Anti-ITGB7 (Aa 736-765) Polyclonal Antibody (DPABH-21895) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-ITGB7 (aa 736-765) polyclonal antibody (DPABH-21895) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Immunogen Synthetic peptide conjugated to KLH, corresponding to a region withn C terminal amino acids 736-765 of Human Integrin beta 7 (NP_000880.1).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 400 μl

Buffer Constituent: 99% PBS

Preservative 0.09% Sodium Azide

Storage Store at 4°C (up to 6 months). For long term storage store at -20°C

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name ITGB7 integrin, beta 8 [ Homo sapiens ]

Official Symbol ITGB7

Synonyms ITGB7; integrin, beta 7; integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit;

Entrez Gene ID 3695

Protein Refseq NP_000880.1

UniProt ID P26010

Pathway Adaptive Immune System; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cell adhesion molecules (CAMs); Dilated cardiomyopathy

Function metal ion binding; protein binding; virus receptor activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]