Did You Know... Inhalants

Total Page:16

File Type:pdf, Size:1020Kb

Did You Know... Inhalants · Serious health problems: People who use solvents · Weakened immune system: Recent animal research Some long-term effects may be reversible, but others One in a series… regularly for a long time can damage their liver, shows that nitrites may impair the immune system are permanent. When inhaled, solvents are carried by Alcohol Hallucinogens Do You Know... kidneys, lungs, heart, brain, bones and blood. that protects against infectious diseases. the blood and stored in fat tissue in the body. Internal Alcohol, Other Drugs Heroin Sometimes this damage heals when drug use is organs that have high blood circulation and that are and Driving Inhalants stopped; sometimes it is permanent. Are inhalants addictive? rich in fat tissue, such as the brain, liver and kidney, Amphetamines They can be. are particularly affected. If inhalant use is stopped, Ketamine Anabolic Steroids · Fetal solvent syndrome: Use of solvents during damage to the liver and kidneys may heal, but damage LSD pregnancy, especially chronic use, can result in Most inhalant use is experimental and occasional. Benzodiazepines Street names: glue, gas, sniff (solvents); whippets (nitrous to the brain is almost always permanent. Studies using Methadone However, people who use inhalants regularly can Caffeine oxide); poppers, room odourizers, VCR cleaner — some sold premature birth, birth defects or stillbirth. scans of people’s brains after chronic long-term solvent under “brand” names such as Rush, Bolt, Kix (nitrites) develop “tolerance.” This means that more and more Methamphetamine use show that solvent use can cause the brain to Cannabis Nitrous oxide of the substance is needed to produce the same Inhalants atrophy, or shrink, which can severely affect thinking, Cocaine Opioids What are inhalants? effects. Regular use also leads to a persistent craving memory and movement control. Ecstasy Rohypnol The term “inhalants” refers to chemical · Lack of oxygen: Sniffing pure nitrous oxide starves for the high, which makes it hard to stop using. When GHB Tobacco vapours or gases that produce a “high” when the body of oxygen. Some people have died this way. regular use is stopped, withdrawal symptoms may Inhalant use can also result in permanent hearing loss they are breathed in. Most of the substances include nausea, loss of appetite, tremors, anxiety, · Loss of motor control: People who use nitrous oxide and damage to bone marrow. used as inhalants, such as glue, gasoline, depression and paranoia. while standing can fall and hurt themselves. cleaning solvents and aerosols, have legitimate everyday uses, but they were never What are the long-term effects of using For more information on addiction and mental health issues, · Frostbite: The gas is extremely cold as it is released inhalants? or a copy of this brochure, please contact CAMH’s R. Samuel meant for human consumption. Inhalants are from the cylinder and can freeze skin. In addition, McLaughlin Addiction and Mental Health Information Centre: cheap, legal and easy to get. They have a high The long-term effects of inhalants vary depending on ONTARIO TOLL-FREE:1 800 463-6273 pressure in the tank can damage the lungs. potential for abuse — especially by children which inhalant is used. Some of the possible effects TORONTO: 416 595-6111 and young adults. are bloodshot eyes, sores on the nose and mouth, · Nerve damage: High levels of nitrous oxide use, even To order multiple copies of this brochure, or other CAMH nosebleeds, pale skin, excessive thirst and weight loss. resource materials, please contact: with adequate oxygen, has been shown to damage Marketing and Sales Services There are hundreds of different kinds of People who use inhalants over a long term may also TEL.: 1 800 661-1111 or 416 595-6059 in Toronto nerves. This can cause numbness, weakness and loss inhalants, roughly dividing into four different be confused, tired, depressed, irritable, hostile and E-MAIL: [email protected] of balance. types: paranoid and have trouble concentrating, remembering To make a donation, please contact: Nitrites and thinking clearly. Heavy solvent use can result Centre for Addiction and Mental Health Foundation TEL.: 416 979-6909 · Volatile solvents: These are the most in numbness, weakness, tremors and a lack of co- E-MAIL: [email protected] commonly abused type of inhalants. · Unsafe sexual practices: An increased risk of ordination in the arms and legs. If you have questions, compliments or concerns “Volatile” means they evaporate when contracting HIV and hepatitis is associated with about services at CAMH, please call our exposed to air, and “solvent” means they nitrite use. Client Relations Co-ordinator at: TEL.: 416 535-8501 ext. 2028 dissolve many other substances. Examples Visit our Web site at: www.camh.net of solvents used as inhalants include benzene, toluene, xylene, acetone, naptha Copyright © 2003 Centre for Addiction and Mental Health and hexane. Products such as gasoline, A Pan American Health Organization / World Health Organization Collaborating Centre Affiliated with the University of Toronto Disponible en français 2502 / 02-04 P259 cleaning fluids, paint thinners, hobby glue, correction What do inhalants look like, and how are An ongoing survey of drug use among Ontario students Inhaled solvents usually produce an alcohol-like effect, Are inhalants dangerous? fluid and felt-tip markers contain a mixture of different they used? in grades 7 to OAC reported that student use of but with more distortion of perception, such as the Yes. Inhalant use is dangerous in many ways: types of solvents. Solvent and aerosol products — on the store shelf, in solvents one or more times in the past year increased shape, size and colour of objects, and distortion of the kitchen cupboard or in the workshop — would not from 2.6 per cent in 1997 to 7.3 per cent in 1999 time and space. New users may be initially excited, Solvents and aerosols · Aerosol or spray cans: Hair spray, spray paint, cooking be noticed by most people as dangerous drugs. and decreased to 5.9 per cent in 2001. then become drowsy and fall asleep. People who use spray and other aerosol products contain pressurized solvents more often may feel euphoric, exhilarated and · Suffocation: Solvents are often sniffed from a plastic bag, which is held firmly around the nose and mouth. liquids or gases such as fluorocarbon and butane. When solvents are used as drugs, they are either inhaled Nitrous oxide is a drug of abuse available to many have vivid fantasies. Some feel giddy, outgoing and People who use solvents sometimes pass out with the Some aerosol products also contain solvents. directly from the container (“sniffed”), from a soaked rag health care workers. Nitrous oxide appears to be confident. Physical effects may include dizziness, bag still in place, and suffocate due to lack of held to the face (“huffed”) or from a bag (“bagged”). gaining popularity among young adults. nausea, vomiting, blurred vision, sneezing and oxygen. Choking on vomit when unconscious is · Gases: This includes some medical anesthetics, Sometimes people spray aerosols into a bag or balloon coughing, staggering, slow reflexes and sensitivity to another major cause of inhalant-related death. such as nitrous oxide (“laughing gas”), chloroform, and then inhale the gas. Nitrite use is most common among gay men, although light. halothane and ether, as well as gases found in U.S. statistics indicate that the rate of nitrite use has · Recklessness: Sniffing reduces inhibition and affects commercially available products, such as butane Nitrous oxide or other anesthetic gases intended for fallen. Nitrous oxide produces a dreamy mental state, loss of the way people feel about themselves and the world lighters and propane tanks. medical use are contained in a gas tank; nitrous oxide motor control, hallucinations and an increased around them. It makes some people feel powerful, is also found in whipped cream dispensers. Because How do inhalants make you feel? threshold for pain. which has led to dangerous and destructive behaviour · Nitrites: Amyl nitrite, butyl nitrite and cyclohexyl nitrite nitrous oxide is pressurized and can be very cold, it How inhalants, or any drugs, affect you depends on that caused serious harm. Others don’t get “high” (also known as “poppers”) are different from other is often inhaled from a balloon. a number of factors: Nitrites dilate blood vessels and relax muscles. The when they sniff; they get depressed. Self-destructive inhalants in effect and availability. They are sold as · your age heartbeat quickens and blood rushes to the head, or suicidal behaviour are common among people who “room odourizer” or “video head cleaner.” Amyl nitrite Nitrites are clear yellow liquids that are inhaled directly · how sensitive you are to the drug creating a “rush.” Nitrites also cause headaches, use solvents. is used medically to treat cyanide poisoning; butyl from the bottle or from a cloth. · how much you use dizziness, nausea and flushing. Some men use nitrites · how long and how often you’ve been using it nitrite is an illegal substance in the United States. during sex for the drugs’ capacity to relax muscles Most inhalants are highly flammable; recklessness · the method you use to take the drug Who uses inhalants? and promote blood flow. with lit cigarettes and flames while using inhalants · the environment you’re in Where do inhalants come from? Most of the people who use solvents and aerosols are has caused tragic accidents. Many inhalants are widely available as commercial young — between 10 and 16 years old. Many try · whether or not you have certain pre-existing medical How long does the feeling last? products. It is hard to prevent their use because these inhalants only once or twice, or use them only on or psychiatric conditions Several breaths of solvents will produce a high within · Sudden sniffing death (SSD): Prolonged sniffing of products are found in many homes and workplaces.
Recommended publications
  • Inhalants Booklet6/4/0712:04Ampage1 Inhalants Inhalants Booklet 6/4/07 12:04 AM Page 2
    inhalants booklet6/4/0712:04AMPage1 inhalants inhalants booklet 6/4/07 12:04 AM Page 2 inhalants WHAT ARE INHALANTS? Inhalants are a range of products that are sniffed or inhaled to give the user an immediate head rush or ‘high’. These substances are easily absorbed through the lungs and carried to the brain, where they act to slow down the central nervous system. Many familiar household products are inhalants. Some of the most common are: • Glue • Aerosol spray cans • Cleaning fluids • Felt-tipped pens • Correction fluid (liquid paper) • Chrome-based paints • Paint or paint thinner • Petrol • Anaesthetics Many inhalants are classified as volatile solvents. These change rapidly from a liquid or semi-solid state to a gas when exposed to air. They include chemicals that are found in products such as deodorants, air fresheners, lighter fuels and propellant gases used in aerosols such as whipped cream dispensers. Some volatile solvents are inhaled because of the effects produced not only by the product’s main ingredient, but by the propellant gases, as in aerosols, such as hair spray. Other solvents found in aerosol products such as gold and silver spray paint are sniffed not because of the effects from propellant gases but because of the psychoactive effects caused by the specific solvents necessary to suspend these metallic paints in the spray. The sniffing of metallic paints is known as ‘chroming’. inhalants booklet 6/4/07 12:04 AM Page 3 Another category of inhalant is the nitrites. Amyl, butyl and isobutyl nitrite (collectively known as alkyl nitrites) are clear, yellow liquids which are inhaled for their intoxicating effects.
    [Show full text]
  • An Ecological Investigation of the Time Course of Hangover
    AN ECOLOGICAL INVESTIGATION OF HANGOVER SEVERITY AND TIME COURSE _______________________________________ A Dissertation presented to the Faculty of the Graduate School at the University of Missouri-Columbia _______________________________________________________ In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy _____________________________________________________ by ERIN HUNT-CARTER Dr. Thomas Piasecki, Dissertation Supervisor DECEMBER 2010 The undersigned, appointed by the dean of the Graduate School, have examined the dissertation entitled AN ECOLOGICAL INVESTIGATION OF HANGOVER SEVERITY AND TIME COURSE presented by Erin E. Hunt-Carter, a candidate for the degree of doctor of philosophy, and hereby certify that, in their opinion, it is worthy of acceptance. Professor Thomas M. Piasecki Professor Wendy S. Slutske Professor Kenneth J. Sher Professor Dennis K. Miller Professor Daniel C. Vinson Thank you to my wonderful husband, Brent. I would not have completed this without your endless encouragement and kindness. Thank you to my parents, Toni and John Hunt, and my parents-in-law, Sondra and Guy Carter. Their support and many hours of babysitting were invaluable. Thank you to my sister, Meghan Hunt, for being riotously funny and supporting me through this process. Finally, I’d like to thank my children, Ian and Anna Carter, for keeping me grounded and reminding me what is truly important in life. ACKNOWLEDGEMENTS It is a pleasure to thank those who made this dissertation possible. First, I would like to express my gratitude to my doctoral advisor, Dr. Thomas Piasecki. He generously welcomed me into his lab, and enabled me to gain invaluable experience with ecological momentary assessment. I could not have completed this dissertation without his patient advice, extensive knowledge, and encouragement.
    [Show full text]
  • Combined Exposure to Nicotine and Ethanol in Adolescent Mice Differentially Affects Anxiety Levels During Exposure, Short-Term, and Long-Term Withdrawal
    Neuropsychopharmacology (2008) 33, 599–610 & 2008 Nature Publishing Group All rights reserved 0893-133X/08 $30.00 www.neuropsychopharmacology.org Combined Exposure to Nicotine and Ethanol in Adolescent Mice Differentially Affects Anxiety Levels during Exposure, Short-Term, and Long-Term Withdrawal ,1 1 1 1 Yael Abreu-Villac¸a* , Fernanda Nunes , Fabı´ola do E Queiroz-Gomes , Alex C Manha˜es and 1 Cla´udio C Filgueiras 1 ˆ ˆ Laborato´rio de Neurofisiologia, Departamento de Ciencias Fisiolo´gicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biome´dico, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil Smoking and consumption of alcoholic beverages are frequently associated during adolescence. This association could be explained by the cumulative behavioral effects of nicotine and ethanol, particularly those related to anxiety levels. However, despite epidemiological findings, there have been few animal studies of the basic neurobiology of the combined exposure in the adolescent brain. In the present work we assessed, through the use of the elevated plus maze, the short- and long-term anxiety effects of nicotine (NIC) and/or ethanol (ETOH) exposure during adolescence (from the 30th to the 45th postnatal day) in four groups of male and female C57BL/6 mice: (1) Concomitant NIC (nicotine free-base solution (50 mg/ml) in 2% saccharin to drink) and ETOH (ethanol solution (25%, 2 g/kg) i.p. injected every other day) exposure; (2) NIC exposure; (3) ETOH exposure; (4) Vehicle. C57BL/6 mice were selected, in spite of the fact that they present slower ethanol metabolism, because they readily consume nicotine in the concentration used in the present study.
    [Show full text]
  • Caffeine and Adenosine
    Journal of Alzheimer’s Disease 20 (2010) S3–S15 S3 DOI 10.3233/JAD-2010-1379 IOS Press Review Article Caffeine and Adenosine Joaquim A. Ribeiro∗ and Ana M. Sebastiao˜ Institute of Pharmacology and Neurosciences, Faculty of Medicine and Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal Abstract. Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogenous adenosinergic tonus. Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors. Caffeine, through antagonism of ARs, affects brain functions such as sleep, cognition, learning, and memory, and modifies brain dysfunctions and diseases: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Epilepsy, Pain/Migraine, Depression, Schizophrenia. In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine. Keywords: Adenosine, Alzheimer’s disease, anxiety, caffeine, cognition, Huntington’s disease, migraine, Parkinson’s disease, schizophrenia, sleep INTRODUCTION were considered out of the scope of the present work. For more detailed analysis of the actions of caffeine in Caffeine causes most of its biological effects via humans, namely cognition, dementia, and Alzheimer’s antagonizing all types of adenosine receptors (ARs).
    [Show full text]
  • Inhalant Abuse Pediatric Care
    CLINICAL REPORT Guidance for the Clinician in Rendering Inhalant Abuse Pediatric Care Janet F. Williams, MD, Michael Storck, MD, and the Committee on Substance Abuse and Committee on Native American Child Health ABSTRACT Inhalant abuse is the intentional inhalation of a volatile substance for the purpose of achieving an altered mental state. As an important, yet-underrecognized form of substance abuse, inhalant abuse crosses all demographic, ethnic, and socioeco- nomic boundaries, causing significant morbidity and mortality in school-aged and older children. This clinical report reviews key aspects of inhalant abuse, empha- sizes the need for greater awareness, and offers advice regarding the pediatrician’s role in the prevention and management of this substance abuse problem. TYPES OF CHEMICALS AND PRODUCTS ABUSED The term “inhalant” encompasses a wide range of pharmacologically diverse substances that readily vaporize. Most other substances of abuse are classified by grouping together substances that share a specific central nervous system action or perceived psychoactive effect, but inhalant substances that are abused are grouped by having a common route of drug use. Inhalant abuse, sometimes referred to as solvent or volatile substance abuse, can be better understood when the expansive list of inhalants is classified into 3 groups on the basis of what is currently known pharmacologically: group I includes volatile solvents, fuels, and anesthetics; group II includes nitrous oxide; and group III includes volatile alkyl nitrites (Table 1). This classification is also consistent with reported differences in user populations, patterns of abuse, and associated problems seen clinically.1–3 Drugs that do not www.pediatrics.org/cgi/doi/10.1542/ readily vaporize at room temperature, such as cocaine, heroin, nicotine, or alcohol, peds.2007-0470 can also be abused through inhalation, but characteristic pharmacologic properties doi:10.1542/peds.2007-0470 distinguish these substances from inhalants.
    [Show full text]
  • Expectation Hangover “I Wish I’D Had This Step-By-Step Guide on How to Overcome Huge Obstacles When I Shattered Both My Wrist and My Dreams of Playing for the NFL
    Praise for Expectation Hangover “I wish I’d had this step-by-step guide on how to overcome huge obstacles when I shattered both my wrist and my dreams of playing for the NFL. Don’t let your Expectation Hangover control your life — apply what is in this book!” — Lewis Howes, former pro athlete turned lifestyle entrepreneur, host of The School of Greatness podcast “Christine Hassler is the kind of true spiritual guide we all need in our corner — soulful, wise, compassionate, and practical. Her proven methods and deep personal understanding are like the best medicine ever for your heart and soul.” — Christine Arylo, self-love catalyst and author of Madly in Love with ME: The Daring Adventure of Becoming Your Own Best Friend “Christine Hassler continues to be an invaluable voice for every generation. Her insights and observations have changed and enlightened the way I look at my life and the way I raise my children.” — Michael DeLuca, film producer and Columbia Pictures president of production “Disappointment can be a big, ugly monster hiding under our beds. This book is the go-to for getting us through Expectation Hangovers with grace and shining light to cast away those ugly creatures of disappointment!” — Kathryn Budig, author of The Women’s Health Big Book of Yoga “Christine Hassler is brilliant and insightful. Finally, here is the solution for dealing with something that plagues so many, myself included. If you’re hoping to thrive in a world that seems to hand out setbacks at every oppor- tunity, this is the book for you.
    [Show full text]
  • The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover
    Journal of Clinical Medicine Review The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover 1, 1,2, 1,3 1 Marlou Mackus y, Aurora JAE van de Loo y , Johan Garssen , Aletta D. Kraneveld , Andrew Scholey 4 and Joris C. Verster 1,2,4,* 1 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands; [email protected] (M.M.); [email protected] (A.J.v.d.L.); [email protected] (J.G.); [email protected] (A.D.K.) 2 Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands 3 Global Centre of Excellence Immunology, Nutricia Danone Research, 3584CT Utrecht, The Netherlands 4 Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia; [email protected] * Correspondence: [email protected]; Tel.: +31-30-2536-909 Both authors contributed equally to the manuscript. y Received: 31 August 2020; Accepted: 22 October 2020; Published: 25 October 2020 Abstract: The limited number of available studies that examined the pathology of alcohol hangover focused on biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol as potentially important determinants of hangover severity. The available literature on alcohol metabolism and oxidative stress is reviewed in this article. The current body of evidence suggests a direct relationship between blood ethanol concentration and hangover severity, whereas this association is not significant for acetaldehyde. The rate of alcohol metabolism seems to be an important determinant of hangover severity. That is, fast elimination of ethanol is associated with experiencing less severe hangovers.
    [Show full text]
  • Alcohol Withdrawal
    Alcohol withdrawal TERMINOLOGY CLINICAL CLARIFICATION • Alcohol withdrawal may occur after cessation or reduction of heavy and prolonged alcohol use; manifestations are characterized by autonomic hyperactivity and central nervous system excitation 1, 2 • Severe symptom manifestations (eg, seizures, delirium tremens) may develop in up to 5% of patients 3 CLASSIFICATION • Based on severity ○ Minor alcohol withdrawal syndrome 4, 5 – Manifestations occur early, within the first 48 hours after last drink or decrease in consumption 6 □ Manifestations develop about 6 hours after last drink or decrease in consumption and usually peak about 24 to 36 hours; resolution occurs in 2 to 7 days 7 if withdrawal does not progress to major alcohol withdrawal syndrome 4 – Characterized by mild autonomic hyperactivity (eg, tachycardia, hypertension, diaphoresis, hyperreflexia), mild tremor, anxiety, irritability, sleep disturbances (eg, insomnia, vivid dreams), gastrointestinal symptoms (eg, anorexia, nausea, vomiting), headache, and craving alcohol 4 ○ Major alcohol withdrawal syndrome 5, 4 – Progression and worsening of withdrawal manifestations, usually after about 24 hours from the onset of initial manifestations 4 □ Manifestations often peak around 50 hours before gradual resolution or may continue to progress to severe (complicated) withdrawal, particularly without treatment 4 – Characterized by moderate to severe autonomic hyperactivity (eg, tachycardia, hypertension, diaphoresis, hyperreflexia, fever); marked tremor; pronounced anxiety, insomnia,
    [Show full text]
  • Psychosocial Factors, Alcohol Use, and Hangover Signs Among Social Drinkers: a Reappraisal
    J Clin Epidemiol Vol. 46, No. 5, pp. 413422, 1993 0895.4356/93 $6.00 + 0.00 Printed in Great Britain. All rights reserved Copyright C 1993Pergamon Press Ltd PSYCHOSOCIAL FACTORS, ALCOHOL USE, AND HANGOVER SIGNS AMONG SOCIAL DRINKERS: A REAPPRAISAL ERNEST HARBURG,“‘* ROBERT GUNN,~ LILLIAN GLEIBERMAN,’ WAYNE DIFRANCEISCO’ and ANTHONY SCHORK~ ‘Department of Epidemiology, School of Public Health, 2Department of Psychology, ‘Department of Psychiatry, Veterans Administration Hospital and 4Department of Biostatistics, School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A. (Received in revised form 6 January 1993) Abstract-To reappraise a prior study of hangover signs and psychosocial factors among a sample of current drinkers, we excluded a subgroup termed Sobers, who report “never” being “tipsy, high or drunk.” The non-sober current drinkers then formed the sample for this report (N = 1104). About 23% of this group reported no hangover signs regardless of their intake level or gender, and the rest showed no sex differences for any of 8 hangover signs reported. Using multiple regression, including ethanol, age and weight, it was found that psychosocial variables contributed independently in predicting to hangover for both men and women in this order: (1) guilt about drinking; (2) neuroticism; (3) angry or (4) depressed when high/drunk and (5) negative life events. For men only, ethanol intake was also significant; for women only, being younger and reporting first being high/drunk at a relatively earlier age were also predictors of the Hangover Sign Index (HSI). These multiple predictors accounted for 5-10 times more of the hangover variance than rlcohol use alone: for men, R = 0.43, R2 = 19%; and for women, R = 0.46, R2 = 21%.
    [Show full text]
  • Sitmulants (Cocaine and Amphetamines)
    Treatment of Acute Intoxication and Withdrawal from Drugs of Abuse Adapted or excerpted from: The Textbook of Substance Abuse Treatment, second edition. Editors: Marc Galanter, MD and Herbert D Kleber, MD Sitmulants (Cocaine and Amphetamines) “The intoxicated person may show signs of hyperawareness, hypersexuality, hypervigialance, and psychomotor agitation. Often, the symptoms of stimulant-induced intoxication resemble mania. The intoxicated person should be monitored by the medical staff until the symptoms of intoxication diminish. If the intoxication does not return to baseline level within 24 hours, mania may be present, and treatment for manic discorder may be required. With increased dosage and duration of administration, stimulants can also produce a state of mental confusion and excitement know as stimulant delirium. Delirium is associated with becoming disoriented and confused as well as anxious and fearful. Extreme medical caution is needed when treating delirium because such symptoms may indicate stimulant overdose. For instance, patients addicted to crack cocaine who over-dose need careful monitoring for seizures, cardiac arrhythmias, stroke, and pulmonary complication. Overdose management has been reviewed in detail (see Gay, 1982: Ann Emerg Med 11:562-572), but more recently a syndrome of hyperthermia and agitation has been described that resembles neuroleptic malignant syndrome. Standard pharmaological management of overdose includes neuroleptics, but high doses of benzodiazepines may be safer alternatives for controlling the delirium and agitation because neuroleptics will worsen the hyperthermia in some cases of overdose and lead to fatality. Acute use of benzodiazepines can also help minimize the need for physical restraints. During high-dose stimulant use, often seen during binge episodes, individuals can experience stimulant- induced psychosis characterized by delusions, paranoid thinking and stereotyped compulsive behavior.
    [Show full text]
  • Hangover Syndrome: Pathogenesis and Treatment
    ISSN: 2690-263X Razvodovsky. Int Arch Subst Abuse Rehabil 2021, 3:009 DOI: 10.23937/2690-263X/1710009 Volume 3 | Issue 1 International Archives of Open Access Substance Abuse and Rehabilitation ORIGINAL RESEARCH Hangover Syndrome: Pathogenesis and Treatment Razvodovsky YE* Check for Department of Medico-Biological Problems of Alcoholism, Institute Biochemistry of Biologically Active updates Substances Academy of Science of Belarus, Russia *Corresponding author: Razvodovsky YE, Head of the Department of Medico-Biological Problems of Alcoholism, Institute of Biochemistry of Biologically Active Compounds, National Academy of Sciences of Belarus, Belarus, 230009, Grodno, 50 BLК str., Russia concentration, cognitive deficit) symptoms [5,10]. Abstract Aim: To discuss the state of art of pathogenesis and treat- A study on volunteers who injected themselves with ment of Hangover Syndrome (HS). alcohol intravenously showed that the morning after Methods: The review of the Russian and English language self-administration of alcohol 78% of the participants literature related to this problem. experienced at least one hangover symptom [6]. The Results: It was shown, that there is a significant gap in the most common symptoms of HS were: Fatigue (67%), understanding of pathogenesis of HS, which hamper the thirst (57%), and headache (32%) [6]. The symptoms elaboration of means of metabolic correction of this condi- of a HS appear 6-8 hours after the end of alcoholic ex- tion. The target of majority of currently existing means of cess and can be observed for 20 hours against the back- treatment of HS is one of the pathogenic mechanisms of ground of the absence of alcohol in the blood [10].
    [Show full text]
  • Pregabalin Matches Naltrexone in Lowering Alcohol Craving
    28 Addiction Psychiatry C LINICAL P SYCHIATRY N EWS • October 2008 Type of Drink Is More Critical Than Number BY KERRI WACHTER Amee J. Epler, a graduate student in psychological sci- tired than usual,” “headache,” “nauseous,” “very weak,” Senior Writer ences at the University of Missouri, Columbia, and her “extremely thirsty,” or “dehydrated.” colleagues. The mood states included “scared,” “upset,” “dis- B ALTIMORE — Drinking clear liquors—such as vodka The researchers studied the drinking habits of 127 tressed,” “enthusiastic,” “interested,” and “proud.” and gin—and drinking more than one type of alcoholic students at a large Midwestern university over a 14-day Almost three-quarters (73%) reported at least one beverage are both associated with an increased risk of period. The sample was predominantly white (85%), drinking episode over the 14-day study; 41% reported at having a hangover among college students, even after con- with slightly more women (61%). Smokers accounted least one hangover. Among participants who reported at trolling for the number of drinks. for 43%. least one hangover, the number of hangovers ranged Students who drank clear liquors were twice as likely The students monitored their experiences several times from one to seven (median two). Drinking episodes and to have a hangover as those who drank beer, even after a day during a 14-day period using an electronic diary. The reports of hangover were associated primarily with controlling for the number first question asked each day weekends—75% of each occurred on Fridays, Saturdays, of drinks, according to a Students who drank clear liquors were was whether the student had or Sundays.
    [Show full text]