Immunology and Inflammation
Inflammation is a critical, signal-mediated response to potential signs of danger and damage. While acute inflammation is important to the immune response, chronic, inappropriate inflammation can cause tissue destruction and lead to disease (e.g., allergies, autoimmune disorders). Cayman offers a wide range of tools to help you study the factors related to innate and adaptive immune responses. · Assays and mass spec standards for the quantification of bioactive lipids · Corticosteroid receptor agonists, mast cell stabilizers, and antihistamines · Tools to study citrullination and carbamylation · TLR and chemokine receptor modulators and NETosis assays LOOK INSIDE TO LEARN MORE · Immunopeptidome profiling services Page 1 mast cell allergen eosinophil target protein Inflammatory IgE Lipid Mediators PAD Page 2 cytokines citrullinated CysLTs cytokines protein Allergy & Asthma PGs CysLTs histamines ACPA Page 3 histones Autoimmunity neutrophil LL-37 NE MPO Page 4 · Immunotherapeutics LTB 4 · Adaptive Immunity receptor TLR T cell PAMPs Page 5 SPMs T cell Innate Immunity receptor
MHC Page 7
COOH · Infectious Disease macrophage · Immunosuppressants DHA (DPA or EPA or AA) APC
The cellular environment during infection (or allergen exposure), immune activation, and subsequent inflammation involves a highly complex and well-coordinated team of mediators. This includes mast cells that react to danger by releasing histamines, pro-inflammatory cytokines, and eicosanoids and neutrophils/eosinophils that respond to these signals with an antimicrobial arsenal that involves NETs. Certain protein modifications, like citrullination, can alter self-epitopes and elicit an autoantibody response via T cells. Professional APCs, such as macrophages, activate T cells by displaying a MHC. SPMs, byproducts of DHA and other fatty acids, are generated later to initiate the resolution of inflammation.
2019 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM Inflammatory Lipid Mediators
Cayman offers a wide range of tools to study biochemical mediators released during the inflammatory process. Our core business is built around the production of bioactive lipids, including the manufacture of high-purity lipid standards and assays for their measurement, as well as biochemicals to disrupt key eicosanoid mediator production or signaling. We lead the industry as a resource for prostaglandins, leukotrienes, and specialized pro-resolving mediators pertinent to the study of immune activation and inflammation.
Leukotrienes Specialized Pro-Resolving Mediators Item No. Product Name Item No. Product Name
20110 Leukotriene B4 90410 Lipoxin A4
520111 Leukotriene B4 ELISA Kit* 590410 Lipoxin A4 ELISA Kit
120114 BLT 1 Receptor Polyclonal Antibody 90415 15(R)-Lipoxin A4
20210 Leukotriene C4 90420 Lipoxin B4
20310 Leukotriene D4 10878 Maresin 1
20410 Leukotriene E4 501150 Maresin 1 ELISA Kit
501060 Leukotriene E4 ELISA Kit 16369 Maresin 2
500390 Cysteinyl Leukotriene ELISA Kit* 17007 MCTR1
20001 Cysteinyl Leukotriene HPLC Mixture I 17008 MCTR2
20002 Cysteinyl Leukotriene HPLC Mixture II 19067 MCTR3
120500 CysLT 1 Receptor Polyclonal Antibody 19064 PCTR1
14713 CysLT 1 Receptor Polyclonal FITC Antibody 10010390 Protectin D1
10012554 Resolvin D1 Prostaglandins 13060 17(R)-Resolvin D1 Item No. Product Name 500380 Resolvin D1 ELISA Kit 501001 tetranor-PGDM ELISA Kit 10007279 Resolvin D2 12010 Prostaglandin D2 501120 Resolvin D2 ELISA Kit 512031 Prostaglandin D2 ELISA Kit* 13834 Resolvin D3 512011 Prostaglandin D2-MOX ELISA Kit* 13835 Resolvin D4 14010 Prostaglandin E2 10007280 Resolvin D5 314010 Prostaglandin E2-d4 18702 SPM D-series LC-MS Mixture 514010 Prostaglandin E2 ELISA Kit - Monoclonal* 10007848 Resolvin E1 516521 11β-Prostaglandin F2α ELISA Kit Common SPMs listed; methyl ester forms, internal standards, and LC-MS mixtures *Also available: express kits also available
COOH COOH COOH COOH
AA (90010) DPA (90165) DHA (90310) EPA (90110)
www.caymanchem.com 45 2 Request the full Specialized 15 5 2 15 COOH
OOH
COOH COOH
COOH COOH OOH 18(R)-HpEPE *15(S)-HpETE (44720) *5(S)-HpETE (44230) OOH 5 HOO 13(R)-HpDPA OH 5 COOH
OOH HOO 17(S)-HpDHA (13185) COOH OH Pro-Resolving Mediators wall poster at COOH 10(S),17(S)-DiHDHA (PDX) (10008128) COOH
OOH
*5(S),15(S)-DiHpETE COOH O COOH 18(R)-HEPE HO Resolvin E3 OH HO 13(R)-HDPA OH 16(S),17(S)-epoxy Protectin 5
O COOH
O OH OH OH OH OOH NH OH COOH COOH COOH OH COOH www.caymanchem.com/Literature OH COOH HO H2N O S *5(S),6(S)-epoxy-15(S)-DiHETE COOH NH COOH
OH Resolvin T4 (18440) COOH 5(S)-hydroperoxy- Resolvin T1 (18437) Resolvin E2 (13827) OH Protectin D1/Neuroprotectin D1 (10010390) OH PCTR1 (19064) 18(R)-HEPE
OH
HO OH OH OH OH COOH COOH COOH OH COOH OH
H N H N 2 2 O OH OH COOH OH HO OH O S HOOC S HO OH OH COOH OH NH COOH COOH Lipoxin A4 (90410) Lipoxin B4 (90420) OH (15(R)-Lipoxin A4, 90415) COOH Resolvin E1 (10007848) Resolvin T2 (18438) Resolvin T3 (18439) PCTR2 (19065) Protectin Family PCTR3 (19066) OH 5(S),6(S)-epoxy- 18(R)-HEPE *Have not been shown to have pro-resolving properties in published literature COOH HOO COOH
5 15
12 15 HOO 1 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108HO · USA · (800) 364-9897 17(S)-HpDHA (13185) WWW.CAYMANCHEM.COM 4(S)-hydroperoxy- 17(S)-HDHA 5
COOH
O O HOO OH OOH O COOH COOH COOH COOH COOH HO 13(S),14(S)-epoxy-Maresin 14(S)-HpDHA 14(S),20(R)-DiHDHA (19139) HO
4(S),5(S)-epoxy- 7(S),8(S)-epoxy- 7(S)-hydroperoxy- 17(S)-HDHA HO 17(S)-HDHA HO 17(S)-HDHA O HOOC NH NH H HOOC 2 N S
HO COOH O HOOC OH OH HO COOH HO OH OH HO COOH OH COOH COOH HO COOH OH MCTR1 (17007) OH HO HO HO OH HO OH Resolvin D3 (13834) Resolvin D4 (13835) Resolvin D2 (10007279) Resolvin D1 (10012554) Resolvin D5 (10007280) COOH NH COOH (17(R)-Resolvin D1, 13060) 2 Resolvin D6 (10484) H HOOC N S 14(S)-HDHA (15253) O OH OH
OH COOH SPECIALI ED PRO-RESOL ING MEDIATORS Maresin 1 (10878) MCTR2 (17008) The resolution of inflammation is an active process that is driven by unique signaling molecules. An important group of these specialized pro-resolving NH HO 2 mediators (SPMs) is derived from polyunsaturated fatty acids (arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and S docosahexaenoic acid (DHA)) that are liberated during the inflammatory process. Studies have demonstrated that these SPMs, which include resolvins, HOOC OH lipoxins, maresins, and protectins, evoke cellular and tissue responses that help conclude an inflammatory episode. Moreover, the addition of nanomolar OH COOH COOH concentrations of SPMs to an inflammatory milieu can have profound effects, such as reducing leukocyte infiltration, enhancing phagocytosis, and OH OH Maresin 2 (16369) MCTR3 (19067) reducing pain. Cayman Chemical, a leader in the synthesis of lipid mediators, offers an array of SPMs to help make your research possible. COOH 14(S),21(R)-HDHA Allergy & Asthma
Immune activation and inflammation are both characteristics of an allergic or asthmatic response. Cayman’s line of allergy and asthma research products includes tools for measuring and disrupting eicosanoid mediators and assays to assess ovalbumin-induced immune responses. Key corticosteroid receptor agonists, mast cell stabilizers, histamine receptor antagonists/inverse agonists, phosphodiesterase inhibitors, and β-adrenergic receptor agonists are also available.
DiHOMEs: Potential drivers of allergic responses and thermogenic activity Dihydroxy metabolites of linoleic acid may be biomarkers (±)9(10)-DiHOME ELISA Kit for the development of asthma and important mediators Item No. 501710 of fatty acid metabolism. Cayman offers competitive ELISAs to quantify 9(10)-DiHOME and 12(13)-DiHOME (±)12(13)-DiHOME ELISA Kit in plasma and serum. Item No. 501720 Corresponding unlabeled and deuterated standards for EpOMEs and DiHOMEs are also available for quantification by mass spec
Ovalbumin Assay Kits β-Adrenergic Receptor Agonists Item No. Product Name Item No. Product Name
500840 Anti-Ovalbumin IgE (mouse) ELISA Kit 14985 Clenbuterol (hydrochloride)
500830 Anti-Ovalbumin IgG1 (mouse) ELISA Kit 15584 Formoterol (hemifumarate)
16009 Salmeterol (xinafoate) Corticosteroid Receptor Agonists Over 10 β-adrenergic receptor agonists available online Item No. Product Name Antihistamines 15407 Budesonide Item No. Product Name 20739 Hydrocortisone 16967 Astemizole 18026 Triamcinolone acetonide 14637 Clemastine (fumarate) Over 10 corticosteroid receptor agonists available online 15625 Loratadine Mast Cell Stabilizers 14615 Meclizine (hydrochloride) Item No. Product Name Over 30 histamine receptor antagonists and/or inverse agonists available online 22173 Compound 48/80 (hydrochloride) 21379 Cromolyn (sodium salt hydrate) Conveniently Detect Histamine 23994 Lodoxamide Histamine EIA Kit - Item No. 589651 Phosphodiesterase Inhibitors · Measure histamine in plasma, serum, Item No. Product Name bronchoalveolar lavage, tissue extracts, and 14832 Ibudilast cell culture supernatant samples
15141 Roflumilast · Assay 33 samples in duplicate
10011132 Rolipram · Incubation: Overnight
10008671 Sildenafil Manufactured by Bertin Bioreagent Over 10 PDE inhibitors as well as related adenosine receptor antagonists available online
WWW.CAYMANCHEM.COM CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 2 Autoimmunity
Autoimmune disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are tied to post-translational modifications of proteins, specifically citrullination and carbamylation. Cayman offers a unique collection of tools to study citrullination and carbamylation. This includes citrullinated histones and citrullinated human fibrinogen as well as key detection antibodies. Protein arginine deiminase (PAD) ELISAs, recombinant proteins, antibodies, and inhibitors are also available.
Citrullinated Histones and Related Reagents Citrullinated Fibrinogen and Related Reagents Item No. Product Name Item No. Product Name
20582 Citrullinated Core Histones (bovine) 18473 Human Fibrinogen (PAD2 Citrullinated)
17926 Citrullinated Histone H3 (human recombinant) 400076 Human Fibrinogen (PAD4 Citrullinated)
501620 Citrullinated Histone H3 (Clone 11D3) ELISA Kit 501270 Anti-Citrullinated Human Fibrinogen Assay Kit (mouse)
18073 Histone H1.4 (Citrullinated R53) Polyclonal Antibody 23000 Citrullinated α-Enolase Monoclonal Antibody (Clone 8D3)
17939 Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody 17088 Citrullinated Fibrinogen Monoclonal Antibody (Clone 10E9.3)
17855 Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody 22054 Citrullinated Vimentin Monoclonal Antibody (Clone 12G11)
Detect Carbamylated Proteins Anti-Carbamylation (Homocitrulline) Polyclonal Antibody - Item No. 22428 Specifically detects carbamylated proteins of any type and from any species Also available: Anti-Carbamylation (Homocitrulline) Monoclonal Antibody (Item No. 23203) and carbamylation reagents
PAD Inhibitors PAD ELISAs Item No. Product Name Item No. Product Name
17079 BB-Cl-Amidine 501450 PAD2 (human) ELISA Kit
17489 GSK199 (hydrochloride) 501460 PAD4 (human) ELISA Kit
17488 GSK484 (hydrochloride) 500930 PAD4 Autoantibody ELISA Kit
17731 YW3-56 (hydrochloride, technical grade) PAD Monoclonal Antibodies Recombinant PAD Proteins Item No. Product Name Item No. Product Name 22997 PAD1 Monoclonal Antibody (Clone 6B4)
10784 PAD1 (human recombinant) 19822 PAD2 Monoclonal Antibody (Clone 9F7)
10785 PAD2 (human recombinant) 24377 PAD3 Monoclonal Antibody (Clone 4E5)
10786 PAD3 (human recombinant) 19671 PAD4 Monoclonal Antibody (Clone 11F9)
10500 PAD4 (human recombinant) 19669 PAD4 Monoclonal Antibody (Clone 6D8)
Screening Assays for Identifying Inhibitors of PAD Activity A set of assays to enable the screening of large libraries of compounds for the next generation of PAD inhibitors Also available: Assay kits for PAD1, 2, 3, and 4 in ammonia and AMC formats
3 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM Immunotherapeutics
Cayman offers Human Therapeutic IgG1, IgG2, and IgG4 ELISA Kits for use in accurately measuring human IgG species in monkey or rodent plasma and serum. These assays can help distinguish experimentally introduced human IgG from endogenous monkey IgG when assessing the pharmacokinetics of human therapeutic antibodies in monkey serum.
Validated ELISA kits for pharmacokinetic analysis of therapeutic human antibodies · Specifically detect human IgG1, IgG2, or IgG4 antibodies in monkey plasma or serum without prior sample purification · Not cross reactive to rhesus or cynomolgus immunoglobulins · Pharmacokinetic analysis of therapeutic human IgG1, IgG2, or IgG4 antibodies in monkeys · Detect human IgG1, IgG2, or IgG4 in mouse or rat plasma or serum
Human Therapeutic IgG1 Human Therapeutic IgG2 Human Therapeutic IgG4 ELISA Kit - Item No. 500910 ELISA Kit - Item No. 500960 ELISA Kit - Item No. 500920 Assay Range: 3.13-200 ng/ml Assay Range: 3.13-200 ng/ml Assay Range: 7.8-500 ng/ml LLOQ = 3.13 ng/ml LLOQ = 3.13 ng/ml LLOQ = 7.8 ng/ml Adaptive Immunity Immunopeptidome Profiling Services Cayman, in partnership with MS Bioworks, has optimized a workflow to enable MHC Class I and MHC Class II Associated Peptide Proteomics (MAPPs). Our collective expertise provides efficient, cost-effective deep sequence analysis of immunogenic peptides from tumor cells and biological therapeutics. · Identification of thousands of MHC-associated peptides · Allele-specific studies matched to your specifications · Analysis using Orbitrap MS and unbiased, deep sequencing of the MHC peptidome · Customized antibody production, cell culture, and bioanalysis
MHC Class I MHC Class II
MHC Peptides LYSIS
m/z
CELLS OR TISSUE MHC IP PEPTIDE ELUTION ORBITRAP LC-MS/MS DATA ANALYSIS
WWW.CAYMANCHEM.COM CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 4 Innate Immunity
Innate immunity is a key defense system activated in response to bacterial and viral infections. Cayman offers a collection of tools to study host defense mechanisms that includes chemokine receptor and toll-like receptor modulators, phagocytosis and neutrophil extracellular trap assays, and proteins involved in STING signaling and the induction of the type 1 interferon (IFN) response.
Chemokine Receptor Modulators Phagocytosis Assay Kits Item No. Product Name Item No. Product Name
27633 AZD 2098 500290 Phagocytosis Assay Kit (IgG FITC)
11479 Bindarit 601480 Phagocytosis Assay Kit (IgG-DyLight™ 405)
28421 BMS 813160 601490 Phagocytosis Assay Kit (IgG-DyLight™ 633)
18503 BX 471 600540 Phagocytosis Assay Kit (IgG PE)
21885 CCR4 Antagonist (hydrochloride) 601370 E. coli Phagocytosis Assay Kit
23927 Cenicriviroc CD36 Scavenger Receptor Antibodies 28433 INCB 3344 Granule Contents Item No. Product Name NET Involvement in Sepsis
Endothelial 14641 Maraviroc · Calgranulin NEUTROPHIL BIOLOGY damage · Cathepsin G · Defensins 188150 CD36 Monoclonal Antibody (Clone JC63.1) · Elastase (NE) Lytic versus Vital NETosis Organ · Lactoferrin damage 21803 MK-0812 · Leukocyte proteinase (PR3) Lytic NETosis: Thrombosis · LL-37 · NADPH activation/ROS · Plasma membrane rupture · Myeloperoxidase (MPO) 10009893 CD36 Monoclonal· PAD activation Antibody· NETs released (Clone JC63.1) (azide free) · Nuclear envelope disassembly · Neutrophil dies · Chromatin decondensation 21492 Reparixin (L-Lysine salt) Bacterial sequestration Complement Vital NETosis: Autoantigen immune 10009870 CD36 Monoclonal· PAD activation FITC Antibody (Clonecomplexes ANCA JC63.1) · Chromatin decondensation ACPA · NETs expelled via vesicles Anti-dsDNA Components Expelled During NETosis · Neutrophil remains alive as Rheumatoid Arthritis (RA) Progression functional anuclear cytoplast 13336 SB 225002 B cell 100011 CD36 Polyclonal Antibody PAD · Azurocidin · Histones Viruses Citrullination · Calprotectin · Lactoferrin · Cathelicidins · Leukocyte Citrullinated human joint proteins 11974 TC 14012 (trifluoroacetate salt) · Cathepsin G proteinase (PR3) Joint · Lysozyme C inflammation · Defensins Parasites Complement receptors Self-Antigen · Mitochondrial DNA · Elastase (NE) Presentation Perpetuation · Gelatinase · Myeloperoxidase (MPO) CD4+ T cell of inflammation · Genomic DNA leading to Over 20 chemokine receptor agonists, antagonists, and inverse agonists available online chronic RA
Autoantigen immune complexes
TLR Th1/Th17 cytokines Triggers of NET Formation NET-Associated Thrombosis · Activated platelets · Hydrogen peroxide Antibodies · Autoantibodies (substrate of MPO) Degradation & Removal Platelet activation · Bacteria · Interleukin-8 (IL-8) Tissue factor Thrombin activation Fibrin clot formation · Cholesterol crystals · Ionophores (A23187, Nigericin) Deposition & damage · Cigarette smoke · Lipid mediators Fc receptors Request a copy of our Neutrophil· Complement-derived (2-chloro fatty acid [2-CI FA]) peptides · Protozoa Ca2+ NE cit cit NE · Endotoxins O O (bacterial component, LPS) · Urate crystals O · Fungi · Viruses O H H MPO MPO MPO H PMA OH Macrophage 2+ PAD O HO Ca NADPH oxidase Biology wall poster for your lab at OH activation MPO ROS NE ROS
2+ PAD Modifies Arginine to Citrulline Ca Serum Nucleases NET-Assisted Cancer Metastasis www.caymanchem.com/literature Integrins Cancer- + Citrullination Targets: Disseminated associated H N NH H N O 2 2 2 · β-Catenin cancer cell thrombosis H O · Cytokeratin NH 2 NH Activated · α-Enolase TLR4 PAD Platelets NETs trap cancer cells · Fibrinogen IL-18 and assist in extravasation Ca2+ NH + 4 · Filaggrin ROS · Heat shock proteins Systemic/chronic Protein Protein inflammation · Histones Macrophage · Vimentin Direct Peptidyl Arginine Peptidyl Citrulline IL receptor Neutrophil Extracellular Traps (NETs) release(+ charge) DNA,(neutral) · and mor histones,e! and other antimicrobial componentsStimulation IL-1β G-CSF Stromal weakening Priming and and degradation reduced activation Bacteria T cell threshold
extracellularly to capture and kill pathogens.PAD F eedbackThis Loop may Halts be initiated by respiratory burst, MPO-induced chromatin Anti-Inflammatory Role of Respiratory Burst Neutrophil Phagocytosis Aggregated NETs
Ca2+ NADPH NADPH Microbe Type I oxidase oxidase Specific Plasmacytoid interferons decondensation, or histone deimination. If not cleared properly, NETs can be a targetgranules ofInternalized autoantibody microbes are formation. destroyed by the respiratory burst Dendritic Cell Cytokines (ROS produced by NADPH Rac Phagosome oxidase) and by fusion of the phagosome with granules. This Pro-inflammatory NCF2 Rac NCF4 process can result in neutrophil cytokines NCF2 Myeloid NCF1 PAD NCF4 apoptosis, resolving inflammation, cit ROS Dendritic Cell Pro-inflammatory ROS Azurophilic or necrosis, promoting further Antibodies Assay Kits granules cytokines NCF1 inflammation, depending on the cit PAD pathogen ingested.
Activated NADPH oxidase associated Calcium influx activates PAD to Sequestered and with PAD produces ROS citrullinate NCF proteins, which proteolytically degraded Aggregated NETs dissociate and inhibit ROS Special thanks to Dr. Cameron Louttit from the University of Michigan cytokines Item No. Product Name DepartmentItem of Biomedical Engineering No.for consultation on this diagram. Product Name © 2019 Cayman Chemical
15635 dsDNA Monoclonal Antibody (Clone 2C4) 501410 Myeloperoxidase (human) ELISA Kit
Histone H3.3 Polyclonal Antibody 601010 NETosis Assay Kit 13784 (Also available: 13535, 13543) 600610 Neutrophil Elastase Activity Assay Kit 15637 LL-37 Polyclonal Antibody 600620 Neutrophil Myeloperoxidase Activity Assay Kit 15641 Lysozyme C Monoclonal Antibody (Clone 4C3) 601130 Neutrophil/Monocyte Respiratory Burst Assay Kit Myeloperoxidase (mouse) Polyclonal Antibody 20493 (Also available: 15638, 15640) 601070 Neutrophil (mouse) Isolation Kit
5 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM STING and Interferon Induction Monitor second messenger 2’3’-cGAMP in cells 2'3'-cGAMP ELISA Kit - Item No. 501700 · Measure 2'3'-cGAMP in cell lysates down to 85.3 pg/ml · Monitor the kinetics of 2'3'-cGAMP formation and hydrolysis · Identify compounds that modulate cGAS activity by monitoring cGAMP levels Powered by
STING Variants Item No. Product Name
22816 STING R232 variant (human recombinant)
22815 STING H232 variant (human recombinant)
15139 STING H232 variant; SUMO-tagged (human recombinant)
23592 STING AQ variant (human recombinant)
23594 STING M284 variant (human recombinant)
23593 STING R224 variant (human recombinant)
25306 STING A162 variant (human recombinant)
Read about how amino acid variations affect innate immune response to foreign STING dimer (A and B are both aa 139-379) bound to cyclic di-GMP and notated DNA at www.caymanchem.com/STINGvariants with key amino acid modifications of Cayman's STING variants. Upstream/Downstream Proteins in the STING Pathway cGAS, STING, IRF3, and IKKγ Antibodies Item No. Product Name Item No. Product Name
22810 cGAS (human recombinant) 23853 cGAS Monoclonal Antibody (Clone 5G10)
25001 cGAS (161-522) (human recombinant) 17856 STING Monoclonal Antibody (Clone 2C8) CdnP (Mycobacterium tuberculosis strain ATCC 25618/ 22809 17857 STING Polyclonal Antibody H37Rv recombinant) 24791 STING M284 variant Polyclonal Antibody 22817 TBK1 (human recombinant) 24937 IRF3 Polyclonal Antibody 22811 IRF3 (human recombinant) 13931 IKKγ Monoclonal Antibody (Clone 72C627) 23590 IRF3 (S386A, S396A mutant; human recombinant)
Toll-Like Receptors Antibodies Agonists and Pathogen-Associated Molecular Patterns Item No. Product Name Item No. Product Name
13582 Toll-Like Receptor 1 Polyclonal Antibody 14956 Imiquimod
13587 Toll-Like Receptor 2 Monoclonal Antibody (Clone TL2.1) 19661 LPS from Escherichia coli O111:B4
13589 Toll-Like Receptor 4 Monoclonal Antibody (Clone HTA125) 24126 Pam3CSK4 (trifluoroacetate salt)
13593 Toll-Like Receptor 9 Monoclonal Antibody (Clone 26C593.2) 14806 R-848
Additional antibodies are available online Additional agonists and inhibitors are available online
WWW.CAYMANCHEM.COM CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 6 Infectious Disease
Cayman provides a diverse set of antimicrobial and antiviral agents, many of which are derived from natural resources, that can be used to study the treatment, prevention, and/or antibiotic resistance of infectious diseases and other health challenges. This important set of tools can be used to further understand the growth cycle of harmful microbes and key signaling pathways, including how the body's immune response system works to eliminate infections.
Antibiotics Antivirals Item No. Product Name Item No. Product Name
15305 A-54556A 21065 N-Butyldeoxynojirimycin (hydrochloride)
14417 Ampicillin (sodium salt) 22191 Dolutegravir
15004 Azithromycin 10009197 Flavopiridol (hydrochloride)
14422 Doxycycline (hyclate) 11208 KRN 7000
16488 Monensin (sodium salt) 14641 Maraviroc
20766 Piperacillin (sodium salt) 15144 Nelfinavir (mesylate)
14157 Polymyxin B (sulfate) 10011332 Plerixafor (hydrochloride hydrate)
17185 Tazobactam (sodium salt) 22411 Procyanidin B1
15327 Vancomycin (hydrochloride) 11974 TC 14012 (trifluoroacetate salt)
Common antibiotics listed, over 655 antibiotics available online Common antivirals listed, over 320 available online Immunosuppressants
Immunosuppressive agents are designed to limit the Potent Immunosuppressants production of inflammatory mediators, disrupt the Item No. Product Name
activation of T cells, prevent cell proliferation, and/or 15316 Auranofin impair the function of cell surface markers, thus inhibiting 12088 Cyclosporin A stimulation of T cells directed against foreign antigens. 10007965 FK-506 Cayman offers a targeted set of compounds that can be used to study these various therapeutic strategies 63150 Myriocin for application in organ transplant survival as well as 13346 Rapamycin diseases with an inflammatory component. 10007974 SLF Common immunosuppressants listed, 40 available online
Contact Us PHONE (800) 364-9897 (USA and Canada only) EMAIL Sales: [email protected] (734) 971-3335 Customer Service: [email protected] Technical Support: [email protected] FAX (734) 971-3640 Contract Services: [email protected] WEB www.caymanchem.com ADDRESS 1180 E. Ellsworth Rd. · Ann Arbor, MI · 48108 · USA
2019 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM