Introduction to Addictive Behaviors, Fourth Edition
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Depression and Antidepressants in Australia and Beyond - a Critical Public Health Analysis Melissa Raven University of Wollongong
University of Wollongong Research Online University of Wollongong Thesis Collection University of Wollongong Thesis Collections 2012 Depression and antidepressants in Australia and beyond - a critical public health analysis Melissa Raven University of Wollongong Recommended Citation Raven, Melissa, Depression and antidepressants in Australia and beyond - a critical public health analysis, Doctor of Philosophy thesis, Faculty of Arts, University of Wollongong, 2012. http://ro.uow.edu.au/theses/3686 Research Online is the open access institutional repository for the University of Wollongong. For further information contact the UOW Library: [email protected] Depression and antidepressants in Australia and beyond A critical public health analysis A thesis submitted in fulfilment of the requirements for the award of the degree Doctor of Philosophy from UNIVERSITY OF WOLLONGONG by Melissa Raven BA(Hons), MPsych(Clin), MMedSci(ClinEpid) Faculty of Arts 2012 ii Certification I, Melissa Raven, declare that this thesis, submitted in fulfilment of the requirements for the award of Doctor of Philosophy, in the Faculty of Arts, University of Wollongong, is wholly my own work unless otherwise referenced or acknowledged. The document has not been submitted for qualifications at any other academic institution. Melissa Raven 5 July 2012 iii iv Concise table of contents List of acronyms .................................................................................... xiii Abstract .................................................................................................. -
Prevalence of Risk for Substance-Related and Behavioral Addictions Among University Students in Turkey
THE TURKISH JOURNAL ON ADDICTIONS www.addicta.com.tr ORIGINAL RESEARCH Prevalence of Risk for Substance-Related and Behavioral Addictions Among University Students in Turkey Esma Akpınar Aslan1 , Sedat Batmaz1 , Zekiye Çelikbaş1 , Oğuzhan Kılınçel2 , Gökben Hızlı Sayar3 , Hüseyin Ünübol3 1Department of Psychiatry, Tokat Gaziosmanpasa University School of Medicine, Tokat, Turkey 2Department of Child Development, İstanbul Gelişim University, İstanbul, Turkey 3Department of Psychiatry, Üsküdar University School of Medicine, İstanbul, Turkey ORCID iDs of the authors: E.A.A. 0000-0003-4714-6894; S.B. 0000-0003-0585-2184; Z.Ç. 0000-0003-4728-7304; O.K. 0000-0003-2988- 4631; G.H.S. 0000-0002-2514-5682; H.Ü. 0000-0003-4404-6062. Main Points • Men were found to be at higher risk for potential alcohol dependence, pathological gambling, gam- ing addiction, and sex/pornography addiction. • Mild nicotine addiction, problematic internet use and possible smartphone addiction, food addic- tion, and gaming addiction were higher in the age group of 18-24 years than in older students. • Screening for addiction risk in young people is crucial for effective prevention, early diagnosis, and treatment. • The screening programs and treatment targeting men and women, and different age groups need to be designed selectively. Abstract This study aims to investigate the prevalence of risk for substance-related and behavioral addictions among university students in Turkey. In total, 612 students were included in this study, and they completed an online questionnaire consisting of the Fagerström Test for Nicotine Dependence, the Alcohol Use Disorders Identifica- tion Test, the Drug Abuse Screening Test, the Smartphone Addiction Scale-Short Version, the Young’s Internet Addiction Test-Short Form, the South Oaks Gambling Screen, and the Burden of Behavioral Addiction Form. -
Concurrent Alcohol and Tobacco Dependence
Concurrent Alcohol and Tobacco Dependence Mechanisms and Treatment David J. Drobes, Ph.D. People who drink alcohol often also smoke and vice versa. Several mechanisms may contribute to concurrent alcohol and tobacco use. These mechanisms include genes that are involved in regulating certain brain chemical systems; neurobiological mechanisms, such as cross-tolerance and cross-sensitization to both drugs; conditioning mechanisms, in which cravings for alcohol or nicotine are elicited by certain environmental cues; and psychosocial factors (e.g., personality characteristics and coexisting psychiatric disorders). Treatment outcomes for patients addicted to both alcohol and nicotine are generally worse than for people addicted to only one drug, and many treatment providers do not promote smoking cessation during alcoholism treatment. Recent findings suggest, however, that concurrent treatment for both addictions may improve treatment outcomes. KEY WORDS: comorbidity; AODD (alcohol and other drug dependence); alcoholic beverage; tobacco in any form; nicotine; smoking; genetic linkage; cross-tolerance; AOD (alcohol and other drug) sensitivity; neurotransmitters; brain reward pathway; cue reactivity; social AODU (AOD use); cessation of AODU; treatment outcome; combined modality therapy; literature review lcohol consumption and tobacco ers who are dependent on nicotine Department of Health and Human use are closely linked behaviors. have a 2.7 times greater risk of becoming Services 1989). The concurrent use of A Thus, not only are people who alcohol dependent than nonsmokers both drugs by pregnant women can drink alcohol more likely to smoke (and (e.g., Breslau 1995). Finally, although also result in more severe prenatal dam- vice versa) but also people who drink the smoking rate in the general popula age and neurocognitive deficits in their larger amounts of alcohol tend to smoke tion has gradually declined over the offspring than use of either drug alone more cigarettes. -
Overdiagnosis and Overtreatment Over Time
University of Massachusetts Medical School eScholarship@UMMS Family Medicine and Community Health Publications and Presentations Family Medicine and Community Health 2015-6 Overdiagnosis and overtreatment over time Stephen A. Martin University of Massachusetts Medical School Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/fmch_articles Part of the Community Health and Preventive Medicine Commons, Diagnosis Commons, Family Medicine Commons, Preventive Medicine Commons, and the Primary Care Commons Repository Citation Martin SA, Podolsky SH, Greene JA. (2015). Overdiagnosis and overtreatment over time. Family Medicine and Community Health Publications and Presentations. https://doi.org/10.1515/dx-2014-0072. Retrieved from https://escholarship.umassmed.edu/fmch_articles/318 Creative Commons License This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Family Medicine and Community Health Publications and Presentations by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. Diagnosis 2015; 2(2): 105–109 Opinion Paper Open Access Stephen A. Martin*, Scott H. Podolsky and Jeremy A. Greene Overdiagnosis and overtreatment over time Abstract: Overdiagnosis and overtreatment are often Introduction thought of as relatively recent phenomena, influenced by a contemporary combination of technology, speciali- In recent years, an increasing number of clinicians, jour- zation, payment models, marketing, and supply-related nalists, health service researchers, and policy-makers demand. Yet a quick glance at the historical record reveals have drawn attention to the problems of overdiagnosis that physicians and medical manufacturers have been and the overtreatment that it so often engenders [1, 2]. -
Short Note on Dark Side of Addiction
lism and D OPEN ACCESS Freely available online o ru h g o lc D A e p f e o n l d a e Journal of n r n c u e o J ISSN: 2329-6488 Alcoholism & Drug Dependence Editorial Short Note on Dark Side of Addiction Richard Samson* Department of Psychology, Faculty of Pharmacy, University of Michigan, 500 S State St, Ann Arbor, MI 48109, United States ABSTRACT Addiction is a biopsychosocial disorder characterized by repeated use of drugs, or repetitive engagement in a behavior such as gambling, despite harm to self and others. According to the "brain disease model of addiction," while a number of psychosocial factors contribute to the development and maintenance of addiction, a biological process that is induced by repeated exposure to an addictive stimulus is the core pathology that drives the development and maintenance of an addiction. Many scholars who study addiction argue that the brain disease model is incomplete and misleading. Emotions are "feeling" states and classic physiological emotive responses that are interpreted based on the history of the organism and the context. Motivation is a persistent state that leads to organized activity. Both are intervening variables and intimately related and have neural representations in the brain. The present thesis is that drugs of abuse elicit powerful emotions that can be interwoven conceptually into this framework. Keywords: Allostasis; Corticotropin-releasing factor; Dynorphin; Extended amygdala; Incentive salience; Opponent process INTRODUCTION clinical research in humans and preclinical studies involving ΔFosB have identified compulsive sexual activity – specifically, any form The brain disease model posits that addiction is a disorder of the of sexual intercourse – as an addiction (i.e., sexual addiction). -
ASAM National Practice Guideline for the Treatment of Opioid Use Disorder: 2020 Focused Update
The ASAM NATIONAL The ASAM National Practice Guideline 2020 Focused Update Guideline 2020 Focused National Practice The ASAM PRACTICE GUIDELINE For the Treatment of Opioid Use Disorder 2020 Focused Update Adopted by the ASAM Board of Directors December 18, 2019. © Copyright 2020. American Society of Addiction Medicine, Inc. All rights reserved. Permission to make digital or hard copies of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for commercial, advertising or promotional purposes, and that copies bear this notice and the full citation on the fi rst page. Republication, systematic reproduction, posting in electronic form on servers, redistribution to lists, or other uses of this material, require prior specifi c written permission or license from the Society. American Society of Addiction Medicine 11400 Rockville Pike, Suite 200 Rockville, MD 20852 Phone: (301) 656-3920 Fax (301) 656-3815 E-mail: [email protected] www.asam.org CLINICAL PRACTICE GUIDELINE The ASAM National Practice Guideline for the Treatment of Opioid Use Disorder: 2020 Focused Update 2020 Focused Update Guideline Committee members Kyle Kampman, MD, Chair (alpha order): Daniel Langleben, MD Chinazo Cunningham, MD, MS, FASAM Ben Nordstrom, MD, PhD Mark J. Edlund, MD, PhD David Oslin, MD Marc Fishman, MD, DFASAM George Woody, MD Adam J. Gordon, MD, MPH, FACP, DFASAM Tricia Wright, MD, MS Hendre´e E. Jones, PhD Stephen Wyatt, DO Kyle M. Kampman, MD, FASAM, Chair 2015 ASAM Quality Improvement Council (alpha order): Daniel Langleben, MD John Femino, MD, FASAM Marjorie Meyer, MD Margaret Jarvis, MD, FASAM, Chair Sandra Springer, MD, FASAM Margaret Kotz, DO, FASAM George Woody, MD Sandrine Pirard, MD, MPH, PhD Tricia E. -
Process Addictions
Defining, Identifying and Treating Process Addictions PRESENTED BY SUSAN L. ANDERSON, LMHC, NCC, CSAT - C Definitions Process addictions – a group of disorders that are characterized by an inability to resist the urge to engage in a particular activity. Behavioral addiction is a form of addiction that involves a compulsion to repeatedly perform a rewarding non-drug-related behavior – sometimes called a natural reward – despite any negative consequences to the person's physical, mental, social, and/or financial well-being. Behavior persisting in spite of these consequences can be taken as a sign of addiction. Stein, D.J., Hollander, E., Rothbaum, B.O. (2009). Textbook of Anxiety Disorders. American Psychiatric Publishers. American Society of Addiction Medicine (ASAM) As of 2011 ASAM recognizes process addictions in its formal addiction definition: Addiction is a primary, chronic disease of pain reward, motivation, memory, and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social, and spiritual manifestations. This is reflected in an individual pathologically pursuing reward and/or relief by substance use and other behaviors. Addictive Personality? An addictive personality may be defined as a psychological setback that makes a person more susceptible to addictions. This can include anything from drug and alcohol abuse to pornography addiction, gambling addiction, Internet addiction, addiction to video games, overeating, exercise addiction, workaholism and even relationships with others (Mason, 2009). Experts describe the spectrum of behaviors designated as addictive in terms of five interrelated concepts which include: patterns habits compulsions impulse control disorders physiological addiction Such a person may switch from one addiction to another, or even sustain multiple overlapping addictions at different times (Holtzman, 2012). -
BOOKTIVISM: the Power of Words
BOOKTIVISM: The Power of Words Book•ti•vi•sm(noun). 1. The mobilization of groups of concerned citizens produced by reading books offering powerful analyses of social or political issues. 2. A call to action based on the sharing of knowledge through books. 3. Books + activism = “booktivism.” 4. A term first used at the SellingSickness, 2013: People Before Profits conference in Washington, DC, see www.sellingsickness.com. Read. Discuss. Be thoughtful. Be committed. Here are some more suggestions to get you started: 1) Set up a reading group on disease-mongering among interested friends and colleagues. If you do The books included in BOOKTIVISM celebrate recent contributions to the broad topic of disease- not already have a group of interested readers, post a notice in your workplace, library, community mongering, especially as they examine the growing prevalence and consequences of overtreatment, center, apartment building, etc. Once you have a group, decide where to meet. Book clubs can overscreening, overmarketing, and overdiagnosis (see Lynn Payer’s 1992 classic, Disease-Mongers: How meet anywhere – at homes, in dorms, in pubs, in coffeehouses, at libraries, even online! Decide on Doctors, Drug Companies, and Insurers Are Making You Feel Sick, for an introduction to timing and format. Will you meet monthly/bimonthly? You’ll need time to prepare for the sessions, disease-mongering). but not so much time that you lose touch. Circulate the reading guide. It is usually best if one person leads each discussion, to have some questions at the ready and get things rolling. Although the challenge to disease-mongering is not unprecedented (the women’s health movement of the 1970s was another key historical moment), these books represent an impressive groundswell OR, maybe you’d like to of amazing, powerful, brilliant, and often deeply unsettling investigations by physicians, health scientists, 2) Set up a lecture/discussion group. -
A Molecular Basis for Nicotine As a Gateway Drug
The new england journal of medicine special article shattuck lecture A Molecular Basis for Nicotine as a Gateway Drug Eric R. Kandel, M.D., and Denise B. Kandel, Ph.D. From the Howard Hughes Medical Insti- n the historic occasion of the 122nd Shattuck Lecture and tute (E.R.K.), Kavli Institute for Brain Sci- the 200th anniversary of the New England Journal of Medicine, we chose to ad- ence (E.R.K.), and the Departments of Neuroscience (E.R.K.) and Psychiatry Odress a topic that is at once scientific and personally historic. In recent (E.R.K., D.B.K.), College of Physicians debates over legalizing marijuana, from all-out acceptance in Colorado to narrow and Surgeons, and Mailman School of decriminalization in Maryland, the scientific question of the role of marijuana as a Public Health (D.B.K.), Columbia Univer- sity, and the New York State Psychiatric gateway drug (i.e., a drug that lowers the threshold for addiction to other agents) Institute (D.B.K.) — all in New York. Ad- has loomed large. Both opponents and proponents of legalization have distorted dress reprint requests to Dr. E. Kandel at what science does and does not tell us — and both sides have overlooked the im- the Department of Neuroscience, Col- lege of Physicians and Surgeons, Colum- portance of nicotine as a gateway drug. bia University, 1051 Riverside Dr., Unit Epidemiologic studies have shown that nicotine use is a gateway to the use of 87, New York, NY 10032, or at erk5@ marijuana and cocaine in human populations. -
Greenshield.Ca MORE HEALTH CARE DOESN’T NECESSARILY MEAN BETTER HEALTH …But It Can Mean More Harm
AUGUST/SEPTEMBER 2019 Don’t miss episode 19 of our podcast as we discuss better approaches to health care with Dr. Danielle Martin, family physician, author, chief medical executive at Women’s College Hospital, and YouTube star. CLICK HERE TO LISTEN WHAT’S INSIDE MORE HEALTH CARE DOESN’T NECESSARILY MEAN BETTER HEALTH Page 2 WHAT’S UP... Drug pricing in the news Message of health care survey: evolve with the times Page 12 greenshield.ca MORE HEALTH CARE DOESN’T NECESSARILY MEAN BETTER HEALTH …But it can mean more harm Turns out that 60 really is the new 40—and even 80 is the new 60—as people worldwide are living longer. In fact, we can expect to live more than twice as long as our ancestors.1 So why then, if we are healthier and more active than ever, are more people becoming patients? It’s because health care is no longer considered just for the sick, it has expanded into also focusing on the well. At first blush, this may sound like a good thing; it may sound like prevention. But if your plan members are healthy—in that they don’t have health problems that need solving— health services may actually create problems. Problems like overdiagnosis and in turn, overtreatment—including all the anxiety, energy, time commitment, potential costs, and even physical harm that can come along with it. The controversy surrounding the medicalization of healthy people raises awareness of the difference between what is truly prevention versus what is just early diagnosis that may—or may not—be a good thing. -
Transcriptome Sequencing Reveals Candidate NF-Κb Target Genes Involved in Repeated Cocaine Administration Yan Wang, Huajing Teng, Daniel M
Copyedited by: oup International Journal of Neuropsychopharmacology (2018) 21(7): 697–704 doi:10.1093/ijnp/pyy031 Advance Access Publication: March 21, 2018 Regular Research Article regular research article Transcriptome Sequencing Reveals Candidate NF-κB Target Genes Involved in Repeated Cocaine Administration Yan Wang, Huajing Teng, Daniel M. Sapozhnikov, Quansheng Du, Mei Zhao Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences, China (Drs Wang and Zhao); University of Chinese Academy of Sciences, Beijing, China (Drs Wang, Teng, and Zhao); Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing China (Dr Teng); Department of Pharmacology and Therapeutics, McGill University Montreal, Quebec, Canada (Mr Sapozhnikov); Department of Life Sciences, National Natural Science Foundation of China, Beijing, China (Dr Du). Correspondence: Dr. Mei Zhao, 16 Lincui Road, Chao Yang District, Beijing 100101, China ([email protected]). Abstract Background: Drug-induced alterations in gene expression play an important role in the development of addictive behavior. Numerous transcription factors have been implicated in mediating the gene expression changes that occur in drug addiction. Nuclear factor kappa B is an inducible transcription factor complex that is rapidly activated by diverse stimuli. Methods: We performed next-generation high-throughput sequencing of the prefrontal cortex in a mouse model of repeated cocaine administration combined with pharmacological nuclear factor kappa B inhibition to identify nuclear factor kappa B target genes that participate in the cocaine addiction process. Results: We found that the nuclear factor kappa B antagonist sodium diethyldithiocarbamate trihydrate significantly reversed the cocaine-induced expression changes of the amphetamine addiction pathway. Genes that demonstrated differential expression in response to cocaine treatment that was also reversed by sodium diethyldithiocarbamate trihydrate were enriched for the axon guidance pathway. -
Therapy Manuals for Drug Addiction. Manual 1
i ACKNOWLEDGMENTS The development of earlier versions of this manual was supported by several research grants from the National Institute on Drug Abuse. The current manual was written by Dr. Kathleen Carroll of Yale University under Contract Number N-OIDA-4-2205 with the National Institute on Drug Abuse. Dr. Lisa Onken, the NIDA Project Officer, offered valuable guidance and comments throughout the preparation of this manual. The material presented in this manual is the result of a program of research by Dr. Kathleen Carroll and Dr. Bruce Rounsaville and their colleagues at Yale University. The development of this therapy model for treatment of drug abuse drew extensively from the work of Alan Marlatt and others (Marlatt and Gordon 1985; Chancy et al. 1978; Jaffe et al. 1988; Ito et al. 1984). The structure and sequence of sessions presented in this therapy model was partially developed by work on Project MATCH published by the National Institute on Alcohol Abuse and Alcoholism (Kadden et al. 1992) and the manual developed by Peter Monti and his colleagues (1989). These sources are particularly reflected here in the a skills-training material, and we have acknowledged the original sources in each of those sections. Yale University Research Team Coinvestigators: Bruce Rounsaville, M.D. Roseann Bisighini, M.S. Charla Nich, M.S. Monica Canning-Ball Sam Ball, Ph.D. Joanne Corvino, M.P.H. Lisa Fenton, Psy.D. Kea Cox Frank Gawin, M.D. Lynn Gordon, R.N. Tom Kosten, M.D. Tami Frankforter Elinor McCance-Katz, M.D., Ph.D. jenniffer Owler Douglas Ziedonis, M.D.