CURRICULUM VITAE

Sheila Collins

OFFICE ADDRESS: 354 Preston Research Building, 2220 Pierce Avenue, Medical Center, Nashville TN OFFICE PHONE NO.: 615-936-5863

EDUCATION

9/73-2/79 University of Massachusetts College of Natural Sciences (Amherst, MA), Bachelor of Science, 1979 (Zoology)

9/80-9/85 Massachusetts Institute of Technology School of Science (Cambridge, MA), PhD 1985 (Applied /Biology) 11/85-12/91 Postdoctoral Fellowship Duke University Medical Center, (Durham, NC)

LICENSURE AND CERTIFICATION Not applicable

ACADEMIC APPOINTMENTS 6/77 - 6/79 Research Assistant, Developmental Biology Laboratory Harvard Medical School & Massachusetts General Hospital, Boston, MA Supervisor: Dr. Jerome Gross 9/79 - 6/80 Senior Research Assistant, Division of Biology, California Institute of Technology, Pasadena, CA Supervisor: Dr. Tom Maniatis 1980 Summer Research Student, Divisions of Biology & Chemistry, California Institute of Technology, Pasadena, CA Mentors: Dr. Norman Davidson and Dr. James I. Mullins 9/80 - 9/85 Graduate Research Student, Massachusetts Institute of Technology, Cambridge, MA Mentor: Dr. Michael A. Marletta, thesis advisor

1984 Teaching Assistant, Massachusetts Institute of Technology, Cambridge, MA Course title: Mechanisms of Drug Action Mentor: Dr. R. Alan North, course instructor 1984 Teaching Assistant, Massachusetts Institute of Technology, Cambridge, MA Course title: Mechanisms of Drug Action Mentor: Dr. R. Alan North, course instructor 11/85 - 2/91 Postdoctoral Fellow Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC Mentors: Dr. Robert J. Lefkowitz and Dr. Marc G. Caron 3/91 - 2/92 Assistant Research Professor Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 2/92 - 6/94 Assistant Professor, Department of Medicine, GI Division, Duke University Medical Center, Durham, NC 7/94 - 6/97 Assistant Professor, Department of Psychiatry and Behavioral Sciences Assistant Professor, Department of Pharmacology Member, The Sarah W. Stedman Center for Nutritional Studies Duke University Medical Center, Durham, NC 7/97 - 4/04 Associate Professor, Department of Psychiatry and Behavioral Sciences Assistant Professor, Department of Pharmacology & Cancer Biology Member, The Sarah W. Stedman Center for Nutritional Studies Duke University Medical Center, Durham, NC 7/03 Awarded Tenure (NB: tenure of basic science faculty in Duke Medical School Clinical departments is uncommon and meritorious) Duke University Medical Center, Durham, NC 4/04 - 2/07 Senior Investigator / Director, Program in Endocrine Biology CIIT Centers for Health Research (renamed The Hamner Institutes), Research Triangle Park, NC 2/07 - 2/10 Senior Investigator Interim Director (for 2008), Division of Translational Biology The Hamner Institutes for Health Sciences, Research Triangle Park, NC 2/10 - 2017 Professor, Integrative Metabolism Program, Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 2018 – pres Professor, Cardiovascular Medicine, Dept of Medicine, Vanderbilt University Medical Center, Nashville, TN

HOSPITAL APPOINTMENTS Not applicable

PROFESSIONAL ORGANIZATIONS  University / Institute Committees 2011- 2017 Chair, Sanford Burnham Prebys Medical Discovery Institute-Lake Nona Institutional Animal Care and Use Committee, Orlando, FL 2010 – 2011 Vice-Chair, Sanford Burnham Medical Research Institute Lake Nona Institutional Animal Care and Use Committee, Orlando, FL 2006 – 2009 Member, The Hamner Institutes Institutional Animal Care and Use Committee, Research Triangle Park, NC 2007 – 2008 Member, Senior Management of the Hamner Institutes for Health Sciences, Research Triangle Park, NC 2002 Duke University Faculty Search Committee, Dept. of Molecular Genetics & Microbiology, Durham, NC 2002 Duke University Faculty Search Committee, Dept. of Pharmacology & Stedman Center, Durham, NC 1996 Chancellor’s Steering Committee on Obesity Research at Duke University Medical Center, Durham, NC 1995 – 2003 Duke University Dept. of Psychiatry representative to the Duke University Institutional Animal Care and Use Committee, Durham, NC

PROFESSIONAL ACTIVITIES  Editorial Boards and Reviewer Assignments 2016- Board of Consulting Editors, The Journal of Clinical Investigation 2007-2016 Editorial Board, International Journal of Obesity 2003-2007 Editorial Board, Molecular Endocrinology 2003-2006 Editorial Board, Obesity Research 2003-2006 Editorial Board, Endocrinology * regular reviewer for Diabetes, American Journal of Physiology, Nature, Cell, Cell Metabolism, Molecular and Cellular Biology, Endocrinology, Molecular Endocrinology, Nature Medicine, Diabetologia, Scientific Reports; Nature Communications

 Grant and Review Committees 2016 - present NIH CADO Study Section, NIDDK, Standing Member from August 2016 2015 - present American Diabetes Association, Research Grant Review Committee Member 2012 - present Keystone Symposia Board of Programming Consultants 2012 - present Keystone Symposia on Molecular and Cellular Biology, Study Group Member 2012 Chair, Program Project Grant Review, NIDDK, NIH: Mar 27 2011 NIH Reviewer, Special Study Section ES11-002, NIEHS, NIH, Oct 24-25 2011 Chair, Program Project Grant Review, NIDDK, NIH: Mar 23 2010 NIH Reviewer, CADO Study Section, NIDDK, NIH: Oct 14-15 2009 NIH Reviewer, CADO Study Section, NIDDK, NIH: Oct 5-6 2008 -2009 Member, American Heart Association Review Committee Basic Cell and Molecular Biology 4 2008 NIH Reviewer, Special Study Section, ZRG 1 MENR 02 M Aug 7-8 2006 Chair, Program Project Grant Review, NIDDK, NIH: Apr 24 2004-present Member, External Advisory Committee, University of Alabama, Birmingham NIH Nutrition and Obesity Research Center 2005 Invited Participant and Panelist, Society for Women's Health Research, Workshop on Sex and Gender Differences in Obesity and Cardiovascular Disease, Washington, DC, Nov 2-4 2001-2002 Ad Hoc Reviewer, Endocrinology Study Section, Ctr for Scientific Review, NIH 1999 NIH Reviewer, Special Study Section, SSS-T ZRG-NTN Obesity 1998-2001 Member, Metabolism Study Section, Center for Scientific Review, NIH 1999 NIH Reviewer, Special Emphasis Panel, ZRG1 BIO(01) 1998 NIH Reviewer, Special Emphasis Panel, ZRG2 MET(02) 1996-1998 Member, American Heart Association Molecular Signaling II National Grant Review Committee 2016 NIH Reviewer, CADO Study Section, NIDDK, NIH: Oct 13-14 2017 NIH Reviewer, CADO Study Section, NIDDK, NIH: Feb 22-24; June 14- 15  Retained Consulting Experience Merck Research Laboratories (Pharmacology and Obesity programs) Novo Nordisk (Obesity and Metabolic disease programs) Glaxo Wellcome / GSK (Respiratory, Cardiovascular and Metabolism programs) Lederle Labs/ Pharmaceuticals (Metabolic Disease program) Lexicon Genetics (Obesity and Metabolic disease programs) A variety of short-term consulting activities with domestic and international Pharma and Biotech.  Recognitions and Honors 2017 Keynote Speaker, Mid-Atlantic Pharmacology Society, Hosted by Temple University, Philadelphia, PA Oct 26, 2017 2016 Keynote Speaker, Alberta Diabetes Institute Research Day, University of Alberta, October 4, 2016 2013 14th Nelson Goldberg Lecturer, Dept of Biochemistry, University of Minnesota 2008 The Hamner Senior Fellow in Endocrine Biology 2006 Invited Speaker and Participant, The 134th Nobel Symposium, Sweden 1992-1994 Mal Tyor Junior Faculty Scholar, Duke University Medical Center 1986-1990 Howard Hughes Medical Institute Postdoctoral Fellow 1979 Magna Cum Laude, Department of Zoology, University of Massachusetts 1979 Commonwealth Honor Scholar, UMass Amherst

TEACHING ACTIVITIES (former)  Medical School and University Teaching (all at Duke University on an annual basis) PHR200B Problems in Pharmacology – case studies course in Medical Pharmacology for 1st year Medical School students. PTH385 Molecular Aspects of Disease – lecturer on obesity and diabetes for Pathology. PSY223 Molecular Basis of Behavior – lecturer on monoamine receptors for Psychology. Duke Medical School First Year Curriculum (new as of 2005) Block I; Molecules and Cells, Topic Lectures: Human Nutrition and Appetite Control. PSY272S Obesity and Eating Disorders – lecturer on molecular basis of appetite. Behavioral Neurosciences Study Program Faculty – lecturer on monoamine receptors and their regulation.

CLINICAL TEACHING Not applicable

RESEARCH SUPERVISION Predoctoral Trainees: 1. Wei Wu, Endocrinology and Metabolism Program, Huashan Hospital of Fudan University, Shanghai, China (research done in my lab); awarded PhD Jan 2017. 2. Andre R.G. Proença, Department of Physiology and Biophysics, Institute of Biomedical Sciences, Sao Paulo University, Sao Paolo, Brazil – 6-month research training internship; Awarded PhD, 2013. 3. Jingqi Fu, Pharmacology and Toxicology program, China Medical University, Beijing. 2008 – 2010 (co-mentor with Dr. Jingbo Pi). 4. Fatiha Moukdar, M.S., Ph.D. program, Pharmacology, Université de Montréal, Montréal, Canada. Part of thesis work conducted at Division of Biological Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, 2004-2008. Awarded PhD East Carolina Univ. 5. Tonya Martin Dixon, B.S. Ph.D. Pharmacology, Duke University, 2001.

6. Kurt J. Soeder, M.S. Pharmacology, Duke University, 2000. The 3-adrenergic receptor activates MAP kinase in adipocytes through a Gi-dependent mechanism. 7. Sheridan K. Snedden, M.S. Pharmacology, Duke University, 1999. Strain-specific regulation of the UCP2 gene. 8. Madlene K. Dole, M.S. Pharmacology, Duke University, 1998. Role of leptin in controlling pulsatility in hypothalamic neurons. 9. Ambieshie Yesus, M.D. student in the Duke Medical School; ADA-supported third year research.

Postdoctoral Trainees: 1. Ryan P. Ceddia, Ph.D. Jan 2016 - present 2. Fubiao Shi, Ph.D. Oct 2014 - present 3. Anne Bugge, Ph.D. Jul 2012 – Dec 2013 4. Eric Weatherford, Ph.D. Mar 2012-2014 5. Crystal Woodard, Ph.D. Jan 2012 – Dec 2015 6. Lea Dib, Ph.D. Sept 2011 – Nov 2013 7. Marica Bordicchia, Ph.D. Apr 2010 – Jan 2012 8. Ruidong Miao, Ph.D – July 2010 – May 2011 9. Cynthia Nagle, Ph.D. – 2008 - Feb 2010 10. Einav Yehuda-Shnaidman, Ph.D. 2007-2010 11. Dianxin Liu, Ph.D. 2006-2009 12. Haibo Wang, M.D., Ph.D. 2004-2009 13. Jingbo Pi, M.D., Ph.D. 2004-2007 14. Hui Quan, Ph.D. 2004-2006 15. Gabriel Guzman, Ph.D. 2004-2005 16. Naresh Kumar, Ph.D. 2003-2008 17. Yushi Bai, M.D., Ph.D. 2002-2006 18. Jacques Robidoux, Ph.D. 2000-2007 19. Hiroki Onuma, Ph.D. 1999-2000 20. Alexander V. Medvedev, Ph.D. 1998-2004 21. Wenhong Cao, M.S., M.D. 1998-2004 22. Shiying Wang, Ph.D. 1994-1997 23. Elizabeth M. Rohlfs, Ph.D. 1993-1994

Undergraduate Independent Study (Sanford Burnham Prebys - Lake Nona FL): 1. Liam Philben, 2013 & 2015 Summer Intern, now at University of Chicago 2. Adam Collin, 2014 Summer Intern, Florida State University – now Pharmacy student at University of Florida 3. Alexa Roth, 2010 Summer Intern. Then obtained B.S. in Microbiology, University of Florida 2014

Undergraduate Independent Study (Duke University): 1. Crystal Pressley 2001-2002. B.S. in Chemistry, Duke University, 2002 2. Caroline Hu, 1999-2000. B.S. in Biology, Duke University, 2000 3. Stephanie S. Ocon, 1998-1999. B.S. With Distinction in Chemistry, Duke University. (Ph.D., Biochemistry, Stanford University). 4. Ayanna Cooper. 1997. B.S. Biochemistry, UNC, Greensboro. (Ph.D., Pharmacology, Yale University). 5. Kevin David, 1996-1997. B.S. in Biology, Duke University. (M.D., Duke University School of Medicine). 6. Raj Fofaria, 1995-1996. B.S. in Biology, Duke University. (M.D., Medical College of Virginia). Also a recipient of a Duke Undergraduate Research Award grant in support of his independent study research. 7. Allison Brucker 1994-1995. B.S. in Biology, Duke University. (M.D., College of Physicians and Surgeons).

OTHER SIGNIFICANT ACTIVITIES (optional) Not applicable

RESEARCH PROGRAM Ongoing Support R01 DK103056 (Collins) 07/01/2014 – 04/30/2018 4.2 calendar NIH $217,500 Natriuretic peptide receptors (NPs), adipose browning, and energy expenditure The goal of this project is to determine tissues that respond to NPs by increasing energy expenditure and fatty acid oxidation by tissue-targeted deletion of NP receptor C in mice. Identify promoters and enhancers of the NP receptor A and C genes using reporter constructs and Chip-Seq. Test the hypothesis that the NP receptor A and C peptides can form heterodimers that will impede signal transduction as a form of negative regulation and understand the mechanism.

AHA GRFW 2016 #16SFRN28620000 (Kass) 04/01/2016 – 03/31/2020 0.6 calendar $37,673 Women and heart failure with a preserved ejection fraction: sex and menopause related mechanisms, risk biomarkers, and new treatment strategies In collaboration with Johns Hopkins and Northwestern Universities, the goal of this project is to study the role of sex hormones on cGMP/PKG modulation of cardiac hypertensive and systemic metabolic disease as it relates to heart failure in women in order to understand mechanisms involved, more reliably identify at risk patients, and develop novel treatments by contributing molecular and biochemical studies of human adipose tissue.

Completed Research Support Takeda Pharmaceutical (Kelly) 12/25/2010 – 12/31/2014 Title: Obesity drug target discovery project. Major goal: To identify novel non-CNS human targets and pathways relevant to the discovery of biomarkers and new therapeutic targets for treatment of obesity and its complications; in collaboration with clinical researchers at Florida Hospital Role: Collaborator

Novo-Nordisk Diabetes Innovation Award (Collins) 12/01/2012 – 07/01/2015 Title: Natriuretic peptide biologics for obesity and metabolic disease. Major goal: To test novel natriuretic peptide formulations on human adipocytes and in animal models to assess capacity to promote increased energy expenditure through ‘browning’ of adipocytes expressing UCP1.

American Diabetes Association #1-13-BS-030 (Collins) 01/01/2013 – 12/31/2015 Title: Adipocyte “browning” and body fat reduction by cardiac natriuretic peptides. Major goal: examine signaling mechanisms by which the natriuretic peptides ANP and BNP increase the ‘browning’ program in adipose tissue, and their coordination with the SNS in this process; transcriptional control of NPRA and NPRC receptors.

Bristol-Myers-Squibb CSRA 14-03FL (Collins) 12/03/2013 – 06/30/2016 Title: Effect of DPP‐IV inhibitors on efficacy of human BNP for fat oxidation and blood pressure control. Major goals: To determine if the cleavage of human BNP by DPP‐IV results in reduced biological activity. We are particularly interested to know whether DPP‐IV inhibitors can enhance BNP activity to increase fat metabolism, oxygen consumption and energy expenditure in adipose tissue.

NIH R56 DK106221 (Collins) 08/01/2016 – 07/31/2017 Title: New pathway by which PKA activates mTORC1 and role in adipose browning. Major goal: Assess the physiological consequences of specific inactivation of the PKA- mTORC1 pathway we have discovered using tissue-specific knock-in mice containing a mutation of the PKA site in Raptor that abrogates activity of mTORC1 through PKA., but not through the insulin signaling pathway. Studies include adipocyte cell lines expressing this mutation by CRISPR-Cas9.

Pending Research Support R01 DK116625 (Collins) 12/01/2017 – 11/30/2022 4.2 calendar NIH $338,878 Dissecting PKA activation of mTORC1 and its function in adipose tissue The goal of this project is to establish the contribution of the mTORC1 complex and role of Raptor in particular in adipose tissue and βAR and PKA-dependent generation of energy burning UCP1-expressing ‘beige’ adiposcytes in white fat depots. The goal is to understand the mechanics of this pathway to ultimately find molecules that can selectively increase fat burning to fight obesity.

PUBLICATIONS AND PRESENTATIONS Peer-Reviewed Publications 1. Collins S, Marletta MA (1984). Carcinogen binding proteins: high affinity binding sites for Benzo[a]pyrene in mouse liver distinct from the Ah receptor. Mol Pharmacol 26: 353-359. 2. Collins S, Altman JD, Marletta MA (1985). Development of an affinity chromatography resin for the purification of carcinogen binding proteins from mouse liver. Biochem Biophysl Res Commun 129: 155-162. 3. Collins S, Marletta MA (1986). Purification of a Benzo[a]pyrene binding protein by affinity chromatography and photoaffinity labeling. Biochemistry 25: 4322-4329. 4. Bouvier M, Hnatowich M, Collins S, Kobilka BK, DeBlasi A, Lefkowitz RJ Caron MG (1987). Expression of a human cDNA encoding the β-adrenergic receptor in chinese hamster fibroblasts (CHW): Functionality and regulation of the expressed receptors. Mol Pharmacol 33: 133-139. 5. Kobilka BK, Frielle T, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, Caron, MG (1987). An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329: 75-79. 6. Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK (1987). Cloning of the cDNA for the human β1-adrenergic receptor. Proc Natl Acad Sci USA 84: 7920-7924. 7. Collins S, Quarmby French FS, Lefkowitz RJ, Caron MG (1988). Regulation of the β2- adrenergic receptor and its mRNA in the rat ventral prostate by testosterone. FEBS Letters 233: 173-176. 8. Collins S, Caron MG, Lefkowitz RJ (1989). β2-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 263: 9067-9070. 9. Bouvier M., Collins S, de Blasi A, Campbell P, Irons G, MacGregor C, Caron MG, Lefkowitz RJ (1989). Two distinct pathways for cAMP mediated down regulation of the β2- adrenergic receptor: Phosphorylation of the receptor and regulation of its mRNA level. J Biol Chem 264: 16786-16792. 10. Collins S, Bouvier M, Bolanowski MA, Caron MG, Lefkowitz RJ (1989). Cyclic AMP stimulates of the β2-adrenergic receptor gene in response to short term agonist exposure. Proc Natl Acad Sci USA 86: 4853-4857. 11. Lorenz W, Lomasney JW, Collins S, Regan JW, Caron MG, Lefkowitz RJ (1990). Expression of three alpha-2 adrenergic receptor subtypes in rat tissues: implications for alpha-2 receptor classification. Mol Pharmacol 38: 599-603. 12. Izzo N, Seidman CE, Collins S, Colucci WS (1990). β1-Adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells. Proc Natl Acad Sci USA 87: 6268-6271. 13. Collins S, Altschmied J, Herbsman O, Caron M G, Mellon PL, Lefkowitz RJ (1990). A cyclic AMP response element in the β2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. J Biol Chem 265: 19330-19335. 14. Collins S, Ostrowski J, Lefkowitz RJ (1993). Cloning and sequence analysis of the human β1-adrenergic receptor 5'-flanking promoter region. Biochim Biophys Acta 1172: 167-170. 15. Collins S, Daniel KW, Rohlfs EM, Ramkumar V, Taylor IL, Gettys TW (1994). Impaired expression and functional activity of the β3- and β1-adrenergic receptors in adipose tissue of congenitally obese (C57Bl/6J ob/ob) mice. Mol Endocrinol 8: 518-527. 16. Gettys TW, Rohlfs EM, Prpic V, Daniel KW, Taylor IL, Collins S (1995). Age-dependent changes in β-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 136: 2022-2032. 17. Rohlfs EM, Daniel KW, Premont RT, Kozak LP, Collins S (1995). Regulation of the uncoupling protein gene (Ucp) by β1-, β2-, and β3-adrenergic receptor subtypes in immortalized brown adipocyte cell lines. J Biol Chem 270: 10723-10732. 18. Wetsel WC, Liposits Z, Seidah NG, Collins S (1995). Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. Neuroendocrinology 62: 166-177. 19. Collins S, Surwit R (1996). Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271: 9437-9440. 20. Collins S, Kuhn C, Petro AE, Chrunyk B, Swick AG, Surwit RS (1996). Leptin and fat regulation. Nature 380: 677.

21. Collins S, Daniel KW, Petro AE, Surwit RS (1997). Strain-specific response to 3AR agonist treatment of diet-induced obesity in mice. Endocrinology 138: 405-413. 22. Gettys TW, Watson PM, Taylor IL, Collins S (1997). RU-486 (mifepristone) ameliorates diabetes but does not correct deficient -adrenergic signaling in adipocytes from C57BL/6J- ob/ob mice. Int J Obesity 21:865-873. 23. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH (1997). Uncoupling protein-2: a novel gene lined to obesity and hyperinsulinemia. Nature Genet 15: 269-272. 24. Surwit RS, Petro AE, Parekh P, Collins S (1997). Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes 46: 1516-1520. 25. Aubert J, Champigny O, Saint-Marc P, Negrel R, Collins S, Ricquier D, Ailhaud G (1997). Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. Biochem Biophys Res Commun 238: 606-611. 26. Surwit RS, Wang S, Petro AE, Sanchis D, Raimbault S, Ricquier D, Collins S (1998). Diet- induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. Proc Natl Acad Sci USA 95: 4061-4065. 27. Sanchis D, Fleury C, Chomicky N, Neverova M, Grégoire F, Rivest S, Richard D, Goubern M, Raimbault S, Miroux B, Collins S, Warden CH, Bouillaud F and Ricquier D (1998). BCMP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J Biol Chem 273: 34611-34615. 28. Collins S, Daniel KW, Rohlfs EM (1999). Depressed expression of adipocyte -adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Int J of Obesity 23: 669-677.

29. Soeder KJ, Snedden SK, Della Rocca GD, Luttrell LM. Collins S (1999). The 3-adrenergic receptor activates MAP kinase in adipocytes through a Gi-dependent mechanism. J Biol Chem 274: 12017-12022.

30. Surwit RS, Dixon TM, Petro A, Daniel KW, Collins S (2000). Diazoxide restores 3- adrenergic receptor function in diet-induced obesity and diabetes. Endocrinology 141:3630- 3637. 31. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Collins S, Ricquier D (2000). Disruption of uncoupling protein-2 (UCP2) reveals a role in immunity and production of reactive oxygen species. Nature Genet 26: 435-439. 32. Cao W, Luttrell LM, Medvedev AV, Pierce KL, Lefkowitz RJ, Collins S (2000). Direct binding of activated c-Src to the 3-adrenergic receptor is required for MAP kinase activation. J Biol Chem 275: 38131-38134. 33. Dixon TM, Daniel KW, Farmer SR, Collins S (2001). C/EBP is required for transcription of the 3AR gene during adipogenesis. J Biol Chem 276: 722-728. 34. Pecqueur C, Alves-Guerra M-C, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F, Miroux B (2001). Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem 276: 8705-8712. 35. Medvedev AV, Snedden SK, Raimbault S, Ricquier D, Collins S (2001). Transcriptional regulation of the mouse UCP2 gene: double E-box-like element is required for PPAR- dependent activation. J Biol Chem 276: 10817-10823. 36. Surwit RS and Collins S, (2001). Revisiting lessons from the C57BL/6J mouse. Am J Physiol 280:E825-826. 37. Cao W, Medvedev AV, Daniel KW, Collins S (2001). -Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein-1 (UCP1) gene requires p38 MAP kinase. J Biol Chem 276: 27077-27082. 38. Kreda S, Sumner M, Fillo S, Ribeiro C, Luo G, Xie W, Daniel KW, Shears S, Collins S, Wetsel WC (2001). 1-Adrenergic receptors mediate LHRH secretion through phospholipases C and A2 in immortalized hypothalamic neurons. Endocrinology 142: 4839- 4851. 39. Aubriot S, Nicolle E, Lattier M, Morel C, Cao W, Daniel KW, Collins S, Leclerc G, Faure P (2002). New series of aryloxypropanolamines with both human 3-adrenoceptor activity and free radical scavenging properties. Bioorg Med Chem Lett 12: 209-212. 40. Medvedev AV, Robidoux JR, Bai X, Cao W, Floering LM, Daniel KW, Collins S (2002). Transcriptional regulation of the UCP2 gene in pancreatic INS-1 cells: dual regulation by sterol response element and E-box binding factors. J Biol Chem 277: 42639-42644. 41. Cao W, Daniel KW, Robidoux, J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman, BM, and Collins S (2004). p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol 24: 30573067. 42. Bai Y, Onuma H, Bai X, Medvedev AV, Misukonis M , Weinberg JB, Cao W, Robidoux J, Floering LM, Daniel KW, Collins S (2005). Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. J Biol Chem 280: 19062-9. 43. Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S (2005). Selective activation of mitogen-activated protein (MAP) kinase-kinase-3 and p38alpha MAP kinase is essential for cAMP-dependent UCP1 expression in adipocytes. Mol Cell Biol 25: 5466-5479. 44. Cao W, Collins QF, Becker TC, Robidoux J, Lupo, Jr., EG, Xiong Y, Daniel KW, Floering LM, Collins S (2005). p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. J Biol Chem 280: 42731-42737. 45. Robidoux J, Kumar N, Daniel KW, Moukdar F, Medvedev AV, Cyr M, Collins S (2006). Maximal β3-adrenergic regulation of lipolysis involves epidermal growth factor receptor- dependent ERK1/2 activation. J Biol Chem 28: 37794-37802. 46. Kumar N, Robidoux J, Daniel K,, Floering L, Cao W, Collins S (2007). Recruitment of vimentin to β3-adrenergic receptor and its role in ERK activation and lipolysis. J Biol Chem 282: 9244-9250. 47. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E Molina AJA, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai O (2007). β-cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes 56: 2569-2578. 48. Pi J, Bai Y, Reece JM, Williams J, Liu, D, Freeman,ML, Fahl WE, Shugar D, Liu J, Qu W, Collins S, Waalkes MP (2007). Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free Radic Biol Med 42: 1797-806. 49. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Deeny JT, Anderson ME, Corkey BE, Collins S (2007). Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56: 1783-91. 50. Pi J, Zhang Q, Woods CG, Wong V, Collins S, Andersen ME (2008). Activation of Nrf2- mediated oxidative stress response in macrophages by hypochlorous acid. Toxicol Appl Pharmacol 226: 236-43. 51. Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Mangelsdorf DJ, Collins S (2008). Liver X receptor is a transcriptional repressor of the uncoupling protein-1 gene and the brown adipocyte phenotype. Mol Cell Biol 28: 2187-2200. 52. Kumar N, Liu D, Wang H, Robidoux J, Collins S (2008). Orphan nuclear receptor NOR-1 enhances cAMP-dependent Uncoupling protein-1 gene transcription. Mol Endo 22: 1057- 1064. 53. Liu H-Y, Collins QF, Xiong Y, Lupo EG, Moukdar F, Collins S, Cao W (2008). Human neutrophil alpha-defensins inhibit hepatic gluconeogenesis through a novel signaling pathway involving c-Src. J Biol Chem 283: 12056-12063. 54. Kumar N, Wang H, Liu D, Collins S (2009). Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes. Int J Obesity 33: 519-524. 55. Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S (2009). Persistent oxidative stress due to the absence of UCP2 associated with impaired pancreatic beta-cell function. Endocrinology 140: 3040-3048 (with ‘News and Views’ highlight by R. Kulkarni). 56. Moukdar F, Robidoux J, Lyght O, Pi J, Daniel KW, Collins S (2009). Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice. J Lipid Res 50: 59-70. 57. Hao Q, Hansen JB, Petersen RK, Hallenborg P, Jørgensen C, Cinti S, Larsen PJ, Steffensen KR, Wang H, Collins S, Wang J, Gustafsson J-Å, Madsen L, Kristiansen K (2010). ADD1/SREBP1c activates the PGC1-[alpha] promoter in brown adipocytes. Biochim Biophys Acta - Molecular and Cell Biology of Lipids. 1801: 421-9. 58. Fu J, Woods CG, Yehuda-Shnaidman E, Zhang Q, Wong V, Collins S, Sun G, Anderson ME, Pi J (2010). Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect 118: 864-70. 59. Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME (2010). ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol 244: 77-83. 60. Yehuda-Shnaidman E, Buehrer B, Pi J, Kumar N, Collins S (2010). Acute stimulation of white adipocyte respiration by PKA-induced lipolysis. Diabetes 59: 2474-2483. 61. Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lvsiak JJ, Hoehn KL, Ravichandran KS (2011). Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature 477:220-4. 62. Rogers C, Moukdar F, McGee MA, Davis B, Buehrer B, Daniel KW, Collins S, Barakat H, Robidoux J (2012). EGF receptor (ERBB1) abundance in adipose tissue is reduced in insulin- resistant and type 2 diabetic women. J Clin Endo Met 97:E329-E340 (accompanied by Special Feature editorial). 63. Bordicchia M, Liu D, Amri E, Ailhaud G, Dessi-Fulgheri P, Zhang C, Takahashi N, Sarzani R, Collins S (2012). Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest 122:1022-1036 (accompanied by special News and Views editorial). 64. Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K,Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S…..Moscat J, Tschöp MH (2013). p62 links β-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest 123:469–478. 65. Dib L, Bugge A, Collins S (2014). LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes. J Lipid Res 55:247-257. 66. Mazar J, Zhao W…Collins S, Perera R (2014). The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells. Oncotarget 15:8959-69. 67. Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li J-L, Guilherme A, Guntur K, Czech MP, Collins S (2016). Activation of mTORC1 is essential for β-adrenergic stimulation of adipose ‘browning’. J Clin Invest 126 (5):1704-1716. 68. Kovacova Z, Tharp WG, Liu D, Wei W, Xie H, Collins S#, Pratley RE# (2016). Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes. Obesity 24:820-828. # Co-corresponding authors. 69. Wu W*, Shi F*, Liu D, Ceddia RP, Gaffin R, Wei W, Fang H, Lewandowski ED, Collins S (2017). Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance Sci Signal Jul 25;10(489). doi: 10.1126/scisignal.aam6870. (Featured article for issue cover and accompanying Podcast). * These two authors contributed equally. 70. Liu D, Ceddia RP, Collins S (2018). Cardiac natriuretic peptides promote adipose browning’ through mTOR complex-1. Mol Metab. 9:192-198. 71. Ragni M*, Ruocco C*, Carullo P, Ghini V, Piscitelli F, Cutignano A, Manzo E, Tedesco L, Greco C, Rossi F, Pino A, Severi I, Liu D, Ceddia RP, Tenori L, Bifari F, Sala M, Decimo I, Di Marzo V, Luchinat C, Collins S, Cinti S, Carruba MO, Condorelli G, Valerio A, Nisoli E (2017). Amino acid-defined diet prevents and reverses obesity and diabetes by increasing energy expenditure. Nature Med (in revision). * These two authors contributed equally. 72. Fischer K, …. Collins S, … Diaz-Meco M, Moscat J, Tschöp M, Müller T (2018). The scaffold protein p62 regulates adaptive thermogenesis via modulation of Atf2 translocation (submitted) [For me this is a very important set of experiments that validates in spectacular fashion that the our very first observations for an important role of p38 MAPK dependent upon PKA, and links our previous studies on p62 to this axis for regulating brown adipocyte gene transcription]

Select Invited Review Articles 1. Collins S, Bolanowski MA, Caron MG and Lefkowitz RJ. Genetic regulation of β- adrenergic receptors. Ann Rev Physiol 51: 203-215, 1989. 2. Collins S, Bouvier M, Lohse MJ, Benovic JL, Caron MG and Lefkowitz RJ. Mechanisms regulating adrenergic receptor responsiveness. Biochem Soc Trans. 18: 541-544, 1990. 3. Collins S, Lohse MJ, O'Dowd B, Caron MG, Lefkowitz RJ. Structure and regulation of G protein-coupled receptors: the 2-adrenergic receptor as a model. In: Vitamins and Hormones (G.D. Aurbach, Ed) Vol 46: 1-39. Academic Press, 1991. 4. Collins S, Caron MG and Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Ann Rev Physiol 53: 497-508, 1991. 5. Collins S, Caron, M.G. and Lefkowitz RJ. From ligand binding to gene transcription: new insights into the regulation of G protein-coupled receptors. Trends in Biochemical Sciences 17: 37-39, 1992. 6. Collins S. Molecular structure of G protein-coupled receptors and regulation of their expression. The 2-adrenergic receptor as a model. In: Drug News and Perspectives (B. Spilker, editor) 6: 480-487, 1993. 7. Collins S. Recent perspectives on the molecular structure and regulation of the β2- adrenoceptor. Life Sciences 52: 2083-2091, 1993. 8. Collins S, Cao W, Soeder KJ and Snedden, SK. -adrenergic receptor signaling in adipocytes. In: Adipocyte Biology and Hormone Signaling IOS Press. 37:51-59, 2000. 9. Collins S, Cao W, Dixon TM, Daniel KW, Onuma H, Medvedev AV. Body weight regulation, uncoupling proteins, and energy metabolism. Nutrition and Gene Expression, CRC Press. Editors: N Moustaid & C Berdanier pps. 261-282, 2001. 10. Collins S, and Surwit, RS. The -adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Progress in Hormone Research, The Endocrine Society Press. Editor: AR Means. 56: 309-328, 2001. 11. Collins S, Cao W, Daniel KW, Dixon TM, Medvedev AV, Onuma H, Surwit RS. Adrenoceptors, Uncoupling Proteins and Energy Expenditure. Experimental Biology and Medicine 226: 982-990, 2001. 12. Robidoux J, Martin TL, Collins S. β-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol 44: 297-323, 2004. 13. Collins S, Martin TL, Surwit RS, Robidoux J. Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiology and Behavior 81: 243-248, 2004. 14. Collins S, Cao W, Robidoux J. Learning new tricks from old dogs: β-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol 18: 2123-2131, 2004. 15. Pi J and Collins S. Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function. Diabetes, Obesity and Metabolism 12 (Suppl.2): 141-148, 2010. 16. Collins S, Yehuda-Shnaidman E and Wang H. Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks. Int J of Obesity 34: S28-S33, 2010. 17. Collins S. Can having fun protect you from obesity and its cancer risk? Pigment Cell and Melanoma Research 25: 2-4, 2011. 18. Collins S. β-adrenergic signaling networks in adipocytes for recruiting stored fat and energy expenditure. Frontiers in Cellular Endocrinology Vol 2 art 102 doi: 10:3389/ fedno.2011.00102. Jan 2012. 19. Collins S and Bordicchia M. Heart hormones fueling a fire in fat. Adipocyte 2: 104-108, 2013. 20. Bugge A, Dib L, Collins S. Measuring respiratory activity of adipocytes and adipose tissues in real time. Methods in Enzymology 538: 233-247, 2014. 21. Collins S. A heart-adipose connection in the regulation of energy metabolism. Nat Rev Endocrinol 10: 157-163, 2014. 22. Shi F and Collins S. Second messenger signaling mechanisms of the brown adipocyte thermogenic program: an integrative perspective. Hormone Molecular Biology and Clinical Investigation (in press), 2017.

Selected Textbook Chapters 1. Collins S, Ahima R, Kahn BB. Biology of Adipose Tissue. Joslin’s Diabetes, 14th Edition. C Ron Kahn MD, Gordon C Weir MD, et al. (Eds.) Lippincott, Williams and Wilkins, 2005. 2. Collins S, Bai Y, Robidoux J. Adipose Tissue Development and Metabolism. Principles of Molecular Medicine, 2nd Edition. (Chpt 51.) Marschall S Runge, MD, PHD, Cam Patterson MD (Eds.) Humana Press, 2006. 3. Collins S, Migliorini RH, Bartness TJ. Mechanisms controlling adipose tissue metabolism by the sympathetic nervous system: anatomical and molecular aspects. Handbook of Contemporary Neuropharmacology. David R. Sibley (Ed.) John Wiley and Sons, 2007. 4. Collins S, Pi J, Yehuda-Shnaidman E. Uncoupling and ROS – a double-edged sword for β- cell function?“Moderation in all things” Mitochondria in Endocrinology, edited by Pierre Maechler, in: Best Practice & Research Clinical Endocrinology & Metabolism (Christoph Meier, Editor-in-Chief) Volume 26, Issue 6, Pages 709-820, I1-I2 (December 2012).

Selected Invited Conference Presentations

1. Regulation of β2-Adrenergic Receptors by Cyclic AMP. Symposium on Molecular Biology and Pathophysiology of Hormone Regulation and Actions, July 16-18, 1989. Center for High Blood Pressure Research, University of Heidelberg, Heidelberg, Germany

2. The Role of Cyclic AMP and Other Hormones in the Regulation of β2-Adrenergic Receptor Function. International Symposium on Genetic Factors in Hypertension, Directors' Meeting of the SCOR in Hypertension, National Heart, Lung and Blood Institute, Sept. 25-26, 1989, Boston, MA 3. Mechanisms Involved in Adrenergic Receptor Desensitization. Joint Colloquium on Glycoprotein Receptors and Cell Triggering, 633rd Meeting of the Biochemical Society, Dec. 18-20, 1989, St. Bartholomew's Hospital, London, UK 4. Multiple Pathways Regulating Adrenergic Receptor Responsiveness. Binational Science Foundation (BSF) Joint US-Israel Workshop on Expression and Modulation of Receptors in Normal and Diseased Tissues, sponsored by BSF and NINDS, The Weizmann Institute of Science, Oct. 7-10, 1990, Rehovot, Israel 5. Multiple Pathways Regulating Adrenergic Receptor Responsiveness. Fidia Research Foundation Symposium on Neurotransmitter Regulation of Gene Transcription, Satellite of the 20th Annual Meeting of the Society for Neuroscience, Oct. 25-27, 1990, St. Louis, MO 6. Transcriptional and Post-transcriptional Pathways Regulate G Protein-Coupled Receptor Expression. Symposium of the 5th World Congress of Biological Psychiatry: Transcriptional Regulation of Receptors: Structure and Function, June 9-14, 1991, Florence, Italy 7. Molecular Biology of the β-adrenergic Receptor. Satellite Symposium on β-Agonists in Respiratory Disease, June 18-19, 1992, Amsterdam, Netherlands

8. Regulation of β2-Adrenergic Receptor Gene Transcription and Implications for Cell Signaling. Serono International Symposium on G Protein-Associated Membrane Receptors: Molecular Biology, Signal Transduction and Physiology, September 21-23, 1992, Geneva, Switzerland

9. Genetic Control of β2-Adrenergic Receptors. 2nd European Pulmonary Summit, March 20- 26, 1993, Zug/Lech Arlberg, Austria 10. Molecular Biology of the β2-Adrenoceptor. Symposium on β-Adrenoceptor Agonists and the Airways, British Pharmacological Society Spring Meeting, April 12-15, 1994, Manchester, UK

11. Effects of 3AR Agonists to Prevent Obesity and Regulate AR Subtype Expression in Adipocytes. The Eighth International Catecholamine Symposium, October 13-18, 1996, Asilomar Conference Center, Pacific Grove, CA

12. Thermogenesis and Body Composition: the β3AR and the Mitochondrial UCPs. The Dr. George W. Raiziss Biochemical Rounds, Dept. of Biochemistry and Biophysics, University of Pennsylvania, March 31, 1998, Philadelphia, PA 13. β-Adrenergic Receptor Function in Adipocytes. IBC Industry Briefing on the Adipocyte: Targets for Therapy, April 1, 1998, The Ritz-Carlton Tysons Corner, McLean, VA

14. β3-Adrenergic Receptors, Brown Fat and Thermogenesis. American Diabetes Association 58th Annual Scientific Sessions, June 13-16, 1998 Chicago, IL 15. Regulation of the Uncoupling Protein Genes by Nutrients and Hormones. 8th International Congress on Obesity, August 29-Sept 3, 1998 Paris, France 16. Adrenergic Signaling in Adipocytes 27th Steenbock Symposium, Adipocyte Biology and Hormone Signaling, June 6-9, 1999, University of Wisconsin-Madison\ 17. Signaling and Regulation of Adipocyte -Adrenergic Receptors Keystone Symposium on Molecular Control of Adipogenesis and Obesity, February 16-22, 2000, Taos, New Mexico 18. G protein coupled receptor cross-talk between the PKA and MAP kinase cascades: stories of the adipocyte 3-adrenergic receptor ASPET-Ray Fuller Symposium: Insulin Resistance in Diabetes and Hypertension: Syndrome X and Beyond, March 24-26, 2000 London, Ontario, Canada 19. -adrenoceptor signaling through MAP kinase Joint meeting of the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists and the British Pharmacological Society, April 26-28, 2000, Melbourne, Australia 20. Adipocyte adrenergic signaling mechanisms and cross-talk Keystone Symposium on PPARs: A Transcription Odyssey, February 4-9, 2001 Keystone, CO 21. Adipocyte adrenergic signaling mechanisms and cross-talk 9th International Catecholamine Symposium, April 1-5, 2001 Kyoto, Japan 22. Molecular/cellular determinants of adrenergic signaling in adipocytes FASEB Summer Conference, Obesity: advances from the gene to the environment. August 18-23, 2001 Snowmass, CO 23. Fat cell adrenoceptors and the control of adipose tissue metabolism The Gerald Friedman Symposium 49th Annual Scientific Meeting October 28, 2001 Waldorf-Astoria Hotel, New York, NY 24. Control of UCP1 expression by PKA/p38 MAPK and PGC1. Keystone Symposium on Molecular Control of Adipogenesis and Obesity, January 10-16, 2002, Keystone, CO

25. Mechanisms of 3AR signaling in adipocytes and functional consequences on thermogenesis Int. Union of Pharmacology XIVth Congress, in Symposium Obesity: Innovative Therapeutic Approaches Based on Pharmacology Insights July 9, 2002 San Francisco, CA 26. The adipocyte ARs: signaling mechanisms and dysregulation in obesity, International Association for the Study of Obesity (IASO) Stock Conference on Adipose Tissue: New therapeutic targets from molecular and genetic studies. March 24-26, 2003 Lisbon, Portugal 27. Signal transduction and transcriptional pathways regulating UCPs. Workshop on Uncoupling Proteins:Current Status and Therapeutic Prospects. Instituto Juan March, Centre for International Meetings on Biology April 6, 2005 Madrid, Spain 28. Boston Obesity Nutrition Research Center, Adipose & Metabolic Tissue Study Group, April 19, 2005 Boston, MA 29. Obesity in the 21st Century: Genetics, environmental factors, or both? Dept. of Biochemistry, Molecular Biology & Biophysics, University of Minnesota. April 20, 2005 Minneapolis, MN 30. Biochemical mechanisms that regulate body weight, 6th Symposium on Molecular and Physiological Aspects of Type II Diabetes and Obesity, Nobel Forum, Wallenbergsalen, Karolinska Institutet, Nobels väg 1, Solna. April 22, 2005 Stockholm, Sweden 31. MAPK signaling networks in adipocytes, 45th National Congress of the Sociedad Mexicana de Nutrición y Endocrinología A.C. (Mexican Society of Nutrition and Endocrinology) November 29, 2005 Merida, Mexico 32. Signaling networks fueling mitochondrial metabolism in fat. Diabetes Mellitus, Keystone Symposia, January 23, 2006 Vancouver, Canada 33. Targeted disruption of Ucp2 gene causes inflammation and chronic activation of IKK in macrophages. 66TH Scientific Sessions, American Diabetes Association, June 10, 2006 Washington, DC 34. Integration of catecholamine signaling pathways in the adipocyte. The 134th Nobel Symposium, University of Göteborg August 8, 2006 Göteborg, Sweden 35. Kinases and their transcription targets in adipocyte cell fate. Molecular Control of Adipogenesis and Obesity, Keystone Symposia, February 23, 2008. Banff Springs, Alberta, Canada 36. Oxidative stress, UCP2 and β-cell function. Islet and Beta Cell Biology, Keystone Symposia, April 6-11, 2008 Snowbird, UT 37. Uncoupling proteins, ROS and β-cell function. Membrane Transport Proteins, Gordon Research Conference, July 20-25, 2008, Il Ciocco, Italy 38. Mitochondrial reactive oxygen species and glucose-stimulated insulin secretion. Role of Oxidative Stress in Aging and Age-Related Diseases, Gordon Research Conference, March 2009, Il Ciocco, Italy 39. A good side of ROS as a signal in pancreatic β-cells. Symposium presentation at American Diabetes Association Annual Scientific Sessions, June 2009, New Orleans, LA 40. Signaling networks regulating Ucp1 and brown fat thermogenesis The 12th Annual International Symposium, Merck-Frosst /CIRH Research Chair in Obesity: Rediscovering Brown Adipose Tissue November 6, 2009, Auberge Saint-Antoine, Quebec, Canada 41. Role of p38 MAP kinase in conveying β-adrenergic activation of brown fat thermogenesis. Brown Adipose Tissue and Human Obesity – An ICO 2010 Pre-congress meeting, Stockholm University, July 2010, Stockholm, Germany 42. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. Genetic and Molecular Basis of Obesity and Body Weight Regulation, Keystone Symposia, February 2012, Santa Fe, MN 43. Cardiac natriuretic peptide receptor signaling promotes ‘brown’ adipocyte expansion and energy expenditure. BENZON SYMPOSIUM No. 58 Adipose Tissue in Health and Disease, August 27-30, 2012, Copenhagen, Denmark 44. Cyclic nucleotides and energy balance. University of Bonn Institute of Pharmacology and Toxicology Seminar Series, December 17, 2012, Bonn, Germany 45. Converging cyclic nucleotide second messengers regulate fat metabolism. The 2013 Nelson D. Goldberg Lecture, University of Minnesota, March 6, 2013, Minneapolis, MN 46. Guest Lecturer, University of Copenhagen Faculty Club, April 18, 2013, Copenhagen, Denmark 47. Turing White Fat to Beige and Brown. Copenhagen Obesity Symposium, April 19-21, 2013, Gentofte, Denmark 48. Natriuretic peptides and fat metabolism. 6th International Conference on cGMP, June 28-30, 2013, Erfurt, Germany 49. Signaling Networks "Britening" Adipocytes: Some Old, Some New. Keystone Symposia: Lipid Pathways in Biology and Disease. Royal Dublin Society, March 19-24, 2014, Dublin, Ireland 50. Heart-Adipose Connection for Metabolism and Energy Expenditure. Cardiovascular Medicine Grand Rounds Distinguished Speaker, University of Louisville Dept. of Medicine, and Institute for Diabetes Center, April 16, 2014, Louisville, KY 51. Adipose Tissue Shades of Brown and How We Get There. The 15th Annual International Symposium, Merck-Frosst /CIRH Research Chair in Obesity: G Protein Coupled Receptors in Energy Expenditure, November 9, 2014, Auberge Saint-Antoine, Quebec, Canada 52. Mechanisms Increasing Mitochondria and Adipose Browning for Energy Expenditure. International Diabetes Federation World Diabetes Congress 2015 Nov 30 – Dec 4, 2015, Vancouver, Canada 53. Integrating Signaling Mechanisms for Adipose ‘Browning’. Obesity and Adipose Tissue Biology, Keystone Symposia, February 2016, Banff, Alberta, Canada 54. Evolving Role of Adipose Tissue: From Storage Locker to Metabolic Integrator. University of Alberta, 2016 Alberta Diabetes Institute Research Day – Keynote Speaker, October 2-5, 2016, Edmonton, Alberta, Canada 55. Regulators of Brown and ‘Beige’ Adipose Metabolism and Energy Expenditure: New Twists on an Old Story. The Scripps Research Institute, November 2-4, 2016, Jupiter, FL 56. Signaling Mechanisms Controlling White and Brown Fat Metabolism and Energy Expenditure. University of South Florida, January 29-31, 2017, Tampa, FL 57. Signaling Mechanisms Controlling White and Brown Fat Metabolism and Energy Expenditure. University of California, Berkeley, February 13-17, 2017, San Francisco, CA 58. Natriuretic Peptides in Fuel Metabolism and Insulin Sensitivity: Studies from Mouse Models and Humans. 60th German Conference on Endocrinology, March 15-17, 2017, Würzburg, Germany 59. Role of PKA-activated mTOR in Fat Cell Metabolism and Thermogenesis. 13th Insulin Receptor and Insulin Action Meeting, April 18-22, 2017, Nice, France 60. Integrating New and Old Hormonal Signaling Mechanisms Regulating Brown Adipose Function. International Conference on Translational and Therapeutic Perspectives of Brown Adipose, May 2-5, 2017, Copenhagen, Denmark 61. Signaling Mechanisms Controlling White and Brown Fat Metabolism and Energy Expenditure. EMBO Workshop on Brown Adipose Tissue, May 23-28, 2017, Sitges, Barcelona, Spain 62. Signaling Mechanisms Controlling White and Brown Fat Metabolism and Energy Expenditure. Helmholtz-Nature Medicine Diabetes Conference, September 17-19, 2017, Munich, Germany 63. Receptor Signaling in Adipocytes for Energy Expenditure and Metabolic Health. Mid- Atlantic Pharmacology Society Symposium, October 25-27, 2017, Philadelphia, PA 64. Cardiometabolic Communication Controlling White and Brown Fat Metabolism and Energy Expenditure. Albert Einstein Diabetes Center Conference, November 2-3, 2017, Bronx, NY 65. Signaling Mechanisms Controlling White and Brown Adipocyte Metabolism and Energy Expenditure. University of Texas Health Science Center – San Antonio, November 16-17, 2017, San Antonio, TX 66. Receptor Systems and Signaling Mechanisms in White and Brown Adipocytes. Bioenergetic and Metabolic Disease, Keystone Symposia, January 2018, Keystone CO