Contents Volume 62 Issue 7 | July 2013

Commentaries Coeliac disease 955 Early diagnosis of pancreatic cancer; looking for 996 Kinetics of the histological, serological and a needle in a haystack? symptomatic responses to gluten challenge in M J Bruno adults with coeliac disease D Leffl er, D Schuppan, K Pallav, R Najarian,

957 Dissecting the role of CB1 receptors on chronic J D Goldsmith, J Hansen, T Kabbani, M Dennis, Gut: first published as on 1 July 2013. Downloaded from Caption: Computer artwork of pancreatic cancer. See C P Kelly in this issue two articles on detection of pancreatic liver diseases cysts and pancreatic cancer and its precursors. Gut R Bataller, B Gao is committed to advancing knowledge in the field Colon of pancreatic cancer, a malignancy with the worst prognosis of all GI cancers. 959 Looking beyond histological healing in ulcerative 1005 Risk adjusted benchmarking of Credit: Sciepro/Science Photo Library. colitis: towards the establishment of a molecular abdominoperineal excision for rectal signature for quiescent but progressive disease adenocarcinoma in the context of the Belgian PROCARE improvement project An international journal of M Chamaillard, J-B Chevaux, L Peyrin-Biroulet gastroenterology and hepatology F Penninckx, S Fieuws, K Beirens, P Demetter, : 10.111 W Ceelen, A Kartheuser, G Molle, J Van de Stadt, Editor Original articles K Vindevoghel, E Van Eycken, on behalf of Emad El-Omar (UK) Upper GI cancer PROCARE Deputy Editor (Hepatology) 961 Hospital volume, proportion resected and Alexander Gerbes (Germany) mortality from oesophageal and gastric 1012 In situ validation of an intestinal stem cell Deputy Editor (Luminal cancer: a population-based study in , Gastroenterology) signature in colorectal cancer 2004–2008 William Grady (USA) J L Ziskin, D Dunlap, M Yaylaoglu, I K Fodor, Deputy Editor (Endoscopy) V H Coupland, J Lagergren, M Lüchtenborg, W F Forrest, R Patel, N Ge, G G Hutchins, J K Pine, Thomas Roesch (Germany) R H Jack, W Allum, L Holmberg, G B Hanna, P Quirke, H Koeppen, A M Jubb Associate Editors N Pearce, H Møller Matias Avila (Spain) Guy Boeckxstaens (Belguim) Pancreas

Laurence Egan (Ireland) Infl ammatory bowel disease 1024 Mutant GNAS detected in duodenal collections http://gut.bmj.com/ Thomas Gress (Germany) 967 Transcriptional analysis of the intestinal mucosa of secretin-stimulated pancreatic juice indicates Ernst Kuipers (The Netherlands) of patients with ulcerative colitis in remission the presence or emergence of pancreatic cysts Julian Panes (Spain) reveals lasting epithelial cell alterations Herbert Tilg (Austria) M Kanda, S Knight, M Topazian, S Syngal, Fabien Zoulim (France) N Planell, J J Lozano, R Mora-Buch, J Farrell, J Lee, I Kamel, A M Lennon, M Borges, M C Masamunt, M Jimeno, I Ordás, M Esteller, Editorial Offi ce A Young, S Fujiwara, J Seike, J Eshleman, Gut E Ricart, J M Piqué, J Panés, A Salas R H Hruban, M I Canto, M Goggins

BMJ Journals on September 29, 2021 by guest. Protected copyright. BMA House, Tavistock Square Next generation exome sequencing of paediatric London, WC1H 9JR, UK 977 1034 Claudin-4-targeted optical imaging detects T: +44 (0)20 7383 6394 infl ammatory bowel disease patients identifi es pancreatic cancer and its precursor lesions F: +44 (0)20 7383 6668 rare and novel variants in candidate genes A Neesse, A Hahnenkamp, H Griesmann, E: [email protected] K Christodoulou, A E Wiskin, J Gibson, W Tapper, M Buchholz, S A Hahn, A Maghnouj, V Fendrich, ISSN: 0017-5749 (print) C Willis, N A Afzal, R Upstill-Goddard, ISSN: 1468-3288 (online) J Ring, B Sipos, D A Tuveson, C Bremer, T M Gress, J W Holloway, M A Simpson, R M Beattie, P Michl Disclaimer: Gut is owned and published by BMJ A Collins, S Ennis Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association and the British Society of Gastroenterology. The owners grant editorial freedom to the Editor of Gut. Gut follows Neurogastroenterology guidelines on editorial independence produced by 985 Identifying and testing candidate genetic the World Association of Medical Editors and the code on good publication practice of the polymorphisms in the irritable bowel syndrome MORE CONTENTS ᭤ Committee on Publication Ethics. (IBS): association with TNFSF15 and TNF␣ Gut is intended for medical professionals and is provided without warranty, express or implied. C Swan, N P Duroudier, E Campbell, A Zaitoun, Statements in the Journal are the responsibility This article has been chosen by the Editor to be of special interest of their authors and advertisers and not authors’ M Hastings, G E Dukes, J Cox, F M Kelly, J Wilde, or importance and is freely available online. institutions, the BMJ Publishing Group, the British M G Lennon, K R Neal, P J Whorwell, I P Hall, Society of Gastroenterology or the BMA unless This article has been made freely available online under the BMJ otherwise specifi ed or determined by law. R C Spiller Acceptance of advertising does not imply Journals Open Access scheme. endorsement. OPEN ACCESS See http://gut.bmj.com/site/about/guidelines.xhtml#open To the fullest extent permitted by law, the BMJ Publishing Group shall not be liable for any loss, injury or damage resulting from the use of Gut or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on. This journal is a member of and subscribes to the principles of the Copyright © 2013 BMJ Publishing Group Ltd and Committee on Publication Ethics British Society of Gastroenterology. All rights reserved; no part of this publication may be www.publicationethics.org.uk reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without prior permission Gut is published by BMJ Publishing Group Ltd, typeset by Techset and printed in the UK on acid-free paper. Gut (ISSN: 0017-5749) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Gut, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA.

gutjnl_62_7_TOC.indd 1 04/06/13 12:31 PM Contents Volume 62 Issue 7 | GUT July 2013

Hepatology Recent advances in clinical practice Receive regular table of contents by email. 1044 Estrogen-related receptor ␥ controls hepatic 1072 Crohn’s disease complicated by strictures: Register using this QR code.

CB1 receptor-mediated CYP2E1 expression and a systematic review oxidative liver injury by alcohol F Rieder, E M Zimmermann, F H Remzi, D-K Kim, Y-H Kim, H-H Jang, J Park, J R Kim, W J Sandborn M Koh, W-Il Jeong, S-H Koo, T-S Park, C-H Yun, Gut: first published as on 1 July 2013. Downloaded from S B Park, J Y L Chiang, C-H Lee, H-S Choi JournalScan 1085 GI highlights from the literature 1055 Combination therapies with NS5A, NS3 and M H McLean NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice Editor ’s quiz: GI snapshot N Shi, N Hiraga, M Imamura, C N Hayes, 995 Malignant mimicry—a 17-year-old with Y Zhang, K Kosaka, A Okazaki, E Murakami, abdominal pain and weight loss M Tsuge, H Abe, H Aikata, S Takahashi, H Ochi, S Mankodi, K Planche, J Watkins, C Murray C Tateno-Mukaidani, K Yoshizato, H Matsui, A Kanai, T Inaba, F McPhee, M Gao, K Chayama PostScript 1088 Letters Recent advances in basic science 1062 Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium C Günther, H Neumann, M F Neurath, C Becker http://gut.bmj.com/ on September 29, 2021 by guest. Protected copyright.

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