March 18, 2020 SPECIAL .COM 2YO SALE Know What You’re Buying: The Messy World Of Compounding Pharmacies By Natalie Voss

From Dec. 28 to Dec 30, 2015, inspectors from Florida’s During week in 2016, Kentucky Horse Department of Health observed business at Ergogenic Labs Racing Commission officials received a report that a non- in Wellington, Fla., where pharmacist Scott Mangini oversaw veterinarian representing Ergogenic was on the backstretch the compounding of human and animal drugs. The inspectors at Churchill Downs, hoping to interest trainers in purchasing were not happy with what they found. a compounded ulcer medication, allegedly without requiring them to obtain a prescription. In a subsequent report dated Jan. 5, 2016, they “noted serious deficiencies of state and federal law,” including “filthy Despite the filthy conditions described in reports to the conditions in the pharmacy’s clean room,” mislabeled or Florida Department of Health after the December inspection, unidentified drugs on the shelves, and several substances Ergogenic Labs remained in operation for months. in bottles labeled “Not intended for humans or animals” and “Not for Drug, Household, or Other Uses.” The floor of In March 2020, Mangini was one of 27 people indicted by the pharmacy was so filthy that one inspector was able to the Federal Bureau of Investigation connected to an alleged write the initials “DOH” in the dust with an alcohol swab. The equine doping ring that included trainers Jason Servis and pharmacy, the inspectors wrote, was not conducting tests Jorge Navarro. for sterility or for endotoxin contamination of their products. One report from the Florida Department of Health said Horsemen may want to consider themselves their own best employees were washing their hands in a bucket in lieu of a Continued on Page 5 working sink.

Compounding pharmacies are often used by veterinarians to provide a form of medication that’s commercially unavailable by changing the route of administration (like making an oral paste get on BOARD version of a drug that’s typically injected), adding flavoring, or producing a drug during a manufacturing shortage. Many humans and animals use compounded drugs without incident, PAID BOARDING UP TO 30 DAYS on all new but some pharmacies have made headlines in recent years bookings to $15,000-or-under stallions. for recurring neglect or making drugs outside the bounds of federal law.

In February 2016, the Florida Department of Health filed a report calling for an emergency restriction on Mangini’s license to operate the pharmacy. Their December inspection convinced them that Mangini had failed in his capacity as the pharmacy’s Prescription Department Manager. Not only had he overseen the shoddy conditions, but he was in charge while the pharmacy compounded an illegal omeprazole drug called UlcerRX using ingredients labeled “not for drug, household or other uses.” The department also alleged he failed to keep a proper audit trail of drugs like furosemide, sildenafil, Procrit, Aranesp, among other substances.

Weeks later, Mangini, a longtime owner in both the Standardbred and racing worlds, voluntarily surrendered Ergogenic’s Special P/E license, which allowed sterile compounding at the facility, to avoid further sanctions from the Florida Board of Pharmacy. Among other items in DES | 859.509.2106 MARK | 859.421.0151 BRIAN | 859.519.6477 the agreement Mangini signed was a promise that Ergogenic would never reapply for a Special P/E license in Florida, and that Ergogenic “agrees to voluntarily cease operating as a pharmacy immediately upon executing this Voluntary THE BREEDERS' FARM Relinquishment.” Page 2

ASK YOUR VETERINARIAN PRESENTED BY Switching Vaccine Brands On New Horses By Dr. Kevin Hyde

Veterinarians at Rood and early enough to give the horse’s body adequate time Riddle Equine Hospital answer to build up protective immunity prior to the sale. If your questions about sales and buying a horse from a sale, we need to realize that healthcare of Thoroughbred auction their protective levels may have been lower during that yearlings, weanlings, 2-year-olds and “stressful” event and treat the new horse accordingly. breeding stock. This includes effective biosecurity measures and herd health practices to protect all of the horses on the farm. Email us at info@paulickreport. com if you have a question for a Remember, no vaccine is perfect and can’t be veterinarian. guaranteed to prevent 100 percent of infections. But Dr. Hyde by following the manufacturer’s guidelines, under the direction of our veterinarians, we will have the best QUESTION: Since some veterinarians and farms use chance for success. different types of vaccines, is it a problem to buy an individual and start it on another type? Dr. Hyde graduated from the Washington State University School of Veterinary Medicine in 2005. He DR. KEVIN HYDE: The short answer to this question is completed an internship at Rood and Riddle Equine no. In this day and age, vaccines from all of the major Hospital in 2006 and then became an associate with the pharmaceutical companies have a significant amount of practice for five years. Dr. Hyde became a shareholder at research behind them and do a good job of protecting Rood and Riddle at the beginning of 2019. PRS our horses from the diseases they were created against.

Is there one vaccine that is slightly more effective than another? Maybe. But if you feel comfortable with one Want Strong, brand or line of vaccine than another and it has done a good job on your farm, there is no reason you can’t switch Resilient Bones? a new horse over to the brand you are comfortable with. TM

In an ideal world, we would always get the complete Get BoneWise vaccine history from the previous owner and could just continue giving the same vaccine without missing a • Research-proven. beat. Unfortunately, more times than not, we don’t get a complete history and there can be questions about how • Supports optimal well the horse has actually been vaccinated. In these bone strength cases, we should probably treat the horse as if it has never been vaccinated. We should begin vaccinating with and formation. the initial series recommended by the manufacturer to ensure that an adequate immune response is initiated to protect our new horse. After that the new horse can be placed on the routine vaccine schedule you have put together with your veterinarian for your particular farm.

Even if we know the vaccine history and still decide to switch to a vaccine we are more comfortable with, we should use the recommended initial series for that vaccine. This is to ensure that the levels of protective immunity are reached for that specific vaccine. Because each vaccine works slightly differently to create an immune response, the full recommended series may be Developed by: needed to get to the levels of immunity to be protective.

Sales and long-distance transport can be very stressful for a horse. Stressful events such as this can reduce a Sold through veterinarians only. KPPvet.com, 859-873-2974 horse’s immune response. It’s important to vaccinate Paulick 2020 CLASSIC STALLIONS MAX PLAYER PRODUCING CLASSIC CONTENDERS FROM THEIR FIRST CROP OF RUNNERS HONOR CODE A.P. Indy – Serena’s Cat, by Storm Cat MAX PLAYER (G3) and HONOR A. P. (G2P) BASIN LIAM’S MAP Unbridled’s Song – Miss Macy Sue, by Trippi

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LESSON HORSES PRESENTED BY Catherine Parke Of Valkyre Stud On Heartlight No. One By Joe Nevills

sounds corny, but she’d scream and holler, and I’d rush and get the banamine. I’d rush and give that to her, and then walk her. She taught me more about horses than anybody.

I had a radio sensor from Australia on her, and when she’d lay down for five seconds, I had a beeper and it would beep me, so if it was 3 a.m. and she laid down for that long, it would send this radio signal off and I’d go rushing to the barn. I was 27 years old and I didn’t have a year-round nightwatchman. I couldn’t afford one, so I was the year- round nightwatchman, but it was worth it.

She was a brilliant, brilliant racehorse and a beautiful mare. He pelvis was fractured, so her hind gut was compromised, circulatory-wise, so she colicked a lot. She wouldn’t have lived two years, but I lived with her literally for a very long LIBRARY THOROUGHBRED TIMES COLLECTION time, and I don’t regret it at all. I was with her 24/7 pretty Heartlight No. One much her entire life, and it made me realize that I really love horses and wanted to do this. It never occurred to me I QUESTION: Which horse has taught you the most couldn’t do it. PRS about life?

CATHERINE PARKE: Heartlight No. One, Burt HEARTLIGHT NO. ONE 1980 (Rock Talk x Icantell, by Tell) Bacharach’s champion 3-year-old filly. She had a fractured

pelvis when she came from the track and she colicked A homebred for musician Burt Bacharach, Heartlight No. once a week for her entire life. I literally lived with her for One raced for one season, but she made it count, winning 10 years. She had three surgeries, lots of banamine, and five of seven starts to clinch champion 3-year-old filly honors at that point, I realized how much I really loved horses. in 1983. She notched wins in the G1 Hollywood Oaks and G2 Del Mar Oaks, and beat older competition in the G1 She lived to be 18, and she was a wonderful horse, but Ruffian Handicap before her career ended due to injury. she would tell me when she was going to colic. I know that Page 5

Continued from Page 1 protection against using dangerous compounds on horses. A study from the Minnesota Racing Commission found Fortunately, experts say there are a few things consumers can compounded triamcinolone acetate (used for osteoarthritis) do to determine whether the pharmacy they’re buying from is that was labeled at a strength of 6 mg/ml but contained only operating according to acceptable standards. .00828 mg/ml. A study from the University of California-Davis compared compounded formulations of the bronchodilator Many horsemen purchase drugs from compounders in an clenbuterol and found one as high as ten times its labeled effort to save money, but Dr. Dionne Benson, former executive concentration, which could be enough to kill a horse. director of the Racing Medication and Testing Consortium and now chief veterinary officer at The Stronach Group, said A close look at the label of a compounded product could price should be a big “tell”—particularly if the drug you’re buying also tell a lay person whether the drug has been put claims to combine two commonly-used remedies for the same together thoughtfully. Authorized medication (including problem, like omeprazole and ranitidine, which both treat compounds) will have a national identification number gastric ulcers. (some drugs have NADA numbers, others ADA, NBC, or ANADA) that should correspond to the ingredients “True compounded medications [that are combinations] inside the drug’s packaging. The FDA also maintains an should cost more than either medication [on its own] because online “green book” that contains authorized producers you should be using two FDA-approved medications,” said of prescription drugs such as phenylbutazone (including Benson. “It’s not so concerning with omeprazole and ranitidine, generics). but with some drugs we don’t know how they play together. They could turn into battery acid, they could make one much “When you don’t see those, that’s when you should get a little stronger, they could make one much weaker, they could cancel concerned,” said Benson. each other out and you could be doing nothing.” Insiders suggest that seals of approval from many private The reason FDA-approved versions of drugs are more organizations professing to certify a pharmacy’s quality are expensive isn’t price gouging; it’s because the testing process less meaningful than they were a few years ago. The possible for a new animal drug takes years and tens of thousands exception to this is Verified Internet Pharmacy Practice Sites of dollars. It also requires regular testing for the sterility of (VIPPS), which is an arm of the National Association of Boards the ingredients and the consistency of the resulting product. of Pharmacy. PRS Without that, Benson said, trainers and horsemen are running A version of this feature was originally published in 2016. the risk of incurring a drug overage or even worse, poisoning Read the full extended version on PaulickReport.com their horse with an incorrectly-formulated compound. About CLOVIS CRANE BARN FIRE REBUILD FUND For advertising inquiries please call Emily at 859.913.9633 Ray Paulick - Publisher [email protected] Emily Alberti - Director of Advertising [email protected] Scott Jagow - Editor-in-Chief [email protected] Joe Nevills - Bloodstock Editor [email protected] Natalie Voss - Features Editor [email protected] Chelsea Hackbarth - Racing News Editor [email protected] Amy McLean - Print and Advertising Production Frank Mitchell - Contributing Writer COPYRIGHT © 2020, BLENHEIM PUBLISHING LLC Pennsylvania horseman Clovis Crane suffered a devastating barn fire on March 7, in which he lost 15 horses pointed toward Get The Week’s Top this season’s 2-year-old sales. Horse Health News Donate to help rebuild his operation. direct to your inbox each Tuesday

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Second-Crop Sire Roundup Second Crop Of 2-Year-Olds At OBS March By Joe Nevills

Stallions whose second crops of 2-year-olds are represented in the Ocala Breeders’ Sales Co. March Sale of 2-Year-Olds In Training, including the number of horses cataloged and the farm where the stallion is currently advertised.

Admiral Kitten – (3) Southford Stud, South Africa American Pharoah – (6) Ashford Stud, Ky. Bahamian Squall – (1) Double Diamond Farm, Fla. Bayern – (3) Hill ‘n’ Dale Farms, Ky. Carpe Diem – (8) WinStar Farm, Ky. Chitu – (6) Bridlewood Farm, Fla. Commissioner – (4) WinStar Farm, Ky. Competitive Edge – (6) Ashford Stud, Ky. Constitution – (6) WinStar Farm Danza – (1) Fair Winds Farm, Ohio Daredevil – (3) Turkey Fast Anna – (2) Three Chimneys Farm, Ky. Frac Daddy – (1) Park Stud, Ont. Honor Code – (5) Lane’s End, Ky. Jack Milton – (3) Crestwood Farm, Ky. Karakontie – (1) Gainesway, Ky. Khozan – (2) Journeyman Stallions, Fla. Lea – (2) Claiborne Farm, Ky. Liam’s Map – (11) Lane’s End, Ky. Micromanage – (1) Rockridge Stud, N.Y. Palace – (7) Farm, Ky. Palace Malice – (4) Three Chimneys Farm, Ky. Race Day – (1) Spendthrift Farm, Ky. Summer Front – (4) Airdrie Stud, Ky. Tapiture – (4) Darby Dan Farm, Ky. Tonalist – (3) Lane’s End, Ky. Wicked Strong – (9) Spendthrift Farm, Ky.