DOCSLIB.ORG

Honours and Graduate Research 2022 Projects Central Clinical School

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Honours and Graduate Research 2022 Projects Central Clinical School MONASH MEDICINE, NURSING AND HEALTH SCIENCES HONOURS AND GRADUATE RESEARCH 2022 PROJECTS CENTRAL CLINICAL SCHOOL A partnership between: monash.edu/medicine/ccs Contents Honours and Graduate Research study through the Central Clinical School 2 How to use this index booklet 2 Australian Centre for Blood Diseases (ACBD) 4 Baker Heart and Diabetes Institute 6 Burnet Institute 8 Department of Allergy, Immunology and Respiratory Medicine (AIRMed) 9 Department of Diabetes 10 Department of Gastroenterology 12 Department of Immunology and Pathology 13 Department of Infectious Diseases 15 Department of Medicine (Alfred) 16 Department of Medicine (Peninsula) 17 Department of Neuroscience 18 Department of Psychiatry (MAPrc and Epworth ECIMH) 23 Department of Surgery 24 Melbourne Sexual Health Centre (MSHC) 25 Cover: Monash medical students at a diabetes workshop on the Alfred Research Alliance site Honours and Graduate Research study through the Central Clinical School Monash University’s Central Clinical School (CCS) undertakes translational research – developing insights from laboratory bench research for use in clinical therapies and treatments. Our departments and research affiliates have strong links with health care providers, ensuring that our research rapidly translates to clinical practice. booklet Undertaking Honours and postgraduate study with us will give you a wide range of opportunities to continue your studies and develop your career path This index booklet lists the Honours/PhD projects on offer into many areas of medical and clinical research. for 2016. For further information about a particular research project, see the project Projects are listed under the How to use this index booklet For information regarding description in the online following headings: This index booklet lists the Honours and postgraduate database at: Honours/Masters/PhD projects on offer study at CCS http://studentresearchprojects.m • Australian Centre for Blood for 2022. For further information about ed.monash.edu.au/. Diseases (ACBD) a particular research project, see the CCS General Honours For further information regarding project description in the online Coordinators individual research projects, • Baker Institute database at: students should approach the A/Prof Christoph Hagemeyer (Human supervisorconnect.med.monash.ed Pathology) nominated researcher • Burnet Institute u/research-projects E: [email protected] associated with that project. • Department of Allergy, For further information regarding A/Prof Margaret Hibbs (Immunology) Immunology and individual research projects, students E: [email protected] Respiratory Medicine should approach the nominated Dr Vilija Jokubaitis (Neuroscience) (AIRMed) researcher associated with that project. This booklet is meant as a guide only, E: [email protected] as project ideas will be refined between • Department of Diabetes student and supervisor. • Department of CCS BMedSc(Hons) Gastroenterology Making your application Coordinators Prof Karin Jandeleit-Dahm Applications are completed centrally • Department of Immunology E: [email protected] and Pathology through Monash University. Prospective applicants should Prof Merlin Thomas • Department of Infectious complete an application form, which E: [email protected] Diseases can be downloaded or obtained from the Faculty Office. For general information • Department of Medicine https://www.monash.edu/study/how-to- (Alfred) apply regarding Honours and postgraduate study at CCS • Department of Medicine Further information links and entry requirements: (Peninsula) Dr Joanne Mouser BMedSc(Hons) at CCS: CCS Honours Student Services • Department of E: [email protected] Neuroscience https://www.monash.edu/medicine/ccs/ P: 9903 0784 education/future-students/bmedsc- honours • Dept of Psychiatry (MAPrc Ms Sharmila Ramesh and Epworth ECIMH) Honours in Immunology & Human CCS Graduate Research Student Pathology: Services • Department of Surgery E: [email protected] https://www.monash.edu/medicine/ccs/ P: 9903 0368 • Melbourne Sexual Health education/future-students/honours Centre (MSHC) Scholarships: https://www.monash.edu/study/fees- scholarships/scholarships Masters, Doctoral, Graduate Certificate, Diploma in Clinical Research and Translational Medicine: https://www.monash.edu/medicine/ccs/ translational/about 2 | Career pathways in medical and clinical research at the Central Clinical School The Central Clincal School accepts Undergraduate applications in both the Bachelor of Medical Science (BMedSc) and General (Bachelor of Biomedical Science and Bachelor of Science) Honours streams. Graduate research project applications accepted include both Doctoral (PhD) and Masters (Master of Clinical Research – Translational Medicine stream, Master in Biomedical Science, Master in Biostatistics, or Master of Biomedical and Health Sciences) applications, as well as Graduate Diploma (Grad Dip) and Graduate Certificate (Grad Cert) applications. Short projects in Translational Research are also available. As our medical and translational research streams are taught by experts based in Monash’s rich network of educators, researchers as well as industry and clinical partnerships, this will provide excellent foundations and networks for future career pathways. This booklet lists current projects available for a number of streams at the Central Clinical School. | 3 Australian Centre for Blood Understanding how epigenetic regulation of DNA methylation leads to blood cancers Diseases (ACBD) Supervisor(s): Prof Andrew Perkins and Dr Jessica Salmon Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Genetic modelling of Acute Erythroleukaemia Supervisor(s): Dr Catherine Carmichael Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Grad Dip Therapeutic targeting of EMT modulators in cancer Supervisor(s): Dr Catherine Carmichael Email: [email protected] Applicable for: Masters by coursework, Hons, Associate Professor Christoph Hagemeyer (centre back row) and BMedSc(Hons) his group conduct novel nanoparticle research. Glucose responsive insulin nanoparticle for the The Australian Centre for Blood Diseases (ACBD) treatment of diabetes has many research groups investigating blood Supervisor(s): Assoc Prof Christoph Hagemeyer, cancers, thrombosis, and bleeding disorders. Dr Rong Xu and Assoc Prof Francesca Cavalieri ACBD is an international blood diseases centre with (External) recognised research, treatment, and educational Email: [email protected] programs for blood diseases. ACBD is affiliated with Applicable for: MSc, Hons, BMedSc(Hons), Short Monash University, Alfred Health, Eastern Health and projects Southern Health, and is organised into three integrated divisions: Recombinant agents for efficient and safe anticoagulation and thrombolysis • Clinical and Diagnostic Supervisor(s): Assoc Prof Christoph Hagemeyer and Haematology/Oncology Dr Be'eri Niego • Clinical and Basic Research Programs Email: [email protected] • Teaching and Education Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects The ACBD’s research falls into two main areas, Non- Malignant Haematology, and Malignant Haematology Single-chain antibody-targeted nanoparticles for & Stem Cell Transplantation. diagnosis of vascular diseases Supervisor(s): Assoc Prof Christoph Hagemeyer and See more: Dr Be'eri Niego www.monash.edu/medicine/ccs/blood-disease Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short projects PROJECTS AVAILABLE: Targeted virus particles for genetic transfer of fusion Analysing new targets of JAK-STAT signalling in proteins to inhibit atherosclerosis normal blood development and blood cancers Supervisor(s): Assoc Prof Christoph Hagemeyer and Supervisor(s): Prof Andrew Perkins and Dr Assoc Prof Paul Gregorevic Jessica Salmon Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons), Applicable for: PhD, MSc, Hons, BMedSc(Hons) Short projects Reprograming differentiated adult cells into Targeted exosomes for the treatment of hematopoietic stem cells atherosclerosis, myocardial infarction and stroke Supervisor(s): Prof Andrew Perkins and Dr Supervisor(s): Assoc Prof Christoph Hagemeyer and Jessica Salmon Dr Rong Xu Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons), Short project Genomics and Pre-clinical Models of Erythroleukaemia Supervisor(s): Prof Andrew Perkins and Catherine Carmichael Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons) 4 | Defining the role of Klf3 in immune activation and Novel immunosuppressive mechanisms of CTLA4 inflammation and CTLA4-Ig therapies Supervisor(s): Dr Jess Salmon and Prof Andrew Supervisor(s): Assoc Prof Ross Dickins and Dr Ethan Perkins Oxley Email: [email protected] Email: [email protected] Applicable for: MSc, Hons, BMedSc(Hons) Applicable for: PhD, MSc, Hons, BMedSc(Hons) Targeting Endothelial Cells to Treat End Organ Acute myeloid leukaemia differentiation therapy Damage caused by Graft vs Host Disease response and relapse Supervisor(s): Dr Maithili Sashindranath and Prof Supervisor(s): Assoc Prof Ross Dickins and Dr Harshal Nandurkar Steven Ngo Email: [email protected] Email: [email protected] Applicable for: PhD, MSc, Hons, BMedSc(Hons),
Load more

Recommended publications
  • Gender Equity Post-COVID-19
    ISeptembermmunology 2020 | ISSN 1356-5559 (print) News Gender equity post-COVID-19: coordinating our efforts to preserve diversity UK Coronavirus The UK Our first fully Immunology Immunological Open Access Consortium: Toolbox: journal Immunotherapy bringing immunology a hub for veterinary www.immunology.org together immunological reagents Advances 2 ADVERTISEMENTS 1 CytoFLEX, Kaluza and Duraclone are for research use only. Not for diagnostic purposes. All other products identifi ed are not for use in diagnostic procedures. The CytoFLEX, MET ONE 3400, PAT700, Multisizer 4e, Vi-CELL XR, Vi-CELL MetaFLEX, and Kaluza are designed to support GMP compliance. The Multisizer 4e, Vi-CELL XR, and Vi-CELL MetaFLEX are for Laboratory Use Only. © 2018 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. T-Cell_Anzeige_190x129mm_2.indd 1 26.03.20 11:59 Known for quality and reliability, InvivoGen provides cutting-edge tools Take your research to the research community worldwide to the next level InvivoGen’s innovative products: TLRs & innate immunity PRR ligands Reporter cell lines Inhibitors Antibodies & vaccination Mycoplasma detection & elimination Selective antibiotics COVID-19 Cloning and expression vectors Genes and promoters Custom services More information: www.invivogen.com Immunology News | September 2020 A WORD FROM THE EDITOR 3 ©©Shutterstock/howcolour Welcome to the autumn issue of Immunology This new issue also features an overview of News. Here, we look back at what we’ve been the impact of COVID-19 on gender inequity. doing to continue supporting our members Members from the Australian and New and feeding into public discussion around Zealand Society for Immunology provide COVID-19, including our three webinar a perspective from Societies, EMCRs and series and our new infographics on PCR educators, and how we can plan for the future.
    [Show full text]
  • Editorial: the Role of Innate Lymphoid Cells in Mucosal Immunity
    EDITORIAL published: 17 June 2020 doi: 10.3389/fimmu.2020.01233 Editorial: The Role of Innate Lymphoid Cells in Mucosal Immunity Jessica G. Borger 1*†, Graham Le Gros 2† and Joanna R. Kirman 3† 1 Department of Immunology and Pathology, Central Clinical School, Monash University, Alfred Research Alliance, Melbourne, VIC, Australia, 2 Allergic & Parasitic Diseases Programme, Malaghan Institute of Medical Research, Wellington, New Zealand, 3 Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand Keywords: ILC, NK cell, mucosal, immunity, lung, gastrointestinal tract, genitourinary tract Editorial on the Research Topic The Role of Innate Lymphoid Cells in Mucosal Immunity Innate Lymphoid Cells (ILCs) are tissue-resident innate cells that are deeply integrated within mucosal tissues and play a critical role in tissue homeostasis and inflammatory processes. The collection of articles in this Frontiers Research Topic investigates and discusses the new and emerging roles of ILCs in mucosal immunity. The field of ILC biology has increased exponentially in recent years. Although the scientific Edited and reviewed by: community had been aware of the existence of certain innate cells of lymphoid origin for many Marina Cella, Washington University School of years, it has only been in the past decade that the full extent of the ILC family and their Medicine in St. Louis, United States wide-reaching biological roles has been recognized. As the field expanded, to avoid confusion due to the different names being used in the literature for the same ILC subsets, in 2013 it was *Correspondence: Jessica G. Borger proposed that ILCs should be divided into three broad lineages based on specific transcription [email protected] factor expression and the cytokines they produce.
    [Show full text]
  • EMJ-Respiratory-8.1-2020-1.Pdf
    RESPIRATORY European Edition Vol. 8.1 November 2020 emjreviews.com + ERS INTERNATIONAL CONGRESS 2020 + EDITOR’S PICK + INTERVIEWS Two ERS 2020 Award Winners Improving Antenatal provide fascinating insights into their area of expertise in Asthma Management: cardiopulmonary rehabilitation A Complex Journey and intensive care medicine. + ABSTRACT REVIEWS Captivating reviews of abstracts presented at ERS International Congress 2020. WELCOME TO THE BREATHING HOTSPOT. Visit www.wehale.life/hcp GO TO DESTINATION FOR HEALTHCARE PROFESSIONALS WORKING WITH ASTHMA AND COPD • Patient support materials • Instruction and tutorial videos • Information about the Easyhaler® product family ENTER CHECK THE LATEST SCIENTIFIC INSIGHTS Terapia wziewna – ze szczególnym uwzględnieniem steroidów – w okresie pandemii COVID-19. Scientific Presentations at Virtual ERS Congress 2020 Performance under simulated www.wehale.life/de/Corona/ Sponsored by Orion Pharma. real-life conditions. Cercano al inhalador ideal: fácil y conveniente. (NL) Switching asthma and COPD patients to Easyhaler® Potilaiden tyytyväisyys inhalaattoriin Costs of switching to low global warming leads to improved clinical outcomes and QOL. on yhteydessä parempaan hoitomyönty- potential inhalers. UK Prescribing Information (FR) Pharmacokinetics of salmeterol and fluticasone vyyteen ja astman hoitotasapainoon. propionate delivered in combination via Easyhaler® Evaluation of the efficiency of single-inhaler and Diskus® dry powder inhalers. combination therapy with budesonide/ Adverse events should
    [Show full text]
  • Type 3 Ilcs in Lung Disease
    REVIEW published: 29 January 2019 doi: 10.3389/fimmu.2019.00092 Type 3 ILCs in Lung Disease Amanda Ardain 1,2, James Zachary Porterfield 1,2,3, Henrik N. Kløverpris 1,4,5 and Alasdair Leslie 1,5* 1 Africa Health Research Institute, Durban, South Africa, 2 College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa, 3 Yale School of Public Health, Yale University, New Haven, CT, United States, 4 Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, 5 Department of Infection and Immunity, University College London, London, United Kingdom The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects. Keywords: ILC3, lung disease, pnemonia, tuberulosis, COPD, airway hypersensitivity, pulmonary fibrosis Edited by: Jessica Borger, Monash University, Australia INTRODUCTION Reviewed by: The lungs are complex organs, the proper functioning of which is essential for good health, William Garrow Kerr, but whose exposure to the external environment renders them susceptible to infections and Upstate Medical University, United States environmental toxins.
    [Show full text]
  • GSH-C4 Acts As Anti-Inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through Nfκb Inhibition
    ORIGINAL RESEARCH published: 06 February 2019 doi: 10.3389/fimmu.2019.00155 GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition Dolores Limongi 1†, Sara Baldelli 1†, Paola Checconi 1, Mariaelena Marcocci 2, Giovanna De Chiara 3, Alessandra Fraternale 4, Mauro Magnani 4, Maria Rosa Ciriolo 5,6* and Anna Teresa Palamara 6,7* 1 Department of Human Sciences and Promotion of the Quality of Life, IRCCS San Raffaele Pisana, San Raffaele Roma Open University, Rome, Italy, 2 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy, 3 Institute of Translational Pharmacology, National Research Council Rome, Rome, Italy, 4 University of Urbino Carlo Bo, Department of Biomolecular Sciences, Urbino, Italy, 5 Department of Biology, University of Rome “Tor Vergata”, Rome, Italy, 6 7 Edited by: IRCCS San Raffaele Pisana, Rome, Italy, Institute Pasteur-Fondazione Cenci Bolognetti, Rome, Italy Stefano Caserta, University of Hull, United Kingdom An imbalance in GSH/GSSG ratio represents a triggering event in pro-inflammatory Reviewed by: cytokine production and inflammatory response. However, the molecular mechanism(s) Valerio Chiurchiù, Campus Bio-Medico University, Italy through which GSH regulates macrophage and cell autonomous inflammation remains Jessica Borger, not deeply understood. Here, we investigated the effects of a derivative of GSH, the Monash University, Australia N-butanoyl glutathione (GSH-C4), a cell permeable compound, on lipopolisaccharide *Correspondence: Maria Rosa Ciriolo (LPS)-stimulated murine RAW 264.7 macrophages, and human macrophages. LPS [email protected] alone induces a significant production of pro-inflammatory cytokines, such as IL-1β, Anna Teresa Palamara IL-6, and TNF-α and a significant decrement of GSH content.
    [Show full text]
  • Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury
    UCSF UC San Francisco Previously Published Works Title Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia- Reperfusion Injury. Permalink https://escholarship.org/uc/item/9pb8c94q Authors Cameron, Guy JM Cautivo, Kelly M Loering, Svenja et al. Publication Date 2019 DOI 10.3389/fimmu.2019.00826 Peer reviewed eScholarship.org Powered by the California Digital Library University of California ORIGINAL RESEARCH published: 16 April 2019 doi: 10.3389/fimmu.2019.00826 Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury Guy J. M. Cameron 1,2, Kelly M. Cautivo 3, Svenja Loering 1,2, Simon H. Jiang 4,5, Aniruddh V. Deshpande 1,2,6, Paul S. Foster 1,2, Andrew N. J. McKenzie 7, Ari B. Molofsky 3, Philip M. Hansbro 1,2,8,9 and Malcolm R. Starkey 1,2* 1 Priority Research Centre’s GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia, 2 Hunter Medical Research Institute, New Lambton Heights, NSW, Australia, 3 Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States, 4 Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australia National University, Canberra, ACT, Australia, 5 Department of Renal Medicine, The Canberra Hospital, Canberra, ACT, Australia, 6 The John Hunter Children’s Hospital, New Lambton Heights, NSW, Australia, 7 MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, United Kingdom, 8 Centre for inflammation, Centenary Institute, Sydney, NSW, Australia, 9 Faculty of Science, University of Technology, Ultimo, NSW, Australia Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease.
    [Show full text]
  • Contact Us Derrick Rowley Medal Asi Honours Susanne
    ASI NEWS MARCH 2020 CONTACT US 10 26 AUSTRALIAN AND NEW ZEALAND SOCIETY FOR DERRICK ROWLEY MEDAL VISIT FROM PROF. IMMUNOLOGY INC. ASI HONOURS SUSANNE STEVEN ALBELDA ASI INC. SECRETARIAT HEINZEL AND ALAN BAXTER FROM UNIVERSITY OF PO BOX 1371, PENNSYLVANIA MITCHAM NORTH 3132 CONNIE JACKAMAN PH: 03 8393 9388 ALEC REDWOOD immunology.org.au/contact-us CONTENTS ASI NEWSLETTER MARCH 2020 CONTENTS PRESIDENT’S COLUMN ....................................... 3 SPECIAL INTEREST GROUP NEWS ..................20 John Fraser Helen McGuire A COUNTRY, A COMMUNITY NOOSA THROUGH THE MUCOSA AND BURNING BRIGHT ................................................ 4 MICROBIOME .....................................................21 Angelica Lau Jonatan Leffler ASI MEETING HIGHLIGHTS.................................. 5 LET’S TALK ABOUT EDUCATION IN IMMUNOLOGY ................................................... 23 HELLO FROM YOUR NEW Samy Sakkal HON. SECRETARY ................................................ 7 Connie Jackaman UPCOMING VISITING SPEAKERS IN 2020 ...... 25 Stuart Mannering 2019 TREASURER’S REPORT .............................. 7 Asolina Braun PROF. STEVEN ALBELDA FROM UNIVERSITY OF PENNSYLVANIA VISITS ASI COMMUNITY ....... 26 CTI SPECIAL FEATURES ...................................... 8 Alec Redwood DERRICK ROWLEY MEDAL HONORS ITA - 2019 ASI ANNUAL MEETING, ADELAIDE, SUSANNE HEINZEL & ALAN BAXTER ...............10 AUSTRALIA ........................................................ 28 Connie Jackaman Amania A. Sheikh THE IUIS CORNER ................................................11
    [Show full text]
  • Contact Us Hear from the Newly Formed ASI Special Interest Groups
    ASI NEWS March 2021 WIN a signed copy of ‘Pandemics’ by Nobel laureate Peter Doherty 6 Find out the ways ASI is helping to keep you connected 11 26 Contact Us Australian and New Zealand Hear from the newly Launch of the Clinical Society for Immunology Inc. formed ASI Special & Translational ASI Inc. Secretariat Interest Groups Immunology COVID-19 PO Box 1371, Mitcham North 3132 Fernando Fonseca Guimaraes collection Ph: 03 8393 9388 immunology.org.au/contact-us Contents ASI Newsletter March 2021 Contents HELLO AND WELCOME TO 2021 ...................................................................................................................................................................3 Debbie Burnett SECRETARY REPORT ........................................................................................................................................................................................4 Connie Jackaman TREASURER’S REPORT ....................................................................................................................................................................................5 Asolina Braun WIN YOUR OWN AUTOGRAPHED COPY OF PETER DOHERTY’S BOOK, “PANDEMICS” .................................................................6 Immunology & Cell Biology and Clinical & Translational Immunity ASI ADVANCED IMMUNOLOGY SCHOOL ....................................................................................................................................................7 AIS Organising Committee A MESSAGE
    [Show full text]
  • ILC2 Orchestration of Local Immune Function in Adipose Tissue
    Edinburgh Research Explorer ILC2 orchestration of local immune function 1 in adipose tissue Citation for published version: Benezech, C & Jackson-Jones, L 2019, 'ILC2 orchestration of local immune function 1 in adipose tissue', Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.00171 Digital Object Identifier (DOI): 10.3389/fimmu.2019.00171 Link: Link to publication record in Edinburgh Research Explorer Document Version: Publisher's PDF, also known as Version of record Published In: Frontiers in Immunology General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 04. Oct. 2021 MINI REVIEW published: 07 February 2019 doi: 10.3389/fimmu.2019.00171 ILC2 Orchestration of Local Immune Function in Adipose Tissue Cécile Bénézech 1* and Lucy Helen Jackson-Jones 2* 1 BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, 2 Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom ILC2s were originally identified as IL-5 and IL-13 secreting “natural helper cells” present within the fat-associated lymphoid clusters of the mesenteries in both mouse and man.
    [Show full text]
  • Young Investigator Symposium Series 2020 PRELIMINARY PROGRAM – SUBJECT to CHANGE
    Young Investigator Symposium Series 2020 PRELIMINARY PROGRAM – SUBJECT TO CHANGE Young Investigator Symposium Series 2020 FRIDAY 2 OCTOBER - PRELIMINARY PROGRAM – SUBJECT TO CHANGE www.viin.org.au #viinyis Young Investigator Symposium Series 2020 PRELIMINARY PROGRAM – SUBJECT TO CHANGE Program-at-a-Glance 2020 Monday 12 October: 10am – 12.45pm Keynote speaker: Associate Professor Kimberley Kline, Nanyang Technological University, Singapore Talks selected from abstracts Technical workshop Daily prize announcement Tuesday 13 October: 10am – 12pm Grant writing workshop and Q&A • Dr Sant-Rayn Pasricha, Walter and Eliza Hall Institute • Dr Sally Roberts, veski • Associate Professor Meredith O’Keeffe, Monash University and ARC College of Experts • Associate Professor Michelle Tate, Hudson Institute of Medical Research and NHMRC Career Development Fellow • Professor James Beeson, Burnet Institute Tuesday 13 October: 1pm – 2.30pm Concurrent E-poster sessions (I and II) Tuesday 13 October: 7pm – 8.15pm Art in Science evening • Marta de Menezes • Science Gallery Melbourne Wednesday 14 October: 10am – 12pm Careers panel and Q&A • Dr Krystal Evans • Dr Jessica Borger • Dr Michael Christie • Dr Stephanie Tan • Dr Ariel Achtman Wednesday 14 October: 1pm – 2.30pm Concurrent E-poster sessions (III and IV) Thursday 15 October: 10am – 12.45pm Keynote speaker: Dr Amy Chung, Peter Doherty Institute of Infection and Immunity, University of Melbourne Talks selected from abstracts Technical workshop Daily prize announcement Friday 16 October: 10am – 1pm Keynote
    [Show full text]
  • Peripheral Innate Lymphoid Cells Are Increased in First Line Metastatic Colorectal Carcinoma Patients
    ORIGINAL RESEARCH published: 06 September 2019 doi: 10.3389/fimmu.2019.02121 Peripheral Innate Lymphoid Cells Are Edited by: Jessica Borger, Increased in First Line Metastatic Monash University, Australia Reviewed by: Colorectal Carcinoma Patients: A Ennio Carbone, Università degli studi Magna Græcia di Negative Correlation With Th1 Catanzaro, Italy Anja Fuchs, Immune Responses Washington University in St. Louis, United States Romain Loyon 1†, Marine Jary 2,3,4, Bérengère Salomé 1†, Alejandra Gomez-Cadena 1, *Correspondence: Jeanne Galaine 2, Marie Kroemer 2,5, Pedro Romero 1, Sara Trabanelli 1, Olivier Adotévi 2,3, Camilla Jandus Christophe Borg 2,3 and Camilla Jandus 1* [email protected] 1 Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, †Present address: Lausanne, Switzerland, 2 Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Romain Loyon, Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Besançon, France, 3 Department of Medical Oncology, University Univ. Bourgogne Franche-Comté, Hospital of Besançon, Besançon, France, 4 INSERM CIC-1431, Clinical Investigation Center in Biotherapy, University Hospital INSERM, EFS BFC, UMR1098, of Besançon, Besançon, France, 5 Department of Pharmacy, University Hospital of Besançon, Besançon, France Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Besançon, Several distinct innate lymphoid cell (ILC) populations have been recently identified and France; Department of Medical Oncology, University Hospital of shown to play a critical role in the immediate immune defense. In the context of tumors, Besançon, Besançon, France there is evidence to support a dual role for ILCs with pro- or antitumor effects, depending Bérengère Salomé, on the ILC subset and the type of cancer.
    [Show full text]
  • Innate Lymphoid Cells in Helminth Infections—Obligatory Or Accessory?
    REVIEW published: 10 April 2019 doi: 10.3389/fimmu.2019.00620 Innate Lymphoid Cells in Helminth Infections—Obligatory or Accessory? Stephan Löser 1, Katherine A. Smith 2,3 and Rick M. Maizels 1* 1 Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2 Cardiff Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 3 Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa ILCs burst onto the immunological scene with their involvement in bacterial and helminth infections. As their influence has emerged, it has become clear that they play a fundamental role in regulating barrier tissue homeostasis and the immune response during inflammation. A subset of ILCs, ILC2s, has become the focus of attention for many helminth biologists—stepping into the limelight as both the elusive initiator and amplifier of the type-2 response. In many of the early reports, conclusions as to their function were based on experiments using unadapted parasites or immune-compromised hosts. In this review we re-examine the generation and function of type-2 ILCs in helminth infection and the extent to which their roles may be essential or redundant, in both primary and challenge infections. ILC2s will be discussed in terms of a broader innate network, which when in dialogue with adaptive immunity, allows the generation of the anti-parasite response. Finally, we will review how helminths manipulate ILC2 populations Edited by: Jessica Borger, to benefit their survival, as well as dampen systemic inflammation in the host, and how Monash University, Australia this understanding may be used to improve strategies to control disease.
    [Show full text]