Michael Lydeamore Email: [email protected] Applicable for: MSc, Hons | 15 Department of Medicine (Alfred)
Astrocytes by Be’eri Niego.
The research expertise of the Department of Medicine spans six laboratories, working on health issues crucial to today’s society including skin cancer, multiple sclerosis, dermatology, developmental biology, endocrinology and oncology. Many programs are closely integrated with clinical services at Alfred Health, which allows findings to be rapidly translated to therapeutics and health care.
See more: https://www.monash.edu/medicine/ccs/medicine- alfred/research
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Academic Unit staff, Medicine, Peninsula Health
Department of Medicine (Peninsula) The Academic Unit, Medicine, Peninsula Health, is comprised of researchers with vaired but complementary skill sets whose goal is to conduct high quality translational research into chronic conditions affecting the ageing population. Expertise spans from clinical medicine, bioinformatics and imaging, health services research including data linkage, and biostatistics. Major initiatives include the study of poor metabolic health (e.g. obesity, type 2 diabetes) and dementia, cerebrovascular disease and dementia, frailty and delirium in hospitalized older people, novel technologies for designing health service delivery for stroke, and community systems of care for people with dementia. Members of the group have several local, national and international collaborations.
See more: https://www.monash.edu/medicine/ccs/medicine- alfred/research/srikanth-group
PROJECTS AVAILABLE:
The COLPLAQUE Study - A Multicentre CTCA trial examining the role of colchicine to reduce coronary inflammation in the treatment of patients with Acute Coronary Syndromes. Supervisor(s): Dr Jamie Layland Email: [email protected] Applicable for: Masters by coursework, BMedSc(Hons)
| 17 The Department of Neuroscience uses an extensive, sophisticated and pioneering suite of platform technologies at the Alfred Research Alliance to undertake its basic research. L-R are Dr Karen Alt (Australian Centre for Blood Diseases), Dr Robert Brkljaca (Monash Biomedical Imaging) and Dr Bianca Jupp (Department of Neuroscience, who are all involved in the design of experiments involving pre-clinical imaging.
Department of Neuroscience Can digital technology in the Multiple Sclerosis Clinic The Department of Neuroscience has over 200 detect subclinical neurological decline? Supervisor(s): Assoc Prof Anneke Van Der Walt, researchers and graduate students across a wide Prof Helmut Butzkueven, Dr Melissa Gresle, Assoc spectrum of neurological disorders. The specialist Prof Adam Vogel(External) and Dr Scott Kolbe areas of the department are investigation of Email: [email protected] neurological, neuroscience, neurobehavioural, Applicable for: PhD pharmacological and imaging based projects with respect to cognition and various brain disorders Epilepsy in a Dish – Finding cures for epilepsy using stem cell-based disease models. including epilepsy, neuroinflammation, Supervisor(s): Dr Ben Rollo, Dr Pablo-Casillas- neurodegenerative diseases, brain tumours, stroke Espinosa, Dr Ana Antonic-Baker, Prof Terence and traumatic brain injury. O'Brien and Prof Patrick Kwan Email: [email protected] See more: Applicable for: MSc, Hons, BMedSc(Hons) www.monash.edu/medicine/ccs/neuroscience Physical and Neural Rehabilitation in Parkinson’s Disease PROJECTS AVAILABLE: Supervisor(s): Dr Ben Sinclair and Prof Meng Law Developing a signature of the epileptogenic zone with Email: [email protected] stereo-EEG and cortical stimulation Applicable for: Masters by coursework, Hons Supervisor(s): Dr Andrew Neal, Assoc Prof Nigel Jones, and Dr Matthew Hudson Waste Clearance in Neurological Disorders Email: [email protected] Supervisor(s): Dr Ben Sinclair and Prof Meng Law Applicable for: PhD, Masters by research Email: [email protected] Applicable for: Masters by coursework, Hons
Quality of life, satisfaction and tolerability associated Machine Learning in Neuroscience with stereo-EEG and radio-frequency thermo- Supervisor(s): Dr Ben Sinclair and Prof Meng Law coagulation Email: [email protected] Supervisor(s): Dr Andrew Neal and Dr Genevieve Applicable for: Masters by coursework, Hons Rayner Email: [email protected] Investigating the role of neuroinflammation in Applicable for: PhD, MSc, Hons impulsivity Supervisor(s): Dr Bianca Jupp Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) 18 |
Investigating the influence of striatal and midbrain Sodium Imaging in mild Traumatic Brain Injury dopamine D2 receptors on impulsivity and function of Supervisor(s): Assoc Prof David Wright and Dr Akram the prefrontal cortex Zamani Supervisor(s): Dr Bianca Jupp Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: MSc, Hons, BMedSc(Hons) Assessing Glymphatic Pathway function in Motor Investigating the role of individual differences in sleep Neuron Disease using MRI and sleep deprivation in risk for alcohol use disorder Supervisor(s): Assoc Prof David Wright and Dr Akram Supervisor(s): Dr Bianca Jupp Zamani Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Social rehabilitation to rescue social deficits after Neuroimaging of Brain Networks in Rare paediatric brain injury Neurodegenerative Diseases Supervisor(s): Dr Bridgette Semple and Assoc Supervisor(s): Dr Ian Harding, Assoc Prof Adeel Razi Prof Richelle Mychasiuk and Dr Rebecca Kerestes Email: [email protected] Email: [email protected] Applicable for: Masters by coursework, Hons, Applicable for: PhD, MSc, Hons, BMedSc(Hons) BMedSc(Hons) Cutting-Edge Neuroimaging for Understanding Myelin damage and repair after traumatic brain injury Neurodegenerative Diseases in early life Supervisor(s): Dr Ian Harding, Prof Gary Egan and Supervisor(s): Dr Bridgette Semple and Dr David Lucy Vivash Gonsalvez Email: [email protected] Email: [email protected] Applicable for: PhD Applicable for: MSc, Hons, BMedSc(Hons) Defining Patterns of Brain Degeneration using Patient and family attitudes towards novel treatments Neuroimaging: An International Collaborative Study after traumatic brain injury Supervisor(s): Dr Ian Harding, Dr Rebecca Kerestes Supervisor(s): Dr Bridgette Semple, Dr Sandra Braff and Dr David Szmulewicz and Prof Natasha Lannin Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: MSc, Hons, BMedSc(Hons) Tracking Cognition, Speech, Affect, and Motor Understanding the role of growth factor VEGF-D in Function in Rare Brain Diseases brain health and injury Supervisor(s): Dr Ian Harding, Dr David Szmulewicz Supervisor(s): Dr Bridgette Semple, Prof Margaret (Neurologist) and Dr Louisa Selvadurai Hibbs and Dr Tim Gottschalk (Neuropsychologist) Email: [email protected] Email: [email protected] Applicable for: Masters by coursework, Hons, Applicable for: PhD, MSc, Hons, BMedSc(Hons) BMedSc(Hons) Neuroimaging and Behavioural Characterisation of a Infections and epilepsy after traumatic brain injury New Genetic Brain Disease Supervisor(s): Dr Bridgette Semple, Prof Terence Supervisor(s): Dr Ian Harding, and Dr David O’Brien and Prof Jian Li Szmulewicz Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Sleep disorders after traumatic brain injury - PET imaging of neuroinflammation as biomarker of translational research approaches post-traumatic epilepsy Supervisor(s): Dr Bridgette Semple, Assoc Supervisor(s): Dr Idrish Ali, Prof Terence O'Brien, Prof Richelle Mychasiuk and Prof Natasha Lannin Dr Lucy Vivash and Assoc Prof Nigel Jones Email: [email protected] Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons) BMedSc(Hons)
New Biomarkers for mild Traumatic Brain Injury: Role of microglia in development of epilepsy and CEST MRI behavioural comorbidities after a traumatic brain Supervisor(s): Assoc Prof David Wright and Dr Akram injury Zamani Supervisor(s): Dr Idrish Ali, Assoc Prof Nigel Jones Email: [email protected] and Dr Bridgette Semple Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
| 19 Exploring the neuropathological underpinnings of visual snow using MRI techniques Oculomotor function in autoimmune encephalitis Supervisor(s): Assoc Prof Joanne Fielding, Dr Supervisor(s): Dr Mastura Monif, Assoc Prof Joanne Meaghan Clough and Dr Scott Kolbe Fielding, Dr Meaghan Clough and Prof Owen White Email: [email protected] Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, Applicable for: PhD, MSc, Hons, BMedSc(Hons) BMedSc(Hons) Controlling brain cells with light: Investigating the role Visual snow: a behavioural perspective of high frequency brain rhythms in cognitive Supervisor(s): Assoc Prof Joanne Fielding and Dr processing. Meaghan Clough Supervisor(s): Dr Matt Hudson and Assoc Prof Nigel Email: [email protected] Jones Applicable for: PhD, Masters by coursework, Hons, Email: [email protected] BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Longitudinal assessment of cognitive change in REVIVER: A novel exercise device for the treatment multiple sclerosis of Parkinson's disease Supervisor(s): Assoc Prof Joanne Fielding and Dr Supervisor(s): Dr Meaghan Clough, Assoc Meaghan Clough Prof Joanne Fielding and Dr Ben Sinclair Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: Masters by coursework, Hons, BMedSc(Hons) The effect of anti-epileptic drugs on cerebellar volume and metabolism in patients with epilepsy Neural oscillations and cognition Supervisor(s): Dr Lucy Vivash, Dr Ben Sinclair and Supervisor(s): Assoc Prof Nigel Jones and Dr Matt Prof Terence O'Brien Hudson Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Sodium selenate as a treatment for behavioural NMDA receptors, neural oscillations and cognition variant fronto-temporal dementia Supervisor(s): Assoc Prof Nigel Jones and Dr Matt Supervisor(s): Dr Lucy Vivash, Dr Charles Malpas Hudson and Prof Terence O'Brien Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons) The role of microglial cells in epilepsy pathogenesis Imaging of neurodegenerative diseases Supervisor(s): Assoc Prof Nigel Jones, Dr Idrish Ali Supervisor(s): Dr Lucy Vivash and Prof Terence and Dr Bridgette Semple O'Brien Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects, Joint PhD/Exchange Program A new brain stimulation paradigm to treat depression Supervisor(s): Assoc Prof Nigel Jones, Dr Matt Sodium selenate as a treatment for progressive Hudson and Dr Bridgette Semple supranuclear palsy Email: [email protected] Supervisor(s): Dr Lucy Vivash and Prof Terence Applicable for: PhD, MSc, Hons, BMedSc(Hons) O'Brien Email: [email protected] Stimulating the brain to treat epilepsy Applicable for: PhD, MSc, Hons, BMedSc(Hons), Supervisor(s): Assoc Prof Nigel Jones, Dr Matt Short projects, Joint PhD/Exchange Program Hudson, Dr Idrish Ali and Dr Juliana Silva Email: [email protected] Monocytes in Multiple Sclerosis Applicable for: PhD, MSc, Hons, BMedSc(Hons) Supervisor(s): Dr Mastura Monif and Prof Helmut Butzkueven Boosting brain rhythms as a new therapy for Email: [email protected] schizophrenia Applicable for: PhD, MSc, Hons, BMedSc(Hons) Supervisor(s): Assoc Prof Nigel Jones and Dr Rachel Hill Activated microglia in human brain tumours - a Email: [email protected] translational study. Applicable for: PhD, MSc, Hons, BMedSc(Hons) Supervisor(s): Dr Mastura Monif, Prof Terry O'Brien and Assoc Prof Martin Hunn Using AI to decode neural signatures of cognition Email: [email protected] Supervisor(s): Assoc Prof Nigel Jones and Dr Matt Applicable for: PhD, MSc, Hons, BMedSc(Hons) Hudson Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons)
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Management and prognosis of first seizure and newly Investigating the role of a Cav3.2 calcium channel diagnosed epilepsy mutation in contributing to the epileptic phenotype Supervisor(s): Prof Patrick Kwan and Dr Zhibin Chen using congenic rat strains Email: [email protected] Supervisor(s): Dr Pablo Casillas-Espinosa and Prof Applicable for: PhD, MSc, Hons, BMedSc(Hons) Terence O'Brien Email: [email protected] Wearable devices for non-invasive, ambulatory Applicable for: PhD, MSc, Hons, BMedSc(Hons), seizure monitoring and prediction Short projects Supervisor(s): Prof Patrick Kwan and Prof Terence O'Brien Neuropharmacological strategies for disease Email: [email protected] modification and prevention of the development of Applicable for: PhD, MSc, Hons, BMedSc(Hons) epilepsy Supervisor(s): Dr Pablo Casillas-Espinosa, Prof Clinical utility and cost-effectiveness of genomic Terence O'Brien, Assoc Prof Sandy Shultz and Assoc sequencing for epilepsy Prof Nigel Jones Supervisor(s): Prof Patrick Kwan and Dr Alison Email: [email protected] Anderson Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Applicable for: Applicable for: PhD, MSc, Hons, Biomarkers of epileptogenesis and epilepsy disease BMedSc(Hons) progression Supervisor(s): Dr Pablo Casillas-Espinosa, Prof Predictors and mechanisms of cutaneous adverse Terence O'Brien, Dr Idrish Ali, Assoc Prof Nigel Jones drug reactions: a multi-omic approach and Assoc Prof Sandy Shultz Supervisor(s): Prof Patrick Kwan and Dr Alison Email: [email protected] Anderson Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Genetic determinants of temporal lobe epilepsy - a translational investigation Long-term Prognosis of Antiepilpetic Drug Therapy in Supervisor(s): Dr Pablo Casillas-Espinosa, People with Newly Diagnosed and Treated Epilepsy Prof Terence O'Brien, Dr Alison Anderson and Supervisor(s): Prof Patrick Kwan, Dr Zhibin Chen and Dr Bridgette Semple Dr Zongyuan Ge Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Evaluating novel therapies to prevent post-stroke Treatment Gap in People with Newly Diagnosed epilepsy and associated neurological impairments Epilepsy in Australia Supervisor(s): Dr Pablo Casillas-Espinosa, Assoc Supervisor(s): Prof Patrick Kwan and Dr Zhibin Chen Prof Sandy Shults and Prof Terence O'Brien Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons) Investigating the role of genetic variants in drug- Drug repurposing in neurological disorders resistant epilepsy Supervisor(s): Dr Pablo Casillas-Espinosa, Supervisor(s): Prof Patrick Kwan, Prof Terence Prof Terence O'Brien, Dr Ralph Schittenhelm, O'Brien and Dr Alison Anderson Dr Alison Anderson and Dr Ben Rollo Email: [email protected] Email: [email protected] Applicable for: Masters by coursework, Hons Applicable for: PhD, MSc, Hons, BMedSc(Hons) Curating structural variants in epilepsy Development of a low cost, point-of-care diagnostic Supervisor(s): Prof Patrick Kwan and Dr Alison platform Anderson Supervisor(s): Prof Patrick Kwan and Dr Jianxiong Email: [email protected] Chan Applicable for: PhD, MSc, Hons Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Investigating the Transition from Acute to Chronic Pain Following Mild Traumatic Brain Injury Acquired epilepsy in Alzheimer’s disease Supervisor(s): Assoc Prof Richelle Mychasiuk and Supervisor(s): Prof Patrick Kwan and Assoc Prof Dr Rhys Brady Nigel Jones Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
| 21 The Effects of Orexin Modulation on Sleep, Sodium Selenate as a Disease Modifying Treatment Glymphatic Function, and Recovery from Repetitive for Probable Behavioural Variant Front-temporal Mild Traumatic Brain Injury (TBI) Dementia and Progressive Supranuclear Palsy Supervisor(s): Assoc Prof Richelle Mychasiuk and Supervisor(s): Prof Terence O'Brien, Dr Lucy Viviash, Assoc Prof Sandy Shultz Dr Charles Malpas and Prof Dennis Velakoulis Email: [email protected] (External) Applicable for: PhD, MSc, Hons, BMedSc(Hons) Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), The Role of the Microbiome in Recovery from Grad Diploma, Short projects Repetitive Mild Traumatic Brain Injury Supervisor(s): Assoc Prof Richelle Mychasiuk Whole genomic sequencing analysis of genetic and Email: [email protected] acquired rat strains Applicable for: PhD, MSc, Hons Supervisor(s): Prof Terence O'Brien, Dr Pablo Casillas-Espinosa and Dr Bridgette Semple Investigating the Role of the Circadian System in Email: [email protected] Traumatic Brain Injury Applicable for: PhD, MSc, Hons, BMedSc(Hons), Supervisor(s): Assoc Prof Richelle Mychasiuk and Grad Diploma, Short projects Dr Glenn Yamakawa Email: [email protected] Pharmacogenomic studies in Multiple Sclerosis Applicable for: PhD, MSc, Hons Supervisor(s): Dr Vilija Jokubaitis, Prof Helmut Butzkueve and Dr Omar Ibrahim Are spike-wave discharges biomarkers of the Email: [email protected] development of epilepsy after traumatic brain injury? Applicable for: PhD, Masters by coursework, Hons, Supervisor(s): Miss Rui Li, Prof Terence O'Brien and BMedSc(Hons) Dr Pablo Casillas-Espinosa Email: [email protected] Women's Health in Multiple Sclerosis: Investigating Applicable for: PhD, MSc, Hons, BmedSc(Hons) long-term impact of hormones and pregnancy on MS outcomes, and the impact of MS therapies on cervical High-frequency oscillations as biomarkers of dysplasia risk ictogenesis and epileptogenesis Supervisor(s): Dr Vilija Jokubaitis, Assoc Prof Anneke Supervisor(s): Miss Rui Li, Dr Matt Hudson and van der Walt and Assoc Prof Julia Dr Pablo Casillas-Espinosa Brotherton(External) Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BmedSc(Hons) Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons) Advanced MRI for monitoring neurological disease Supervisor(s): Dr Scott Kolbe and Prof Meng Law Diet and Multiple Sclerosis Email: [email protected] Supervisor(s): Dr Vilija Jokubaitis and Ms Neha Kaul Applicable for: PhD, MSc, Hons, BmedSc(Hons) Email: [email protected] Applicable for: Masters by coursework, Hons, A Pharmacogenomics study of the teratogenicity BMedSc valproate based on the prospective Australian Register for Anti-epileptic Drugs in Pregnancy Mendelian Randomisation studies in Multiple Supervisor(s): Prof Terence O'Brien, Prof Frank Vajda Sclerosis (External), Dr Alison Anderson, Dr Charles Malpas Supervisor(s): Dr Vilija Jokubaitis and Dr Omar and Dr Piero Perucca Ibrahim Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: Masters by coursework, Hons, Grad Diploma, Short projects BMedSc
Identifying Predictors of Death in Patients with Epileptic and Psychogenic Seizures Supervisor(s): Prof Terence O'Brien, Prof Patrick Kwan, Dr Shobi Sivathamboo and Dr Charles Malpas Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Grad Diploma, Short projects
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Does regular mindfulness meditation alter neural Department of Psychiatry inhibition / excitation balances? An EEG investigation. Supervisor(s): Dr Neil Bailey (MAPrc and Epworth ECIMH) Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
Is heart rate activity more dynamically modulated by neural activity in mindfulness meditators? Supervisor(s): Dr Neil Bailey Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
MAPrc researchers EEG measures of mindfulness meditation - a meta- analysis Monash Alfred Psychiatry research centre (MAPrc) is Supervisor(s): Dr Neil Bailey one of Australia’s largest clinical research centres in Email: [email protected] psychiatry. The centre has a long track record of Applicable for: Masters by coursework, Hons, producing world class research with direct clinical BMedSc(Hons) translation. Can cognitive or resting EEG data reveal biomarkers The key goal of MAPrc is to conduct clinical research related to mental illness diagnoses? Supervisor(s): Dr Neil Bailey and Prof Kate Hoy aimed at developing new treatments with direct, Email: [email protected] effective, and immediate applications. The research Applicable for: Masters by coursework, Hons, covers all ages and many different mental illnesses. BMedSc(Hons) MAPrc research is integrated with clinical practice, based in the Alfred Hospital in affiliation with Monash Do cognition related EEG measures show similar University. brain activity across tasks? A large-scale replication study.
Supervisor(s): Dr Neil Bailey and Prof Kate Hoy We have a multidisciplinary group of researchers with Email: [email protected] a research agenda that meets clinical and social Applicable for: Masters by coursework, Hons needs and has a short 1–5 year timeline to real clinical impact. Diversity and Clinical Neuroscience: Increasing the equity and generalisability of neuroscience based See more: treatments. www.maprc.org.au Supervisor(s): Dr Neil Bailey and Prof Kate Hoy Email: [email protected] Applicable for: PhD, Masters by research PROJECTS AVAILABLE: Generating a New Understanding of Brain Function in Impact of type and timing of childhood trauma on Mental Illness - Do EEG measures of the Excitation / adult cognition and psychopathology Inhibition Balance Predict Mental Illness? Supervisor(s): Dr Caroline Gurvich, Prof Jayashri Supervisor(s): Dr Neil Bailey and Prof Kate Hoy Kulkarni and Dr Natalie Thomas Email: [email protected] Email: [email protected] Applicable for: Masters by coursework, Hons Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons) Does mindfulness improve mental health in university students? A meta-analysis. Cognitive functioning and emotion processing during Supervisor(s): Dr Neil Bailey the menopause transition Email: [email protected] Supervisor(s): Dr Caroline Gurvich and Dr Natalie Applicable for: Masters by coursework, Hons Thomas Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
Sex hormones and cognitive changes with aging Supervisor(s): Dr Caroline Gurvich and Prof Kate Hoy Email: [email protected] Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
| 23 The Impact of Low-to-intermediate Risk Thyroid Department of Surgery Cancer Diagnosis and Treatment on the Patient’s Quality of Life - a cross-sectional study to facilitate assisted decision-making and peer-group benchmarking Supervisor(s): A/Prof. James Lee, Dr Liane Ioannou, Prof Jonathan Serpell and Prof Jeremy Millar Email: [email protected] Applicable for: PhD, MSc, Hons
Accuracy and Clinical Utility of Genomic Profiling using Next Generation Sequencing of Thyroid FNA Samples Supervisor(s): A/Prof. James Lee and Dr Costas Yannakou(External) Email: [email protected] Applicable for: PhD, Masters by research
Dr Cheng Lo (left) and Assoc Prof Heather Cleland about to go into theatre. Measuring the inflammatory response to bariatric surgery The Department of Surgery is a centre for clinical and Supervisor(s): Dr Paul Burton surgical research and education, contributing to Email: [email protected] Monash's MBBS and offering postgraduate study Applicable for: PhD, MSc, Hons, BMedSc(Hons) programs. Surgical techniques and applications are Outcomes of gastro-oesophageal cancer in Victoria constantly evolving. Research in the Department of Supervisor(s): Dr Paul Burton Surgery includes programs in a wide variety of areas Email: [email protected] such as trauma, burns, cardiothoracic, colorectal, Applicable for: PhD, MSc, Hons, BMedSc(Hons) endocrine, upper gastrointestinal, urology, orthopaedics, spine injury, general surgery and Obesity related systemic inflammation as a driver of neurosurgery specialisations. Non-alcoholic fatty liver disease Supervisor(s): Dr Paul Burton The Department of Surgery is closely associated with Email: [email protected] the National Trauma Research Institute. Applicable for: PhD, MSc, Hons, BMedSc(Hons)
See more: Examining the inflammatory profile of adipose tissue www.monash.edu/medicine/ccs/surgery-alfred in oesophageal cancer Supervisor(s): Dr Paul Burton PROJECTS AVAILABLE: Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Point of care, AI-assisted, diabetic retinopathy screening in pregnant women with diabetes. Comparative outcomes of sleeve gastrectomy and Supervisor(s): Adj Clin Assoc Prof Anthony Hall adjustable gastric banding Email: [email protected] Supervisor(s): Dr Paul Burton Applicable for: Masters by coursework, Email: [email protected] BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons) Provision of burn care in the setting of COVID-19 pandemic Outcomes of major bariatric surgical procedures Supervisor(s): Dr Cheng Hean Lo Supervisor(s): Dr Paul Burton Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons)
Role of stem cells in skin tissue engineering The role of oesophageal manometry in Upper GI Supervisor(s): Dr Cheng Hean Lo surgery Email: [email protected] Supervisor(s): Dr Paul Burton Applicable for: MSc, Hons, BMedSc(Hons) Email: [email protected] The efficacy and safety of UVC disinfection in Applicable for: PhD, MSc, Hons, BMedSc(Hons) decreasing hospital acquired infections in a tertiary Investigating the use of Lectins for epidermal stem trauma centre and state adult burns centre and progenitor cells enrichment Supervisor(s): Dr Cheng Hean Lo Supervisor(s): Dr Shiva Akbarzadeh and Assoc Prof Email: [email protected] Heather Cleland Applicable for: Masters by coursework, Email: [email protected] BMedSc(Hons), Short projects
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Trend in different contraception methods among Melbourne Sexual Health women in Melbourne Supervisor(s): Assoc Prof Eric Chow, Prof Centre (MSHC) Christopher Fairley and Dr Tiffany Phillips Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons), Short projects
Human papillomavirus vaccination course completion rate among young men who have sex with men from the time-limited HPV catch-up program in Victoria Supervisor(s): Assoc Prof Eric Chow and Prof Christopher Fairley Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons), Short projects
Switching from routine presumptive treatment to presumptive treatment only if indicated for individuals reporting sexual contact with partners with Prof Christopher Fairley with colleagues. gonorrhoea Supervisor(s): Assoc Prof Eric Chow and Prof Marcus The Melbourne Sexual Health Centre (MSHC) is a Chen specialised unit for the prevention, diagnosis, Email: [email protected] treatment and management of sexually transmissible Applicable for: MSc, Hons, BMedSc(Hons), Short infections (STIs, including HIV). It is a principal centre projects for training health professionals in Victoria. The Centre conducts epidemiological, public health, and Trends in sexual practices among heterosexual men attending the Melbourne Sexual Health Centre, 2011- clinical research primarily aimed at improving the 2019 services offered at MSHC and to advance standards Supervisor(s): Assoc Prof Eric Chow and Prof of sexual health in the community. Christopher Fairley and Dr Tiffany Phillips See more: Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons), Short • www.monash.edu/medicine/ccs/sexual-health projects • www.mshc.org.au Using HPV serology to estimate the threshold for probable vaccine-induced seropositive and probable PROJECTS AVAILABLE: natural infection Sexual and reproductive health ; Genital microbiome Supervisor(s): Assoc Prof Eric Chow and Prof Marcus Supervisor(s): Prof Catriona Bradshaw, Dr Lenka Chen Vodstrcil Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons), Short Applicable for: PhD, Masters by coursework, Hons, projects BMedSc(Hons), Short projects Improving women's reproductive and sexual health Studies to improve treatment and control of Supervisor(s): Dr Lenka Vodstrcil and Prof Catriona Mycoplasma genitalium Bradshaw Supervisor(s): Prof Catriona Bradshaw, Dr Lenka Email: [email protected] Vodstrcil Applicable for: Masters by coursework, Hons, Email: [email protected] BMedSc(Hons) Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons), Short projects Health Research in Sex Workers (HERS) case-control Supervisor(s): Dr Tiffany Phillips, Prof Christopher Novel approaches to diagnosing and controlling Fairley and Assoc Prof Eric Chow bacterial sexually transmitted infections Email: [email protected] Supervisor(s): Assoc Prof Eric Chow, Assoc Prof Applicable for: Masters by coursework, Hons, Marcus Chen and Prof Christopher Fairley BMedSc(Hons), Joint PhD/Exchange Program Email: [email protected]
Applicable for: PhD, Masters by coursework, Hons, BMedSc(Hons)
| 25 Annual Sexual Practices and Activities Survey (ASAP) Supervisor(s): Dr Tiffany Phillips, Prof Christopher Fairley and Assoc Prof Eric Chow Email: [email protected] Applicable for: Masters by coursework, Hons, BMedSc(Hons), Short projects, Joint PhD/Exchange Program
Research in Male Sex Workers Supervisor(s): Dr Tiffany Phillips, Assoc Prof Eric Chow and Prof Christopher Fairley Email: [email protected] Applicable for: Masters by coursework, Hons, BMedSc(Hons)
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Central Clinical School
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Monash University reserves the right to alter information, procedures, fees and regulations contained in this document. Please check the Monash University website for updates (www.monash.edu). All information reflects prescriptions, policy and practice in force at time of publication. CRICOS Provider: Monash University 00008C Published May 2021.